2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 1. 1. 2 500 730 2 5 1 1 1. 1. 3 739 127 116 712 265 3 143 50 2 2 1 13 2 14 3 15 4 16 5 17 6 18 7 19 8 20 9

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 1006-446X 2011 12-0001-28 1 2 2 1. 201800 2. 510070 R 244. 9 A 1 1. 1 3 2000 1. 1. 1 1973 3 52 299 31 136 100 32 1 13 2011-10 -20 1

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 1. 1. 2 500 730 2 5 1 1 1. 1. 3 739 127 116 712 265 3 143 50 2 2 1 13 2 14 3 15 4 16 5 17 6 18 7 19 8 20 9 21 10 22 11 23 12 24 2

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 2 25 38 26 39 27 40 28 41 29 42 30 43 31 44 32 45 33 46 34 47 35 48 36 49 37 50 1. 1. 4 1578 1596 52 2 3 361 591 1 892 1 1 16 60 4 1 61 40 21 3 3 3 28 1 1 1 1 21 2 61 4 31 13 12 5 3 61 174 58 32 58 16 4 61 202 96 24 65 17 4 3

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 4 9 14 0 1 0 1 17 5 3 1 0 1 10 7 0 1 9 9 0 2 0 1 0 1 0 1 0 1 0 2 0 1 0 3 1 1 0 1 1 2 0 2 0 1 0 1 5 2 0 1 8 5 0 2 3 3 0 1 6 10 4 1 6 6 1 1 20 9 0 1 12 8 8 3 0 2 0 1 0 1 6 6 0 1 0 5 0 2 0 1 1 1 0 6 5 10 0 3 5 12 0 1 0 1 0 2 0 1 17 13 7 5 0 2 6 5 1 2 3 5 0 1 4

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 5 21 5 5 1. 1. 5 40 600 200 1802 921 716 5 18 6 5

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 6 3-4 1. 2 1. 2. 1 1 2 3 4 5 6 1. 2. 2 7 6

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 7 7

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 3-4 1. 3 1. 3. 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1. 3. 2 1 2 3 4 5 6 7 8 1. 3. 3 1 2 3 4 5 6 8 7

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 8 9 10 11 1. 3. 4 1 2 3 4 5 6 7 8 2 1 2 3 4 5 2. 1 1950 1979 20 50 60 1955 205 1956 1958 1959 1955 1960 1958 6 7 8 3 38 ~ 40 41 ~ 9

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 43 44 ~ 46 1 15 ~ 20 min 55 3 ~ 5 mm 20 ~ 30 min 1 ~ 2 43 ~ 46 1 20 min 25 1 5 ~ 7 39 79. 49% 12. 82% 6 157 90. 44% 8. 92% 7 138 95. 7% 4. 3% 100% 8 2. 2 1980 1999 20 80 8 1988 1990 1999 3 8 1950 1999 1960 12 1960 12 1963 4 1980 7 1981 8 1981 10 1982 5 1986 6 + 1988 7 + 1990 4 1991 6 1993 4 + 1997 1 1998 7 1999 7 1 2 3 1960 12 1960 12 10

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 667 53. 22% 100% 24 3% ~ 16% 10 13 1980 330 1988 48 2. 3 2000 2011 10-9 9 2000 2011 2001 2007 2001 2 2008 2002 2008 2002 2008 2003 2008 2003 2009 2003 2009 2003 2009 2003 2009 2004 2010 2 2005 2010 2006 2011 2007 2011 2007 2011 2. 3. 1 9 80% 10 95. 4 ± 6. 4 % 11

