[] [][] [][][] [][] [] [][] [] [][][] [][] [] []1% 0.003%0.005% 0.02 [] [] C [][] [][][] [][][]1%0.003%0.005% [][][] [][][ ][][][][]
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- 锭 瞿
- 7 years ago
- Views:
Transcription
1 (a) (b) (c) (d) (e) (f) (g) (h) (i) (j) (k) 1933
2 [] [][] [][][] [][] [] [][] [] [][][] [][] [] []1% 0.003%0.005% 0.02 [] [] C [][] [][][] [][][]1%0.003%0.005% [][][] [][][ ][][][][][] [] []201477[ ][] [] []S [](i) 144A(ii)S []
3 (1) [] i
4 (1) [] ii
5 (1) [] iii
6 ... i... iv I-1... II-1... III-1... IV-1... V-1... VI-1 iv
7 [] []40 [] %85.9%83.6% MENET IMS MENET IMS MENET 2013IMS , ,864.62, % 87.3%88.1%18.5% 1
8 , , MENET
9 % , ,135.92, % % %83.5%83.6% 3
10 4
11 (i) (ii) (iii)(iv) (v) (vi)(vii) (viii)(ix) (x)(xi)(xii) (xiii) (xiv)[] % 55.4%56.0% %43.4%43.0% 5
12 % % %... 1,774, ,135, ,515, (301,121) (17.0) (351,813) (16.5) (413,506) (16.4)... 1,473, ,784, ,101, , , , (980,111) (55.2) (1,209,717) (56.6) (1,378,061) (54.8)... (151,566) (8.5) (157,906) (7.4) (146,508) (5.8)... (147,307) (8.3) (145,522) (6.8) (206,669) (8.2)... (19,636) (1.1) (29,145) (1.4) (24,091) (1.0) , , , (34,902) (2.0) (79,862) (3.7) (55,224) (2.2) , , , ,041 1,088,568 1,652, , ,200 1,302, , , , ,404,387 1,583,807 1,897,695 6
13 % % % , , , , , , , , , , , , , , ,102, , , , , , , , , , , , , , , , , , , , , , , , , , , , ,774, ,135, ,515, (1) %
14 [] [][][][] [] [][][] S [][] [][][] [][] []%[] [][]% [] [][] [][] (1)... [] [] (2)(3)... [][] [][] (1) [][] (2) [][][][] [] (3) ,865,878324,339, ,932,992200,000,000 [][][] [ ][][] 8
15 [][][] [][][] [] 20%[] 20%[] 20%[] 20%[] 5%[] 5%[] 10%[] [] [][][] [][] [][][][] [][][][] 9
16 ,865, [][][] [][] []2014[] CDH FlowerCPE GreeneryBeyond Border 248,711, []CPE GreeneryCPE Palm Beach L.P.[]CPE Palm Beach L.P.Tropical Excellence []CDH FlowerCPE GreeneryBeyond BorderTropical Excellence[ ]%[]%[]%[]% 121 [] []% Ginkgo Trust Limited70% 10
17 Apex Group Holdings Apex Group Holdings Limited [] %15% 15% BCC Research Beyond Border Beyond Border Investment Limited Beyond BorderHarvest Hill Investment Ltd. AXA Direct Asia II, L.P. Beyond Border Beyond Border 11
18 BMI A
19 CDH Flower CDH Flower Limited CDH FlowerCDH Pharmaceutical Investments Limited CDH Flower CDH Flower 32 綠葉製藥集團有限公司 CPE Greenery CPE Greenery Ltd CPE Greenery CPEChina Fund, L.P.CPE Palm Beach L.P. CPE Greenery CPE Greenery 13
20 ,711, CDH FlowerCPE GreeneryBeyond Border [] [] eipo [] 14
21 [] [] [] [][] IMS IMS Health Incorporated [] 15
22 [][] [] [] [] Kang Hai Pharmaceutical Kang Hai Pharmaceutical Technology Development Limited [] 16
