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- 玫 伍
- 5 years ago
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1 Hansoh Pharmaceutical Group Company Limited (a) (b) (c) (d) (e) (f) (g) (h) (i) (j) 1933 (k)
2 [Logo] Hansoh Pharmaceutical Group Company Limited [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] C [ ] [ ] [ ] [ ] [ ][ ] [ ][ ] [ ][ ][ ] [ ] [ ] [ ][ ] [ ] [ ][ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] ( [ ] ( )[ ][ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] (i) 144A (ii) S [ ] [ ]
3 [ ] ii
4 [ ] iii
5 [ ] iv
6 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ][ ] [ ] [ ] [ ] [ ] [ ] ii v [ ] [ ] v
7 [ ] [ ] [ ] [ ] [I-1]... [II-1]... [III-1]... [IV-1]... [V-1] vi
8 [ ] [ ] [ ] (i) (ii) (iii) (iv) % %83.4%85.7% 89.8% % 13.9% % % 8.1% % %92.7% 92.6% 93.4% 28.7%27.2%25.8% 27.6% 1
9 FDA 2
10 Frost & Sullivan % Frost & Sullivan % Frost & Sullivan % Frost & Sullivan
11 CMC
12 4,200 1,900 5,
13 % % % % %... 5,045, ,432, ,185, ,974, ,774, (374,573) (7.4) (397,279) (7.3) (455,171) (7.4) (213,473) (7.2) (250,192) (6.6)... 4,670, ,035, ,730, ,761, ,524, , , , , , (2,240,230) (44.4) (2,378,040) (43.8) (2,704,200) (43.7) (1,308,407) (44.0) (1,558,557) (41.3)... (454,719) (9.0) (537,972) (9.9) (614,075) (9.9) (284,056) (9.5) (368,292) (9.8)... (408,980) (8.1) (403,065) (7.4) (575,544) (9.3) (256,126) (8.6) (362,609) (9.6)... 42, , , , (6) (0.0) (3,411) (0.1)... 1,690, ,804, ,932, , ,278, (241,642) (4.8) (328,244) (6.0) (337,318) (5.5) (169,146) (5.7) (235,724) (6.2)... 1,448, ,476, ,595, , ,042, ,185,194 3,463,699 4,417,867 5,700, ,307,911 1,811,964 1,227,674 1,497, (1,122,717) 1,651,735 3,190,193 4,203, ,245,285 1,357,252 1,456,181 1,542, , , , (1) (%) (2) (%) (3)
14 (1) (2) 100% (3) [ ] Stellar Infinity [ ] [ ] Stellar Infinity Sunrise Investment Sunrise Investment Sunrise Sunrise Sunrise Stellar Infinity Sunrise Investment [ ] [ ] [ ] [ ] [ ] D.[ ] 7
15 [ ] [ ] [ ] [ ] [ ] [ ][ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 8
16 [ ][ ][ ] [ ] [ ] (i) [ ] [ ] (ii) [ ] [ ] [ ] [ ] [ ] [ ] [ ] (i) [ ] (ii) [ ] (iii) [ ] (iv) [ ] [ ] [ ] [ ] [ ]
17 [ ] [ ] (i) (ii) (iii) [ ] [ ] 10
18 [ ] Apex Medical Apex Medical Company Ltd [ ] [ ] [ ] [ ] 11
19 [ ] Stellar InfinitySunrise Investment Fortune Peak Fortune Peak Company Ltd
20 Frost & Sullivan Frost & Sullivan [ ] Frost & Sullivan [ ] [ ] Hillhouse SuperX Holdings Limited [ ] 3% [ ] [ ] 13
21 [ ] [ ] [ ] 14
22 [ ] [ ] [ ] 15
23 [ ] [ ] [ ] [ ] 16
24 [ ] [ ] [ ] 300 [ ] [ ] 144A S S [ ] 144A 144A 17
25 [ ] Stellar Infinity Stellar Infinity Company Ltd Sunrise Investment 100% Sunrise Investment Sunrise Investment Advisors Limited Sunrise 100% 18
26 Sunrise Sunrise Sunrise Sunrise Sunrise Harmonia Holding Investing (PTC) Limited [ ] 1933 [ ] 19
27 API Xa Bcr-Abl 9 ABL 22 BCR (CML) (ALL) (AML) 20
28 II 1.1 CDA cgmp 21
29 EDQM EGFR 22
30 Bcr-Abl TK GMP HS HS EGFR 23
31 KFDA (Korea Food and Drug Administration) 24
32 D2/5-HT2 PMDA GLP-1 II 5-HT4 25
33 Xa TKITK FDA -IV(DPP-IV) II 26
34 27
35 28
36 [ ] [ ] %83.4%85.7% 89.8% 29
37 30
38
39 (2015)) (2015)) (2015)) 32
40 (2017))
41 %7.4%9.3% 9.6% 34
42
43 [ ] [ ] (1)
44 (2) 10 37
45 14 38
46 39
47
48 %83.4%85.7% 89.8% %56.0%58.0% 57.0% %26.0%25.8% 24.3% 41
49 FDA PMDA 42
50 43
51 44
52 45
53 46
54 , , , ,
55
56 18 49
57 50
58 51
59 52
60 53
61
62 55
63 15% 25% % 25% 56
64 57
65 ,
66 59
67 [ ] [ ]
68 61
69 2008 GDP % %, % % 62
70 63
71 (2015)) %
72 % 10% 10% 10% 20% 65
73 (i) (ii) < >
74 (i) 30% (ii) 30%
75 % % 3.0% % 2%
76 [ ][ ] 2008 [ ] [ ] [ ] [ ] 69
77 (i) 10% 50% (ii) 70
78 10% [ ] [ ] [ ] [ ] [ ][ ] [ ] 71
79 [ ] [ ] [ ] [ ] 72
80 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 73
81 [ ] [ ] [ ] [ ] [ ] [ ] [ ] 74
82 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 75
83 [ ] [ ] 76
84 [ ] 8.12 [] 8.12 (a) 3.05 (b) (c) (d) [ ] (e) (f) 77
85 [ ] (i) (ii) 159 (iii) 50 (i) [ ] (ii) (iii) (iv)
86 [ ] [ ] 8.08(1)(d) [ ] 8.08(1)(a) 8.08(1)(a) 25% 8.08(1)(d) % 25% [ ] [ ] [ ] [ ] [ ] [ ] (i) 15% (ii) [ ] [ ] [ ] 79
