7 11 Vol. 7 No. 11 2016 11 Journal of Food Safety and Quality Nov., 2016 赵 婷 1, 周明强 1,2*, 徐聪 1, 刘伟丽 1,2, 赵新颖 1,2 (1.,, 100089; 2., 100089) 摘要 :,,,,,,,, 关键词 : ; ; ; Application of inductively coupled plasma mass spectrometry in drug elemental analysis ZHAO Ting 1, ZHOU Ming-Qiang 1,2*, XU Cong 1, LIU Wei-Li 1,2, ZHAO Xin-Ying 1,2 (1. Beijing Centre for Physical and Chemical Analysis, Beijing Key Laboratory of Organic Materials Testing Technology & Quality Evaluation, Beijing 100089, China; 2. Beijing Academy of Science and Technology Key Laboratory of Analysis and Testing Technology, Beijing 100089, China) ABSTRACT: Heavy metals and harmful metals in drugs and pharmaceutical raw materials such as As, Hg, Pb, Cr, Cd, etc. do harm to human health, while the excessive or insufficient intake of microelements and mineral elements in drugs and pharmaceutical raw materials such as Fe, Cu, Zn, Mn, Se, Si, etc. can cause different levels of human physiological abnormalities. Therefore, it is important to detect elements in drugs for quality control. Atomic absorption spectrometry, inductively coupled plasma spectrometry, atomic fluoresce spectrometry, colorimetry and inductively coupled plasma mass spectrometry (ICP-MS) are common detection methods of elements. The article summarized the applications of ICP-MS in drug testing, such as heavy metals and harmful metals, microelements and mineral elements, conventional elements, isotopic elements, and element speciation test. The results showed that the 基金项目 : Ⅲ-1(2015-178305) Fund: Supported by the Innovation Project Ⅲ-1 of Beijing Academy of Science and Technology (2015-178305) * 通讯作者 :,, E-mail: 111-aaaddd@163.com *Corresponding author: ZHOU Ming-Qiang, Research Assistant, Beijing Centre for Physical and Chemical Analysis, Beijing 100089, China. E-mail: 111-aaaddd@163.com
11, : 4353 liner relationships, precisions, detection limits and recoveries could meet the detect requirements completely. Due to low detection limit, wide linear range, multi-element determination and isotope detection at the same time, and accomplishment of element speciation analysis when combined with other separation equipments, ICP-MS has been widely applied in the detection of elements in drugs. KEY WORDS: drug; element; heavy metal; inductively coupled plasma mass spectrometry 1 引言,, (As) (Hg) (Pb) (Cr) (Cd) [1],,, (Fe) (Cu) (Zn) (Mn) (Se) (Si) [2] [3,4] [5] [6,7] [7] (inductively coupled plasma mass spectrometry, ICP-MS) [8-10], ICP-MS,, ICP-MS 2 ICP-MS 概述 (ICP) (MS), ICP, (atomic absorption spectroscopy, AAS) (inductively coupled plasma atomic emission spectrometry, ICP-AES) (atomic fluorescence spectrometry, AFS), ICP-MS, ICP-MS,, ICP-MS, (μg/ml ) (7~9 ),,, ICP-MS [2], 3 ICP-MS 在药品检测中的应用 3.1 重金属及有害元素检测 3.1.1 中药及中药制剂,,,,, [11] ICP-MS 5,, 0.8%~1.4%, 88.79%~109.36%, [12] ICP-MS 5,, [13] ICP-MS 14, 14 10%, 96.49%~114.04%, 3.1.2 西药及其原料药,,,, [14] ICP-MS B 2,,, 0.083 ng/ml,, 92.4%~101.7%, 3.2 微量及矿物质元素检测,, [15] Bi Sc
4354 7 In Y, ICP-MS 12,, 0.999, 2.30 μg/l, 91.1%~107.1%, 7, 3.7%,, 12 [16] ICP-MS 9 [17] ICP-MS Li Mg K Ca V Cr Mn Fe Cu Zn As Rb Sr Cs Pb 15, 0.999, 8%,,, 3.3 常规元素检测 ICP-MS,,, [18] ICP-MS 23 Be Al V Cr Mn Fe Co Ni Cu Zn As Se Mo Ru Pd Ag Cd Sn Sb Te Ba Nd Dy Er Ir Hg Tl Pb U 29,,,,, 3.4 同位素元素检测 ICP-MS,, (B) 10 B 11 B 2, 10 B, 10 B, [19] NIST SRM 951, ICP-MS,,,, [20] ICP-MS, ICP-MS,,, 3.5 元素形态检测, ICP-MS, [21], ICP-MS 0.9991 0.9995, 98.3% 98.7%,,, ICP-MS B 2,,, 4 ICP-MS 在本单位的应用 4.1 药品的定性检测, ICP-MS,,, 1, 1 表 1 半定量测试结果 Table 1 Results of semi-quantitative analysis Li <66.3 µg/kg Cd <2.17 µg/kg Be <75.8 µg/kg In 31.6 µg/kg B <121 µg/kg Sn 30.3 mg/kg Na <7.69 µg/kg Sb <0.744 µg/kg Mg <15.3 mg/kg Te <17.0 µg/kg Al <43.7 µg/kg I 41.3 µg/kg Si <191 mg/kg Cs <0.308 µg/kg P 50.6 mg/kg Ba <2.09 µg/kg S <9.14 mg/kg La <0.209 µg/kg K 3.65 mg/kg Ce <0.168 µg/kg Ca <3.48 mg/kg Pr <0.123 µg/kg Sc <3.52 µg/kg Nd <0.608 µg/kg Ti <60.7 µg/kg Sm <0.675 µg/kg V 203 µg/kg Eu <0.176 µg/kg
11, : 4355 续表 1 Cr <0.890 µg/kg Gd 4.24 µg/kg Mn <1.74 µg/kg Tb <0.0728 µg/kg Fe <1.16 µg/kg Dy <0.328 µg/kg Co <0.521 µg/kg Ho <0.0738 µg/kg Ni 100 µg/kg Er <0.236 µg/kg Cu <0.689 µg/kg Tm <0.0660 µg/kg Zn <3.82 µg/kg Yb 11.6 µg/kg Ga <1.19 µg/kg Lu <0.118 µg/kg Ge <5.48 µg/kg Hf <0.460 µg/kg As <5.85 µg/kg Ta <0.0945 µg/kg Se <64.5 µg/kg W <0.354 µg/kg 续表 1 Br 410 µg/kg Re <0.286 µg/kg Rb 12.2 µg/kg Os <0.784 µg/kg Sr <1.24 µg/kg Ir <0.160 µg/kg Y <0.481 µg/kg Pt <0.491 µg/kg Zr 78.7 µg/kg Au <0.416 µg/kg Nb <0.349 µg/kg Hg <1.24 µg/kg Mo <1.32 µg/kg Tl <0.150 µg/kg Ru <0.786 µg/kg Pb <0.216 µg/kg Rh <0.144 µg/kg Bi <0.148 µg/kg Pd <0.814 µg/kg Th <0.197 µg/kg Ag <0.325 µg/kg U <0.127 µg/kg 1 Fig.1 Results of semi-quantitative fitting 4.2 药品的方法学研究 ICP-MS, [22],,, 5 结论 ICP-MS,, ICP-MS,,, ICP-MS,, ICP-MS 参考文献 [1],,.
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