23 Ginkgo Trust Limited Shorea LBG Luye Hong Kong Luye Pharma Hong Kong Limited % 15%
24 MENET OECD [] 18
25 [] []30 [][] [][]15% [][] 144A S S A A 144A 19
26 [] 505(b)(2) 505(b)(2) [] Solid Success Solid Success Holdings Limited [] 20
27 Steward Cross Steward Cross Pte. Ltd % [] Tropical Excellence Tropical Excellence Infrastructure Pte. Ltd GIC Special Investments Pte. Ltd.Tropical ExcellenceCPE Greenery 1933 eipo [] 21
28 eipo [] % 10% 22
29 23
30 24
31 100 25
32
33 FDA 27
34 DNA G1S II 28
35 GMP GSP ACE FDA 29
36 DNA 30
37 31
38 II 32
39 DNARNA 33
40 PCT 34
41 35
42 36
43 II
44 38
45 39
46 %87.3%88.1% %60.0%60.4% %32.8%33.7% %55.4%56.0% %43.4%43.0% 40
47 % %20.6%22.8% % % %9.9%9.1% % %1.7%1.7% % 41
48 42
49
50 FDA 44
51 45
52 %13.5% %96.7% 46
53 10 47
54
55 49
56 %56.4%56.1% 50
57 51
58 52
59 53
60 %6.3%7.7% 54
61
62
63 15% 25% %25%
64 %
65 10 59
66 60
67
68 62
69 ,4404% 2,
70 100,
71
72 % 10% 50% 10%
73 25% % 10% 10% 10% 67
74 [ ] [][] [] [] [][] [][] [] [] 68
75 [][][][][] [][] [][] [] 69
76 [] [][] [] [][]% [] [] [] 70
77 [] 71
78 [] (a) 3.05 (b) (c) (d) (e) 9.09(b)
79 [] []% CPE GreeneryCPE Palm Beach L.P. CPE Coinvest Management Limited[] []% CPE Coinvest Management Limited Tropical ExcellenceCPE Palm Beach L.P. (i)(ii)cpe GreeneryTropical Excellence 9.09(b) (a) (b) (c) (d) CPE GreeneryCPEChina Fund, L.P.CPE Palm Beach L.P. Tropical ExcellenceCPE Greenery CPE Palm Beach L.P. CPE GreeneryTropical Excellence (i) (ii) 73
80 [] 74
81 [] 75
82 [] 76
83 [] 77
84 # W E
85 12 2 [] 52 16C 2 16A 38 15B []
86 []
87 7 A40 Conyers Dill & Pearman [] [] [] 81
88 Clarendon House 2 Church Street Hamilton HM 11 Bermuda D (FCISFCS) W
89 [] []
90 [] , , % %Economist Intelligence Unit EIU , , % EIU ,95639, % , ,6009.8% 100,000 80,000 60,000 40,000 20,000 31,597 71,246 64,407 58,155 52,924 47,262 40,282 34,878 35,296 30,196 23,956 26,323 52,348 47,498 43,078 39,349 78,400 85,825 57,394 62,600 80,000 60,000 40,000 20, EIU 84
91 EIU20081, , % 20133, , % EIU EIU % %127.1 EIU ,500 2,908 3,000 2,500 2,000 1,500 1, EIU OECDEspicom %
92 (%)... 2, ,980 9, ,238 4, ,739 4, ,107 4,942 (0.8) ,970 3,732 (1.5) ,769 5, , ,404 3,010 (3.0) ,058 7, OECDEspicomEIU OECDEspicom %12.0%17.9% (%) OECDEspicom EIU 20082, , % %20178,470 86
93 EIU ( ) ,4276, , % 0.02%
94 6.5%7.0% Business Monitor International 43(CNS) (ADHD)5%
95 (1/100,000) (1/100,000) Espicom %Espicom 20171, % Espicom
96 20136,986IMS %9.2% 75%2015 GMP % MENET % 90
97 2013 % % 18.0% % 6.2% % 18.1% % 19.2% % 17.7% % 22.3% % 20.6% % 21.4% % 17.0% % 17.1% % 17.4% MENET % HPV % 0.1% 0.2% % 0.1% 0.1% 91
98 % 80% % 1.4% 1.8% % 0.7% 1.0% % 2.6% 5.5% III 1. II 2. IIII 3.