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 10 % /% /% 46 69. 6 98. 1 1998 30 6. 67 100. 0 2001 128 70. 3 97. 7 2001 85 96. 5 2003 103 56. 3 100. 0 2007 30 33. 3 2007 478 10. 7 90. 8 2009 135 51. 1 98. 5 2009 463 14. 3 79. 7 2010 92 64. 1 100. 0 2008 26 92. 3 2011 1 2 1 10 128 500 ~ 1 000 g 300 ~ 1 000 ml 250 ~ 500 ml 0. 5 cm 30 ~ 40 min 1 10 1 10 30 min 1 128 6 90 35 3 97. 7% 11 85 42 ~ 45 3 cm 30 min 3 1 40 15 d 1 2 d 11 12 1998 46 46 16 9 8 8 5 30 g 30 g 30 g 5 g 12 g 6 g 40% 12

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 2 cm 1 ~ 2 h 7 ~ 10 d 1 32 13 1 98. 1% 11 n = 85 n = 40 / 10. 7 ± 4. 1 4. 8 ± 2. 3 ** 10. 6 ± 4. 1 7. 1 ± 4. 3 / 6. 8 ± 2. 4 2. 6 ± 1. 6 ** 7. 1 ± 2. 2 4. 1 ± 2. 0 / 7. 2 ± 1. 9 2. 9 ± 1. 7 ** 7. 5 ± 1. 8 3. 8 ± 1. 9 /min 86. 5 ± 39. 7 33. 9 ± 11. 6 ** 89. 6 ± 38. 4 49. 4 ± 24. 3 /kpa 10. 5 ± 5. 0 15. 1 ± 7. 4 ** 9. 7 ± 4. 5 13. 1 ± 4. 2 15 m /s 25. 1 ± 5. 3 17. 8 ± 2. 6 ** 24. 7 ± 5. 5 19. 8 ± 3. 1 / mm h -1 47. 6 ± 16. 2 28. 7 ± 13. 2 ** 50. 7 ± 16. 4 33. 8 ± 10. 5 /d 8. 0 ± 2. 2 9. 3 ± 2. 5 /d 11. 0 ± 2. 7 12. 2 ± 3. 0 1 2 **P < 0. 01 2 13 46 ~ 52 39 30 1 15 min 24 1 30 2 20 8 100% 0 8 21 97% P < 0. 01 14 3 m 20 6 42 ~ 43 25 min 1 10 ~ 15 min / 1 /d15 1 1 79. 65% 62. 50% 12 12 n = 30 13 n = 30 n = 231 14 n = 232 n 2 6. 67 0 0. 00 33 14. 28 9 3. 88 n 20 66. 67 8 26. 67 85 36. 80 53 22. 84 n 8 26. 67 21 70. 00 66 28. 57 83 35. 78 n 0 0. 00 1 3. 33 47 20. 35 87 37. 50 /% 100. 00 97. 67 79. 65 62. 50 13 48 d 14 1 15 d % 13

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 15 40 ~ 43 3 cm 13. 56 MHz 200 W 22 m 15 min 1 15 d 1 100% 67% ~ 99% 34% ~ 66% 33% 56. 3% 36. 9% 20 ~ 26 d 13 13 n = 103 n = 103 2. 68 ± 0. 49 2. 27 ± 0. 59 0. 28 ± 0. 25 0. 29 ± 0. 69 1. 54 ± 0. 69 1. 81 ± 0. 59 0. 32 ± 0. 49 0. 65 ± 0. 60 1. 18 ± 0. 84 1. 41 ± 0. 86 0. 18 ± 0. 05 0. 38 ± 0. 69 5. 36 ± 1. 46 5. 65 ± 1. 54 P < 0. 05 0. 89 ± 1. 63 1. 29 ± 1. 21 3 16 38 ~ 42 26 15 min 1 20 1 3 ~ 5 d 2 ~ 3 5 14 92. 3% 14 n = 26 n = 26 /% P 14. 08 ± 2. 04 6. 31 ± 2. 11 55. 2 < 0. 01 5. 27 ± 0. 96 2. 31 ± 0. 74 56. 2 < 0. 01 5. 15 ± 0. 43 2. 23 ± 0. 51 56. 7 < 0. 01 5. 50 ± 0. 95 3. 08 ± 0. 74 44. 0 < 0. 01 4. 30 ± 1. 10 2. 00 ± 0. 57 53. 8 < 0. 01 4 17 83 92 72 90 40. 5 ~ 41. 5 15 ~ 20 min 1 38 ~ 40 2 14

