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(CIP) /. :,2005 ( /, ) ISBN 7 81010 910 3.......... R247.1 TS927.161 CIP (2005) 105125 ( ht tp : / / www. tcmonline. com. cn ) ( 1200 201203 ) 787 mm 1092 mm 1/ 32 8.375 182 1 4 100 2005 11 1 2005 11 1 ISBN 7 81010 910 3/ R 858 18.00 (, 021 51322545 )

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,,,, ;,,,,,,,, ;,,,,, ;,,, : ; ;,,,,, 2005 8 10

: 2 1. ( 2 ) 2. ( 2 ) 3. ( 3 ) 5 1. ( 5 ) 2. ( 6 ) 3. ( 6 ) 4. ( 6 ) 7 1. ( 7 ) 2. ( 8 ) 10 1. ( 10 ) 2. ( 16 ) 3. ( 18 ) 4. ( 22 ) 5. ( 23 ) 26 1.? ( 26 ) 2. ( 27 ) 3. ( 28 ) 4. ( 28 ) 5.? ( 29 ) ( 30 ) 6., 31 1. ( 31 ) 2. ( 32 ) 3. ( 32 ) 4. ( 32 )

2 1. ( ) ( 33 ) 2. ( ) ( 34 ) 3. ( 35 ) 4. () ( 35 ) 5. ( 36 ) 6. ( 37 ) 7. ( 38 ) 8. ( 38 ) 9. ( A/ G ) ( 39 ) 10. ( 39 ) 11. ( 39 ) 12. ( 40 ) 13. ( 43 ) 45 1. ( 45 ) 2. ( 45 ) 3. ( 46 ) 4. ( 45 ) 5. ( 46 ) 6. ( 46 ) 7. ( 46 ) 8. ( 47 ) 9. ( 47 ) 10. ( 47 ) 11. ( 48 ) 12. ( 49 ) 13. ( 50 ) 14. ( 50 ) 15. ( 51 ) 16. ( 51 ) 17. ( 52 ) 18. ( 52 ) 53 1. ( 53 ) 2. ( 54 ) 3. ( 54 ) 4. ( 54 ) : 56

3 ( 56 ) 2. ( 57 ) 3. ( 58 ) 4. ( 59 ) 5. ( 60 ) 6. ( 61 ) 7. ( 62 ) 8. ( 63 ) 9. ( 63 ) 10. ( 65 ) 11. ( 66 ) 12. ( 67 ) 13. ( 68 ) 14. ( 69 ) 70 1. ( 70 ) 2. ( 71 ) 3. ( 71 ) 4. ( 72 ) 5. ( 73 ) 6. ( 73 ) 7. ( 74 ) 8. ( 75 ) 9. ( 76 ) 10. ( 77 ) 11. ( 78 ) 12. ( 78 ) 13. ( 80 ) 14. ( 81 ) 15. ( 82 ) 16. ( 83 ) 17. ( 84 ) 18. ( 85 ) 19. ( 86 ) 20. ( 87 ) 21. ( 88 ) 22. ( 89 ) 23. ( 89 ) 24. ( 90 ) 92 1. ( 92 ) 2. ( 93 ) 3. ( 94 ) 4. ( 95 ) 5. ( 96 ) 6. ( 97 ) 7. ( 98 ) 8. ( 99 ) 9. ( 99 ) 10. ( 100) 11. ( 101 ) 12. ( 101 ) 13. ( 102 ) 14. (103 ) 15. ( 103 ) 16. ( 104 ) 17. (104 ) 18. (105 ) 107 1. (107 ) 2. (108 ) 3. ( 109) 4. (110 ) 5. ( 110) 6. (111) 7. ( 112) 8. (113 ) 9. (114 ) 10. ( 114) 11. ( 115 ) 12. ( 116 ) 13. ( 117 ) 14.