99 (International Diabetes Federation) II 80% % % 0.8% 1.3% % 0.6% 1.1% % % 0.2% 0.2% % 0.4% 0.4% EIUMENET IMSBusiness Monitor InternationalEspicomBCC Research
100
101 GMP
102 GMP GMP GMP GMP I IIIII IV 96
103 5 I (1) (2)(3) (4) (5)(6) (1) (2)(3) (4) I 97
104 3 5 6 GSP
105 GSP GSP GSP
106
107
108 15%
109 %125%
110
111
112 , %
113 (1) (2) (3) (1) (2)(3)
114 %4.07%
115
116 %15% (1) (2) (3) (4)(5) 25% % 10% 110
117 % % %10% 25% 5% % 50% 111
118 (1) 5 (2) (3) (4) (5) 60%(6) (1)(2) (3)(4) (5) (6) 112
119 (4) 113
120 199468Yantai Bio-technology Co. Ltd. Yantai Bio-tech Yantai Bio-tech62.5% 37.5% % 114
121 2009 綠葉製藥集團有限公司 26.6% 69.6%
122 2009 Certificate of Manufacturing Facility SGS United Kingdom Ltd.ISO9001: Yantai Bio-tech62.5%37.5%Yantai Bio-tech 116
123 Yantai Bio-tech91.5% ,264, % % Yantai Luye Pharma Holdings Co. Ltd.Yantai Luye Pharma Holdings Co. Ltd. 43,590,000 Yantai Luye Pharma Holdings Co. Ltd %14%3%3% Solid Success %20071 Hui Tin Cho345.0Solid Success 117
124 Solid Success Solid SuccessSolid SuccessApex Group HoldingsKang Hai Pharmaceutical Apex Group HoldingsKang Hai Pharmaceutical Apex Group HoldingsKang Hai Pharmaceutical75% 75% Kang Hai PharmaceuticalApex Group Holdings75%21.4%3.6% Peking University Technology Development Department Peking University Weiming Biotechnology Group 30.4% 43%26.6% %19,871, Beijing Enterprises Biotech Limited Luye Hong KongPacific Target Holdings Limited26.6% 102,040, % Beijing Enterprises Biotech Limited 5,260, Luye Hong Kong69.6%
125 % 99.7%0.3% AsiaPharm Group Ltd % 6.61% 99.56%
126 248,711, %4.75% % 70% 15% (1) 0.01 (2) CDH FlowerCPE GreeneryBeyond Border % Hygeia Holdings Limited Hygeia Holdings Limited 120
127 12 105, % 7.37% %39.8%41.3% CDH FlowerCPE GreeneryBeyond Border ,711,
128 : 248,711, : ,183, ,527, : [][] [][ ]% : : 10% : LPH Group
129 : LPH Group 0.22 : (i) Hygeia Holdings Limited (ii) (iii) : LPH Group CompanyLPH Group : : LPH Group CompanyLPH GroupLPH Group 123
130 : [] 60% [] 40% 10% [ ] : 75% [] 60% [] 40% 124
131 []CPE Greenery []CPE Palm Beach L.P.CPE Coinvest Management Limited CPE Palm Beach L.P.CPE GreeneryCPE Coinvest Management LimitedCPE Greenery[] Tropical ExcellenceCPE Palm Beach L.P.CPE Coinvest Management LimitedTropical Excellence[] CPE GreeneryCPE Palm Beach L.P.CPE Greenery CPEChina Fund, L.P. CPE Greenery[] Tropical ExcellenceGIC Special Investments Pte. Ltd.GIC Special Investments Pte. Ltd. GIC Private LimitedGIC Private Limited []CDH FlowerCPE GreeneryBeyond BorderTropical Excellence[ ]%[]%[]%[]%Tropical Excellence []10% 8.08 HKEx-GL29-12HKEx-GL43-12HKEx-GL
132 CDH Flower CDH FlowerCDH Pharmaceutical Investments Limited CDH PIL CDH PILCDH Fund IV, L.P. CDH Fund IV CDH IV Holdings Company Limited CDH Fund IVCDH China Management Company Limited CDHCDH Fund IVCDH CPE Greenery CPE GreeneryCPEChina Fund, L.P. CPEChina CPE Palm Beach L.P. CPE Palm Beach CPEChinaCITIC PE Associates, L.P.CITIC PE Funds LimitedCPE Palm Beach CPE Coinvest Management LimitedCPEChina CPE Palm BeachCPEChina CPE Greenery 267,902,223CPE Palm Beach CPE Coinvest Management Limited CPE Palm BeachCPE GreeneryCPE GreeneryCPEChina Beyond Border Beyond BorderHarvest Hill Investment Ltd. HHI AXA Direct Asia II,L. P. AXA FundHHINew Horizon Capital III, L.P. NHCNHC New Horizon Capital Partners III Ltd. New Horizon New Horizon AXA Fund AXA FundAXA PE Asia Manager Limited AXA Fund 126
