Pa Shun Pharmaceutical International Holdings Limited 250,000, ,000,000 25,000, % % 0.005% C

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1 Pa Shun Pharmaceutical International Holdings Limited

2 Pa Shun Pharmaceutical International Holdings Limited 250,000, ,000,000 25,000, % % 0.005% C % %0.005% S

3 i

4 (1) (2) III (3) (4) (5) (6) (i)(ii) (7) 1,000, (8) ii

5 i iii

6 I II III IV V 1 iv

7 (i)(ii) (i)(ii) (iii) % % 0.05% 0.05% 1

8 (i) (ii) (iii) (iv)(v) (vi) (i) (ii) (iii) (iv) (v) 2

9 (i) (ii) (i) (ii)v-drug V-drug V-drugChubu Yakuhin Co., Ltd % A B A B 26.20% 3

10 , , , (582,575) (643,924) (665,126) , , , ,379 14,612 20, (710) (33,380) (35,990) (36,468) (25,137) (25,779) (46,729) , , , (3,453) (5,855) (9,013) (4,714) (51,881) (16,134) (33,236) ,418 81,312 71, (17,110) (18,243) (25,740) ,308 63,069 46, ,409 63,070 45, (101) (1) 185 (1) (1) (2) ,189 79,203 79,365 4

11 (1) (2) , , , , , , , , , ,591 48, , , , , , , , (42,242) 92,225 48, (2,698) (105,599) (16,294). 34,067 39,935 (30,933) (10,873) 26,561 1, ,120 39,227 65, (20) (413) ,227 65,375 67,059 5

12 % 18.9% 21.5% % 7.9% 5.4% % 45.0% 25.5% % 9.2% 6.5% % 53.2% 27.6% % ,525 74, % 695,860 89, % 707,053 98, % ,831 3, % 17,626 5, % 29,352 9, % ,755 52, % 80,863 55, % 110,788 73, % , , , , , ,067 6

13 ,165 61, % 703,245 79, % 713,577 90, % ,831 2, % 17,626 5, % 29,352 9, % ,036 68, % 105,374 66, % 132,924 82, % , , , , , , , , , , , , , , , , , ,

14 (i) (ii) (i) (ii) (A) (B)

15 (i) (ii) (i)(ii) % 2.1% % %

16 (i) (ii) % % % %

17 46.6% % 11.9 (i) (ii)(iii)(iv) (1) ,000 1,400 (2) (1) 1,000,000,000 (2) 1,000,000,000 11

18 Li Ho Tan Cheung Chi Mang Fast Sino Holdings Limited 47% 50% 3% A V-drug V-drugB 12

19 ,000,

20 %

21 622 Pa Shun Pharmaceutical International Holdings Ltd %

22 % 90% 10% 16

23 Cheung Chi Mang100% A 25,000,000 17

24 ,000, ,000,000 18

25 Jumbo Success Jumbo Success Holdings Limited Li Ho Tan Jumbo Success

26 ,500,000 15% % 20

27 A B S S

28 A A A (2015) A A A 102,912 A 8,000,000 A A B 2014 V-drug Jumbo Success (1) V-drug 2,000 (2) 22

29 B (2015) V-drug Jumbo Success B V-drug B V-drug 40,000 B 5,000,000 B B V-drug Jumbo Success

30 ,500,

31 V-drug V-drug Hong Kong Co., Limited Chubu Yakuhin Co., Ltd.Chubu Yakuhin Co., Ltd. Valor Co., Ltd. V-drug V-drug % 25% 20% % 25

32 * * 26

33 HPV DNA HPV HPV 27

34 28

35 (1) (2) (3) (4) (5) (6) (7) (8) 29

36 (a) 3.05 (b) (a) (b) (c) (c) 3A.19 (d) 30

37 (e)

