R318 A tidemark X 0. 15% ~ 0. 3% I % Wang 1 10 ~ 277 μm 104 μm ± /mm 2 9 5

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3 R318 A tidemark X 0. 15% ~ 0. 3% I % Wang 1 10 ~ 277 μm 104 μm ± /mm Ⅱ /10 DOI /j. issn dxj9@ 163. com

4 OPG /RANKL /RANK OPG /RANKL /RANK 9 matrix metalloproteinase 9 MMP / OPG /RANKL / RANK NF - κb receptor activation of NF - κb ligand RANKL TNF NF - κb receptor activation of NF - κb RANK Ⅰ 1 RANKL RANK osteoprotegerin OPG OPG 2 RANKL RANKL RANK OPG /RANKL 20 OPG / RANKL OPG / RANKL MPa 5. 7 Gpa

5 3 4 5 porogen leaching 2 stereolithography 29 bioprinting electrospinning Mouthuy - Cui PLGA Lee Chen - TGF - β3 Ⅰ PLGA MSCs Hoemann Gao 3 mm

6 Proc Natl Acad Sci U S A Watanabe H Watanabe H cartilage J. Clin Calcium Wang F Ying Z Duan X articular calcified cartilage zone J 35 ~ 37 biochemistry and physiolo- 10 Huber M Trattnig S Lintner F. Anatomy Wakitani MSCs Ⅰ gy of articular cartilage J. Invest Radiol Knudson CB Dev Biol Imhof H Sulzbacher I Grampp S 2002 MSCs the pathogenesis of osteoarthrosis J repair J. Knee Surg Sports Traumatol Arthrosc Gomoll AH Madry H Knutsen G J. Knee Surg Sports Traumatol Arthrosc ~ Orth P Goebel L Wolfram U model at 6 months J. Am J Sports Med Feng X McDonald JM. Disorders of bone remodeling J Pathol Nishitani K Shirai T Kobayashi M a rabbit osteochondral defect model J Francioli S Cavallo C Grigolo B 1 Getgood A Brooks R Fortier L et al. Articular cartilage tissue engineering today's research tomorrow's practice J. J Bone Joint Surg Br B Filardo G Kon E Roffi A et al. Scaffold - based repair for cartilage healing a systematic review and technical note J. Arthroscopy McNickle AG Provencher MT Cole BJ. Overview of existing cartilage repair technology J. Sports Med Arthrosc Griffith LG Naughton G. Tissue engineering - current challenges and expanding opportunities J. Science Hoemann CD Lafantaisie - Favreau CH Lascau - Coman V et al. The cartilage bone interface J. J Knee Surg Castro NJ Hacking SA Zhang LG. Recent progress in interfacial tissue engineering approaches for osteochondral defects J. Ann Biomed Eng Reddi AH Gay R Gay S et al. Transitions in collagen types during matrix - induced cartilage bone and bone marrow formation J Kimata K. The roles of proteoglycans for et al. Histomorphometric analysis of adult. J Struct Biol Knudson W. Cartilage proteoglycans J. Semin Cell et al. Subchondral bone and cartilage disease a rediscovered functional unit J. Invest Radiol 13 Burr DB. Anatomy and physiology of the mineralized tissues role in. Osteoarthritis Cartilage Gupta HS Schratter S Tesch W et al. Two different correlations between nanoindentation modulus and mineral content in the bone - cartilage interface J. J Struct Biol Madry H. The subchondral bone a new frontier in articular cartilage et al. The subchondral bone in articular cartilage repair current problems in the surgical management J. et al. Effect of subchondral drilling on the microarchitecture of subchondral bone analysis in a large animal. Annu Rev et al. Positive effect of alendronate on subchondral bone healing and subsequent cartilage repair in. Am J Sports Med et al. Engineered cartilage maturation regulates cytokine production and interleukin - 1beta response J. Clin Orthop Yang PJ Temenoff JS. Engineering orthopedic tissue interfaces J. Tissue Eng Part B Rev J Mente PL Lewis JL. Elastic modulus of calcified cartilage is an order of magnitude less than that of subchondral bone J. J Orthop Res Hutmacher DW. Scaffolds in tissue engineering bone and cartilage J. Biomaterials Mouthuy PA Ye H Triffitt J et al. Physico - chemical characterization of functional electrospun scaffolds for bone and cartilage tissue engineering J. Proc Inst Mech Eng H Lee CH Cook JL Mendelson A et al. Regeneration of the articular surface of the rabbit synovial joint by cell homing a proof of concept study J. Lancet M / / J.

2003 23 1628-1630. 30. J. 2173-2186. 2005 5 390-393. 37 Sheehy EJ Vinardell T Buckley CT et al. Engineering osteochondral 31 Cui W Wang Q Chen G et al.

7 J Sheehy EJ Vinardell T Buckley CT et al. Engineering osteochondral 31 Cui W Wang Q Chen G et al. Repair of articular cartilage defects constructs through spatial regulation of endochondral ossification with tissue - engineered osteochondral composites in pigs J. J Biosci Bioeng Chen G Sato T Ushida T et al. Tissue engineering of cartilage using a hybrid scaffold of synthetic polymer and collagen J. Tissue Eng Hoemann CD Sun J Legare A et al. Tissue engineering of cartilage using an injectable and adhesive chitosan - based cell - delivery vehicle J. Osteoarthritis Cartilage Gao J Dennis JE Solchaga LA et al. Repair of osteochondral defect with tissue - engineered two - phase composite material of injectable calcium phosphate and hyaluronan sponge J. Tissue Eng Jiang J Tang A Ateshian GA et al. Bioactive stratified polymer ceramic - hydrogel scaffold for integrative osteochondral repair J. Ann Biomed Eng Lee JC Lee SY Min HJ et al. Synovium - derived mesenchymal stem cells encapsulated in a novel injectable gel can repair osteochondral defects in a rabbit model J. Tissue Eng Part A J. Acta Biomater Wakitani S Imoto K Yamamoto T et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees J. Osteoarthritis Cartilage Allan KS Pilliar RM Wang J et al. Formation of biphasic constructs containing cartilage with a calcified zone interface J. Tissue Eng Ito Y Adachi N Nakamae A et al. Transplantation of tissue - engineered osteochondral plug using cultured chondrocytes and interconnected porous calcium hydroxyapatite ceramic cylindrical plugs to treat osteochondral defects in a rabbit model J. Artif Organs Benders KE Weeren PR Badylak SF et al. Extracellular matrix scaffolds for cartilage and bone regeneration J. Trends Biotechnol A Ambroise Pare Ⅱ Ⅱ Ⅳ Ⅲ Ⅱ Ⅱ ~ 1538 International Orthopadics SIOOT

Microsoft PowerPoint - 151216 Cartilage tissue engineering bilingual traditional FINAL 2

Microsoft PowerPoint - 151216 Cartilage tissue engineering bilingual traditional FINAL 2 Cartilage Tissue Engineering 軟骨組織工程 Dr. Barbara Chan 陳佩博士 Mechanical Engineering The University of Hong Kong 香港大學機械工程 By 2050 2 billion people over 60 years old 2050年 20億年齡在60歲以上的人 2 in