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1 CHINA MEDICAL SYSTEM HOLDINGS LIMITED * (a) (b) (c) (d) (e) 322(1 (f) (g) (h) (i) (j) (k) (l) *
2
3 Frost & Sullivan 18% ,000 97%86%91.5% 34.6%100,000 CNS 35,000 40, %79.6%75.5%70.2% 90.9%95.1% 96.2%94.0%Frost & Sullivan 28.8% 47.6%
4 100% Dr. Falk Pharma GmbH Frost & Sullivan * *
5 Frost & Sullivan21.9%5% 20.7% 1,107 Frost & Sullivan 38% Frost & Sullivan %Frost & Sullivan 46Frost & Sullivan UDCA 98.0%55.9% (AMD)
6 rhbnp (AAD) 11.9%16.3%21.9%22.9% 35.3%25.4%38.0%32.4% 3006,
7 % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,200 CMSH % 30.8% % 25.6%64.9%61.7%63.1%60.8% % 45.2%16.8%20.7% 21.6% 25.1%
8
9 84.1% 85.2%82.3%76.2% %50.6%46.1%42.5%
10 %5.4%5.0% 3.3% (i)(ii)(iii)
11 CMS024CMS024
12 1
13 ... 51,747 72,600 96,454 46,775 61, (18,149) (27,835) (35,596) (17,139) (23,970)... 33,598 44,765 60,858 29,636 37, ,280 2, (13,934) (18,631) (24,840) (11,366) (13,318)... (2,773) (1,221)... (5,947) (6,940) (7,399) (3,908) (3,274)... (1,633) (2,275) (2,038) (1,057)... (301) (226) (390) (191) (336) (26) ,346 19,535 26,926 13,800 19, (1,672) (4,487) (6,096) (3,243) (4,355)... 8,674 15,048 20,830 10,557 15, ,639 2, (1) (5)... (145) ,313 17,964 20,754 10,576 15, ,685 14,946 20,684 10,448 15, (11) ,674 15,048 20,830 10,557 15, ,335 17,877 20,608 10,467 15, (22) ,313 17,964 20,754 10,576 15,858
14 ... 10,677 5,945 11,060 17, ,305 27,684 32,794 41, ,060 17,641 17, ,601 20,100 15,113 10,340 47,767 55,004 77,120 88, ,920 9,252 11,062 12, ,517 16, ,226 1,848 13,100 10,755 29,788 31, ,667 44,249 47,332 56,937 (1)
15 25%50% Healthlink Healthlink Healthlink
16 [] Business Insights 22 CMS024 CMS024 CMS CMS CMS
17 CMS CMS CMSERP 32 Treasure Sea Healthlink Healthlink Healthlink 99%
18 Viewell LimitedGreat Creation Holdings Limited Archiever Development Limited Wide Harvest Limited Frost & Sullivan Frost & Sullivan (PTC)
19 55% 45% Healthlink Healthlink Consultancy Inc. Healthlink Healthlink87.4% Healthlink IMS Health
20 Healthlink Healthlink 87.4% The London Stock Exchange plc []
21 51% A. 3.
22 % Treasure Sea Treasure Sea Limited
23 %
24 ADHF 9
25 CNS
26
27 GI
28 GAG 1 HBV B
29 Kaplan-Meier LundbeckTakeda
30
31 rhbnp
32 Henri Boulard (AMD) 60 T- T a-
33 BEL-7402 UDCA
34 90.9% 95.1% 96.2% 94.0%Lundbeck Export A/SDr. Falk Pharma GmbH 79.0%79.8%77.4%73.0% Synda LimitedSynda Limited24.5% Ophol Limited
35 84.1%85.2%82.3%76.2% %5.4%5.0%3.3%
36 %79.6%75.5%70.2%
37
38 B %54.2%50.2%45.9%
39 % 24.4%22.9%27.9% CMS024CMS024 HealthlinkCMS024 CMS024Healthlink CMS024 IIbCMS CMS024
40 CMS024 CMS024 CMS024CMS024 CMS024
41 2%10%
42
43 %
44
45
46 8,5001,240 90% ,50061%
47
48 5% 25%
49 2%1.2% 18.1% 11.5%
50
51 2A-2B 5B II C 3 137C Birney Avenue Vancouver BC V6S 0A4 Canada 33 49B 146 Maylands Drive Sidcup Kent DA14 4RL United Kingdom 17 29A
52 A Maples and Calder
53 Maples Corporate Services Limited PO Box 309 Ugland House Grand Cayman, KY Cayman Islands 11 A H 21H2 2A-2B 5B
54 C
55
56
57 I IIIIIIV IV [2007]42
58 [2009]
59 46 (i) (ii)(iii)
60 I(i)(ii) (iii)ii(i) (ii)(iii) I II
61 5 3
62
63 (2009) 25%
64 10%50% 30%3%
65 33% 25% 33% % 15%24%33% 25% 5 515% 18%20%22% 24%25%24% 25% [2009] 25%
66 % 10 15% [2007]215% 95 50%150% 5% 7%5% 1% 10% 5%
67 25% 5%25% 10% ) [2009] %
68
69
70
71 Frost & Sullivan 184,94027, ,35049, %8.7% 14,1442,08525,1253, % 10,493 1,54717,1752, %3, , %
72 % % ,947 22, %6, , %
73 %... 6, , , , , , , , , , , , , , , , % 16.3%
74 90% 8.394% 464.4% 8,5001,
75 653 Frost & Sullivan %1, %
76 Frost & Sullivan %1, % Frost & Sullivan
77 Business InsightsIMS Health 12.2%10.6%2,383 4,7451,149 2,645 Business InsightsIMS Health Frost & Sullivan % 78.8% %
78 Frost & Sullivan Frost & Sullivan 8311, % 16.0%15.4% Frost & SullivanIMS Health 5%21.9% Frost & Sullivan 20.3%