4 118 ) 15. ( 118 ) 16. ( 119 ) 17. (121 ) 18. ( 123 ) 19. ( 124 ) 20. (125 ) 21. ( 125 ) 22. ( 127 ) 23. (128 ) 24. ( 129 ) 25. ( 130 ) 26. (130 ) 27. ( 131 ) 28. ( 132 ) 29. (132 ) 30. ( 133 ) 31. ( 134 ) 32. (134 ) 33. ( 136 ) 34. ( 137 ) 35. (137 ) 36. ( 138 ) 37. ( 140 ) 38. ( 141 ) 39. ( 142 ) 40. ( 142 ) 41. ( 143 ) 42. ( 144 ) 43. ( 144 ) 44. ( 145 ) 45. ( 145) 46. ( 146) : 148 152 1. (152 ) 2. ( 152) 3. ( 152 ) 4. ( 152 ) 5. (153 ) 1. (153 ) 2. ( 153) 3. (153 ) 4. ( 154) 5. ( 154) 6. (155 ) 7. ( 155)

5 (155 ) 2. ( 156) 3. (156 ) 4. ( 157 ) 5. ( 157 ) 6. (158 ) 1. (158 ) 2. ( 159) 3. ( 159 ) 4. ( 159 ) 5. (160 ) 6. ( 160) 160 161 165 1. (165 ) 2. ( 166) 1. (166 ) 2. ( 166) 3. (166 ) 4. ( 167) 1. ( 167 ) 2. ( 167 ) 3. (168 ) 4. ( 168) 5. (168 ) 6. ( 168) 1. ( 169 ) 2. ( 169 ) 3. ( 169 ) 4. ( 170) 5. ( 170 ) 6. (170 ) 7. ( 171 ) 8. (171 )

6 171 174 1. ( 174 ) 2. ( 175 ) 3. (175 ) 4. ( 175 ) 5. ( 175 ) 6. (176 ) 7. ( 176) 1. (177 ) 2. ( 177) 3. (177 ) 4. ( 178 ) 5. (178 ) 1. (179 ) 2. ( 179) 3. (179 ) 4. ( 180 ) 5. (180 ) 6. ( 180 ) 7. ( 181 ) 8. (181 ) 1. (182 ) 2. ( 182) 3. (182 ) 4. ( 183) 5. (183) 183 184 185

7 1. (185 ) 2. ( 186) 3. ( 186 ) 4. ( 186 ) 5. ( 187 ) 6. (187 ) 7. ( 187) 8. (188) 1. ( 188 ) 2. ( 188 ) 3. ( 189 ) 4. ( 189 ) 5. ( 189 ) 6. (189 ) 1. (190 ) 2. ( 190) 3. (190 ) 4. ( 191 ) 5. (191 ) 6. ( 191 ) 7. ( 191) 8. (192 ) 1. (192 ) 2. ( 192) 3. ( 193 ) 4. ( 193 ) 5. (193 ) 6. ( 193 ) 7. ( 194 ) 8. (194 ) 9. ( 194 ) 10. (194 ) 11. (195 ) 12. (195) 196 196 198 1. (198 ) 2. ( 198) 3.

8 198 ) 4. ( 199) 5. (199) 1. (200 ) 2. ( 200) 3. ( 200 ) 4. ( 201 ) 5. (201 ) 6. ( 201 ) 7. (202 ) 1. (202 ) 2. ( 203) 3. (203 ) 4. ( 203 ) 5. (204 ) 6. ( 204 ) 7. ( 205 ) 8. ( 205 ) 9. ( 206 ) 10. ( 206) 11. ( 206) 1. (207 ) 2. ( 207) 3. (207 ) 4. ( 208) 5. ( 208) 6. ( 208 ) 7. ( 209 ) 8. (209 ) 9. ( 209) 10. ( 210 ) 11. ( 210 ) 12. ( 210 ) 13. (211 ) 14. ( 211 ) 15. ( 211 ) 16. ( 212 ) 17. ( 212 ) 18. ( 213 ) 19. ( 213 ) 20. (213 ) 21. ( 214) 22. ( 214 ) 23. ( 214 ) 24. (215 ) 215