87 (iii) [ ] [ ] [ ] (i)(ii) (iii) 8.08(1) 25% (i) [ ] [ ] [ ] (ii) [ ] (iii) [ ] (iv) [ ] [ ] 80
88 [ ] [ ] 81
89 [ ] [ ] 82
90 [ ] [ ] 83
91 [ ] [ ] 84
92 [ ] C B B
93 [ ] B [ ] [ ] [ ]
94 [ ] [ ] B B [ ] 87
95 P.O. Box 309 Ugland House Grand Cayman KY Cayman Islands B
96 [ ]
97 [ ]Frost & Sullivan [ ] Frost Sullivan 1 [ ][ ] [ ][ ] [ ] [ ][ ][ ] [ ] [ ] , , % 1 Frost & Sullivan Frost & Sullivan 1961 Frost Sullivan Frost Sullivan 1,072,720 Frost Sullivan Frost & Sullivan [ ] [ ] Frost & Sullivan (i) (ii) (iii) (iv) (v) Frost Sullivan Frost Sullivan Frost Sullivan 90
98 % , , , % , % , ,376 4, % 15 GMP 91
99
100 % % 9.8% % 13.5% % 4.0% % 13.8% % 8.0% % 8.9% % 8.0% 93
101 2017 1, % % % % 2.1%0.8% 45.4% %
102 2017 1, % % ,000 4,000 3,000 2, , , , , , , , , , , % % % (TKI) 95
103
104 2017 (NRDL) %
105 AML , % % , % % 98
106 I II II 98% % % % % 2017 DPP-4 GLP-1 SGLT % % 99
107 II , , (i) (ii) (iii) (PPIs)
108 2013 1, , % % , % 15.6% % 75.6% % 70% 101
109
110
111
112
113 5 6 GMP GMP GMP 6 GMP GMP 106
114 I II III IV 107
115
116 [2017] < > [2016]41 109
117 [2017] [2015]44 [2016]
118 < >
119
120
121 2 GSP GSP GSP GSP GSP
122 [2017] [1999]
123
124
125 < > < > [2009] < > [2009]59 118
126 [2016] [2016]
127
128
129 % 11% 6%
130 [2018] % 11% 16% 10% 3% [2018] [2018] % % 15%
131
132
133 < > [2012] [2014] [2015] % 50% 126
134 (i) (ii) (iii) (iv) % GMP GMP 127
135 FDA FDA GMP
136 PMDA AAA
137 , East Pearl Holdings Limited 40.0%39.0%15.0%5.5% 0.5% East Pearl Holdings Limited East Pearl Holdings Limited 42.2% 40.0%11.0%5.8% 1.0% 130
138 ,000, % 30.0% 70.0% 30.0% % 30.0% ,000, % % % 131
139 ,000, % ,000, ,000, % 30.0% ,000, ,000, ,000, % 49% 132
140 ,000,000 [ ] [ ] Stellar Infinity 81 81% Apex Medical 19 19% Stellar Infinity Sunrise Investment Sunrise Investment Sunrise 2. [ ] Fortune Peak Fortune Peak Fortune Peak 100 Fortune Peak Fortune Peak Fortune Peak Fortune Peak 133
141 Fortune Peak 100% 3. Sunrise Sunrise Sunrise Investment 1 Sunrise Stellar Infinity Sunrise Investment [ ] Sunrise Investment Stellar Infinity 81% East Pearl Holdings Limited 42.2%40.0%11.0%5.8% 1.0% (1) 10% 134
142 (1) 100% 100% 81% 19% 100% 100% 100% 100% 90% 100% 100% 70% 30% (1) Apex Medical (2) , 10% (3) 135
143
144 [2015] [ ] [ ] [ ] [ ] 179,906,705 1,412,195,
145 [ ] 3.0%[ ] [ ] [ ] [ ] [ ] (1) ,906, [ ] ,412,195, [ ] [ ] [ ]% [ ] (1) [ ] [ ] [ ] [ ] [ ] [ ] Apex MedicalStellar Infinity GL43-12 [ ] [ ] [ ] [ ] [ ] [ ] Hillhouse Capital Management, Ltd. Hillhouse CapitalHillhouse Capital 2005 Hillhouse Capital 138
146 Hillhouse Capital Hillhouse Capital [ ] TMT Hillhouse Capital 500 [ ][ ] [ ] (i) (ii)[ ] (iii) [ ] [ ] [ ] (i)[ ][ ] [ ] [ ][ ] [ ] 28 (ii) [ ] [ ][ ] [ ] [ ] [ ] [ ] HKEx- GL [ ] [ ] HKEx-GL44-12 [ ] [ ][ ] 50,000 [ ] [ ] [ ] [ ] [ ] [ ] 139
147 [ ] [ ] 140
148 (1) Apex Medical (2) Hillhouse Fund II, L.P. Hillhouse Fund III, L.P 50% Hillhouse Capital Hillhouse Fund II, L.P. Hillhouse Fund III, L.P. (3) 141
149 [ ] [ ] Sunrise () 100% Sunrise Investment () Apex Medical (1) () (2) () 100% Stellar Infinity () [ ]% [ ]% [ ]% [ ]% () 100% Fortune Peak () 100% () 100% () () 100% 100% 100% 70% 100% 51% () 100% () (3) () () () 49% () 30% (1) Apex Medical (2) [ ] [ ] [ ] (3) 142
150 (i) (ii) (iii) (iv) % %83.4%85.7% 89.8% II CMC ,
151 1,900 5,000 cgmp % 13.9% % % 8.1% % %92.7%92.6% 93.4% 28.7%27.2%25.8% 27.6% (i) (ii) (iii) (iv) %
152 Frost & Sullivan % Frost & Sullivan %2017 1, % Frost & Sullivan % % Frost & Sullivan %
153 II II Bcr-Abl HS HS HS % 2.0% % %
154 Frost & Sullivan % 45% Frost & Sullivan % 38% % C(S-HTx) HS
155 2005 Frost & Sullivan % Frost & Sullivan Bcr-Abl TKI Frost & Sullivan HS EGFR-T790M TKIHS Frost & Sullivan 2017 EGFR HS Frost & Sullivan
156 HS HS III Frost & Sullivan Frost & Sullivan , II Frost & Sullivan % 1.1 II GLP % (PPI) 149
157 Frost & Sullivan % % 75.6% ,200 1,900 5,
158 FDA cgmp FDA 2016 PMDA FDA
159 HS
160 FDA PMDA cgmp 153
161 %83.4%85.7% 89.8% %39.5%15.9% 7.8% %44.4%16.1% 5.8%
162 Frost & Sullivan % % % Frost & Sullivan % % % 45.0% Frost & Sullivan FDA FDA 2018 FDA % 24.3% % % % 155
163 Frost & Sullivan % (extrapyramidal reactions) Frost & Sullivan % % C(S-HTx) Frost & Sullivan 2.1% 156
