(1)... (2) (3)... (4)... elpo (5) ( ( (6)...
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- 井 寇
- 7 years ago
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1
2 CHINA MEDICAL SYSTEM HOLDINGS LIMITED * 200,000,000170,000,000 30,000,000 20,000, ,000,000150,000,000 30,000, % 0.004%0.005% C % 0.004%0.005% *
3 (1)... (2) (3)... (4)... elpo (5) ( ( (6)...
4 (1) eipo (7) (1) (2) 9. (3) 5. (4) (5) (6) (7)
5
6 ... I-1... II-1... III-1... IV-1... V-1... VI-1... VII-1
7 Frost & Sullivan 18% ,000 97% 86% 91.5% 34.6% 100,000 CNS 35,000 40, % 79.6% 75.5% 70.2% 90.9% 95.1% 96.2% 94.0% Frost & Sullivan 28.8% 47.6%
8 100% Dr. Falk Pharma GmbH Frost & Sullivan * *
9 Frost & Sullivan 21.9%5% 20.7% 1,107 Frost & Sullivan 38% Frost & Sullivan % Frost & Sullivan 46Frost & Sullivan UDCA 98.0% 55.9% (AMD)
10 rhbnp (AAD) 11.9% 16.3% 21.9% 22.9% 35.3% 25.4% 38.0% 32.4% 300 6,
11 % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,200 CMSH % 30.8% %
12 25.6% 64.9% 61.7% 63.1% 60.8% % 45.2%16.8% 20.7% 21.6% 25.1%
13 84.1% 85.2% 82.3% 76.2%
14 % 50.6% 46.1% 42.5% % 5.4% 5.0% 3.3% (i) (ii) (iii) (iv)
15 CMS024CMS024
16
17 1
18 ... 51,747 72,600 96,454 46,775 61, (18,149) (27,835) (35,596) (17,139) (23,970)... 33,598 44,765 60,858 29,636 37, ,280 2, (13,934) (18,631) (24,840) (11,366) (13,318)... (2,773) (1,221)... (5,947) (6,940) (7,399) (3,908) (3,274)... (1,633) (2,275) (2,038) (1,057)... (301) (226) (390) (191) (336) (26) ,346 19,535 26,926 13,800 19, (1,672) (4,487) (6,096) (3,243) (4,355)... 8,674 15,048 20,830 10,557 15, ,639 2, (1) (5)... (145) ,313 17,964 20,754 10,576 15, ,685 14,946 20,684 10,448 15, (11) ,674 15,048 20,830 10,557 15, ,335 17,877 20,608 10,467 15, (22) ,313 17,964 20,754 10,576 15,858
19 ... 10,677 5,945 11,060 17, ,305 27,684 32,794 41, ,060 17,641 17, ,601 20,100 15,113 10,340 47,767 55,004 77,120 88, ,920 9,252 11,062 12, ,517 16, ,226 1,848 13,100 10,755 29,788 31, ,667 44,249 47,332 56,937 (1) (2)
20 2. 1,123,691, (1)... 4,045 5,686 (2) (1) 1,123,691,440 (2) 1,123,691, % 50%
21 Healthlink 2.0Healthlink Healthlink % % % % CMS % CMS024 CMS % %
22
23 Business Insights 22
24 CMS024 CMS024 CMS CMS CMS CMS CMS CMSERP 32 Treasure Sea Healthlink Healthlink Healthlink
25 99% Viewell Limited Great Creation Holdings Limited Archiever Development Limited Wide Harvest Limited Frost & Sullivan Frost & Sullivan (PTC)
26 eipo 55% 45% Healthlink Healthlink Consultancy Inc. Healthlink Healthlink 87.4% Healthlink
27 20,000,000 1% 0.004% 0.005% Treasure Sea IMS Health
28 180,000, ,000,00030,000,000 S144A A. 3. Computershare Investor Services (Jersey) Limited
29 Healthlink Healthlink 87.4% The London Stock Exchange plc
30 1% 0.004% 0.005% 20,000,000 10,000,000
31 144A 51% S S A A 144A 30,000,000 Treasure Sea
32 % Treasure Sea Treasure Sea 30,000,000
33 Treasure Sea Treasure Sea Limited UBS AG eipo eipo %
34 ADHF 9
35 CNS
36
37 GI
38 GAG 1 HBV B
39 Kaplan-Meier Lundbeck Takeda
40
41
42 rhbnp Henri Boulard 60 (AMD) T- T
43 a- BEL-7402 UDCA
44 90.9% 95.1% 96.2% 94.0%Lundbeck Export A/S Dr. Falk Pharma GmbH 79.0% 79.8% 77.4% 73.0% Synda LimitedSynda Limited24.5% Ophol Limited
45 84.1% 85.2% 82.3% 76.2% % 5.4% 5.0% 3.3%
46 % 79.6% 75.5% 70.2%
47
48 B % 54.2% 50.2% 45.9%
49 % 24.4% 22.9% 27.9% CMS024CMS024 Healthlink CMS024 CMS024Healthlink CMS024 IIb CMS CMS024
50 CMS024 CMS024 CMS024 CMS024 CMS024 2% 10%
51
52
53 %
54
55
56 8,500 1,240 90% ,50061%
57
58 5% 25%
59 2%1.2% 18.1% 11.5%
60
61 Healthlink2.0 Healthlink Healthlink Treasure Sea650,000, %
62 50%
63