9 218 1. (218 ) 2. ( 218) 1. ( 218 ) 2. ( 218 ) 3. (219 ) 4. (219 ) 5. ( 219 ) 1. (220 ) 2. ( 220) 3. (220 ) 1. (221 ) 2. ( 221) 3. (221 ) 221 222 224 1. (224 ) 2. ( 225) 3. (225 ) 4. ( 225 ) 5. (226 ) 6. ( 226) 7. (226)

10 ( 227 ) 2. ( 227 ) 3. (227 ) 4. ( 228) 5. (228) 1. (229 ) 2. ( 229) 3. (229 ) 4. ( 230 ) 5. (230 ) 6. ( 230 ) 7. ( 231 ) 8. ( 231) 9. ( 231 ) 10. (232 ) 1. (232 ) 2. ( 233 ) 3. ( 233) 4. (233 ) 5. ( 234) 6. (234 ) 7. ( 234) 235 235 238 1. (238 ) 2. ( 238) 3. (238 ) 4. ( 238 ) 5. (239 ) 6. ( 239) 7. (239) 1. (239 ) 2. ( 239) 3. (240 ) 4. ( 240 ) 5. ( 240 ) 6. (241 ) 7. ( 241) 8. (241 ) 9. ( 242)

11 1. (242 ) 2. ( 242) 3. (242 ) 4. ( 243) 5. ( 243 ) 6. ( 243 ) 7. (243 ) 8. ( 244 ) 9. ( 244 ) 10. ( 244) 11. ( 244) 1. (244 ) 2. ( 245) 3. (245 ) 4. ( 245 ) 5. ( 246 ) 6. (246 ) 7. ( 246) 8. ( 246 ) 9. ( 247 ) 10. ( 247 ) 11. ( 247) 247

2,,,, ; ; 2,,,,,,,

3 H, ;,, ;,,, 3,,,,,, 25,5 000, 50, 20 30, 6 8, 4 900,,, : : : 1 000 2 000, 70, ( ALT SG P T, ) :

4,, :,,,,,, : 50,,,, : :

5,,,,, ;,,,,,,

6,,, ;,,,,,,, 3,,,,,,, 4,,,,,,,,,,,,,,

7?,,,,,, :,,,,,,, ;,

8,,,,,,,,,,,,,,,,, 2,, ;,,,,,,, ;,,,,,,,,,,,,,

9,,,

10,, : (1 ) :,,,,,,,,, (2 ) : EB

11 (3 ) :,,, (4 ) : :, ;,,,,, (5 ) :,,,,,,,,,, 15 45, 30 ; 6 6, 3 ;

12 12, 7 8,, :,,,,,,,, 1 :,, 1 2,,,,,,,, ( GP T ALT ) 2 6 :,,,,,, 1 2 5%,,, 60 % 80%,,

13,,, AL T, 3,, AL T,,, ( ),, ( HBsAg) e ( H BeAg ) 85% 95%,, 2/ 3,,, AL T,,,, ALT ( GT ),, DN A ( HBV DNA ),

14 DN A DNA P ),, ( ), 1/ 3,, 10,, 6, 8,,,,, ;,,,,,,,,, ALT,,,,

15 ALT AST, AS T/ ALT > 1, > 2,, / ( > 25% ),,, 85.5 122.8 mol/ L,,, 50%, 40% BSP ICG, 5%, ICG BSP, BSP BSP ICG -GT, : : 90 %,,, HBsA g - HCV, :,,,, ALT AST,, :, 171 mol/ L, ALT, :

16,,,,, < 40 %,,, /,,,,,, ;,, 2,,,,, D,,, 4% 7 %,,,, ( ) 10% 10% 25 %, 25% 50%, 5%, 1/ 3,,

17,,,,,,,,,,, : (1 ) :,, (2 ) :, (3 ) : (4 ) : (5 ) :,, (6 ) :

