µ γ α γ α µ α µ γ Ig/Ig-TCIC
1 immune immunity immunis 10 998~1022 19 Edward Jenner Jenner Louis Pasteur 1880 Elie I.I. Metchnikoff (1883), P.P.Emile Roux A.E.J.Yersin (1888) Emil A. Von Behring Pfeiffer 1894 Border 1895 Pfeiffer 20 Von Pirquet Schick hypersensitivity allergy Ehrlich 1901 Donath Landsteiner 1907 Dameshek 1938 autoimmunity autoimmune tolerance AID immune tolerance Owen 1945 Medawar 1953 immunologic homeostasis DNA immunologic serveillance
70 [1-17] 1. 10 Biological response modifier BRM BRM 4 IL-2-2 LAK tumor infiltrating lymphocyte TIL 18 MHC 2. 70 A CsA 80 FK-50b 19 B 80 T 20 3. 21 HIV HIV 22 4. IgE 5.
23 6. 24 2 immune network Jerne 1974 [25] Burnet 1955 V V [26] [27] 1 T B idiotype Id 2 Id antiidiotype AId 3 4 Id Id 5 Id V AId Id AId Ab2 Ab1 Id Id AId Ab2 AId Ab2 AId AId Ab1 Ab2 6 1 AId Schreiber 1991 O- AId [28] Su SD 1992 A AId AId Kennedy 1984 AId AId HBs [29] 70 Attansis 1991 CD4 CD4 AId CD4 HIVgp120 [30] RSV HSV-
1 1.1 (HRP) RZ>3.1 Sigma 1.2 IgG IgM IgG IgA 1.3 IgM IgG IgA C3 1.4 IgM IgG IgA IgG IgM IgG IgA 1.5 1.5.2 1.7 2 2.1 401 2.2 531 1995 246 145 63 39
38 40 2.3 97 1995 HAV - IgM 2.4 108 2.5 125 2.6 126 2.7 HBV 57 1990 HBV 3. 3.1 M-3550 Bio-Rad 3.2 CX9 Beckman 3.3 ASC1800 Chairon 3.4 BA 210 Sartorius
3.5 LXJ- 4. -20 4.1 Ig/Ig-TCIC 4.1.1 Ig/Ig-TCIC ELISA µ γ α IgG 0.1ml 4 ph7.4 0.01mol/L PBS-T 3 0.1ml 2% 37 1h 0.1ml 5 1:75 4 µ γ α γ µ α α µ γ 4.2 9 Ig C3 Ig C3 3.5%PEG 3000rpm/min 20min PEG 1 Ig C3 Ig C3 Ig C3 4.3 ALT Meckman 4.4 T3 T4 ft3 ft4 ASC1800
5., t 2 Public Domain Software for Epidemiology and Diseases Surveillance (Epi Info Version 5.01b)
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