164 Frost & Sullivan % % % Frost & Sullivan , % PMDA FDA PMDA FDA FDA % 20.5% % % % Frost & Sullivan % Frost & Sullivan % 157
165 FDA FDA FDA % 12.2% % % % Frost & Sullivan % Frost & Sullivan %2017 NCCN 158
166 % 3.9% % % % Frost & Sullivan % Frost & Sullivan
167 % 1.6% % % % Frost & Sullivan %
168 Frost & Sullivan % 2.5% % Frost & Sullivan % % Frost & Sullivan Frost & Sullivan %
169 Frost & Sullivan % % 5.4% % % % Frost & Sullivan %
170 2015 Frost & Sullivan % Frost & Sullivan % 2033 Frost & Sullivan
171 Frost & Sullivan II % % II % 5.7% Frost & Sullivan % Frost & Sullivan % Frost & Sullivan %2017 1,
172 % 5.5% % % % Frost & Sullivan % Frost & Sullivan %
173 (1) (1) HS II HS III II II II
174 (1) (1)... (VTE) (1) D2/5-HT
175 Frost & Sullivan , D2/5-HT2A Frost & Sullivan HS HS
176 HS EGFR HS EGFR T790M HS EGFR Frost & Sullivan 2017 EGFR HS II HS HS Frost & Sullivan Frost & Sullivan , Bcr-Abl TKI 169
177 Frost & Sullivan NCCN Frost & Sullivan HS HS
178 HS HS Frost & Sullivan ,818 HS III HS HS (SGLT-2) II FDA SGLT-2 Frost & Sullivan Frost & Sullivan
179 1.1 GLP-1 II Frost & Sullivan GLP-1 Frost & Sullivan 2017 GLP GLP III IV(DPP-IV) II Frost & Sullivan ,440 Frost & Sullivan
180 HT4 Frost & Sullivan Frost & Sullivan Frost & Sullivan Frost & Sullivan
181 Xa VTE Xa Frost & Sullivan Frost & Sullivan Frost & Sullivan
182 Xa Xa Xa Frost & Sullivan Frost & Sullivan Frost & Sullivan Frost & Sullivan
183 Frost & Sullivan , %7.4%9.3% 9.6% 176
184 HS
185
186
187 ,
188 181
189 ,900 5, (5) A B C GSP 182
190 %13.8%13.6% 11.6% 10 5% 2016 A B C GSP GSP GSP 183
191 (i) (ii) 0.2% GSP 184
192 2013 FDA 2012 FDA FDA 2018 FDA 2016 PMDA 185
193 (i) (ii) (iii)
194 GMP GMP cgmp 187
195 188
196 189
197 GMP cgmp 190
198 (1) (%) (1) (%) (1) (%) (1) (4) (%) (2)... 2,620 1, % 2,620 1, % 2,620 1, % 4,000 1, % (3) % % % %
199 50,000 25, , , ,000 23,
200 (1) (2) (3) , [ ] [ ] [ ] 193
201 %36.3%31.6% 25.1% %16.2%7.3% 7.2% % 35(b) 194
202 GMP 2003 FDA PMDA EDQM KFDA GMP (ICH) 195
203 GMP 196
204
205 198
206 , ,417 6, , , % 15% 32L 6(2) 342(1)(b) 34(2) 199
207 200
208 201
209 AA GSP (A-JS15-163) GMP (JS ) GMP (JS ) GMP (JS ) GMP (JS ) GMP (JS ) GMP (JS ) GMP (JS )... HS
210 GMP (JS ) GMP (JS ) GMP (JS )... HS GMP (JS ) GMP (JS )... HS102 HS GMP (JS ) GMP (JS ) GMP (JS ) GMP (JS ) GSP GMP (JS ) GMP (JS ) 203
211 , %... 1, %... 1, % %... 4, %... 1, %... 7, % 204
212 GMP GMP GMP 205
213
214 (i) (ii) (iii) (iv) % % % 89.8%
215 II ,200 1,900 5,000 cgmp % 13.9% % % 8.1% % %92.7%92.6% 93.4% 28.7%27.2%25.8% 27.6% 208
216 (i) (ii) (iii) (iv) %88.8% 90.4% % % %12.5%9.8%8.9% 9.6% % % % 209
217 Frost & Sullivan %13.5% 13.8% 8.0% % % II
218
219 %83.4%85.7% 89.8% 212
220 %7.3%7.4% 6.6% %43.8% % 213
221
222
223 3 216
224 % % % % %... 5,045, ,432, ,185, ,974, ,774, (374,573) (7.4) (397,279) (7.3) (455,171) (7.4) (213,473) (7.2) (250,192) (6.6)... 4,670, ,035, ,730, ,761, ,524, , , , , , (2,240,230) (44.4) (2,378,040) (43.8) (2,704,200) (43.7) (1,308,407) (44.0) (1,558,557) (41.3)... (454,719) (9.0) (537,972) (9.9) (614,075) (9.9) (284,056) (9.5) (368,292) (9.8)... (408,980) (8.1) (403,065) (7.4) (575,544) (9.3) (256,126) (8.6) (362,609) (9.6)... 42, , , , (6) (0.0) (3,411) (0.1)... 1,690, ,804, ,932, , ,278, (241,642) (4.8) (328,244) (6.0) (337,318) (5.5) (169,146) (5.7) (235,724) (6.2)... 1,448, ,476, ,595, , ,042,
225 % % % % %... 1,463, ,473, ,681, , , ,761, ,026, ,443, ,126, ,674, , , , , , , , , , , , , , , , , , , , , ,045, ,432, ,185, ,974, ,774, %81.6% 81.8% % 79.2% % % % % % , , , , , , , , , , , , , , , , , , , , , , , , ,
226 %7.3%7.4% 6.6% 50.7%48.1%46.8% 46.0% %92.7%92.6% 93.4% ,674 6,438 12,815 5,193 8, ,889 64,725 54,307 9,186 12, ,745 4,682 22,371 16,615 14, ,965 2,645 1, ,811 7,319 2, ,491 85,811 93,230 32,169 35,
227 , ,004 7,481 8,338 2,402 10, (5,298) (6,212) (7,431) (4,136) (9,127) ,210 (4,689) (3,616) 2, (369) (2,033) 2,708 1,776 1, ,052 3,557 3,618 1,624 42,076 5,274 3, ,541 (i) (ii) (iii) (iv) % % % % %... 1,823, ,894, ,119, ,035, ,227, , , , , , , , , , , , , , , , ,240, ,378, ,704, ,308, ,558,