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 20 ~ 30 min 20 ~ 40 V 1 20 min 15 d 64. 1% 100. 0% 45. 6% 90. 0% P < 0. 05 18 30 46 ~ 52 1 15 min 24 1 8 0 0 20 5 19 478 1 11 00 16 00 2 h 7 d 1 6 15 8 15 40 3 10. 66% 80. 10% 15 15 182 16 152 14 179 21 140 18 76 10 58 8 31 2 24 1 8 2 5 1 2 0 2 0 478 100. 00 51 10. 66 363 80. 10 44 9. 20 6 20 2. 3. 2 1 2 21 30 48 ± 2 1 20 min 49 ± 1 1 20 min 24 1 2 h P < 0. 01 P < 0. 01 P < 0. 05 P < 0. 01 16 P < 0. 05 2 15

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 16 mmol /L n = 30 n = 30 11. 58 ± 3. 60 12. 70 ± 5. 30 7. 07 ± 2. 90 ** 7. 60 ± 0. 80 ** 2 h 17. 38 ± 5. 07 15. 40 ± 4. 80 12. 38 ± 2. 32 ** 10. 80 ± 1. 60 ** 5. 45 ± 0. 72 5. 54 ± 0. 79 4. 89 ± 0. 69 ** 4. 42 ± 0. 58 ** 1. 66 ± 0. 63 1. 62 ± 0. 21 1. 22 ± 0. 48 ** 1. 12 ± 0. 25 ** 3. 17 ± 0. 53 3. 24 ± 0. 54 2. 87 ± 0. 88 * 2. 91 ± 0. 82 * 1. 38 ± 0. 39 1. 37 ± 0. 41 1. 74 ± 0. 63 ** 1. 69 ± 0. 49 ** 1 1 24 d 2 * P < 0. 05 **P < 0. 01 22 64 2 40 1 20 min 10 min 4 1 3 P < 0. 01 P < 0. 05 17 17 n = 32 n = 32 / mmol L -1 2 h / mmol L -1 w /% / kg m 2 8. 3 ± 2. 0 8. 7 ± 2. 1 6. 5 ± 2. 2 ** 7. 6 ± 2. 1 * 12. 2 ± 3. 3 12. 8 ± 3. 2 9. 4 ± 2. 9 ** 10. 9 ± 3. 0 * 8. 0 ± 1. 3 8. 2 ± 1. 4 6. 8 ± 1. 2 ** 7. 5 ± 1. 2 26. 0 ± 3. 8 25. 9 ± 4. 1 23. 4 ± 3. 6 ** 25. 6 ± 3. 7 1 3 12 2 * P < 0. 05 **P < 0. 01 2 23 90 2. 5 kg 5% 16

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 42 ~ 45 20 min 14 d 1 18 18 n = 90 n = 90 mmol /L 10. 77 ± 2. 56 5. 94 ± 1. 75 mmol /L 6. 13 ± 2. 01 3. 25 ± 1. 43 mmol /L 3. 47 ± 0. 66 1. 52 ± 0. 78 n % 36 40. 00 7 7. 78 n % 24 26. 67 5 5. 56 n % 18 20. 00 4 4. 44 n % 12 13. 33 2 2. 22 n % 25 27. 78 6 6. 67 n % 45 50. 00 10 11. 11 n % 20 22. 11 74 82. 22 24-25 n = 21 n = 16 B 12 4 P < 0. 05 19 1 24 d P < 0. 01 P < 0. 01 P < 0. 05 P < 0. 01 P < 0. 05 19 m /s n = 21 B 12 n = 16 33. 4 ± 4. 4 33. 2 ± 4. 5 37. 4 ± 4. 6 * 34. 3 ± 4. 5 37. 3 ± 4. 5 37. 5 ± 4. 9 41. 8 ± 6. 0 * 38. 0 ± 5. 1 32. 3 ± 6. 5 31. 8 ± 6. 0 36. 2 ± 6. 4 * 33. 3 ± 5. 0 1 * P < 0. 05 2 P < 0. 05 26 25 35 ~ 80 30 min 10 30 17

