1 metastasis bone metastasis 2 1
70% 3 100 80 60 % 40 20 0 95 ~ 100% 65 ~ 75% 65 ~ 75% 30 ~ 40% 4 2
cytokines RANKL Skeletal-Related EventsSREs 5 RANKL 4. 1. cytokines 3. RANKL RANK RANKL 2. RANKL 3
2 radiotherapy 88.5% 6 4
4 Denosumab Bisphophonates 5
XGEVAdenosumab 120 mg denosumab RANKL 5 RANKL 6
5 4 1120 7 8 9 7
5,8 8 16% 10 16% 10 5, 11-13 2 ~ 3 6 D 8
5, 11-15 2 ~ 3 6 3 9
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