Pa Shun Pharmaceutical International Holdings Limited (a) (b) (c) (d) (e) (f) (g) (h) (i) 1933 (j) (k)
Pa Shun Pharmaceutical International Holdings Limited [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ][ ] 1% 0.0027% 0.005% 0.001 [ ] [ ] [ ] 32 342C [ ] [ ][ ] [ ] [ ][ ] [ ][] [ ][] [ ] [ ] [ ][] 1%0.0027%0.005%[ ] [ ] [][][][] [ ][ ][][ ] [ ] [ ] www.hkexnews.hk [ ][ ] [ ][ ] [ ] [ ] 8 [ ] [ ] S [ ]
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(i)(ii) (i)(ii) (iii) 20131231 2013 2014 12 3127 2011 20122013 40% 2011 2012 2013 0.06%0.05% 0.05% 1
(i) (ii) (iii) (iv)(v) (vi) (i)(ii) (iii) (iv)(v) 2
(i)(ii) (i) (ii)v-drug[ ] V-drugV-drug Chubu Yakuhin Co., Ltd 30 90 [ ] [ ] [ ] [ ] 2012 2 [ ] AB A B[ ] [][][] 3
12 31 2012 2013 2014........................ 712,111 794,349 847,193...................... (582,575) (643,924) (665,126).......................... 129,536 150,425 182,067...................... 10,379 14,612 20,672.......... 354 33 (710)............... (33,380) (35,990) (36,468)............... (25,137) (25,779) (46,729)...................... 81,752 103,301 118,832...................... (3,453) (5,855) (9,013)...................... (4,714)................. (51,881) (16,134) (33,236).................... 26,418 81,312 71,869........................ (17,110) (18,243) (25,740)...................... 9,308 63,069 46,129........... 9,409 63,070 45,944................. (101) (1) 185 (1)........................ 0.013 0.090 0.065 (1)........................ 0.013 0.079 0.065 (2).............. 61,189 79,203 79,365 4
(1) (2) 12 31 2012 2013 2014.................... 72,998 154,420 138,811...................... 432,646 532,769 575,181...................... 370,055 484,500 468,601................. 62,591 48,269 106,580............. 135,589 202,689 245,391...................... 72,615 141,080 181,280 12 31 2012 2013 2014.................... (42,242) 92,225 48,664....... (2,698) (105,599) (16,294). 34,067 39,935 (30,933).................... (10,873) 26,561 1,437......... 50,120 39,227 65,375............... (20) (413) 247......... 39,227 65,375 67,059 5
12 31 2012 2013 2014........................ 18.2% 18.9% 21.5%........................ 1.3% 7.9% 5.4%...................... 1.2 1.1 1.2...................... 1.0 1.0 1.1...................... 13.1% 45.0% 25.5%.................... 1.8% 9.2% 6.5%................. 33.1% 53.2% 27.6%............... 6.8%............... 8.7 14.9 9.0 12 31 2012 2013 2014............. 624,525 74,147 11.9% 695,860 89,755 12.9% 707,053 98,595 13.9%......... 7,831 3,092 39.5% 17,626 5,621 31.9% 29,352 9,827 33.5%.................. 79,755 52,297 65.6% 80,863 55,049 68.1% 110,788 73,645 66.5%................ 712,111 129,536 794,349 150,425 847,193 182,067 6
12 31 2012 2013 2014.............. 630,165 61,617 9.8% 703,245 79,918 11.4% 713,577 90,260 12.6%......... 7,831 2,764 35.3% 17,626 5,415 30.7% 29,352 9,504 32.4%.................. 110,036 68,717 62.4% 105,374 66,485 63.1% 132,924 82,624 62.2%................ 748,032 133,098 826,245 151,818 875,853 182,388 12 31 2012 2013 2014........ 419,207 67.1 480,384 69.0 446,018 63.1............ 96,499 15.5 148,152 21.3 173,189 24.5... 108,819 17.4 67,324 9.7 87,846 12.4........ 624,525 100.0 695,860 100.0 707,053 100.0 7
2012 2013 20132014 (i) (ii)2014 12 31 2012 2013 20132013 2014 20122013 2014 12 31 1.7 6.1 5.0 (i) (ii) (A) (B) 2013 2012 2013 2013 2014 2012201320122013 2013 2014 8
(i) (ii)2014 2014 6 2014 6 2014 12 (i)(ii) 2014 4 30 2015 4 30 36.0% 2.1% 2014 1 14.3% 2014 4 30 34 14.7% 2015 4 3029 2015 4 30 2014 4 30 2015 4 30 200 2015 4 30 264.9 2014 12 317.7 0.12015 4 30 8.3 4400 2015 4 30 9
2015 4 2015 5 4 2015 6 1 (i) (ii) 2014 12 31 2014 12 31 [ ] 40.5[ ]33.3 10.92015 12 31 2015 12 31 30% [ ] [ ] [ ] [][][] [ ] [ ] [ ] [][][] [][][] 10
[ ][ ] 20167585 [ ] [ ] [ ] [ ] [ ] (i) (ii)(iii)(iv) [ ] [ ] [ ] [ ] [ ] [ ] (1)......................... [ ] [ ] (2)................... [] [ ] (1) [ ] [ ] [ ] [ ] (2) [ ] [ ] [ ] 11
2010 11 17 Li Ho Tan Cheung Chi MangFast Sino Holdings Limited 47%50%3% A [ ] 2015 5 26 2011 3 24 V-drug 2012 1 17 V-drugB 12
2015 5 26 [ ] 2013 3 10 1995 2 7 2013 7 22 13
1995 2 23 2002 5 27 2011 6 27 14 6 [ ] [ ] 14 69 [ ] 2010 2 22 80% 32 2219613 14
622 Pa Shun Pharmaceutical International Holdings Ltd.2011 5 3 [ ] [ ] [ ]% 2015 5 26 1. 15
2015 5 26 2007 3 16 [ ] [ ] 1992 2 15 50% 90% 10% [ ] [ ] 16
2006 12 1 Cheung Chi Mang100% A [ ] [ ] [ ] [ ] 17
[ ] [ ] 18
Jumbo Success Jumbo Success Holdings Limited2010 10 29 Li Ho TanJumbo Success[ ] 2015 6 3 [ ] [ ] 2015 5 26 19
[ ] 2011 5 23 1989 4 14 2011 3 9 100% 20
A B [ ] [ ] [ ] [ ] [ ] [ ] S S 2015 5 26 21
A 2014 2014522 A A (2015) 2015 2 12 A A 2011 12 31A 102,912 A 8,000,000 A 0.001 A B 2014 V-drug Jumbo Success 2014 3 13 (1) V-drug2,000 (2) 22
B (2015) V-drug Jumbo Success 2015 2 12 B V-drug 2012 1 6 B V-drug 40,000 B 5,000,000 B 0.001 B 571 0.001 2015526 V-drug Jumbo Success 2012 2 24 23
2008 8 27 2011 2 17 [ ] 15 2014 12 31 [ ] 1993 24
V-drug V-drug Hong Kong Co., Limited2011 4 4 Chubu Yakuhin Co., Ltd.Chubu Yakuhin Co., Ltd. Valor Co., Ltd. V-drug[ ] 2012 5 V-drug 1996 3 27 35%25% 20% % 25
1.00 0.80 7.80 1.00 1.00 0.13 * * [ ] 26
HPV DNA HPV HPV 27
28
(1) (2) (3) (4) (5) (6) (7) (8) 29
8.12 8.12 (a) 3.05 (b) (a) (b) (c) (c) 3A.19 (d) 30
(e) 3.28 8.17 1. 2. 3. 3.28 3.28 3.28 8.17 3.28 8.17 3.28 3.28 3.28 31
[ ] (i)(ii) (iii) 2012 2013 2014 12 31 87.7%87.6% 83.5% 32
28.7%38.2% 43.6% 2003 2012 2013 2014 12 3115.3%8.5% 10.4% 2011 33
201220132014 12 31 1.7 6.1 5.0 (i) (ii) (A) (B) 2013 [ ] [ ] [ ] 2016 75 85 34
2012 2013 2014 12 31 96.5 148.2 173.2 2014 12 31 1,420 201220132014 12 31 30% 35
(i) (ii)(iii) (iv) (v) 36
2011 112013 12 37
20122013 2014 12 31 496.7 588.4629.2 69.8%74.1% 74.3% 38
2012 2013 2014 12 31 37.6 35.2 46.3 91.1%90.5% 92.0%2012 2013 2014 12 31 14.7%12.8% 15.2% 51.6%43.8% 45.3% 39
200 2012 20132014 12 31 100.0% 51.6%43.8% 45.3% 10,000 2007 5 1 2007 2012 2 1 2012 2007 5 1 2012 2 1 2007 2007 5 1 2010 11 2007 40
2012 30 (i) (ii)(iii) 30 2012 100,000 15% 2011 7 27 20111120201231 180 2012 2013 2014 12 31 64.9 69.3 84.7 2014 12 31 41.8 9.1 2012 2013 2014 12 317.5 10.59.3 41