64 %8.24 Treasure Sea 10% Treasure Sea 9.09 Treasure Sea
65 % 8.08 Treasure Sea Treasure Sea (x) (y) (z)
66 6 5(2)
67 S144A A
68 170,000,000 30,000, % 2.7% 871,632,124 11,123,800 60,000,000 30,000,000 60,000, ,755, %
69 (i) (ii)
70 2A-2B 5 B II C C Birney Avenue Vancouver BC V6S 0A4 Canada B 146 Maylands Drive Sidcup Kent DA14 4RL United Kingdom A
71 UBS AG 8 52 UBS AG 8 52 UBS AG
72 A Maples and Calder Hogan Lovells Hogan Lovells US LLP 875 Third Avenue New York, NY10022 USA A
73 Treasure Sea Limited c/o ATC Trustees (BVI) Limited 2/F, Abbott Building Road Town, Tortola British Virgin Islands
74 Maples Corporate Services Limited PO Box 309 Ugland House Grand Cayman, KY Cayman Islands 11 A H 21 H2 2A-2B 5 B
75 C
76
77 GMP
78 I IIIIIIV IV [2007]42
79 [2009]18 276
80 46 (i) (ii) (iii)
81 I(i) (ii) (iii)ii (i) (ii) (iii) I II
82
83
84 (2009) 25%
85 10% 50% 30% 3%
86 33% 25% 33% 10 50% 15% 24%33% 25% 15% 18% 20% 22% 24% 25%24% 25% 82 [2009] 25%
87 % 10 15% [2007]2 15% 95 50%150% 5% 7% 5%1% 10% 5%
88 25% 5% 25%10% [2009] 601 [2009] %
89
90
91
92 Frost & Sullivan 184,940 27, ,350 49, % 8.7% 14,144 2,08525,1253, %
93 10,4931,547 17,1752, % 3, , % % % ,947 22, % 6, , %
94 %... 6, , , , , , , , , , , , , , , , % 16.3%
95 90% % % 8,500 1,
96 65 3 Frost & Sullivan %1, %
97 Frost & Sullivan %1, % Frost & Sullivan
98 Business InsightsIMS Health 12.2% 10.6% 2,383 4,745 1,149 2,645 Business Insights IMS Health Frost & Sullivan % 78.8% %
99 Frost & Sullivan Frost & Sullivan 8311, % 16.0% 15.4%Frost & Sullivan IMS Health 5% 21.9% Frost & Sullivan 20.3%
100 8,500 1,2508,500 1, % 46.6% Frost & Sullivan
101 Frost & Sullivan % Frost & Sullivan %
102 Frost & Sullivan Frost & Sullivan Novamed 18% Novamed
103 CMS... 22% 22% 18% *... 7% 8% 17%... 8% 12% 10% Novamed... 2% 7% 10%... 6% 9% 7% Frost & Sullivan * 80%
104
105 FROST & SULLIVAN Frost & Sullivan Frost & Sullivan Frost & Sullivan60,000 Frost & SullivanFrost & Sullivan35 1,800 Frost & Sullivan Frost & Sullivan 30
106 Frost & Sullivan
107 99% Lundbeck Export A/S Dr. Falk Pharma GmbH Lundbeck Export A/S Dr. Falk Pharma GmbH 46.1% 95%2,880,000 90% 3,200,000 90%10% 90% 500,00010% 45,0005% 85% 5%
108 75% 10% 5% 5% 5% 83,570, ,000, ,000, ,000,000 3,000,000 10,000, ,0005% 9,000,000 90% 10% 83% 1,000,00090% 9,000,000 10% 1,000,000 10%
109 10% 1,000,00010% 2,480,000 8,280,000 24% 15,000,000 75% 42,150,000 20,000,000 25% 19,980,000 50,000 50, CMS International CMS International 10,000 10,000 1 CMS International CMS1 1 1 CMS CMS International 60% 3
110 ,407,828 40% Archiever Development Limited 263, ,000,000 55% 7,000,00049% 31% 20% 80% 55% 45%
111 ,000 10,000 1Winpro Development LimitedWinpro73.5% Synda Limited Pharma Stulln GmbH CMS Winpro Winpro 73.5%Winpro CMS 22,500, Winprod 18,000,000 4,500,000 CMS 15,000, ,000,000 3,000,000CMS 49.0% CMS Winpro73.5% CMS 73.5%CMS 24.5%36.7% Synda Limited38.8%
112 10 Pharma Stulln GmbH 10 Synda Limited 51% 5,865,000 51% 51% 4,905, ,000 5,635,000 49% 49% 60,000,000 (i)(ii) (iii)
113 49% 1,329,000 CMS HealthlinkHealthlink Healthlink 138 7,246, , Archiever Development Limited263, %
114 Healthlink Healthlink Healthlink Healthlink Healthlink % Healthlink HealthlinkHealthlink Healthlink Healthlink 95% 3 Healthlink 17.9% Healthlink HealthlinkHealthlink 5 (i)
115 (ii) 200
116
117 1. (a) 54,195, % (b) 4,930, % (c) 43,706, % (d) 5,276, % (e) 12 CMS 2,000,0000.2% (f) 14,825, % % 38.8% 4.
118
119 1. (a) 54,195,8204.8% (b) 4,930,0000.4% (c) 43,706, % (d) 5,276,6600.5% (e) 12 CMS 2,000,0000.2% (f) 14,825, % % 38.8% 4.
