PROTEOL APL 1
1-3 2-3 3-4 3-1 4 3-2 5 4-8 4-1 8 4-2 9 4-3 10 5-11 6-10 7-11 8-12 9-12 10-12 2
1 - PROTEOL APL PROTEOL APL 2 - PROTEOL APL - PROTEOL APL - PROTEOL APL PROTEOL APL - PROTEOL APL ( ) PROTEOL APL 3-3.1-10 ( 1) PROTEOL APL - ( ) ( ) - PROTEOL APL ( 3.2 ) - 3
Softness of the foam Ease of rinsing Softness on the skin Stability of the foam Abundance of the foam Density of the foam 1 PROTEOL APL 1 PROTEOL APL 3000 rpm 2 min 0.1% 40 C ph 7 15x 10 30 3.2 - PROTEOL APL Ross-Miles PROTEOL APL 4
3.2.1 - ( 2 ) PROTEOL APL 600 548 596 500 400 462 444 300 262 288 (ml) 200 100 0 169 PROTEOL APL NaLES Sodium lauroyl sarcosinate 10 Sodium lauroyl glutamate + 2 Ross-Miles (ISO 696-1975, AFNOR NFT 73-404) 1% ph 7 PROTEOL APL 5
3.2.2 - NaLES PROTEOL APL 1% PROTEOL APL ( 3 ) Foam in hard water + dirt 500 400 408 Foam volume (ml) 300 200 100 0 262 NaLES 242 NaLES + Sodium lauroyl glutamate NaLES + PROTEOL APL 3 (NaLES/ : 9/1% ) Ross-Miles (ISO 696-1975, AFNOR NFT 73-404) - 1% PROTEOL APL 6
4 - PROTEOL APL PROTEOL APL 4.1 - PROTEOL APL (SEPPIC 57CO009 annex IV of the order of 29 November 1996 published in the JO no. 300 of 26/12/96, page 19137). HET-CAM: Dose-response comparison of anionic surfactants 12 10 8 6 4 0.1% a.m. 0.5% a.m. 2 0 PROTEOL APL Sodium lauroyl sarcosinate NaLES 4: HET-CAM : 0.1% 0.5%. Note: The results obtained by the HET-CAM method are comparable with the results obtained by the Draize test (in vivo method) at 10-fold higher concentrations. 7
PROTEOL APL ; 0.5% PROTEOL APL 5. (SEPPIC HET-CAM 2355-2585-2604). 4.2 - PROTEOL APL (RBCA) RBCA Surfactant-induced denaturation of oxyhemoglobin 100 % denaturation 80 60 40 20 5% am 10% am 0 NaLES PROTEOL APL Graphe n 5 : Evaluation du pouvoir dénaturant vis-à-vis de l oxyhémoglobine : 540 575 nm : OD 575 nm/od 540 nm; PROTEOL APL : SEPPIC toxrbca995. 8
(SEPPIC 57CO002) NFT 73-420 (ISO 8022 190 amended) 6 PROTEOL APL NaLES 25 C 0.1% Assessment of wetting power 120 100 80 time (seconds) 60 40 20 0 PROTEOL APL NaLES PROTEOL APL NaLES 6: PROTEOL APL NaLES PROTEOL APL 4.3 - PROTEOL APL FINNCHAMBER 5 10 20 48 PROTEOL APL (DERMSCAN 1040067) 9
PROTEOL APL PROTEOL APL (Chapter 5.1.3 4th edition, January 2002 Effectiveness of microbial contamination Criteria A, refer to MIDAC expert report 03 365 289). PROTEOL APL 5 - PROTEOL APL 301 B PROTEOL APL 28 95% (i.e. > 60%). PROTEOL APL 6 - PROTEOL APL 10% PROTEOL APL 10
PROTEOL APL PROTEOL. APL - PROTEOL APL ph 7 - NaLES PROTEOL APL ph 5 PROTEOL APL PROTEOL APL - NaCl - ( CAPIGEL 98, SEPPIC 6857) - ( AMONYL 380 BA, SEPPIC 6958) - ( MONTALINE C40 SEPPIC 6960) - 7 - ( 1996 12 26 ) 0.1%, 0.5% 0.8% ph 7 PROTEOL APL 0 NaLES (0.1% ) (0.5% 0.8% ) SEPPIC HET-CAM 2355-2585-2604. PROTEOL APL ph 7 5% 10% 20 48 PROTEOL APL (DERMSCAN 1040067) MARZULLI MAIBACH. 11
8-2406601 2406602 (as is) Max. 150 Hazen 2406603 ph (as is) 6.5-7.5 2406604 28-32% 2406605 2-5% 2406606 Max. 100 /g 2406607 / Max. 100/g 2406607 9 - INCI Sodium Cocoyl Apple Amino Acids CAS 68188-38-5 10 - PROTEOL APL - - - - - SEPPIC PROTEOL APL 12
