...1... 11...14...22...25...30...34...36...37 -...43...47...49...62...65 WTO...72...80...86...90...94 I
...99... 102... 103... 113... 114... 115... 120... 133... 138... 141... 145... 147... 153... 158... 166... 172... 186... 196... 197... 198 II
IGG ( ) 400 100 1000 1
( ) 2
/J ( ) 1 I IGA 3
A IGA I 2 4
IGG 25% 95% PH NH4 5
( B ) IGF I (Mero 1997) 6
IGF L 39 ( 18 35 ) 8 ( 3 45min) 60G (23 Vo (53.5 1.1)mL/(Kemin)) C16 VA(54.2 1.7)mL/(KSmin))o 4 8 (10Km/H 3min 1%) 20min 4 2 (P>0.20) 4 8 8 [ (4662 25(1)m (4237 32(3)m 0.0(4) [ (150.7 17.1)KI (124.2 18.9)KJ p=0.0(3) TEM 2% 7
IGF I IGF I IGF I IGF-I IGF-I ( ) JyvASKyLA AN'ITLMERO (1997 ) IGF I 9 3 8D 13D 25 125mL ( ) ( ) 25 125mL ( 125mL ) IGF (P<0.0(5) 8D IGF-I 0.68 0.69 P=0.038 0.045 IGF-I 8
8D IGF I ( <0.0(5) 125mL IGF-I D [(0.54 0.26)moL/L P<0.0(5) 0.54nmoL/L IGF-I 3.7% 25mL 125mL IGF-I 3.48% 4.13% 8.0% 125mL IGF-I 20D IGF I 10.8nmoL/L IGF-I IGF-I IGF I IGF I 125I IGF-I IGF- 8D IGF-I 9
IGF-I IGF- IC F-I -B(TGF-B) IGG IGA TGF-B IG IGA (FGF) (1GF-(1) (EGF) 10
F.Y.BHORA (1995) FGF IGF-I EGF 1 2 ( ) 11
307 312 7 7 60 65 10 5000KG 10000KG 30KG 18929KG 2.0% 2 3 12
32.7KG 41.7KG (HoLStein) 24KG 54K8 4 39 52KG 6 12H 3.6KG( 10.4%) 3 6.8 11.7KS 14% 35% 43.5KG 3 11KG 3 32.5KG 4 1.8 3.2KG ( ) 2.5KG 1 1 16 13
4 5 420 200000 20 70 14
6H IGG 65.8% 12 24 36 48H IGG 46.9% 11.5% 6.7% 6.0% 1 2D 24 36H 20 70 DAviD TyrreL 15
( ) 1 ALBert SABin 20 50-16
( 40mL) S.KuHL (1978) RouSe (1976) 1980 WortHwicK PArK DAviD TyrreLL LGA IGG IGA 17
R.H. MicHAeLS EcHo CoxSAcKie E.1PALmer 2 0157 H7 O111 NM 1995 HurLey 18
10% 20mL 3 A B AcoStA ALtAmirAno (1987) (AmoeBA ) WALtz (1993) HIV ( ) 19
CrAGo MeStecHy(1983) B T Guto (1985) 20
(PRP) PRP ( ) 4 0.45KG 20% ( ) 21
20 90 21 20 80 22
VySHemirSKii F.A ABroSimovA S V. 1990 18% 29% 70 75 10 15min 1990 1989 23
1991 7 1995 9 (FAO) (WHO) (1LSL) 1997 1 28 ( ) (GBL6740 1997) ( ) ( ) 24
(PRP) (1GF-I n) (TGFA) (EGF) 1799 HuFeLAnD 19 1955 ( ) 25
ArurveDic RiSHiS KHArwAS RiSHiS 26
FDA 20 90 ZAwiStowSKi MAcKinnonR. 1993 400 360 320 LGG 1.0 1.5MG/mL 38 1.5 2.0MG/mL 2 2.0MG/mL IGG 1.0MG/mL 20 40 60 70 27
20 70 ( / ) 1987 SterLinGTecHnoLoGy 1958 Immuno Dy namics.inc 20 70 MicHAeL KLAGSBrun 1980 1995 28
120 200 KLAGSHmn LeHtoE. InternAtionAL FooD InGreDientS 10 New LiFe 29
B C E 1 72 7 8 110 2002 560 16 30 30
16 2 A 2 72 B C 31
D 3 IGG IGG IGG IGG 32
IGG IGG 4 33
1 0 6 2 34
3 35
1 (CPP) 2 50 36
( 50 ) 30. YNET 37
38
39
22 22 40
41
84 42
- 43
1988 ( ) 10 7 1988 8 1990 1993 1994 12 44
1992 1994 3 24 1995 6 6 ( ) 14 1999 1 21 45
2000 6 9 46
72 45% 12% 19 ( ) 47
0.2 10 1 3 10 2 4 0.5 6 30 1 (1 ) 1 2 (1 ) 50 (IG) IG FC IG IGG IGG FC IGG (ADCC) IGG IGG 48
