Bis marck
aging Senility
DNA DNA DN A
DNA Orgel DNA RNA DN A RNA H arman Bjoxk st en
T programeol cell death PCD
X
P
vitb
ml
T TR H P T H Ca P T H
T T T
R Bocon N ascher Geriatrics
A
genetic program theory modifier genes theory
codon restriction theory DNA DNA DNA DNA
cross linkage theorr free radicals DNA DNA DN A Y point mutation chromosomal muta tion genomic mu tation tran si tion tran sversion insertion deletion
basesubstitution frame shift mut ation soma tic mutation theory lipofuscin
DNA H R R H
R H free radicals O O H O H H R RO ROO L L O L O O O O H reactiveoxy gen species ROS O O H O O H O O H O Poeggeler H O O H nmh O O H DM PO O H DMPO O H O H O OO O
O O DNA N D NMDA Ca Ca O H O Peruche IFNTNF TNF burst
eryth rocyte diformability micro plugs DNA MDA H O Kainate
DNA
apoptosis necrosis programed cell edath PCD ROS ROS
ROS ROS burst ROS P ROS DNA H Omol L mol L H O H O TN F IFN GM CSF IL DN A DNA
DN A c myc c fos c myc c myc bcl c myc c fos bcl bcl Kda P P
NDA DN A mtdn A bp DN A mtdna mtdna r RNA S S trn A B C A T P NAD H ND NDND L M tdna mtdn A mtdna DNA ndanmtdna mtd
N A ndna mtdn A mtdn A mtdn A mtdn A mtdn A mtdna mtdna mtdn A mtd N A mtdna mtdn A
mtdna mtdn A OSP H OS mtdna Lerbe Lerbe s hereditary optic neuropathy mtdna G A NAD H ND mitochondrial mypathy encephalopathy lctic acidosis stroke like episodes mtdn A trnaleu A G mtdna
mtdn A mtdn A mtdn A OXP H OS mtdna mtdna mtdna mtdn A mtdn A mtdna mtdna mtdna mtdn A mtdn A mtdn A OXP H OS OXP H OS mtdn A
mtdn A Wallace kbkb mtdna OXP H OS mtdna M tdna mtdna A T Pase D kb mtdna mtdn A mtdna OXP H OS M tdna Parkinson PD Alzheimer AD H untington HD OXP H OS
mtdn A PD PD I I mtdna mtdn A kb mtdna AD mtdn AT OXP H OS Parker AD IV OXP H OS AD OXP H OS mtdna AD mtdn A OXP H OS H D HD IV I HD
H D mtd N A M tdna OXP H OS OXP H OS mtdn A k bmtdn A L O r RNA NDcytb RNA mtdna mtdna OXP H OS mtdn A mtdna A G trnaleu ATP M tdna mtdn A
OXP H OS mtdna ATP mtdna PCR Southern Q mtdn A mtdna mtdn A telomere telomer aserna CD T
B T B B T B
B T
T K T T T H T B T H T M T B IgG IgA IgG IgA T s B IgM IgD IgE M Walford
DN A HLA HLA A B C D Dr HLA A HLA B HLA Dw HLA B HLA Dw Imu ran B poly anions E T T
maxi mun life span
Caenorhabditis elegan s age Age C elegans H O C elegans C elegans clk daf daf Daf C ele gans Clk Clk C elegans Clk daf clk C elegans daf clk senescence associated gene SAG
DN A senescent cell derived inhibitor of DNAsynthesis Werner WRN WRN E Alzheimer Disease AD EF EF SOD Rose
SOD me latonit M T M T MT MT
MT M T MT MT M T MT M T MT M T MT MT m R N A MT MT M T DNA M T MT MT MT
Fe I Zn Cu Mn Se CrMoCoFSrSnNi v Zn Mn Se Cr GS H pk H DL CSOD IgA Zn Mn Se Cr Co Ge V Cr Mn Ni Zn Se
Zn Mn Se Cu DN A