79 8,5001,2508,500 1, % 46.6% Frost & Sullivan
80 Frost & Sullivan % Frost & Sullivan %
81 Frost & Sullivan Frost & Sullivan NT PharmaEdding PharmNovamedHonghui 18% NT Pharma NT PharmaEdding Pharm Novamed Honghui
82 CMS... 22% 22% 18% NT Pharma*... 7% 8% 17% Edding Pharm... 8% 12% 10% Novamed... 2% 7% 10% Honghui... 6% 9% 7% Frost & Sullivan * 80%
83
84 FROST & SULLIVAN Frost & Sullivan Frost & Sullivan Frost & Sullivan60,000Frost & SullivanFrost & Sullivan351,800 Frost & Sullivan Frost & Sullivan
85 30 Frost & Sullivan
86 99% Lundbeck Export A/S Dr. Falk Pharma GmbH Lundbeck Export A/SDr. Falk Pharma GmbH 46.1% 95%2,880,000 90% 3,200,00090%10% 90% 500,00010% 45,0005% 85% 5%
87 75% 10% 5% 5% 5% 83,570, ,000, ,000,000350,000,000 3,000,000 10,000, ,0005% 9,000,000 90% 10% 83% 1,000,00090% 9,000,000 10% 1,000,000 10%
88 10% 1,000,00010% 2,480,000 8,280,000 24% 15,000,000 75% 42,150,000 20,000,000 25%19,980,000 50,000 50, CMS International CMS International10,000 10,0001CMS International CMS11 1CMSCMS International 60%
89 15,407,828 40% Archiever Development Limited 263, ,000,000 55% 7,000,00049% 31%20% 80%20% 55% 45%
90 ,00010,000 1Winpro Development LimitedWinpro73.5% Synda Limited Pharma Stulln GmbH CMS Winpro Winpro 73.5%WinproCMS 22,500, Winprod 18,000,0004,500,000 CMS 15,000, ,000,0003,000,000CMS 49.0% CMSWinpro73.5% CMS 73.5%CMS 24.5%36.7%Synda Limited38.8%
91 10 Pharma Stulln GmbH 10Synda Limited 51% 5,865,000 51% 51% 4,905,000960,000 5,635,000 49% 49% 60,000,000 (i)(ii) (iii)
92 49% 1,329,000 CMSHealthlink HealthlinkHealthlink [] 1387,246, , Archiever Development Limited263, % [][] []
93 Healthlink Healthlink Healthlink HealthlinkHealthlink %Healthlink HealthlinkHealthlink HealthlinkHealthlink 95% 3,000,000 Healthlink17.9% Healthlink HealthlinkHealthlink 5 (i)
94 (ii) 200
95
96 1. (a) 54,195,8205.7% (b) 4,930,0000.5% (c) 43,706, % (d) 5,276,6600.6% (e) 12CMS 2,000,0000.2% %38.8% 4.
97 Frost & Sullivan 18% ,000 97%86%91.5% 34.6%100,000 CNS 35,000 40, %79.6%75.5%70.2% 90.9%95.1% 96.2%94.0%Frost & Sullivan 28.8%47.6% 100%Dr. Falk Pharma GmbH
98 Frost & Sullivan * Frost & Sullivan21.9%5% 20.7% 1,107 Frost & Sullivan 38% Frost & Sullivan *
99 53.1%Frost & Sullivan 46Frost & Sullivan UDCA 98.0%55.9% (AMD) rhbnp (AAD) 11.9%16.3%21.9%22.9%
100 35.3% 25.4% 38.0% 32.4% 3006, % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
101 1,200 CMSH % 30.8% % 25.6%64.9%61.7%63.1%60.8% % 45.2%16.8%20.7%21.6% 25.1% 84.1% 85.2%82.3%76.2%
102 %50.6%46.1%42.5% %5.4%5.0%3.3%
103 Frost & Sullivan %86% , %34.6% 100,000CNS FrostSullivan 34.7% 20.9%
104 Frost & Sullivan %Frost & Sullivan 46Frost & Sullivan 36.5%55.0% 30.8%45.2% 28.8%47.6% 100%Dr. Falk Pharma GmbH
105 % 36.5%55.0%16.8%21.6% 30.8% 45.2%,25.1%
106 21.1%34.4% 28.8%47.6% % CMSERP CMSERP CMSERP CMSERP CMSERP CMSERP
107 CMS024 1,000
108 [] CMSERPCMSERP CMSERP
109 % % % % %.. 47, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
110 Frost & Sullivan CNS ,000 97%86% 40,00035,000
111 *
112 (i)(ii)(iii)
113 70% 4, %86%
114 % % % % ,113 3, ,076 4, ,525 5, ,525 5, , , ,192 1, ,192 1, ,151 1, ,608 2, ,780 2, ,780 2, ,917 1, ,286 1, ,553 1, ,553 2,
115 3,7795,092 5,96891% 34% 70% 15580% 550%10
116 CNS 28.8%47.6% % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , ,
117 (1) H. Lundbeck A/S Dr. Falk Pharma GmbH Pharma Stulln GmbH (2) Bioniche Teoranta Dr. Falk Pharma GmbH Laboratoires Biocodex (1) (2)
118 % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , %10% 30% Frost & Sullivan % Frost & Sullivan 11% % % % % % % % % % % % % % % 3 9.8% % 5 5.2% 5 6.5% 3 7.4% 4 7.5% % 4 6.9% 4 8.0% 4 7.1% 5 7.3% Frost & Sullivan
119 H. Lundbeck A/S 294, % % Frost & Sullivan(UDCA)98.0% UDCA Frost & Sullivan %Frost & Sullivan 50% % % % % % % % % % % % 3 9.6% % % % % 4 2.0% 4 2.2% 4 2.3% 4 1.2% Frost & Sullivan Dr. Falk Pharma Dr. Falk Pharma 302, % %