EXTRA-GENTLE CLEAR BABY SHAMPOO 6957 Formula A ORONAL LCG (Sodium coceth sulfate and PEG40 glyceryl cocoate 13.0 % SEPPIC) PROTEOL APL (Sodium cocoyl apple amino acids SEPPIC) 7.0 % SEPICIDE HB (Phenoxyethanol/Methylparaben/Ethylparaben 0.3 % /Propylparaben /Butylparaben - SEPPIC) Parfum / Fragrance 0.2 % B CAPIGEL 98 (Acrylates copolymer SEPPIC) 3.5 % Aqua / Water 10.0 % C Aqua / Water Qsp 100 % D Triethanolamine 0.65 % SEPICIDE CI (Imidazolidinyl urea - SEPPIC) 0.2 % E Sodium chloride Qs Procedure Weight all the ingredients of phase A and mix well after adding each of them. Mix the ingredients of phase B and add it to phase A. Add phase C and D (the ph is adjusted to 7.2 with the Triethanolamine). If necessary, the viscosity is lowered with the addition of phase E (1% max). Comments ORONAL LCG PROTEOL APL CAPIGEL 98 SEPICIDE HB SEPICIDE CI Ultra mild surfactant that is extremely well tolerated by skin and eyes. It is well suited for formulation of products that require perfect tolerance (makeup removers, products for babies or sensitive skin, etc.). It allows formulation of colourless products. Fruit surfactant, derived from apple juice essential amino-acids, for a gentle approach : gentle approach for the touch, for the skin & the eyes and also for the environnement. CAPIGEL 98 is a liquid thickener that is used at ph7. CAPIGEL 98 is especially useful to thicken low-concentration surfactant systems such as foaming facial cleansers, products for babies and intimate hygiene gels. CAPIGEL 98 can also be used to obtain perfectly clear and colorless skincare gels. Preservative. Preservative. 13
Characteristics Aspect Clear ph Around 7.2 Viscosity Around 4,000 mpa.s / Brookfield LV2 6rpm Stability Stable at RT 40 C 4 C Assessment HET-CAM test at a 10% dilution: score = 0 / non irritant (SEPPIC method 57CO009) Notes Fragrance : Musty Ref PN002307 (QUEST) 14
MOISTURIZING CLEANSING FRUIT WIPES 6959 Formula A PROTEOL APL (Sodium cocoyl apple amino acids SEPPIC) 02.00 % AQUAXYL (Xylitylglucoside and anhydroxylitol and xylitol SEPPIC) 01.00 % B SEPICIDE HB2 (Phenoxyethanol/Methylparaben/Ethylparaben 00.50 % /Propylparaben /Butylparaben/Isobutylparaben - SEPPIC) Parfum / Fragrance 00.05 % Hexylene glycol 10.00 % C Aqua / Water Qsp 100 % Procédure Mix ingredients from phase B until the mixture becomes clear, then add phase A, then C. Comments PROTEOL APL Fruit surfactant, derived from apple juice essential amino-acids, for a gentle approach : gentle approach for the touch, for the skin & the eyes and also for the environnement. AQUAXYL New "AQUACONCEPT " technology : thanks to an harmonization of the skin's hydrous flow, AQUAXYL TM moisturizes and restructures the skin ; Water reserves are instantly boosted and water loss is reduced (in vitro and in vivo proven efficacy) for a more supple and resilient skin!" SEPICIDE HB2 Preservative Characteristics Aspect Clear, colorless lotion ph around 7 Viscosity < 50 mpa.s Brookfield LV Stability Stable at RT and 40 C Notes Fragrance : Paradise 462155 (SYMRISE) 15