38 (i) (ii) (iii) % 87.6% 83.5% 32

39 28.7% 38.2% 43.6% % 8.5% 10.4%

40 (i) (ii) (A) (B) %

41 , % 35

42 (i) (ii)(iii) (iv) (v) 36

43

44 % 74.1% 74.3% 38

45 % 90.5% 92.0% % 12.8% 15.2% 51.6% 43.8% 45.3% 39

46 % 51.6% 43.8% 45.3% 10,

47 (i) (ii)(iii) ,000 15%

48 42

49 43

50 44

51 25 45

52

53

54 48.8% 48

55 50, (i) (ii) 49

56

57 ,500 (i) (ii) (iii) (iv)(v) 51

58 (i) (ii) 52

59 % 25% 25% % 53

60 25% 5% % 54

61 % 55

62 10% % 50% 56

63 1,000,000, % 57

64 58

65 59

66

67 Codan Trust Company (Cayman) Limited 61

68 37,500,000 62

69 Li Ho Tan F 63

70 A

71 Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY Cayman Islands

72 Cricket Square, Hutchins Drive P.O. Box 2681 Grand Cayman KY Cayman Islands B C CPA California Board of Accountancy, CFA B HKICPA, ACCA B 29 66

73 58 39 Codan Trust Company (Cayman) Limited Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY Cayman Islands

74 477,000 (i) (ii) 68

75 2008 4, , % % , , % % 1, ,500 1, , , ,

76 , , % , , % ,618 12, % 11.5% 45,000 40,000 35,000 30,000 25,000 20,000 15,000 10,000 5,000 4,761 15,781 5,153 17, % % 5,919 19,109 6,977 21, % % 26,955 24,565 7,919 8,896 12,332 34, (1) (2) , , % % 18.0%

77 5.4% % , % % 6.8% 18.9% % % 1, % % 1,189 1, , (i) (ii)(iii)

78 % % 50% % , , % 20163, % %

79 2013 7,000 4,535 1, (i)(ii) (iii) 73

80 (i) (ii) OEM , , % ,707 2, % % 1, ,500 1, , , ,

81 % % 27.20% 25% 25.32% 24.48% 24.35% 20% 15% 10% 5% 12.50% 18.75% 7.90% 7.55% 21.49% 19.84% 19.96% 17.26% 16.28% 20.44% 16.98% 13.45% 13.06% 18.77% 17.10% 9.58% 9.48% 9.75% 17.20% 13.01% 9.00% 8.63% 8.95% 12.54% 11.83% 6.47% 8.15% 7.94% 12.00% 11.13% 6.62% 12.67% 9.84% 7.64% 7.95% 6.33% 0% % % 75

82 % % (i) 2009 (ii) (i) (ii)65 76

83 2,500 2,000 1,545 1,593 1,647 1,714 1,780 1,848 1,914 2,008 1,500 1, % 28.8% 30.3% (2) (2) (2) % % % (1) (1)

84 (1) 2012 (2) (i) (ii) (iii) 78

85 (1) (2) 55 (3)

86

87

88

89

90 (i) 2 (ii)

91 % (i) (ii) (iii) (iv) ( ) 85

92

93

94

95

96 % 125%

97

98 , ,

99 i ii iii 93

100 % 15% % %13% (i) 94

101 (ii) (iii) (a) (b) (1) (2) (i) (ii) (iii) 95

102 (i) (ii)

103

104

105 , A 2012 V-drug V-drug

106 % 5% (i)(ii) (iii) % 500,

107 ,000 90% 10% % 28.54% % 30% % % 40% 30%

108 % 5% ,600, % 30% ,600,

109 % 50% 5% 5% 5% 5% %400,000 40% 200,000 20% % 10% ,000,000 4,000,000 80% % 18% 2% ,000, %

110 , ,000, Codan Trust Company (Cayman) Limited ,00050, ,000 50, ,000,000 10, ,000 50% ,0004,000 5, % 40% ,000 60% 40% ,000, ,

111 60% 40% 100% 100% 100% 100% 100% 15.38% (1) (1) 84.62% 105

112 (a) , ,000, Codan Trust Company (Cayman) Limited (b) ,000 50, ,000 50,000 1 (c) ,000,000 80% 4,000, % 18% 2% (d) ,000 40%400,000 (e) ,790,980 90,000 90% 10% 90% 106

113 (f) ,000 10% 857, % , (g) A 8,000, ,912 A 154,368 12,000,000 A A A (h) V-drugB V-drug40,000 B 5,000,000 (i) Jumbo Success Jumbo Success 50,000 3,731,