120 (AMD) Frost & SullivanAMD % AMD7.0%8.3%9.7% 46% 2001, , ,680,000 Frost & Sullivan (HBV)5460 Frost Sullivan360, ,000450,000 5
121 % % %0.7% 1.0% ,184[] % % 5.7 (GAG) ICPBS
122 100,00060 Bioniche Teoranta5 Bioniche Teoranta 5501,0004,000 IMS Health 204 Datamonitor 20% ,271.4% % 1.7 (AAD) Rev Infect Dis % 9.3%PubMed
123 5 (BSI) 1.6%3.1% CMS024 Budenofalk (Budesonide) BudenofalkDr. Falk Pharma GmbH Budenofalk Budenofalk Budenofalk Dr. Falk Pharma GmbH
124 Dr. Falk Pharma GmbH Budenofalk Dr. Falk Pharma GmbH CMS024( ) CMS024 CMS024 CMS024IIIaIIb CMS024IIbCMS024 Kaplan-Meier IIbCMS024 CMS024IIb CMS024 CMS024 CMS024 HealthlinkCMS024 Healthlink Healthlink CMS024 CMS024 CMS024 CMS CMS024 CMS024 CMS02413% CMS024
125 16 2%10% (i)60120(ii) 4560(iii)15
126 Dr. Falk Pharma GmbH Dr. Falk Pharma GmbH 96.8%93.7%90.1%88.9% 67.9%43.2%47.5%41.5% 5% 2448
127 %1.3%1.0%0.8% ,000223,000304,000125,000
128 CMSERP CMSERP
129 %20.6% 21.1%22.3% 5.6%6.6%6.2%6.0% 5%The China Fund, Inc. The China Fund, Inc. 5% 5%
130 9.1%4.1%2.7%1.3% (i) (ii) 95% HealthlinkHealthlink Healthlink Healthlink % % % % 4, , , , , , , ,955.9
131
132 T Sunpharma GmbH Sunpharma GmbHSunpharma GmbH
133 25,000Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Healthlink HealthlinkHealthlinkHealthlink17.9% HealthlinkHealthlink Healthlink Healthlink HealthlinkCMS024 CMS024
134 3.1CMS024 13%CMS024 CMS024 IIIaIIbCMS024 IIb CMS024IIb CMS024 IIb CMS CMS024 CMS024 CMS024 CMS024 CMS024 CMS024CMS024 CMS CMS024 CMS024CMS024 13%3.113% CMS024 CMS024Healthlink CMS024 CMS024 CMS024 CMS024 CMS024
135 CMS024 CMS024 CMS024 Healthlink Healthlink Frost & Sullivan Frost & Sullivan Frost & Sullivan UDCA98.0% 55.9%
136 1, ,265 70% 70% 459,0002,700 50,000
137 55% 30,000 50, CMSERP
138 CMS024CMS024 CMS024IIIaIIb IIbCMS024 CMS CMS024 CMS024 CMS CMSERP CMSERP B. 35, ,
139 19,300, ,422.4 CMS [] 2,451.1
140 (i) (ii) (iii) 37,06045,06037,06026,000 50,000
141 Sunpharma GmbH70% 9,00016,00041,000 44, ,000 Sunpharma GmbH 16,000,000 90,000,000
142 16 90 Sunpharma GmbH70%Sunpharma GmbH70%Pepharm R&D LimitedPepharm R&D Limited 70% 99%Sunpharma GmbH30%Synda LimitedSynda LimitedSunpharma GmbH 25,000Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH81,712.15, , , , Sunpharma GmbH Sunpharma GmbHSunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH107,000157,000
143 9,00016,00041,00044,000 Sunpharma GmbH Sunpharma Sunpharma GmbH Sunpharma GmbH(i) (ii)sunpharma GmbH(iii)(iv) Sunpharma GmbHSunpharma GmbH Sunpharma GmbH Sunpharma GmbH 90%Sunpharma GmbH Sunpharma GmbH18, , Sunpharma GmbH Sunpharma GmbH Treasure SeaHealthlink87.4% Healthlink Healthlink Healthlink HealthlinkCMS024 CMS024Healthlink (1) CMS024
144 (2)CMS024 Healthlink Healthlink Healthlink Healthlink Healthlink HealthlinkHealthlink Healthlink Healthlink Healthlink Treasure Sea 10%
145 (i) 30%(ii)[] Treasure Sea Treasure Sea Treasure Sea 90.9%95.9% 97.2%98.7% 9.1%4.1%2.8%1.3% CMS024
146 Sunpharma GmbH CMS InternationalSunpharma GmbH Sunpharma GmbHCMS international Sunpharma GmbH 107,000157, ,050 Sunpharma GmbHPepharma R&D Limited70% Pepharma R&D Limited70% 99%Sunpharma GmbH 0.1%14A.33(3) CMS024 CMS024 CMS024 CMS024 CMS024 (i) 16 ZL (ii) ZL
147 CMS024CMS024 CMS024 3,100,000 ZL CMS024 13% CMS024 CMS CMS024 CMS CMS CMS024 CMS % CMS024 CMS024 14A HealthlinkHealthlink Treasure SeaHealthlink87.4% 14A.11(4) 14A
148 14A (i)(ii)(iii) (i) (ii)(iii) 0.5%3% , ,
149 13.36(2)(b) 1
150 CMS024 HealthlinkHealthlink HealthlinkCMS024 HealthlinkCMS024 CMS024CMS024 CMS024Healthlink Healthlink HealthlinkHealthlink
151 44 CMS 40 CMS 69 Jebsen & Company 44 CMS Xinglong Enterprise (Shenzhen) Limited
