Sihuan Pharmaceutical Holdings Group Ltd. 0460 1
* 2,000,038 2,324,747-14.0% 1,596,023 1,847,116-13.6% 957,794 644,817 48.5% 1,007,721 699,516 44.1% 830,133 617,535 34.4% 79.8% 79.5% 41.5% 26.6% 8.011 5.966 72 50 51 42 1.3 4.3 * 14.0% 2,000.0 2,324.7 79.8% 79.5% 44.1% 1,007.7 699.5 34.4% 830.1 617.5 8.011 5.966 1.3 2
4 1,540,108 1,441,677 4 33,548 34,437 4 2,844,067 2,880,622 4 347,886 337,998 7 33,280 34,069 103,215 119,939 5 367,042 5,269,146 4,848,742 129,314 101,283 6 1,477,014 1,398,041 902,709 776,074 233,651 1,425,347 1,508,076 3,934,384 4,017,125 12 1,229,241 1,145,781 5,163,625 5,162,906 10,432,771 10,011,648 3
85,610 44,419 5,574,848 5,573,951 70,060 89,329 134,734 108,824 2,758,620 2,065,782 8,623,872 7,882,305 103,140 115,485 8,727,012 7,997,790 135,626 140,862 57,385 63,227 5,880 193,011 209,969 9 1,020,010 1,253,107 180,800 182,669 129,770 22,146 1,224,825 1,563,677 12 287,923 240,212 1,512,748 1,803,889 1,705,759 2,013,858 10,432,771 10,011,648 3,650,877 3,359,017 8,920,023 8,207,759 4
3 2,000,038 2,324,747 (404,015) (477,631) 1,596,023 1,847,116 10 13,010 7,873 10 226,044 147,245 (694,278) (1,229,015) (183,005) (128,402) 10 957,794 644,817 59,358 63,821 (8,642) (5,439) 50,716 58,382 7 (789) (3,620) 7 (63) 1,007,721 699,516 11 (175,184) (79,364) 832,537 620,152 830,133 617,535 2,404 2,617 832,537 620,152 5
14 8.011 5.966 (2,074) (1,021) 5,219 2,512 3,145 1,491 835,682 621,643 833,278 619,026 2,404 2,617 835,682 621,643 15 134,734 222,526 6
44,419 5,573,951 89,329 2,174,606 7,882,305 115,485 7,997,790 830,133 830,133 2,404 832,537 (2,074) (2,074) (2,074) 5,219 5,219 5,219 3,145 3,145 3,145 3,145 830,133 833,278 2,404 835,682 56 42,032 42,088 42,088 41,135 (41,135) 13 (38,823) (38,823) (14,749) (53,572) (108,824) (108,824) (108,824) 13,848 13,848 13,848 2,561 (2,561) 85,610 5,574,848 70,060 2,893,354 8,623,872 103,140 8,727,012 7
44,419 5,573,951 65,256 1,400,702 7,084,328 102,927 7,187,255 617,535 617,535 2,617 620,152 (1,021) (1,021) (1,021) 2,512 2,512 2,512 1,491 1,491 1,491 1,491 617,535 619,026 2,617 621,643 4,547 4,547 (300,151) (300,151) (300,151) 1,129 1,129 1,129 44,419 5,573,951 67,876 1,718,086 7,404,332 110,091 7,514,423 8
514,105 556,823 (265,102) (199,013) (306,828) (541,812) (57,825) (184,002) * 1,515,427 1,543,907 * 1,457,602 1,359,905 * 9
1. 34 1.1 2. 32 32 39 36 10
10 12 27 12 21 3. 11
4. 1,441,677 34,437 653,686 2,226,936 337,998 135,051 17,493 17,672 (36,620) (889) (54,048) (7,784) 1,540,108 33,548 617,131 2,226,936 347,886 924,052 30,894 1,027,595 2,707,435 165,637 435,744 35,404 42,519 (20,707) (828) (72,578) (2,943) 1,339,089 30,066 990,421 2,707,435 205,213 5. 12
6. 726,977 867,716 289,943 103,554 (a) 171,262 165,572 161,281 96,544 27,970 91,944 99,581 72,711 1,477,014 1,398,041 (a) 8% 8% (a) 3 438,488 632,298 3 6 129,789 105,537 6 12 149,422 129,420 12 9,278 461 726,977 867,716 13
7. 34,069 40,962 (789) (3,620) (63) 33,280 37,279 8. (i) Plenty Gold MSPEA Pharma Holdings B.V. Plenty Gold Plenty Gold 33,750,000 MSPEA Pharma Holdings B.V. 3,750,000 1 1 95 4,950,337 14
(ii) 3.19 14,150 3.19 19,750 0.70 2,050 35,950 3.19 25,100 7,484 0.70 2,050 3.19 (4,950) (1,134) 0.70 3.19 20,150 0.70 2,050 44,400 6,350 (a) 1 1 Plenty Gold Enterprises Limited 1 1 8.37 15
