I 做大做强，走仿制型创新

2002 1 2002 5 WWW.CEI.GOV.CN 2 10 111 : : WTO : TEL 01068558557 1 FAX 01068558370

---- I...2...2...3 II...3 1993 2011 2...3...8 III2002 1...10 IV 2001...19 V...28...29...31 2001...40 2001...44 TEL 01068558557 2 FAX 01068558370

---- I WTO TRIPS TRIPS 26 97 1993 TRIPS WTO 500 4 10 500 2001 5 2001 2499 2000 11.2 TEL 01068558557 2 FAX 01068558370

---- 2000 16 2005 50 Bolar II 1993 2011 2 20 80 Scrip Magazine 1996 Pharmaprojects 199 20 80 1995 16 TEL 01068558557 3 FAX 01068558370

---- 10000 16 1993 1 1 7 6 111 1993 2011 111 2 60 111 1 2 3 4 5 6 7 8 9 10 Diclorenac / Ciba-geigy 11.407 (1993) Naproxen / Syntex 7.120 (1993) Atenolol Zeneca 4.71(2000) 7.006(1993) Alprazolam 6.240 Upjohn (1993) Gemfibrozil Warneram-bert 5.01(1993) 1993 Metoprolol Ciba-geigy 5.77(2000) 5.317(1999) Etoposide Bristolyers squibb Levonorgestr el Dobutamime Naproxensod ium 1993 1993 50 58 1993 14 1993 17 1993 Wyety-ayerst 2.590(1993) 1993 Eli lilly 2.300(1993) 1993 / Syntex Elan 2.155(1993) 1993 4 2.900(1993) 1993 4 6 TEL 01068558557 4 FAX 01068558370

---- 11 12 13 14 15 16 17 18 19 20 21 Cimetidine Smith Kline beecham Terfenadine Marion merrell dow 10.095(1993) 1994 7.470(1993) 1994 Diltiazem Marion merrell dow 5.680(1993) 1994 Glyburide Hoechst-roussel 13.381(1993) 1994 Lorazepam Wyeth-ayerst 3.303(1993) 1994 88 Glyburide,H Wpjohn B-419 2.830(1993) 1994 30 Glipizide Pfizer 2.360(1993) 1994 Captopril Bristolyers squibb 14.700(1993) 1995 59 Cyclosporins Cefotaxime Sandoz 8.966(1993) 1996 Hoechst-roussel 13.769(1993) 1996 26 Leuprorelin TAP 3.500(1993) 1996 Bristolyers 22 Iopamidol 3.100(1993) 1996 squibb 23 Disoprofol Zeneca 3.080(1993) 1996 24 25 26 Aciclovir Wellcome 11.628(1993) 1997 Iohexol Sanofi winthrop 5.053(1993) 1997 Pentoxifyllin e Hoechst-roussel 13.956(1993) 1997 21 TEL 01068558557 5 FAX 01068558370

---- 27 28 29 30 31 32 33 Timolol Merck 3.700(1993) 1997 Etodolac Syntex 3.224(1993) 1997 Etodolac Wyethyerst 2.575(1993) 1997 Paroxetine Smith Kline beecham 13.780(1999) 1997 Goserelin Zeneca 2.280(1993) 1997 Loratadine Schering- plough 2004. 10.000(2000) 4.21 Lovastatin, mevacor Merck 13.100(1993)4 5(2001) 2001. 6.15 11 34 35 36 37 38 39 Beclomehaso ne Beclovent Lipitor Glaxo 5.555(1993) 1999 8 Pfizer 61.8(2001) Lescol Novartis 4.283(2000) 1997 2009.9 2011. 11 Provastatin, Bristolyers 19.00(2001) 2005. provachcol squibb 6.050(1993) 10.20 Ceftazidime Glaxo 4.717(1993) 1999 Ketoconazol e Janssen 3.250(1993) 1999 10 40 41 Sulbactam Pfizer 3.050(1993) 1999 Midazolam Hoffmann-la Roche 3.782(1999) 2002.4. 15 7 47.2 18.5 15.1 42 Astemizole Janssen 2.500(1993) 1999 TEL 01068558557 6 FAX 01068558370

