50 1 Food and Drug Administration, FDA 1999 O T C F i n a l U S P1 999 F D A M o n o g r a p h The EU Cosmetic Directive 3, 4 Digalloyl triole

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1 49 ISSN PIC/S Kadariah Mohamed Ali D r. Lai Pharmaceutical Inspection Convention / Pharmaceutical Inspection Cooperation Scheme, PIC-PIC/S G M P G M P G M P G M P 26 G M P 86 P I C / S R o b e r Tr i b e Daniel Brunner J a c q u e s M o r e n a s G M P G M P G M P P I C / S M r. Robert Tr i b e M r. Daniel Brunner Ms. France Dansereau M r. Jacques Morenas M s. Weng Fai Ms. Bronwyn Phillips

2 50 1 Food and Drug Administration, FDA 1999 O T C F i n a l U S P1 999 F D A M o n o g r a p h The EU Cosmetic Directive 3, 4 Digalloyl trioleate E t h y l dihydroxypropyl PA B A G l y c e r y l O c t i n o x a t e PA B A Pentyl dimethyl PABA R e d O c t i s a l a t e p e t r o l a t u m D E A H a r m o n i z a t i o n m e t h o x y c i n n a m a t e Lawsone with DHA CTFA Ensulizole Phenylbenzimidazole sulfonic acid Meradimate Menthyl anthranilate Octinoxate Octyl methoxycinnamate Octisalate Octyl salicylate CTFA Cosmetic, Toiletry and Fragrance Association C o s m e t i c, Toiletry and Fragrance Association C T FA International Cosmetic esters F D A S P F 2 Ingredient Dictionary S P F S P F 30 8 O c t y l 30 SPF 30 plus SPF e t h y l h e x y l 30 + S P F

3 51 2 F D A Final Sunscreen Monograph, U VA U V B F D A SPF U V B S P F 30 U VA U VA 2 2 SPF INCI (%) Aminobenzoic acid PABA 15 Avobenzone Butyl methoxydibenzoyl methane 3 Cinoxate 3 Reserved Dioxybenzone Benzophenone-8 3 Homosalate Homosalate 15 Reserved Meradimate Menthyl anthranilate 5 Octocrylene Octocrylene 10 Octinoxate Ethylhexyl methoxycinnamate 7.5 Octisalate Ethylhexyl salicylate 5 Oxybenzone Benzophenone-3 6 Padimate O Ethylhexyl dimethyl PABA 8 Ensilizole Phenylbenzimidazole sulfonic acid 4 Sulisobenzone Benzophenone-4 10 Titanium dioxide 25 Trolamine salicylate TEA-salicyate 12 Zinc oxide 25 INCI International Nomenclature Cosmetic Ingredient S P F SPF %, Titanium dioxide Zinc oxide Japan Cosmetic Industry Association, JCIA S P F

4 52 INCI CLS* (%) 2,4-Dihdroxybenzophenone Benzophenone ',2',4',4'- Benzophenone Tetrahydroxybenzophenone Oxybenzone Benzophenone Hydroxy-4- Benzophenone methoxybenzophenone-5- sulfonic acid Sodium Benzophenone hydroxymethoxybenzophenone sulfonate Dihydroxy dimethoxy Benzophenone benzophenone Disodium 2,2(-dihydroxy-4,4'- Benzophenone dimethoxy-5,5'- disulfobenzophenone 4-tert-Butyl-4'- Butyl methoxydibenzoylmethane methoxydibenzoylmethane Cinoxate Cinoxate Dipropylene glycol salicylate Dipropylene glycol salicylate Glyceryl octanoate di-p- Glyceryl ethylhexanoate methoxycinnamate dimethoxycinnamate Glyceryl p-aminobenzoate Glyceryl PABA Homomenthyl salicylate Homosalate Isopropyl p-methoxycinnamate Isopropyl methoxycinnamate diisopropylcinnamate esters mixture 2-Ethylhexyl p-dimethylamino Ethylhexyl dimethyl PABA benzoate 2-Ethylhexyl 4- Ethylhexyl methoxycinnamate methoxycinnamate Octyl salicylate Ethylhexyl salicylate p-aminobenzoic acid PABA ,5-Diisopropyl methyl Diisopropyl methyl cinnamate cinnamate 2-Ethylhexyl None dimethoxybenzylidene dioxoimidazoline propionate Ethyl p-aminobenzoate Ethyl PABA ,4,6-Tris[4-(2-ethylhexyl Ethylhexyl triazone oxycarbonyl)anilino]-1,3,5- triazine Micro particle titanium dioxide Titanium dioxide No limit Titanium dioxide Titanium dioxide No limit Zinc oxide Zinc oxide No limit *CLS Comprehesive Licensing Standards of Cosmetics

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6 54 SNBTS G M P W H O N AT N AT