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 2. 3. 3 43% 92% 20 38. 5% 90. 2% 49. 6% 94. 8% 20 /% /% + + 60 46. 7 100. 0 2003 + + 60 26. 7 98. 3 + + 60 50. 0 86. 7 2010 + 60 26. 7 71. 7 + 40 42. 5 92. 5 2003 + + 50 58. 0 98. 0 2008 + 50 24. 0 88. 0 + + 186 66. 7 98. 4 2006 1 2 38. 5 ± 11. 1 % 90. 2 ± 11. 3 % 3 49. 6 ± 22. 6 % 94. 8 ± 5. 9 % 1 27 60 38 ± 1 1 15 min 48 ~ 52 1 15 min15 1 2 ~ 3 d 28 17 100. 0% 98. 3% 28 60 60 40 ~ 41 15 ~ 30 min 30 min 5 ~ 25 kg 10 ~ 30 min 1 1 30 86. 7% 16 71. 7% 29 40 0 ~ 30 10 ~ 18 kg 10 ~ 15 min 1 45 1 20 min20 1 17 20 3 92. 5% 2 30 B A 50 40 ~ 44 1 15 min A B 18

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 58. 0% 24. 0% 98. 0% 88. 0% 31 186 40. 5 ~ 41. 5 1 15 ~ 20 min 20 d 1 180 1 66. 7% 46. 7% 98. 4% 88. 3% P < 0. 05 2. 3. 4 32 130 55 ~ 60 42 ~ 43 3 cm 1 30 min 45 42 ~ 43 1 ~ 10 130 96 31 4 96. 9% 2. 3. 5 33 34 21 n = 226 n = 225 42 ~ 43 1 n 128 56. 64 21 9. 33 25 min 7 1 14 d n 47 20. 80 32 14. 22 n 46 20. 35 40 17. 78 6 n 5 2. 21 132 58. 66 97. 8% /% 97. 78 41. 33 41. 3% 21 1 + 99. 1% 2 66. 4% 35 135 33 20 d 69 33 31 98. 5% 134 31 32 55 88. 1% 2. 3. 6 90 1990 3 667 53. 2% 100. 0% 36 38 36 2 34 4 50 ~ 55 1 30 min 30 24 10 4 19

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 63. 2% 100. 0% 129. 8 90 ~ 180 d 115. 6 90 ~ 148 d 98. 2 90 ~ 124 d 35. 7% 37 Fe Mn Ba Zn Co Mo 3 ~ 4 20 ~ 30 min 7 d 1 300 296 90 38 174 156 14 4 144 30 1 cm 1 h 30 min 40 ~ 60 min 3 ~ 6 300 ~ 500 ml10 d 1 5 7 30 17. 24% 78 44. 83% 62 33. 65% 4 2. 30% 97. 7% 3 1 2 3 4 3. 1 3. 1. 1 1 2 2. 0 ~ 2. 4 kj 3 0. 002 mm 4 20 5

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 4. 2 kj 6 7 8 3. 1. 2 1 2 3 100 22 22 % 20 ~ 50 2 ~ 9 50 ~ 60 2 5 90 ~ 97 10 20 ~ 30 70 39 40-42 3. 2 3. 2. 1 34 ~ 39 40 3. 2. 2-21