---- 43 44 45 46 47 48 49 50 Doxazosin Pfizer 3.133(1999) 2000 Clonazepam Hoffmann-la Roche 2.436(1993) 1999 Buspirone Beclometaso ne,beconase Enalapril Amoxicillin/ clavulanic acid Ceftriaxone Famotidine, pepcid Bristol-myers squibb 2.400(1993) 1999 Glaxo 3.302(1993) 1999 Merck 20.650(1993) 2000 3 Smith Kline Beecham Hoffmann-la Roche 18.530(2000) 2002 8.917(1993) 10.12(2000) Merck 7.350(1993) 2000 2000.10.17 24 42 9 10 6 Astra Zeneca Prilosec,omeprazole 2001 4 FDA 2001 10 2000 59.1 Astra Zeneca Nexium Cesomepraxole S- 4 2003 35 TEL 01068558557 7 FAX 01068558370

---- 89 2002 3 DCL 2004 DCL H 1 DCL 2014 1986 1993 1 1 40 7 2001 3000 2000 2001 112 127 50 10 10 TEL 01068558557 8 FAX 01068558370

---- Lipitor,atorvastatin Celebrex (Xenical,orlistat) Nexium(esomeprazole) Auamdia rosiglitazone Zanamivir,Relanza Gilead Tamiflu(oseltamivir) Biocrys/ RWJ27021 7 Eisai/ Aricept(donepezil),Shire/Janssen cilog galantamine,reminylcox-2 Celebrex merck Vioxx(rofecoxib) / ZD4522rosuvastatin 2002 Zelmac(tegaserod), 2001 loytonex(alosetran) zantacbms Vanlev(omapatrilat) FDA 2002 2003 7.5 30 Genentech Avastin / 20022003 20 Astra Zeneca Crestor(rosuvastatin Ca) FDA HMGCoA 4 23 Arentis SA Pfizer Exubera 20022003 FDA 20 Pfizer Boehringer Ingelheim Spiriva(tiotropium bromide) 10 TEL 01068558557 9 FAX 01068558370

---- III 2002 1 2001 4 2002 1 126 2001 4 2002 1 1 NFX20011096 X20020110 2 NFX20011398 X20020109 3 NFX20010515 X20020112 4 NFX20010514 X20020111 5 NFX20011551 X20020118 6 NFX20011548 X20020058 7 NFX20011549 X20020059 8 NFX20011550 X20020119 9 NFX20011553 X20020117 10 NFX20011554 X20020116 TEL 01068558557 10 FAX 01068558370

---- 11 NFX20011555 X20020114 12 NFX20011556 X20020115 13 NFX20011557 X20020113 14 NFX20011576 X20020101 15 NFX20011651 X20020108 16 NFX20011557 X20020113 17 NFX20011556 X20020115 18 NFX20020010 X20020099 19 NFX20020011 X20020098 20 NFX20020024 X20020091 21 NFX20020012 X20020097 22 NFX20020013 X20020096 23 NFX20020014 X20020095 24 NFX20020015 X20020061 TEL 01068558557 11 FAX 01068558370

---- 25 NFX20020016 X20020062 26 NFX20020017 MG 3 X20020063 27 NFX20020018 X20020094 28 NFX20020022 X20020093 29 NFX20020023 X20020092 30 NFX20020029 X20020090 31 NFX20020030 X20020089 32 NFX20020031 X20020088 33 NFX20020032 X20020087 34 NFX20020033 X20020086 35 NFX20020034 X20020085 36 NFX20020035 X20020084 37 NFX20020037 X20020082 38 NFX20020038 X20020081 39 NFX20020039 X20020080 TEL 01068558557 12 FAX 01068558370

---- 40 NFX20020040 X20020079 41 NFX20020041 42 NFX20020042 X20020078 18AA 40 X20020077 43 NFX20020043 X20020076 44 NFX20020044 X20020075 45 NFX20020045 X20020074 46 NFX20020046 X20020073 47 NFX20020047 X20020072 48 NFX20020048 X20020071 49 NFX20020049 X20020070 50 NFX20020050 X20020069 51 NFX20020051 X20020068 52 NFX20020054 X20020067 53 NFX20020055 X20020066 54 NFX20020006 X20020060 TEL 01068558557 13 FAX 01068558370

---- 55 NFX20011575 X20020102 56 NFX20020005 X20020100 57 NFX20011565 X20020053 58 NFX20000147 X20000301 59 NFX20000691 X20010064 60 NFX20011125 X20011408 61 NFX20011126 X20011407 62 NFX20011127 X20011410 63 NFX20011128 X20011406 64 NFX20011148 X20011412 65 NFX20011149 X20011411 66 NFX20011195 X20011405 67 NFX20011169 X20011417 68 NFX20011167 X20011415 69 NFX20011168 X20011416 TEL 01068558557 14 FAX 01068558370