152 47 20 Greater China Corporate Consultancy & Services Sanyo Securities (Asia) Limited Fidelity International Investment Management LimitedKerry Securities LimitedSassoon Securities LimitedCore-Pacific Yamaichi International (HK) Limited 0343 Nouveau Investment Group Limited 47 Northland Bancorp Seymour Pierce Reabourne Technology Investment Management LimitedClose Brothers Asset Management Company University College London Medical School Touche Ross & Co. Bylamson & Associates (Enterprises) Limited Kwan Wong Tan & Wong
153 XV C. (3) 13.51(2) 44 Pfizer 50 CMS024 HealthlinkHealthlinkHealthlink HealthlinkCMS024 CMS024 CMS024CMS024 HealthlinkHealthlink 38 CMS Pharmachentical Agency
154 [] 513, ,000516,000240, , ,000493,000474,000244,000
155 (i) (ii)(iii) (iv)
156 100,000,00020,000,000, ,173, , (i)(ii)(iii) 20% (i) (ii) (iii)
157 0.5% 3% 451,000104, ,52811,
158 ,000,00020,000,000,
159
160
161 1... 6,430 8, ,652 24, , ,786 23, ,006 5, ,287 4, ,195 6, ,594 3, ,239 32, ,233 9, ,226 8, ,085 1, ,079 2, ,193 54, ,751 4, ,999 7, ,152 3, ,769 2, ,484 5, ,015 22, ,056 10, ,539 26, ,604 19, ,053 11, ,308 90, ,668 66, ,940 43, ,419 45, ,975 29, ,450 25, ,630 53, ,999 34, ,254 32, ,367 2, ,792 62, ,645 63, , ,
162 Frost & Sullivan 18% ,000 97%86%91.5%34.6% 100,000 CNS 35,000 40,000
163 79.0%79.6%75.5%70.2% 90.9%95.1% 96.2%94.0%Frost & Sullivan 28.8%47.6% 100%CMS024 Dr. Falk Pharma GmbH Frost & Sullivan
164 * Frost & Sullivan21.9%5% 20.7% 1,107 Frost & Sullivan 38% Frost & Sullivan %Frost & Sullivan 46Frost & Sullivan UDCA 98.0%55.9% *
165 (AMD) rhbnp (AAD) 11.9%16.3%21.9%22.9% 35.3%25.4%38.0%32.4% 3006, % 30.8% % 25.6%64.9%61.7%63.1%60.8% % 45.2%16.8% 20.7%21.6%25.1% (i)
166 (ii) Healthlink Healthlink Healthlink 82.1%Healthlink17.9% Healthlink1,969,0008,487, %Healthlink 38,921,747HealthlinkHealthlink 1
167 % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , %79.6%75.5%70.2%
168 % % 11.9%16.3%21.9%22.9%
169
170 16.2%23.0%22.6%22.1% 25% 25%
171 92, ,00010,000116, %
172 ,00023,00057,00021,
173 ,500,0001,098,000 (Ophol Limited)24.5%6.01,500, , % 5.0%
174 % % % % %... 47, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
175 Synda Limited Synda Limited Synda Limited10 Synda Limited4%6%Synda Limited 36.7%Synda LimitedSunpharma GmbH20% Sunpharma GmbHSynda Limited Synda Limited (i) (ii) 64.9%61.7%63.1%60.8%
176 % % % % % (405) (0.4) (272) (0.6) (109) (0.2) (70) (0.1) (8) 2 7 (2) 6... (805) (0.8) , ,
177 % % % % %... 6, , , , , , , , , , , , , , , , , , , , , , , , , [] [] [][] [] % % % % %... 2, , , , , , , , [] , , , , , , , ,
178 51% % 70, % 49.0%24.5% 55% 45% 55%
179 %, 23.0%, 22.6%22.1% 25%... 15% (1) 18% 20% 20% 22%... 15% (1) 18% 20% 20% 22% (2)... 15% 15% 15% 15% 15%... 25% 25% 25% 15% (3) (1) 15% (2) 15% 15% (3) 15%
180 % % % % % ()... 51, , , , , (18,149) (35.1) (27,835) (38.3) (35,596) (36.9) (17,139) (36.6) (23,970) (39.2)... 33, , , , , , , (13,934) (26.9) (18,631) (25.7) (24,840) (25.8) (11,366) (24.3) (13,318) (21.8) []... (2,773) (5.4) (1,221) (2.0)... (5,947) (11.5) (6,940) (9.6) (7,399) (7.7) (3,908) (8.4) (3,274) (5.4)... (1,633) (3.2) (2,275) (3.1) (2,038) (2.1) (1,057) (2.3)... (301) (0.6) (226) (0.3) (390) (0.4) (191) (0.4) (336) (0.5) (26) (0.1) , , , , , (1,672) (3.2) (4,487) (6.2) (6,096) (6.3) (3,243) (6.9) (4,355) (7.1)... 8, , , , , , , (1) (5)... (145) (0.2) , , , , , , , , , , (11 ) (0.0 ) , , , , , , , , , , (22 ) (0.1 ) , , , , ,
181 % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , % % % %
182 77.3% 70.2%35.4% % % % % % % 24.0% 49.2% %1.3% 39.9% % %60.8%
183 21.0% CMS % (i) 29.4% (ii) 5.7% (iii) 2.5%24.3% 21.8% [] [][] % (i) Healthlink 0.2(ii)0.2 (iii) %8.4% 5.4% Healthlink HealthlinkHealthlink 75.9%
184 42,000 51% 24.5% 26,00045,000 19, % 42,000 25,000 21, % % 22% 25%15% 23.5% 22.1% 45.2% %25.1% 32.9% % % % %
