1932 19 tionoftheoralcavitytissue. 犓犲狔狑狅狉犱狊 :OpticalCoherenceTomography (OCT);spectral domain;parotidgland;histopathology 1 (Optical Coherence Tomography OCT) [1],,, [2], 20 90,OCT, D.Huang J.G.Fujimoto [1],, [3 9], OCT,,,,, X, ( ) OCT,,, OCT, (SpectralMain OCT), OCT 2 OCT,,,, OCT OCT,, OCT,,,,, OCT OCT OCT,, OCT,, OCT Fercher, [10] OCT 2 2,,, 犈 Rexp(i2 犽狉 )( 犈 R, 犽 =2 /λ,2 狉 );,, 犪 ( 狕 )exp[i2 犽 ( 狉 + 狀狕 )]d 狕, 犪 - ( 狕 ) 狕, 狀
8, : OCT 1933,2( 狉 + 狀狕 ) 狕,, 犐 ( 犽 ) : 犐 ( 犽 )= 犛 ( 犽 ) 狘犈 Rexp(i2 犽狉 )+ 犪 ( 狕 )exp[i2 犽 ( 狉 + 狀狕 )]d 2 狕狘, (1) - 犛 ( 犽 ), CCD λ, 犽,,,, CCD 犐 ( 犽 ),,,,, OCT, 1,,, CCD, CCD,, ;,, Fianium, 450 1800nm,, λ0 850 nm, λ 40nm 犾, : 狕 = 2ln2 λ 2 0 λ, ( 2) 7.3 m, 1 OCT Fig.1SchematicofSD OCTsystem : 狓 = 4λ0 犳, (3) 犱 犳, 犱, 9.5 m, OCT 犣 max δλ, : 犣 max= 1 λ 2 0 4 狀 δλ. (4) ( 犳 =150 mm,thorlabs), (1 200 line/mm, Thorlabs), ( 犳 =300 mm,thorlabs) CCD(e2v AViVA SM2 CL,4096 1, 10 m), 2048 0.058nm, 3.14 mm [11], 3,,,, 5 7cm,, 2 3 mm,,
1934 19 2 15 20mm, 10%,,,,Leica2255 5 m, HE( ),OlympusBX51,, OCT (c) (d) (c)normalparotidglands (d)normalparotidglands 3 OCT Fig.3 Pathologicalsectionsoftheparotidglandsand correspondingimagesofoctsystem 3(a) OCT ; 3(b),(c) (d) OCT 9.5 m, 2 Fig.2 Parotidglandsusedinexperiment 3 (a),(b),(c) (d) OCT,, 1mm;, 1 mm 3 800pixel 300pixel, 1mm 2.0mm,, ; OCT,, OCT, 4 OCT OCT, 7.3 m, 9.5 m, 3.14 mm, (a) (a)fracturedparotidglands (b) (b)normalparotidglands,,oct, OCT, OCT
8, : OCT 1935 : 1 HUANHG D.Opticalcoherencetomography J. 犛犮犻犲狀犮犲 1991 2545035 1178 1181. 2 FERCHER AF DREXLER W HITZENBERGER C K 犲狋犪犾..Opticalcoherencetomography princi plesandapplications J. 犚犲狆狅狉狋狊狅狀犘狉狅犵狉犲狊犻狀 犘犺狔狊犻犮狊 200366239 303. 3 COLSTON B W EVERETT MJ SATHYAM U S 犲狋犪犾..Imagingoftheoralcavityusingoptical coherence tomography J. 犕狅狀狅犵狉犗狉犪犾犛犮犻 2000 1732 55. 4 BAUMGARTNER A DICHTL S HITZEN BERGERCK 犲狋犪犾..Polarization sensitiveoptical coherencetomography of dentalstructures J. 犆犪狉犻犲狊犚犲狊 2000 3459 69. 5 AMAECHIB HIGHAM S M PODOLEANU A G 犲狋犪犾..Useofopticalcoherencetomographyfor assessmentofdentalcaries quantitativeprocedure J. 犑犗狉犪犾犚犲犺犪犫犻犾 2001 281092 1093. 6. [J]. 2007 16 3 355 358. WANGSH X HE Y H ZENG N 犲狋犪犾..Tooth structure imaging with optical coherence tomo graphy J. 犃犮狋犪犔犪狊犲狉犅犾狅犾狅犵狉狔犛犻狀犻犮犪 2007 16 3 355 358.inChinese 7. [J]. 2007 308 532 534. ZENG CH CH ZHENG H Q LIU H P 犲狋犪犾.. Microimaginginvivoofrattonguebyopticalcoher encetomography J. 犑狅狌狉狀犪犾狅犳犅犲犻犼犻狀犵犝狀犻狏犲狉狊犻 狋狔狅犳犜狉犪犱犻狋犻狅狀犪犾犆犺犻狀犲狊犲犕犲犱犻犮犻狀犲 2007 30 8 532 534.inChinese 8. CT [J]. 20091348 9413 9417. YAO H LIY N YAOXT 犲狋犪犾..Experimental estimateofdetectioneficacyonearlyenameldemi neralizationbythedental OCT J. 犑狅狌狉狀犪犾狅犳犆犾犻狀犻犮犪犾犚犲犺犪犫犻犾犻狋犪狋犻狏犲犜犻狊狌犲犈狀犵犻狀犲犲狉犻狀犵犚犲 狊犲犪狉犮犺 2009 1348 9413 9417.inChinese 9. [J]. 2010 14 26 4827 4830. LIY N WANG G H YAO H 犲狋犪犾..Quantitative detectionofearlyemanelartificialcariesonthesmooth surfaceusingopticalcoherencetomography J. 犑狅狌狉 狀犪犾狅犳犆犾犻狀犻犮犪犾犚犲犺犪犫犻犾犻狋犪狋犻狏犲犜犻狊狌犲犈狀犵犻狀犲犲狉犻狀犵犚犲 狊犲犪狉犮犺 20101426 4827 4830.inChinese 10 FERCHER AF HITZENBERGERC K KAMP G 犲狋犪犾..Measurementofintraoculardistancesby backscateringspectralinterferometry J. 犗狆狋犻犮狊犆狅犿犿狌狀犻犮犪狋犻狅狀狊 1995 11712 43 48. 11 XIP MEIK BRAEULERT 犲狋犪犾..Evaluationof spectrometricparametersinspectral domainoptical coherencetomographyj. 犃狆狆犾犻犲犱犗狆狋犻犮狊 2011 503 366 372. : (1963-),,,, E mail:peng cheng2007 yahoo.com. cn (1986-),,,, E mail:qinqinfh 163.com
1936 19 (1985-),,,,, E mail:okitasan yahoo. cn (1963-),,,, E mail:siweiz medmail.com.cn : (1963- ),,, Clemson,,, E mail: zgao clemson.edu (1963-),,,,SPIE Felow,OSA Felow, E mail:xcyuan nankai.edu.cn 狕 周浩 1,2, 苏伟 1, 刘显学 1, 唐海林 1 (1. 中国工程物理研究院电子工程研究所, 四川绵阳 621900; 2. 中国工程物理研究院北京研究生部, 北京 100088) 狕 1,,, U,,, 2100 m 2100 m, 60 m,, 2000,1800, 3.76o/h/Hz0.5 ±200o/s, 21mV/(o/s), 1.426%FS 1h 0.0579o/s