1000016 h t t p : / / w w w. k n s i. c o m. t w 248 30 (02)2299-9006 (02)2299-9110. 100 KANG SI 第一期 vol.1 P.1 P.4 P.7 P.8 99 99 99 ( ) -- ATP 1
a P 700 P 680 a a Pq cytochrome Pc Fd H + ATP 酶 ATP ATP a a ATP H 2 OCO 2 H 2 O CO 2 CO 2 CO 2 CO 2 RuBP carboxylase 2
ATP NADPH ATPADP Pi coupled reaction? ATP ATP ATP ATP 10 10 ATP ATP ATP 4ADPATP ATP ADP7.3 ATP ATP ADP Pi NADP + NADPH H + e - NADP + NADPH NADP + + 2e - + H + NADPH NADP + + 2e - + 2H + NADPH + H + H ATP NADP + ATP ATP ATP ADP ATPATP 3
1. iest Administrator http://www.iest.cc/biophy/index. php?option=com_content&task=view&id=32&item id=29 2. 3. 4. http://solarpv.itri.org.tw/aboutus/sense/principle.asp 5. http://www.tfci.org.tw/fc/index.asp 6. 7. http://zh.wikipedia.org/zh-tw/ File:NADP%2B_phys_alt.svg http://zh.wikipedia. org/zh-tw/file:nadph_phys_alt.svg 8. 1. 2. 3. 4. 5. www.bbioo.com ( ) P.6 2010 12 1 Prion ( ) kuru 1966Gajdusek "kuria guria" Prion1997Stanley Prusiner TSE BSECJD Prion disease ( ) PrP Prion Protein 4
PrPPrP C Cellular PrP PrP PrP C - PrP SC SC - PrP SC PrP SC 1000 PrP SC ( ) PrP SC PrP SC PrP SC PrP SC BPrP SC PrP SC PrP SC PrP C PrP SC PrP SC PrP SC PrP SC CJD 1920 6~12 nv-cjd CJD SEAC 1996 nv-cjd CJD 0.5~1 12~5228 63 13 6 14 4 BSE TSE BSEnv-CJD nv-cjd nv-cjd 5
BSE nv-cjd BSE 1 2 nv-cjd PrP SC PrP PrP SC PrP SC Pratice ( A B C D E ) 1. ( ) (A)(B)(C) (D)(E) ( B E ) 2. ( ) (A) 1000(B) Prion (C)Prion (D) Prion (E) Prion ( A C D ) 3. ( ) (A) (B) (C) (D)PrP SC (E) 1. " " " "(A)(B)(C)(D)(E) 2. (B) " PrP SC... PrP SC "(E) 3. "PrP SC PrP SC... PrP SC " (A) (C)(D) Prion(A)(C)(D) 1. proteinaceous infectious particle 2. transmissible spongiform encephalopathy, TSE 3. Bovine Spongiform Encephalopathy BSE 4. scrapie 5. Creuzfeldt-Jacob disease CJD 6. spongiform encephalopathy 7. Follicular dendritic cells 8. quinacrine 9. chlorpromazinev 6
1. http://tw.news.yahoo.com/article/url/d/a/101208/5/2imti.html2010/12/08 2. http://www.kmuh.org.tw/www/kmcj/data/9302/14.htm 3. prion http://140.121.155.217/seminar/m91320047-1.pdf 4. Prions Protein (scrapie prion protein, PrPsc) http://tw.myblog.yahoo.com/jingyingwu-jack/article?mid=4 7&prev=275&next=2&l 5. (Prion) http://beaver.dlc.ncnu.edu.tw/projects/emag/article/200311/.pdf 6. ( Prion ) http://ortho.clmed.ncku.edu.tw/~cjlin/othernote/nobelstory.html 7. Prion http://www.shs.edu.tw/works/essay/2006/04/2006041012170383.pdf 8. http://zh.wikipedia.org/zh-tw/%e5%ba%93%e9%b2%81%e7%97%85 9. (sciscape.org) http://www.sciscape.org/smf/index.php?topic=13245 10. Kuruhttp://www.wretch.cc/blog/chopnight/13743549 11. ( Prion) http://highscope.ch.ntu.edu.tw/wordpress/?p=7995 12. 13. 30 ( 12 ) 375-376 http://www.cgmh.org.tw/cgmn/cgmn_file/0912012.pdf 14. Creutzfeldt-Jacob disease, CJD kuru) http://mulicia.pixnet.net/blog/post/20976753 15. http://thubioinfo.twbbs.org/?p=207 16. http://www.cdc.gov.tw/sp.asp?xdurl=disease/disease_content.asp&id=1689&mp=1&ctnode=1498 ( )( ) Parkinson's disease L-Dopa Agonist parkin protein parkin protein parkin protein 0-60 0 20 60 120 180 240 300 360 420 480 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +++ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 7
( C ) 1. (A) (B) (C) (D) (ABC) 2. ( ) (A) (B) (C) (D)parkin protein (E) ( B ) 3. ( C (A) (B) (C) (D) ) 4. (A) (B) (C) (D) 1. 2. (D) parkin protein (E) 3. 120~420 300 4. 2 4/29~4/30 ~3/31 http://www.bird.org.tw/index. php?block=main.php 1/10~4/30 1/10~4/30 http://211.72.198.83/ngis/ 4/9~10/15 ~3/21 1. 18 2. http://www.sow.org.tw/index.do 3D ~3/6 ~3/6 http://cal.nmns.edu.tw/ NMNS_Cal/Detail_Ann. aspx?anid=3302 8