185 680.3% ,271.4% % % %2.8% 27.9% % %63.1%(i) (ii) 75.4% % (i)2.3 (ii) 25.1% (iii) 25.8%25.7%
186 6.6% %9.6%7.7% 10.4% Healthlink % % %0.1 43, % %20% 23.0%22.6% 38.4% %21.6% 40.3% %
187 40.4% % % % % %4.1% 53.4% (i) (ii) 33.2% %61.7% (i)(ii)(a) (b) 110.2% Dr. Falk Pharma GmbH0.8 CMS % (i)23.0% (ii) 41.8% (iii) 1.2%26.9% 25.7%
188 [] [][]2.8 [] 16.7% (i)16.8% (ii)[](iii) 1.9%11.5% 9.6% 39.3% Healthlink % % 171.4% % %18% 5% 16.2%23.0% 73.5% %20.7%
189 ... 6,572 10,175 15,549 9,369 4, (1,861) (1,744) (16,616) (5,800) (2,812)... 3,072 (7,219) (4,022) (5,564) (6,937) 7,783 1,212 (5,089) (1,995) (5,076)... 8,948 17,601 20,100 20,100 15, ,601 20,100 15,113 18,129 10, (a) 6.4 (b)8.3 (c)
190 (a)2.8 (b) (a)5.2 (b) (a)7.5 (b)5.0 (c) (a)9.0 (b) 4.5(c) 7.7
191 % % % % % 0.860%100% (i)4.7(ii)[]1.4(iii) 0.5(iv)0.2(v) 40%
192 , Healthlink , [] ,246, []4.30.3
193 ... 10,677 5,945 11,060 17,437 15, ,305 27,684 32,794 41,485 43, ,060 17,641 17,792 13, ,601 20,100 15,113 10,340 7, ,767 55,004 77,120 88,308 81, ,920 9,252 11,062 12,235 6, ,517 16,346 12, ,226 1, ,100 10,755 29,788 31,371 20, ,667 44,249 47,332 56,937 61, ,486 5,795 10,806 17, ,677 5,945 11,060 17,437 (1) (1)
194 92,000119,00010,000116, (i) (ii) (i) (ii) %
195 ... 14,785 17,441 20,959 29, (307) (221) (213) (235)... 14,478 17,220 20,746 28, ,669 7,062 9,513 8, ,158 3,402 2,535 3, ,305 27,684 32,794 41,485 (1) (1) (i) (ii)
196 %1.3%1.0% 0.8% ,797 2,127 2,274 3, ,184 2,071 2,174 2, ,107 4,291 4,476 5, ,371 12,929 16,270 23, ,478 17,220 20,746 28, %
197 ,272 5,562 6,067 4, , ,401 5,593 6,079 4,307 (1) (1)
198 [] (1)... 16,517 16,346 12, ,179 5,291 4,986 5,020 (1) 12,548,000 13,533,000337, ,667, %15.8%
199 , , ,000 []
200 ,439 6, ,699 2,575 7, ,003 6, ,520 10, ,846 3,699 2,575 30,120 41
201 75.1%70.1%76.4%81.7% 10.4
202 25%-50% Healthlink Healthlink Healthlink 7,457,000
203
204
205 [] [] London Stock Exchange plc [] CMS 10, % 100% 100% 100% 100% CMS1 CMS Peptides Patent Holding % 70% Company Limited 2 CMS Peptides Healthlink Consultancy Inc 474, % 100% Healthlink 2 100% 100% 100% 100% 100% 20,000,000 70% 70% 3,660,
206 100% 100% 100% 100% 100% 10,000, % 100% 100% 100% 100% 21,288, % 100% 1,300, % 100% 100% 100% 100% 150,000, % 100% 10,609, % 100% 100% 100% 100% 10 60% 60% 60% 100% 100% Crosspac Group Limited 10 70% 70% Crosspac % 100% 100% 100% 2,000,000 CMS 1 100% 100% 100% 100% CMS 1. CMS 2. HealthlinkCMS Peptides CrosspacHealthlink (b)
207
208
209 A ,747 72,600 96,454 46,775 61, (18,149) (27,835) (35,596) (17,139) (23,970)... 33,598 44,765 60,858 29,636 37, ,280 2, (13,934) (18,631) (24,840) (11,366) (13,318) []... (2,773) (1,221)... (5,947) (6,940) (7,399) (3,908) (3,274)... (1,633) (2,275) (2,038) (1,057)... 7 (301) (226) (390) (191) (336) (26) ,346 19,535 26,926 13,800 19, (1,672) (4,487) (6,096) (3,243) (4,355) ,674 15,048 20,830 10,557 15, ,639 2, (1) (5)... (145) ,313 17,964 20,754 10,576 15, ,685 14,946 20,684 10,448 15, (11) ,674 15,048 20,830 10,557 15, ,335 17,877 20,608 10,467 15, (22) ,313 17,964 20,754 10,576 15,
210 ,940 5,459 3,575 3, , ,507 1, ,575 6,461 5, ,073 1,432 1,153 7,177 15,490 13,657 15, ,677 5,945 11,060 17, ,305 27,684 32,794 41, ,060 17,641 17, ,601 20,100 15,113 10,340 47,767 55,004 77,120 88, ,920 9,252 11,062 12, ,517 16, ,226 1,848 13,100 10,755 29,788 31, ,667 44,249 47,332 56, ,844 59,739 60,989 72, ,725 4,725 4,741 4, ,275 48,065 48,992 60, ,000 52,790 53,733 64, (156) (69) ,844 52,721 53,934 64, ,764 2, ,179 5,291 4,986 7,018 7,055 7,275 41,844 59,739 60,989 72,229
211 ,363 13,589 18,469 14, ,365 13,623 18,482 14, , ,267 13,436 18,340 14, ,287 13,456 18,350 14, ,725 4,725 4,741 4, ,562 8,731 13,609 9,736 21,287 13,456 18,350 14,504
