40 1 Vol 40 No 1 2016 1 Journal of Jiangxi Normal UniversityNatural Science Jan 2016 1000-5862201601-0093-05 PMAA-co-AAm/Fe 3 O 4 1 2 1 2 1 2 1 756002 756000 Fe 3 O 4 -co- PMAA-co-AAm Fe 3 O 4 PMAA-co-AAm/Fe 3 O 4 SEM PMAA-co- AAm/Fe 3 O 4 ph 7 4 8 h ph 1 4 PMAA-co-AAm/Fe 3 O 4 ph PMAA-co-AAm/Fe 3 O 4 TU 375 A DOI10 16357 /j cnki issn1000-5862 2016 01 17 0 ph 1-2 PMAA-co-AAm Fe 3 O 4 OH COOH NH 2 CHO PMAA-co-AAm/Fe 3 O 4 3 1 4-6 1 1 NaOH H 3 PO 4 HCl NaH 2 PO 4 2H 2 O Na 2 HPO 4 12H 2 O C 7 H 8 N 4 O 2 2015-10-15 NZ12226 2011 263 1976-
94 2016 1 2 50 ml DZF-6050 5 g L - 1 7 50 ml 5 g L - 1 SK3300LHC 50 ml TGL-16B 1 0 10-3 2 0 VFD1000 10-3 4 0 10-3 6 0 10-3 8 0 10-3 1 0 10-2 PHS-25 1 2 10-2 mg L - 1 - TU- 272 nm A 1901 c A 1 3 PMAA-co-AAm/Fe 3 O 4 2 4 2 PMAA-co-AAm/Fe 3 O 4 7 P MAA-co-AAm/ Fe 3 O 4 5 g L - 1 2 PMAA-co-AAm/Fe 3 O 4 3 d 2 1 PMAAco-AAm/Fe 3 O 4 JEOL JSM-5900 LV 2 4 3 3 Fe 3 O 4 Fe 3 O 4 PMAA-co-AAm/Fe 3 O 4 100 ml ph 1 4 7 4 PMAA-co-AAm/Fe 3 O 4 7 d 100 ml 3-50 24 h FEI 37 100 r min - 1 Quanta200 272 nm 2 2 NETZSCH 209 F1 A = K 1 c + K 0 K 1 = 72 733 11 PMAA-co-AAm/Fe 3 O 4 K 0 = 0 033 63 Fe 3 O 4 50 ml min - 1 10 min - 1 3 40 800 ± 0 1 ± 0 05 3 1 2 3 PMAA-co-AAm/Fe 3 O 4 ph 1 1a 1b Fe 3 O 4 2 3 1 Fe 3 O 4 12 ~ 16 nm 17 ~ ph 1 4 2 8 8 6 11 0 20 nm 12 5 nm 18 0 nm 2 I = 0 2 M 8 PMAA-co-AAm/Fe 3 O 4 ph TP-310 2a 2b PMAAco-AAm/Fe 2 3 2 3 O 4 BI-90Plus 1 5 ~ 2 3 μm 2 0 μm ph PMAA-co-AAm/Fe 3 O 4 2b ph 2 4 2 4 1 0 25 g
1 PMAA-co-AAm/Fe 3 O 4 95 afe 3 O 4 b Fe 3 O 4 1 3 3 PMAA-co-AAm/Fe 3 O 4 ph 4 ph 4 ph ph 1 4 ~ 2 8 ph 2 8 ~ 7 0 ph 7 0 ~ 8 7 ph ph ph 7 0 8 7 11 0 PMAA ph 1 4 PMAA 9-10 a bpmaa-co-aam/fe 3 O 4 2 3 2 3 Fe 3 O 4 3 120 1 25% 250 ~ 350 4 ph P MAA-co-AAm COOH 3 4 PMAA-co-AAm/Fe CONH 3 350 ~ 480 3 O 4 PMAA-co-AAm 480 PMAA-co-AAm/Fe Fe 3 O 4 3 O 4 ph 3 26 30% MAA AAm Fe 3 O 4 ph 7 0 S ph 1 4 I ph 7 4 Fe 3 O 4 Peppas 12 M t /M = kt n 1 M M t t k n 5 8 h 8 h 70% 3 PMAA-co-AAm/Fe 3 O 4 TG
96 2016 PMAA-co-AAm/ Fe 3 O 4 ph I 66 S k nn 0 5 Fickian 0 5 < n < 1 0 Fickian 1 0 5 Fickian n > 0 5 Fickian P MAA-co- AAm/Fe 3 O 4 PMAA-co-AAm/Fe 3 O 4 PMAA-co-AAm/Fe 3 O 4 lnm t /M = lnk+ n lnt 2 PMAA-co-AAm/Fe 3 O 4 Peppas Ritger-Peppas 2 5 1 n < 5 PMAA-co-AAm/Fe 3 O 4 ai b cs 6 Ritger-Peppas 13 1 4 R 2 n lnk I y 1 = 0 486 8x - 0 914 5 0 999 6 0 486 8-0 914 5 y 2 = 0 4768x - 0 9953 0 999 3 0 476 8-0 995 3 S y 3 = 0 592 9x - 1 409 4 0 993 2 0 592 9-1 409 4 AAm/Fe 3 O 4 ph P MAA-co- PMAA-co-AAm/Fe 3 O 4 AAm/Fe 3 O 4 SEM 5 ph 7 4 8 h 1Suslick K S Fang Mingming Hyeon T Sonochemical synthesis of iron colloids J J Am Chem Soc 1996 118 ph 1 4 47 11960-11961 8 h 70% P MAA-co- 2 J