228 (i) (ii) (iii) (iv) (v) (vi) (vii) % % % % % , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , (i) (ii) (iii) (iv) v 221
229 % % % % % , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,872 72,025 93,035 37,777 46, , , , , ,
230 16.5% % % % o %
231 % o % (i) (ii) o % o , % o ,970 2, % , %
232 o , % , % o , % , % o , % , % ,
233 % % % , % , , % , % , , % ,270 2,670 2,
234 % % % % % % % o %
235 % % o % o % o , % o ,660 2, % , % % o , %
236 % o % o , % (i) 2,170 (ii) 990 (iii) 1, % % % 229
237 2016 8, % ,320 1, , % , ,470 1, % , % (i) (ii) 7, , % , % , % ,850 7,280 4,
238 % % % % % % % o %
239 % % o % o , % o , % o ,520 3, % , % % o ,970 8, %
240 % % o % % o , % , % (i) 150 (ii) 650 (iii) % % % , % ,
241 1,770 1, % , % , % ,130 4, , % ,560 1, % ,410 2, ,210 3, % ,
242 , % % % , % [ ] [ ] [ ] ,145,471 1,246,507 1,402, , , (594,707) 829,538 (614,271) 91,544 (670,417)... (606,962) (2,048,558) (730,475) (404,134) 235
243 (i) (ii) 6,970 (i) (ii) (iii) 6, (i) (ii) (i) (ii) (iii) 7, (i) (ii) (i) (ii) (iii) 9, (i) (ii) (i) (ii) , (i) (ii) (iii) (i) (ii) (i) (ii)
244 (i) (ii) (i) (ii) (i) (ii) (i) (ii) ,
245 , , , , , ,468,407 1,723,535 2,192,518 2,809,253 2,636, ,250 42,962 62, , , ,024, , , ,400 1,118, , , , , , , , , , , , ,185,194 3,463,699 4,417,867 5,700,773 5,807, ,210 44,908 98, , , ,282,578 1,256,582 1,024,006 1,208,849 1,228, ,587 56,057 41,512 44,592 28, , ,404 50,283 63,362 60,314 17, ,789, ,134 4,000, ,307,911 1,811,964 1,227,674 1,497,400 5,485, (1,122,717) 1,651,735 3,190,193 4,203, , (i) (ii)
246 (i) (ii) (i) (ii) 8, (i) (ii) (iii) , (i) (ii) (i) (ii) ,941 63,541 82, , , , , , ,443 65, , , , , , ,
247 % , % , % , (1) (2) (3) (1) 365 (2) 365 (3)
248 ,669,298 1,591,546 1,384,346 1,684, (18,127) (19,253) (12,598) (9,860) 1,651,171 1,572,293 1,371,748 1,675, , , ,770 1,134,179 2,468,407 1,723,535 2,192,518 2,809, (1) (1)
249 ,539,675 1,447,414 1,343,096 1,640, , ,202 23,030 30, ,853 6,677 5,622 4, ,651,171 1,572,293 1,371,748 1,675, , , , , ,509 39, , , ,800 2, , , ,770 1,134,
250 ,261 16,462 2,568 8, ,210 44,908 92,454 78, , ,848 58,210 44,908 98, , ,820 4,490 9,
251 (1) (1) ,260 43,306 90, , ,627 78, , , ,210 44,908 98, ,
252 ,482 48,150 32,784 56, , , , , , , , , , , , , ,197, ,504 8, , , , , ,282,578 1,256,582 1,024,006 1,208, (1)... 19,629 1,251 1, (2)... 2,005, , , ,661 2,024, , , ,400 (1) 245
253 (2) 1.35% 5.10% , , , , ,492 4, ,
254 ,617 64,516 33,355 11,883 2, ,292 9, , ,860 6,450 3, , ,
255 ,788 18,802 81,214 6, ,385 65,029 73,096 63,111 9,178 9,436 10,643 6,388 7,369 8,974 4,607 2,309 78,040 74,318 96, ,182 3,542 5,662 6, , , , , ,
256 , , , , , , %
257 (1) (2) (%) (3) (1) (2) 100% (3) 250
258
259 [ ] 10% 10% 50% [ ] [ ] [ ]
260 [ ] ,571,827,000 13,733, [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 3. [ ] [ ] 4. [ ]
261 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ]
262 [ ] (1)(4) (2) (3)(4) [ ] [ ] [ ] [ ] [ ] [ ] (1) (2) (3) (4)
263 FDA PMDA EMBA 256
264
265 Hillhouse Capital Management Ltd [ ] Tetrahedron/Tetrahedron Letters
266 [ ] [ ]
267 CYOU [ ] (i) (ii) 13.51(2) (iii) 260
268
269 Curis Inc
270
271
272 [C. 2. ] [ ] [ ] [ ] [ ] D.[ ] [ ] [ ] 3A.19 (i) [ ] [ ] [ ]
273 (ii) [ ] 3A.23 A [ ][ ] (iii) (iv) (v) 14 A
274 A.4.4 [ ] 267
275 [ ] Stellar Infinity [ ] [ ]% [ ] Stellar Infinity Sunrise Investment Sunrise Investment Sunrise Sunrise Sunrise Stellar Infinity Sunrise Investment [ ] Stellar Infinity Sunrise Investment [24.17]% Frost & Sullivan 4,000 Frost & Sullivan Frost 268
276 & Sullivan Frost & Sullivan %1.36%1.02% 0.66% 8.10 [ ] Sunrise Investment Stellar Infinity Sunrise Investment Stellar Infinity [ ] 269
277 (i) (ii) (iii) (iv) 270
278 [ ] (a) (b) (c) (d) ,
279 (e) (f) ,000 (g) B. 2. (h) (i) ,000 6,292,000 9,008, , %1.58%1.98% 0.08% 272
280 273
281 10% 10% 30% [ ][ ] 274
282 (a) (b) (c) 275
283 (d) (e) (f) (g) (h) (i) 276
284 (j) 277
285 [ ] [ ] [ ] [ ] 950, , , , [ ] 20,000,000, ,000 [ ] [ ]... 50,000 [ ] [ ] [ ] [ ]... [ ] [ ] [ ] [ ]... [ ] [ ] [ ] [ ] [ ] [ ] [ ] 278
286 [ ] (a) (b) (c) (i) [ ] 20% (ii) (1) (2) (3) A
287 [ ] [ ] 10% A. 7. (i) (ii) (iii) A