42
43
44
25 45
2012 20132014 12 31 4.8 12.7 30.7 46
2012 20132014 12 31 47
[ ] [ ] [ ] [] 48
50,000201171 2014 12 (i) (ii) 49
2013 6 1 2015 12 31 50
1980 2009 3 18 8,500 (i)(ii) (iii) (iv)(v) 51
2012 3 14 (i) (ii) 52
1979 2007 3 162007 12 6 2008 1 1 25% 25% 25% 2008 1 1 10% 53
25% 5% 2009 10 27 601 601 601 601 20% [ ] 54
698 2009 12 10 698 12.5% 55
10% 698 698 698 698 698 10% 50% 56
[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [][][] [][]%[] [ ] 57
[ ] [ ] [ ] [ ] 58
[ ] [ ] [ ] [ ] 59
[ ] 60
[ ] 61
[ ] 62
Li Ho Tan 29 318 13 1 201 3 4 1501 89 19 1 2 1 30 104 38 1 19 F 63
[ ] 68 23 702 122 2 A 509-201 16 17 [ ] 15 43 518017 6001 12 64
Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY1-1111 Cayman Islands [ ] 39 100022 12 6 16 17 77 9 2 23 753 5 526 [ ] 65
Cricket Square, Hutchins Drive P.O. Box 2681 Grand Cayman KY1-1111 Cayman Islands 183 19 1907B C http://www.pashun.com.cn CPACalifornia Board of Accountancy, CFA 38 1 31B HKICPA, ACCA 29 37 1001 38 1 31B 29 66
58 39 [ ] [ ] 67
[ ][ ] [ ] 477,000 (i) (ii) 68
2008 4,585 2013 10,985 19.1% 2013 2016 14.6%2016 16,53420082016 2,000 20082013 19.1% 20132016 14.6% 1,653.4 1,500 1,442.2 1,000 500 458.5 553.5 675.0 809.7 955.5 1,098.5 1,248.4 0 2008 2009 2010 2011 2012 2013 2014 2015 2016 69
2013 56.9 2008 15,781 2013 26,95511.3%2008 4,761 2013 8,896 13.3% 2016 34,618 12,3322013 2016 8.7% 11.5% 45,000 40,000 35,000 30,000 25,000 20,000 15,000 10,000 5,000 4,761 15,781 5,153 17,175 20082013 13.3% 20132016 11.5% 5,919 19,109 6,977 21,810 20082013 11.3% 20132016 8.7% 26,955 24,565 7,919 8,896 12,332 34,618 0 2008 2009 2010 2011 2012 2013 2016 (1) 20082012 (2) 20132016 2014 2008 14,535 2013 31,869 17.0% 2012 7.0% 18.0%2012 70
5.4%2013 201617.9% 2016 52,199 2008155 2012 32220.1% 2012 322 3.6%6.8% 18.9% 2008 345 2013 807 18.5%2013 2016 13.8% 1,500 20082013 18.5% 20132016 13.8% 1,189 1,000 500 345 415 503 601 706 807 919 1,045 0 2008 2009 2010 2011 2012 2013 2014 2015 2016 (i) (ii)(iii) 2014 573 71
2013 78.4% 802 98.7% 50% 2010 178 60 13.3% 2030356 2008 1,2952013 2,558 14.6% 20163,642 400 20082013 14.6% 20132016 12.5% 323.7 364.2 300 200 129.5 148.7 173.9 200.0 226.8 255.8 287.8 100 0 2008 2009 2010 2011 2012 2013 2014 2015 2016 72
2013 7,000 4,535 1,397 2013 6 1 (i)(ii) (iii) 73
(i) (ii) OEM 2008 3,404 2013 10,429 25.1%2016 18,707 2,000 20082013 25.1% 20132016 21.5% 1,870.7 1,500 1,266.1 1,544.8 1,000 742.6 890.6 1,042.9 500 340.4 419.7 538.6 0 2008 2009 2010 2011 2012 2013 2014 2015 2016 74
201280.8 29.5 34.5 46.62012 14.2%2008 2013 2009 2013 2009 2016 30% 27.20% 25% 25.32% 24.48% 24.35% 20% 15% 10% 5% 12.50% 18.75% 7.90% 7.55% 21.49% 19.84% 19.96% 17.26% 16.28% 20.44% 16.98% 13.45% 13.06% 18.77% 17.10% 9.58% 9.48% 9.75% 17.20% 13.01% 9.00% 8.63% 8.95% 12.54% 11.83% 6.47% 8.15% 7.94% 12.00% 11.13% 6.62% 12.67% 9.84% 7.64% 7.95% 6.33% 0% 2009 2010 2011 2012 2013 2014 2015 2016 2012 2 2011 201265 9.8%658.9% 75
300 283.9 250 234.4 200 192.0 150 100 110.7 132.1 159.2 50 31.2 37.4 57.6 0 2008 2009 2010 2011 2012 2013 2014 2015 2016 2008 2013 38.5%2013 2016 21.2% (i) 2009 (ii) (i) (ii)65 76
2,500 2,000 1,545 1,593 1,647 1,714 1,780 1,848 1,914 2,008 1,500 1,000 500 0 2011 2012 2013 2014 2015 2016 2017 2018 2011 2012 2013 12 31 29.2%28.8% 30.3% 2011 2012 2013 (2) (2) (2) % % %............................ (1)........................ (1).......... 207 45.9 211 46.1 218 43.6 105 23.2 113 24.8 118 23.7 50 11.0 39 8.8 48 9.6 40 8.8 40 8.5 42 8.4 33 7.4 35 7.5 38 7.7 77
(1) 2012 (2) (i) (ii) (iii) 78
1984 9 202001 2 282013 12 28 2015 4 24 2002 8 4 2002 9 15 2015 4 24 14 (1) 1002015(2)55 (3) 2015 5 4 79
2015 6 1 80
2002 2 11 2002 4 1 2015 3 10 2015 4 10 2000 7 25 2000 9 1 2011 1 172011 3 1 81
2011 8 2 2007 7 10 82
2004 4 1 2013 1 22 2013 6 1 2000 11 16 2013 6 1 83
2013 8 29 2014114 (i) 2 (ii) 50110 51-200115201-500 120500 125 2013 6 24 2013 12 31 2014 6 3020151231 2016 1 1 2007 1 31 2007 5 1 84
2003 6 2003 8 28 2013 100% 2005 1 10 2005 3 1 2011 1 27 (i) (ii)(iii) (iv) 2011 11 18 2011 5 5 (2011 2015) 85
2004 7 8 1999 6 2000 1 1 2005 11 1 86
2009 8 18 2009 2014 3 7 2014 6 1 2014 6 1 2004 8 9 87
1995 10 30 2009 6 1 1996 3 151996 6 1 2009 7 30 20131231 1998 12 14 1999 5 12 88
10.0 10.0 20.0 2006 2006 1 10 10.0 20.010.0 2001 2 28 2000 7 20 2005 8 1 2010 3 5 2005 2009 9 89
2006 5 19 115% 125% 2009 11 9 2015 4 24 14 55 90
2015 5 4 2015 6 1 19941027199521 91
1993 12 1 10,000 200,000 19961115 1997 10 1 2008 11 20 1999 3 151999 10 1 1987 1 1 92
1993 2 22 2000 7 8 1993 10 31 2013 10 25 2007 5 1 2007 2012 2 1 2012 2007 5 1 15 30 331 2012 2 1 2007 2007 5 1 1 2012 30 iii iii 93
2007316200811 2008 1 1 25% 15% 2011 7 27 2011 1 1 2020 12 31 15% 1993 12 13 2008 11 102009 1 1 17%13% 1993 12 13 2008 11 5 1996 1 29 2008 8 1 2005 10 21 75 2005 11 1 75 (i) 94
(ii) (iii) 30 75 75 2014 7 14 3737 75 (a) (b) 37 2015 2 132015 6 1 (1) (2) (i) (ii)(iii) 95
2006 8 8 2006982009622 (i) (ii) 200812272009101 20 10 1982 20012013 2002 2014 2004 7 1 2012 11 9 96
1989 12 26 2008 8 1 2005 1 1 2009 8 27 2007 6 29 2008 1 1 2012 12 282013 7 1 2008 9 3 2010 10 28 2011 7 1 1999 1 22 1994 12 14 1995 1 1 2003 4 27 2004 1 1 2010 12 201999 1 22 1999 4 3 97
2002324 98
1989 1995 2001 2002 2003 2009 1,000 2011 A [ ] 2012 V-drug [ ] V-drug 2013 30 2014 2013 99
1989 4 1995 2 1995 2 1995 2 23 10 95% 5% (i)(ii) (iii) 2014 4 10 2014 4 11 2004 11 10 5% 500,000 2004 12 1 2011 1 1710 43 2012 5 7 74 100
2001 5 25 500,000 90% 10%2002 4 26 1.8 0.2 2.5 2003 6 2 13.9 6.222.6 71.46%28.54%2005 2005 3 1 22.6 2005 3 25 70% 30% 200731530% 6.78 2007 4 5 30%40% 30% 2007 4 16 15.82 2007 4 19 2005 3 2007 3 101
2002 5 27 2 95% 5% 2003 7 24 5.7 0.3 8 2005 2005 3 1 7,600,0002006 4 25 70% 30% 2007 4 26 7,600,000 2007 5 11 2008 7 9 5200879 20022003 2005 2007 102
2010 2 22 1 30%50%5%5%5% 5% 2011 7 19 40% 400,000 40% 200,00020% 2011 7 20 90% 10%2011 11 11 4,000,0004,000,000 80%2011 11 16 580%18%2% 2013 11 1 10,000,000 2013 12 26 2012 6.92012 2011 11.0%2013 12 26 2013 12 31 103
