Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. * 1349 *
295,705 272,040 241,910 214,224 153,370 57,018 55,542 51,345 45,026 41,371 (3,113) (2,862) (2,332) (2,720) (1,057) 53,905 52,680 49,013 42,306 40,314 (8,031) (7,133) (7,475) (5,138) (5,034) 45,874 45,547 41,538 37,168 35,280 52,408 49,572 45,936 39,661 36,296 (6,534) (4,025) (4,398) (2,493) (1,016) 45,915 45,367 41,538 37,168 35,280 52,449 49,392 45,936 39,661 36,296 (6,534) (4,025) (4,398) (2,493) (1,016) 83,862 78,710 65,524 63,433 53,356 0.0568 0.0537 0.0498 0.0430 0.0393 1,246,809 1,145,134 1,120,753 1,020,265 824,481 (331,107) (252,652) (247,699) (254,425) (148,062) 915,702 892,482 873,054 765,840 676,419 897,149 872,390 843,554 732,630 650,975 18,553 20,092 29,500 33,210 25,444 915,702 892,482 873,054 765,840 676,419 1
295,705,000272,040,000 9% ALA Hemoporfin 29% 137% Doxorubicin liposome 287,165,000 97.11% 6%269,960,000 58% 29% 9% 2
36,602,000 23,838,000 9%12% 57,018,00055,542,000 3% 20,783,000 37% 32,999,000 2,878,000 7,670,000 9,541,00017,806,000 7 3
43,966,000 1%44,379,000 15% 16% 146,737,000 8% 158,932,000 50%58% 31,619,000 43% 22,098,000 546,000 250,000 4
3,113,000 9% 2,862,000 15% 25% 16.5% 45,874,000 45,547,000 1% 52,408,000 49,572,000 6% 5
Fc(rhTNFR(m):Fc) I (ADC) CD30 -MCC- DM1CD30-DM1 HPV II 6
I II II 65% 40 LED IV 7
FDA HPV 96% 8
(ADC) Wnt 9
CFDA GMP FDA GMP 10
50,000,000 300,000,000 60,000,00020% 200,000,000 11
20,000,00055% 150,000,000 60,000,000 4.35% 40,000,000 4.35% 10,000,000 4.35% 40,000,000 4.57% 12
492,838,000 735 621 67,238,000 50,694,000 13
142,000,000 0.10 H 1.70 233,909,000 185,575,000 20,000 1,207 445 10,000 20,000 CD30 30,000 20,000 85,575 185,575 1,207 445 445 14
(a) 571 XV 7 8(b) 352 (c) 57,886,430 9.93% 6.27% 22,312,860 3.83% 2.42% 19,260,710 3.30% 2.09% 1,170,000 0.20% 0.13% 870,000 0.15% 0.09% 15
XV 2 3 336 139,578,560 23.94% H 70,564,000 20.75% 22.77% 139,578,560 23.94% 22.77% H 70,564,000 20.75% 156,892,912 26.91% 17.00% 80,000,000 13.72% 8.67% 30,636,286 5.25% 3.32% Invesco Hong Kong Limited 30,636,286 5.25% 3.32% H 25,236,000 7.42% 2.73% 16
17
A H 27,000,0000.10 A A A H A A i)ii) iii) A A A 18
a) b) c) d) e) f) g) h) 19
6 295,705 272,040 8 (36,602) (23,838) 259,103 248,202 7 20,783 32,999 8 (43,966) (44,379) 8 (146,737) (158,932) 8 (31,619) (22,098) 8 (546) (250) 57,018 55,542 (3,113) (2,862) 53,905 52,680 9 (8,031) (7,133) 45,874 45,547 41 (180) 45,915 45,367 52,408 49,572 (6,534) (4,025) 20 45,874 45,547 52,449 49,392 (6,534) (4,025) 45,915 45,367 11 0.0568 0.0537 25 44
12 29,783 30,178 12 308,309 314,638 12 4,937 4,937 12 12,966 13,927 12 48,851 50,073 11,436 4,992 13,775 13,775 13 4,044 4,708 434,101 437,228 36,859 39,667 14 239,711 170,816 31,842 22,521 10,688 3,215 492,838 468,144 770 3,543 812,708 707,906 1,246,809 1,145,134 21
15 12,164 13,323 16 6,438 5,521 138,142 81,367 2,634 11,536 1,116 3,690 3,690 17 150,000 140,000 15 6,503 7,635 318,943 239,329 331,107 252,652 92,300 92,300 804,849 780,090 897,149 872,390 18,553 20,092 915,702 892,482 1,246,809 1,145,134 25 44 22
24,705 32,844 (3,113) (2,862) 1,762 1,565 (4,055) (10,698) 19,299 20,849 (15,925) (30,341) (348) (941) (137) (2,225) (13,775) 174 320 (939,900) (777,000) 946,495 782,906 (9,641) (41,056) 4,995 4,996 50,000 40,000 (40,000) 14,995 44,996 24,653 24,789 468,144 511,284 41 (180) 492,838 535,893 25 44 23