C3B IGM 2001 76 62.6% ( ) 37.4% ( ) 8 1 7 31 2001 2002 20500 49
(SeLF-SuFFiciency) 70 50
1965 1413 2001 292 219 56 ( ) 1975 1988 1995 25.8% 51
( 60%) 52
( ) ( ) 60% 70% (MiLK MArKetinG B0ArD) 1999 53
66% 40 24 1990 46% 99 66% AGropur 1997 2000 AGropur LActeL 2000 DAiryworLD 8 54
55
(CAnADiAn FooDInSpection AGency) ( ) 56
57
40 7 15 1.5 58
59
12 60
1/3 ( ) 61
22 80% 250 80% 300 50% 60% 3 62
75% 60% 50% ADFF DAPF MMFA ADIC ADC 6 ADPF MMFA 63
2000 1 2000 6 30 ADC ADC 2-10 64
1560 101.2 82.2 5890 124561 / 112975 109075 204258 ( ) B 65
( ) PH 1 2 1 (1) 66
( ) 1 2 0 5 2 (2) 100 300 120 15 30 25 30 ( 1%) 2 3 (3) 67
1% 2% 90 30 60 25 ( 1%) 2 (1) (2) 90 110 ( T) (3) 109 / (4) 3% (37.8 ) 3.5 ( ) T 0.009 68
0.4% 3 ( ) (1) (2) ( ) 80 30 HTST UHT 2% 3% ( ) 0.1% 0.2% 0.5% 1% 37 6 8 40 42 3 4 0.7% 0.8% 20 69
1.3% 1.4% 8 13 10% 20% ( ) 3 11.5% 3.0% 120 T 100 90 11% 3% 1 2 70
( 50 T) 3 4 ( ) 1 3.0% 3% 71
2 ( ) 5 6 (1) 90 20 30 40 1% 3% 1 2 2.0% 90 1 1.5 20 1.0% 1.3% (2) 10 1% WTO WTO 72
WTO 21 1 1949 1989 21.7 418.9 40 18.3 1990 1999 475.1 806.9 9 69.8% 1995 52.6 2000 82.9 5 57.6% 1996 51.9 2000 150 4 189% (1) 1999 5.64 97 7 1/14 (2) 73
(3) 2 1992 1998 446.4 675.2 (1) 30% 90% 1992 9 1998 19 (2) 3 7 97 300 74
40 WEI ANNING(1999) 1990 1993 0.4 1993 1995 0.81 1994 1995 1.13 10 1350 2030 25 4250 75
1 1992 6154 1998 8468 8.6% 0.3% 0.4% (1) 1996 1998 76
52% 1996 1998 50% (2) 2 WTO 2004 25% 12% 19% 15% 10% 10% 15% 18500 21000 / 16000 / 4 77
1 2 20 60 70 80 90 21 78
3 WTO 79
ß ( KLUVEROMYCES MARXIANUSVAR.LACTIS.) ß D a D ß D FDA JACFA 3.2.1.23 GB2760 PH6.6 6.8 35 40 2 4 80
( ) ( ) ( ) 20 7 8 81
75% 100% 5% 30% 90% 100% 12% 70% 30 Z0% 88.9% 55.1% 1998 1168 3 13 25 87% 82
30% 80% 6% 12 25 12 ( 4.8% 250 ) 20% 30% 83
400 9000FCC 51.1% 75% ( 2 4 / ) 84
80% 35% 85
( ) a D ß D a D ß D 4.8% 86
a D ß D 60% 8% 20% ( ) ( ) 2 ( ) 87
PH a ( ) 88
( 4 ) 35 (20% 25%) 5% 10% 40% 60% PH 89
90
100 6.6 20 100 ( ) 25% 75% 50% 200 80% 25 91
10 30 WTO 92
1 62 65 30 2 72 75 15 3 130 150 0.5 4 4 115 120 15 20 ESL 93
50% 3 10 WTO ( ) 94
1/3 50 2 3 95
( ) 1/3 1/2 50 60 ( ) ( ) ( ) 15 20KG 80 120 96
Lmin 80 90 /min 120 min 80 90 /min 1 2.0KG 6 7 ( ) 97
1 6 10min 12% 2 3 98
4 5 ( ) 1 2 1 10 0.3% 0.5% ( ) 99
3 4 50 0.5% 10 20 ( ) 1 4 3 1 2 ( 100
) 3 ( ) 3A 50.8 16.6 18 1.6 ( ) 1 2 101
3 4 5 1.5% 2.5% 5% 1000 1500 40% 60% ( ) 1.5% 3.8 102
2.5% 50% 50% 0.8% 2.1 21.. ( 103
) 1 FDA(1989 ) 40 30 1994 2 (LAB LActic AciD BActeriA) ( ) 18 (LActoBAciLLuS) 104