212 ,909 2, ,080 (46) 13,223 (138) 13, ,650 1,650 (11) 1, ,685 8,685 (11) 8, ,650 8,685 10,335 (22) 10, ,998 (3,998) ,264 19,989 19, (570) (1,547) (1,547) (1,547) (4,725) 4, ,822 (845) (977)... 4,725 17,147 4, ,255 2,730 2,937 4,725 42,000 (156) 41,844
213 ,725 17,147 4, ,255 2,730 2,937 4,725 42,000 (156) 41, ,895 2,895 (15) 2, ,946 14, , ,931 14,946 17, , (2,362) (4,725) (7,087) (7,087)... (4,725) 4, ,802 (1,802)... 4,725 17,147 4, ,057 5,661 8,994 4,725 52,790 (69) 52,721
214 ,725 17,147 4, ,057 5,661 8,994 4,725 52,790 (69) 52, (1) (1) (1)... (145) (145) (145)... 20,684 20, , (145) 20,684 20, , (8)... (36) (206) (206)... (11,503) 853 (10,650) 330 (10,320)... (4,741) (4,725) (9,466) (9,466)... (4,741) 4, ,102 (2,102)... 4,741 6,079 4, ,159 6,555 (145) 18,122 4,741 53, ,
215 ,725 17,147 4, ,057 5,661 8,994 4,725 52,790 (69) 52, ,448 10, , ,448 10, , (4,725) (4,725) (103) (4,828) (4,725) 4, ,339 (1,339) 4,725 17,147 4, ,396 5,680 13,378 4,725 58,532 (63) 58,469
216 ,741 6,079 4, ,159 6,555 (145) 18,122 4,741 53, , (5) (5) (5) ,230 15, , ,230 15, , ,299 2,325 2, (2,221) (2,221) (104) (2,325)... (201) (201)... (4,741) (4,741) (4,741)... 1,068 (1,068)... 4,768 8,481 2, ,227 7,047 (113) 32,284 64,954 64,954
217 ... 10,346 19,535 26,926 13,800 19, (56) (152) (30) 26 (42). (43) (21) (25)... (647) (647) , (236) (221) (329) (94) (302)... (30) (20) []... 2,773 1, (2) (7) 2 (6) (24) ,944 21,080 29,198 14,331 21, (8,986) 5,347 (5,226) (2,840) (6,432)... (4,545) (7,526) (5,287) (2,976) (8,255)... (31) (375)... (56) (8) (481) (25). 624 (23) 43 (18)... 7,734 (5,011) 2,284 3,174 1, (6)... 8,709 13,859 20,672 11,674 7, (2,111) (3,637) (5,008) (2,300) (3,254)... (26) (47) (115) (5) (6)... 6,572 10,175 15,549 9,369 4,673
218 ... (795) (959) (280) (59) (101)... (2,919) (a) (770)... (149) (537)... (1,060) (16,581) (5,069) (151) (b) (1) (877) (877)... (1,861) (1,744) (16,616) (5,800) (2,812)... (7,082) (9,471) (4,730) (4,741)... 39(a) (10,068)... (137) (1,245) (731) (512)... 19, ,757 16,517 2, (4,320) []... (1,416)... (12,905) (2,726)... (5,148)... (301)... (206) (103) (201)... 3,072 (7,219) (4,022) (5,564) (6,937)... 7,783 1,212 (5,089) (1,995) (5,076)... 8,948 17,601 20,100 20,100 15, , ,601 20,100 15,113 18,129 10,340
219 1. London Stock Exchange plc[] [] Limited PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman IslandsA8 CMS []VI ,221, IFRIC* 14 4 IFRIC19 3 * IFRIC 1
220 []
221
222
223
224
225
226
227
228
229
230 [] 4.
231 610,0007,575,0006,461,0005,786, ,0001,073,0001,432,0001,153, ,000581,000379,000379, ,478,00017,220,00020,746,00028,931, ,000221,000213,000235,000
232 ,000622,0001,334,000 3, ,000 2,022,000 8 (1) (2)
233 ... 47,013 4,734 51, ,841 (3,841)... 47,013 8,575 (3,841) 51, ,260 4,338 33, , (13,934) []... (2,773)... (5,947)... (1,633)... (301) , ,595 3,005 72, ,496 (4,496)... 69,595 7,501 (4,496) 72, ,237 2,528 44, , (18,631)... (6,940)... (2,275)... (226) ,535
234 ... 93,752 2,702 96, ,100 (2,100)... 93,752 4,802 (2,100) 96, ,419 2,439 60, (24,840)... (7,399)... (2,038)... (390) , ,188 1,587 46, (484)... 45,188 2,071 (484) 46, ,184 1,452 29, (11,366)... (3,908)... (1,057)... (191)... (26) ,800
235 ... 60, , (430)... 60,389 1,236 (430) 61, , , (13,318) []... (1,221)... (3,274)... (336) ,689 3
236 , , , ,
237 ... 26,144 36,710 44,468 22,768 26, ,756 21,074 28,327 13,393 16, ,011 4,394 6,146 2,817 3, ,599 3,910 4,780 2,243 2, ,839 7,253 2,983 5, , , , ,237 3,474 3,141 1,742 1, ,747 72,600 96,454 46,775 61, (405) (272) (109) (70) (8) 2 7 (2) (805) ,280 2,
238
239
240 Paul Bernard Harper Stuart Hamilton Leckie
241 ,000,
242 ,864 4,236 5,443 2,725 3, ,885 4,305 5,546 2,725 3, (6) (21) (11) (7) (11) (169) (38) (207) ,672 4,487 6,096 3,243 4,355 33% 30%3% 63 15%25%