TWO-PHASE SHOWER GEL «GREEN APPLE» 6958 Formula A Sodium laureth sulfate 14.0 % PROTEOL APL (Sodium cocoyl apple amino acids SEPPIC) 5.0 % AMONYL 380BA (Cocamidopropyl betain SEPPIC) 5.0 % Glycerin 0.8 % Parfum / Fragrance 2.0 % MONTANOX 20DF (Polysorbate 20 SEPPIC) 0.5 % SEPICIDE HB (Phenoxyethanol/Methylparaben/Ethylparaben /Propylparaben 0.3 % /Butylparaben - SEPPIC) SEPICIDE CI (Imidazolidinyl urea - SEPPIC) 0.2 % Colorant / Dye 0.01 % Aqua / Water Qsp 100% B Polyisobutene 22.0 % C Lactic acid 0.1 % Procedure Solubilize Sodium laureth sulfate in the water then add the ingredient of phase A, mix well after adding each of them. Introduce phase B into phase A under moderate stirring. Adjust the ph with C component. Comments PROTEOL APL AMONYL 380BA MONTANOX 20DF SEPICIDE HB SEPICIDE CI Fruit surfactant, derived from apple juice essential amino-acids, for a gentle approach : gentle approach for the touch, for the skin & the eyes and also for the environnement. Amphoteric co-surfactant. Solubilizing surfactant. Preservative. Preservative. 16
Characteristics Aspect Bi-phasic solution : green phase on the bottom white phase on the top ph around 6 Viscosité < 50 mpa.s Stability Stable at RT 40 C 4 C Notes Dye : Vert Ref W7000 (WACKHERR) Fragrance : Pomme Granny Ref X024720 (QUEST) 17
ENERGIZING CLEANSING GEL 6960 Formula A Sodium lauryl sulfate 5.9 % Aqua / Water Qsp 100 % B PROTEOL APL (Sodium cocoyl apple amino acids) 5.0 % MONTALINE C40 (Cocamidopropyl betaïnamide MEA chloride SEPPIC) 5.0 % SEPITONIC M3 (Magnesium aspartate & Zinc gluconate & Copper gluconate 1.0 % SEPPIC) Parfum / Fragrance 0.1 % KATHON CG (Methylchloroisothiazolinone and methylisothiazolinone 0.08 % distribué par SEPPIC) C Lactic acid 0.15 % Sodium chloride 0.8 % D Colorant / Dye 0.05 % E Sodium chloride Qs Procedure Mix phase A under extractor hood. Mix ingredients from phase B and introduce phase A into phase B. Add phase C and D. If necessary, the viscosity is increased with phase E (1.5% max). Comments PROTEOL APL MONTALINE C40 SEPITONIC M3 KATHON CG Fruit surfactant, derived from apple juice essential amino-acids, for a gentle approach : gentle approach for the touch, for the skin & the eyes and also for the environnement. Polyvalent quaternised coconut oil: foaming agent and extra-fluid thickening agents that is easy to use (it is incorporated at cold temperatures or at any step of the process). It is the ideal cosurfactant of sodium lauryl ether sulfate. It combats dryness and has also a dermo-protector effect. Multimineral chrono-energizer. Its zinc, copper and magnesium content helps stimulate the cells by increasing the energy profile (Pyruvate, ATP) and overall metabolism (DNA, proteins). Ideal for tired skin, SEPITONIC M3 delivers the elements needed for cell dynamism and the maintenance of skin function. It works to stimulate cell regeneration and helps restore fresh, radiant skin. Preservative. 18
Characteristics Aspect clear and blue liquid ph around 6.0 Viscosity around 3,500 mpa.s / Brookfield LV2 6rpm Stability Stable at RT 40 C 4 C Notes Fragrance : Délice figue Ref RS12021 (TECHNICO FLOR) Dye: Bleu azur Ref W6004 (WACKHERR) 19