288 [ ] [ ] XV 2 3 [ ] 10% [ ] [ ] (1) Stellar Infinity (2)... 3,900,000,000 78% [ ] [ ] Sunrise Investment (2)... 3,900,000,000 78% [ ] [ ] Sunrise Trust (2)... 3,900,000,000 78% [ ] [ ] (2)... 3,900,000,000 78% [ ] [ ]... 3,900,000,000 78% [ ] [ ] Apex Medical ,000,000 19% [ ] [ ] (4) ,000,000 19% [ ] [ ] (1) [ ] (2) Stellar Infinity Sunrise Investment Sunrise Investment Sunrise Trust (3) Apex Medical [ ] [ ] [ ] XV 2 3 [ ] 10% 281
289 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ][ ] [ ] [ ] (i) [ ][ ] [ ] (ii) [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 282
290 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 283
291 [ ] [ ] 284
292 [ ] [ ] 285
293 [ ] [ ] 286
294 [ ] [ ] 287
295 [ ] [ ] 288
296 [ ] [ ] 289
297 [ ] [ ] 290
298 [ ] [ ] 291
299 [ ] [ ] 292
300 [ ] [ ] 293
301 [ ] [ ] 294
302 [ ] [ ] 295
303 [ ] [ ] 296
304 [ ] [ ] 297
305 [ ] [ ] 298
306 [ ] [ ] 299
307 [ ] [ ] 300
308 [ ] [ ] 301
309 [ ] [ ] 302
310 [ ] [ ] 303
311 [ ] [ ] 304
312 [ ] [ ] 305
313 [ ] [ ] 306
314 [ ] [ ] 307
315 [ ] [ ] 308
316 [ ] [ ] 309
317 [ ] [ ] 310
318 [ ] [ ] 311
319 [ ] [ ] 312
320 [ ] [ ] 313
321 [ ] [ ] 314
322 [ ] [ ] 315
323 [ ] [ ] 316
324 [ ] [ ] 317
325 [ ] [ ] 318
326 [ ] [ ] 319
327 [ ] [ ] 320
328 [ ] [ ] 321
329 [ ] [ ] 322
330 [ ] [ ] 323
331 [ ] [ ] 324
332 [ ] I-5 I I-5 I-70 [ ] [ ] I-1
333 I-2
334 I-4 12 [ ] I-3
335 I. I-4
336 ,045,174 5,432,960 6,185,537 2,974,855 3,774, (374,573) (397,279) (455,171) (213,473) (250,192)... 4,670,601 5,035,681 5,730,366 2,761,382 3,524, ,491 85,811 93,230 32,169 35, (2,240,230) (2,378,040) (2,704,200) (1,308,407) (1,558,557)... (454,719) (537,972) (614,075) (284,056) (368,292)... (408,980) (403,065) (575,544) (256,126) (362,609) ,076 5,274 3, , (6) (3,411) ,690,233 1,804,278 1,932, ,252 1,278, (241,642) (328,244) (337,318) (169,146) (235,724)... 1,448,591 1,476,034 1,595, ,106 1,042, ,448,591 1,476,034 1,595, ,106 1,042,307 1,448,591 1,476,034 1,595, ,106 1,042, I-5
337 ,448,591 1,476,034 1,595, ,106 1,042, ,387 (51,121) (19,050) 10, ,387 (51,121) (19,050) 10, ,387 (51,121) (19,050) 10, ,448,591 1,551,421 1,544, ,056 1,053, ,448,591 1,551,421 1,544, ,056 1,053,137 1,448,591 1,551,421 1,544, ,056 1,053,137 I-6
338 ,337 1,048,085 1,171,490 1,304, , , , , ,693 6,061 9,178 13, , , , , , ,245,285 1,357,252 1,456,181 1,542, , , , , ,468,407 1,723,535 2,192,518 2,809, ,250 42,962 62, , ,024, , , , , , , , , , , , , ,185,194 3,463,699 4,417,867 5,700, ,210 44,908 98, , ,282,578 1,256,582 1,024,006 1,208, ,587 56,057 41,512 44, , ,404 50,283 63,362 60, ,789, , ,307,911 1,811,964 1,227,674 1,497, (1,122,717) 1,651,735 3,190,193 4,203, ,568 3,008,987 4,646,374 5,745, , , , , , , ,568 2,974,338 4,518,690 5,571, ,568 2,974,337 4,518,689 5,571, ,568 2,974,338 4,518,690 5,571, ,568 2,974,338 4,518,690 5,571,827 I-7
339 * * * * * , ,048 3,842,151 4,434,919 4,434, ,448,591 1,448,591 1,448, ,550 (18,550) ,302 (493,302) ,690 (406,690)... (167,100) (167,100) (167,100)... (767,436) (767,436) (767,436) (168,176) (1,908) (633,322) (803,406) (803,406) (4,023,000) (4,023,000) (4,023,000) (55,000) 55, , , , ,476,034 1,476,034 1,476, ,387 75,387 75,387 75, ,302,448 1,302,449 1,302, ,000 (150,000)... (2,100) (2,100) (2,100) ,302,448 (57,100) 75, ,000 1,448,602 2,974,338 2,974,338 I-8
340 * * * * * ,302,448 (57,100) 75, ,000 1,448,602 2,974,338 2,974, ,595,473 1,595,473 1,595, (51,121) (51,121) (51,121) ,302,448 (57,100) 24, ,000 3,044,075 4,518,690 4,518, ,042,307 1,042,307 1,042, ,830 10,830 10, ,302,448 (57,100) 35, ,000 4,086,382 5,571,827 5,571, ,302,448 (57,100) 75, ,000 1,462,374 2,988,110 2,988, , , , (19,050) (19,050) (19,050) ,302,448 (57,100) 56, ,000 2,224,708 3,731,394 3,731,394 * ,568,000 2,974,337,000 4,518,689,000 5,571,826,000 I-9