92,300 412,293 46,150 292,905 (94) 29,500 873,054 49,572 (4,025) 45,547 (180) (180) 49,572 (180) (4,025) 45,367 5,551 5,551 (46,150) (46,150) (46,150) 5,551 (40,599) 92,300 412,293 46,150 296,327 (274) 31,026 877,822 92,300 412,293 46,150 322,042 (395) 20,092 892,482 52,408 (6,534) 45,874 41 41 52,408 41 (6,534) 45,915 4,995 4,995 (27,690) (27,690) (27,690) 4,995 (22,695) 92,300 412,293 46,150 346,760 (354) 18,553 915,702 25 44 24
1. 5,295,000 5,295,000 53,000,000 1.00 53,000,0000.10 530,000,000 198,000,000 0.10 H18,000,000 H 71,000,000 142,000,000 0.10 H1.70 85,200,000 0.51 71,000,000 0.10 92,300,000 H 25
1. 65% 69.77% 84.68% 50.04% 55% 100% 308 2. 34 26
3. (a) (i) (ii) 9 15 9 9 15 27
3. (a) 9 15 30,178 30,178 314,638 314,638 4,937 4,937 13,927 13,927 50,073 50,073 4,992 4,992 13,775 13,775 13,775 (13,775) 4,708 4,708 437,228 437,228 39,667 39,667 170,816 170,816 22,521 22,521 3,215 3,215 468,144 468,144 3,543 3,543 707,906 707,906 1,145,134 1,145,134 28
3. (a) 9 15 13,323 13,323 5,521 5,521 81,367 (1,851) 79,516 1,851 1,851 1,116 1,116 3,690 3,690 140,000 140,000 7,635 7,635 239,329 239,329 252,652 252,652 92,300 92,300 780,090 780,090 872,390 872,390 20,092 20,092 892,482 892,482 1,145,134 1,145,134 9 15 29
3. (a) (i) 9 9 39 2018 1 1 13,775,000 9 9 9 (7.2.15) (7.2.26) 9 9 9 2018 1 1 2018 6 30 6 30
3. (a) (i) 9 9 (ii) 15 15 15 18 15 81,367 (1,851) 79,516 1,851 1,851 15 31
3. (a) (ii) 15 15 15 15 (iii) 9 32
3. (a) (iii) (b) 16 17 23 10 28 33
4. 5. 5.1 5.2 6. 287,165 269,960 7,764 1,621 776 459 295,705 272,040 34
7. 9,541 17,806 (a) 2,878 7,670 (b) 6,595 5,906 1,762 1,565 7 52 20,783 32,999 (a) (b) 80% 80% 35
8. 395 395 1,670 1,901 1,098 765 661 347 2 (73) (7,530) 17,195 13,135 23,781 20,421 (100) (314) 23,681 20,107 376 71 5,534 1,884 10,288 10,013 67,238 50,694 (13) (534) (163) (229) 67,062 49,931 79,260 103,828 26,343 22,661 4,387 4,217 41 4,107 21,552 23,663 259,470 249,497 36
9. 15% 15% 25%25% 16.5% 16.5% 14,475 5,586 (6,444) 1,547 8,031 7,133 10. 11. 52,408 49,572 923,000 923,000 0.0568 0.0537 37
12. 37,356 482,955 8,937 20,968 64,085 18,002 137 448 (1,770) 37,356 499,187 8,937 21,105 64,533 7,178 168,317 7,041 13,359 395 23,781 1,098 1,670 (1,220) 7,573 190,878 8,139 15,029 4,000 653 29,783 308,309 4,937 12,966 48,851 38
12. 37,356 447,551 8,937 15,116 62,214 24,748 2,580 1,255 (13,417) 37,356 458,882 8,937 17,696 63,469 6,388 143,318 5,380 9,711 395 20,421 765 1,901 (13,026) 6,783 150,713 6,145 11,612 30,573 308,169 8,937 11,551 51,857 13. 4,044 4,708 39
14. (a) 197,197 116,143 (1,066) (405) 196,131 115,738 (b) 43,580 55,078 239,711 170,816 (a) 1 4 170,584 95,301 30 6,017 14,504 30 60 17,159 5,190 60 90 945 19 90 1,677 1,041 815 88 197,197 116,143 (b) 40
15. 16,422 18,713 2,245 2,245 18,667 20,958 (6,503) (7,635) 12,164 13,323 16. (a) 6,438 5,521 (a) 30 5,056 4,310 31 60 137 809 61 90 163 243 90 952 30 130 129 6,438 5,521 41
17. (a) 100,000 100,000 (b) 50,000 40,000 150,000 140,000 (a) 60,000,000 4.35% 40,000,000 4.57% (b) 40,000,000 4.35% 10,000,000 4.35% 3,113,000 2,862,000 42
18. (i) 17,502 5,804 7(a) 470 (ii) 7,140 2,545 3,548 670 10,688 3,215 3,690 3,690 43
19. 44