2008 3 EV71 19 16 84.2% EV71 EV71 RNA mir-296 EV71 EV71 HBoV1 NP IFN HBoV1 NS1 NS1-70 NF-κB HBoV1 VP2 RIG-I Journal of Immunology,Journal of Virology, ACS Nano, Biomaterials 30 8 6.83 Nature ACS NanoBiomaterialsJIVJI SCI 136 2018 71 Enterovirus 71EV71 RNA RNA PicornaviridaeEV71 3 EV71 1969 EV71, 2016
246 220 EV71 2005 Allander [1] Human BocavirusHBoV 4 HBoV1-4 HBoV1 HBoV2-4 HBoV2 HBoV3 2 4 HBoV HBoV B19 973, : ( EV71 1 RNA mir-296 EV71 microrna mir-296 EV71 mir-296 EV71 mirna Zheng et alj Virol., 2013, 87, 5645-5656 4.663 1) B3CVB3 EV71CVB3 CVB3(Zhang et al. J Virol. 2013, 87, 12407-124214.663) 2) EV71 EV71 2C IKKβ NF-κB 2C (Zheng et al, 2011, J Immunol. 187, 2202-2212 4.856)
HBoV1 1HBoV1NPIFN HBoV1 NPIRF3IFN regulatory factor 3 IRF3IFNIFN(Zhang et al, 2012, J immunol 189,144-1153, 4.865) 2HBoV1NS1NS1-70NF-κB HBoV1NS1NS1-70p65 p65nf-κbnf-κb 3HBoV1VP2RIG-I HBoV1 VP2 RNF125Ring finger 125, RIG-I E3 RIG-I IFN ( Luo et al, 2013, J immunol, 191,660-669 4.865) Journal of Immunology HBoV1 HBoV1 () 1 (QDs) (Zhang et al.,acs Nano. 2013 28:3896, 13.942) Chemical Research in Toxicology(ACS) Nanomedicine Zheng et al., Nanomedicine, 2013,8: 1225, 4.727 2 BacMam Aptag gp64 AcV5,, Biomaterials Wen et al., Biomaterials, 2014, 35:2295 8.402 Journal of Immunology, Journal of Virology, ACS Nano, Biomaterials 308 6.83Nature ACS NanoBiomaterialsJIVJI SCI136 1
RNA mir-296 EV71 RNA mir-296 Nature HBoV1 HBoV1 Quantum-dotsQDs ACS NanoBiomaterials (QDs) (Zhang et al.,acs Nano. 2013 28:3896, 13.942) Chemical Research in Toxicology(ACS) Nanomedicine Zheng et al., Nanomedicine, 2013,8: 1225, 4.727
1 2 3 4 5 // Human microrna hsa-mir-296-5p suppresses Enterovirus 71 replication by targeting the viral genome/ Journal of Virology/ Zhenhua Zheng, Xianliang Ke, Meng Wang, Siyi He, Qian Li, Caishang Zheng, Zhenfeng Zhang, Yan LiuHanzhong Wang* Enterovirus 71 2C protein inhibits TNF-α mediated activation of NF-κB by suppressing IκB kinase β phosphorylation/ The Journal of Immunology/ Zhenhua Zheng, Hongxia Li, Zhenfeng Zhang, Jin Meng, Da Mao, Bingke Bai, Baojing Lu, Panyong Mao, Qinxue Hu*, Hanzhong Wang* Human astrocytic cells support persistent Coxsackievirus B3 infection/ Journal of Virology/ Xiaowei Zhang, Zhenhua Zheng, Bo Shu, Xijuan Liu, Zhenfeng Zhang, Yan Liu, Bingke Bai, Qinxue Hu, Panyong Mao*, Hanzhong Wang* Human bocavirus NP1 inhibits IFN-β production by blocking association of IFN regulatory factor 3 with IFNB promoter/ The Journal of Immunology/ Zhengfeng Zhang, Zhenhua Zheng, Huanle Luo, Jin Meng, Hongxia Li, Qian Li, Xiaowei Zhang, Xianliang Ke, Bingke Bai, Panyong Mao, Qinxue Hu*, Hanzhong Wang* Human bocavirus VP2 upregulates IFN-β pathway by inhibiting ring finger protein 125 mediated ubiquitination of 4.663 4.856 4.663 4.856 4.856 (xx xx xx ) 2013, 87, 5645-5656 2011, 187, 2202-2212 2013, 87, 12407-1242 1 2012, 189, 1144-1153 2013, 191, 660-6 69 2013.3.6 2011.8.1 2013.9.1 1 2012.6.2 7 2013.6.1 4 SCI 52 57 22 32 8 8 18 25 7 11
6 7 8 retinoic acid inducible gene-i/ The Journal of Immunology/ Huanle Luo, Zhengfeng Zhang, Zhenhua Zheng, Xianliang Ke, Xiaowei Zhang, Qian Li, Yan Liu, Bingke Bai, Panyong Mao, Qinxue Hu, Hanzhong Wang* Encapsulating quantum dots into enveloped virus in living cells for tracking virus infection/ ACS Nano/ Yuan Zhang, Xianliang Ke, Zhenhua Zheng, Cuiling Zhang, Zhenfeng Zhang, Fuxian Zhang, Qinxue Hu, Zhike He, Hanzhong Wang* Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking/ Biomaterials/ Fuxian Zhang, Zhenhua Zheng, Shulin Liu, Wen Lu, Zhenfeng Zhang, Cuiling Zhang, Peng Zhou, Yuan Zhang, Gang Long, Zhike He, Daiwen Pang, Qinxue Hu, Hanzhong Wang*. In vivo study of immunogenicity and kinetic characteristics of a quantum dot-labelled baculovirus/ Biomaterials/ Meng Wang, Zhenhua Zheng*, Jin Meng, Han Wang, Man He, Fuxian Zhang, Yan Liu, Bin HuZhike He, Qinxue Hu, Hanzhong Wang* 13.94 2 8.402 8.402 2013, 7, 3896-3904 2013, 34, 7506-7518 2015, 64,78-87 2013.4.8 2013.7.5 2015.6.2 0 18 20 10 11 1 1 136 165
2008-01-01 2015-12-31 90% 2009-09-01 2015-12-31 microrna mir-296 EV71 mir-296 EV71 mirna ( 1) EV71 2C IKKβ NF-κB 2C ( 2) 8 34567 2008-09-01 2015-12-31
(QDs) 6 Chemical Research in Toxicology(ACS) 7 2010.9.1 2015-06-30 2010-07-01 2011-7-31 EV71 2C IKKβ NF-κB 2C 2