2013 7 22 2 201153380,000 380,000,000 0.001 Codan Trust Company (Cayman) Limited 0.001 2011 5 23 50,00050,000 1 50,000 50,000 1 19894141,000,000 10,000 100 10,000 50%2000 5 9 1,0004,000 5,000 2000 5 9 60% 40%2008 7 9 6,000 60% 40%2011 12 23 10,000,000 100,000 100 104
[ ] [] 60% 40% 100% 100% 100% 100% 100% 15.38% (1) (1) 84.62% 105
(a) 2011 5 3 380,000 380,000,000 0.001 Codan Trust Company (Cayman) Limited 0.001 (b) 2011 5 23 50,000 50,000 1 50,000 50,000 1 (c) 2011 11 11 4,000,000 80%4,000,000 2011 11 16 80%18% 2% (d) 2011 12 23 4,000 40%400,000 (e) 2011 12 239,790,980 90,000 90% 10% 90% 106
(f) 2011 12 30 10,000 10% 857,087 100% 857.088 857,088 0.001 (g) 20111231A 8,000,000 102,912 A 154,368 12,000,000 AA2011 12 31 A [ ] (h) 2012 1 6 V-drugB V-drug40,000 B 5,000,000 [ ] (i) 2012 1 9 Jumbo SuccessJumbo Success 50,000 3,731,300 [ ] 107
(j) 2011 4 15.38% 20 2012 3 1 20 2012 3 7 (k) 2011 12 16 5,000,000 2012 1 9 108
(l) 2012 6 14 1,500,000 2012 6 29 (m) 2013 7 22 2 (n) 2013111 10,000,000 2013 12 26 2013 12 26 109
[ ] (i) [ ] (ii) [ ] (a) 20111231A 8,000,000 102,912 A 154,368 12,000,000 A A 2011 12 31 A (b) 2012 1 6 V-drugB V-drug40,000 B 5,000,000 (c) 2012 1 9 Jumbo SuccessJumbo Success 50,000 3,731,300 (d) 2012117V-drug (e) 2012 2 24 V-drug Jumbo Success [ ] (f) 2014 3 13 V-drug Jumbo Success B2014 (i)v-drug V-drug2,000 (ii)v-drug 2014 12 31 110
(g) 2014 5 22 A 2014(i)A (ii)2014 12 312012 12 31 (iii)a2011 2014 12 31 (h) 2014 12 31A (2014) 2015 2 12 A (2014)A(2015)A (2014) A (2015), (i)a (ii)2015 12 312012 12 31 (iii)a2011 2015 12 31 (i) 2014 12 31B (2014)2015 2 12 B (2014)B(2015)B (2014) B (2015)V-drug 2015 12 31 111
[ ] V-drug Jumbo Success........... Cheung Chi MangLi Ho Tan Fast Sino Holdings Limited50% 47% 3% Chubu Yakuhin Co., Ltd Valor Co., Ltd. 100% V-drug Li Ho Tan 100%Jumbo Success....... 102,912 A 154,368 2012 2 27 A 40,000 B B B 2014 3 13 V-drug2,000 V-drug [ ] [ ] [ ] 50,000 Jumbo Success[ ] [ ] [ ] A [ ] [ ] [ ] 112
V-drug Jumbo Success......... 2011 12 31 2011 12 31 2012 1 6 2012 1 9 2014 5 22 A 2014 2014 3 13 B 2014 2015 2 12A (2015) 2015212B(2015).................. 8,000,000 (i) 6,000,000 (ii) 2,000,000 12,000,000 (i) Jumbo Success 65,000,000 10,000,000 (ii) 2012 3 31 5,000,000 3,731,300 Jumbo Success (i)jumbo Success 10,000,000 1,538,462 (ii) 2012 3 31...................... 2012 2 2 2012 2 10 2012 2 27 2012 1 18..... [ ] [ ] [][ ][] [][ ][] [ ] [ ] [ ] [ ] [][ ][] [][ ][] [ ] [ ] [ ][ ] [ ] [ ] [ ] [][][ ] [ ] [ ] [ ] [][ ][] [ ] [ ] [][ ][] [ ] 113
V-drug Jumbo Success...................... (1)A (i)2010 12 31 12 45,000,0002010 (ii) 2011 12 31 12 75,000,000 2011 2010 12 3112 2010 2010 1 2010 2010 1.1 360 2010 2010 10% 2011 12 31 12 2011 2011 1 2011 2011 1.1 360 20112011 10% A (2014) A (2015) (2)A 50%A (1) (i) V-DrugB 5,000,000 B (ii) V-drug V-drug 2012 5 V-drug (iii) V-drug (a) (a) (i)2012 12 1212 70%(ii) 2013 12 3112 70%(b) V-drug V-drug (1)Jumbo Success Jumbo Success (2) A B (i) (ii) (iii) 114
V-drug Jumbo Success (3)A B AB (4) (5)A B (i) (ii) (iii) (a) 5,000,000 50% (b) 10 (a) 2014 12 31 12 70%(b) (a)2014 12 3112 50%(b) V-drug (3)Jumbo Success (6)A A 115
V-drug Jumbo Success (7)A A (8)(a)A A A (b)a A (i) (ii)a (9)A (a) 2012 12 31 (b) A (c) 20102010 70% 20112011 70% A A (a) (b) A 10% (c)a (a) (b) 10 (b) V-drug V-drug V-drug B V-drug V-drugV-drug V-drug 5,000,000 x (1+20%) x D365D 1,825 5x365 116
V-drug Jumbo Success (10) (c)v-drug V-drug 1 V-drug B (2014) B (2015) 2014 12 31 V-drug (2)V-drug B 50%V-drug B (3)A B A B 117
V-drug Jumbo Success (4)V-drug V-drug (5) A B (i) (ii) (iii) (6)B B 118
V-drug Jumbo Success (7)B A B B B B A A A 77.74 A (8)(a)B B B (b) B B (i) (ii) B 119
V-drug Jumbo Success (9) B B B B (a)(b)b 10% (c)b (10)V-drug V-drug.......................... V-drug 10%V-drug Jumbo Success Li Ho Tan Jumbo Success 120
(i) (ii) V-drug Chubu Yakuhin Co., Ltd200 Valor Co., Ltd. Chubu Yakuhin Valor Co., Ltd [ ] 2010 10 13 HKEx-GL29-12HKEx-GL44-122012 10 HKEx-GL43-12 2012 10 2013 7 121
[ ] [ ] [ ] [ ] 100% Fast Sino Holdings Limited Cheung Chi Mang Li Ho Tan 3% 50% 47% 100% 100% Valor Co., Ltd. 100% Jumbo Success V-drug 65.07% 25.73% 5.00% 4.20% 100% 100% 100% 100% 100% 100% 80% 100% (1) (1) 18% 2% 122
[ ] [ ] [ ] [ ] 100% Fast Sino Holdings Limited Cheung Chi Mang Li Ho Tan Valor Co., Ltd. 100% 3% 50% 47% 100% 100% Jumbo Success V-drug 100% 100% 100% 100% 100% 100% 80% 100% (1) (1) 18% 2% 123
2014 7 14 37(a) (b) 37 37 2006 8 8 2006 9 8 2009 6 22 (i) (ii) 124
2013 12 31 2013 2011 20122013 40% 20112012 2013 0.06%0.05% 0.05% (i)(ii)(iii) 2014 12 31 2,690 700 1,420 560 2003 2014 12 31 27 2011 11 2013 12 125
2011 2012 2013 2012 12 31712.1 2013 12 31 794.3 2014 12 31 847.22012 20149.1% 2010-2015 2014 12 31 2,6907001,420 560 2013 126
20132003 1989 2013 12 31 30 2014 2011122010 13 2011 20122013 40% 127
(i) (ii) (iii) 2014 12 31 13,154 180 300 59.4% 302003 20 128
2014 1 25 2015 1,000 10,0002014 12 2015 129
2015 3,000 HPV 130
25,000 300,000 [ ] [ ] [ ] [ ] 201572015920164 2015 102016 2 6 2016 7 201675 85 2014 12 31 27 131
(i) (ii) (iii) 2014 12 3127 11 2014 12 31 1,010.0 160.0 45.0 2012201320141231712.1 794.3847.2 132
12 31 2012 2013 2014............. 624,525 5,640 630,165 695,860 7,385 703,245 707,053 6,524 713,577........ 7,831 7,831 17,626 17,626 29,352 29,352................. 79,755 30,281 110,036 80,863 24,511 105,374 110,788 22,136 132,924................ 712,111 35,921 748,032 794,349 31,896 826,245 847,193 28,660 875,853 12 31 2012 2013 2014............. 7,583 14,794 24,651........... 248 2,832 4,701 2013 12 31 2013 2014 12 31 2,690700 1,420 560 20122013 2014 12 31 624.5695.9 707.1 87.7%87.6% 83.5% 133
12 31 2012 2013 2014 % % %............ 419,207 67.1 480,384 69.0 446,018 63.1..... 96,499 15.5 148,152 21.3 173,189 24.5........... 108,819 17.4 67,324 9.7 87,846 12.4............... 624,525 100.0 695,860 100.0 707,053 100.0 12 31 2012 2013 2014 % % %.............. 58,695 9.4 41,717 6.0 36,045 5.1.............. 18,608 3.0 12,686 1.8 27,240 3.9.............. 29,823 4.7 33,073 4.7 19,296 2.7............ 29,878 4.8 26,968 3.9 8,901 1.3............ 2,451 0.4 2,640 0.4 2,056 0.2............ 485,070 77.7 578,776 83.2 613,515 86.8.................. 624,525 100.0 695,860 100.0 707,053 100.0 134
