[1]
: Willis : :
.1 Willis Willis Willis Willis Willis [10-18] 18] Willis Willis
[19 20] 1 1 mm 1 1 mm ( 1 1 mm) [21] [22] [23]
Willis Willis [24 25] 25]
3.2 10 s s 8 9 10 10 [32]
11 11 [31] [31] [26]
[31] [33]
3. 6 1 1 s s 6
3. 7 (1) (2) (3) 2 MCA
CTA MRA DSA Willis DSA TCD Willis
Xe-CT SPECT PET CT MR MTT CT MRI MRI FLAIR 12
DSC DSC-PWI, [30] CO2 CO2 TCD TCD
2 27.8 11.3 TIA TIA [38]
10 10
1. 2. 3. 4.
Liu CL, Liao SJ, Zeng JS, et al. dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP. Journal of the Neurological Sciences. 2007;260:106-113.
PGI 2 /TXA 2 6-keto-PGF 1 TXB 2 Acta Pharmaceutica Sinica 1998,33(12):881-885
, 20mg/kg 40-70 m 1999 34 3 172 175
*** *** *** *** ischemia *** p<0.001 1999 34 3 172 175 27
VEGF A 8 RHRSP 80mg/kg/ 2 / 10 B 16 RHRSP 80mg/kg/ 2 / 10 C 8 RHRSP D 16 RHRSP * p<0.01 # P<0.05 28
NBP NBP FITC A D vwf E F 200 20 m Liu CL, Liao SJ, Zeng JS, et al. dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP. Journal of the Neurological Sciences. 2007;260:106-113.