341 ,690,233 1,804,278 1,932, ,252 1,278, ,033 (2,708) (1,776) (1,091) , , ,382 62,776 69, ,316 2,265 2,667 1,374 1, ,618 3,679 3,964 2,334 3, (1,444) (776) (531) (246) (606)... (3,155) 10,624 (2,395) (222) (2,179)... 5 (59,523) (24,542) (18,758) (7,373) (16,468)... 5 (407) (2) (2) (2) (8) ,411 1,738,718 1,916,328 2,046,410 1,002,117 1,331, (69,674) (691,990) (466,275) (703,424) (615,644)... 69, ,547 (16,754) (41,796) (16,089)... (64,362) (95,021) (78,397) (57,017) (60,638)... 72,144 (13,302) 53,886 17,836 84, (318,438) (51,185) 109, , , ,157 33,470 (14,545) (31,635) 3, ,441,981 1,557,847 1,633, , , (296,510) (311,340) (231,204) (133,408) (192,418)... 1,145,471 1,246,507 1,402, , ,672 I-10
342 ,194 2,767 3,400 1,278 2, (1,154,500) (1,600,034) (905,742) (582,735) (558,909)... 1,529, , , , , (11,050,900) (3,173,100) (3,839,000) (1,393,000) (2,925,000)... 10,292,500 4,903,100 3,502,000 1,589,000 2,593, ,407 2,144 10,149 6,657 10, ,849 18,104 5,943 2,179 8, (97) , (367,000) , (28,901)... (239,634) (238,926) (256,346) (108,907) (145,453)... (3,542) (5,662) (6,741) (5,665) (158)... (14,628) 15, (20,000) 30, (594,707) 829,538 (614,271) 91,544 (670,417) I-11
343 , , (450,000) (12,730) (647,489)... 1,302, (644,232) (2,368,507) (404,134) (404,134)... (167,200) (2,000)... (114,394) (324,341)... 7 (3,417)... (606,962) (2,048,558) (730,475) (404,134)... (56,198) 27,487 57,506 49,950 26, , , , , , , , , , , , , , , , , , ,470 11,726 9,519 33,763 3, , , , , ,816 I-12
344 , , , , , ,813 10,475 16,401 36,458 5,078 7,744 5, , , ,158 59,114 26,252 17, , , , , , , ,404,942 1,336,101 1,361, ,404,942 1,336,101 1,361, ,404,941 1,336,100 1,361, ,404,942 1,336,101 1,361,388 I-13
345 II. 1. Maples Corporate Services Limited, PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman Islands (i)... (i)... (iv)... (ii)... Fortune Peak Company Ltd. Fortune Peak(iv) ,000, % % 10,000, % 1,000, % 260,000, % I-14
346 (iii)... (i) % % 2,000,000 (i) (ii) (iii) (iv) Fortune Peak I-15
347 (a) (b) (c) I-16
348 (i) (ii) (iii) (i) (ii) (iii) (2011) I-17
349 , I-18
350 I-19
351 (a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) (vi) (a) I-20
352 (vii) (a)(i) (viii) I-21
353 ... 3 I-22
354 (a) (b) (c) I-23
355 (a) (b) % % % I-24
356 12 9 I-25
357 I-26
358 I-27
359 (a) I-28
360 (b) (c) (d) (e) I-29
361 ,958,000 I-30
362 8,680,000 7,393,000 14,432, , ,000 1,523, , I-31
363 % 5 I-32
364 ,045,174 5,432,960 6,185,537 2,974,855 3,774, ,674 6,438 12,815 5,193 8, ,889 64,725 54,307 9,186 12, ,745 4,682 22,371 16,615 14, ,965 2,645 1, ,811 7,319 2, ,491 85,811 93,230 32,169 35, , ,004 7,481 8,338 2,402 10, (5,298) (6,212) (7,431) (4,136) (9,127) ,210 (4,689) (3,616) 2, (369) (2,033) 2,708 1,776 1, ,052 3,557 3,618 1,624 42,076 5,274 3, ,541 I-33
365 , , , , , , , ,382 62,776 69, ,316 2,265 2,667 1,374 1, ,618 3,679 3,964 2,334 3, ,033 (2,708) (1,776) (1,091)... 1,857 3,687 2,879 1, , , (1,444) (776) (531) (246) (606)... 5 (407) (2) (2) (2) (8)... 5 (17,674) (6,438) (12,815) (5,193) (8,067)... 5 (45,004) (7,481) (8,338) (2,402) (10,579) , , , , , , , ,679 85, , , , , , ,106 I-34
366 , ,956 19,397 25,212 12,886 14, ,021 19,604 25,431 12,997 14,300 I-35
367 (i) 2, , (ii) 2, , (i) 14, , (ii) 3, , (iii) 1, ,723 19, , (iv) 19, , (i) 17, , (ii) 5, , (iii) 2, ,522 25, , (iv) 25, ,431 I-36
368 (i) 10, , (ii) 3, , (iii) , , (iv) 14, , , , , , , , , ,997 (i) (ii) (iii) (iv) I-37
369 ,576 2,169 2, ,836 2,307 2, ,000, ,000,000 1,500, ,500,000 2,000, I-38
370 % 2015 HNTE , , , , , ,872 72,025 93,035 37,777 46, , , , , ,724 I-39
371 ,690,233 1,804,278 1,932, ,252 1,278, , , , , , (154,707) (164,011) (168,445) (84,724) (120,917) (34,935) (39,910) (71,933) (28,015) (27,842)... 4,978 (361) 1,119 1,119 3, (1,997) (5,127) (632) (2) (8)... 1,552 7,270 8,051 2,442 5, ,446 78,374 84,438 41,173 55, , , , , , , ,023,000, I-40
372 14 I ,457 5, ,881 56,083 55,135 76,134 1,298, (95,791) (1,897) (160,762) (31,703) (39,400) (329,553) ,666 3, ,119 24,380 15,735 76, , ,666 3, ,119 24,380 15,735 76, , , ,385 9,178 7,369 78, , (589) (2,133) (28) (2,750)... 57,509 1,713 1,499 (60,721)... (37,002) (1,479) (60,957) (10,149) (5,907) (115,494) ,372 2, ,127 24,880 17,197 93, , ,993 5, ,154 64,982 52,338 93,453 1,421, (132,621) (3,375) (215,027) (40,102) (35,141) (426,266) ,372 2, ,127 24,880 17,197 93, , ,993 5, ,154 64,982 52,338 93,453 1,421, (132,621) (3,375) (215,027) (40,102) (35,141) (426,266) ,372 2, ,127 24,880 17,197 93, , ,372 2, ,127 24,880 17,197 93, , ,802 65,029 9,436 8,974 74, , (1,078) (346) (108) (459) (1,991)... 28,954 6,344 44,379 2,564 (82,241)... (38,171) (2,552) (61,493) (12,727) (6,877) (121,820) ,879 6, ,696 24,045 18,835 85,530 1,048, ,951 12, ,937 77,278 56,553 85,530 1,584, (169,072) (5,927) (270,241) (53,233) (37,718) (536,191) ,879 6, ,696 24,045 18,835 85,530 1,048,085
