IMS 7.2% 7.3% 7.4% 2,000 31 10,000 14 17.1% 20 30 235.6 401.4 560.6 393.0 82.3%, 78.7%, 79.1% 83.0%17.3 46.2 55.5 30.7 6.0% 9.1% 7.8% 6.5% 33.4 61.2 84.8 49.1 11.7% 12.0% 12.0% 10.4% 66.5% 60.1% 57.3% 57.7%
13 19 12 % % % % % (1)... 255,436 89.2 423,123 83.0 549,875 77.6 253,017 78.5 359,110 75.9... 28,996 10.1 76,375 14.9 115,743 16.3 52,465 16.3 75,004 15.8... 1,917 0.7 10,550 2.1 43,289 6.1 16,912 5.2 39,323 8.3... 286,349 100.0% 510,048 100.0% 708,907 100.0% 322,394 100.0% 473,437 100.0% (1) 2,000 31
10,000 89070% 3,600 55% 5,400 278 333 13 30 10 10% GMP GMP
286.3 510.0 708.9 57.4%178.8 233.4 313.7 32.5% 179.3 237.1 326.3 34.9%473.4 247.4 254.8 Sanofi-Aventis Pfizer 17.1% 58.1% 2,000 31 10,000 890 70% 3,60055% 5,400
278 200 2,000 44 1,664 81.8% 4,668
22.9% 44 19 44 12 33311 134 289 44 30 10 10%
15 17 17 20
500 90% 80% 70%
GMPFDA 10010300 30 44 33
14 11 19 4 6 1 3 5 44 (2) (1) (1) (1) (1)
(2) (1) (1) [2007]42 [2009]387 [2010]394 (2) 245.3 432.1 623.6 434.3 14 10453 24.0% 29.2%
% % % % %... 177,505 62.0 258,822 50.8 330,864 46.7 148,203 46.0 215,899 45.6... 13,010 4.5 47,523 9.3 75,252 10.6 35,606 11.0 57,018 12.1... 29,140 10.2 49,580 9.7 63,080 8.9 29,554 9.2 41,809 8.8... 4,581 1.6 23,126 4.5 37,176 5.2 19,369 6.0 24,303 5.1... 1,775 0.4 22,837 3.2 7,877 2.4 31,277 6.6... 12,383 1.8 4,342 1.4 12,746 2.7... 11,349 4.0 20,539 4.0 19,029 2.7 9.849 3.0 9,956 2.1... 235,585 82.3 401,365 78.7 560,621 79.1 254,800 79.0 393,008 83.0 80320 14.4% 15 195.4 66.1% 29 2,500 80
0.0093% 510.0051% 2,515 341.35%...... 320 600... 7 14 30... 20
66.5% 60.1% 57.3% 57.7% 493.2 183.4 28.1% 58.1% 120
733.9501.9 10.0% 22.4% GM1 GM1 GM1 GM1 1,869.3 133.3 93.5% GM1 GM1 1,319.5138.2 75.8%
11 661 22.4% 27.1% % % % % %... 4,988 1.7 19,706 3.9 18,609 2.6 9,547 3.0 7,357 1.6... 4,233 0.8 16,130 2.3 7,226 2.2 11,521 2.4... 12,335 4.3 22,290 4.4 20,778 2.9 10,295 3.2 11,781 2.5 12 805.7329.3 25.1% 14.3% 13 1,000.695.6 79.9%
61.9 7.0 72.4% % % % % %... 3,180 1.1 17,096 3.4 36,513 5.2 16,787 5.2 19,523 4.1 (1)... 14,727 5.2 17,270 3.4 16,143 2.3 8,211 2.6 10,436 2.2... 15,534 5.4 26,808 5.3 32,164 4.5 14,827 4.6 19,161 4.1 (1) Feidiao Pudiao Quxinao 1530
1,710.8 552.0 32.7% 238.8%COS Feidiao Pudiao Quxinao 495.0 176.5 29.4% 527.7204.3 26.8% 2,000 10,000 278
278 27 251 50 31 200 2,000 GSP 2,000 89070%3,60055%5,400
GSP (i) (ii) (iii)
0.004% 0.004% GSP GSP
(1) (2) (3) 1,594 1,773 2,398 2,022
30.0% 21.6% 19.6% 16.9% 12.3% 7.4% 6.2% 4.6% 3.9% 14.2% [2010]253 46.7% 10.6% 0.3%
1) 1) 1) 1) 2) 2) 2) 2) 3) 3) 3) 3) 4) 4) 4) 4) 5) 5) 5) 5)
