Shanghai Haohai Biological Technology Co., Ltd.* 6826 663.92 28.7% 2014 87.2% 84.2% 273.47 49.0% 1.86 1.53 0.40 64,018,120 1
4 663,917 515,940 (105,073) (65,883) 558,844 450,057 4 98,744 30,764 (242,100) (187,191) (58,878) (48,960) (35,254) (26,460) (979) (2,594) 270 320,647 215,616 5 (47,341) (32,034) 273,306 183,582 273,474 183,582 (168) 273,306 183,582 7 1.86 1.53 2
396,595 352,003 31,626 32,364 3,262 4,050 11,202 4,359 5,453 2,812 10,678 449,856 404,548 78,063 76,364 8 91,287 62,443 2,752 24,917 18,609 5,846 2,177,787 181,341 2,372,054 347,355 9 4,794 8,790 112,272 125,483 23,927 4,966 140,993 139,239 3
2,231,061 208,116 2,680,917 612,664 620 761 14,863 17,743 15,483 18,504 2,665,434 594,160 160,045 120,000 2,501,866 474,160 2,661,911 594,160 3,523 2,665,434 594,160 4
1. 5 % % 160,000,000 100 100 15,000,000 HA 100 150,000,000 60 (1) 10,000,000 5
% % (2) 100 100 (1) 6,000,000 60% (2) 2.1 (a) (b) (c) 6
(i) (ii) (iii) (i) (ii) (iii) 2.2 19 622 7
2.3 9 3 10 28 5 10 1 12 28 11 1 14 6 15 3 16 4 1 1 16 1 38 16 1 41 27 1 12 2 7 2 1 1 2 3 4 5 6 9 39 9 9 8
15 15 15 15 15 15 1 (i) 1 (ii) (iii) (iv) 9
3. 99% 99% 8 5% 4. 663,917 515,940 38,319 3,703 i) 30,062 25,664 353 28,747 1 1,616 1,043 98,744 30,764 i) 10
5. 15% 25% 16.5% 46,051 33,276 337 262 953 (1,504) 47,341 32,034 6. 0.40 64,018 0.40 64,018,120 7. 146,985,960 120,000,000 11
273,306 183,582 146,985,960 120,000,000 8. 811 96,007 64,908 (4,720) (3,276) 91,287 62,443 3 77,609 52,132 3 6 13,535 11,056 6 1 4,590 2,340 1 2 265 184 2 3 8 7 96,007 65,719 12
1 1 3,276 2,120 1,478 1,156 (34) 4,720 3,276 57,000 40,000 273,000 191,000 2,557,000 4,800,000 13
9. 4,794 2,944 5,846 4,794 8,790 3 4,745 8,671 3 1 49 72 1 47 4,794 8,790 30 90 14
14 3 CFDA 2 1 11 CFDA 15
(rhegf) 31.7% 15.3% 16
OVD OVD OVD 41.80% 48.0% 7 7 70 17
GMP GMP GMP 663.92 147.98 28.7% 19.9% 115.3% 8.1% 15.3% 284.05 122.34 72.40 179.00 6.12 18
% % 284,049 42.8% 236,838 45.9% 122,343 18.4% 56,819 11.1% 72,403 10.9% 66,980 13.0% 178,999 27.0% 155,303 30.0% 6,123 0.9% 663,917 100.0% 515,940 100.0% 273.47 183.58 89.89 49.0% 24.43 35.7% 1.86 1.53 87.2% 84.2% 12 19
% % 227,785 34.3% 206,624 40.0% 56,264 8.5% 26,630 5.2% 3,584 0.7% 284,049 42.8% 236,838 45.9% 284.05 236.84 47.21 19.9% 21.16 29.63 227.79 10.2% 20
56.26 111.3% % % 87,255 13.1% 25,571 5.0% 35,088 5.3% 31,248 6.1% 122,343 18.4% 56,819 11.1% 21
122.34 56.82 65.52 115.3% CFDA 87.26 241.2% 22
QST 23
15.3% % % 71,032 10.7% 66,963 13.0% 1,371 0.2% 17 0.0% 72,403 10.9% 66,980 13.0% OVD 72.40 66.98 5.42 8.1% OVD OVD 41.8% OVD OVD CFDA 24
% % 108,914 16.4% 93,780 18.1% 60,303 9.1% 52,194 10.1% 9,782 1.5% 9,328 1.8% 178,999 27.0% 155,302 30.0% 48.0% 179.00 155.30 23.70 15.3% ( ) 25
B 114 95 7 30 26
18 1 2 4 11 QST 2016 II 2016 QST 2017 27
2017 2018 863 863 4 9 28
29
1,300 518.26 78.1% 145.66 21.9% 30
[2015]34 [2015]3095 31
32
33
663.92 515.94 147.98 28.7% 65.88 105.07 39.19 87.2% 84.2% 34
187.19 242.10 54.91 36.3% 36.5% 48.96 58.88 9.92 9.5% 8.9% 26.46 35.25 8.79 5.3% 5.1% 32.03 47.34 15.31 14.8%14.9% 35
183.58 273.47 89.89 49.0% 24.43 35.7% 1.86 1.53 2,372.05 2,024.69 140.99 1.75 16.82 2.49 268.51 141.99 126.52 149.25 88.15 61.10 1,754.57 70.32 1,824.89 H 40,045,300 1.00 59.00 2,362.67 69.42 1,794.28 40.05 1,754.23 36
6 60% 38% 37
549 222 114 140 10 63 549 GMP 85.31 38
156.48 5.55% 20.98% 1,794.28 (a) 02138 10,000,000 (b) 0.40 64,018,120 39
H 0.40 64,018,120 H H H H H H H H 183 17 1712-1716 H 139 2 4 40
H H 183 17 1712-1716 H 139 2 4 41
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