2014 12 31 700 1,420 560 (1)...................... 48...................... 27...................... 22.................... 37.................... 13.................... 556 1,422 562.......................... 703 1,422 562 (1) (A) (B) 135
A B (1) (1) 136
A B 2012 2013 2014 12 31 419.2480.4446.0 67.1%69.0% 63.1% 2012 2013 2014 12 31 1.0%1.3% 0.9% 137
15,000 30 180 138
12 31 2012 2013 2014........................ 1,211 1,296 1,019...................... 444 270 121...................... 359 547 437................ 85 (277) (316)........................ 1,296 1,019 703 (i) (ii) (iii) 50,000 20122013 2014359 547 437 318 505 394 50,000 90% 2012 2013 2014 40(i) (ii) 2014 12 31 2014 4 5 139
2012 2013 2014 2011 2012 2013 12 31 25.1 49.1 66.82011 2012 2013 12 31 1.7 1.6 1.0 23.4 47.5 65.8 2012 2013 20142011 2012 2013 12 31 3.52.30.9 2011 2012 2013 12 31 0.20.1 64,3293.2 2.2 0.8 2012 20132014 12 31 96.5 148.2 173.2 15.5%21.3% 24.5% (i)(ii)iii (iv)(v)(vi)(vii) 2012 2013 2014 12 31 7.0 10.9 13.8 140
2014 1 2013 6 25 2015 1 30 (i) (ii) (iii)(iv) (v)(vi) 141
(i) (ii) (iii) 5,000 (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) (ix)20 2012 2013 2014 12 311,411 1,391 1,416196 200 173 142
30 2014 12 31 1,422 12 31 2012 2013 2014.......................... 1,093 1,112 1,104............... 359 285 318.......................... 1,452 1,397 1,422 143
12 31 2012 2013 2014........................ 1,437 1,452 1,397..... 33 2 75........................ 18 57 50.............. 15 (55) 25........................ 1,452 1,397 1,422 2012 2012 2013 2014 (i) (ii) 144
(iii)(iv) (v) (i) (ii)(iii) 145
2013 2009 2013 2009 2010 2011 2012 2013 2005 113 2011 181 113 181 181 113 181 181 113 90 146
201220132014 12 31 1,030 647 562 2012 2013 2011 11 2012 2013 2014 10,000 2014 12 2015 92 24 147
2014 12 31 13,154 5% 12 31 2012 2013 2014.................. 4,350 3,744 3,506............... 4,494 3,953 3,834........ 2,156 1,630 1,463............. 1,155 913 683............. 442 450 406........... 22 4,114 2,718................. 242 999 544 (i) (ii) 148
(1)...................... 9.30 10.80...................... 8.40 12.20................... 6.10................... 17.00 18.40................. 14.10 19.60................. 18.50 20.00................. 276.00 340.00................. 600.00 780.00 (2)................. 4.00 4.60................. 5.00 5.85.............. 109.00 128.00.............. 154.00...................... 12.40 12.60...................... 41.00 58.00 (1) (2) 149
2012 2013 2014 12 31 14.2%24.4% 32.3% 30.2% 33.9% 41.7% 2014 12 31 27 2012 2013 2014 12 31 7.8 17.6 29.4 12 31 2012 2013 2014 (2)........................ 7 10 8........................ 8 14 (1) 11 (3)...................... 10 8.......................... 15 34 27 (1) 2013 12 31 (2) 2014 12 31 (3) 20132014 12 31 150
2014 12 31 27 12 31 2012 2013 2014........................ 3 15 34......... 12 19....... 7 12 19 (7) (1)........................ 15 34 27 (1) 2014 12 31 2011 11 2013 12 2014 12 31 80% 90%10%20111180% 151
2014 12 31 11 2013 11 100% 2014 12 31 (i) (ii) (iii) 2014 12 31 2012 1 17 V-drug V-drugV-drug Valor Co., Ltd.995625 Chubu Yakuhin Co., Ltd100% V-drugChubu Yakuhin Co., Ltd Chubu Yakuhin Co., Ltd Valor Co., Ltd. Chubu Yakuhin Co., Ltd 152
2014 12 31 4.7 16.0%....................................................... 400 160........ 10 4 2014....................... 1,262 867 2016 75 85 1.2 2015 201643.5 68.0 [ ] (i) 60 (ii)32 (i)375 (ii)250 153
(i) (ii) (A) (B)2013 V-Drug 30 2014 12 31 36,000 25,000 25,000 2011 2013 2016 20.8%20.8% 20.9% (i)1000 (ii) 5,000 154
2016 4 2016 7 [ ] 5,000 20,000 2014 7 (i) (ii)20145 (iii) 155
2015 12 31 2015 12 31 17 10 20 156
76.5% 2014 1 25 157
12 31 2012 2013 2014................. 3,979 3,623 3,790............... 4,174 3,827 3,530........ 468 1,263 1,673............. 420 621 206 OMEOK........ 100 169 211............. 725 354 2,374 By-health Alivegreen SI-KI Shijian... 728 1,282 2,243 Momcen Doctor Radiation 158
(1)...................... 30.00 50.00...................... 15.84 18.00................... 450.00 468.00................... 5.00 6.50............ 378.00 480.00............ 226.00 260.00 (2)................. 16.00 19.00................. 81 48.00............ 498.00............ 26.00 32.00................. 99 45.00 98.00................. 112.64 128.00 79.50 79.80................ 318.00 518.00................ (1) (2) 159
2013 2014 1 25 20112012201340% 201220132014 12 31 79.880.9110.8 11.2%10.2% 13.1%2012 2013 (i) 160
(ii) 2013 2014(i) (ii)............... (1)....................................................... (2).......... (3) 161
(1) (2) 20142212019220 (3) 2015 19 162
............. 24.625 2.00 3.90 19.7 1.90 3.90 5.4175 0.50 1.30 24.625 3.30 6.50............... 27 10.76 17.09 16 4.00 6.50............... 5.4175 2.00 3.60........ 6 2.70 5.20 9 4.80............. 20 0.75 2.80.... 6 4.00 6.00 12 31 2012 2013 2014........................ 1 0.14 0.13 0.14.......................... 1 0.54 0.53 0.53.......................... 1 0.41 0.38 0.39................... 1 0.53 0.48 0.49........... 1 0.08 0.03 0.07............... 1 0.69 0.85 0.85 2012 0.14 20130.13 20132014 0.14 163
2012 2013 2014 12 31 91.1%90.5% 92.0% 45 164
2011 1 5 (1) 45 12 23 210 1 530 165
(1) D 1826 45% 65% 2012 2013 2014 12 31 2012 12 31 2013 12 31 2014 12 31 % % %................. 1,010,000 606,086 60.0 1,010,000 653,358 64.7 1,010,000 810,743 80.3................. 160,000 4,511 2.8 160,000 7,892 4.9 160,000................. 45,000 10,016 22.3 45,000 10,162 22.6 45,000 15,732 35.0 (1) 2012 20132014 12 318 240 (2) 1,000 (3) 2012 2013 12 31 2012 2013 2014 12 31 (i) (ii) 2014 12 31 20155 166
1 2002 4 15 2015 10 2015 11 2015 9 2 2010 2 15 2015 10 2015 11 2015 9 3 2002 1 15 2015 11 2015 10 2016 10 4 2002 2 15 2015 11 2015 10 2016 10 5 2006 6 15 2015 12 2016 3 2016 9 167
6 2010 1 15 2015 12 2015 9 2016 3 7 2003 9 15 2015 12 2015 9 2016 3 8 2009 1 15 2015 12 2016 2 2017 10 9 2010 12 15 201220132014 12 31 168
30 12 31 2012 2013 2014.......................... 195 201 195.................... 13 11............... 7 17 2.......... 6 (6) (2).......................... 201 195 193 169