---- 70 NFX20011308 X20020043 71 NFX20000621 X20011516 72 NFX20011384 X20011485 73 NFX20011397 X20011395 74 NFX20011399 X20011394 75 NFX20011401 X20011393 76 NFX20011403 X20011486 77 NFX20011404 X20011392 78 NFX20011405 X20011391 79 NFX20011406 X20011390 80 NFX20011407 X20011403 81 NFX20011412 X20020041 82 NFX20011419 X20011420 83 NFX20011420 X20011385 84 NFX20011426 X20011382 TEL 01068558557 15 FAX 01068558370

---- 17AA 85 NFX20011427 40 X20011381 86 NFX20011428 X20011380 87 NFX20011429 X20011379 88 NFX20011430 X20011378 89 NFX20011431 X20011377 90 NFX20011432 X20011376 91 NFX20011433 X20011375 92 NFX20011440 X20011436 93 NFX20011441 X20011440 94 NFX20011444 X20011483 95 NFX20011445 X20011441 96 NFX20011446 X20011442 97 NFX20011447 X20011443 98 NFX20011448 X20011444 99 NFX20011449 X20011445 100 NFX20011451 20 X20011447 TEL 01068558557 16 FAX 01068558370

---- 101 NFX20011452 102 NFX20011450 40 X20011474 40 X20011446 103 NFX20011474 A X20011449 104 NFX20011475 A X20011450 105 NFX20011457 X20011475 106 NFX20011458 X20011472 107 NFX20011462 X20011461 108 NFX20011463 X20011462 109 NFX20011464 X20011463 110 NFX20011465 X20011464 111 NFX20011466 X20011465 112 NFX20011473 X20011466 113 NFX20011482 X20011496 114 NFX20011489 X20011489 TEL 01068558557 17 FAX 01068558370

---- 115 NFX20011490 X20011490 116 NFX20011492 117 NFX20011193 118 NFX20011494 70 X20011468 70 X20011469 X20011470 119 NFX20011495 X20011471 120 NFX20011510 X20020015 121 NFX20011511 X20020007 122 NFX20011477 X20011526 123 NFX20011478 X20020012 124 NFX20011513 X20020002 125 NFX20011131 X20011409 126 NFX20011166 X20011414 TEL 01068558557 18 FAX 01068558370

---- IV 2001 2000 9 2001 12 2001 247 1 2 7-3 4 5 6 7 8 9 10 11 12 99mTC 13 14 15 16 153SM 17 C 1 18 13C 19 13C 75mg/ 20 21 1. TEL 01068558557 19 FAX 01068558370

---- 2 22 3 23 24 25 26 27 28 29 4 30 31 32 33 34 35 36 37 38 39 40 41 42 5 43 + 44 45 46 47 48 49 50 2. 3. 4 5 TEL 01068558557 20 FAX 01068558370

---- 51 52 53 L 6 54 55 56 57 58 59 60 61 62 63 64 65 A 66 67 68 69 70 71 72 / 17 73 74 75 76 77 78 79 80 L 81 L 6 TEL 01068558557 21 FAX 01068558370

---- 82 83 84 99m TC 85 86 87 88 89 90 91 + 92 93 94 95 d1-96 97 98 99 100 101 102 103 104 105 106 107 TEL 01068558557 22 FAX 01068558370

---- 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 L- 137 138 C C 139 TEL 01068558557 23 FAX 01068558370

---- 140 141 142 143 144 145 146 17AA-H L- L- L- L- L- L- L- L- L- L- L- L- L- L- L- 147 D 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 TEL 01068558557 24 FAX 01068558370

---- 167 200/0.5 168 169 170 171 172 173 174 175 176 177 178 179 180 - DL-3- -Z - 4- -2-2 - 3--2-- DL-2- -4- - L- L- L- L- 181 182 183 184 185 186 187 188 189 190 191 1 192 193 194 195 196 TEL 01068558557 25 FAX 01068558370

---- 197 198 199 200 201 202 203 204 205 206 207 7 208 + 209 210 L- L- L- L- L- L- L- L- L- L- L- L- L- 8 211 + 212 1 213 214 215 Nateglinide 216 217 218 Gatifloxacin 219 Docetaxel 220 221 222 223 1112 9 224 7 8 TEL 01068558557 26 FAX 01068558370

---- 225 + 226 227 10 228 + 229 230 231 232 233 234 B 12 235 236 237 238 239 240 241 242 243 244 245 246 247 9 10 TEL 01068558557 27 FAX 01068558370