18,, 25 %,,,,,,,,,,,,,, ( ),,, 3,,,,,,

19,,,,,,,,,,,,, 35 48,, 4 1 8 1, 10%,,,,,,,, ( ) ; ; ;,,,,,

20, (1 ) :,,,,,,,,,, (2 ) :, :,,,, :,, ;,,, 60 %,, :,,,,,,,,2/ 3,

21 :,,,,,,, : :, :,, ( ) :,,,,, : 50% 60%,,,,,, :,, ;,, :, :,, 2 cm,,,,

22, :, : ( 5 % ),, 4,, ;, : (1 ) :,,,, (2 ) :,,, (3 ) :,,,

23,, (4 ) :,,,, 5, : :,,, 26, 42.5%,

24,,,,,, 20 % ; 56% ;, 16.5 % 51.5% ; 26%,,, ;, 5 8,,, B ( AF P), CT, A FP, B CT,,,,,,,, 10 ;

25,, 10,, 5 60% 70% ;,,, 6,,, 5 2.6% 20.6 % 80%,,,,

26?, 8 12, 4 6, 40 60, : : 40 60,, : 600 1 200, 6 10 :,,,,

27 20,, : A D E K,, 2 40,,,,, ( 38 ),, : (1 ) :, 80%,,, (2 ) :,,,

28 :,,,,, 3,,,,,, : (1 ) :, 65 % 75%,,,, (2 ) :, 4,,,,,,

29,,,,,,,,,,, 40, 12 24,,, 5?,,,,,,,,,,

30,, : (1 ) :,,, (2 ) :,, (3 ) :, (4 ) :,,,,

31,,,,,,,,,,,,,,,

32,,,, 3,,, ;, ;,,,,, 4,,,,

33, + + - -,,,, 1 () ALT ( GP T, SG P T) < 40 U/ L() (1 ) ALT,, AL T

34,, ALT > 400 U/ L, ;, ALT ;, ALT,,, ALT, (3 ), ALT, 400 U/ L 2 () AS T (GOT, SGOT ) < 40 U/ L (1 ) AST ALT AS T ALT, AST,, AS T (2 ) AST/ ALT, 1.15;, AS T/ ALT < 1,,, ;, AST/ ALT > 1;, AST/ ALT > 3 (3 ) AST, AST,,, AST

35 ALP, A KP 1 12 : < 500 U/ L 12 15 : < 750 U/ L : < 150 U/ L (1 ) ALP, ALP 5, ALP 2, ; AL P, 2 3 (2 ) AL P, ALP, (3 ), ALP, X, (4 ) ALP, 4 () GT, GGT

36 U/ L (1 ) r GT,, r GT ;,, r GT (2 ) r GT, (3 ), GT, 5 LD, LD H LD : 109 245 U/ L LD : LD1 24% 34 %, LD2 35% 44%, LD3 19% 27%, LD4 0% 5 %, LD5 0% 2%, LD, LD LD LD1 LD2 LD3 LD4 LD5, : LD2 > LD1 > LD3 > LD4 > LD5 LD1 (1 ) LD, LD1, > LD2, (2 ) LD, LD5, LD5 > LD4 ;, LD4 > LD5

37 LD, LD5, (4 ) LD, 6 ( ) ( ) TBiL( ), DBiL( ), IBiL ( ) dl] TBiL : 5.1 19.0 mol/ L [0.3 1.1 mg/ DBiL : 1.7 6.8 mol/ L[ 0.1 0.4 mg/ dl] IBiL : 3.4 17.0 mol/ L[0.2 1.0 mg/ dl],, (1 ) TBiL IBiL, DBiL,, IBiL (2 ) TBiL DBiL, IBiL,,, DBiL (3 ) TBiL IBiL DBiL,,, IBiL ;,, DBiL

38 T P 60 80 g/ L[6.0 8.0 g/ dl] (1 ) : 1), 2) 50,, (2 ) : 1),, 2), ;, ;, 3), (3 ) : 1),, 2), 8 ALB

39 55 g/ L[3.5 5.5 g/ dl] 9 ( A /G ) A/ G 1.5 2.5 (1 ) A/ G, A/ G,, (2 ) A/ G, 10 TBA < 10 mol/ L, TBA, TBA, TBA 11 CHE

40 000 12 000 U/ L (1 ) C HE,,, CHE (2 ) CHE, CH E, (3 ), C HE ;, CHE, 12,,,,,,, ( ) HBsAg H AA

41, ( ),,,,, HBsAg, HBsAb ( HBs ) : 1. 2., 3. HBs, HBcAb ( HBc) : (,, ), e HBeAg 1.,