114 (j) % (k) ,000,

115 (l) ,500, (m) (n) ,000,

116 (i) (ii) (a) A 8,000, ,912 A 154,368 12,000,000 A A A (b) V-drugB V-drug40,000 B 5,000,000 (c) Jumbo Success Jumbo Success 50,000 3,731,300 (d) V-drug (e) V-drug Jumbo Success (f) V-drug Jumbo Success B2014 (i) V-drug V-drug2,000 (ii) V-drug

117 (g) A 2014(i)A (ii) (iii)a (h) A (2014) A (2014) A (2015) A (2014) A (2015), (i)a (ii) (iii)a (i) B (2014) B (2014)B (2015) B (2014) B (2015)V-drug

118 V-drug Jumbo Success Cheung Chi Mang Li Ho Tan Fast Sino Holdings Limited 50% 47% 3% Chubu Yakuhin Co., Ltd Valor Co., Ltd. 100% V-drug Li Ho Tan 100% Jumbo Success ,912 A 154, A 40,000 B B B V-drug2,000 V-drug 31,500, % 50,000 Jumbo Success 37,500, % A 192,960, % 112

119 V-drug Jumbo Success A B A (2015) B (2015) ,000,000 (i) 6,000,000 (ii) 2,000,000 12,000,000 (i) Jumbo Success 65,000,000 10,000,000 (ii) ,000,000 3,731,300 Jumbo Success (i) Jumbo Success 10,000,000 1,538,462 (ii) % % % % % % % % 113

120 V-drug Jumbo Success (1)A (i) ,000, (ii) ,000, % % A (2014) A (2015) (2)A 50%A (1) (i) V-Drug B 5,000,000 B (ii) V-drug V-drug V-drug (iii) V-drug (a) (a) (i) %(ii) %(b) V-drug V-drug (1)Jumbo Success Jumbo Success (2) A B (i) (ii) (iii) 114

121 V-drug Jumbo Success (3)A B AB (4) (5) A B (i) (ii) (iii) (a) 5,000,000 50% (b) 10 (a) %(b) (a) %(b) V-drug (3) Jumbo Success (6) A A 115

122 V-drug Jumbo Success (7) A A (8) (a)a A A (b) A A (i) (ii) A (9)A (a) (b) A (c) % % A A (a) (b) A 10% (c)a (a) (b) 10 (b) V-drug V-drug V-drug B V-drug V-drugV-drug V-drug 5,000,000 x (1+20%) x D 365D 1,825 5x

123 V-drug Jumbo Success (10) (c) V-drug V-drug 1 V-drug B (2014) B (2015) V-drug (2) V-drug B 50% V-drug B (3)A B A B 117

124 V-drug Jumbo Success (4)V-drug V-drug (5) A B (i) (ii) (iii) (6) B B 118

125 V-drug Jumbo Success (7) B A B B B B A A A A (8) (a)b B B (b) B B (i) (ii) B 119

126 V-drug Jumbo Success (9) B B B B (a)(b) B 10% (c)b (10) V-drug V-drug V-drug 10%V-drug Jumbo Success Li Ho Tan Jumbo Success 120

127 (i) (ii) V-drug Chubu Yakuhin Co., Ltd200 Valor Co., Ltd. Chubu Yakuhin Valor Co., Ltd HKEx-GL29-12HKEx-GL HKEx-GL

128 100% Fast Sino Holdings Limited Cheung Chi Mang Li Ho Tan 3% 50% 47% 100% 100% Valor Co., Ltd. 100% Jumbo Success V-drug 65.07% 25.73% 5.00% 4.20% 100% 100% 100% 100% 100% 100% 80% 100% (1) (1) 18% 2% 122

129 100% Fast Sino Holdings Limited Cheung Chi Mang Li Ho Tan Valor Co., Ltd. 100% 3% 50% 47% 100% 100% Jumbo Success V-drug 48.80% 19.30% 3.75% 3.15% 25% 100% 100% 100% 100% 100% 100% 80% 100% (1) (1) 18% 2% 123

130 (a) (b) (i) (ii) 124

131 % % 0.05% 0.05% (i)(ii)(iii) , ,

132 % , ,

133 % 127

134 (i) (ii) (iii) , %

135 ,000 10,

136 2015 3,000 HPV 130

137 25, ,

138 (i) (ii) (iii) ,

139 ,525 5, , ,860 7, , ,053 6, , ,831 7,831 17,626 17,626 29,352 29, ,755 30, ,036 80,863 24, , ,788 22, , ,111 35, , ,349 31, , ,193 28, , ,583 14,794 24, ,832 4, , , % 87.6% 83.5% 133

