1 Dottikon 213 213.3 Nitenpyram Dottikon Exclusive - Synthesis AG 15 218.2 11.4mg 213 213.3 Nitenpyram Tablets - Novartis Sante 16 218.2 Animale S.A.S. 57mg Nitenpyram Tablets Novartis Sante 213 213.3-17 218.2 Animale S.A.S. Compound Ointment Clotrimazole Schering-Plough Animal Health Corp. 213 213.3-18 218.2 Canada 1g:2g(2 ) Monensin Premix Biovet Jiont Stock Company 213 213.3-19 218.2 2
2 5 Xidingchong an Nitenpyram 27.72 C 11 H 15 ClN 4 O 2 E N-(6- -3- )-N- -N'- -2- -1,1- C 11 H 15 ClN 4 O 2 98.% 1 2 1 2 3 98 5μμμμμμm 96% 25μμμμμμm 75%.5g 5ml 56 ph 5.8 7.8.5g 5ml 1 91 NOA 4393 2g 25ml 3
1.g/L 1ml 1min NOA 4393 1mg 1ml 1ml 1ml 1.g/L 36 1.g/L - (7 : 3) A 1.g/L B 1.g/L C 22nm1.5ml 5 l NOA 4393 1.1.3% A % B % C % 2 8 3 33 8 59 32 1 37 1 38 2 8 48 2 8 CGA 364185(NAMI) NOA 436315 OXIM 1% 1ml.228mg CGA 364185 1mg 1ml 1% 8ml 1ml 5ml 1% 2 l CGA 364185 NOA 436315 CGA 364185 NOA 436315 1.65 1.22 CGA 364185.2% NOA 436315.84.2%.2% 2.%.5%.2g 5μμμμμμl 2mg 1ml 5ml 25μμμμμμl 25μμμμμμl 81 4 C 8 6 C 16 C 15 C 2 C 7 C15 4
.5% 78 4.1% 1.g 8.1% 75 36 4 A B 1% C 22nm 1.ml 1% 1ml.228mg 2μμμμμμl 15 1.8 A % B % C % 1 2 15 5 8 4 25 2 55 5 9 1 51 1 55 1 56 1 65 1 1% 1ml.228mg 2 l 2 8 C 3 Dottikon (Dottikon Exclusive Synthesis AG) Hembrunnstrasse 17, CH-565 Dottikon,Switzerland) 5
1 A 6
2 B 7
3 A B 5:5 8
1) NOA 43 93 2) CGA 364185(NAMI) N- 6- -3- -N- -N- - N- 6-3- -N- -2- - 3) NOA 436 315(OXIM) N- 6 - -3- -N- - 2- -N - - 2- - 9
Xidingchong an Pian Nitenpyram Tablets C 11 H 15 ClN 4 O 2 9.% 15. % 1 114mg1ml 1mg 1ml 33 5μμμμμμl GF 254 - -25% 75 : 25 : 5 (254nm) 2 114 1ml 1 3 57mg 1 5-26 269.5nm 1ml 11.4μμμμμμg 75% 79 B 6.% NOA 4393 228mg 25ml 1.g/L 1ml 1min NOA 4393 1mg 1ml 1ml 1ml 1.g/L 1ml 25ml 1g 36 1.g/L - (7 : 3) A 1.g/L B 1.g/L C 22nm 1.5ml 5 l NOA 4393.3% A % B % C % 2 8 3 33 8 59 1
32 1 37 1 38 2 8 48 2 8 CGA 364185(NAMI) CGA 28846(PMEA) NOA 436315 OXIM 1% 1ml.228mg CGA 364185 CGA28846 1mg 1ml 1% 1ml 5ml 1% 2 l CGA 364185 NOA 436315 CGA28846 1.66 1.22.55 CGA 364185 CGA28846 NOA 436315 CGA 364185 CGA28846 CGA 364185 4.5% CGA28846.6% NOA 436315 NOA 436315.8%.5% 1.%.5% RSi = PRSi 1 F/ PT C % PRSi PT C FNOA 436315.841 5 36 A B 1% C 22nm 1.ml 4 1% 1ml.228mg 2μμμμμμl 15 2. A % B % C % 1 2 15 5 8 4 25 2 55 5 9 1 11
51 1 55 1 56 1 65 1 2 1mg 11.4mg 5ml 1% 4ml 1min 1% 114mg 1ml 1% 1ml 5ml 1% 2 l 1-11 11.4mg 1 11.1kg - 57kg 57mg 1 57kg 57mg 2 1 1 1 1 4 1kg 2 3 4 25 1 11.4 mg 2 57 mg 3 (Novartis Sante Animale S.A.S.) B.P.224, F-6833 Huningue, France 12