243 15% 18%20%20%22% 15% 15% 15% 15% Labuan Offshore Business Activity Tax Act 1990Labuan 20,0006,000 3% 17.5%16.5% 17.5%16.5%16.5%16.5%16.5%
244 ... 10,346 19,535 26,926 13,800 19, ,552 3,516 5,385 2,760 4, (9) (4) (6)... (8) (27) (6) 5 (9) (337) (122) (52) (1) (17) (177) (78) (28) (4) (198) (265) (280) (131) (13) Labuan... (133) (629) (260) (627)... (6) (21) (11) (7) (11)... (169) (3) (2)... (38) (2) ,672 4,487 6,096 3,243 4,355 15%18%20%20%22%
245 ,633 10,668 13,082 5,658 5, ) ,675 11,827 14,723 6,199 6, [] )... 2,773 1, , ,413 25,753 34,078 16,349 23, London Stock Exchange plc
246 ,362 4, ,307 4,725 4,725 4, ,418 7,087 9,466 4,725 4, ,307 4,725 4, , ,725 4,725 4,725 4,741 4, ,362,000 4,741,0004,725, ,725,0004,725,0004,741, Healthlink 39(a)... 8, ,969 10,650
247 ,685 14,946 20,684 10,448 15, ,647, ,927, ,290, ,927, ,963, ,965 5,132,705 10,643, ,186, ,927, ,422, ,927, ,607, ,980,000
248 , , , (568)... (18) (16) (17) (51)... 2, ,223 1,228 1,055 8, (108) (32) (140)... 2, ,562 1,836 1,334 9, (32) (409) (24) (465)... (12) (12)... (926) (57) (983)... 2, ,716 1,556 1,287 8, (31) (1) (32)... 2, ,731 1,585 1,343 8,512
249 , (18) (7) (13) (38) , , (97) (29) (126)... 1, , , (30) (305) (17) (352)... (6) (6)... (600) (37) (637) , , , (26) (1) (27)... 1, , , , , , , ,987 1, , , , , , , %
250 4.75% 18% 18% 18% , , , []
251 17. [] % 55% 55% (459) (518) (704) (731)... (26) (42)
252 , (14) (14) [] ,687 1, (52) 157 (180) (189) ,507 1,498 51% 51% % 24.49%
253 (1) 51% 411,235,0001,765,000181,000258,000 70,000 (2) 22,500,0003,295, %18,000,000 2,636,0004,500,000659, %7,500,0001,098, % 38.78%36.73% 7,500,0001,098, %6,000, ,0001,500,000219, %647, , , (65) (161) (1) ,050 6,154 6, ,507 1,498
254 ... 1,084 1,654 2, (9) (3) (23) (26) (1) (5) % 5,865,000770,000 2,550,000335, ,000126,000 1,329,000187,000 51% 20b
255 20. a b a(i) a(ii) ,775 7, (717) 628 (89) ,403 8, ,403 8, a(iii)... (258) (258) ,403 8, (59) (59)... (2) (2)... (61) (61)... (14) (14)... (302) (491) (793) (288) (491) (779)... (294) (821) (1,115)... (582) (1,312) (1,894)... (3) (3)... (49) (370) (419) (634) (1,682) (2,316) ,912 7, ,091 6, ,721 5,786
256 (a) (i) , ,000126, (b) 628,000 (b) (ii) Lyophilized Recombinant Human Brain Natriuretic Peptide Nesiritide Nesiritide NesiritideNesiritide 2,000Nesiritide 2,000Nesiritide 2,000 2,0006,500,000919,000 Nesiritide Nesiritide 919,000 3 (iii) 2,000 1,755,000258,000
257 (b) Pharma Stulln GmbHPharma 1951% 60,000,0008,779,000 CMSPharmaCMS 6,000,000878, ,775,000105%878,000 CMSPharma (202) , ,000
258 10%20%15%15% (839) (17) (203) ,073 (839) (925) 120 (561)... (5) (5)... 1,312 (1,764) 120 (332) 9... (268) (525) (12) (805) ,045 (2,289) 108 (1,136) 14
259 ,073 1,432 1, (839) (1,764) (2,289) (332) (1,136) 4,310,0006,659,0002,178,000 2,294,000 3,804,0005,859,000 1,378,0001,439,000 16,772,000 35,280,00045,766, ,486 5,795 10,806 17,305 10,677 5,945 11,060 17,437
260 ,785 17,441 20,959 26, (307) (221) (213) (235) 14,478 17,220 20,746 28, ,669 7,062 9,513 8, ,158 3,402 2,535 3, ,305 27,684 32,794 41, ,164 14,811 17,879 25, ,188 2,316 2,839 3, ,478 17,220 20,746 28,931 4,107,0004,291,0004,476,000 5,929,000
261 ,797 2,127 2,274 3, ,184 2,071 2,174 2, ,107 4,291 4,476 5, (127) (65) ,000221,000213,000235, (a) Hui Ki Fat
262 (b) 312,000335,000 (a) (b) 26. [] %5.00% 0.36%5.00%0.36%1.71%0.50%2.25% 1,060,000 17,380,000 17,456, ,000336,000
263 ,272 5,562 6,067 4, , ,401 5,593 6,079 4, ,049 1,564 2,239 2, , ,030 1,634 1,818 4,262 12,920 9,252 11,062 12, ,557 5, ,960 10,440 16,517 16, ,517 16, %1.87%1.39%1.87% 0.35% 0.58% 1.62%0.25%0.89%
264 17,380,00017,456, ,179 5,291 4, ,864 6,129 5,797 60,000,000 8,779,00020(b) 6,000,000878,0005%6,775,000 6,864,0005,966,0005,633,000 18(2) (18)
265 (i) 3,765, %1.47% 1,470, %1.68% 1,617, %1.68% 2,108, %1.68% 3,765, %1.47% 1,470, %1.68% 1,617, %1.68% 2,108, %1.68% 1,481, % (ii) 2,140, ,821, ,470, ,620, ,140, ,140, ,821, ,470, ,620, ,140, ,510,
