Ps22Pdf

Bis marck

aging Se nility

DNA DNA DN A DN A Orgel DN A RN A DNA RN A H arman Bjoxksten

T programeol cell death PCD X

P

vitb

ml

T T RH P T H Ca P T H T T

T

R Bocon Nascher Geriatrics

A

genetic program theory modifier genes theory codon restriction theory

DN A DN A DN A DN A cross linkage theorr free radicals DNA DN A DN A Y

point mutation chromosomal mutation genomic muta tion transition transversion insertion deletion basesu bstitution frame s hift mutation somatic mut ation theory

lipofuscin DNA

H R R H R H free radicals O O H O H H R RO ROO L L O L O O O O H reactiveoxygen species ROS O O H O O H O O H O Poeggeler H O O H nm H O O H DM PO O H DMPO O H O H O O O O DNA

N D NMDA Ca Ca O H O Peruche I FN TN F TN F burst erythrocyte diformability micro plugs

DNA MDA H O Kainate DN A

apoptosis necro sis programed cell edath PCD ROS ROS

ROS ROS burst ROS P ROS DN A H O mol L mol L H O H O TN F IF N GM CSF IL DNA DN A DN A

c myc c fos c myc c myc bcl c myc c fos bcl bcl Kda P P NDA DNA mtdna bp DNA mtdna mtdna r RNA

S S trn A B C I ATP N ADH ND ND ND L M tdn A mtdn A mtdna DN A nda N mtdn A mtdna ndn A mtdna mtdn A mtdn A mtdna mtdn A mtdn A mtdn A mtd NA mtdn A

mtdn A mtdna mtdn A mtdn A OSP H OS mtdn A Lerbe Lerbe s hereditary optic neu ropathy mtdna G A N AD H ND mitochondrial mypathy encephalopathy lctic acidosis stroke like episodes mtdna trnaleu A G mtdn A mtdna mtdn A

mtdn A OXP H OS mtdn A mtdn A mtdna mtdn A mtdna mtdn A mtdna mtdna mtdna mtdn A mtdn A OXP H OS OX P H OS mtdna mtdn A Wallace k b kb mtdn A OXP H OS mtdn A

M tdn A mtdna ATPase D kb mtdn A mtdn A mtdn A OXP H OS M tdn A Parkin son PD Alzheimer AD Hun tington HD OXP H OS mtdna PD PD I I mtdna mtdn A kb mtdna AD mtdna T OXP H OS Parker AD IV OXP H OS AD

OXP H OS mtdn A AD mtdna OXP H OS HD H D IV I HD H D mtdn A M tdn A OXP H OS OX P H OS mtdn A k bmtdn A L O rrn A ND cytb RN A mtdna mtdna OXP H OS mtdna mtdna A G trn ALeu ATP M tdn A

mtdn A OX P H OS mtdn A ATP mtdna PCR Southern Q mtdn A mtdn A mtdna te lomere telomerase RNA CD T

B T B B T B

B T T K T T T H T B T H T M T B IgG IgA IgG IgA T s B IgM IgD IgE

M Walford DN A H LA HLA A B C D Dr H LA A HLA B H LA Dw H LA B HLA Dw Imuran B polyanion s E T T

maximun life span Caenorhabditis elegans age Age C elegans H O C elegans C elegan s clk daf daf Daf C elegans Clk

Clk C elegans Clk daf clk C elegans daf clk senescence associated gene SAG DN A senescent cell derived inhibitor of DN Asynthesis Werner WRN WRN E Alzheimer Disease AD EF

E F SOD Rose SOD melatonit MT MT M T MT

M T M T MT M T MT MT MT MT MT M T MT mrn A M T MT MT DN A MT MT MT MT Fe I Zn Cu Mn Se Cr Mo Co F Sr Sn Ni v

Zn Mn Se Cr GSH pk H DL C SOD IgA Zn Mn Se Cr Co Ge V Cr Mn Ni Zn Se Zn Mn Se Cu

DN A mrn A cdn A cdna DN A cdn A Northern Northern Northern YAC cosmid phage YAC DN A Northern