1) NOA 43 93 2)CGA 364 185 NAMI N- 6- -3- -N- -N- - 3)CGA 288 46 PMEA N- 6-3- -N- -2- - 4)NOA 436 315 OXIM 6- -3- N- 6 - -3- -N- - 2- -N - - 2- - Capstar Nitenpyram Tablets 13
Xidingchong an Pian 15-3 6 95% 1%.5-2 4 8 1 2 9% 1-11 11.4mg 1 11.1kg - 57kg 57mg 1 57kg 57mg 2 1 1 1 1 4 1kg 2 3 4 1 11.4mg 2 57mg 6 / 6 / 25 C 3 (Novartis Sante Animale S.A.S.) B.P.224, F-6833 Huningue, France 14
Nitenpyram Xidingchong an 2 8 C Dottikon (Dottikon Exclusive Synthesis AG) Hembrunnstrasse 17, CH-565 Dottikon,Switzerland) Capstar Nitenpyram Tablets Xidingchong an Pian 1-11 11.4mg 1 11.1kg-57kg 57mg 1 57kg 57mg 2 1 1 1 11.4mg 2 57mg 15
6 / 6 / 25 C (Novartis Sante Animale S.A.S.) B.P.224, F-6833 Huningue, France 16
Fufang Kemeizuo Ruan gao Compound Clotrimazole Ointment C 22 H 17 ClN 2 C 22 H 29 FO 5 9.% 11.%9.% 115.% 15mg 5ml 1ml.1mol/L ph8. [16.73g.523g 1ml ]5ml 1 2 5 1ml 1mg 2μμμμμμl G 15 2 - - 1:1:1 1 2 1:1 1:5 143 1 36 -.5mol/L ph 6.5 4:6 254nm 3 1.9 75±±±±7.5mg 1ml 2±±±±.2g 5ml 5ml 2ml 2 25rpm 1.45μμμμμμm 15μμμμμμl 5±±±±5mg 1ml 17
1±±±±1mg 25ml 5ml 25ml 2g 5ml 5.1mol/L ph 8. 1ml 5 121 7% 1 1mg 15kg 4 15kg 8 1. 2. 1. 2. 3. 4. 5. 6. 7. 7.5g: 75mg+ 22.5mg+ 7.5mg 2 25 2 Schering-Plough Animal Health Corp. Canada 3535 Route Transcanadienne Pointe-Claire, Quebec Canada H9R 1B4 18
TM (Otomax TM ) Compound Clotrimazole Ointment Fufang Kemeizuo Ruan gao - - 15kg 4 15kg 8 1. 2. 1. 2. 3. 4. 5. 19
6. 7. 7.5g: 75mg+ 22.5mg+ 7.5mg 2 25 2 Schering-Plough Animal Health Corp. Canada 3535 Route Transcanadienne Pointe-Claire, Quebec Canada H9R 1B4 15kg 4 15kg 8 7.5g: 75mg+ 22.5mg+ 7.5mg 2 25 Schering-Plough Animal Health Corp. Canada 3535 Route Transcanadienne Pointe-Claire, Quebec Canada H9R 1B4 2
Monengjunsu Yuhunji Monensin Premix 9.% 11.% A B A B.1g1 ml 56 ph 6. 9. A A+B A 9.% A B 95.% 15 8. 78 143 1g 5cfu 5cfu 1g 1cfu 14 36 - - 94 6.1 - - 95 v/v/w 2 3.8ml 2ml 98 52nm A B 1.25 A 1.4 B.9 A 1. 21
C/D 1.1 5mg 1ml 9% 2ml 15 9% 1μμμμμμl i = A ( i) W Q ( A) A A W P D D 1 i A B C/D A i A B C/D A (A) A W W Q A A P D D P =A+.28B+1.5C/D 1Kg 1 125g 1 12mg/kg 2 1 1 16 2 3 4 5 1g 2g 2 2 Biovet Jiont Stock Company No. 39 Petar Rakov ST 455 Peshtera,Bulgaria 22
2% (POULCOX 2%) Monensin Premix Monengjunsu Yuhunji K + Na + Na + 22 99% 1Kg 1 125g 1 12mg/kg 2 1 1 16 2 3 4 5 5 23
1g 2g 2 2 Biovet Jiont Stock Company No. 39 Petar Rakov ST 455 Peshtera,Bulgaria 26 MOMA72 185 1-6119155 1-6119156 2% (POULCOX 2%) Monensin Premix Monengjunsu Yuhunji 1Kg 1 125g 5 1g 2g 2 24
Biovet Jiont Stock Company No. 39 Petar Rakov ST 455 Peshtera,Bulgaria 26 MOMA72 185 1-6119155 1-6119156 25