201220131231(i) (ii)(iii) 2014 2012 20131231(i) (ii)2014 12 31 12 31 2012 2013 2014.......................... 355 345 351................. 13 22 5............. 23 16 1........ (10) 6 4.......................... 345 351 355 2012 2013 2014 12 31(i) (ii) 170
(i) (ii) (i) (ii) (i)(ii) (iii) (iv) 90 180 3% 171
(i)(ii) 50%(iii)(iv) (v)(vi) (i) (ii) 10% 2,000 50 2012 2013 2014 12 31 16.5%25.4% 29.5%4.6%9.5% 8.0% 172
2012 2013 2014 12 31 5% 2012 20132014 12 31 145.6 173.9 239.1 2012 20132014 12 31 7.5 10.5 9.3 2014 12 31 (1) E 30 180 M 30 B 30 180 J 30 O 30 (1) 173
2013 12 31 (1) A B C D E 30 180 30 30 30 180 (1) 174
2012 12 31 (1) C B E F D 30 180 180 180 30 (1) 175
2014 12 31 1932012 2013 2014 12 31 11.2%10.2% 13.1% 2012 2013 2014 12 31 28.7%38.2% 43.6%9.8%9.8% 13.7% 2012 2013 2014 12 31 5% 2014 12 31 (1) E H K J F 30 30 0 30 30 180 (1) 176
2013 12 31 (1) A 30 H 30 C 30 E 30 D 30 (1) 2012 12 31 (1) E 30 C 30 D 30 I 30 H 30 (1) 177
(i) (ii)30% 50% (iii)30 90 90 30 90 (i) (ii) 30%(iii)30 90 178
2012 2013 2014 12 31 2012 2013 2014 12 31 45.265.470.56.3% 8.2% 8.3%2012 2013 2014 12 31 64.8 103.5 75.011.1%16.1% 11.3% 2012 12 31 1.1% 2013 12 31 0.2%2014 12 311.0% 201220132014 12 31 296.2376.8363.7 426.7 487.0 395.2 13.2%13.0% 11.9%20122013 2014 69.8161.7 106.3 124.6 197.1 128.3 2012 20132014 7.1%3.8% 4.8% 179
(i) (ii) (iii)(iv) 180
(i) (ii) (iii) (i) A(ii)B (iii)c 181
5656 16 182
75 30 1999 11 2012 12 (i) (ii) 183
(i)(ii) (iii) 2013 12 15 2014 1 1 2023 12 31 184
HPV(i) (ii) (i) HPV (ii)(iii) (iv) (i)20.0 (ii)(a)3.0%(b) 2.0% 2015 4 2015 5 4 2015 6 1 (i) (ii)(iii) (iv) 185
30 180 30 90 90 2012 4 27 20122013 2014 12 31 0.9%1.2% 0.8% 9229 200 200 186
2014......... 2014 2014......... 2013 2013......... 2012 AA 2012......... 2011 12 2011......... 2010 13 187
2010......... 2009 16 2010......... 188
........ 2011 2010 2014 2014 1 189
2014 7 2014 10 (i)(ii) (iii)(iv) 190
2014 7 2014 10 (i) (ii) 191
444.......................................................... 40...................................................... 92...................................................... 65.......................................................... 11.......................................................... 45...................................................... 75.................................................... 22...................................................... 56............................................... 25.......................................................... 13.......................................................... 444 192
2012 39.8% 2012 193
2012 12 31420,000 194
6,419.17 3,176 33,600.17 999.4 1,040 2,829 195
11,637 2011 1 100.0% 20122013 2014 12 31 51.6%43.8% 45.3% 21,313.3 4,590.6 20 2008310 30 30 23 72016 2009 2 2009 5 2013 12 2016 2017 196
201457 2014 6 20 (1) (2)(3) (4) (5) 2015 4 29 2014 9 2014 10 (1) (2) (3)2016 201411 197
2015 4 (1) (2) (3) (4) (1) (2)(a) (b) 1% 2%5% 10% 37.6 33.84.1 (3) (4) (5) 198
(1) (2) 14(3)5 1. 50 2. 2014 11 3 2014 11 3 199
10% 2015 2.8 2014 11 100% 3. 2014 6 200
2014 12 (a)15 (b) (c) (d)(e) 2014 10 31 (a)(b) (c)(d) 201
36 31,799.28 36 28,999.28 2015 6 2021 12 1 2,800 2021 12 (1) (1) (A) 1614 202
16 16 (B) (C) 1,000 10,000 1,000 10,000 203
20122013 2014 12 311.1%2.1% 3.4% 20122013 2014 12 31 0.7 1.2 0.7 0.1%0.2% 0.1%(i) (ii)(iii) (iv) (v) 3.4 41 2,085 2014 6 6(1) 1% 15% 38(1)34(2) 204
2008 8 1 (i) (ii) (iii)(iv) (v) 205
26 2015 2014 2 21 2019 2 20 206
(I) 2014 12 31 5.7 2011 7 1 0.2%2011 7 1 0.05% 5.7 2014 6 23 2014 12 31 2014 6 2014 12 2012 2013 2014 12 31 (i) ;(ii) (iii) 2011 2010 2014 2014 1 207
(II) 2014 12 31 6.5 10,000 50,000 2.7 2014 6 2014 12 2012 2013 2014 12 31 2011 2010 2014 2014 1 208
(1) (2) (3) (4) 2014 1 3.08 3.098.04 209
3.08 3.098.04 210
[ ] 30% [ ] (i) (ii) [ ] [ ] 211
1996 3 27 35%25% 20% 2015 12 31 2014 12 31 931,926.93 106,443.66 535,781.99 1........................................................................................................................................................................................................................................................................................................... 212
2014 7 2014 8 6 2014 8 13 2. 2013 2012 2013 2014 12 31 262,000 29,000 3. 4. 1992 2 15 90% 10% 50% 213
2014 12 31 2,632,938.63 571,157.81 96,603.41 1................................................................................. (II)............................................................................................................................................................................................................................................................................................................................................................................................................. 2. 2013 2012 2013 2014 12 31 3,054,000 1,186,000 85,396 2013 11 214
2014 6 3. 4. (i) (ii) (a)(b) 215
(a) (i) 5% (ii) 5% (b) (i) (ii) (iii) 30% (i) (ii) 216
(iii) (iv) (v) (vi) 217
2015 5 26 67 1989 2011 43 1993 2012 43 1998 2012 58 1999 2012 218
Li Ho Tan 50 2012 2012 42 2012 2012 51 2015 2015 52 2015 2015 64 2015 2015 219
46 2008 2010 53 2011 2011 46 1998 1998 34 2014 2014 52 2011 2011 36 1999 2013 38 2015 2015 220
67 2011 5 3 30 1995 1989 1987 7 19986 2003 2006 2010 13.51(2) 43 2012 2 27 18 1993 2010 2012 2008 2013 12 2010 9 2011 12 2001 7 1997 7 13.51(2) 221
43 2012 2 27 151998 20115 2006 6 13.51(2) 58 2012 2 27 301999 1991 1998 1979 1991 1992 2 1996 11 13.51(2) LI HO TAN50 2012 2 27 Li2009 6 Li1984 7 13.51(2) 42 2012 2 27 2009 2007 6 2009 1 2001 1 2007 6 Goldman Sachs Japan Co., Ltd1997 4 2000 12 19973 13.51(2) 222
51 2015 5 26 302004 1992 2001 19861989 2004 6 17 1992719867 13.51(2) 52 2015 5 26 26 2011 3 195 2009 12 8175 2010 1 2011 2 8192 223
2006 4 2009 9 547 2007 6 2008 1 2349 2006 4 2007 5 8047 2003 1 2003 4 8010 2000 3 2003 11 307 2001 8 2003 4 2000 3 2001 10 2001 102002 6 2002 6 2003 11 224
