( )
...1... 10... 10 4... 11... 12... 13 9... 15... 17... 18... 20... 25... 33... 36... 37... 39... 40... 43 SARS... 45... 51
... 60... 64... 66 PMWS... 68 ( )... 74... 76... 80 ( )... 81... 83... 84... 87... 91... 100... 105... 108... 109...118...119... 122... 125... 128 ( )... 130 II
... 130... 131... 134... 136... 136... 137... 141... 143... 145... 147... 148... 150... 158... 159... 167... 176... 177... 179... 187... 197 /... 198 III
1. 4 (1) 2 2 (2) 1
(3) (4) 2 57 171-176 -60 2. (1) 2
(2) (3) 2 2 1 (4) (5) 3 3
2 2 4. G G C B1 G G C B1 50g/L 4
ph 200ml/L 5. 9g/L 50g/L 100g/L 60g/L 250g/L 10-25mL 5
CoA K3 G G C ATP CoA C 50g/L 6. B1 B1 K G 6
C 7. ATP CoA C ATP C G G CoA G G 8. (1) (2) 7
(3) (4) 1 CoA 9. 8
10. K CoA 200mL/L 6-12h 1 PH 9
2000 150 10
4 11
56 30 60 10 70 40 48 6 12
2 6 13
14
9 1/3 15
1/3 1 333 350 100% 9 16
H5N1. AN-TON RYCHENER 17
H5N1 18
10 15 50 20% 30% 5 10 50 10% 20% 19
2 3 100 2% 3% 5 10 100 5% 10% 0.5 100 0.5% 87% 36% 25% 3 4477 20
45.8% 10% 21
r- 22
14 35-40 1 23
70% Bla Bla 1-2 2-3 1-2 10-14 6 24
1-2 1210 0.03% 0.3%-0.5% 25
2% 1 2 2 20 1 ( ) 6 (1) (2) 26
( )7 1~2 ( )8 ( )9 1-2 ( ) 6 40 (K88 K99 987P) ( ) 2 15 20-15 ( ) 1 ( ) 1 / 5 2 0.1% 27
2 ( ) 1-3 12 0.1% 0.5 33-34 ( ) ( )2 10 7-15 ( )3 20 ( )4 30 ( )8 ( ) 2-6 ( )5-6 ( ) 4-6 2 8 ( ) 1 28
1 1 ( ) 2 20 ( ) 6 ( ) 30 ( ) EM 7 7 29
0.1% VE1.0 ( ) 0.2-1.0 / 10 0.2-0.6 / 1. 2. 1-2 3. 4. 5. 2 30 6. (1) 2PPM 100 7 0.3 / 7-10 30
(2) 8 / 10-20 / 2-3% 0.10-0.12 7.0 7-10 (3)1-2% 50-100PPM 10 1 1% 3-5 / 1 /4 3 2.5-8 / 1 1-2 3-5 31
0.75-1 / 2-4 1 2 110PPM 3-8 55PPM 100PPM / 10 15 / 1 2 5 10 15 / 3 1 1.5 / 40PPM 20PPM 50 / 10 30 / 1 2 3 ( ) 100 3 55 80PPM 45 110PPM 10-30 / 2 10 / 3 0.5% 3-5 / 1 2 3 ( ) 10-12 / 1 32
2 5-7 300PPM 14 100PPM +SM 2 100PPM 120-360PPM 400PPM +100PPM SM 2 ) 10% +VC 10 1. 2. 90-100% 5-7 10 33
3. 4. 1. 2-5 10 50-100% 2. 3-7 3. 4. 90% 10-20 10-30% 20kg 34
1. 2. 3. 10 4. 1. 2. 3. 500 15 10 15 35
10kg 6-8 15kg 4-5 4. 20% 5. 5% 3-5 E 6. 654-2 36
75% 37
100 38
39
2004 1 29 26 3 26 50% 1. 40
2. 3. 3.1 41
1~3 30~34 4~7 28~30 15~30 22~25 2~3 1-2ml 5-7 3.2 8~15 3.3 42
3.4 25~30mg/kg 5~7 2~3 1. 2-3 43
20-25 60-70 2. 4-6 3. 30-50 50-60 70 70 15-30 1 15-30 1 4. 40-41 15-30 1 15-30 44
1 5. 40-41 21 3-18 SARS SARS 20 SARS SARS 3 19 45
SARS - 6 60 1 23 2001 27.6 380 2000 20 2001 630 27 46
200 (GDP) 2.5% 1100 2/3 200 54 W.MCHEILL 65 50 46 35 26 - SARS 47
- 9 11 SARS SARS 48
SARS - 49