373 ,951 12, ,937 77,278 56,553 85,530 1,584, (169,072) (5,927) (270,241) (53,233) (37,718) (536,191) ,879 6, ,696 24,045 18,835 85,530 1,048, ,879 6, ,696 24,045 18,835 85,530 1,048, ,214 73,096 10,643 4,607 96, , (1,715) (136) (86) (932) (2,869)... 7,026 1,144 42,349 1,055 (51,914) (340)... (43,432) (3,302) (72,148) (12,681) (7,726) (139,289) ,972 3, ,857 22,976 15, ,027 1,171, ,557 13, ,567 77,523 59, ,027 1,826, (210,585) (9,229) (336,710) (54,547) (43,743) (654,814) ,972 3, ,857 22,976 15, ,027 1,171, ,557 13, ,567 77,523 59, ,027 1,826, (210,585) (9,229) (336,710) (54,547) (43,743) (654,814) ,972 3, ,857 22,976 15, ,027 1,171, ,972 3, ,857 22,976 15, ,027 1,171, ,410 63,111 6,388 2, , , (161) (69) (812) (549) (1,591)... 58,236 91,675 4,820 (162,374) (7,643)... (26,460) (1,267) (38,655) (6,167) (3,841) (76,390) ,997 2, ,919 28,017 13, ,286 1,304, ,006 13, ,434 88,130 59, ,286 2,023,701 (230,009) (10,496) (372,515) (60,113) (46,302) (719,435) 713,997 2, ,919 28,017 13, ,286 1,304,266 I-42
374 ,763, I , (2,316) , (2,222)... 94, , , (2,265) , (2,667) , , (2,667) , (2,667) , , (1,334) , (2,666) ,293
375 , (2,445)... 3, , (2,618) , , (5,063)... 4, , (5,063)... 4, , (615)... (3,679) , , (8,130)... 6,061 I-44
376 , (8,130)... 6, , (3,964) , , (12,095)... 9, , (12,095)... 9, , (3,246) , , (15,341)... 13,733 I-45
377 ,010 2,742 36,164 6,934 3, , (652) (803) (1,455) ,951 (29,855) 3, ,056 (16,996) ,958 8,041 6,309 9,988 3,661 2,295 42, (3,278) 11,444 (4,955) 2, ,845 7, ,680 19,485 1,354 12,700 3,833 4,140 50, (1,287) (4,296) (24) 1,859 (1,262) (896) (5,906) ,393 15,189 1,330 14,559 2,571 3,244 44, ,039 (3,253) (380) 5,843 (533) (987) 7, ,432 11, ,402 2,038 2,257 52,015 I-46
378 (1,430) (3,446) (4,876) (1,430) (3,446) (4,876)... (1,591) (78,374) (79,965) (3,021) (81,820) (84,841)... (2,691) (84,438) (87,129) (5,712) (166,258) (171,970) (55,082) (54,083) (4,713) (221,340) (226,053) ,958,000 8,680,000 7,393,000 14,432, , ,000 1,523, , I-47
379 ,941 63,541 82, , , , , , ,443 65, , , , , , , ,669,298 1,591,546 1,384,346 1,684, (18,127) (19,253) (12,598) (9,860) 1,651,171 1,572,293 1,371,748 1,675, , , ,770 1,134,179 2,468,407 1,723,535 2,192,518 2,809, ,539,675 1,447,414 1,343,096 1,640, , ,202 23,030 30, ,853 6,677 5,622 4,192 1,651,171 1,572,293 1,371,748 1,675,074 I-48
380 , , , , ,509 39, , , ,800 2, , , ,770 1,134, ,261 16,462 2,568 8, ,439, ,333, ,535,000 37,137,000 I-49
381 ,837 9,383 15,112 30, ,222 2,667 2,667 2, ,396 4,588 4,590 5, ,139 10,142 19,157 23, , , ,078 7,744 5, ,680 11,104 13,112 8, ,250 42,962 62, , (a) 19,629 1,251 1, (b) 2,005, , , ,661 2,024, , , ,400 (a) (b) 1.35% 5.10% , , , ,158 I-50
382 , , , , ,470 11,726 9,519 3, , , , , , , , , ,585 72,119 54,933 64, , , , , ,210 44,908 92,454 78, , ,848 58,210 44,908 98, ,645 I-51
383 ,260 43,306 90, , ,627 78, , ,042 58,210 44,908 98, , ,482 48,150 32,784 56, , , , , , , , , , , , , ,197, ,504 8, , , , ,181 2,282,578 1,256,582 1,024,006 1,208, ,587 56,057 41,512 44,592 I-52
384 , , ,789,132, ,134, , ,580, I-53
385 (i) 10% 50% 25% (ii) ,458, I-54
386 ... 1, , , , , (50,633)... (10,327)... 58, , (12,730)... (12,730) , , , , , , , (647,489)... (647,489) I-55
387 32 (a) 19 (b) , , ,000 50, (644,232) (644,232)... 50,000 (644,232) (594,232) , , , , , , ,023,000 4,023, (88,719) 88, ,934,281 1,306,709 5,240, ,000 3,789,132 1,307,626 5,146,758 I-56
388 ,000 3,789,132 1,307,626 5,146, , , (450,000) (450,000)... (3,417) (3,417)... (647,489) (647,489)... (135,557) (135,557)... (110,597) (110,597)... (2,278,871) (89,636) (2,368,507)... (50,000) (2,278,871) (986,696) (3,315,567)... 2,000 2, (1,106,127) (1,106,127)... 3,411 3, (1,106,127) 5,411 (1,100,716) , , , (324,341) (324,341)... (2,000) (2,000)... (404,134) (404,134)... (404,134) (326,341) (730,475) , , , (404,134) (404,134)... (404,134) (404,134) , ,341 I-57
