ACTG CD4 HIV 355 1665 CD4 HIV CD4 HIV 3.8 46.081 4 CD4 4 4 3 1 4 4.65915.71543.6 10.0944.365710.063 CD4 HIV Matlab
1 1981 0 3000 AIDS, HIV CD4 HIV CD4 HIV HIV AIDS 3 HIV CD4 CD4 AIDS AIDS AIDS ACTG 1ACTG30 1 ACTG30 zdovudnelamvudne ndnavr 3 300 CD4 HIV 193A 193A 1300 4 4 8 CD4 HIV 4 600mg zdovudne 400mg ddanosne 600 mg zdovudne.5 mg zalctabne600 mg zdovudne 400 mg ddanosne600 mg zdovudne 400 mg ddanosne 400 mg nevrapne 1 1 4 CD4 3600mg zdovudne 1.60 400mg ddanosne 0.85.5 mg zalctabne 1.85 400 mg nevrapne 1.0 4 1
HIV CD4 HIV CD4 HIV HIV AIDS CD4 HIV 1CD4 CD4 [1] HIV CD4 mm 3 CD4 00-499/mm 3 AIDS CD4 00/mm 3 HIV HIV HIV HIV HIVHIV 1 1 ACTG30 3 300 CD4 HIV 1 txtxltexcel [] 355 1665 CD4 HIV HIV excel 100 HIV 6% 048440 1665 1 1 048440 CD4 HIV CD4 HIV 038340 3 8 CD4 HIV 4 CD4 HIV 3 40 CD4 HIV 4 CD4 HIV
1 1665 148438 1 4 CD4 HIV 0 CD4 HIV 4 38 CD4 HIV 40 CD4 HIV 04844150 4 41 CD4 HIV 40 CD4 HIV 50 0484 40 CD4 HIV 0 0 CD4 4 Log(CD4 +1) 4 CD4 CD4 CD4 3 3
3 1 13 3 048440 0134 4 8 4 5 6 4 1AIDS HIV 3CD4 4 CD4 HIV 5 6 1 1 k c CD4 3 h HIV k j 4 j 5 t j 6 v j 7 t k j 8 c 9 ' c 10 n 11 N 1 s j j t j CD4 CD4 4
5 1 CD4 HIV CD4 CD4 3 CD4 4 1 1 zdovudnelamvudne ndnavr CD4 HIV 1 CD4 HIV k j c k j = h c h j CD4 HIV j j 5 j j k j
v j k j v j k = t j+ 1 j+ 1 k t j t j v j CD4 vl HIV CD4 00-499/vl CD4 00/vl AIDS 1 CD4 0. /vl CD4 0. 1 1 1 CD4 0~40 40~100 100~ EXCEL CD4 336 m r CD4 HIV 0484 40 048440 CD4 HIV 3 j j j v j 6
[] k mt t kj t = j = 1 = 1,, 3 mt t k j t j = 01,,3, 4 t = 1,,3 t j [] EXCEL 3 ( t = 1,,3) Matlab 4 [] 3 m t 3 0 4 8 4 40 33.7679 77.15918 96.89483 119.863 16.7081 14.1860 40.76365 55.048 76.4377 85.50784 1.8406 18.5493 8.63948 41.67688 5.3539 [3] t 3 5 ( s, ) ( x, y )( = 1,,3; j = 0,1,,3,4) x 048440 j j θ y ( x j, θ ) y ( x j, θ ) y ( x j, θ ) xj ( j = 0,1,,3,4 ) y ( x, θ ) mn 5 j= 1 ( y ( x j n j, θ ) y ) = ( y ( x j, θˆ) y ) = 1 [4] 10 k j 100 80 60 10 0 30 40 7
c x+ b y 1 = ae abc MATLAB [5] abc aˆ =138.7 b ˆ =. 78 cˆ = 3. 94 MATLABnhe.m +. 78 y = 138.7 e 1 3.94 x 5 (y ŷ ) = 1 R = 1 =0.9998 5 (y y) 1 3 140 = 1 10 100 C I 80 60 40 0 0 0 10 0 30 40 50 60 70 80 90 3 zdovudne, lamvudne,ndnavr 3 138.7 8
80 70 60 50 40 30 10 0 30 40 EXCEL y = -0.0614 x + 4.07 x + 1.911 5 0.957 90 80 70 K 60 50 40 30 0 10 0 0 10 0 30 40 50 60 70 5 CD4 00 500 /vl ( 500) 3 CD4 y = 0.16 x + 4.0184 = 0 x=3.8 ' y ' 3.8 k=86.545 1.98466/ 9
50 40 30 10 0 30 40 EXCEL y = -0.0185 x + 1.7097 x + 13 3 7 0.9867 50 40 K 30 0 10 0 0 10 0 30 40 50 60 70 80 90 100 7 ' y = 0.037 x 1.7097 ' y 3 3 + = 0 x=46.081 46.081 CI 5.33816 0.85136/ 10