SARS WTO - WTO - 50
51
( ) 15 20% 2 7-15 24 24 ( ) ( ) 52
70% 100% 10%-20% 1-2 100% 53
1-3 - 0.1% 38%-40% 54
10 2-4 0 20 80%-90% 3-5 3-4 8-46 5% 55
( ) ( ) ( ) ( ) 80-120 ( ) m3 5-25 2-4 56
( ) 3-5 1-2 0.2-0.3kg/cm 2 ( ) 57
30% 16% A B 10 03%-0.5% A.B l0 60 30% 10 58
( 10% 20% ) 59
60
1. 2. 3. 61
4. 2 3~5 37 ~36 1. 62
11.72MJ/kg 13% 2. 1~3 34~30 4~7 30~28 15~30 25~22 60~80cm 3 3 3. 63
4. 5 50~100g 20% 5ml 4 3 20% 10ml B 2ml 0.5ml 3 1ml 3 3 ( ) 1 1.5 2 21 20 50 60 1 1 1.5 1 1 10 1 64
( ) 35 70 1 ( ) 30 35 ( ) 45 15 1 1 2 / ( ) 30 15 1 ( ) 1 1 ( ) 1 3 5 0.1% 1 0.1% 15 1 3 4 1 15 1 ( ) 4 1 65
( ) 1 1 20 25 1 ( ) 3 7 21 0.5 ( 1) 1 5 1 4 6 1 1 1 1 1 60 70 1 4 6 1 5 6 1 4 6 66
1 1 3 4 1 10 11 1 1 2 1 10 1 4 1 2h 20 25 4 60 65 67
2 4 PMWS PMWS PMWS PCV PCV I PCV-1) II PCV-2) CAV PBFD PCV SCSV CFDV BBTV PMWS PMWS 4-14 18-24 68
PCV-2 PDNS 12-14 18-24 PDNS III PDNS PDNS PCV-2 PCV-2 69
PDNS PMWS PMWS PDNS PRRS PCV-2 PDNS PDNS PCV-2 Lawsonia intracellularis PCV-2 PMWS 2 5 10 70
71
PMWS PMWS PMWS (95% ) 3 3kg/T 4kg/T 2kg/T 3kg/T 0.5-0.8% NaHCO3 1. 2. 72
3. 24 30kg 1. 13 2. 3. 3 / 4. 5. NH 3 <10ppm CO 2 <0.15% 6. 7. / 110kg 1. 2. 3. 4. 5. >0.75m 2 / 6. 1. 2. 73
3. 4. PMWS PCV DNA ( ) 15-45 24 74
50 3 LD50 1mg/kg 2001-2003 90 4485 135 81.83% 75
1. 2. 1000g 1000 3. 10 76
1. 8-15 2. 3. 20 5 15 10-13 C B12 B6 4. 77
20% 60% 90% 5. 4% 6. 4 10-15 7. 90% 78
8. 9. 1. 2. 3. 4. 20 79
5. ( ) 30 80
48 1. 2. 80% 4-6 K1 ( ) 81
4557 170 3 170 30-40 3 1. 20 6 14 2500 1/4 15 82
68000 7-8 1989-1993 25 10 5-10 5 1. 10 5 2. 100 50 3. 3 83
60 Talfan 35 Talfan ECSO ECPO ( ) 1. 84
RNA 25~31nm 1.34 RNA ph2~9 70% 15 168 ( ) ( ) ( ) CNS CNS CNS PK 1 85
ELISA SMEDI PK (VN) SMEDI ( ) 86
1 SMEDI SPF SPF Talfan SPF 87
2 5 70 80 1981 12 1982 9 4 88
SI SIV SI SIV SIV 9 12 17/17 H1N1 9/17 H3N2 H3N2 H1N1 H3N2 PRCV PRRSV 3. 1980 89
1 H1N1 1984 1 H1N1 32 1 H1N1-27 H1N1 1997) H1N1 2 H3N2 SIV SI SI 20 1 3 90
40 5 1. 91
2. 2.1 2.1.1 6.7.8 6 8 7 10 92
2.1.2 3 5 3 5 12 10 80% 2m/s 93
3 5 2.2 I 94
90% 2.3 2.3.1 95
2.3.2 96
X 2.3.3 28 30 ph 6.9 7.l 4 5 55 15 97
2.3.4 98
2.4 99
3. 3.1 3.2 100
PRRS 101
F-2 102
103
A E B2 11. B1 B2 104
Porcine RotavirUs dis-eaise RV 1943 Woode Bridge1975 1.1 65 75nm 105
11 RNA RV 6 A F MA-104 AGHK CMK 10Ug/m1 ph3 9 60 30min 7 1% 37 3 1% 70% 1% 1.2 1.2.1 1.2.2 1 2 1 2 106
100% 1 4 1 3 7% 15% 50% 1.2.3 1.2.4 24h PAGE 1 1.3 1 10 MA-104 107
3.7% 24 72h 7 7-30 1. 2. 3. 4. 108