133 Nelumbo Investments Limited 70% Nelumbo Investments LimitedGinkgo Trust LimitedGinkgo Trust LimitedShorea LBG , % 2 127
134 Ginkgo Trust Limited (1) Nelumbo Investments Limited * 15% 70% 15% * * (2)(3) * * * Luye Hong Kong * * Yantai Luye Pharma Holdings Co. Ltd. * Luye Pharma Investments Pte. Ltd. * AsiaPharm Biotech Sdn. Bhd. ^ AsiaPharm Biotech Pte. Ltd. ^ 36.0% Steward Cross ^ (4) Solid Success * # SmartMedicine Sdn. Bhd. (5) Kang Hai Apex Group Holdings Pharmaceutical * * 3.6% 21.4% Shandong Luye Natural Drugs R&D Co. Ltd. # (6) (8) # 75.0% 69.6% Shandong Langhe Biotech Co. Ltd. Luye Biotech (Singapore) Pte. Ltd. A-Bio Pharma Pte. Ltd. (7) Nanjing Kanghai Phospholipid Biotech Technology Co. Ltd. # Shanghai Ge Lin Li Fu Business Consulting Co. Ltd. (9) ^ 0.3% 99.7% # Chengdu Bomai Technology Co. Ltd. 128
135 * # ^ (1) Ginkgo Trust LimitedShorea LBG Nelumbo Investments Limited (2) % (3) CDH FlowerCPE GreeneryBeyond Border0.01 (4) Steward CrossSiow Kwong ThyeMichael Tay Poh ChoonGrace Yip Yin May Ng Swee Pheng20%7%27%10% (5) SmartMedicine Sdn. Bhd (6) (7) A-Bio Pharma Pte. Ltd. (8) Beijing Beida Asset Management Co. Ltd.Beijing Beida Asset Management Co. Ltd. (9) Shanghai Ge Lin Li Fu Business Consulting Co. Ltd. 129
136 [] Ginkgo Trust Limited (1) Nelumbo Investments Limited * 15% 70% 15% * * * * CDH Flower CPE Greenery Beyond Border Tropical Excellence % % % % % % * Luye Hong Kong Luye Pharma Investments Pte. Ltd. * * * Yantai Luye Pharma Holdings Co. Ltd. * Asia Pharm Biotech Sdn. Bhd. ^ AsiaPharm Biotech Pte. Ltd. ^ 36.0% Steward Cross ^ Solid Success * # SmartMedicine Sdn. Bhd. Apex Group Holdings Kang Hai Pharmaceutical * * 3.6% 21.4% # # 75.0% 69.6% Shandong Luye Natural Drugs R&D Co. Ltd. Shandong Langhe Biotech Co. Ltd. Luye Biotech (Singapore) Pte. Ltd. A-Bio Pharma Pte. Ltd. Nanjing Kanghai Phospholipid Biotech Technology Co. Ltd. # Shanghai Ge Lin Li Fu Business Consulting Co. Ltd. ^ 0.3% 99.7% # Chengdu Bomai Technology Co. Ltd. 130
137 * # ^ (1) Ginkgo Trust LimitedShorea LBG Nelumbo Investments Limited (2) % (3) CDH FlowerCPE GreeneryBeyond Border0.01 (4) Steward CrossSiow Kwong ThyeMichael Tay Poh ChoonGrace Yip Yin May Ng Swee Pheng20%7%27%10% (5) SmartMedicine Sdn. Bhd (6) (7) A-Bio Pharma Pte. Ltd. (8) Beijing Beida Asset Management Co. Ltd.Beijing Beida Asset Management Co. Ltd. (9) Shanghai Ge Lin Li Fu Business Consulting Co. Ltd [] A
138 %85.9%83.6% MENET IMS MENET IMS MENET 2013IMS , ,864.62, % 87.3%88.1%18.5% , ,
139 MENET %
140 , ,135.92, % % %83.5%83.6% 2012 MENET %IMS , %44.1%43.8% 2012 MENET % IMS %29.5%28.7% 134
141 MENET %IMS %21.1%22.9% MENET % , ,864.62, %87.3% 88.1% IMS IMS % IMS IMS
142 IMS IMS %IMS % IMS IMS % II IMS IMS % IMS IMS % 136
143
144 IMS % 2015 IMS % 2016 IMS % IMS %2016 IMS %
145 IMS % 2017 II IMS % 2017 SNDRI IMS % 2018 II II IMS %
146 505(b)(2) , , , % 2, % 4, % 140
147 (i) (ii) (iii) (iv) % % % 141
148
149
150 144
151
152 %13.0% 146
153 % % % , , ,102, , , , , , , , , , ,774, ,135, ,515, % % % , , , , , , , , , , , , , , , , , , , , , ,577, ,864, ,215, , , , ,774, ,135, ,515, (1)