---- V 2002 2002 463 321 298 124.42%118.85% 117.15% 6.73 114.9% 37.4 2.64 115.41%102.32% 2001 2002 2001 2002 2001 2002 +7.2% +10.9% +7.5% +10.3% +17.2% +9.8% +22.4% -4.4% +5.2% +12.0% +10.0% +7.7% +13.0% +6.8% +8.5% +22.4% +13.8% +10.8% +1.1% 2002 2001 2001 2002 60% 42.6% 4% 22.7% 30% 8.1% 14.7% 4.1% 8.5%2002 2001 11%2002 30%70% 10% 3000 4000 1.2 1.68 3 TEL 01068558557 28 FAX 01068558370

---- 1.2002 2001 44% 39.2% 50% 48% 41% 2. 1 10 1 +1374 % 6 +170% 2 V +669% 7 +127% 3 +287% 8 +93% 4 +230% 9 +90% 5 +173% 10 +56% 14 18% 1085 300 150 50 1000 360 75 70% 2 140%256% 50%30% 3 SN 50% SMZ 22% SM2 33.5%23% 4 23% 30% TEL 01068558557 29 FAX 01068558370

---- 5 VB2 Vc VB1 VB1 12% 39% 6 26% 57% 6APA 83% 750 C 45 3. 2002 1.1 27.8 8.4 129 11 () 65.41% 18.92%50.53%11.26%26.82% 56 671 1.3 14.26%11.18%30.91% 1 1 +471.0% 7 +49.0% - +15.6% 8 +40.5% 2 +258.0% 9 +39.0% 3 -+220.0% 10 +27.0% 4 +151.5% +7.5% 5 +109.0% +589.0% 6 +76.0% 25.3 12.9 18 4.7 3.3 1.4 0.56 0.53 0.29 2 64.4% 5.35 4.2% 4.2 2.16 0.1152 3 TEL 01068558557 30 FAX 01068558370

---- 7300 1.6 8.2 720 1800 4 430% 140% 25% 56% 5 148% 8 1% 6.3% 7.7 3 6 5.7% 10% NaCl 81.7%128% 92.5% 27%44.6% 58%0.4%60%43% 1. 2001 2.8% 36.4%2002 34.6% 1% 1 2001 2001 15.8%7.8%5.5%5.2% 4% <1>1000 () ( ) 241842 17591 Vc 39027 15371 27300 7570 21516 4947 18000 11477 VE 10167 7018 7595 3011 6773 1233 TEL 01068558557 31 FAX 01068558370

---- 5764 3021 3151 444 2845 1998 2397 1289 1913 1330 VB1 1817 2203 VA 1560 2298 1500 1339 1481 2871 1465 669 1350 2512 <2>1000 VB2(874 1709 ) VB6(887 1506 )VB12(2221 ) (4755 ) (1770 ) (1137 ) (2600 ) (1093 ) (2929 ) (4459 ) 1 41 81 2 42 82 3 43 83 4 44 84 5 45 85 6 46 86 7 47 87 8 48 88 9 49 89 10 50 90 11 51 91 12 52 92 13 53 93 14 54 94 15 55 95 TEL 01068558557 32 FAX 01068558370

---- 16 56 96 17 57 97 18 58 98 19 59 99 20 60 100 21 61 101 22 62 102 23 63 103 24 64 104 25 65 105 26 66 106 27 67 107 28 68 108 29 69 109 30 70 110 31 71 111 32 72 112 33 73 113-34 74 114 35 75 115 36 76 116 37 77 117 38 78 118 39 79 119 40 80 120 1999 4 20% 14% 6.3 6.5% 5 5.5% 4 45% 510 10 66% 2002 2001 29%17%21%23% 3% 1% 3.35% TEL 01068558557 33 FAX 01068558370

---- 2001 2002 0.760 / 0.148 / 0.180 / SM2 VA VB2 VB6 Vc VE 0.570 / 1.550 / 2.000 / 1.870 / 0.510 / 0.810 / 0.510 / 0.070 / 0.230 / 0.400 / 0.520 / 0.129 / 0.170 / 0.510 / 1.320 / 1.870 / 1.690 / 0.300 / 0.630 / 0.490 / 0.068 / 0.226 / 0.390 / 1 56364925 62 367658 2 41377032 63 362623 3 18126162 64 343572 4 17986562 65 313194 5 13621467 66 312698 6 12233709 67 304326 7 10896325 68 274416 8 9910195 69 230720 9 8035883 70 219877 10 7191652 71 204388 11 6568257 72 203379 12 5915783 73 169518 13 5863681 74 164189 14 5773491 75 163225 15 5548531 76 158110 16 4938194 77 153271 TEL 01068558557 34 FAX 01068558370

