Influenza-associated paediatric respiratory hospitalizations in China, : a systematic analysis Supplementary files Mei Shang, Kathryn E. Lafo

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1 Influenza-associated paediatric respiratory hospitalizations in China, : a systematic analysis Supplementary files Mei Shang, Kathryn E. Lafond, Jeffrey McFarland, Suizan Zhou, John Klena and Marc-Alain Widdowson SUPPLEMENTARY TABLE 1. LITERATURE SEARCH METHODOLOGY AND RESULTS, BY DATABASE 2 SUPPLEMENTARY TABLE 2. SUMMARY OF PUBLISHED ARTICLES INCLUDED IN THE ANALYSES 5

2 Supplementary Table 1. Literature search methodology and results, by database Database Search terminology Results Embase 1. exp influenza/ OR exp influenza virus/ OR exp influenza A/ OR exp influenza B/ OR exp influenza C/ OR exp influenza virus A / OR exp influenza virus B / OR exp influenza virus C / OR exp seasonal influenza/ OR influenza.mp OR viral etiology.mp 2. exp respiratory tract infection/ OR exp acute respiratory tract disease/ 3. exp pneumonia/ OR exp virus pneumonia/ 4. exp bronchiolitis/ OR exp viral bronchiolitis/ OR exp bronchitis/ 5. exp flu like syndrome/ OR influenza-like illness.mp 6. ILI.mp OR SARI.mp OR ARI.mp OR ALRI.mp OR LRTI.mp OR CAP.mp 7. 1 AND (2 OR 3 OR 4 OR 5 OR 6) 8. Limit 7 to (human and yr= 1996-Current ) Web of Science Global Health (TS= (Influenza) OR TS=(viral etiology)) AND (TS=(Acute Respiratory Infections) OR TS=(respiratory diseases) OR TS=(respiratory illnesses) OR TS=(Pneumonia) OR TS=(influenza-like illness) OR TS=(lower respiratory tract infections) OR TS=(bronchiolitis) OR TS=(bronchitis)) Time span= exp influenza/ OR exp influenza viruses/ OR exp Influenzavirus A/ OR exp Influenzavirus B/ OR exp Influenzavirus C/ OR influenza.mp OR viral etiology.mp 2. exp respiratory diseases/ or exp lower respiratory tract infections 3. exp pneumonia/ 4. exp bronchiolitis/ OR exp bronchitis/ 5. influenza-like illness.mp OR ILI.mp OR SARI.mp OR ARI.mp OR ALRI.mp OR LRTI.mp OR CAP.mp 6. 1 AND (2 OR 3 OR 4 OR 5) 7. Limit to yr= 1996-Current

3 Database Search terminology Results PubMed 1. influenza, human[sh] OR influenza A virus[majr] OR influenza B 3596 virus[majr] OR influenza C virus[majr] OR influenza[all] OR viral etiology[all] 2. respiratory tract infections[sh] OR respiratory tract diseases[sh] 3. pneumonia[majr] OR pneumonia, viral[sh] 4. bronchiolitis[sh] OR bronchiolitis, viral[sh] OR bronchopneumonia[sh] 5. influenza-like illness[all] 6. acute respiratory[all] OR acute lower respiratory[all] OR lower respiratory[all] 7. ILI[all] OR SARI[all] OR ALRI[all] OR LRTI[all] OR CAP[all] 8. 1 AND (2 OR 3 OR 4 OR 5 OR 6 OR 7) 9. Limit 8 to ("1996/01/01"[PDAT] : "3000/12/31"[PDAT]) AND "humans"[mesh Terms]) CINAHL LILACS WHOLIS IndMed (TX influenza OR TX influenza virus OR TX viral etiology) AND (TX respiratory infections OR TX pneumonia OR TX influenza-like illness OR TX acute respiratory OR TX lower respiratory OR TX "ILI" OR TX "SARI" OR TX "ALRI" OR TX "ARI" OR TX "LRTI" OR TX "CAP") Limiters: ; human (Influenza) AND (respiratory disease OR respiratory infection OR pneumonia) (influenza OR influenza virus OR viral etiology) AND (respiratory infection OR respiratory disease OR respiratory illness OR acute respiratory OR lower respiratory OR pneumonia OR bronchiolitis OR bronchitis OR SARI OR ILI OR ARI OR ALRI OR LRTI OR CAP) Publication year: (Influenza) AND (respiratory disease OR respiratory infection OR pneumonia)