120 Frost & Sullivan 18% ,000 97% 86% 91.5% 34.6% 100,000 CNS 35,000 40, % 79.6% 75.5% 70.2% 90.9% 95.1% 96.2% 94.0% Frost & Sullivan 28.8% 47.6%
121 100% Dr. Falk Pharma GmbH Frost & Sullivan * *
122 Frost & Sullivan 21.9%5% 20.7% 1,107 Frost & Sullivan 38% Frost & Sullivan % Frost & Sullivan 46Frost & Sullivan UDCA 98.0% 55.9% (AMD) rhbnp
123 (AAD) 11.9% 16.3% 21.9% 22.9% 35.3% 25.4% 38.0% 32.4% 300 6,
124 % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,200 CMSH % 30.8% % 25.6% 64.9% 61.7% 63.1% 60.8%
125 55.0% 45.2%16.8% 20.7% 21.6% 25.1% 84.1% 85.2% 82.3% 76.2%
126 % 50.6% 46.1% 42.5% % 5.4% 5.0% 3.3% Frost & Sullivan % 86%
127 6, %34.6% 100,000 CNS Frost Sullivan 34.7% 20.9% Frost & Sullivan % Frost & Sullivan 46Frost & Sullivan 36.5% 55.0% 30.8% 45.2%
128 28.8% 47.6% 100% Dr. Falk Pharma GmbH %
129 36.5% 55.0% 16.8% 21.6% 30.8% 45.2%,25.1% 21.1% 34.4%28.8% 47.6% % CMSERP CMSERP
130 CMSERP CMSERP CMSERP CMSERP CMS024
131 1, CMSERP CMSERP CMSERP
132
133 % % % % %.. 47, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Frost & Sullivan CNS
134 ,000 97% 86% 40,000 35,000 *
135 (i) (ii)(iii)
136 70% 4, % 86%
137 % % % % ,113 3, ,076 4, ,525 5, ,525 5, , , ,192 1, ,192 1, ,151 1, ,608 2, ,780 2, ,780 2, ,917 1, ,286 1, ,553 1, ,553 2,
138 3,779 5,092 5,968 91% 34% 70% % 5 50% 10
139 CNS 28.8% 47.6% % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , ,
140 (1) H. Lundbeck A/S Dr. Falk Pharma GmbH Pharma Stulln GmbH (2) Bioniche Teoranta Dr. Falk Pharma GmbH Biocodex (1) (2)
141 % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , % 10% 30% Frost & Sullivan % Frost & Sullivan 11% % % % % % % % % % % % % % % 3 9.8% % 5 5.2% 5 6.5% 3 7.4% 4 7.5% % 4 6.9% 4 8.0% 4 7.1% 5 7.3% Frost & Sullivan
142 H. Lundbeck A/S 294, % % Frost & Sullivan (UDCA) 98.0% UDCA Frost & Sullivan %Frost & Sullivan 50% % % % % % % % % % % % 3 9.6% % % % % 4 2.0% 4 2.2% 4 2.3% 4 1.2% Frost & Sullivan Dr. Falk Pharma Dr. Falk Pharma 302, % %
143 (AMD) Frost & SullivanAMD % AMD 7.0% 8.3% 9.7% 46% Pharma Stulln GmbH 200 1,600 Pharma Stulln GmbH 600,000101,680,000 Frost & Sullivan (HBV)54 60 Frost Sullivan 360, ,000450,000 5
144 % % % 0.7% 1.0% , % %5.7 (GAG) IC/
145 PBS 100,00060 Bioniche Teoranta5 Bioniche Teoranta 550 1,0004,000 IMS Health 204 Datamonitor 20% ,271.4% %1.7 (AAD) Rev Infect Dis % 9.3%PubMed
146 5 (BSI) 1.6%3.1% CMS024 Budenofalk Dr. Falk Pharma GmbH Dr. Falk Pharma GmbH
147 Dr. Falk Pharma GmbH Dr. Falk Pharma GmbH CMS024( ) CMS024 CMS024 CMS024I IIa IIb CMS024IIbCMS024 Kaplan-Meier IIb CMS024 CMS024IIb CMS024 CMS024 CMS024 HealthlinkCMS024 Healthlink Healthlink CMS024 CMS024 CMS024 CMS CMS024 CMS024 CMS024 13% CMS024
148 1 6 2% 10% (i) (ii) 4560(iii)15
149 Dr. Falk Pharma GmbH Dr. Falk Pharma GmbH 96.8% 93.7% 90.1% 88.9% 67.9% 43.2% 47.5% 41.5% 5% 24 48
150 % 1.3% 1.0% 0.8% , , , ,000
151 CMSERP CMSERP
152 % 20.6% 21.1% 22.3% 5.6% 6.6% 6.2% 6.0%5% The China Fund, Inc. The China Fund, Inc. 5% 5%
153 9.1% 4.1% 2.7% 1.3% (i) (ii) 95% Healthlink HealthlinkHealthlink Healthlink % % % %... 4, , , , , , , ,955.85
154
155 T Sunpharma GmbH Sunpharma GmbHSunpharma GmbH
156 25,000Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Healthlink HealthlinkHealthlink Healthlink 17.9% Healthlink HealthlinkHealthlink Healthlink Healthlink CMS024 CMS024
157 3.1 CMS024 13%CMS024 CMS024 I IIa IIb CMS024 IIb CMS024 IIb CMS024 IIb CMS CMS024 CMS024 CMS024 CMS024 CMS024CMS024 CMS CMS024 CMS024 CMS024 13% % CMS024 CMS024Healthlink CMS024 CMS024 CMS024 CMS024 CMS024
158 CMS024 CMS024 CMS024 Healthlink Healthlink Frost & Sullivan Frost & Sullivan Frost & Sullivan UDCA98.0% 55.9%
159 1, ,265 70% 70% 459,000 2,700 50,000
160 55% 30,000 50, CMSERP
161 CMS024CMS024 CMS024I IIa IIb IIb CMS024 CMS CMS024 CMS024 CMS CMSERP CMSERP B. 35, ,
162 19,300, ,422.4 CMS ,451.14
163 (i) (ii) (iii) 37,060 45,060 37,060 26,000 50,000