154 H ZL RU IDP IN IN EP H ZL US RU ID IN IN H EP H US JP ZL ZL Z H H H CN CN US CN H ) H H H H ZL
155 , %MENET %IMS %IMS %IMS % % %
156 % %20.1% 1999 IMS %IMS % % % 5.2% 150
157 , % % 16.0% % Lipascor
158 ,700 30%-33% LDL-C HDC C2008 IMS %IMS %IMS % , % % 2.6%
159 IMS %2013 IMS % , % %18.9% %IMS
160 II II 2013II IMS %IMS % GMP , % %53.5% ) 154
161 IMS %IMS % , % % 13.4% 155
162 501, , , %2, % 4, % 156
163 %30% 157
164 158
165 % 159
166 160
167 , %2, % 4, %
168 (89) (1) (2) (3) (4) (5)GSP 5% %16.1%15.9% %4.9%4.9%
169 9.6%11.0%10.8% GSP
170 0.8 1 GSPGSP GSP GSP 164
171 80%97%
172 %55.4%56.0% %43.4% 43.0% %20.6%22.8% 15% % %9.9%9.1%19% % % ,774.42,135.92, % ,473.31,784.12, % %83.5% 166
173 83.6%
174
175
176 BCC % FDA 170
177 6.5% %6.3%7.7% 171
178
179 (1) (1)
180 (1) (1)
181 (1) (1) (1) %40% NGT
182 IMS % IMS % 2016 Midas Pharma GmbHMidas Pharma GmbH 176
183 IMS % IMS %
184 2012PCT 2014PCT IMS % IMS %
185 1II IMS % 2017 (SNDRI) SNDRI IMS %
186 IV (DPP IV) II II 2029 IMS %
187 505(b)(2) 505(b)(2) GMP 181
188
189
190 , , GMPGMP (1) (%) (1) (%) (1) (%) (2)... 10,000 3,744 4, (3) 4, ,765 5, (4)... 10,000 44,000 5, ,000 5, ,000 5, (5)... 10,000 5, , ,000 1, (6)... 10,000 13,000 6, ,000 2, ,000 1, (7)... 10,000 80,000 52, ,000 56, ,000 77, (8)... 10, (9)... 10, , , (10) ,874 42, ,874 45, ,174 76, (1) 2608 (2) (3) % 184
191 (4) (5) (6) (7) (8) (9) (10) 58,43326, ,85043,
192 37,34830, ,15432, ,56622,
193 , , %96.7% 187
194 ; ,110[] [] 1993GMP 3 GMP GMP 188
195 GMP %45.3% 48.9%, %20.5%20.5% 5% 189
196 GMP GMPISO9001:2008 ISO14001:2004CNAS GMP 190
197 GMP GMP GMP GMP 191
198
199
200 ,801155, ,014132,850326,
201 21,4404% 2, , , % 15%5 32L 6(2) 342(1)(b)34(2) 195
202 (i)(ii) (iii) (iv) (i) (ii) (iii) 196
203 30 197
204 GSP GMP (CN ) (1) GMP (SD )
205 GMP (Lu L0736) GMP (Lu I0422) GMP (Lu J0484) (2) GMP (Lu M0798) GMP (BJ ) GMP (CN ) GMP (CN ) (3) (4) (5) 199
206 GMP (JS ) GMP (SC ) (6) GMP (CN ) (7) (1) (2) (3) (4) (5) (6) (7) GSP
207 ,2893, % % % , , , , , ,
208 GMP GMPGMP 202
209 GMPGSPISO9001:2008ISO14001: ,400,0004,600,000 2,000, Beijing Haidian Environmental Protection Bureau 42,
210 %85.9%83.6% ,577.61,864.62, %87.3%88.1%18.5% , %44.1%43.8% 17.4% % 29.5%28.7%8.5% %21.1%22.9%43.3% 204
211 ,754.22, , %99.1%99.2% , , , ,135.92, % % %83.5%83.6% 205
212 Espicom %20111, %20132, %8.5%43.3% Espicom % %6.3%7.7%
213 %55.4%56.0%
214 44.3%43.4%43.0% %20.6%22.8% 15% % %9.9%9.1%19% % % ,774.42,135.92, % , ,784.12, % %83.5%83.6% 208
215 (i) (ii) (iii) (iv)
216 % 15% 25% % %9.4% 210
217 % % 55.2%
218 1231 3% %14%15%
219
220
221
222 % % %... 1,774, ,135, ,515, (301,121) (17.0) (351,813) (16.5) (413,506) (16.4)... 1,473, ,784, ,101, , , , (980,111) (55.2) (1,209,717) (56.6) (1,378,061) (54.8).... (151,566) (8.5) (157,906) (7.4) (146,508) (5.8).... (147,307) (8.3) (145,522) (6.8) (206,669) (8.2).... (19,636) (1.1) (29,145) (1.4) (24,091) (1.0) , , , (34,902) (2.0) (79,862) (3.7) (55,224) (2.2) , , , , , , , , ,
223 % % % , , ,102, , , , , , , , , , ,774, ,135, ,515, % % % (%) (%) , , , , , , , , , , , , , , , , , , (1) 53.5 (1) , , , ,577, ,864, ,215, , , , ,774, ,135, ,515, (1)
224 (2) %85.9%83.6% %0.8%1.0% % % % , , , , , , , , , , , , , , , (1) , , , , , ,