GENTLE SKINFEEL FOAM 6970 Formula A Sodium laureth sulfate 21.00 % PROTEOL APL (Sodium cocoyl apple amino acids SEPPIC) 5.00 % SEPICIDE HB (Phenoxyethanol/Methylparaben/Ethylparaben /Propylparaben 00.30 % /Butylparaben - SEPPIC) Parfum / Fragrance 00.10 % Aqua / Water QSP 100 % SEPICIDE CI (Imidazolidinyl urea - SEPPIC) 00.20 % B Lactic acid 0.15 % Procedure Add ingredients of phase A and mix well after addinf each of them. Then, add phase B. Comments PROTEOL APL Fruit surfactant, derived from apple juice essential amino-acids, for a gentle approach : gentle approach for the touch, for the skin & the eyes and also for the environnement. SEPICIDE HB - CI Preservatives Characteristics Aspect Clear colorless solution ph around 6 Viscosity < 50 mpa.s Brookfield LV 2 Stability Stable at RT / 40 C / 4 C Notes Fragrance : Délice Figue RS 12021 (TECHNICO FLOR) 20
Nota The analytical specifications warranted are only those mentioned on the certificate of analysis supplied with each delivery of the product. Except as set forth above, SEPPIC* makes no warranties, whether express, implied or statutory, as to the product which is the subject of this document. Without limiting the generality of the foregoing, SEPPIC* makes no warranty of merchantability of the product or of the fitness of the product for any particular purpose. Buyer assumes all risk and liability resulting from the use or sale of the product, whether singly or in combination with other goods. The information set forth herein is furnished free of charge and is based on technical data that SEPPIC* believes to be reliable. It is intended for use by persons having technical skill and at their own discretion and risk. Since conditions of use are outside SEPPIC*'s control, SEPPIC* makes no warranties, express or implied, and assumes no liability in connection with any use of this information. Nothing herein is to be taken as a license to operate under or a recommendation to infringe any patents. * SEPPIC being : and, depending on the country : SEPPIC S.A. SEPPIC UK Ltd SEPPIC ITALIA Srl 75, quai d Orsay 50 Salisbury Road Via Quarenghi 27 75321 Paris cedex 07 PO Box 338 - Hounslow 20151 Milano FRANCE TW4 6SH - ENGLAND ITALY Tel. : +33 (0) 1 40 62 55 55 Tel. : +44 208 577 8800 Tel. : +39 02 38009110 Fax : +33 (0) 1 40 62 52 53 Fax : +44 208 570 2106 Fax : +39 02 38009140 GIVAUDAN LAVIROTTE S.A. SEPPIC Inc. SEPPIC Chine 56, rue Paul Cazeneuve 30, Two Bridges Road, suite 210 Room 510 Jin Tai Building BP 8344 69008 Lyon Fairfield, New Jersey 07004-1530 58 South Mao Ming Road FRANCE USA Shanghai 200020 CHINA Tel. : +33 (0) 4 78 61 55 00 Tel. : +1 973 882 5597 Tel. : +86 (21) 64 66 01 49 Fax : +33(0) 4 72 05 60 89 Fax : +1 973 882 5178 Fax : +86 (21) 64 66 11 09 SEPPIC GmbH SEPPIC Belgium NV ABC Tower Köln Nieuwe Weg 1 Ettore - Bugatti - Str.6-14 Haven 1053 51149 Köln-Porz B 2070 Zwijndrecht GERMANY BELGIUM Tel. : +49 (0) 220 3890 3100 Tel. : +32 3 250 3911 Fax : +49 (0) 220 3890 3199 Fax : +32 3 250 3912 www.seppic.com Subsidiary of the AIR LIQUIDE group C/2582/GB/01/May 2004 21