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43 H Bs Ag HBs H BeAg HBe H Bc - + - - - - + - + + H BV,, - + - - + + - - - + HBV, H BsAg + - - + + + - + - + H BV, ( ) HBV, ( ) + - - - - HBV + - + - - - - + + + HBV + - + + + HBV + - - + - - - - + - - + - + - H BV 13,

44 H A VAb IgM HCV Ab H DVAb IgM HDIgM, HDIgM ;, HDIgM HDIgM, HEV Ab H GV Ab ( :,,,2002 1 1 )

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70 [ ],,,,,, [ ] : 120, 150,,, [ ],

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88 21 [ ],,, ; ;, [ ] (1 ) : 80, 250,,,,, 5,,, 1 (2 ) : 150, 100,,,, 1, 10 (3 ) : 100, 200, 100, 5, 30,, ;, 5 ;, ;, ;,,,, 50,,, 15 [ ],,

89 2 [ ],,,,,,,, [ ] : 50, 15, 30,, 1, 3 5 [ ], 23 [ ],,,,,,,,,,,, B1 B2,, [ ] (1 ) : 10, 3, 3, 6,,, (2 ) :,, 30,,

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96 1, 2 [ ], ;,,,,,,,, 5 [ ],,,,,,,,, [ ] : 100 150, [ ],,

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103 ], 14 [ ],,,,,,,,,,,, [ ] [ ],,, 15 [ ],,,,, ;,,, [ ] : 250, 30 60, 60, [ ],,,,

104 6 [ ],,,,,,, 50 %,,, 40%,,,, [ ] : 25, 50, 5,, [ ],,, 17 [ ],,,, C, [ ] (1 ) : 5 6,, 1, 10 (2 ) 100, 40,, 2

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107 [ ],,,, A,, A, [ ] ( 1) : 100, 50, 100, (2 ) : 20, 100,,,,

108, (3 ) : ( ) 10, 10, 100 4,,,, 1, 20 (4 ) : 100, 150,,, 2 3,, (5 ) : 80, 250,,,,, 5,,, 1 (6 ) : 100, 40, 20, 1,,,, (7 ) : 100, 100, 1, 20 [ ], 2 [ ],,,

109, [ ] : 100, 20, 30, 100, 30, 10, 5, 10, 5, 30, 4, 3, ; ;, 5,3 ;, 5,,,,, ;,, 20, ;,,,,, 300, 15 : 1, 50, 3 [ ],,, A D [ ] ( 1) : 12, 100, 5, 3, 20, 20,,,, ;,,, 250,, 5,, 5 1, 50,

110 : 50, 15, 100,, 1, 15 20 ( 3) : 250, 20,, 4 [ ],,, A D [ ] : 200, 12, 9, ( ) 100, 10, 5, 20, ;, ;, 5 ;, ;,,,, 300,,, 10 1, 50,,,, 5 [ ],,,, A

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113,,,,,, (6 ) : 2, 15, 15, 15,,,, (7 ) : 250, 250, 100, (8 ) : 30, 50, 30, 30, 5, 20, 600,,, 100,, ; ;, ;,,,, 600 ;,, [ ], 8 [ ],,, [ ] : 250, 10, 9, 1,,,,,

114,,,,, [ ], 9 [ ],,,,,, [ ] : 10, 100, 10, 5, 3, 300, ;, 2 ;, ;, ;, 1 1, 50 [ ] 10 [ ],, A B1 B2 B12, ( ) [ ] : 500, 1 000,

115,, 30, 30 40,1 1 11 [ ],,,,,, ( ) [ ] (1 ) : 15, 100, 50, 5, 30, 20, 1,, ;, ;, 4 3 ;, ;,,, ;,,,, 600 ;,, 10 (2 ) : 250, 100,, ( 3) : 200, 6, 100, ( ),,,,,,,