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 3. 2. 3 10 3. 2. 4 3. 2. 5 α β γ 3. 3 3. 3. 1 43 15 1 20 min 28 d SOD MDA SOD 23 23 SOD MDA SOD MDA SOD MDA n = 12 193 ± 26 6. 2 ± 2. 0 ** 215 ± 72 ** 3. 6 ± 2. 3 n = 11 187 ± 27 4. 2 ± 2. 1 141 ± 69 2. 8 ± 2. 0 1 SOD Nu /ml MDA mmol /L 2 ** P < 0. 01 44 SD DOX DOX Ca 2 + ROS24 22

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 24 Ca 2 + ROS Ca 2 + ROS 520 ± 62 1 236 ± 98 DOX 1 870 ± 132 * 3 450 ± 230 * /DOX 587 ± 42 1 200 ± 96 * P < 0. 05 P > 0. 05 3. 3. 2 45 AIA Wistar AIA 3 19 d 30 TNF - α AIA TNF - α 25 BELLOMELT 25 1997 2000 TNF - α ρ TNF - α IL -1 IGF - 1 PGE 2 74. 54 ± 32. 27 * 102. 77 ± 36. 93 101. 92 ± 22. 42 TNF - α P < 0. 01 AIA TNF - α 1 13 μg /L 2 * P < 0. 05 3 3. 3. 3 m RNA 45 AIA MMP -1 m RNA ICAM -1 m 26 MMPs ICAM -1 MMP -1 ICAM -1 MMP -1 ICAM -1 26 AIA MMP ICAM MMP -1 m RNA ICAM -1 m RNA MMP -1 m RNA ICAM -1 m RNA 1. 83 ± 0. 69 ** 2. 08 ± 0. 95 1. 69 ± 0. 95 ** 1. 46 ± 0. 66 ** 2. 77 ± 1. 09 2. 15 ± 1. 07 2. 62 ± 0. 87 1. 92 ± 1. 04 ** 3. 38 ± 0. 87 2. 92 ± 1. 04 2. 92 ± 1. 04 2. 77 ± 0. 93 1 13 2 ** P < 0. 01 3 P < 0. 05 P < 0. 01 23

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 3. 3. 4 23 27 21 1 24 d 200 /s 5 /s 28 27 / mpa s / mm h -1 n = 90 14. 68 ± 3. 21 6. 34 ± 2. 15 3. 92 ± 1. 30 9. 43 ± 1. 67 n = 90 11. 07 ± 2. 18 * 4. 31 ± 0. 92 * 1. 53 ± 0. 42 * 8. 94 ± 1. 75 1 * P < 0. 05 2 200 /s 5 /s 28 n = 60 n = 60 / mpa s 6. 14 ± 1. 67 5. 28 ± 1. 25 / mpa s 7. 14 ± 1. 67 6. 28 ± 1. 15 /% 44. 0 ± 5. 0 39. 0 ± 3. 0 / mm h -1 28. 40 ± 13. 48 22. 50 ± 9. 89 9. 13 ± 1. 49 8. 36 ± 1. 27 ρ / g L -1 4. 50 ± 0. 90 3. 81 ± 0. 60 1 P < 0. 05 2 200 /s 5 /s 3. 3. 5 21 22 23 2 2 h 16 17 18 16 17 3. 3. 6 46 ET CGRP ET CGRP ET CGRP ET CGRP ET CGRP 29 ET CGRP 24