---- 17 4912939 78 120556 18 4280369 79 108822 19 4230227 80 102640 20 3817165 81 101366 21 3624344 82 93553 22 2786143 83 84359 23 2784018 84 82369 24 2684572 85 80490 25 2517823 86 80480 26 2212072 87 75703 27 2202636 88 73640 28 2099980 89 66581 29 2050391 90 64251 30 2002551 91 62241 31 1864904 92 61268 32 1820106 93 57946 33 1667699 94 54505 34 1540856 95 48508 35 1463613 96 47189 36 1434850 97 46251 37 1278298 98 44230 38 1112941 99 36235 39 1000728 100 34223 40 994208 101 27130 41 940867 102 25200 42 876875 103 22800 43 871470 104 21399 44 838965 105 20250 45 748137 106 17785 46 730038 107 17000 47 700075 108 14637 48 630612 109 12950 49 627863 110 12484 50 618288 111 11951 51 577318 112 10500 52 574833 113 9621 53 515719 114 8758 TEL 01068558557 35 FAX 01068558370

---- 54 506257 115 8611 55 493896 116 2220 56 480857 117 1642 57 456305 118 1550 58 452212 119 893 59 431442 120 808 60 414038 121 570 61 383337 305681274 2002 2001 5 1112 109 10 9 11 15 2 2001 2001 9720 9344 2001 (%) +454%(2001 460 ) +237%(2001 40 ) +259%(2001 45 ) +105% 7ACA7ADCA ( ) +53% +85% +70%(2001 1050 ) 2002 2001 2002 2772 2243 2002 2001 V 104 15.0 7ACA 7ADCA 2123 1602.0 1254 563.0 5 324 41.0 6 304 22.8 TEL 01068558557 36 FAX 01068558370

---- 220 223 81 291 170.0 56.0 142.0 207.0 895 910.0 473 430 422.0 315.0 2.2001 2001 109.7 23.05 21% 1997 1997 40.3% 1998 33.0% 1999 26.8% 2000 22.9% 2001 21.0% 2000 568 221 () () () (%) 2006 568 221 21.00 1 34 18 9 82.60 2 99 37 29 46.30 3 131 28 9 33.00 4 163 65 20 30.35 5 220 50 18 24.60 6-94 34 16 24.00 7 54 17 9 23.40 8 320 86 33 23.12 9 96 40 16 20.00 10 207 70 21 16.90 TEL 01068558557 37 FAX 01068558370

---- 11 168 66 17 15.54 12 137 24 10 15.00 13 135 33 9 12.00 1000 66 ( ) 1 8949 2 8915 3 6250 4 5634 5 5392 6 3729 7 3569 8 3422 9 3380 10 3277 11 3195 12 3155 13 3127 14 2855 15 / 2775 16 2697 17 2617 18 / 2458 19 ( ) 2441 20 2275 21 2265 22 2265 23 2170 24 2028 25 2019 26 2009 27 2001 28 1976 TEL 01068558557 38 FAX 01068558370

---- 29 1922 30 1909 31 1901 32 1895 33 1831 34 1806 35 1792 36 1753 37 1715 38 1684 39 1683 40 1682 41 1441 42 1439 43 1426 44 1394 45 1389 46 1386 47-1341 48 1266 49 1255 50 1210 51 1192 52 1189 53 1172 54 1152 55 / 1150 56 1147 57 1136 58 1105 59 1087 60 / 1072 61 1063 62 / 1063 63 1054 64 1054 65 1015 TEL 01068558557 39 FAX 01068558370

---- 66 1013 12 11 8 4 3 2001 1. () B B () () 949 65 327 273 77 220 170 57 59 488 207 331 191 2211 b B 2. 1 ( ) () 1 36 2 32 3 28 4 24 24 5 23 6 19 19 7 18 8 17 9 14 14 10 11 TEL 01068558557 40 FAX 01068558370

---- 11 10 10 10 2 () (41 ) 242 36 32 28 23 14 11 9 7 / 7 6 5 (7 ) 55 17 10 8 5 4 3 (3 ) 28 24 3 1 (11 ) 19 5 3 2 2 25.50% 5.80% 3.00% 2.00% (5 ) 28 3.00% TEL 01068558557 41 FAX 01068558370