225 (1) ,195, ,0001,757,000 23%26% % % % % , ,784.12, %83.5%83.6% 219
226 ,519 5,469 30, ,823 3,858 3, , , ,093 2,627 1, ,934 12,717 35,
227 % % % , , , , , , , , , , , , , , , , , , , ,209, ,378, % % % , , , , , , , , , , , , , , , , , , , , ,
228 %92.3%93.9% %6.3%7.7% ,789 34,425 26, (3,536) (5,796) (2,596) 19,253 28,629 23, ,285 28,662 23, ,636 29,145 24,091 36%Steward Cross2007AsiaPharm Biotech Pte. Ltd.Steward Cross Steward Cross Steward Cross Steward Cross , % , %
229 ,313 57,599 87, ,058 1, (38,436) 17,205 (33,441)... 34,902 79,862 55,
230 , % 20132, %20131, % % % % %
231 % % % % % % , %2013 2, %83.6% 225
232 20121, %20131, % % % % % % % % % % % 226
233 % % % % 6.5% % % % % % % %
234 , % 20122, , % 20121, % % % % % %
235 % % % % % % %
236 % , %20121, %83.5% %20121, % % % % % % % % % % % 230
237 % %6.5% % % % % % % %
238 , , , (608,112) (135,130) (554,376) ,963 91,517 87, (149,729) 109,289 (27,430) , , , , , , (i)77.3 (ii) 36.9Shandong Biological Technology Group (iii)15.9(iv) (i)92.0 (ii)
239 (i)58.9 (ii)36.4 (iii)35.9 (i)20.1 (ii) (i)163.8 (ii)29.8 (iii)
240
241 , , , , , , , , ,178 35,092 46,413 91, ,755 12, , , ,009 2, , , , , , , , ,041 1,070,743 1,651,552 2,015, , ,041 1,088,568 1,652,370 2,015, ,331 54,403 69,369 52, , , , , , , ,921 1,081, ,310 45,218 74,436 74, ,010 26,589 34,488 57, ,902 36, , ,200 1,302,983 1,537, , , , ,
242 ,
243 ,039 50,901 95, ,503 53,883 81, ,730 37,902 57, , , , (1) (1)
244 , , , , , , , , , (3,346) (2,073) (2,192) 455, , , (1) (1) , , , ,622 12,316 18, ,009 9,956 2, ,570 3, ,767 1,576 2, , , ,
245 , , , ,710 10,401 2, ,687 12,042 2, , , , ,331 50,049 56, ,354 13,103 34,331 54,403 69,
246 (1) (1) ,007 44,436 66, ,076 7,507 2, , ,331 54,403 69, []
247 ,081.91, %6.77% % % % 241
248 % []
249 % % % (1) (2) (3) (4) (5) (1) (2) (3) (4) (5) %11.1% 17.3% % 6.6%9.7% %123.1% 126.8% % 6.7%21.7%
250 % 17.6%22.0% %80%
251
252 4.29 [] [] (1) [] (2) (3)(4) (3)(4)(5)(6) [][] [].... [] [] [] [] [] [][] [].... [] [] [] [] [] (1) [] [] [] [] [] (2) [][][][] [] [] [][][] [] (3) ,865,878324,339, ,932,992200,000,000 [][][][ ][][] 246
253 (4) (5) [] [] (6) [] ,865,
254 20051,932, %15%15% , Steward Cross36% Steward Cross AsiaPharm (Singapore) Pte. Ltd , Shandong Biological Technology group
255 [][][] []
256 [] [ ]% Ginkgo Trust Limited 70% 15% %10% 70%15%
257 2004 [] %17%8% %85.9%83.6% 251
258
259 GSPGMP ,
260 254
261 [] % (i) 30%(ii) 255
262 256
263 A14A ,863, , ,863, %15%15% 257
264 %5%14A14A
265 [] 10,000,000, ,000, ,831,908 8,816,638 []% 2,212,701,935 44,254,039 []% [] [] [] []% [] [] 100% [] [] 259
266 (i)(ii)(iii) (iv)(v) 2. (c) 2. (d) [] []20% A
267 [] []10% A. 5. A
268 [] 262
269 [] 263
270 [] 264
271 [] 265
272 [] XV 23 10%.... [] []% (2)... [] []% (2)... [] []% (2)... [] []% Nelumbo Investments Limited (3)... [] []% Ginkgo Trust Limited (3)... [] []% Shorea LBG (3)... [] []% (3)... [] []% CPE Greenery... [] []% CITIC PE Funds Limited (4)... [] []% CDH Flower... [] []% CDH IV Holdings Company Limited (5)... [] []% Beyond Border... [] []% New Horizon Capital Partners III Ltd. (6)... [] []% 266