164 (a) (b) Treasure Sea 57.8% Sunpharma GmbH 70% 9,000 16,000 41,000 44, ,000 Sunpharma GmbH 1690
165 16 90 Sunpharma GmbH70%Sunpharma GmbH 70% Pepharm R&D Limited Pepharm R&D Limited 70% 99%Sunpharma GmbH 30%Synda Limited Synda Limited Sunpharma GmbH 25,000Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH81, , , , , Sunpharma GmbH Sunpharma GmbHSunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH
166 Sunpharma GmbH107, ,000 9,000 16,000 41,000 44,000 Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH Sunpharma GmbH(i) (ii)sunpharma GmbH(iii) (iv) Sunpharma GmbHSunpharma GmbH Sunpharma GmbH Sunpharma GmbH 90%Sunpharma GmbH Sunpharma GmbH 18, , Sunpharma GmbH Sunpharma GmbH Treasure SeaHealthlink87.4% Healthlink Healthlink Healthlink HealthlinkCMS024 CMS024Healthlink
167 (1) CMS024 (2)CMS024 Healthlink Healthlink Healthlink Healthlink Healthlink HealthlinkHealthlink Healthlink Healthlink Healthlink Treasure Sea 10%
168 (i) 30% (ii) Treasure Sea Treasure Sea Treasure Sea 90.9% 95.9% 97.2% 98.7% 9.1% 4.1% 2.8% 1.3% CMS024
169 Sunpharma GmbH CMS Sunpharma GmbH Sunpharma GmbH CMS Sunpharma GmbH 107, ,000 Sunpharma GmbH 130,050 Sunpharma GmbH Pepharm R&D Limited70% Pepharm R&D Limited 70% 99%Sunpharma GmbH 0.1% 14A.33(3) CMS024 CMS024 CMS024 CMS024 CMS024 (i) 16 ZL (ii) ZL
170 CMS024CMS024 CMS ZL CMS024 13% CMS024 CMS CMS024 CMS CMS024 CMS024 CMS % CMS024 CMS024 14A Healthlink Healthlink Treasure Sea Healthlink 87.4% 14A.11(4) 14A
171 14A (i) (ii)(iii) (i) (ii)(iii) 0.5% 3% , , (i) (ii)
172 (2)(b) 1
173 CMS024 HealthlinkHealthlink HealthlinkCMS024 Healthlink Healthlink CMS024 CMS024 CMS024 CMS024 HealthlinkHealthlink Healthlink Healthlink
174 44 CMS 40 CMS 69 Jebsen & Company Ltd. 44 CMS Xinglong Enterprise (Shenzhen) Limited
175 47 20 Greater China Corporate Consultancy & Services Sanyo Securities (Asia) Limited Fidelity International Investment Management LimitedSassoon Securities Limited Northland Bancorp Seymour Pierce Reabourne Technology Investment Management Limited Close Brothers Asset Management Company China Medstar University College London Medical School Touche Ross & Co. Bylamson & Associates (Enterprises) Limited Kwan Wong Tan & Wong
176 XV C (2) CMS024 HealthlinkHealthlink Healthlink Healthlink CMS024 CMS024 CMS024 CMS024 HealthlinkHealthlink 38 CMS
177 513, , , , , , , , ,000
178 (i) (ii)(iii) (iv) 3A.19 3A.23 (a) (b) (c) (d)
179 100,000,000 20,000,000, ,691,440 4,768, % 170,000, , % 1,123,691,440 5,618, % 953,691,440 4,768, % 190,000, , % 14,173,900 70, % 1,157,865,340 5,789, %
180 ,173, , % 738,222 A % A. 5.
181 A. 3. (i) (ii)(iii) 20% (i) (ii) (iii) 0.5% 3%
182 (i) (ii) 451, , ,52811,
183 ,000,000 20,000,000,
184
185
186 1... 6,430 8, ,652 24, , ,786 23, ,006 5, ,287 4, ,195 6, ,594 3, ,239 32, ,233 9, ,226 8, ,085 1, ,079 2, ,193 54, ,751 4, ,999 7, ,152 3, ,769 2, ,484 5, ,015 22, ,056 10, ,539 26, ,604 19, ,053 11, ,308 90, ,668 66, ,940 43, ,419 45, ,975 29, ,450 25, ,630 53, ,999 34, ,254 32, ,367 2, ,792 62, ,645 63, , ,
187 Frost & Sullivan 18% ,000 97% 86% 91.5%34.6% 100,000 CNS 35,000 40,000
188 79.0% 79.6% 75.5% 70.2% 90.9% 95.1% 96.2% 94.0% Frost & Sullivan 28.8% 47.6% 100%CMS024 Dr. Falk Pharma GmbH Frost & Sullivan
189 * Frost & Sullivan 21.9%5% 20.7% 1,107 Frost & Sullivan 38% Frost & Sullivan % Frost & Sullivan 46Frost & Sullivan *
190 UDCA 98.0% 55.9% (AMD) rhbnp (AAD) 11.9% 16.3% 21.9% 22.9% 35.3% 25.4% 38.0% 32.4% 300 6, % 30.8% % 25.6% 64.9% 61.7% 63.1% 60.8%
191 55.0% 45.2%16.8% 20.7% 21.6% 25.1% (i) (ii) Healthlink Healthlink Healthlink 82.1% Healthlink17.9% Healthlink 1,969,0008,487, % Healthlink 38,921,747 Healthlink HealthlinkHealthlink 1
192 % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , % 79.6% 75.5% 70.2%
193 % % 11.9% 16.3% 21.9% 22.9%
194
195 16.2% 23.0% 22.6% 22.1% 25% 25%
196 92, ,000 10, , %
197 ,000 23,000 57,000 21,