140 % % % , , , , , , , , , , , , % % % , , , , , , , , , , , , , , , , , , , , ,

141 , (1) , , (1) (A) (B) 135

142 A B (1) (1) 136

143 A B % 69.0% 63.1% % 1.3% 0.9% 137

144 15,

145 ,211 1,296 1, (277) (316) ,296 1, (i) (ii) (iii) 50, ,000 90% (i) (ii)

146 , % 21.3% 24.5% (i) (ii)iii (iv) (v) (vi)(vii)

147 (i) (ii) (iii) (iv) (v)(vi) 141

148 (i) (ii) (iii) 5,000 (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) (ix) ,411 1,391 1,

149 , ,093 1,112 1, ,452 1,397 1,

150 ,437 1,452 1, (55) ,452 1,397 1, (i) (ii) 144

151 (iii) (iv) (v) (i) (ii)(iii) 145

152

153 , ,

154 ,154 5% ,350 3,744 3, ,494 3,953 3, ,156 1,630 1, , ,114 2, (i) (ii) 148

155 (1) (2) (1) (2) 149

156 % 24.4% 32.3% 30.2% 33.9% 41.7% (2) (1) 11 (3) (1) (2) (3)

157 (7) (1) (1) % 90% 10% % 151

158 % (i) (ii) (iii) V-drug V-drug V-drug Valor Co., Ltd Chubu Yakuhin Co., Ltd 100% V-drugChubu Yakuhin Co., Ltd Chubu Yakuhin Co., Ltd Valor Co., Ltd. Chubu Yakuhin Co., Ltd 152

159 % , (i) 60 (ii) 32 (i)375 (ii)

160 (i) (ii) (A) (B) 2013 V-Drug ,000 25,000 25, % 20.8% 20.9% (i) 1000 (ii) 5,

161 ,000 20, (i) (ii) (iii) 155

162

163 76.5%

164 ,979 3,623 3, ,174 3,827 3, ,263 1, OMEOK ,374 By-health Alivegreen SI-KI Shijian ,282 2,243 Momcen Doctor Radiation 158

165 (1) (2) (1) (2) 159

166 % % 10.2% 13.1% (i) 160

167 (ii) (i) (ii) (1) (2) (3) 161

168 (1) (2) (3)

169

170 % 90.5% 92.0%

171 (1)

172 (1) D % 65% % % % ,010, , ,010, , ,010, , ,000 4, ,000 7, , ,000 10, ,000 10, ,000 15, (1) (2) 1,000 (3) (i) (ii)

173

174

175 (6) (2)

176 (i) (ii) (iii) (i) (ii) (10) (i) (ii) 170

177 (i) (ii) (i) (ii) (i) (ii) (iii) (iv) % 171

178 (i)(ii) 50% (iii) (iv) (v) (vi) (i) (ii) 10% 2, % 25.4% 29.5% 4.6% 9.5% 8.0% 172

179 % (1) E M 30 B J 30 O 30 (1) 173

180 (1) A B C D E (1) 174

181 (1) C B E F D (1) 175

182 % 10.2% 13.1% % 38.2% 43.6% 9.8% 9.8% 13.7% % (1) E H K J F (1) 176

183 (1) A 30 H 30 C 30 E 30 D 30 (1) (1) E 30 C 30 D 30 I 30 H 30 (1) 177

184 (i) (ii) 30% 50% (iii) (i) (ii) 30% (iii)

185 % 8.2% 8.3% % 16.1% 11.3% % % % % 13.0% 11.9% % 3.8% 4.8% 179

186 (i) (ii) (iii)(iv) 180

187 (i) (ii) (iii) (i) A (ii)b (iii)c 181

188

189 (i) (ii) 183

190 (i) (ii) (iii)

191 HPV (i) (ii) (i) HPV (ii)(iii) (iv) (i)20.0 (ii)(a)3.0%(b) 2.0% (i) (ii) (iii) (iv) 185

192 % 1.2% 0.8%

193 AA

194

195

196 (i) (ii) (iii) (iv) 190

197 (i) (ii) 191

198

199 %

200 ,

201 6, ,176 33, ,040 2,

202 11, % % 43.8% 45.3% 21, ,

203 (1) (2)(3) (4) (5) (1) (2) (3)

