306 : 1000-1336(2009)03-0306-09 ( 200031) Q53 ABO(H) [3] Landsteiner ABO O A B AB 4 N- - L- H O N- N- A B [1] (Glycoimmunology) A B 4 [2] / 1.1-2009-03-09 ( 1 9 4 0 - ) ( ) E - m a i l : keyiwang0717@gmail.com A B A B AB O A B AB A B O
( ) 307 A B B B B ABO LeA LeX LeB LeY 1.3 ABO ABO O Rh O α -1, 3 [6] [ 4] ABO ABO (marginal zone) T [7] 1.2 1.4 [8] ( ) [ 5] 1.5 -
308 [9] (Ritsumeikan) (GlycoEpitope) (http://www.glyco.is.ritsumei.ac.jp/ epitope) 1.6 CD1 2.1 T(natural killer T NKT) CD1 B I (MHC) b 2 MHC-I CD1 (MBL) 5 CD1 CD1a-CD1e MBL CD1d NKT C 2 T a b T III [12] MBL (TCR) C1 TCR CD1 1a [10,11] ( 3) CD1 MBL ( 1 b-d) CD1 TCR (CDR) C CD1- -TCR C (CTLD) L- / F- [12] F- MBL - 2.2
( ) 309 C 2 CRD [12] 2 MR (MR) C 2 VI B T 8 C (CRD)
310 MR N CRD b1-3 R( ) (dectin) [13] C b1-3 C CRD CD-SIGN II MR DC-SIGN
( ) 311 (pattern recognition receptor, PRR) toll (TLR) 10 [14] C TLR-1 TLR-2 TLR-3 TLR-4 RNA TLR-5 TLR-7 A (PHA) RNA TLR-9 DNA TLR-9 DNA TLR-4 3.1 C I 2.3 CD22 B C I [I/V/L/S]-X-Y-X-X-[L/V]- (ITIM) C 2 II V [15] B CD72 B 4 C
312 (dectin)1 5 [16] (ITAM) ITIM ITAM C T (NK) LY49 3.3 T 3.2 I T (TCR) N- V T T B (BCR) CD22(I [17] ( 6) N- ) BCR CD22 2- TCR 6 - CD22 3.4 CD22 BCR
( ) 313 [16] 1 2003 [18]
314 [1] Alavi A et al. Advances in experimental medicine and biology, New York: Plenum Press, 1995, vol.376, Glycoimmunology [2] Bishop JR et al. Glycobiology, 2007, 17: 23R-34R [3] Schenkel-Brunner H. In: Kamerling JP. eds. Comprehensive 3, 343-372, Elsevier Science [4] Galili U. In: Kamerling JP. eds. Comprehensive Glycoscience: from Chemistry to Systems Biology, 2007, vol. 3, 225-236, Elsevier Science [5] Jefferis R. In: Kamerling JP. eds. Comprehensive Glycoscience: from Chemistry to Systems Biology, 2007, vol. 3, 373-392, Elsevier Science [6] Blixt O et al. Glycoconj J, 2008, 25: 27-36 [7] Salehen N et al. Vaccine, 2008, 26: 451-459 [8] Yamada H et al. In: Kamerling JP. eds. Comprehensive 4, 663-694, Elsevier Science [9] Satoh M et al. In: Kamerling JP. eds. Comprehensive 4, 643-662, Elsevier Science [10] Zajonc DM et al. Curr Opin Struct Biol, 2007, 17: 521-529 [11] Seino K-i et al. In: Kamerling JP. eds. Comprehensive 4, 9-16, Elsevier Science [12] Vasta GR et al. In: Kamerling JP. eds. Comprehensive 4, 17-35, Elsevier Science [13] Adachi Y et al. Infection Immunity, 2004, 72: 4159-4171 [14] Akira S et al. Cell, 2006, 104: 783-801 [15] Nitschke L et al. Trends Immunol, 2004, 25: 543-550 [16] Marth JD et al. Nat Rev Immunity, 2008, 8: 874-887 [17] Bianco GA et al. Autoimmunity Reviews, 2006, 5: 349-356 [18] Wong SYC et al. Immunobiology of Carbohydrates, New York: Kluwer Academic/Plenum Publishers, 2003, Glycoimmunology Ke-Yi WANG (Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China) Abstract The relationship between carbohydrate and immunology is very close. In this paper these relations were discussed from three aspects: carbohydrate antigen and anticarbohydrate antibody, innate immunity and adaptive immunity. Key words carbohydrate antigen; anticarbohydrate antibody; innate immunity; adaptive immunity