198 ,500,0001,098, % 6.0 1,500,000219, % 5.0%
199 % % % % %... 47, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
200 Synda Limited Synda Limited Synda Limited10 Synda Limited 4% 6%Synda Limited 36.7%Synda LimitedSunpharma GmbH20% Sunpharma GmbHSynda Limited Synda Limited (i) (ii) 64.9% 61.7% 63.1% 60.8%
201 % % % % % (405) (0.4) (272) (0.6) (109) (0.2) (70) (0.1) (8) 2 7 (2) 6... (805) (0.8) , ,
202 % % % % %... 6, , , , , , , , , , , , , , , , , , , , , , , , , % % % % %... 2, , , , , , , , , , , , , , , ,
203 51% 3.051% 70, % 49.0%24.5% 55% 45% 55%
204 %, 23.0%, 22.6% 22.1% 25%... 15% (1) 18% 20% 20% 22%... 15% (1) 18% 20% 20% 22% (2)... 15% 15% 15% 15% 15%... 25% 25% 25% 15% (3) (1) 15% (2) 15% 15% (3) 15%
205 % % % % % ()... 51, , , , , (18,149 ) (35.1) (27,835) (38.3) (35,596 ) (36.9) (17,139) (36.6) (23,970 ) (39.2 )... 33, , , , , , , (13,934 ) (26.9) (18,631) (25.7) (24,840 ) (25.8) (11,366) (24.3) (13,318 ) (21.8 )... (2,773) (5.4) (1,221) (2.0 )... (5,947) (11.5) (6,940) (9.6) (7,399) (7.7) (3,908) (8.4) (3,274) (5.4 )... (1,633) (3.2) (2,275) (3.1) (2,038) (2.1) (1,057) (2.3)... (301) (0.6) (226) (0.3) (390) (0.4) (191) (0.4) (336 ) (0.5 ) (26) (0.1) , , , , , (1,672) (3.2) (4,487) (6.2) (6,096) (6.3) (3,243) (6.9) (4,355) (7.1 )... 8, , , , , , , (1) (5)... (145) (0.2) , , , , , , , , , , (11) (0.0) , , , , , , , , , , (22) (0.1) , , , , ,
206 % % % % %... 26, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , % % % % 16.9
207 77.3% 70.2% % % % % % % % 24.0% % % 1.3% % % %60.8%
208 % CMS % 13.3 (i) % 5.7 (ii) %4.7(iii) 24.3%2.5% 21.8% % 3.3(i) Healthlink 0.2 (ii)0.2 (iii) %3.0% 5.4% Healthlink HealthlinkHealthlink %
209 42,000 51% 24.5% 45,00026,000 19, % 42,000 25,000 21, % % 22% 25% 15% 23.5% 22.1% % % 25.1% % % % % % 6.1
210 % ,271.4% % % %2.8% % % %63.1% (i) (ii) % % (i) (ii) % 9.8 (iii) 25.7% 25.8%
211 6.96.6% %1.9% 7.7% % 2.0 Healthlink % % % , % % 20% 23.0% 22.6% % %21.6% % % 69.6
212 % % % % % %4.1% % 27.8 (i) (ii) % %61.7%(i) (ii) (a) (b) %2.7 Dr. Falk Pharma GmbH0.8 CMS % 18.6 (i) % 7.7 (ii) % 7.9 (iii) 26.9%1.2% 25.7%
213 % 6.9 (i) % 3.0 (ii) (iii) 11.5%1.9% 9.6% % 2.3 Healthlink % % % % %18% 5% 16.2%23.0% % %20.7%
214 ... 6,572 10,175 15,549 9,369 4, (1,861) (1,744) (16,616) (5,800) (2,812)... 3,072 (7,219) (4,022) (5,564) (6,937)... 7,783 1,212 (5,089) (1,995) (5,076)... 8,948 17,601 20,100 20,100 15, ,601 20,100 15,113 18,129 10, (a) 6.4 (b) 8.3 (c)
215 (a) 2.8 (b) (a)5.2 (b) (a) 7.5 (b) 5.0 (c)
216 (a)9.0 (b) 4.5 (c) % % % % % 0.860%100%
217 6.9 (i)4.7 (ii)1.4 (iii) 0.5(iv) 0.2 (v) 40% , Healthlink , ,246,
218 ... 10,677 5,945 11,060 17,437 15, ,305 27,684 32,794 41,485 43, ,060 17,641 17,792 13, ,601 20,100 15,113 10,340 7,639 47,767 55,004 77,120 88,308 81, ,920 9,252 11,062 12,235 6, ,517 16,346 12, ,226 1, ,100 10,755 29,788 31,371 20, ,667 44,249 47,332 56,937 61, ,486 5,795 10,806 17, ,677 5,945 11,060 17,437 (1) (1)
219 92, ,000 10, , (i) (ii) (i) (ii) %
220 ... 14,785 17,441 20,959 29, (307) (221) (213) (235)... 14,478 17,220 20,746 28, ,669 7,062 9,513 8, ,158 3,402 2,535 3, ,305 27,684 32,794 41,485 (1) (1) (i) (ii)
221 % 1.3% 1.0% 0.8% ,797 2,127 2,274 3, ,184 2,071 2,174 2, ,107 4,291 4,476 5, ,371 12,929 16,270 23, ,478 17,220 20,746 28, %
222 ,272 5,562 6,067 4, , ,401 5,593 6,079 4,307 (1) (1)
223 (1)... 16,517 16,346 12, ,179 5,291 4,986 5,020 (1) 12,548,000 13,533, , ,667, , % 15.8%
224 , , ,000
225 ,439 6, ,699 2,575 7, ,003 6, ,520 10, ,846 3,699 2,575 30,120 41
226 75.1% 70.1% 76.4% 81.7% 10.4
227 4.29 (1) (2) (3) ,789 73, , , , , (1) 64,954,000 6,165,000 (2) 170,000, (3) 1,123,691,440 25% 50%
228 Healthlink 2.0Healthlink Healthlink
229 7,457,000 (1) (2) ,123,691,
230 % % % % CMS % CMS024 CMS % %
231
232 UBS AG (a) (i)
233 (ii) (iii) (iv) (v) (vi) (vii) (viii) (ix) (x) (xi) (xii) Treasure Sea (xiii) (xiv)