204 (1) (2) (3) (4) (1) (2) (a) (b) 1% 2% 5% 10% (3) (4) (5) 198

205 (1) (2) 1 4 (3)

206 10% %

207 (a) 15 (b) (c) (d)(e) (a) (b) (c)(d) 201

208 36 31, , , (1) (1) (A)

209 16 16 (B) (C) 1,000 10,000 1,000 10,

210 % 2.1% 3.4% % 0.2% 0.1%(i) (ii)(iii) (iv) (v) , (1) 1% 15% 38(1)34(2) 204

211 (i) (ii) (iii) (iv) (v) 205

212

213 (I) % % (i) ;(ii) (iii)

214 (II) ,000 50,

215 (1) (2) (3) (4)

216

217 30% (i) (ii) 211

218 % 25% 20% , , ,

219 ,000 29, % 10% 50% 213

220 ,632, , , (II) ,054,000 1,186,000 85,

221 (i) (ii) (a)(b) 215

222 (a) (i) 5% (ii) 5% (b) (i) (ii) (iii) 30% (i) (ii) 216

223 (iii) (iv) (v) (vi) 217

224

225 Li Ho Tan

226

227 (2) (2) 221

228 (2) (2) LI HO TAN Li Li (2) Goldman Sachs Japan Co., Ltd (2) 222

229 (2)

230

231 Chu Lung Hai, Jimmy & Co. CPA Deloitte Haskins & Sells (University of New England) (University of Southampton) (2) (2)

232

233 Ernst & Young LLP California Board of Accountancy (CFA) (York University) 227

234 A (a) 3A (b) (c) (aa) (bb) (cc) (d) 3A

235 (e) 3.21 C (2) B

236 D , , , , ,000 1,386,

237 2,000,000,000 2,000,000 (%) 1,000,000 1, ,000, , ,000, , ,000,000,000 1,000, ,000,000,000 2,000,000 (%) 1,000,000 1, ,000, , ,000, , ,500,000 37, ,037,500,000 1,037,

238 2. 2(c) (i) 20% (ii) (i) (ii) (iii) 232

239 % (i) (ii) (iii)

240 XV2 3 10% (1) , % 488,040, % (1) , % 488,040, % Li Ho Tan (2) , % 230,460, % (2)(3) , % 192,960, % Cheung Chi Mang (3).. 257, % 192,960, % (1) 488,040,000 (2) Li Ho Tan 47% Jumbo Success Li Ho Tan Jumbo Success 192,960,00037,500,000 (3) Cheung Chi Mang 50% Cheung Chi Mang 192,960,000 XV2 3 10% 234

241 (i)(ii) (i)(ii) (iii)

242 % % 0.05% 0.05% ,097 9,555 10, ,534(i) (ii) (iii) (iv) (v) (vi) % 236

243 ,500 (i) (ii)(iii) % 18.6% 27.6%

244 ,

245 % 90.5% 92.0% % % % 5% (27,519) (296)% (30,305) (48)% (30,423) (66%) 3% (16,511) (177)% (18,183) (29)% (18,254) (40%) 1% (5,504) (59)% (6,061) (10)% (6,085) (13%) 5% , % 30,305 48% 30,423 66% 3% , % 18,183 29% 18,254 40% 1% ,504 59% 6,061 10% 6,085 13% (i) (ii) 239

246 240

247 i. ii. (ii)(i) 241

248 242

249

250 244

251 , , , (582,575) (643,924) (665,126) , , , ,379 14,612 20, (710) (33,380) (35,990) (36,468) (25,137) (25,779) (46,729) , , , (3,453) (5,855) (9,013) (4,714) (51,881) (16,134) (33,236) ,418 81,312 71, (17,110) (18,243) (25,740) ,308 63,069 46, ,409 63,070 45, (101) (1) ,713 5,396 (5,929) ,021 68,465 40, ,122 68,466 40, (101) (1) ,021 68,465 40,200 (1) ,189 79,203 79,