4 * 3.8 46.081 * 1 CD4 4 Log(CD4 +1) 4 CD4 EXCEL 1 3 4 CD4 EXCEL 4 CD4 CD4 c c = c c ' CD4 c c c c > 0 ' c < 0 EXCEL 5 5 1 3 4 88 14 13 331 197 168 174 8 85 9 97 613 11
n N p n =, = 1,,3,4 N 5 MATHEMATICA 6 6 1 3 4 p 0.31 0.4 0.41 0.54 p 4 =0.54 4 3 CD4 100 CD4 40~100 CD4 0~40 CD4 Log(CD4+1) 0~6.971 CD4 Log413.7136Log 1014.6151 7 7 Log(CD4+1) 0~3.7136 3.7136~4.6151 4.6151~ DPS CD4 7 EXCEL CD4 336 8 8 m r CD4 1
40 40 CD4 5 CD4 CD4 CD4 [] 8 CD4 CD4 c nt t cj t = j = 1 = 1,, 3 nt t c j t j = 01,,3, 4 t = 1,,3 t j CD4 [] EXCEL 5 ( t = 1,,3) Matlab 6 [] CD4 9 CD4 9 CD4 0 8 16 4 3 40 n t 13
50 40 30 0 10 5 10 15 0 5 30 EXCEL 3 y1 = 0.0117x + 0.4413x 1.9773x + 4.7859 9 0.96 9 MATLAB y ' = 1 0 x=.659 4.659 50 00 150 100 5 10 15 0 5 30 14
EXCEL 3 y = 0.053x 3.719x + 49.848x + 66.074 ( 11), 0.94 MATLAB y ' = 0 x=10.094 4 10.094 Mathematca 90 80 70 60 10 0 30 40 EXCEL y 3 = - 0.008x 3-0.305x + 0.5167x - 0.891x + 58.117 + 1.31x - 87.97 0 < x < 5 x 5 13 1 x=16.6 15
MATLAB ' y 3 = 0 x=15.7154 4 15.7154 80 75 70 65 60 10 0 30 40 EXCEL 5 4 3 y 4 = 0.00007x - 0.0075x + 0.77x - 4.304x + 4.101x + 51.37 1 16
MATLAB y ' = 4 0 x=4.3657 4 4.3657 350 300 50 00 150 100 10 0 30 40 EXCEL 4 3 y = 0.0063x - 0.505x + 11.811x - 64.683x 18.016 5 + 0.991 MATLAB ' y 5 = 0 x=3.6 4 3.6 40 35 30 5 10 0 30 40 17
EXCEL 3 y = 0.001x - 0.1556x + 3.19x 18.819 6 + 19 0.955 MATLAB ' y 6 = 0 x=15.603 4 15.603 [6] n = n1 = n = n3 = n4 n p =, = 1,,3,4 N 18
N 1 p1= N p = N3 p3 = N4 p4 p N s N s N, = 1,,3,4 mn (s N ) 1 4 N N N = 1 1000 6 p = 0.31 p = 0.4 p = 0.41 p = 0.54 1 1 p1= N p = N3 p3 = N4 p4 3 N N = 738, N3 = 756, N 4 = 574 1 t=8 4 600mg zdovudne 400mg ddanosne 600 mg zdovudne.5 mg zalctabne600 mg zdovudne 400 mg ddanosne600 mg zdovudne 400 mg ddanosne 400 mg nevrapne 600mg zdovudne 1.60 400mg ddanosne 0.85.5 mg zalctabne 1.85 400 mg nevrapne 1.0 1 81.60+80.85=70.3(); 561.60+1.85)=193.(); 3 561.60+0.85)=137.(); 4 561.60+0.85+1.)=04.4(). t=8 11 1 3 4 s 70.3 193. 137. 04.4 N ( = 1,,3,4) s N 1 1 N 4 8 1 3 4 N 1000 738 756 574 ( N s ) 70300 14580 10370 117330 1 1 3 4 1 19
1 N 1 t 1 1 1 1 08164340 08164 340 CD4 EXCEL 3 x x x MATLAB x1=18.33-6 4 5 3 y = -10 x + 9 10 x - 0.0016x + 0.0041x + 4.038 MATLAB 3.45 0
6 6 3 y = - 10 x + 0.000x 0.0035x + 0.05x + 3.939 MATLAB 33.58 y = 0.0001x 0.013x +.799 1
y = 0.000x 0.016x +.790 6 1 1 300 CD4 HIV 048440 048440 CD4 HIV 1300 08164 340 08164340 CD4 CD4 HIV HIV
HIV CD4 HIV 3 40 40 4 5,,,. DPS CD4 7 1 EXCEL ; 1 HIV 3
[1] []EXCEL [3] [4] [5] [6] 4
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