(BiFiDoBActerium) (StreptococcuS) (LeuconoStoc) (EnterococcuS) LActococcuS) (CArnoBActerium) (AtopoBium) (PeDiococcuS) (AerococcuS) (VAGococcuS) (LiSteriA) (SporoLActoBAciLuS) (BAciLLuS) (BrocHotHrix) (ErySipeLotHrix) (GemeLLA) (SAccHArococcuS) ( 1996) ( ) 3 BAirD(1977) 105
LiDBecK (1992) (1993) 7 7.67% 6 5.4% 5 7.32% 5 9.5 ( ) 13.2% 6.3% 27.7% GALLAGHer (1974) (1) (2) (3) 3.1 ( ) ( B K H ) 106
HAmAD(1979) (1988) 72% 85% 40% 46% (VB) (V) 1.6 1.4 1.3.9 1.5 1.2 PH ( 6.5. 4.4) 3.2 (1) (2) (3) 107
3.3 ( 108
) IGA IGM IGG T B ScHiFFrin (1994) (L.JoHnSonnii)LJ1 (B.LActiS)B IGA GiLL(1998) 1985 1995 OuweHAnD (1999) ( ) (M CeLL) M CeLL 4-4.1 109
FuLLer(1989) OuweHAnD (1999) (1) (2) (3) (4) 110
(5) 4.2 (1) (2) (Fe Cu Zn Se Mo ) (ArG Tyr Pro PHe ) B ( 1996) (3) (KAiLASApAtHy 111
2000) (4) 5 ADAmS (1999) Dunne (1999) 112
0.5 1 ( ) 113
70 80 114
(UHT) UHT (6 30 ) 115
18 1 (LActic AciDBActeriA) (BiFiDoBAeterium) 116
(ExtenteDSHeFF LiFe) ESL UHT 7 35 ESL 2 Zn ++ AG + ( FDA ) Zn ++ AG + ( ) Zn ++ AG + SH 3 117
+ ( ) ( ) ( ) 2% 80 3 ( 25%) 4 24 ( ) 5 118
A B 45% 85 90 65 25MPA 25 110 T C 1 6 3 3 5 5 12 13 119
W=C+V+M W C V M C+V C+V 120
4 1 121
( ) 54.60% 8.09% 4.12% 9.42% 23.72% 2.08 45 60% 2 4.44% 55 59% 21 46.78% 50 54 17 37.78% 50% 5 122
11.11% 41.57% 3 85% 90% 26 8.47 18.51 3.87 1 3 1 2.27 20 4 15% 1.96 1.3 0.22 0.12 0.72 0.48 123
45 8.09% 8% 11 24.44% 10% 5 11.11% 7.02 8.72 24.2% 8 4.16 7% 45 13.54% 8 124
13% 22.57% 85% 1997 1998 125
30% 55% 1 3 1 2.27 30% 4% 3.36% 126
40 NRC 6 11 12 3 6 6 12 11 6 24 127
40 128
40 15 129
( ) 550 18 3.4% 7 30% 15% 55% 22 4 1 2 15% 85% 15% 1 1 1 1 1 1 1 1 130
131
132
80% 1 1.1 10 30 30 133
200 200 500 500 64 ( ) 1.2 1.3 2 134
1 3 15% 210 68% 26% 135
1991 1 2 18% 4% 800 4 136
5 6 137
4000 5000 6000 7000 50KPA 138
(ORION) 50 40 42KPA 50KPA 60KPA 50KPA ( ) 40KPA 139
1996 1 1 30% 6% 2 33% 3 (60KPA) 80% 140
141
? 142
143
144
CS 20 CSI( ) 80% 145
CS CSI 5W1H (5 1 ) 1?( ) 2?( ) 3?( ) 4?( ) 5?( ) 146
147
2 148
( ) ( ) ( ) ( ) 149
( ) ( ) 150
1 ( ) ( ( ) ( ) ( ) 2 151
3 ( ) ( ) ( ) 152
153
(1) (2) (3) (4) (5) (6) (7) 154
50% 9 00 11 00 7 00 8 30 155
(1) (2) ] 156
(3) ( ) (4) 157
(4) 2003 158
2002 1250 26% 66% 2002 9.7 107 300 2002 60 46 6 2002 13.6 1.2 159
60 160
( ) 161
1997 D 162
1999 2002 50 163
50% 3% 4% 150 AA+DHA 164
165
3 19 8 2556 6 50 166
( ) (1) ( 167
) ( ) (UHT) ( ) UHT 6 168
( ) OEM 169
(2) 12 170
171
( ) 2001 172
( ) 173
( ) 174
P&G P&G P&G 175
176
( ) 177
178
POP 15 ( ) 179
( ) ( ) 180
181
( ) 182
2001 183
1 2 3 4 5 184
( ) 185
( ) 186
( ) ( ) 187
188
( ) 189
( ) ( ) 190
1 2 3 4 5 191
192
2001 ( ) ( ) 193
194
195
? 800 200 90 196
20 900 160 197
UHT (UHT) 135 150 1989 50 UHT 198
135 152 62 75 97.3% 99.9% 4 8 6 9 7 15 16 4 7 199
200
201