1 PMAA-co-AAm/Fe 3 O 4 97 2003 201 27-32 polymer network J J Appl Polym Sci 2005 98 4 3Zborowski M Moore L R Williams P S et al Separations 1720-1726 based on magnetophoretic mobility J Sep Sci Technol 9Zhang Kaipu Luo Yanling Li Zhanging Synthesis and 2002 379 3611-3633 characterization of a ph- and ionic strength-responsive hy- 4Toublan F J Bopart S Suslick K S Tumor targeting by drogel J Soft Mater 2007 54 183-195 surface-modified protein microspheres J J Am Chem 10 - Soc 2006 12811 3472-3473 J 5Shao Mingfei Ning Fanyu Zhao Jingwen et al Preparation 2012 362 205-208 of Fe 3 O 4 @ SiO 2 @ layered double hydroxide core-shell mi- 11Liu Zhanqing Luo Yanling Zhang Kaipu P AAm-cocrospheres for magnetic separation of proteins J J Am MAAsemi-IPN hybrid hydrogels in the presence of PANI Chem Soc 2012 1342 1071-1077 and MWNTs-COOHimproved swelling behavior and me- 6 chanical properties J J Biomater SciPolym Ed 2008 J 1911 1503-1520 2011 356 574-578 7 PMAA- co-aam/fe 3 O 4 J 2012 296 797-803 8Chen Shilan Liu Mingzhu Jin Shuping et al Synthesis and swelling properties of ph-sensitive hydrogels based on chitosan and polymethacrylic acidsemi-interpenetrating 12Ricka J Tznaka T Swelling of ionic gelsquantitative performance of the Donnan theory J Macromolecules 1984 1712 2916-2921 13Serra L Domenech J Peppas N A Drug transport mechanisms and release kinetics from molecularly designed poly acrylic acid-g-ethyleneglycolhydrogels J Biomaterials 2006 2731 5440-5451 The Characterization and Drug Release Behavior Research of PMAA-co-AAm/Fe 3 O 4 as Polymer Magnetic Microsphere DI Hongwei 1 2 CAO Jiangping 1 2 WEI Juanjuan 1 2 1 College of Chemistry and Chemical Engineering Ningxia Teachers University Guyuan Ningxia 760000 China 2 Engineering and Technology Research Center of Liupanshan Resources Ningxia Normal University Guyuan Ningxia 756000 China AbstractMagnetic polymer microsphere is a polymeric microsphere with magnetic response prepared by combining polymers with inorganic magnetic materials Fe 3 O 4 based on a microencapsulation method It can be observed by SEM that PMAA-co-AAm/ Fe 3 O 4 microspheres have an obvious cross-linked mesh structure with good distribution The drug controlled release experiment with theophylline indicated that the release rate in ph 7 4 buffer solution and the distilled water were more rapid and the drug controlled release reach the balance in about 8 hours However the drug controlled release rate in ph 1 4 buffer solution is very small indicated that PMAA-co-AAm/ Fe 3 O 4 microspheres have obvious ph response so the crosslinked microspheres loaded drug can automatically adjusted with the drug release rate in acidic gastric juice and alkaline gut and have the target drug release effect PMAA-co-AAm/ Fe 3 O 4 crosslinked magnetic microsphere can be used as the target drug delivery carrier Key wordsfe 3 O 4 cross-linked structuremagnetic microspherescontrolled drug release