252 (1) (i) (ii)(iii) ,525 5, , ,860 7, , ,053 6, , ,831 7,831 17,626 17,626 29,352 29, ,755 30, ,036 80,863 24, , ,788 22, , ,111 35, , ,349 31, , ,193 28, ,

253 ,525 74, % 695,860 89, % 707,053 98, % ,831 3, % 17,626 5, % 29,352 9, % ,755 52, % 80,863 55, % 110,788 73, % , , , , , ,

254 (i)(ii) (iii) (i)(ii) (iii) (i) (ii) ,861 15,803 13,154 1,296 1, ,452 1,397 1,422 1, % 1.1% 0.9% 248

255 , , , , , , , , , , , , (i) (ii)v-drug (iii) ,583 14,794 24, ,832 4,

256 % 23.3% 16.7% ,339,954 82, ,760,175 79, ,393, , ,589,642 20, ,562,199 20, ,124,754 21, ,662, , ,116, ,024,260 5, ,918,336 4, ,004,100 7, , , ,635, ,153, ,980, , , , % 18.9% 21.5% 250

257 , % 703, % 713, %.... (568,548) (90.2)% (623,327) (88.6)% (623,317) (87.3)% , % 79, % 90, % , % 17, % 29, %.... (5,067) (64.7)% (12,211) (69.3)% (19,848) (67.6)% , % 5, % 9, % , % 105, % 132, %.... (41,319) (37.6)% (38,889) (36.9)% (50,300) (37.8)% , % 66, % 82, % % 11.4% 12.7% (i) (ii)

258 % 30.7% 32.4% V-drug Chubu Yakuhin Co., Ltd. V-drug Chubu Yakuhin Co., Ltd. V-drug (i) (ii) 252

259 ,921 2, % (847) 9,935 4, % (1,203) 16,546 8, % (447) % (869) 2, % (4,946) 3,302 1, % (4,520) (i) (ii) (A) (B) (i) (ii)

260 % 63.1% 62.2% (%) (%) (%) , , , , , , , , , (249) (47.2) (39) (22.9) (16) (4.1)

261 % 4.3% ,096 13,789 10, ,832 6,658 6, ,331 6,292 7, ,052 4,394 5, ,117 4, ,783 2,505 1, ,380 35,990 36,

262 % 3.1% 5.5% % % % % (i) (ii) (iii) (iv) (v) 256

263 ,178 9,794 13, ,400 3,557 1, ,599 1,427 4, ,954 1,677 4, ,346 2,720 11, ,886 1,924 3, ,062 1,577 1, ,207 2,308 3, , ,137 25,779 46,729 (i) (ii)

264 ,955 10,884 13, , ,418 1, (1) ,152 1,160 2, ,379 14,612 20,672 (1) (i)2014 (ii) 2012 (iii)(iv)(v) ,

265 (81) (32) (1,992) (2) , (710) ,868 4,114 4, ,293 3, ,453 5,855 9,

266 A V-drug B A B

267 ,418 81,312 71, ,161 19,465 26, (1,051) (1,222) (884) ,110 18,243 25, % 22.4% 35.8% ,361 18,579 22, % 22.8% 31.4% (1) ,299 97, , % 19.1% 21.5% (1) 261

268 % [2011] % % 22.4% 35.8% % 22.8% 31.4% 262

269 19.6% 19.1% 21.5% 40% % 20% 18% 2% % % (i) (ii)

270 % % (i) (ii) % % % % % % % 264

271 % % % % % % % % % (i) (ii) (iii) % (i) (ii) (iii) (iv) 265

272 (v) % (i) (ii) (iii) , (i) % % % % %

273 % % % % % % (i) (ii) % (i) (ii)(iii)

274 (i) (ii) (iii)v-drug % % % % % % % % %

275 % % % (i) (ii) % % % % (a) 2013 (b) (i) (ii) (i) (ii) (i) (ii) %

276 , % % % % % A B %

277 % % (42,242) 92,225 48, (2,698) (105,599) (16,294) ,067 39,935 (30,933) (10,873) 26,561 1, ,120 39,227 65, (20) (413) ,227 65,375 67,

278 (i) (ii)24.6 (A) (B) (C) (iii) (iv) (v) (i) (ii) 53.9 (iii) (i) (ii) 21.0 (i)115.6 (ii)

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