3.19 4,168 6,350 0.70 4,100 3.19 36,132 44,400 5,900 9. 69,939 36,555 233,341 395,335 193,590 193,590 158,372 229,969 100,235 74,664 47,970 47,970 24,800 51,200 23,424 36,638 9,653 34,594 158,686 152,592 1,020,010 1,253,107 6 52,409 29,287 6 12 10,262 1,203 1 7,268 6,065 69,939 36,555 16
10. 11,073 6,542 1,937 1,331 13,010 7,873 224,154 151,333 2,074 1,021 1,297 (184) (6,406) 226,044 147,245 637,078 1,161,706 99,341 97,056 43,496 31,105 11. 163,696 121,598 (a) (122,751) 163,696 (1,153) 11,488 (1,080) (a) 81,597 11,488 80,517 175,184 79,364 17
(a) 15% (b) (i) (ii) (iii) 25% 15% (iv) 10% 10% 5% 18
12. 637,500,000 50% 19% 31% 50% 19% 242,250,000 100,000,000 19% 193,590,000 60 6 752,233 314,840 8,546 77,170 32,255 44,197 1,229,241 222,732 65,191 287,923 941,318 19
13. 49% 53,572,000 14,749,000 14,749,000 38,823,000 14,749 53,572 38,823 14. (a) 830,133 617,535 * 10,362,542 10,350,048 8.011 5.966 * (b) 20
15. 108,824,000 1 1 0.01 1.3 4.3 134,734,000 (I) 34.4% 14.0% 10.8% 21
(i) (a) 94.0% (1) (2) (3) 30% 50% 20% 16.1%GMP 3.8% GM1 7.0% 17.0% 79.0% IMS * (1) 687,027 655,490-4.6% 34.7% * 582,264 377,934-35.1% 14.3% 80 * 67,969 88,171 29.7% 320 * (2) 202,043 184,403-8.7% 58.2% * B(II) 129,435 79,864-38.3% 53.0% * 22
(3) 92,711 122,467 32.1% 57,121 91,507 60.2% GM1 96,790 90,026-7.0% 45,849 47,585 3.8% 48,240 40,061-17.0% 33,043 38,354 16.1% 151,180 31,677-79.0% 5,296 8,545 61.3% (1) (2) (3) (b) 23
41.1% 32.6% 6.5% 15.5% 6,325 8,921 41.1% 34,792 40,184 15.5% 26,684 28,415 6.5% 7,858 10,415 32.6% 2,485 9,974 (ii) 20 15 8 24
GM1 1,118 GM1 PC12 60% 2,745 2,665 73 8 25
(iii) 1.1 CXHL1400849 CXHL1400850 1.1 SGLT2 2 II SGLT2 SGLT2 1.1 I 1.1 FDA ( IND ) (BisoprololFumarate) (Losartan Potassium) (Lansoprazole) (Esomeprazole) (Fasudil Hydrochloride) (Octreotide Acetate) (Vinpocetine) (FlurbiprofenAxetil) (Oxiracetam) (Esomeprazole Sodium) (Caspofungin Acetate) 3 (Levetiracetam Injection) (Lacosamide) Ornithine Aspartate Injection Hepa- Merz (Rivastigmine Hydrogen Tartrate Capsules) (Caspofungin Acetate for Injection) (Flupirtine Maleate Capsules) (Divalproex Sodium Tablets) (Revaprazan Hydrochloride) ((R) Lansoprazole) 26
1.3 L-Phencynonate Hydrochloride III IV (Cinepazide Mesilate) II NeuroVive PharmaceuticalAB to-bbb technologies B.V. G20 (ImigliptinDihydrochloride) (Anaprazole Sodium) 7.42 (iv) GMP FDA FDA FDA Apotex Inc. Dr. Reddy s Laboratories Ltd. 1,000 Posaconazole ZaCh System S.p.A. Taro Pharmaceutical Industries Ltd. 27
(II) (i) (ii) (a) 28
(b) (c) 29
(iii) 2,000.0 2,324.7 324.7 1,880.8 334.0 94.0% 18.5 18.8% 15.0 0.8% 16.7% 99.1 5.0% 30
404.0 20.2% 1,596.0 1,847.1 251.1 79.5% 79.8% 147.2 226.0 534.7 694.3 128.4 42.5% 183.0 58.4 13.1% 50.7 699.5 44.1% 1,007.7 31
175.2 620.2 34.3% 832.5 617.5 34.4% 830.1 1,425.3 1,508.1 233.7 902.7 776.1 897.5 897.5 5.2 902.7 454.5 32
1,425,347 1,508,076 (186,680) 1,425,347 1,321,396 1,477.0 1,398.0 79.0 129.3 101.3 51 42 1,540.1 98.4 6.8% 33
2,844.1 2,880.6 1,020.0 233.1 34
431.5 107.3 77.5 246.7 35
2,726 127.3 76.7 A.2.1 36
1 1 5,182,091,103 5,182,091,103 1.3 1.7 4.3 37
183 22 (http://www.hkexnews.hk) (http:// www.sihuanpharm.com) (http:// www.sihuanpharm.com) (http://www.hkexnews.hk) 183 22 sihuanpharm-ecom@hk.tricorglobal.com 38