YAC cosmid phage cdn A cdn A cdn A DN A cdna PCR cdna cdn A cdn A DN A PCR cdn A DN A DN A cd NA DN A CpG NotI Zoo blot DN A cd

NA cdna DN A DN A DNA DNA open reading frames tech nology of the repertoire of antibodies displayed on phages by passing immunization and hybridoma HBsA G H TV ScFv

ribozyme m RNA HBV HCV HIV RN A RN A

SIgA

T NK IL T B NK NK NK N K NK T T T T CTL TH T B B cytokin IL CSF I FN TN F TGF LIF

C X

Mycoplasma Pneumonia M P X Noscomial Pneumonia N P

X G g mg g g g g g

G mg

Osteoporosis I Bone Remod

eling CT P T H O H D CT C P T H O H D P T H O H D P TH C CT I IGF I IG F I O H D IGF I

P T H Ca P K BMD D O H D D D VDR BBA A BMD TGF

I P T H T T D D O H D O H D P T H mg P T H

D K Ca O H D BB BMD bb

cm mm cm Colles BMD DS X

BMD I A KP A KP A KP A KP A KP AK P BG P O H D BGP BGP PGP

BGP I PICP PICP P ICP PICP H OP h d H OP H O P H OP H O P H OLG H OP T RAP T RA P T RAP PYr I N N TX H OP mmol L mg dl D

P Ca D D h h X X X SPA

BMC g m BW cm BMD g cm X DEXA X BMC AREA BMD DEXA QCT C T QCT X U SA DXA I II

D K P T H CT O H D TG FB mg d mg mg d mg mg Livial mg CT P T H Vit D

O H D Ca mg d C T Ca P TH Vit D Ca C T C T U U Elcatonin CT U U U Ca U d CT Miacalcic U U U ml CT CT CT C T Vir D Ca P T H Vit D O H D Vit D Ca Vit D VD O H D g

D Alfacalcidol O H D O H D g d Ca mg g Ca g g g g g D mg Vit D U P T H E H T P

Bonefos mg mg Disoduum E tidrona te mg mg d mg ml Ipriflavone CT Osten C T mg C T Oxandrolone mg d mg mg Vit K mg d mg Vit D Ca

Vit D Ca P Vit D Ca P ml Ca mg

Vit D CT Ca Vit D P TH C T Vit D

Alzheimer AD AD AD AD AD AD AD AD Vascular Dementia VD

Multl infarct Dementia MD AD Down AD apoe AD apoe apoe AD Corder AD apoe AD SP N F T AD Scapie K wru Creutzfeldt Jacob C J AD

AD AD AD H T P AD AD AD NF T SP AD SP N F T SP SP IgG IgG

c s CT MRI prsyophre nia Paxa bcknn AD AD

CT AD SP N F T SP N F T SP NF T SP NF T DSM IV W H O ICD NICFS ADRDA AD NF T tau phos pho ryltedneurofilament PNF P H F CT MRI P ET

CT MRI ml GuZu SOD CT MRI AD M ABP ABP AD FDA AD tacrine t E donepezi aluminum chelating agent deferoxamine NSAIDS

AD AD AD AD

mm

Iron Defieiency Anemia Plummer Vinson MCV m g dl mg ml g g C

mg g dl g d mg Megaloblastic Anemi a B DNA S Vit B B Vit B

PAS Vit B B mg B MCV m ng ml ng ml B Pg ml mg B B g g Aplastic Anemia H emolytic Anemia

h

B X CT

Flunariaint

arteriosclerosis atherosclerosis AS fat ty Streak

AS VLDL H DL LDL LDL ch Tc TC LDL Ch C HD AS CH D Tc CH D CH DL ch CH D TG C HD AS AS AS H DL

H DL H DL LDL HDL CH D VLDL A TXA TXA PGI TXA AS AS AS

X CT A

P TCA mg mg dl TC TG PL F FA F FA LP

H DL LP LDL LP VLDL pre LP CM Apo A B C D E F G H J H DL H DL H DL Apo A Apo AI Apo AII Apo B Apo B Apo B Apo C Apo CI Apo C Apo C AS CH D CH D NE P C HD T C mg dl mg dl mg dl CH D HDL C mg dl H DL C CH D TG mg dl mg dl mg dl mg dl LDL C mg dl mg dl