1-2 5. E 6. 28% 7. ( ) 109
( ) ( ) 1. 2. 3. (1) 20 60 (2) 60 110
( ) ( ) ( ) ( ) 111
( ) ( ) 1. 30 2. EO-630 1 60 ( ) ( ) 3-12 112
( ) ( ) ( ) 60 2-4 6 ( ) ( ) 20 4 ( ) 113
( ) ( ) 30 ( ) ( ) 3 7 114
( ) 10 2-3 ( ) ( ) 1. 2. 3. 35-40 15-20 ( ) 115
( ) ( ) ( ) 1. 2. 30 15 5 ( ) A O 116
( ) ( ) ( ) ( ) ( ) 117
118
20 25 60 5 7 10 48 1 3 119
50% (1) (2) (3) 120
(4) 1 3 1. 4.5 5-6 2. (1) 121
(2) 3. 4. 26.4% 122
1. 2. 3. 123
(1) (2) (3) 4. (1) (2) (3) 1. 2. 124
3. 3-4 0.5-0.6 4. 5. 1-2 0.25% 6.86% 27 0. 10 6. 0.1% 7. 0.1% AR PM Bb 125
6-8 126
1 2 40 50mg 3 5 50mg 3 5 0.05 0.1 3 5 1 2% 0.1% 127
0.02% 2 12 AR 25 40 2ml 4 8 0.5ml Echinococcosis 100 50% 128
1. 2. 2-3 3. 4. (1) 5 10 129
2540 (2) 1 ( ) 313 265 10-12 39-41 130
1ml 10ml 5 10ml 0.01 0.03ml 4 131
PCV 40% 15% 10-20% 1. 1) 132
80% 125 + 100 80% 125 +12% 2000 + 1000 80% 125 + 500 +TMP100 + 1000 1 1 1 2) 14 80% 190 + 150 +10% 1000 1 100% + 100 1 1 1 ' ' 35-40 2. 80% 100 + 150 150 1 133
1. 1992 4 2 15kg 18 2 16 1 10ml 30% 4ml 120 1 2 70 100 4% 0.25% 1 2 100 1 2 5d 1 20 5% 200ml 5ml C4ml 20 134
2. 2 3. 4. (1) 4d 1 (2) (3) (4) 40 135
3 1. 7 120 1 2-3 2. 2 2 3 40 1 4-6 3. 15 12 25 1 3-5 136
30 6 Porcine respiratory disease complex PRDC 137
PRDC PRRSV PRV SIV PRCV PRDC PRDC 138
PRDC PRRSV M. Hyopneumoniae PRDC PRDC PRDC 139
1. PRDC 2. PRDC 3. 4. PRDC 50ppm + 300ppm 100ppm + 400ppm PRDC 13 17 PRDC 140
1. 1.1 1.2 1.3 1.4 1.5 1.6 2. 2.1 2.2 2.3 2.4-6- 141
3. 24 1 2-3 4. Lmt 3 1 5. 2 1 3 1 6. 1 7. 10 7 1 6 1 142
143
41 42 1 2 1 144
2% 5% 20% 4 25 65 4 15 4 4 2 1 2 35 70 4 145
1. 10 / 2-4 4-5 / 5-10 5-10 8 1 2-3 0 2 / 1 1 2 0.2 / 1 1 3 1 600 / 2 / 400 / 1 2. 146
0.1% E 0.5 10 1 19%-20% 14-18 1. 1.1 21d K88 K99 2 3 1 100 1 3000 1.2 1 2d 2 3d 6 7 1 4000 147
1 2. 2.1 0.1% 0.05% 0.1% 1 2 2.2 0.5 0.125g 3 5ml 2 3 95% 20% 2.3 3.5g 2.5g 1.5g 20g 4g 1000ml 80 100ml 2.4 2 10% 5ml 2.5% B13ml 10% C5ml 1% 2ml 5% 100ml 85ml 39 5ml 148
15 6 15-27 3 TA-53) 4 6 149
1. 1 PBS 1 3-4 5 5 1 1 5 2 150
3-4 2 2. 1 PBS 1 3. 2 0.2% 2 2 4. 2 1 5. - - 3 1 2 151
3 3 1. 2. 1 3. 4. 1. 4 0.2% 2 2. 3. 1 20% 1 6 152
5 4. K88 K99 987B F41 2 K88 K99 1 2 21 21 14 1 5. C 45 15 5 1 2 15 6. 4 2 7 9 153
7. 2 2 3-4 8. -D 1 2 1 9. - - 3 12 3 10. 3 2 1. 20-25 2 154
1 55-60 2 0.2% 2 1 1-1.5 1.5-2 2 20-35 4 2 ) 3 4 1.5-2.0 2 55-60 2 4 2. 60 3. 1 20% 1 60-70 155
4. 1 1 15-25 1.5-2.0cm 16G 1-1.5cm 10 30 5. 1 20% 1 30 30 3-4 9 6. 1 30-35 3-4 3-4 30-35 7. 1 1 30-35 156