---- 24 1 1 1 1 (3 ) 6 4 1 1 0.06% (2 ) 10 8 2 1.05% 3 41 31 7.6% 4 157 79 16.5%8.3% 80 5 25.5 11.3 9.2 8.4 6 18 47 76 7 8 6 8 5 9 4 7 () TEL 01068558557 42 FAX 01068558370

---- 4 8 4 7 3 4 ( ) 20 34 52 () 7 7 5 10 3. () 1 30 2 27 3 18 18 5 / 14 14 7 10 8 7 488 62 12.7% 162 33.2% 4. 1 61 35.9% 2 27 15.9% 3 15 9% 4 23 13.5% TEL 01068558557 43 FAX 01068558370

---- 5 ( )13 7.6% 2001 1. 1 1999 2000 2001 1999 2000 2001 30% 30% 35% 43% 47% 43% 27% 23% 22% 40% 30% 10% 20% 150 50% 150 40% 11% 35% 54% 2 14 2001 2000 7.43% 1999 2000 2001 2000-1999 2000 2001 1999 2000 2001 9.45 19.47 7.43 16.99 23.56 16.73-13.31 1.67 39.77 TEL 01068558557 44 FAX 01068558370

---- 0.05-16.37-24.73-0.05 83.66-39.61 20.83 21.75 4.66 40.51 41.58 59.83 19.00 20.95 8.89 5.31 17.15 12.47 13.05 13.96 15.99 20.22 6.58 12.45 13.16 20.72 2.67 13.11 21.34 15.01 34.50 10.96 18.79 3.07 1.32-1.50 12.60 18.25 14.70 4.26 16.00 13.61 3.29 11.72 11.04 16.74 23.40 16.08 27.11 0.81-8.01 1.30 6.26 0.96 17.51-5.47 31.43-8.42 19.34 21.57 11.00 27.00 0.72 0.85-2.88-19.60 0.88 15.28 13.50 6.49 31.93-13.76 25.45 45.03 3.20 3 (%) (%) 2000 2001 2000 2001 58.00 58.500 12.70 12.890 37.60 37.500 18.30 17.700 1.73 1.670 27.30 27.600 0.90 0.750 22.20 23.280 0.64 0.580 12.80 11.820 TEL 01068558557 45 FAX 01068558370

---- 0.36 0.355 2.55 2.500 0.26 0.146 1.34 1.270 0.20 0.220 0.79 0.870 0.14 0.117 0.58 0.720 0.11 0.120 0.35 0.313 2001 2000 2001 2000 2. 100 1 100 100 112 8.9% 31.3% 38.4% ( ) 21.4%(24 ) 2 (51) (66) (72) (76) (80) (82) (84) (85) (90) (98) 100 (188) (2814) (3215) (3917) (5825) (6735) (5439) (7545) (8846) (7949) (9759) (8265) (9370) (10074)14 (1527) (1031) (1943) (3047) (3448) (2553) (4891) D(6592) (8097) (7899) 10 (1) (2) (3) (6) (11) (13) / (22) (42) TEL 01068558557 46 FAX 01068558370

---- (50) (56) 50 100 50 G 100 3 21 21 26% % % 1-12.35 +24.00 2-6.60 +4.20 3 +33.00 +70.00 4 +23.72 +20.00 5 / +34.41 +15.00 6 +21.12 +54.00 7-27.00-11.00 8 +38.51 +34.00 9 +18.85 +40.00 10-0.24() () 11 +7.99 +39.00 12-21.91 +4.70 13 +0.04() () 14 +59.82 +24.00 15 +62.57 +60.00 16 +8.65 +23.00 ( ) 17 +70.38 +66.00 18 +22.46 +31.00 19 +34.51 +46.00 20 / -21.49 +1.00 21-18.00-8.00 21 / / ( ) 14 21 67% TEL 01068558557 47 FAX 01068558370

---- 5 21 23.8% 2 21 9.2% 3. 100 WTO 100 100 50 100 50 100 50 4 4 1 1 - - 14 11 4 2 21 13 9 8 10 4 11 4 100 11 1 9 2 6-38 24 24 9 38 17 2001 100 : () 1 ( 1) 294096615 2 ( 3) 215886671 3 ( 2) 191086164 4 ( 7) 179799557 5 ( 6) 170757725 6 ( 8) 159057897 7 (10) 153441338 8 ( 4) 137982781 9 ( 5) 129198543 10 (12) 128011079 11 (16) 120727881 12 ( 9) 111676436 13 (11) ( ) 109174690 TEL 01068558557 48 FAX 01068558370