T C mg dl TG mg dl CH D HDL C mg dl H DL C T C mg dll TG mg dl AS T C CH D M RFIT TC mg dl CH D TC mg dl mg dl mg dl COX CH D TC mg dl mg dl CH D TC mg dl TC CH D LDL TC LDL C LDL C mg dl mg dl mg dl mg dl CH D CH D LDL C HDL

HDL C mg dl mg dl mg dl CH D HDL C C HD TG CH D TG CM VLDL LDL H DL C AS CH D LDL C HDL C TG CH D a L P a CH D LDL Apo a L P a CHD L P a C HD LP a LDL C HD LP a CH D L P a L P a mg dl CH D mg dl LP a LP a AS Apo AI Apo A II AS Apo B LDL AS Apo AI Apo B

T C TG TG TC TG TC TC LDL TG Apo B H DL Apo AI TC H DL C TC LDL TC mg dl C C T C

T C C LDL C H DL C e e C EP Q C e D H A C e TC LDL C TG mg TC g kcal LDL C mg dl TC LDL CTG T C H DL C H DL C g d TC HDL C TG TC HLD C H DL C H DL C TC T C TC TG H DL C TC LDL C HDL C TG

TC TC TG HDL C TG H DL C TC H DL C TG H DL C TC H DL C TC mg dl TG mg dl HDL C mg dl LDL C mg dl HDL C T C TC TG TC TG H DL C TC HDL T C Fredrick son W H O I a b H DL C

Targier Apo AI Apo C LACT LP L Apo C AS CH D TC TG TC TG HDL C H DL C T C mg dl LDL C mg dl F H LDL C CH D F H LDL LDL T C mg dl TC mg dl LDL C mng dl F H TC mg dl

CH D AS TG TG mg dl LPL FC H CH D T C TG VLDL Apo E Apo E Apo E VLDL LDL CM VLDL TC TG C HD VLDL Apo E Apo E Apo E L PL Apo C CM CM TG TG CM LPL Apo C H DL C H DL C H DL C

HDL C Apo B LP a CH D TG CM VLDL CM CM CLDL TC TG HDL C LDL C LDL C F riedewald TG mg dl LDL C LDL C TC H DL C TG mg dl TC H DL C TG mmol L b H DL VLDL LDL CM

LP L LP L CM L PL TG CH D T C F H CM VLDL VLDL F H TC X mm mm LDL CM TG TG CM TG mg dl AS CH D

AS CH D kpa mm Hg H DL C mg dl HDL C mg dl NCE P LDL C k d d d

mg d mg d g TG TC H DL C h

C HD AS CH D Chesty amin Co lestipol Nicotinic Acid Inositol Nicotinate Acipimos Olbetam Begafibrafe Gemfibrate Lopid Fenofibrate Ciprofibrate Etofylline Clofibrate Clofibrate P robucol H M CoA A Lovastafin Simvst atin pravastitn Fluvstatin T C

T C LDL LDL T C H DL C g d VLDL TG g d LDL LDL C HDL C TC LDL d g Q T H DL C Elastase T C

d U T C TG HMG CoA H MG CoA LDL LDL mg mg T C T C LDL C TG H DL C ALT CPK HMG CoA TC LDL C TG H LD C TG T C VLDL TG VLDL H DL H DL TG

TG TC LDL C HDL C g d g d g d g d AL T CK H MG CoA CoA VLDL LP L CM g d TC TG LDL C H DL C d g TG H DL C TG TC AS d g TG TC H DL

C TG Omega EPA D H A TG TG g d g d AS LP a LP a

g g g g

C B B B B C

A B C

g g g g g g g g g g g

g g g g g g g g g

g g g g ml g g g g g g g g

g g g g g g g g g g g g ml ml g

g g g g g g g ml ml g g g ml g g g g g g g g g

g g g ml g g g g

g cm cm g g g g

g g g g g

g g g g g g g g g g g cm cm

g ml g g g

g g g g g

ml g

g g g g

g g g g g g g g

g g g g g g g g

E

g g g g g g g g g

ph ph p H

A C B B

A D E