7 14 6 8. -D 1 20-30 2-3 9. 2 30 60 1 10. 1 20-30 1. 2. 1 1 3. 4 2 1 157
6 1. 2. 3. 4. 5. 4 6. 158
(PRRS) (PRRSV) PRRS 1987 1995 PRRSV PRRSV 1. PRRSV RNA 55 60nm ORF PRRSV CL-2621 Marc145 Hs*2H PRRSV 159
ph ph 7 5 90% ph5.5 6.6 ph 37 56 45min 2. PRRSV 2 Lelystad virus( LV) A ATCC VR-2332 B PRRSV PRRSV 3 15KD (N) 18KD (M) 25KD (E) N PRRSV 7d N 160
3. PRRSV 90d 4. PRRSV 4.1 1 3 8 12 3 PRRS 8% 161
20% 1 25% PRRS 4.2 4.3 40% 50% 10% PRRS 5. PRRS PRRS 162
PRRSV PRRSV 5.1 PRRS 5.2 5.3 PRRSV (IPMA) (IFA) (NT) (ELISA Dot-ELISA PRRSV A B PRRSV 163
McAb VR2332 McAb SDOWD N McAb PRRSV PAMs CL-2621 Marc-145 PRRSV PRRSV RT-PCR PRRS RT-PCR RT-PCR PCR cdna DNA Nerthern PRRSV RNA PRRSV 164
PRRSV 6. 6.1 PRRSV ( ) 6.2 PRRS PRRS 6.3 PRRS Ab FC FC PRRSV 165
PRRSV PRRS PRRS PRRS PRRSV Ab PRRS 6.4 166
2 1. 167
PRRS 2. 3. 168
4. 30% 5. 169
6. 1. 2. 3. 170
1000 500 4. 171
5. 35 40 6. 7. 3 172
8. 9. 10. 11. 3-6 173
12. 13. 14. 15. 174
3 5 175
1 176
1. 2. 50-100 30-50 3. 2 40-60 12 1 10-20 12 1 1. 177
2. 8 90-100% 3. 4. 5. 1. 2. 3. 2-3 4. 5. 100% 10-20 10-30% 1. 178
43.3 1 3 7 10 1 179
PPV PH PPV PPV PPV 180
PPV PPV PPV PPV PPV PPV PPV PPV PPV PPV PPV 181
9 PPV SMEDI SMEDI 182
183
1-2 184
30 40 35-40 30 40 4 PRRS 1987 185
1991 2-5 30-50% 1-3 186
1-2 PRRS 50% 50% 187
1. 2. 3. 1-2 4. 95% 188
5. 6. 7. 1. -15 2-15 2 2-8 9 2. 189
2-8 3. 2-8 4. 2-8 1. 1999-2002 IDEXX 1116 175 15.68% 10-20 40-60 190
(1) 3 / 3 / 20-25 60-65 2 / (2) 3 / 3 / 20 30 3 / ( ) 1 / 1-2 35-40 2 / (3) 5-8 / 3-5 191
7-10 2. 1999-2002 IDEXX 596 6247 2008 (ge) 32.2% 14-16 9-10 ge ge (1) 192
3-4 2 / 1 2 / 1 1 / (2) 3-4 2 / 1 2 / 20 30 2 / 0.5 / 35-40 1 / 3. C D E L R S T C D E R (ST171 ) C 193
4. 15 ( 3-4 ) 5. 15 6. (K88 K99 987P F41) (K88 K99 987P ) (K88 K99) 4 5-6 2-3 7. (TGE) (PED) (RV) 194
4 8. A B D A (EO630 ) A ( ) 9. ( ) 1. 2. 15 4 15-25 2 25 1 3. 195
4. 5. 3 7-10 5 6. 7. 8. ( ) 196
10 ( ) (SA215 ) 197
/ &34 &34 ( Serpulina hyody senteriae ) (Serpulina pilosicoli) Spilosicoli &34 Anguillina coli &34 &34 Serpulin a coli &34 &34 &34 &34 &34 (PIS) &34 198
&34 &34 PIS (P43/6/78) Spilosicoli PIS &34 &34 PIS PIS PIS (Serpullina pilosicoli &34 &34 ) (Serpulina) 199
(6 10 m ) (0 25 0 30 m ) ( 4 7 ) 6 ( ) (Sinnocens) (Spilosicoli) (Sintennedia) Serpulina murdochii 4 Smurdochii 200
&34 PIS / SPF 5%(Atyeo 1996c) 37 5% 8 6 11 1 201
PIS PIS PIS Smurdochii P43/6/78 202
PIS PIS 2 7 20 ( ) 203
(Sacco 1996) (33%) ( ) 204
205