234 (xv) (xvi) (1) (2) (3) (4) (b) (i) (ii) (iii) (iv)
235 (v) (vi) (vii) (viii) (ix) (A) (B) 10.07(1)(a) (a) (b) (a) (a) (2) 155
236 12 (a) (b) (A) (a) (b) (c) (a) (b) (d) (a) (b) (c) (a) (b) (c)
237 (a) (b) (c) (A) (B) (a) (i) Treasure Sea (ii) Treasure Sea (iii) (i) (ii) Treasure Sea (iv) (i) (ii) (iii) (i) (ii) (iii) Treasure Sea (b) (a)(i) (ii) (iii)
238 (c) (a)(i) (ii) (iii) (C) (a) (i) Viewell Limited Treasure Sea (ii) Viewell Limited (iii) (i) (ii) (iv) (i) (ii) (iii) (i) (ii) (iii)
239 (b) (a)(i) (ii) (iii) (D) (i) (ii) 30 20,000,000 10,000,00015%
240 3.5% Treasure Sea 3A.07
241 20,000, AS 180,000, ,000,000 30,000, A S
242
243 (a) (b) (c) (d) (a) (b)
244 20,000, ,000,00010% 1.8% 10,000,00010,000, ,000,000 50% (a)15 50 (b) (c)100 60,000,00080,000,000100,000,000 30%(a)40%(b)50%(c)
245 5.06 1% 0.004%0.005% ,000, ,000,000 30,000,000 90% 16.0% 144A S
246 30 20,000,000 10,000,000 15% 1.7% Treasure Sea30,000,000 15%
247 10.07(1)(a) 10.07(3) (a)(b) Treasure Sea Treasure Sea (a) (b) (c) (a) (b)(d) (e) (f) (b) (c) (d) (e)
248 30 Treasure Sea30,000,000 Treasure Sea 30,000,000 15%
249 1. (a)(b) eipowww.eipo.com.hk eipo (c) eipo 2. S eipo eipo eipo eipo S
250 3. S UBS AG
251 B 1A A-C A B A B G9B-11 (1) (2) (a)
252 (b) (c) (d) (e) (f) (g) (h) (i) (j) (k) (l) S S 902(h)(3) (m) (n)
253 (a) (i) (b) (i) (ii) (c) (i) (ii) (d) (i) (ii) 4. eipo (a) eipo eipo (b) eipo eipo (c) eipo eipo
254 (d) (e) (f) (g) (h) (i) (j) eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo
255 eipo eipowww.eipo.com.hk eipo eipo eipo eipo eipo eipowww.eipo.com.hk eipo eipo eipo 1,000,000 eipo
256 eipo eipowww.eipo.com.hk S S 902(h)(3) eipo eipo eipo eipo eipo (a) (b) eipowww.eipo.com.hk (c) (d) (e)
257 (f) eipowww.eipo.com.hk (g) (h) (i) (j) (k) S S 902(h)(3) (l) (m) eipo eipo (n) eipo eipo eipo eipoeipo
258 ( (a) (b)
259 40 342E
260
261 E (a) (b) 6.
262 eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo eipo
263 eipo eipo10,000,000 50% eipo eipo eipo % 0.004% 0.005% 800 4,
264 8. (1) (1) (1) (1) (1) (1) 24 eipo 4. eipo 9. 8
265 A % 0.004%0.005%
266 1% 0.004%0.005% 1% 0.004%0.005% 12. eipoeipo eipo E eipo
267 eipo eipo eipo eipoeipo eipo 50% 10,000,000
268 13. (a) eipo(i) (ii) (b) (i) (ii) (iii) 1% 0.004%0.005%
269 eipo (a) 1,000, ,000,000 1,000,000 (b)
270 1,000,000 1,000,000 1,000,000 (c) eipo eipo eipo 1,000, eipo 1,000,000 eipo eipo eipo eipo
271 (d) 1% 0.004% 0.005%
272 15.
273 London Stock Exchange plc CMS 10, % 100% 100% 100% 100% CMS 1 CMS Peptides Patent Holding % 70% Company Limited 2 CMS Peptides Healthlink Consultancy Inc. 474, % 100% Healthlink 2 100% 100% 100% 100% 100% 20,000,000 70% 70% 3,660,
274 100% 100% 100% 100% 100% 10,000, % 100% 100% 100% 100% 21,288, % 100% 1,300, % 100% 100% 100% 100% 150,000, % 100% 10,609, % 100% 100% 100% 100% 10 60% 60% 60% 100% 100% Crosspac Group Limited 10 70% 70% Crosspac % 100% 100% 100% 2,000,000 CMS 1 100% 100% 100% 100% CMS 1. CMS 2. Healthlink CMS Peptides CrosspacHealthlink (b)
275
276
277 A ,747 72,600 96,454 46,775 61, (18,149) (27,835) (35,596) (17,139) (23,970)... 33,598 44,765 60,858 29,636 37, ,280 2, (13,934) (18,631) (24,840) (11,366) (13,318)... (2,773) (1,221)... (5,947) (6,940) (7,399) (3,908) (3,274)... (1,633) (2,275) (2,038) (1,057)... 7 (301) (226) (390) (191) (336) (26) ,346 19,535 26,926 13,800 19, (1,672) (4,487) (6,096) (3,243) (4,355) ,674 15,048 20,830 10,557 15, ,639 2, (1) (5)... (145) ,313 17,964 20,754 10,576 15, ,685 14,946 20,684 10,448 15, (11) ,674 15,048 20,830 10,557 15, ,335 17,877 20,608 10,467 15, (22) ,313 17,964 20,754 10,576 15,
278 ,940 5,459 3,575 3, , ,507 1, ,575 6,461 5, ,073 1,432 1,153 7,177 15,490 13,657 15, ,677 5,945 11,060 17, ,305 27,684 32,794 41, ,060 17,641 17, ,601 20,100 15,113 10,340 47,767 55,004 77,120 88, ,920 9,252 11,062 12, ,517 16, ,226 1,848 13,100 10,755 29,788 31, ,667 44,249 47,332 56, ,844 59,739 60,989 72, ,725 4,725 4,741 4, ,275 48,065 48,992 60, ,000 52,790 53,733 64, (156) (69) ,844 52,721 53,934 64, ,764 2, ,179 5,291 4,986 7,018 7,055 7,275 41,844 59,739 60,989 72,229