1999 12 2000 2 1991 7 1999 4 2004 1 2006 4 Chu Lung Hai, Jimmy & Co. CPA 1989 1 19896Deloitte Haskins & Sells 1985 11 1988 1 1989 4 (University of New England) 1985 7 (University of Southampton) 1991 1 1989 113.51(2) 64 2015 5 26 30 1994 2001 1992 6 1998 12 20 1982 1 2000 8 18 13.51(2) 46 2010 2008 202008 20121999 200819931999 1991 7 225
53 2011 30 20072011 2005 2007 1978 20052006 6 19971990 6 46 1998 161998 3 1996 2 1998 2 1994 7 1996 2 1994 7 3420142 82008 9 2013 11 2006 6 2009 7 2012 8 52 2011 30 2011 2000 122011 5 1993 2000 10 226
2000 6 1999 112012 12 36 15 1999 2007 6 30 38 2015 1 10 2011 4 2014 12 2010 9 2011 4 2008 3 2010 9 2003 7 2006 2 Ernst & Young LLP2007 2 2007 10 2007 112008 3 2003 5 1999 8 2006 2 California Board of Accountancy2006 11 (CFA) 2015 5 26 10 (York University) 227
8.12 8.12 3A.19 13.46 (a) 3A.19 13.46 (b) (c) (aa) (bb)(cc) (d) 3A.26 60 228
(e) 3.21 C.3 2015 5 26 3.10(2) B.1 2015 5 26 2015 5 26 229
D.3 2015 5 26 2012 2013 2014 12 31 620,000 696,000553,000 [ ] 2012 2013 2014 12 31 201220132014 12 31 915,000 999,000 1,386,000 201220132014 12 31 2012 2013 2014 12 31 2012 20132014 12 31 2015 12 31 0.9 230
[ ] [ ] 2,000,000,000 2,000,000 [ ] (%) 1,000,000 1,000 0.10 [ ] [ ] [] [ ] [ ] [ ] [] [ ] [ ] 100.00 [][] 2,000,000,000 2,000,000 [ ] (%) 1,000,000 1,000 0.10 [ ] [ ] [] [ ] [ ] [ ] [] [ ] [ ] [ ] [] [ ] [ ] 100.00 231
[ ] 2. 2(c) (i) []20%[ ] (ii) (i) (ii) (iii) 232
2015 5 26 [ ] 10% [ ] (i) (ii) (iii) 2015 5 26 233
[ ] [ ] XV23 10% [ ] (1).............. 650,720 65.07% [ ] [] (1)................ 650,720 65.07% [ ] [] Li Ho Tan (2)........ 307,280 30.73% [ ] [] (2)(3)............... 257,280 25.73% [ ] [] Cheung Chi Mang (3).. 257,280 25.73% [ ] [] (1) [ ] (2) Li Ho Tan47% Jumbo SuccessLi Ho Tan Jumbo Success[ ] [ ] (3) Cheung Chi Mang50% Cheung Chi Mang [ ] [ ] [ ] XV23 10% 234
2012 2013 2014 12 31 (i)(ii) (i)(ii) (iii) 2013 12 31 2013 2014 12 3127 235
2011 20122013 40% 2011 2012 2013 0.06%0.05% 0.05% 20115320111230 2011 2012 2013 8,097 9,555 10,985 2016 16,534(i) (ii)(iii)(iv) (v)(vi) 2008 2013 38.6% 236
200920092011 8,500(i) (ii)(iii) 2012 20132014 24.3%18.6% 27.6% 2011 2013 237
2014 12 31 13,154 238
20122013 2014 12 31 91.1%90.5% 92.0% 201220132014 12 31 12 31 2012 2013 2014 % % % 5%.................... (27,519) (296)% (30,305) (48)% (30,423) (66%) 3%.................... (16,511) (177)% (18,183) (29)% (18,254) (40%) 1%.................... (5,504) (59)% (6,061) (10)% (6,085) (13%) 5%.................... 27,519 296% 30,305 48% 30,423 66% 3%.................... 16,511 177% 18,183 29% 18,254 40% 1%.................... 5,504 59% 6,061 10% 6,085 13% (i) (ii) 239
240
i. ii. (ii)(i) 241
242
20 30 3 10 5 10 3 10 4 10 243
244
12 31 2012 2013 2014................................... 712,111 794,349 847,193................................. (582,575) (643,924) (665,126)..................................... 129,536 150,425 182,067................................. 10,379 14,612 20,672..................... 354 33 (710).......................... (33,380) (35,990) (36,468).......................... (25,137) (25,779) (46,729)................................. 81,752 103,301 118,832................................. (3,453) (5,855) (9,013)................................. (4,714)......... (51,881) (16,134) (33,236)............................... 26,418 81,312 71,869................................... (17,110) (18,243) (25,740)................................. 9,308 63,069 46,129...................... 9,409 63,070 45,944............................. (101) (1) 185....................... 1,713 5,396 (5,929).......................... 11,021 68,465 40,200........................... 11,122 68,466 40,015.................................. (101) (1) 185.......................... 11,021 68,465 40,200 (1)......................... 61,189 79,203 79,365 245
(1) (i)(ii)(iii) 2012 2013 2014 12 31 712.1 794.3 847.2 12 31 2012 2013 2014............ 624,525 5,640 630,165 695,860 7,385 703,245 707,053 6,524 713,577....... 7,831 7,831 17,626 17,626 29,352 29,352................ 79,755 30,281 110,036 80,863 24,511 105,374 110,788 22,136 132,924................ 712,111 35,921 748,032 794,349 31,896 826,245 847,193 28,660 875,853 246
12 31 2012 2013 2014............. 624,525 74,147 11.9% 695,860 89,755 12.9% 707,053 98,595 13.9%......... 7,831 3,092 39.5% 17,626 5,621 31.9% 29,352 9,827 33.5%.................. 79,755 52,297 65.6% 80,863 55,049 68.1% 110,788 73,645 66.5%................ 712,111 129,536 794,349 150,425 847,193 182,067 2012 2013 247
(i)(ii) (iii) 2012 2013 2014 12 31 630.2 703.2 713.6 20122013 (i)(ii) (iii) 2012 2013 20112012 2013 2014 (i) (ii) 2014 20122013 2014 12 3112,861 15,803 13,154 1,296 1,019 703 1,452 1,397 1,422 1,030 647 562 2012 2013 2014 12 31 5.6 7.4 6.5 0.9%1.1% 0.9% 248
12 31 2012 2013 2014.......... 419,207 67.1 480,384 69.0 446,018 63.1... 96,499 15.5 148,152 21.3 173,189 24.5......... 108,819 17.4 67,324 9.7 87,846 12.4......... 624,525 100.0 695,860 100.0 707,053 100.0 2012 2013 2014 12 31 7.8 17.6 29.4 (i)2013 12 (ii)v-drug 2012 2013 (iii) 2013 201312262014 12 31 2012 2013 2014............. 7,583 14,794 24,651........... 248 2,832 4,701 249
2012 2013 2014 12 31 110.0 105.4 132.9 2012 20132014123130.3 24.5 22.1 27.5%23.3% 16.7% 2012 2013 2013 2014 2012 2013 2014....................... 588,339,954 82,607 0.14 596,760,175 79,003 0.13 750,393,587 103,011 0.14......................... 38,589,642 20,731 0.54 38,562,199 20,440 0.53 40,124,754 21,311 0.53......................... 1,662,739 680 0.41 502,229 193 0.38 1,116,671 431 0.39.................. 10,024,260 5,361 0.53 9,918,336 4,746 0.48 16,004,100 7,776 0.49.............. 768,120 528 0.69 960,000 821 0.86.......... 1,635,900 129 0.08 5,153,200 171 0.03 5,980,480 395 0.07....................... 110,036 105,374 132,924 2012 2013 2014 12 31 582.6643.9 665.1 129.5150.4 182.1 18.2%18.9% 21.5% 250
12 31 2012 2013 2014........ 630,165 100.0% 703,245 100.0% 713,577 100.0%.... (568,548) (90.2)% (623,327) (88.6)% (623,317) (87.3)%........ 61,617 9.8% 79,918 11.4% 90,260 12.7%........ 7,831 100.0% 17,626 100.0% 29,352 100.0%.... (5,067) (64.7)% (12,211) (69.3)% (19,848) (67.6)%........ 2,764 35.3% 5,415 30.7% 9,504 32.4%........ 110,036 100.0% 105,374 100.0% 132,924 100.0%.... (41,319) (37.6)% (38,889) (36.9)% (50,300) (37.8)%........ 68,717 62.4% 66,485 63.1% 82,624 62.2% 201220132014 12 31 568.5623.3 623.320122013 20132014 2012 2013 2014 12 31 61.679.9 90.320122013 2014 12 31 9.8%11.4% 12.7%2012 2014 (i) (ii)2014 1 2012 2013 2014 12 31 251