266 ,000 1, ,000 99, ,000, , ,000, ,000, , ,980 3,998 []2... 7, ,246 4, ,408 4, , ,691 4,768 (1) 990,000, ,000,0001,000,000,000 39,980,0003,998,000 (2) 7,246, (3) 162,52811, (4) 263, (5) ,000,000, ,691,
267 ,695 [] ,000 1,151,000575, % 1,151,000[] 708, ,173, % %... 4% ,000
268 34. CMSHealthlink[] CMSHealthlink 32 2,221, % 25%
269 ... 5,707 5, (2,864) (2,864)... (3,998) (3,998) []... 19,264 19, (570) 570 []... (1,547) (1,547)... (4,725) 4, ,147 1, (7,589) 4,725 16, (744) (744)... (2,362) (4,725) (7,087)... (4,725) 4, ,147 1, (15,420) 4,725 8, ,412 25, (11,503) (11,503)... (4,741) (4,725) (9,466)... (4,741) 4, ,079 1, ,741 13, (1,534) (1,534) ,299 2, (4,741) (4,741)... 8,481 1, (1,024) 9,736 CMSHealthlink []CMSHealthlink 32
270 35. Human PharmapepCrosspac70% Human PharmapepCrosspac ,932 45,657 63,494 66, (145) (131)... (12,920) (16,116) (29,771) (28,582)
271 ... 22,365 13,623 18,482 14, (1,098) (182) (142) 8,960,00010,440, %, 70.1%, 76.4%81.7% 31(ii) 31
272 ... 5,026 6, , ,628 4,946 8, , , ,719 1, % 7% 7% 7% (94) [][] 5% 558, ,000
273
274 ,920 12,920 12, ,252 9,252 9, ,512 4,389 8,642 6,864 9,993 3,512 4,389 17,894 16, ,125 7,125 7, ,679 3,032 7,590 6, ,682 7,682 7, ,014 9,014 8,960 24,700 3,679 3,032 31,411 29, (53) (53)
275 ,439 6,439 6, ,699 2,575 7,158 5, ,003 6,003 5, ,520 10,520 10,440 23,846 3,699 2,575 30,120 28, (18) (18) (18)... (35) (35)
276 [] []
277 38. (a) Vincent Hui 60% 3386,000 60%Vincent Hui , (1)... (2,831)... (6)... (257)... (5)... (454) (4) (386) (344)
278 Hui Ki Fat40% 263, (b) 100% ,000 39(b) (19) (4) (198)... 5 (193)
279 39. (a) Healthlink0.1Healthlink Healthlink Group 17.9%82.1Healthlink HealthlinkHealthlink17.9 Healthlink1,969,000Healthlink82.1% Healthlink 8,681,000Healthlink Group38,921, Healthlink1,969,000 Healthlink , (185) 8, , , , ,969 10,068 Healthlink 1,948,000 2,299,0001,138,000955,000 8,000
280 622,0001,344,0003, ,0002,022, ,000275,0001,645, ,000394,000197,000 (b) (341) (226) (24) ,000 15,000 44,00095,00075,000 43, ,
281 41. (a) 25 * Sunpharma GmbH # Hui Ki Fat 2,325 * [] # Sunpharma GmbH
282 (b) Ai... 3,000 4,537 11,606 11, ,463 4,394 4,400 3,000 6,000 16,000 16, ,062 3,450 5,277 2, ,062 3,450 5,277 2,437 Bii... 10,252 10, ,929 2,945 13,181 13, ,648 4, ,648 4,267 (i) (ii) (c) 8
283 ,000638, ,000314, (PTC) (a) (b) (c) (d) 5 (d) 0.5%3% 451,000104, ,52811,83532
284 B. [] Limited C. 499,000 D. E.
285 1. 2. (1) (2) (3) (4)
286
287 2
288 []512 (HK$) () MRICS MHKIS MSC(e-com) MRICS MHKIS MSC(e-com)24 17
289 1. 100% 15,100,000 15,100, ,260,000 17,260, % 1,300,000 1,300,000 14B1 1,490,000 1,490,000 16,400,000 16,400,000 18,750,000 18,750, % 19,400,000 19,400,000 G ,180,000 22,180,000
290 4. 100% % 11 A68
291 6. 100% 1063 A % % 35,800,000 35,800,000 40,930,000 40,930,000
292 1. 15,100, , , ,260, % 7 15,100,000 17,260, (2009)35035, , , , ,
293 , UDCA... 1, , (a) (b)
294 ,300, B ,490, % 50 1,300,000 1,490, (a) (b)
295 3. G , ,400,000 22,180, % 19,400,000 22,180, (2009) 5063) 36, ,300,500 (a) 40% (b) 2.2 (c) (d) 30% (e) 229 (f) , PS ,130 76,6303,
296 4. 5. (a) (b) (c)
297 CMS ,964 1,351 68, IsIand Communication Investments Limited CMS 4. (3)
298 , ,046 A (a) (b) (c)
299 , A3 65, (a) (b) (c)
300 , C % 4. (a) (b) (c)
301 8. 1, , ,
302 7. (a) (b) (c)
303 [] 2. [] A. 100,000,000 20,000,000, B. (a)
304 (b) (c) (d) (e) (f) (i)
(1)... (2) (3)... (4)... elpo (5) (www.cms.net.cn) (www.hkex.com.hk)... (6)...
CHINA MEDICAL SYSTEM HOLDINGS LIMITED * 200,000,000170,000,000 30,000,000 20,000,000 180,000,000150,000,000 30,000,000 5.06 1% 0.004%0.005% 0.005 867 32 342C 5.063.60 5.06 1% 0.004%0.005% 3.60 5.06 www.hkex.com.hk
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