279 ,363 13,589 18,469 14, ,365 13,623 18,482 14, , ,267 13,436 18,340 14, ,287 13,456 18,350 14, ,725 4,725 4,741 4, ,562 8,731 13,609 9,736 21,287 13,456 18,350 14,504
280 ,909 2, ,080 (46) 13,223 (138) 13, ,650 1,650 (11) 1, ,685 8,685 (11) 8, ,650 8,685 10,335 (22) 10, ,998 (3,998) ,264 19,989 19, (570) (1,547) (1,547) (1,547) (4,725) 4, ,822 (845) (977)... 4,725 17,147 4, ,255 2,730 2,937 4,725 42,000 (156) 41,844
281 ,725 17,147 4, ,255 2,730 2,937 4,725 42,000 (156) 41, ,895 2,895 (15) 2, ,946 14, , ,931 14,946 17, , (2,362) (4,725) (7,087) (7,087)... (4,725) 4, ,802 (1,802)... 4,725 17,147 4, ,057 5,661 8,994 4,725 52,790 (69) 52,721
282 ,725 17,147 4, ,057 5,661 8,994 4,725 52,790 (69) 52, (1) (1) (1)... (145) (145) (145)... 20,684 20, , (145) 20,684 20, , (8)... (36) (206) (206)... (11,503) 853 (10,650) 330 (10,320)... (4,741) (4,725) (9,466) (9,466)... (4,741) 4, ,102 (2,102)... 4,741 6,079 4, ,159 6,555 (145) 18,122 4,741 53, ,
283 ,725 17,147 4, ,057 5,661 8,994 4,725 52,790 (69) 52, ,448 10, , ,448 10, , (4,725) (4,725) (103) (4,828) (4,725) 4, ,339 (1,339) 4,725 17,147 4, ,396 5,680 13,378 4,725 58,532 (63) 58,469
284 ,741 6,079 4, ,159 6,555 (145) 18,122 4,741 53, , (5) (5) (5) ,230 15, , ,230 15, , ,299 2,325 2, (2,221) (2,221) (104) (2,325)... (201) (201)... (4,741) (4,741) (4,741)... 1,068 (1,068)... 4,768 8,481 2, ,227 7,047 (113) 32,284 64,954 64,954
285 ... 10,346 19,535 26,926 13,800 19, (56) (152) (30) 26 (42)... (43) (21) (25)... (647) (647) , (236) (221) (329) (94) (302)... (30) (20) ,773 1, (2) (7) 2 (6) (24) ,944 21,080 29,198 14,331 21, (8,986) 5,347 (5,226) (2,840) (6,432)... (4,545) (7,526) (5,287) (2,976) (8,255)... (31) (375)... (56) (8) (481) (25). 624 (23) 43 (18)... 7,734 (5,011) 2,284 3,174 1, (6)... 8,709 13,859 20,672 11,674 7, (2,111) (3,637) (5,008) (2,300) (3,254)... (26) (47) (115) (5) (6)... 6,572 10,175 15,549 9,369 4,673
286 ... (795) (959) (280) (59) (101)... (2,919) (a) (770)... (149) (537)... (1,060) (16,581) (5,069) (151) (b) (1) (877) (877)... (1,861) (1,744) (16,616) (5,800) (2,812)... (7,082) (9,471) (4,730) (4,741)... 39(a) (10,068)... (137) (1,245) (731) (512)... 19, ,757 16,517 2, (4,320)... (1,416)... (12,905) (2,726)... (5,148)... (301)... (206) (103) (201)... 3,072 (7,219) (4,022) (5,564) (6,937)... 7,783 1,212 (5,089) (1,995) (5,076)... 8,948 17,601 20,100 20,100 15, , ,601 20,100 15,113 18,129 10,340
287 1. London Stock Exchange plc Treasure Sea Limited PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman IslandsA 8 CMS VI ,221, IFRIC* 14 4 IFRIC19 3 * IFRIC 1
288
289
290
291
292
293
294
295
296
297
298
299 4. 610,000 7,575,000 6,461,000 5,786, ,000 1,073,000 1,432,000 1,153, , , , , ,478,000 17,220,000 20,746,000 28,931, , , , ,000
300 , ,000 1,334,000 3, ,0002,022,000 8 (1) (2)
301 ... 47,013 4,734 51, ,841 (3,841)... 47,013 8,575 (3,841) 51, ,260 4,338 33, , (13,934)... (2,773)... (5,947)... (1,633)... (301) , ,595 3,005 72, ,496 (4,496)... 69,595 7,501 (4,496) 72, ,237 2,528 44, , (18,631)... (6,940)... (2,275)... (226) ,535
302 ... 93,752 2,702 96, ,100 (2,100)... 93,752 4,802 (2,100) 96, ,419 2,439 60, (24,840)... (7,399)... (2,038)... (390) , ,188 1,587 46, (484)... 45,188 2,071 (484) 46, ,184 1,452 29, (11,366)... (3,908)... (1,057)... (191)... (26) ,800
303 ... 60, , (430)... 60,389 1,236 (430) 61, , , (13,318)... (1,221)... (3,274)... (336) ,689 3
304 , , , ,
305 ... 26,144 36,710 44,468 22,768 26, ,756 21,074 28,327 13,393 16, ,011 4,394 6,146 2,817 3, ,599 3,910 4,780 2,243 2, ,839 7,253 2,983 5, , , , ,237 3,474 3,141 1,742 1, ,747 72,600 96,454 46,775 61, (405) (272) (109) (70) (8) 2 7 (2) (805) ,280 2,
306
307
308 Paul Bernard Harper Stuart Hamilton Leckie