5.1 12.2 19.8 2012 2013 2014 12 31 2.8 5.4 9.5 2012 2013 2014 12 31 35.3%30.7% 32.4%20122013 2013 V-drugChubu Yakuhin Co., Ltd.V-drug Chubu Yakuhin Co., Ltd. V-drug 2013 2014 201220132014 12 31 1.7 6.1 5.0 (i)(ii) 252
12 31 2012 2013 2014............ 4,921 2,662 35.1% (847) 9,935 4,859 32.8% (1,203) 16,546 8,105 32.9% (447)... 146 102 41.0% (869) 2,276 556 19.6% (4,946) 3,302 1,399 29.8% (4,520) 2012 2012 11 2012 (i) (ii) (A) (B)2013 2012 20132014 12 31 41.338.950.3 20122013(i)(ii) 20132014 253
2012 2013 2014 12 31 68.766.5 82.6 2012 2013 2014 12 31 62.4%63.1% 62.2%2012 201320132014 12 31 2012 2013 2014 (%) (%) (%)........... 52,206 63.2 49,235 62.3 63,108 61.3............. 13,994 67.5 14,805 72.4 16,061 75.4............. 267 39.2 68 35.2 140 32.5...... 2,441 45.5 1,861 39.2 3,331 42.8............. (249) (47.2) 555 67.6........ 58 45.2 (39) (22.9) (16) (4.1) 2012 2013 12 31 2014 2013 2014 12 31 2012 2013 2013 2014 2014 2014 254
2012 2013 2014 12 31 33.436.036.5 4.74.5% 4.3% 12 31 2012 2013 2014........................... 15,096 13,789 10,252........................... 5,832 6,658 6,218........................ 2,331 6,292 7,284............................. 6,052 4,394 5,607........................... 933 2,117 4,664...... 2,783 2,505 1,869.................. 227 60 85................................. 126 175 489................................. 33,380 35,990 36,468 255
2012 2013 2014 12 31 25.125.8 46.7 3.4%3.1% 5.5% 201212313.4%201312313.1% 20126.320132.7 2012 2013 20132012 2013 2013 12 313.1%2014 12 315.5%(i) (ii) (iii)(iv) (v) 256
12 31 2012 2013 2014........................... 8,178 9,794 13,197..... 1,400 3,557 1,093........................ 1,599 1,427 4,680........................... 1,954 1,677 4,912...................... 6,346 2,720 11,816.................. 1,886 1,924 3,283............................. 1,062 1,577 1,836...... 2,207 2,308 3,118................................. 505 795 2,794................................. 25,137 25,779 46,729 (i)(ii) 2012 257
12 31 2012 2013 2014........................... 6,955 10,884 13,812........................ 425 268 1,715............................. 965 1,418 1,317.................. 882 882 882 (1)............................... 1,152 1,160 2,946................................. 10,379 14,612 20,672 (1) (i)2014 (ii) 2012 (iii)(iv)(v) 2012 2013 12 31 0.4 33,000 2014 12 31 0.7 258
12 31 2012 2013 2014.......... (81) (32) (1,992).................. 392................. 43 (2).................... 1,239... 67 43 354 33 (710) 2012 2013 20132014 12 31 2012 2013 2014.................... 2,868 4,114 4,820........................... 49 1,293 3,642...................... 536 448 551................................. 3,453 5,855 9,013 259
2014 12 31 4.7 2014 12 312014 2014 12 31 4.7 2013 12 31 2013 12 31 A V-drugB AB2012 2 2012 2 2012 12 31 201251.9 2012 12 31 2013 12 31 2013 12 31 2013 16.1 2013 12 31 2014 12 31 2014 2014 12 31 33.2 260
12 31 2012 2013 2014........................... 26,418 81,312 71,869........................... 18,161 19,465 26,624.............. (1,051) (1,222) (884)........................... 17,110 18,243 25,740...................... 64.8% 22.4% 35.8%................ 15,361 18,579 22,550............................. 58.1% 22.8% 31.4% (1)................... 78,299 97,446 105,105...................... 19.6% 19.1% 21.5% (1) 261
2012 2013 2014 12 31 25% [2011]58 2011 1 1 2020 12 31 15% 2012 2013 2014 12 31 17.118.2 25.7 2012 20132014 12 31 64.8%22.4% 35.8% 2012 2014 2013 2012 2014 2013 2012 2013 2014 12 31 58.1%22.8% 31.4% 262
19.6% 19.1% 21.5% 40% 2011 12 23 201111 80% 20% 18% 2% 2014 12 31 2013 12 31 2013 12 31794.3 6.7% 2014 12 31 847.2 2013 12 31 703.2 1.5%2014 12 31 713.6 (i) (ii) 2014 263
2013 12 31 17.6 67.0% 2014 12 31 29.42014 2013 2013 12 26 20132013 12 2612 31 2014 2013 12 31 105.4 26.1% 2014 12 31 132.9 (i) (ii) 2013 12 31643.9 3.3% 2014 12 31 665.1 2013 12 31150.421.1% 2014 12 31 182.12013 12 31 18.9%2014 12 3121.5% 2013 12 312014 12 31 623.3 2013 12 31 79.9 13.0%2014 12 31 90.3 2013 12 31 11.4% 2014 12 3112.6% 264
2013 12 3112.2 62.3%2014 12 3119.8 2013 12 315.4 75.9%2014 12 31 9.5 2013 12 31 30.7% 2014 12 3132.4% 2013 12 31 38.9 29.3%2014 12 31 50.3 2013 12 3166.5 24.2% 2014 12 31 82.6 2013 12 31 63.1% 2014 12 3162.2% 2013123136.01.4% 2014 12 31 36.5(i) (ii) (iii)2013 2013 12 31 25.8 81.0%2014 12 31 46.7 (i) (ii) (iii) (iv) 265
(v) 2013 12 31 14.6 41.8%2014 12 31 20.7 (i) (ii) (iii) 2013 12 31 33,000 2014 12 31 0.7 (i) 2.01.2 2013 12 31103.3 15.0%2014 12 31 118.8 2013 12 31 13.0%2014 12 3114.0% 2013 12 315.952.5%2014 12 319.0 2014 12 31 4.7 2013 12 31 2013 12 31 2014 12 312014 12 31 2013 12 3116.1 106.2%2014 12 3133.2 266
2013 12 31 2014 12 31 2014 2014 12 31 33.2 2013 12 3181.3 11.6% 2014 12 31 71.9 2013 12 3118.2 41.1% 2014 12 31 25.7 2013 12 3163.1 26.9%2014 12 31 46.1 2013 12 31 7.9%2014 12 315.4% 2013 12 31 2012 12 31 2012 12 31712.111.5% 20131231794.3(i) (ii) 2012 12 31 630.2 11.6% 2013 12 31 703.2 (i) (ii)(iii) 20122013 2011 11 267
2012 12 31 7.8 2013 12 31 17.6 (i)(ii) (iii)v-drug 2012 12 31 110.0 4.2% 2013 12 31 105.4 2012 12 31582.610.5% 2013 12 31 643.9 2012 12 31129.516.1% 2013 12 31 150.4 2012 12 31 18.2% 2013 12 3118.9% 2012 12 31568.5 9.6%2013 12 31 623.3 2012 12 31 61.6 29.7%2013 12 31 79.9 2012 12 31 9.8% 2013 12 3111.4% 2012 12 315.1 2013 12 31 12.2 2012 12 312.8 2013 12 31 5.4 268
2012 12 31 35.3%2013 12 31 30.7%2013 2012123141.35.8% 2013 12 31 38.9(i) (ii) 2012 12 3168.7 3.2% 2013 12 31 66.5 2012 12 31 62.4% 2013 12 3163.1% 2012123133.47.8% 2013 12 31 36.0 (a)2013 (b)(i) (ii) (i) (ii)2012 9 2012 12 3125.1 2013 12 31 25.8 (i) (ii) 2012 2012 12 31 10.4 40.4% 2013 12 31 14.6 269