4 Database Search terminology Results CNKI 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 呼吸系统感染 (respiratory infection) 甲流 or 流感 or 病毒病原学 (influenza group keywords )And 呼吸系统疾病 ( another name of respiratory infection) 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 肺炎 or 下支气管炎 (pneumonia or bronchiolitis ) 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 肺炎 or 上支气管炎 (pneumonia or bronchitis ) 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 流感病样病例 (ILI Chinesename) or ILI 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 急性呼吸道感染 ( sari chinese name) or SARI 甲流 or 流感 or 病毒病原学 (influenza group keywords) And ARI 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 急性下呼吸道感染 (LRTI Chinese name) or LRTI 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 急性上呼吸道感染 (LRTI Chinese name) or LRTI 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 非典型肺炎 (SARS Chinese name) or SARS 甲流 or 流感 or 病毒病原学 (influenza group keywords) And 社区活动感染 (CAP Chinese name) or CAP 883

5 Supplementary Table 2. Summary of published articles included in the analyses First Author City/Region Province Years Age Range Case Definition Diagnostic Test % Influenza Positive, age <18 % Influenza Positive, age <2 % Influenza Positive, age <5 Nong GN Nanning Guangxi Sep 1994-Sep ARI APAAP (33) Zhang J Suzhou Jiangsu Oct 1990-Oct month-7 ALRI/LRTI APAAP (34) Zhu Y Nantong Jiangsu ALRI/LRTI APAAP (35) Liu C Beijing Beijing Mar 1995-Jun days-28 days Pneumonia Immunoassay (36) Luo S Hangzhou Zhejiang Jan 1999-Dec months-14 Other Multiple tests including (37) Lu M Shanghai Shanghai Jun 1995-Aug month-12 Pneumonia APAAP (38) Ding Y Shanghai Shanghai Sep 1993-Oct ARI APAAP (39) Tsai SouthernTaiwan Taiwan Jan 1997-Dec ARI Others (40) Wang Y Yinchuan Ningxia Aug 1999-Jul ARI ELISA (41) Liu GR Beijing Beijing Mar 1997-Mar 4-5.3months ALRI/LRTI Immunoassay (42) 1999 Zhang YM Xian Shaanxi Jan 1994-Dec days-11 Pneumonia APAAP (43) Zhu RN Beijing Beijing Nov 2000-Aug ARI Multiple tests excluding (44) Chen HH Guangzhou Guangdong Mar 2003-May 0-18 ALRI/LRTI (45) 2004 Che DD Shanghai Shanghai Jan 2000-Dec ALRI/LRTI APAAP (46) Wang XW Zhengzhou Henan Mar 2002-Mar days-14 ALRI/LRTI ELISA (47) Liu L Changchun Jilin Oct 2000-Apr months-16 ARI ELISA (48) Ding Z Shanghai Shanghai Jan 2000-Dec month-12 ARI Immunoassay (49) Sun LX Tianjin Tianjin Jan 2002-Mar Other Immunoassay (50) Ye LF Hangzhou Zhejiang Jan 2000-Feb day-3 ALRI/LRTI Immunoassay (51) Cao L Beijing Beijing Feb 2001-Mar month-5 ALRI/LRTI Multiple tests excluding (52) Reference

6 Yan M Xining Qinghai Oct 2003-Oct month-8 ARI ELISA (53) Lu M Shanghai Shanghai Oct 2002-Apr 2004 <1 month-16 ALRI/LRTI Immunoassay (54) Lin Taipei Taiwan Aug 2001-Jul Pneumonia Multiple tests including (55) Liu Xian Shaanxi Jul 2003-Jun days-10 Pneumonia ELISA (56) Wang LJ Chongqing Chongqing Apr 2003-Mar ARI Immunoassay (57) Xiang QW Wenzhou Zhejiang Jan 2003-Jan month-13 ALRI/LRTI Immunoassay (58) Chen XF Wenzhou Zhejiang Jan 2003-Apr month-3 ALRI/LRTI Immunoassay (59) Luo XJ Chongqing Chongqing Apr 2003-Dec ARI Immunoassay (60) Li J Shanghai Shanghai Jan 2005-Dec month-8 ALRI/LRTI Immunoassay (61) Cao HX Qinghai Qinghai Jan 2003-Dec month-15 Pneumonia Others (62) Yuan Y Beijing Beijing Sep 2003-Jul month-14 ARI Immunoassay (63) Li HZ Zhaoqing Guangdong Jan 2003-Jun month-12 ALRI/LRTI Others (64) Huang HY Guangzhou Guangdong Sep 2000-May ARI ELISA (65) Luo R Chongqing Chongqing Mar 2004-Mar month-14 ARI Immunoassay (66) Deng JK ShenZhen Guangdong Dec 2003-Nov ALRI/LRTI ELISA (67) Liu YR Xian Shaanxi Nov 2003-Oct days-28 days Pneumonia ELISA (68) Bei GP ZhouShan Zhejiang Apr 2004-Apr ARI Immunoassay (69) Zhang YL Wenzhou Zhejiang Jan 2003-Jun days-14 ARI Immunoassay (70) Cheuk HongKong Hong Kong Aug 2001-Jul ARI Immunoassay (71) Lin JB Wenzhou Zhejiang Oct 2005-Feb month-3 Pneumonia Immunoassay (72) Qin M Nanjing Jiangsu Apr 2006-Mar month-14 Pneumonia Immunoassay (73) Wang Beijing Beijing Nov 2000-Jun ARI Multiple tests excluding (74) Fan M Kunming Yunnan Oct 2005-Oct ALRI/LRTI Immunoassay (75)