309 ,000,
310 ,864 4,236 5,443 2,725 3, ,885 4,305 5,546 2,725 3, (6) (21) (11) (7) (11) (169) (38) (207) ,672 4,487 6,096 3,243 4,355 33% 30% 3% 63 15% 25%
311 15% 18% 20% 20% 22% 15% 15% 15% 15% Labuan Offshore Business Activity Tax Act 1990Labuan CMS 20,0006,000 3% CMS 17.5% 16.5% 17.5% 16.5% 16.5% 16.5% 16.5%
312 ... 10,346 19,535 26,926 13,800 19, ,552 3,516 5,385 2,760 4, (9) (4) (6)... (8) (27) (6) 5 (9) (337) (122) (52) (1) (17) (177) (78) (28) (4) (198) (265) (280) (131) (13) Labuan... (133) (629) (260) (627)... (6) (21) (11) (7) (11)... (169) (3) (2)... (38) (2) ,672 4,487 6,096 3,243 4,355 15% 18% 20% 20% 22%
313 ,633 10,668 13,082 5,658 5, ) ,675 11,827 14,723 6,199 6, )... 2,773 1, , ,413 25,753 34,078 16,349 23, London Stock Exchange plc
314 ,362 4, ,307 4,725 4,725 4, ,418 7,087 9,466 4,725 4, ,307 4,725 4, , ,725 4,725 4,725 4,741 4, ,362,000 4,741,000 4,725, ,725,000 4,725,000 4,741, Healthlink 39(a)... 8, ,969 10,650
315 ,685 14,946 20,684 10,448 15, ,647, ,927, ,290, ,927, ,963, ,965 5,132,705 10,643, ,186, ,927, ,422, ,927, ,607, ,980,000
316 , , , (568)... (18) (16) (17) (51)... 2, ,223 1,228 1,055 8, (108) (32) (140)... 2, ,562 1,836 1,334 9, (32) (409) (24) (465)... (12) (12)... (926) (57) (983)... 2, ,716 1,556 1,287 8, (31) (1) (32)... 2, ,731 1,585 1,343 8,512
317 , (18) (7) (13) (38) , , (97) (29) (126)... 1, , , (30) (305) (17) (352)... (6) (6)... (600) (37) (637) , , , (26) (1) (27)... 1, , , , , , , ,987 1, , , , , , , %
318 4.75% 18% 18% 18% , , ,
319 % 55% 55% (459) (518) (704) (731)... (26) (42)
320 , (14) (14) ,687 1, (52) 157 (180) (189) ,507 1,498 51% 51% % 24.49%
321 (1) 51% 411,235,000 1,765, , ,000 70,000 (2) 22,500,0003,295, %18,000,000 2,636,000 4,500,000659, % 7,500,0001,098, % 38.78% 36.73% 7,500,0001,098, %6,000, ,000 1,500,000219, % 647, , , (65) (161) (1) ,050 6,154 6, ,507 1,498
322 ... 1,084 1,654 2, (9) (3) (23) (26) (1) (5) % 5,865,000770,000 2,550,000335, ,000126,000 1,329,000187,000 51% 20(b)
323 20. a b a(i) a(ii) ,775 7, (717) 628 (89) ,403 8, ,403 8, a(iii)... (258) (258) ,403 8, (59) (59)... (2) (2)... (61) (61)... (14) (14)... (302) (491) (793) (288) (491) (779)... (294) (821) (1,115)... (582) (1,312) (1,894)... (3) (3)... (49) (370) (419)... (634) (1,682) (2,316) ,912 7, ,091 6, ,721 5,786
324 (a) (i) , , , (b) 628,000 (b) (ii) Lyophilized Recombinant Human Brain Natriuretic Peptide Nesiritide Nesiritide Nesiritide Nesiritide 2,000 Nesiritide 2,000 Nesiritide2,000 2,0006,500, ,000 Nesiritide Nesiritide 919,000 3 (iii) 2,000 1,755,000258,000
325 (b) Pharma Stulln GmbHPharma 1951% 60,000,000 8,779,000 CMS Pharma CMS 6,000,000878, ,775, % 878,000 CMSPharma (202) , ,000
326 10% 20% 15% 15% (839) (17) (203) ,073 (839) (925) 120 (561)... (5) (5)... 1,312 (1,764) 120 (332) 9... (268) (525) (12) (805) ,045 (2,289) 108 (1,136) 14
327 ,073 1,432 1, (839) (1,764) (2,289) (332) (1,136) 4,310,000 6,659,000 2,178,000 2,294,000 3,804,000 5,859,000 1,378,000 1,439,000 16,772,000 35,280,000 45,766, ,486 5,795 10,806 17,305 10,677 5,945 11,060 17,437
328 ,785 17,441 20,959 29, (307) (221) (213) (235) 14,478 17,220 20,746 28, ,669 7,062 9,513 8, ,158 3,402 2,535 3, ,305 27,684 32,794 41, ,164 14,811 17,879 25, ,188 2,316 2,839 3, ,478 17,220 20,746 28,931 4,107,000 4,291,000 4,476,000 5,929,000
329 ,797 2,127 2,274 3, ,184 2,071 2,174 2, ,107 4,291 4,476 5, (127) (65) , , , , (a)
330 (b) 312, ,000 (a) (b) % 5.00% 0.36% 5.00% 0.36% 1.71% 0.50% 2.25% 1,060,000 17,380,000 17,456, , ,000
331 ,272 5,562 6,067 4, , ,401 5,593 6,079 4, ,049 1,564 2,239 2, , ,030 1,634 1,818 4,262 12,920 9,252 11,062 12, ,557 5, ,960 10,440 16,517 16, ,517 16, %
332 17,380,000 17,456, ,179 5,291 4, ,864 6,129 5,797 60,000,000 8,779,000 20(b) 6,000, ,000 5% 6,775,000 6,864,000 5,966,000 5,633,000 18(2) (18)
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