273 Tropical Excellence.... [] []% (7)... [] []% (1) (2) [] (3) Nelumbo Investments Limited70%Nelumbo Investments LimitedGinkgo Trust Limited Ginkgo Trust LimitedShorea LBG Ginkgo Trust Limited (4) CPE Palm BeachCPE Greenery CPE GreeneryCPEChinaCPEChinaCITIC PE Associates, L.P.CITIC PE Funds Limited (5) CDH FlowerCDH PILCDH PILCDH Fund IVCDH IV Holdings Company LimitedCDH Fund IV (6) Beyond BorderHHI81.82%HHINHCNHCNew Horizon Capital Partners III Ltd. (7) Tropical ExcellenceGIC (Ventures) Pte. Ltd.GIC (Ventures) Pte. Ltd. 2(1) [ ]XV23 10% 267
274
275 AsiaPharm Biotech Pte. Ltd.Luye Biotech (Singapore) Pte. Ltd. A-Bio Pharma Pte. Ltd
276 New Asia Partners Investment Holdings Limited Luye Hong KongSolid SuccessApex Group Holdings
277 B EMBA
278 Yancoal Australia Ltd. YAL
279 SVA Emerging Markets Partnership (Hong Kong) Limited 273
280 * * NTES* *
281
282 XV C.1.(a) 13.51(2) DDI Asia/Pacific International Ltd LLY (Schwarz Pharma AG)
283 KEDGE 22723D
284 300, ,000360,000300,
285 (i) (ii) (iii) A.19 3A.23 (a) (b) (c) [] (d)
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289 [] [][][][] (i)[] (ii) [][] [] [] [] 283
290 [] 284
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293 (A) 10.08[]10.08 (B) [] 287
294 [] (A) [] 288
295 [] (B) [] 289
296 [] (C) [] [] 290
297 [] [] [][] [][] [] []30 [][][][] 15%[][]1%0.003% 0.005%[] 291
298 [] [] [] []CITICPE Holdings LimitedCPEChina CPEChina5%CPEChina 3A.07 CITICPE Holdings LimitedCPEChina CPEChina5%3A.07 CPEChina [] 292
299 [] 293
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325 [] 319
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337 II. 1. 綠葉製藥集團有限公司 Clarendon House, 2 Church Street, Hamilton HM 11, Bermuda 137 Telok Ayer Street, #05-05, Singapore (a) AsiaPharm Biotech Pte. Ltd. ABPL(b) Luye Pharma Investments Pte. Ltd. Luye Pharma Investments(c) Luye Pharma Hong Kong Limited Luye Hong Kong Pacific Target Holdings Limited) (d) Solid Success Holdings Ltd. Solid Success(a) Kanghai Pharmaceutical Technology Development Limited Kang Hai(d) Apex Group Holding Limited Apex(d) A-Bio Pharma Pte. Ltd. A-Bio(b) Luye Biotech Pte. Ltd. Luye Biotech(b) % % , I-12
338 AsiaPharm Biotech Sdn. Bhd. AsiaPharm Biotech(m) (e) (f) Shandong Langhe Biotechnology Ltd. Shandong Langhe(f) Shandong Luye Natural Drug Research and Development Luye R&D(f) (g) (h) (i) Nanjing Kanghai Phospholipid Biological Technology Co., Ltd. Nanjing Kanghai Phospholipid(i) Shanghai Ge Lin Li Fu Consulting Co., Ltd. Shanghai Ge Lin(j) (k) Chengdu Bomai Technology Co., Ltd. Chengdu Bomai(l) Yantai Luye Pharma Holdings Co., Ltd. Yantai Luye % % 100, I-13
339 (a) (b) (c) (d) (e) (f) (g) (h) (i) (j) (k) (l) (m) 50ABPLA-Bio Luye Biotech 50Luye Pharma InvestmentsStephen Koh & Co Luye Hong KongKang HaiAPEX Tony Kam & co. Luye R&DShangdong Langhe Nanjing Kanghai Phospholipid Shanghai Ge Lin Chengdu Bomai 1965 AsiaPharm BiotechEMC&Associates I-14
340 (i) (ii)(iii)(i) (ii)(iii) I-15
341 (a) (b) (c) 5 20% 5 39 I-16
342 I-17
343 (a) (b) (c) (d) I-18
344 I-19
345 (a)(b) I-20
346 (a) (b) I-21
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348 5 I-23
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SinoMedia Holding Limited 139,400,000 13,940,000 125,460,000 3.48 1%0.004% 0.005% 0.0003125 623 3238D 3.482.63 3.481% 0.004%0.005%3.48 144A S (1) (2).......................... www.eipo.com.hk eipo (3).....