m RNA cdna cdn A DNA cdna Northern Northern Norther n YAC cosmid phage YAC DN A Northern YAC cosmid phage cdna cdn A cdna DN A cdn A PCR cdna
cdna cdna DN A PCR cdn A DNA DNA cdn A DNA CpG NotI Zoo blot DNA cdna cdna DN A DN A DN A DN A
open reading frames technology of the repertoire of antibodies dis played on phages by passing immunization and hy bridoma HBsAG H TV ScFv
ribozyme mrn A HBV HCV HIV RNA RNA
SIgA
T N K IL T B NK NK N K NK N K T T T T CT L
THT B B cytokin IL CSF IF N TNF TGF LI F
C X
Mycoplasma Pneumonia MP X
Noscomial Pneumonia NP
X g G g mg g g gg
g G mg
Osteoporosis I
Bone Re modeling CT P T H O H D CT C P TH OH D P T H O H D P T H C C T
I IGF I IGF I O H D IGF I P T H Ca P K BMD
D O H D D D VDR BBA A BMD TG F I
P T H T T D D O H D O H D P T H mg P TH
D K Ca O H D
cm mm cm Colles BMD DS
X BMD I AK P A KP AK P
AKP A KP A KP BGP O H D BGP BGP PG P BGP I PICP PICP P ICP PICP H O P h d H OP H O P H OP H O P
H OLG H OP T RA P T RAP T RAP PYr I N NTX H OP mmol L mg dl D P Ca D
D h h X X X SPA
BMC g m BW cm BMD g cm X DEXAX BMC AREA BMD DEXA QCT CT QC T X U SA DXA
I II D K P T H C T O H D TG FB mg d mg
mg d mg mg Livial mg CT P T H Vit D O H D Ca mg d CT Ca P T H Vit D Ca CT CT U U
Elcatonin CT U U U Ca U d CT Miacalcic U U U ml C T CT C T CT Vir D Ca P TH Vit D O H D Vit D Ca Vit D VD O H D g D Alfacalcidol O H D
O H D g d Ca mg g Ca g g g g g D mg Vit D U
P T H EH T P Bonefos mg mg Disoduum E tidrona temg mg d mg ml Ipriflavone C T Osten CT mg CT
Oxandrolone mg d mg mg Vit K mg d mgvit D Ca Vit D
Ca P Vit D Ca P ml Ca mg
Vit D CT Ca Vit D P T H CT Vit D
Alzheimer AD AD AD
AD AD AD AD AD Vascular Dementia VD Multl infarct Dementia MD AD Down AD apoead apoe apoe AD
Corder AD apoe AD SP NF T AD Scapie Kwru Creutzfeldt Jacob C J AD AD AD AD H T P
AD AD AD N F T SP AD SP NF T SP SP IgG IgG
c s CT MRI prsyo phrenia
Paxa bcknn AD AD CT AD SP NF T SPNF T SP NF T SP NF T DSM IV
WH O ICD NICFS ADRDA AD NF T tau phospho ryltedneu rofilament P NF P H F CT MRI PE T AD M ABP ABP AD
FDA AD t acrine t E donepezi aluminum chelating agentdeferoxam ine NSAIDS AD AD
AD AD
mm
Plummer Vinson MCV m g dl mg ml
g g C mg g dl g d mg
B DN A S VitB B VitB PAS VitB B mg B
MCV m ng ml ng ml B Pg ml mg B B g g
h
B X CT
Flunariaint
arteriosclerosis atherosclerosis AS
fatty Streak AS VLDL HDL LDL LDL ch Tc
TC LDL Ch CH D AS C HD Tc CHD CH DL ch CH D TG CH D AS AS AS HDL HDL HDL LDL HDL
CHD VLDL A TXA TXA PGI TXA AS AS
AS X CT
A P TCA
mg
mg dl T C TG PL FFA FF A LP HDL L P LDL L P VLDL pre LP CM Apo A B C D E F G H J H DL H DL H DL Apo A Apo A I Apo A II Apo B Apo BApo B Apo C Apo CI Apo C Apo C
AS CHD CH D NEP CHD TC mg dl mg dl mg dl CH D HDL C mg dl H DL C C HD TG mg dl mg dl mg dl mg dl LDL C mg dl mg dl TC mg dl TG mg dl CH D H DL C mg dl H DL C
