(Adrenocortical Hormone Agent)?????????????????
(Adrenocortical Hormone Agent) (Mineralocorticoids) (aldosterone); - (Renine-Angiotensin) (Glucocorticoids) (cortisol); ACTH (Adrenocorticotropic Hormone), (Sex Hormones)
(glucocorticoids GC) ( Steroids), A B C D C 3 C 4 5 C 20
(cortisone) (hydrocortisone) C17 C11
* C 1 2 prednisone; prednisolone) * C 9 C 16 dexamathasone);
. 90% 80% transcortin, corticosteroid binding globulin, CBG) 10% GC Why? A C4-5 ; Why?
C C11
90% 48 17-17- GC <12h 12 36h >36h
5. 6. ACTH GC
1 1 PLA 2 AA PGE 2 PGI 2 LT ACE (angiotensin converting enzyme)
(interleukin, IL)-1-6 11-13, (tumor necrosis factor, TNF) IL-10 IL-1 ; NOS NO
2.
3. 1 2 4. myocardial depressant factor MDF
5. * ( * 6. * 7. *
[ ] GCs GCR GCs DNA DNA Tau 1 / - N C
1 GCR GCR HSP90 HSP70 GC GC-R HSP90 GC GC-R GC-R DNA promoter) (glucocorticoid response element, GRE; negative glucocorticoid response element, ngre) mrna
2 GC-R GCs GC-R (transcriptional intermediary factors, TIF) (co-regulators) -kb (NF-kB) (activator protein-1, AP-1) IL-2 IL-4 IL5
1. Addison s 2. * * GC * *
3. 4. 5. 6.,
1. (1) cushing syndrome (2) (3) (4) (5) (6)
2. (1) * GCs - - ACTH * * GC (2)
*
(aldosterone) - (Renine- Angiotensin)
(Corticortropin, Adrenocorticotropic Hormone ACTH) 39 GCs -
(Adrenocorticol Hormone Inhibitors) (mitotane o p -DDD): DDT GCs