7 Qian J Wuxi Zhejiang Dec 2006-Nov days-9 ARI Immunoassay (76) Yang K GuiLin Guangxi Sep 2005-Sep days- 12 ARI Multiple tests excluding (77) Liao SF Jianyang Sichuan Jan 2006-Dec Pneumonia ELISA (78) Tang Hangzhou Zhejiang Jan 2001-Dec ALRI/LRTI Immunoassay (79) Ou Shantou,jieyang Guangdong Jan 2007-Dec month-5 ALRI/LRTI (80) Liu Beijing Beijing Mar 2007-Feb month-15 ALRI/LRTI (81) Peng Wuhan Hubei May 2008-Apr 0-14 ARI Immunoassay (82) 2009 Zhang Harbin Heilongjiang Jan 2008-Dec ALRI/LRTI Immunoassay (83) Dalian Liaoning May 2007-May 0-14 Pneumonia ELISA (84) Chen HX 2008 Chiu Hong Kong Hong Kong Oct 2003-Sep ARI Multiple tests excluding (85) Yang WM WeiFang Shandong Nov 2007-Nov 2month-6 Other Immunoassay (86) 2008 Tsung Hong Kong Hong Kong Nov 2005-Apr Other Multiple tests including (87) Chen Q Nanjing Jiangsu Sep 2008-Aug h-14 ARI Immunoassay (88) Li H Shuangyashan Heilongjiang Jan 2007-Jun d-14 ARI Immunoassay (89) Hu Jiaxing Zhejiang Feb 2007-Dec days-6 ARI Immunoassay (90) Ren FM ShuangYashan Heilongjiang Jan 2003-Jun days-14 ARI Immunoassay (91) Chang J Wenzhou Zhejiang Jan 2007-Dec days-13 ARI Immunoassay (92) Tan LG Huizhou Guangdong Jan 2008-Dec ±5.5d Pneumonia Immunoassay (93) Liu JP Taizhou Zhejiang Mar 2008-Jun y ARI ELISA (94) Yu Chongqing Chongqing Dec 2006-Mar 3 days-44 Pneumonia (95) 2008 month Chen XQ Nanjing Jiangsu May 2009-Apr 1 month-14 ARI (96) 2010 Gong XY Yiwu Zhejiang Apr 2008-Mar days-14 ALRI/LRTI ELISA (97) Xu Z Suzhou Jiangsu Jun 2006-Jun month- 15 Other Immunoassay (98) year Mao XJ Guangzhou Guangdong Jan 2005-Dec Pneumonia Others (99)

8 Ji Suzhou Jiangsu Jan 2006-Dec month-10 ARI Immunoassay (100) LI Shifen Chongqing Chongqing Jan 2005-Dec Pneumonia ELISA (101) Zhang Lanzhou Gansu Oct 2004-Oct month- 14 Pneumonia Immunoassay (102) Zhang HJ Changsha Hunan Nov 2009-Dec SARI (103) Jin Lanzhou Gansu Dec 2006-Nov ALRI/LRTI (104) Xu Y ZhuHai Guangdong Jun 2009-May 2011 all age Pneumonia (105) Jiang HY Beijing Beijing May 2010-May 2-14month Other (106) 2011 Xiao Changsha Hunan Sep 2007-Aug days-14 ALRI/LRTI (107) Xue YM Lanzhou Gansu Apr 2010-Mar month-14 ARI ELISA (108) Zhang ZT Zibo Shandong Sep 2008-Dec ARI ELISA (109) Liu XG Xian Shaanxi Jan 2010-Dec month-14 ALRI/LRTI (110) Li CZ Wuhan Hubei Sep 2010-Sep ARI Immunoassay (111)

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