---- 14 (17) 106689136 15 (34) 100081811 16 (18) 98860088 17 (20) 89768359 18 (24) 86033068 19 (23) 80075199 20 (26) 77070250 21 (38) 74761786 22 (30) 73739176 23 (13) 72828625 24 (68) 71925143 25 (46) 71261940 26 (31) 66840946 27 (27) 66806105 28 (25) 66125112 29 (15) 66031668 30 (21) 65964130 31 (29) 64026060 32 (48) 62178210 33 (28) 61079788 34 (42) 58397104 35 (22) 57580706 36 (75) HOECHST(GE) 53597009 37 ( 0) CIBA-GEIGY LIMITED(SW) 52026267 38 (19) ( ) 51461159 39 (35) ELI LILLY INDUSTRY(US) 50382723 40 (51) 48736242 41 (65) 47914605 42 (32) 46798213 43 (56) 46634134 44 (35) ELI LILLY AND COMPANY(UK) 46236099 45 (52) 45869756 46 (39) 45833847 47 (53) 44734191 48 (40) 42785795 49 ( 0) 41910052 50 (24) DAIICHI SEIYAKU COMPANY LTD.(JA) 41216162 TEL 01068558557 49 FAX 01068558370

---- 51 (41) 39979433 52 ( 0) 39892287 53 (33) ASTRA(SD) 39390329 54 ( 0) 38349185 55 (81) 38345712 56 (61) 37707948 57 ( 0) 37181805 58 (36) 36881033 59 (87) 36543464 60 (47) 35860411 61 (67) 33986577 62 (44) 33934676 63 (69) 32901142 64 ( 0) 32893506 65 (72) 31863435 66 (88) 31828017 67 (54) 31414519 68 (49) 31343406 69 (89) 31098703 70 (60) 31011766 71 ( 0) 30900470 72 (79) 30101586 73 (99) 29889421 74 ( 0) ( ) 29773556 75 (97) 29674414 76 (86) 29630311 77 ( 0) SMITH KLINE & BEECHAM(UK) 29587045 78 ( 0) 29545644 79 (76) ( ) 29479464 80 (55) 29438021 81 (63) 29129305 82 ( 0) 28792547 83 ( 0) 28767695 84 ( 0) 28727162 85 ( 0) 28492112 86 ( 0) SCHERING-PLOUGH (BRINNY) COMPANY(IR) 27868934 87 ( 0) 27677097 TEL 01068558557 50 FAX 01068558370

---- 88 ( 0) 27637880 89 (14) BOEHRINGER MANNHEIM GMBH(GE) 27500971 90 (50) 26861350 91 ( 0) 26481113 92 ( 0) 26460654 93 ( 0) SCLAVO S.P.A.(IT) 25843436 94 ( 0) FRESENIUS AG(GE) 25707142 95 (76) ( ) 25595208 96 ( 0) - 25044501 97 ( 0) 25031538 98 ( 0) 24752370 99 ( 0) 24656554 100 ( 0) RHONE-POULENC RORER(FR) 24378435 2000 4 10 HOECHST(GE) SMLTHKLINE 17 10 ( ) ASTRA(SD) BOEHRINGER MANNHEIM GMBH(GE) 16 100 25 2 50 (5 ) 1 1 2 3 4 5 % 85.17 74.00 3 / 90.60 / 4 93.70 5 91.80 TEL 01068558557 51 FAX 01068558370

---- 6 0 83.47 7 99.90 8 / 80.30 9 93.50 10 / / 89.00 11 82.20 72.90 12 13 94.23 14 98.30 15 95.70 16 62.00 17 42.00 18 76.70 19 59.50 20-2 93.50 21 - - - 100.00 22 94.40 TEL 01068558557 52 FAX 01068558370

---- 23 95.50 24 50.70 25 - - - 100.00 26-100.00 27 83.00 28 80.00 29 100.00 30 VE 96.30 31 76.40 32 33 99.20 34 92.60 / 35 88.90 36 37 38 39 HOECHST (GE) CIBA- GEIGY (SW) ( ) ELI LILLY (US) 83.70 94.50-35 / 97.20 79.80 40 / 92.70 TEL 01068558557 53 FAX 01068558370

---- / 41 99.20 42 43 44 / - D 95.80 ELI LILLY (UK) 92.60 93.40 45 98.60 46 88.20 47 69.00 D 48 - - - 100.00 49 - - - - 100.00 50 DAIICHI SEIYAKU (JA) - - 100.00 2001 1997 16% 500ml 43%250ml 39% 100ml 17%50ml 1% 1. 1997 16 2000 23.7 2001 29 (%) 1997 2000 2001 ( ) ( ) ( ) -7.6000 0.0773 0.1022 0.0560 TEL 01068558557 54 FAX 01068558370