116 : 200, 3, 1,, [ ] ;,,, 12 [ ],,,,,, B1 B2 B6 [ ] ( 1) : 100, 200, 50,,,,,,,,,,,,,,,,,,, 10 1 ( 2) : 30, 200,,,,,,

117 : 200,, 30,,,, [ ] 13 [ ],,,,,, [ ] (1 ) : 250, 50, 100,,,,, (2 ) : 100, 100,, ( 3) : 120, 30,,, 1 [ ],

118 4 [ ],,,, ( ), [ ] (1 ) : 500, 50,,,,, (2 ) : 200, 40,,,,, 20,,,, (3 ) : 15, 25, 250,,,,, 1, 20 [ ] 15 [ ],,,, B1 B2 [ ]

119 : 6, 9, 500, 10, 5, 10 ( ) ;,,,,, ;,,,, 300 ;, 50 1, 50, (2 ) : 5, 5, 1,,, 1 ( 100 150 ), (3 ) : 1, 3, 3, 6, 2,,, 2 3 ( 4) : 1 ( 700 ), 10, 250,,, (5 ) : 3, 1 ( 500 ), [ ], 16 [ ],,,

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123 18 [ ],,,,,, ( ) [ ] (1 ) : 6, 9, 1, 5, 10,,,, ;, 250 ;, 40 2,, 100 (2 ) : 30, 30, 1,, (3 ) : 1,, ( ) (4 ) : 30, 1,,,,,, 1, 2, (5 ) : 1, 250, 50, 3, 4,,

124,,, [ ],,, 19 [ ],,,,,, ( ) [ ] (1 ) : 100, 200, 20,, ;, 100,, 25, ;, 1, 1 (2 ) : 80, 45, 60, 2 000,,,,,,, 1, 2, 20 ( 3) : 200, 50,,

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127 2 22 [ ],,,,, B1 B2,,, [ ] (1 ) :,,, (2 ) : 2, 1, 1 ( 3) : 250, 100, ( 4) : 250, 50,,, ( 5) : 30, 100,, 1, 20 (6 ) : 50, 50, 50, 200, 5 ;,

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129 24 [ ],,,,, A B1 B2, [ ] (1 ) : 30, 50, 20, 300, 5, 30, ;, ;,, ;, ;,,,, 600,,, 30,, 15 1, 2 (2 ) : 500,,, (3 ) : 15,,,,,,, 15 [ ],

130 5 [ ],,,,,, 20,, [ ] (1 ) : 12, 30, 50, 5, ;, ;, ;,,,, 250 ;, 25, 1, 1, (2 ) : 2, [ ],, ( ), 26 [ ],,,,,,,,

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134 : 150, 3,,,,, [ ], 31 [ ],,,,,,,,,, [ ] : 1 ( 500 ), 600, 3, 3, 1, 2,,,,, ;,,, 1 ;,,,,, [ ], 32 [ ],

135,,,,,,,,,,,,,,,, A B1 B2 [ ] (1 ) : 500 ( ), 50, 100, ( ), (2 ) : 200, 9, 6, 9,,,,, 1, 20 ( 3) : 200, 10,, ( 4) : 10, 250, (5 ) : 500, ( ),,, 1, ( 6) : 200, 30, 10, 3,,,, [ ],

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140 : ( 500 ), 15, 30,,, [ ],, 37 [ ],,,,, [ ] ( 1) : 15, 100, 100, 5, 20,,,,,,, ;,,,, 300, 60 1, 50,,,, (2 ) : 250, 50, 10,, ( 3) : 1 ( 250 ), 30, 15, 3,,,,,

141 8 [ ],,,,,,,,,,,,, A B2 [ ] (1 ) : 30, 100 (2 ) 2 000,, 3, 10 15 1, 4 (3 ) : 30, 150,, ( ) (4 ) : 120,,,,, 1, 7 (5 ) : 150, 100,,,, 1, 10 [ ],,,

142 9 [ ],,,,,,, [ ] (1 ) : (2 ) : 15, 250,, 1 [ ],, 40 [ ],,,,,, [ ] (1 ) : 100 150, 400,,,, 1, (2) : 1 ( 500 ), 20, 300,,, 100,,

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