2012 12 31 0.4 2013 12 31 33,000 2012 0.4 2013 2012 12 3181.8 26.3%2013 12 31 103.3 2012 12 3111.5%2013 12 3113.0% 2012 12 313.569.6%2013 12 315.9 2012 2013 12 31 2012 12 3151.9 69.0%2013 12 3116.1 A B 2 012 2 2012 2 2012 12 31 2012 51.9 2012 12 31 2013 12 31 2013 12 31 201316.1 2012 12 3126.4 2013 12 31 81.3 2012 12 3117.1 6.4% 2013 12 31 18.2 270
201212319.3 2013 12 31 63.1 2012 12 31 1.3%2013 12 317.9% [ ] [ ] 12 31 2012 2013 2014............................ (42,242) 92,225 48,664............................ (2,698) (105,599) (16,294)......... 34,067 39,935 (30,933)............................ (10,873) 26,561 1,437................. 50,120 39,227 65,375....................... (20) (413) 247................. 39,227 65,375 67,059 271
2014 12 31 48.7 (i) 71.9 51.7 33.29.4 4.8 2.0 1.1 (ii)24.6 (A) (B) (C) (iii)13.0 2014 11 12 2013 2014 12 31 2013 12 31 (iv)10.3 2013 2013 12 31 (v)26.9 2013 12 3192.2 (i)81.327.5 16.1 4.1 3.8 12 3.1 (ii) 53.9 (iii)10.2 2013 62.2 2012 12 31 42.2 (i) 26.4 58.2 51.92.9 2.9 12 1.4 (ii) 21.0 (i)115.6 (ii) 11.8 2012 272
2014 12 31 16.3 (i) 19.8 (ii)20.2 (iii)9.9 (i)30.0 201330.0 (ii) 2.0 (iii)1.7 2013 12 31 105.6 (i)38.6 (ii)30.0 2013 12 100% 2014 3 (iii)20.0 HPV (iv) 10.5 (v) 10.0 (vi)9.9(vii)5.0 (i) 15.3 (ii)4.0 20132011 2012 12 31 2.7 (i)12.8 (ii) 3.9 (iii) 2.6 (iv) 2.520.0 273
2014 12 31 30.9 (i)100.0(ii)4.8 (iii)1.8 75.0 2013 12 31 39.9 80.0 (i) 29.0 (ii)8.6 (iii) 4.1 2012 12 31 34.1 (i)43.5 (ii) 24.0(i)30.9 (ii) 2.9 [ ] 12 274
12 31 4 30 2012 2013 2014 2015.............................. 67,876 58,817 69,128 92,059.......... 292,367 350,609 363,799 420,809................. 1,359 675..................... 92 247............... 17,702 2,385 340 340................... 15,382 53,977 74,180 24,893................. 39,227 65,375 67,059 8,152 432,646 532,769 575,181 546,253.......... (150,782) (208,966) (184,332) (149,315)......................... (24,000) (75,000) (50,000) (40,000)............... (173,560) (184,717) (220,355) (228,062)................. (8,511) (2,321)..................... (210) (210)............... (405) (2,029) (232) (232)......................... (12,797) (13,788) (13,472) (8,138) (370,055) (484,500) (468,601) (428,278)....................... 62,591 48,269 106,580 117,975 275
2012 12 3162.6 2013 12 3148.3(i)58.2 (ii)51.0(iii)15.2(iv) 9.1 58.2 8.5 2013 12 3148.3 2014 12 31 106.6 (i)25.0 (ii) 24.6(iii)20.2 (iv)13.2 (v)10.3 35.6 2014 12 31 0.2 2014 12 31 106.6 2015 4 30 118.0 (i) 57.0(ii)22.9 (iii) 35.0(i)58.9(ii) 49.3 276
12 31 2012 2013 2014............................. 145,577 155,919 218,563........................ 18,000 20,500......................... (7,464) (10,516) (9,254) 138,113 163,403 229,809........................ 3,140 389 5,507...................... 55,217 101,628 91,123......................... 95,897 85,189 37,360........................ 52,926 55,666............. 8,000................. 7,000 7,000 7,000............................ 6,500 2,500................. 89 109 109.......................... 7,900 3,200 (1).................. 2,033 2,093 20,686 (2)............................. 11,449 14,621 9,565 292,367 350,609 363,799 (1) (2) (i)(ii)(iii) (iv) 277
2012 12 31292.4 19.9% 2013 12 31 350.6 (i) 10.3 (ii) 2013 12 31 18.0 (iii)46.4 (A) (B) 2014 20132014 (i)10.7 (A)8.0 2012 (B) 4.7(C)2011 4.02013 4.0 3.2 2.7(ii) 2.8 2012 3.4 2014 7 (i) 20122014 7 2014 10 (ii) 278
100,000 100,000 201411(iii) (iv) (v) 2013 12 31350.6 3.8% 2014 12 31 363.8 (i)62.6 201411122013 2014123120131231 2014 2014 (ii)2.5 (iii)5.1 122014 12 2014 12 31 (i)47.8 (A) 201455.7 (B)(a) (b) 5.1 (C) 3.2 18.6 20142013(ii) 10.520142013 2014 12 31 2013 12 31 279
(i) (ii) 2011 11 2012 1 (i) (ii)(iii) 2014 12 31 1996 (i) (ii) 2014 6 12 31 2012 2013 2014 1.............................. 27,799 27,520 80,229 1 3............................. 31,756 31,706 98,686 4 6............................. 27,630 28,182 41,791 6............................ 50,928 75,995 9,103.................. 138,113 163,403 229,809 180 280
12 31 2012 2013 2014................................. 6,096 7,464 10,516...... 1,368 3,052 (1,239).................... (23)................................. 7,464 10,516 9,254 2012 12 311.4 2013 12 31 3.1 2014 12 31 1.2 281
12 31 2012 2013 2014...................... 74,702 80,288 206,119 1....................... 15,540 21,342 17,498 13........................ 12,266 25,332 3,722 46........................ 15,806 5,424 501 6....................... 19,799 31,017 1,969 63,411 83,115 23,690 138,113 163,403 229,809 201220132014 12 31 63.4 83.1 23.7 21.7%23.7% 6.5%30 2015 4 302014 12 31 16.971.3% 2015 4 30 2014 12 31 172.4 75% 282
12 31 2012 2013 2014 (1)......................... 64.9 69.3 84.7 (1) 2012 64.92013 69.3 201484.7 201220132014 12 31 45.2 40.0 66.6 2012 2013 2012 2013 20142014 11122013 2014 12 31 2013 12 31 201220132014 12 31 2.514.0 12.2 2012 2013 20132014 201220132014 12 31 160.6 253.0 179.7 283
2011 11 2012 2013 2014 12 31 103.4 182.3 124.7 2012 103.4 2013 182.3 90 90 180 2013 2014 (i)(ii)(iii) 2013 12 31 46.4 39.8 2014 12 31 2012 12 31 67.9 13.4% 2013 12 31 58.82013 2013 12 31 58.8 17.5% 2014 12 31 69.12013 12 31 2012 2013 2014............................... 5,102 3,590 2,667............................... 1,040 748 404............................... 61,717 54,462 66,040............................... 17 17 17................................. 67,876 58,817 69,128 284
2012 2013 2014 12 31 40.2 35.935.1201240.2 2013 35.9 20132012 12 31 2013 12 31 13.3%2014 35.1 (i)2013 (ii) 2012 2013 2014 12 31 34.5 30.0 30.5 2012 2013 2013 2014 201220132014 12 31 216.3 195.1 136.1 201220132014 12 31 65.3 52.2 29.5 2012 2014 12 31 2012 2013 2014 (1)....................... 40.2 35.9 35.1 (1) 2015 4 30 2014 12 31 58.5 84.6% 285
12 31 2012 2013 2014............................. 57,285 52,692 28,617............................. 60,797 122,558 107,524........................ 7,469 8,840 16,337................ 7,482 9,637 9,120 (1)....................... 2,088 6,663 8,080.................... 6,500.............. 9,161 8,576 14,654 150,782 208,966 184,332 (1) 2012 12 31 150.8 38.6% 2013 12 31 209.0 (i)61.8 (ii)4.6 (iii)2.2 (iv)1.4 6.5 2013 4.6 2013 20120.6 2013 12 31209.0 11.8% 2014 12 31 184.3 (i) 24.1 15.0 (ii) (i) 7.5 (ii)(a)(b) 6.1 (iii)(iv) 286