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 29 ET CGRP μg /L ρ ET ρ CGRP 3. 72 ± 1. 25 89. 47 ± 4. 12 17. 66 ± 4. 82 ** 49. 41 ± 2. 78 ** 4. 65 ± 1. 38 71. 30 ± 6. 52 16. 86 ± 4. 78 ** 48. 66 ± 3. 18 ** 1 12 2 ** P < 0. 01 3. 3. 7 23 30 30 Ⅰ Ⅱ Ⅲ n = 90 41 45. 56 30 33. 33 19 21. 11 n = 90 7 7. 78 14 15. 56 69 76. 67 1 Ⅰ Ⅱ Ⅲ 2 % 3 χ 2 P < 0. 05 24-25 1 4 31 31 m /s 24 25 + 33. 4 ± 4. 4 37. 4 ± 4. 6 * 32. 3 ± 6. 5 36. 2 ± 6. 4 * 37. 3 ± 4. 5 41. 8 ± 6. 0 * 34. 9 ± 4. 5 40. 1 ± 4. 3 ** 36. 8 ± 4. 2 41. 2 ± 4. 3 ** 1 24 n = 21 25 n = 40 2 * P < 0. 05 **P < 0. 01 3. 3. 8 32 R SH G CSF c R SH / μmol L -1 G CSF /% 137. 04 ± 5. 12 8. 33 123. 55 ± 7. 38 ** 75. 00 ** 40 139. 37 ± 4. 47 16. 66 121. 42 ± 7. 43 83. 33 20 1 12 **P < 0. 01 2 25

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 min 20 d G -CSF R -SH G - CSF R - SH 32 1. M. 2005 1-256. 2. M.. 1986 214-216. 3. M. 2003 28-41 330 434. 4. M. 1985 423-453. 5. M. 1963 33-38. 6. 39 J. 1960 12 45-47. 7. 157 J. 1960 12 48 47. 8. 138 J. 1963 3 18-19. 9. 97-98. J. 2011 39 2 10. 128 J. 2001 5 40-41. 11. 85 J. 2003 35 1 24-25. 12. 46 J. 1998 11 7 655. 13. J. 2001 11 1 54-55. 14. 62. J. 2010 12 1 15. J. 2007 16 2 72-73. 16. J. 2011 20 2 99-100. 17. J. 2008 10 5 369-370. 18. J. 2007 16 3 136-137. 19. J. 2009 2 25-26. 20. 97-98. J. 2011 39 2 21. J. 2005 27 2 110-112. 22. 2 J. 2008 6 1 5-6. 23. J. 2003 12 5 14-15. 26

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 24. J. 2003 12 1 7-8. 25. J. 2007 29 9 600-601. 26. J. 2003 11 5 33. 27. J. 2003 25 12 735. 28. J. 2010 27 3 263. 29. J. 2003 7 23 3272. 30.. J. 2008 3 4 18. 31. 2006 28 6 372. J. 32. 130 J. 2002 4 15-16. 33. J. 2008 51 3 137-138. 34. J. 2009 11 5 381-382. 35. J. 2009 11 5 386-387. 36. 38 J. 1992 14 1 75-78. 37. 300 J. 2002 23 8 32. 38. 174 J. 1997 6 1 77-78. 39. M. 2004 90-120. 40. J. 2006 4 2-3. 41. J. 2005 4 26-27. 42. J. 1997 6 3 3-4. 43. J. 2002 6 17 2542-2543. 44. J. 2002 9 1 24-26. 45. J. 2003 25 4 202-205. 46. J. 2002 11 3 8-9. 47. J. 2002 25 1 31-33 37. 27

2011 GUANGDONG WEILIANG YUANSU KEXUE 18 12 The Mud Therapy in China Cure QIN Junfa 1 LI Zengxi 2 LOU Manteng 2 1. Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China 2. Guangzhou Institute of trace Elements Guangzhou 510070 China Abstract In the past times the mud therapy was belong to the folk remedies. But now it has became a fashion of return to nature and a means of health care treatment. A review with 71 references is given on documentary clinical application mechanism exploration analysis of the components four parts including the development process of mud therapy and its science foundation in China. Key words China mud therapy thermal mineral mud hot spring trace elements radioactive radon 1994 CN44 1396 /T ISSN 1006 446X CA 15 10 120 E - mail gdwlyskx@ periodicals. net. cn www. lhzd. com 5628 100 58 1001 510070 3602017019200091333 28