7 55 SYMPOSIUM ANNOUNCEMENT 2002 National Laboratories of Foods and Drugs Conference Quality Control and Analytical Methods of Herbal Medicine Conference Date June27~28, Conference Venue: Convention Hall, The Howard International House 30, Sec. 3, Hsih-Sheng South Road, Taipei, Taiwan. Tel: Fax: Host Organizer National Laboratories of Foods and Drugs, DOH, Taiwan Co-Organizer Bureau of Pharmaceutical Affair, DOH, Taiwan Committee on Chinese Medicine and Pharmacy, DOH, Taiwan Foundation of Center for Drug Evaluation Foundation of Pharmaceutical Industry Technology and Development Center Foundation of Medical Professionals Alliance in Ta i w a n AOAC INTERNATIONAL Taiwan Section Under the Auspices of Department of Health DOH, Executive Yuan, Taiwan Conference Topics Authenticity of Raw Material Analytical Method Validation Novel Approach of Analysis in Herbal Medicine Conference Outline June 27 Morning Overview of Quality Control and Prospective Management of Herbal Medicine Chun-Heng Liao, Director General, National Laboratories of Foods and Drugs NLFD, Taiwan.

8 56 I-Hsin Lin, M.D., Ph.D., Chairman, Committee on Chinese Medicine and Pharmacy, Taiwan. 2.Approaches to the Standardization of Herbal Medicines and Its Prospects for New Drug Discovery in the 21st Century 21 Keynote Speech Dr. Kuo-Hsiung Lee, Prof., Univ. of North Carolina, USA June 27 Afternoon Botanical Quality Attributes: From Plant Materials to Finished Products : Agnes NguyenPho, Ph.D., Division of Product Quality Research, Center for Drug Evaluation and Research CDER, FDA, USA. 2.Quality Requirements for Modern Herbal Medicine Products H M P According to European Pharmacopoeia Gerhard Franz, Ph.D., Prof., School of Pharmacy, University of Regensburg, Germany. 3. Identification and Quality S p e c i f i c a t i o n Control of Raw Material of Tr a d i t i o n a l Chinese Medicine TCM Hsien-Chang Chang, Ph. D., Pharmacognosy Division, NLFD 4.Quality Control of Preparation of TCM Cheng-Yu Huang, Section Chief, Pharmacognosy Division, NLFD June 28 Morning Validating Analytical Methods in Difficult Matrices Joseph M. Betz, Ph.D., Director, Dietary Supplements Methods and Reference Materials Program, Office of Dietary Supplements, National Institutes of Health NIH, USA. 2. Isolation and Purification of Marker Constituents from TCM Jer-Huei Lin, Ph. D., Director, Pharmacognosy Division, NLFD.

9 57 3.A Feasible Strategy for Applying Chromatography Fingerprint to Assess Quality of Chinese Herbal Medicine Pei-shan Xie, Prof., Guangzhou Institute for Drug Control, GuangDong, China; 4.Analysis of Synthetic Therapeutic Substances Adulterated in TCM Mei-Jyh Lin, Senior Scientist, Pharmacognosy Division, NLFD. June 28 Afternoon Application of Monoclonal Antibodies Against Natural Products in the Field of Crude Drugs and Foods Yu k i h i ro Shoyama, Ph.D., Prof., Graduate School of Pharmaceutical Sciences, Kyushu University, Japan. 2.The Turnover Rate of Marker Constituents in TCM Kuo-Ching Wen, Ph. D., Director, Drug Chemistry Division, NLFD. 3.LC/MS/MS in the Analysis of Herbal Medicines Emil T. Lin, Ph.D., Prof., School of Pharmacy, University of California, San Francisco, USA. 4.Innovative Approaches to the Characterization of Plant Medicines Peter Hylands, Ph.D., Chief Scientific Officer, Oxford Natural Products, UK 5.Panel discussion Conference Language: English and Chinese, Simultaneous Translation Available Lunch: Buffet Accommodation: The Howard International House 180

10 58 Target Audience Who should Attend - Pharmaceutical and botanical industry -Industry organization -Regulatory affair - Regulatory agency - Academia It's Easy to Enroll Register Now -QC and R&D chemist and manager Conference Enrollment Form P h o n e (886-2) Conference information Fax (886-2) Please enroll me in the conference pjquan@nlfd.gov.tw Before the date of May 31, Mail Office of AOAC INTERNATIONAL Taiwan Enroll fee Industry $NT 2000 Section KuenYang St. Nankang, Ta i p e i, Academia & Government $NT 1200 Taiwan After the date of June 1, Enroll fee Industry $NT 2500 Academia & Government $NT 1500 For more information Attendee Information C a ll Name Title F ax Conference Director Director, Jer-Huei Lin, Ph.D. Company or Institution Address Phone Fax General Information: Fee Covers: Conference Materials and Break refreshments, and Lunch. Cancellation: If you cannot attend, please notify us at least 7 days before the day of conference and we will refund your conference fee. Cancellation received later than SEVEN days before the conference date is subject to a $NT 500 late fee. All cancellations made on or after the conference date are subject to the full conference fee.

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二零零三年二月十日會議

二零零三年二月十日會議 CB(1) 844/02-03(05) (a) (b) 2. 3. 4. (National Nanotechnology Initiative) 5 6.04 7.1 20 (2.4 ) - 2-5. ( ) 1.07 6. 7. 8. 9. 7 4,150 10. (TiO2) - 3-11. ( ) 12. ( ) A 13. 14. (a) ( ) (b) ( ) 15. (a) (b) (c)