389 , , , , ,361 I-58
390 35 (a) East Pearl Holdings Limited East Pearl I-59
391 (b) ,492 4, , ,617 64,516 33,355 11,883 2, ,292 9, , , I-60
392 (c) (i) , ,000 92, ,000 (ii)... 46, ,797 46, , ,489 East Pearl , , , , ,104 8, , ,667 4,756 1,197, ,504 8, ,612,152 East Pearl... 1,359, , , , ,079 15,134 3,789, ,134 I-61
393 (d) ,267 28,870 35,734 16,348 17, , ,123 29,849 36,773 16,874 18, ,809,253 2,809, , , ,450 76, , , , , ,400 4,244,573 4,980,077 I-62
394 ,192,518 2,192, , , ,382 62, , , , , ,722 3,370,790 3,978, ,723,535 1,723, , , ,962 42, , , , , ,327 2,842,321 3,110, ,468,407 2,468, ,024,776 2,024, , , ,000 30, , , , ,192 2,024,776 2,908,849 4,933,625 I-63
395 ,210 44,908 98, , ,826, , , , ,789, , ,000 5,723,824 1,304, , , I-64
396 , , , , , , , , ,629 2,005,147 2,024, I-65
397 (a) 27 (b) % ,424 1, (5) (1,424) (1,210) , (5) (1,097) (932) (5) (420) (357) (5) (379) (322) I-66
398 (c) (d) I-67
399 , , , , , , , , ,794 98, , , , , ,908 44, , ,134 1,304,933 1,304,933 I-68
400 ,826,482 1,826, ,210 58, ,000 50, ,789,132 3,789,132 5,723,824 5,723,824 (e) ,307,911 1,846,613 1,355,358 1,671, ,430,479 4,820,951 5,874,048 7,243, % 38% 23% 23% I-69
401 ,000,000, I-70
402 A [ ] [ ] [ ] [ ] [ ] [ ] [ ]... 5,558,094 [ ] [ ] [ ] [ ] [ ] [ ]... 5,558,094 [ ] [ ] [ ] [ ] ,571,827,000 13,733,000 II-1
403 2. [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 3. [ ] [ ] [ ] 4. [ ] 1.00 II-2
404 [ ] II-3
405 [ ] II-4
406 [ ] II-5
407 1 [ ] 2 [ ] 2.1 [ ] [ ] (a) III-1
408 (b) (c) (d) (e) III-2
409 (f) (i) (ii) (iii) III-3
410 (iv) (A) (B) (v) (g) III-4
411 (h) (i) III-5
412 (ii) (iii) 12 (iv) (v) (vi) (vii) (i) (j) III-6
413 (a) III-7
414 (b) (c) 2.6 III-8
415 2.7 III-9
416 % 2.9 III-10
417 III-11
418 (a) (b) 95% 2.11 (a) (b) (c) (d) (e) (f) III-12
419 III-13
420 (a) (b) III-14
421 III-15
422 III-16
423 III-17
424 III-18
425 2.21 (a) 12 (b) (d) (c) 12 (d) III-19
426 (a) (b) (c) 37 (d) (e) (f) III-20
427 Foss v. Harbottle (a) (b) (c) 6 III-21
428 7 8 (a) (b) (c) 9 III-22
429 (a) (b) (a) (b) III-23
430 14 75% 15 90% 16 III-24
431 17 (a) (b) (a) (b) (i) (ii) (3) 20 III-25
432 21 III-26
433 A , , , Mapcal Limited 0.01 Mapcal Limited Apex Medical (i) Stellar Infinity (ii) Apex Medical 0.01 Stellar Infinity (i)stellar Infinity (ii)apex Medical IV-1
434 Apex Medical 1, Stellar Infinity 7, Stellar Infinity , , , (i) Stellar Infinity 7, (ii) Apex Medical 1, (iii) [ ] 20,000,000, , , , , ,000 (i)950, , (ii)20,000,000, [ ] [ ]10,000 [ ] 10, , , ,000 20,000,000, [ ] [ ] 50,000 [ ] [ ] [ ] [ ] [ ] [ ] [ ] IV-2
435 ,000, ,000, [ ] (a) [ ] (b) 20,000,000, , , , , ,000 (i)950, , (ii)20,000,000, (c) (d) [ ] 10,000 (e) 950, , ,000 20,000,000, , (f) (b) (e) [ ] [ ] 50,000 [ ] IV-3
436 [ ] [ ] [ ] (g) [ ] (i) [ ] [ ] (ii) [ ] (iii) [ ] [ ] [ ] (h) [ ] [ ] [ ] 20% IV-4
437 (i) [ ] [ ] 10% (j) (f) (g) (k) [ ] [ ] 5. [ ] 6. II 1 7. (a) [ ] (i) [ ] IV-5
438 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 10% (ii) [ ] [ ] [ ] [ ] (iii) [ ] [ ] [ ] [ ] 10% 30 [ ] [ ] [ ] 5% IV-6
439 (iv) (v) (i) (ii) (vi) 30 (vii) IV-7
440 (b) [ ] (c) [ ] [ ] [ ] [ ] [ ] (1) (2) (3) (d) [ ] [ ] IV-8
441 26 25% B. 1. (a) [ ] (b) [ ] 2. IV-9
442 (a) IV-10
443 IV-11
444 IV-12
445 IV-13
446 IV-14
447 IV-15
448 IV-16
449 IV-17
450 IV-18
451 IV-19
452 IV-20
453 IV-21
454 IV-22
455 IV-23
456 IV-24
457 , , , , , , , , , IV-25
458 , , , , , , , , , IV-26
459 A A A A IV-27
460 IV-28
2018 Hope Education Group Co., Ltd
2018 Hope Education Group Co., Ltd. 2018 7 14 2018 8 3 1 2018 Hope Education Group Co., Ltd. 2018 7 14 2018 8 3 2 2018 Hope Education Group Co., Ltd. 2018 7 14 2018 8 3 1 Hope Education Group Co., Ltd.
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此乃要件 請即處理 閣下如對本通函任何方面或應採取的行動有任何疑問 應諮詢 閣下的股票經紀 其他持牌證 券商 銀行經理 律師 專業會計師或其他專業顧問 閣下如已售出或轉讓名下所有金嗓子控股集團有限公司的股份 應立即將本通函連同隨附的代 表委任表格送交買主或承讓人 或經手買賣的銀行 股票經紀或其他代理人 以便轉交買主或 承讓人 香 交易及結算所有限公司及香 聯合交易所有限公司對本通函的內容概不負責 對其準確性
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