---- 9.7000 0.2199 0.8509 0.3200-6.1000 0.3860 0.7800 0.3000-0.0400 0.1035 7.9000 6.7827 10.0120 9.2000 37.3000 1.2063 4.1430 4.3000 21.4000 1.2924 3.7370 2.8000 7.1000 0.6256 0.8000 0.8300 10.8000 0.0593 0.0774 0.0900 17.3000 0.8982 1.5353 1.7000 0.3936 0.5152 0.4000 0.1594 0.1815 0.1500 2. 1 (%) 1998 1999 2000 2001 0.84 0.75 0.90 1.30 1.90 1.90 2.40 2.63 14.00 13.70 14.90 12.30-0.30 0.93 0.91 0.02 0.36 0.37 0.33 0.68 0.60 0.53 0.46 3.70 3.60 3.60 3.20 77.80 75.40 76.30 78.70 (%) 1998 1999 2000 2001 15.70 14.10 9.10 13.65 6.90 8.50 11.10 10.00 21.60 23.30 21.00 20.70 0.44 1.50 2.60 2.20 4.70 5.30 5.70 4.70 9.50 8.80 10.00 8.60 2.00 2.00 2.50 2.60 37.70 33.00 37.50 37.50 219992001 TEL 01068558557 55 FAX 01068558370

---- 1999 2000 2001 ( ) 5208 5672 7331 () 80 86 105 ( ) 39.75 48.41 58.90 ( ) 446.10 511.00 538.00 ( )( ) 3571.00 3873.00 5025.00 ( ) 26.84 35.86 32.40 ( ) 102.30 120.40 148.00 ( ) 237.00 261.00 279.00 ( ) 106.00 118.70 114.00 ( ) 297.00 278.00 279.00 ( ) 61.00 53.00 51.00 31998 2001 1998 1999 2000 2001 1 36.000 37.600 46.000 55.600 2 15.700 79.000 163.400 251.000 3 1825.000 1788.000 1900.000 2311.00 0 4 103.000 106.000 118.700 113.700 5 916.000 1056.000 1236.000 1796.00 0 6 12.700 20.000 19.600 22.800 7 58.700 58.000 72.200 82.700 8 3.800 7.900 11.300 13.600 9 15.500 12.400 14.110 11.220 10 151.400 150.000 138.700 127.300 11 8.500 10.700 16.100 16.800 12 74.000 65.500 63.000 102.700 13 96.300 102.600 113.900 112.500 14 6.000 16.000 18.300 23.000 15 447.000 469.000 457.000 597.000 16 195.000 150.000 132.000 81.200 17 12.200 11.400 15.000 15.200 TEL 01068558557 56 FAX 01068558370

---- 18 16.700 49.000 52.200 46.500 19 9.800 15.400 19.200 21.000 20-15.800 22.400 30.000 21 173.000 181.000 180.000 191.000 22 45.200 65.600 77.000 75.600 23 2.800 10.800 20.000 27.300 24 12.900 13.000 17.100 25.700 25 64.300 78.200 100.000 145.000 26 1.900 2.000 2.250 2.800 27 1.700 14.200 21.700 33.400 28 7.500 10.500 11.600 16.600 29 246.000 231.000 188.000 203.500 30 1.280 0.860 1.920 2.470 31-3.000 9.600 14.000 32 166.000 91.500 101.700 110.000 33-40 56.800 54.800 45.900 43.600 34 - - - 4.600 35 5.300 5.500 6.100 4.000 36-0.440 2.800 6.080 37 26.700 21.300 26.100 17.000 38 0.060 0.420 6.800 14.600 39 18.200 24.700 15.000 11.700 40 0.490 0.360 2.420 0.890 41 14s 4.000 4.840 5.800 6.600 42 10.000 6.600 2.700 1.150 43 5.200 4.300 5.500 5.300 44 14.600 18.700 15.500 9.000 MG3 45 NaHCO3 21.700 21.700 26.400 39.700 46-0.018 0.035 0.180 TEL 01068558557 57 FAX 01068558370

---- 47 4.000 2.600 4.640 6.300 48-20 4.800 5.900 7.200 7.600 49 5.900 8.700 7.030 3.640 50 7.100 10.600 9.000 6.000 NaCl NaCl MG3 6% 4.6% TEL 01068558557 58 FAX 01068558370