62.4 61.5 61.5 61.5 211.6 197.1 197.1 197.1 80 56 56 50.6 50.6 120 69 69 69 69 359 4 99237 333 11 134 289 10
(i)(ii) (iii) (iv) 23 CCV 171 6 159 44 13 27 26
65.0 36.4 48.2 10%... 286,349 510,048 708,907 473,437... 65,000 36,370 48,203 50,794... 22.7% 7.1% 6.8% 10.7% (1)... 4,394 8,435 13,697 9,137... 2,355 5,851 15,617 9,132... 55,927 14,369 7,264 19,897... 2,324 4,344 5,666 9,941... 3,371 5,959 2,687 (1) 10.76.2
30 10
182.5% EvaluatePharma 12
20 2,800,000 200,000 300,000 300,000 500,000 3,500,000 7,300,000 15,000,000 GMP 25,329 15,305 GMP62.5 3 505608
(1 (%) (%) (%)... 3,000,000 1,760,000 58.7 3,020,000 101.0 (2) 3,030,000 101.0 (2)... 62,500,000 26,810,000 95.7 (3) 35,810,000 57.3 45,270,000 72.4... 50,000,000 49,120,000 98.2 21,100,000 42.2 16,450,000 33.0... 560,000,000 427,000,000 76.2 373,000,000 66.6 337,000,000 60.2... 8,000,000 3,160,000 39.5 6,390,000 80.0 2,030,000 25.4 (1) 250 (2) 100% (3) 2,8006,250 3 27 100 10 300
50 300 84.7% 68.1% 63.6% Harbin Tri-Lion Pharmaceutical Co., Ltd. 25.2% 34.3% 28.0% 51%
21 11 GMP 10 11 11
67.6 156.4 197.1 23.6% 30.6% 27.7% 111.0 23.4% 31.7 93.0 104.0 52.4% 69.6% 54.2% 12 0.7% 2.1% 6.1% 8.3%
26 GSP GMP GMP
28,000 20,000 6,000 GSP GMP
90 84 77 99 233 4 10 20 156 85 10
IMS 3,600 20 24.7% 2.2%
100 BayerSimcere Pharmaceutical GroupGM1 58.1% Hefei Pingguang Pharmaceutical Co., Ltd. 16.4% 22.4% Ebewe Pharma Ges.m.b.H. Nfg. KG 41.7% 5.0% 3.2% Heilongjiang Harbin Medical University Pharmaceutical Co., Ltd. GMIGM159.8% 23.0% 7.9% 14.3% 12.8% 8.8% 13.6% Zhejiang Jianfeng Pharmaceutical Co., Ltd. Guilin Aolin Pharmaceutical Co., Ltd. 46.8% 28.1% 4.3% Beijing Kaiyin Pharmaceutical Co., Ltd. Beijing Huasu Pharmaceutical Co., Ltd. 17.1% 9.9% 5.4% Boehringer Ingelheim International Trading Co., Ltd. Shenyang New Horse Pharmaceutical Co., Ltd. 33.4% 15.4%
72,009.6 20,138.0
23,374.1 153,970.52 500,000 2.85 API 2,931.50 781.5 API 5 API 150,000 API 100,000 50,000 10,000 100,000 100,000 274,557.2 2,178 150,000
65,340 80 80 50 30,000 30 30 3,350.4 480,000 2.8 886,003 144.64 11,000 API
10
GMP GMP
51 (3) 1. H20020088 H20020125 (4) 80 (1) 2. H20061204 (4) (1) 320 3. (2) Z20050247 Z20055421 0.525 4. H20051134 H20051685 220 (1) 20 (4) 5. (1) H20060556 0.4 6. (1) H20060351 H20060555 1 7. (1) H20060554 2 8. H20055217 60 (4) 9. H20064521 0.25 10. H20055760 22 (4) 11. H20055759 11 (4) 12. H20055758 10.4 (4) 13. H11020127 0.25 14. (1) H20051024 H20051518 0.3 15. (1) H20051023 H20051517 16. H20058155 0.25 17. H20063944 60 18. H20066943 40