T C mg dll TG mg dl AS TC C HD MRFI T T C mg dl C HD TC mg dlmg dl mg dl COX C HD TCmg dl mg dl CH D TC mg dl TC CHD LDL TC LDL C LDL C mg dl mg dl mg dlmg dl CH D C HD LDL C
H DL HDL C mg dl mg dlmg dl CH D HDL C CHD TG CH D TG CM VLDL LDL H DL C AS CH D LDL C H DL C TG C HD a LP a C HD LDL Apo a L P a CH D L P a CH D LP a LDL CH D LP ach D L P a L P a mg dl CH D mg dl
L P a LP a AS Apo AI Apo A II AS Apo B LDL AS Apo AI Apo B TC TG TG TC TG TC
TC LDL TG Apo B HDL Apo AI T C H DL C TC LDL T C mg dl C C TC TC C LDL C HDL C e e C
E PQ Ce D H A Ce TC LDL C TG mg TC gkcal LDL C mg dl TC LDL CTG TC H DL C H DL C g d TC H DL C TG T C H LD C HDL C HDL C TC TC TC TG HDL C TC LDL C H DL C TG
T C TC TG H DL C TG H DL C TC H DL C TG H DL C TC HDL C TC mg dl TG mg dlh DL C mg dlldl C mg dl HDL C TC T C TG TC TG H DL C TC H DL TC
Fredrick son W H O Iab H DL C Targier Apo AI Apo C LACT LP L Apo C AS C HD TC TG T C TG HDL C H DL C
TC mg dl LDL C mg dl F H LDL C CH D F H LDL LDL TC mg dl T C mg dl LDL C mng dl F H T C mg dl C HD AS TG TG mg dl LP L FCH CHD TC TG VLDL Apo E Apo E Apo E VLDL LDL
CM VLDL TC TG CH D VLDL Apo EApo E Apo E LP L Apo C CM CM TG TG CM LP L Apo C HDL C H DL C H DL C H DL C Apo B LP a C HD
TG CM VLDL CM CM CLDL TC TG HDL C LDL C LDL C F riedewald TG mg dl LDL C LDL C T C H DL C TG mg dl TC H DL C TG mmol L b H DL VLDL LDL CM
L PL LP L CM LP L TG C HD TC F H CM VLDL VLDL F H TC X mm mm LDL CM TG TG CM TG mg dl
AS CH D AS CHD kpa mm Hg H DL C mg dl HDL C mg dl NCE P LDL C
kg d d d mg d mg d g
TG TC HDL C h CH D AS CHD
Chesty amin ColestipoL Nicotinic Acid Inositol Nicotinate Acipimos Olbe tam Begafi brafe Gemfibrate Lopid Fenofibrate Ciprofibrate E tofylline Clofibrate Clofibrate P robucol HM CoA A Lovast afin Simvsta tin pravastitn Fluvsta tin T C
TC LDL LDL TC H DL C g d VLDL TG gd LDL LDL C H DL C TC LDL
d g Q T HDL C Elastase TC d U TC TG HMG CoA HMG CoA LDL LDL mg mg TC TC LDL C TG HDL C ALT CPK
H MG CoA T C LDL C TG H LD C TGTC VLDL TG VLDL H DL H DL TG TG T C LDL C H DL C gd g d gd g d ALT CK H MG CoA CoA VLDL LP L
CM gd T C TG LDL C H DL C d g TG HDL C TG TC AS d g TG TC HDL C TG Omega EPA DH A TG TG g d
g d AS L P a L P a
V
E
A
A C E
l
kg
E C
E A E A
g g g g g
g
mg A D E B B B C A D E B B
B B C ml
C
E A C A C
D
AA A A A A A D D D D D D D E E E
K K K K B B B B B B B B B
B B C C C
A D E K G G G
G A
DNA RNA
mg H gtrain mg mg mg Proscar
B M M M
A
B B B B DNA C C
BB B A D E
Hunvifz
g g g g
C B B
B B C A B C
g g g g g g g g g g
g g g g g g
g g g g g g g g ml g g
g g g g g g g
g g g g g g g g g g g ml ml g
g g g g g g g ml ml g g g ml g g g g g
g g g g g g g ml g g
g g g cm cm g g
g g
g g g g g
g g g g g g g g g
g g cm cm g ml g
g g g
g g g g ml
g
g g g g
g g g g g g g
g g g g g g
g g g
E
g g g g g g g g g
ph p H
ph
E
A B A B A B C
A C B B
A D E