( ) (Nakashima et al., 1995; Davies et al., 1998; Morioka et al., 1993; Gehrmann et al., 1992) (Selman et al., 1980) (barbiturate) (Selman et al., 1980) (steroids) (lysosomal enzyme) (Anderson et al., 1979) (Smith et al., 1972) (hyperbaric oxygen) (Chang et al., 2000; Rocksword et al., 2001; M. Krakovsky et al., 1998; Nighoghossian et al., 1995; James et al., 1987; 1
Richard et al., 1980, Kawamura et al., 1990) (neurons) 15% (glia cells) 85% (astrocyte > 80% ) (oligodendrocyte < 5% ) (microglia 12-15% ) (Perry et al., 1988, Lawson et al., 1990) 2
(BBB blood-brain-barrier) (myelin formation) (scavenger cell) (Giulian, 1987; Hertz et al., 1990) (Wang et al., 2002) (cytokine) (Kim, 1995; Matsumoto et al., 1997) (Kim, 1996, Feuerstein et al., 1997) (Grau et al.,1992) (Davis et al., 1994) (Ulvestad et al., 1994) Rio Hortega (Davis et al., 1994) 3
12-15% (Glenn et al.,1992; Streit et al.,1989) (ramified microglia) 5-10 (Boya et al., 1991; Perry et al., 1988; Streit et al., 1987; Suzuki et al., 1988) ( ) (amoeboid microglia) (Ashwell et al., 1989; Giulian et al., 1986; Hume et al., 1983; Perry et al., 1988) (, ) (reactive microglia) (brain macrophage) (Boya et al., 1987, 1991; Perry et al., 1988, Kato et al., 1996) (amoeboid microglia) 4
(Giulian et al., 1986; Hume et al., 1983; Perry et al., 1988) Aldskogius (1. (axotomized neuron) 2. 3. ) Xu Nakashima (NOS) Clark Hayashi CA-1 Morioka 5
(major histocompatibility class II molecules, MHC class II, OX6) Davies Kato OX42 OX42 Chen 1986 6
18% 7% Bederson TTC (2, 3, 5 - Triphenyltetrazolium chlorides stain) 1992 Menzies Buchan Chen 20.94% 78.08% 0.04% hyperbaric oxygen HBO 100% Grim et al., 1990 1.4 3ATA 4ATA 7
3ATA (Huang et al.,2000, Chavko et al., 1998) Freeman et al., 1982 ATA atm atm ATA atm 1 atm 2 ATA, Whalen Heymanm 1966 3ATA 2.4-3 ATA (UHMS, Undersea and hyperbaric medicine society) : ( ) (Decompression sickness, DCS) ( ) (air embolism) ( ) (intracranial abscess) ( ) (chronic osteomyelitis) 8
( ) (thermal burns) ( ) (chronic skin ulcer) ( ) (carbon monoxide poisoning) ( ) (problem wounds) ( ) (exceptional blood loss and anemia) ( ) (crush injury and compartment syndrome) ( ) (skin grafts and flap) ( ) ( necrotizing soft tissue infections) ( ) (including soft and bone necrosis) (Richard et al., 1980; James et al., 1987; Krakovsky et al., 1998; Nighoghossian et al., 1995; Kawamura et al., 1990; Chang et al., 2000; Rocksword et al., 2001) (Mink et al., 1995; Demchenko et al., 2000; Rockswold et al., 2000; Kawamura et al., 1990) (Marx RE et al., 1990) (Leach et al., 1998) (Torbati et al., 1984) (Rockswold et al., 2001) 9
( Raphael et al., 1989) 20% (Velkamp et al., 2000; Sunami et al., 2000) ( Chang et al., 2000) (Huang et al., 2000) (Chavko et al., 1998) 2000 Chang 2001 Badr ( ) ( ) 1979 Bokeriia 1980 10
Hansbrough 2.5 ATA 1991 Saito B T 1993 Thom 1996 Chen 2 interin ICAM-1 (intercellular adhesion molecule-1) (Inamoto et al., 1991) ( ) ( ) 11