(3) 19. H20063941 20 20. H20063942 80 21. H20044990 1.2 110 (4) 22. H20093221 10 23. H20073958 20 24. H20073971 40 25. H20074007 80 26. H20083224 220 27. H20080100 0.25 1.25 28. H20084309 40 29. H20084310 80 30. (1) H20080046 H20080102 0.5 31. H20080401 50 32. H20056285 0.25 33. H20059159 34. H20067160 35. H20064033 36. H20084282 2 37. H20084283 4
(3) 38. H20084284 8 39. H11020128 0.1 (4) 40. H11020125 10 (4) 41. H11020126 0.1 (4) 42. H11020121 80 43. H11020123 1 44. H11020124 2 (4) 45. H20000671 3 46. (1) (1999)X-28 H19991046 0.1 47. H20055755 40 (5) 48. H20055757 49. H11020122 50. H20020124 51. H20103399 (1) 1 4 6 14 1530 46 (2) (3) (4)
(3) 1. H20020268 H20020386 (2) 50 (4) H20051062 0.1 (4) H20051063 0.2 (4) 2. (1) H20030414 H20030553 0.12 (4) H20041175 80 (4) H20041171 40 (4) 3. (2) H20051206 H20051750 10 (4) H20051751 20 (4) 4. H20030570 H20030735 0.15 (2) (4) 5. 1 H20055557 2 1 (4) H20055558 2 (4) 6. H20065159 0.5 H20065160 1 7. Z20026460 (4) 8. (2) Z20050167 Z20050158 (4) 9. (2) H20050661 H20050987 0.3 (4) H20050988 0.6 (4) 10. (2) H20050935 H20051202 (4)
(3) 11. 1.5 3 H20040716 0.75 1.5 (4) 2.25 H20044347 3 (4) 2:1 H20044346 (0.75 ) (4) H20045273 2.25 (4) 12. 0.5 1 H20043923 2 1 (4) H20045271 0.5 (4) H20045272 2 (4) 13. H20080049 H20080106 (2) 14. H20070005 1 15. H20084170 0.75 H20084172 1.5 16. H20040620 H20060214 (2) (4) 17. H20034162 100 (4) H20034161 200 (4) 18. H20057878 530 H20057879 1060 19. 1080 H20054513 1070 1080 (4) H20054512 1070 (4) 20. (2) H20051764 H20052581
(3) 21. H20056325 (4) 22. H20068014 (4) 23. H20067414 80 H20067415 60 H20066943 20 24. ( ) H20080592 2030 25. H20070034 0.25 (4) H20056297 0.5 (4) H20056298 1 (4) H20056295 1.5 (4) H20056296 2 (4) 26. H20044468 0.5 (4) H20058717 1 (4) H20058718 2 (4) 27. H20063806 2 28. H20054704 24 (4) 29. H20045991 1 (4) 30. ( H20060154 ) 15 H20060155 30 31. H20056134 40 (4) 32. Z20025400 0.28 (4)
(3) 33. H20052588 10 34. H20084087 0.25 35. H20084086 0.1 36. H20084383 0.5 37. H20084384 1 38. H20084032 530 39. H20084033 16.7100 40. H20093094 0.2 (1) (2) (3) (4) API
[2007]42 [2009]387 [2010]394
GMP Jing G0153 L5157 Jing G0181 Jing I0275 I4396 Jing J0356 GMP
12 300,000 (i) 122(1) (ii) 122(1A) China Pharma 2,019,922 131,600 China Pharma China Pharma China Pharma
China Pharma [2006]27 [1999]30 18 50% 18% 20% 22%2007(39) 11%22% [2007] 39 [2007]39 [2009]69 [2009]69 [2007]39 25% [2009]69[2007]39 12.5%
[2010]15715% 12.5% 15% 9% 10% 11%... 33% 25% 25% 25% (1)... 7.5% 15% 15% 15% (2)... 12.5% 12.5% 12.5% (3)... 7.5% 18% 20% 22% (4)... 7.5% 9% 10% 11% (1) (2010)15715% (2) (2009)69 (3) (2007)39 (4)
15% 23,800,000 60 60 10,000 200,000
395 598 841 181 21.5% 266 31.6% 189 22.5% 131 15.6% 74 8.8% 841 100% 1.1 - (i) (ii) (iii)
(iv)