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ASIA ORIENT HOLDINGS LIMITED * 214 140,000,000 B 4% * ... 1... 4... 5... 6... 7... 8... 9... 10... 10... 11... 11... 12 40.98% Asia Standard Capital Asia Standard International Capital Limited XV Asia
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INTERNATIONAL ELITE LTD. 228,000,000 1.36 1% 0.004% 0.005% 0.01 8313 32342C (www.hkgem.com) i www.hkgem.com www.iel.hk........................................................................................................................................
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KWAN ON HOLDINGS LIMITED (a) (b) (c) (d) (e) (f) (g) (h) (i) (j) 1933 (k) KWAN ON HOLDINGS KWAN ON HOLDINGS LIMITED [ ] [] [][] [] [] [] 1% 0.0027% 0.005% [] [] [ ] 32 342C [ ] [ ] i [ ] ii [ ] http://www.kwanonconstruction.com............................................................................................................................................................
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Facebook ios App Store Android ios ios King & Slave Android (Sequoia Capital) 1) A 2) 98% 88.7% 2% 1.9% Ohm Ammaramorn Ammaramorn 9.4% 3) 4) BVI BVI BVI 9,999 BVI BVI BVI 50% 59,055,563 29,527,782 50%
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2015 DTXS SILK ROAD INVESTMENT HOLDINGS COMPANY LIMITED ( UDL HOLDINGS LIMITED ) ( ) (620) 目 錄 2 3 6 9 13 21 28 30 31 32 34 35 37 114 大 唐 西 市 絲 路 投 資 控 股 有 限 公 司 年 報 2015 公 司 資 料 2 Jean-Guy Carrier 頴 Crawford
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中國無線科技有限公司
China Wireless Technologies Limited 2004 2 3 4 6 12 15 26 27 28 29 30 32 33 1 Century Yard, Cricket Square Hutchins Drive P.O. Box 2681GT George Town Grand Cayman, the Cayman Islands British West Indies
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Dragon Crown Group Holdings Limited 275,000,000 27,500,000 247,500,000 1.40 1% 0.003%0.005% 0.10 935 32 342C 2011 6 2 2011 6 3 1.40 1.01.40 1% 0.003% 0.005% 1.4 1.01.40 www.dragoncrown.comwww.hkexnews.hk
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Breakthrough 2011 HAINAN MEILAN INTERNATIONAL AIRPORT COMPANY LIMITED : 0357 2 2 3 5 8 10 17 27 39 44 55 56 58 60 61 63 64 65 H Skytrax Skytrax ASQ 2 Hainan Meilan International Airport Company Limited
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2 5 6 14 16 18 22 29 31 32 33 34 35 79 80 04 01 Hong Kong Resources Holdings GroupJUSCO JUSCO 05 02 03 06 05 04 03 06 2010 02 01 2 07 24,000 12 11 10 09 08 10 11 500 12 08 Dorian Ho WAVE 09 07 100 3 4
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2 3 4 6 13 16 22 31 33 34 35 37 38 40 124 二 零 一 五 年 年 報 2 公 司 資 料 18 66 http://www.bdhk.com.hk 154 公 司 183 22 3 北 京 發 展 ( 香 港 ) 有 限 公 司 公 司 架 構 二 零 一 六 年 三 月 三 十 一 日 北 京 有 限 公 司 # 100% IDATA FINANCE TRADING
HUAXI HOLDINGS COMPANY LIMITED ( ) : 1689 2016 2 3 5 9 11 19 26 28 29 30 32 33 34 77 183 1906 07 Clifton House, P. O. Box 1350 Grand Cayman, KY1-1108 Cayman Islands Appleby Trust (Cayman) Ltd. Clifton
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01 02 03 06 07 25 41 43 44 45 47 48 50 52 135 136 Clarendon House, 2 Church Street Hamilton HM11, Bermuda Appleby Management (Bermuda) Ltd. Canon s Court, 22 Victoria Street, Hamilton HM12, Bermuda 183
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重 要 文 件 倘 閣 下 對 本 文 件 有 任 何 疑 問, 應 徵 詢 獨 立 專 業 意 見 RECRUIT HOLDINGS LIMITED 才 庫 媒 體 集 團 有 限 公 司 * ( 於 百 慕 達 繼 續 經 營 的 有 限 公 司 ) 全 部 已 發 行 股 本 以 介 紹 上 市 方 式 在 香 港 聯 合 交 易 所 有 限 公 司 主 板 上 市 主 板 股 份 代 號 :550
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前稱金天醫藥集團股份有限公司 於開曼群島註冊成立之有限公司 股份代號 2211 Annual Report 2015 年 度 報 告 UNIVERSAL HEALTH INTERNATIONAL GROUP HOLDING LIMITED 大健康國際集團控股有限公司 UNIVERSAL HEALTH INTERNATIONAL GROUP HOLDING LIMITED 大 健 康 國 際 集 團