( )

1,,, 13, 314,,,,,, ( ),,,,, 80,,,,, ;,,,,,,, ;,, ;,,,,, 1997 11 16

1 ), ( ),,,,,,,,,,,,,,, 1. 33 ; ; ; ;, 25, 10, 33 1 2. 21, 30g, 35, 31, 4, 88. 57% 2 3. 1 1 30g, 12, 3, 8 3 4. 1 78,,,, 30g, 12g, 9 4 15g, 1 3 3, 7, 22. 7/ 14. 7kPa 18. 7/ 12kPa, 1, 5 5. 1, 24g, 10g, 15 g, 10g, 10g 3,, 20,, 11 6 3, ; ; ;, 3 7 15g, 10g, 20g 1 X,, 3, 8, 24, 4, 11, 6, 3, 62. 5%, 87. 5 % 15, 6 2 9 6. 120 X

2 18, 2 1520g, 1215 g 74, 12g, 20g, 10 g; 14, 10g, 12g, 15g; 26, 10g, 15g; 6, 10g, 20g, 4, 116, 96. 67 %, 69. 17 %,,, 84. 62%, 15. 38 %,,, 10, 30g, 15 g, 6g, 30g 1, 5,,, 6 50, 30g, 20g 20g, 15g, 10g, 5g; 15g, 20g; 10g, 15g; 15g, 10g, 15g1, 3 25, 19, 6, 88% 15, 45, 26 11,, 30g, 15g, 15g, 20g 2, 5,, 2 12 35, 1565, 45, 22, 13 13 7. 20g, 5g, 10g 1,, 30 6 8. 1,,, : 250 g, 50g, 15g, 12g 2, 14 4, 1030, 1 5, 22, 18, 4,, 16 9. 36, 6090g, 1530g ;, ; ; ; ; ; ; 1,, 5 1 : 26, 8, 2, 94. 4% 1 7 1 50g, 20g, 10g, 7g, 10g 4,, 20 2 1 2 10.,, 15g,,, 1020, 18 11., 1, 50 g, 15g, 1, 2 1 9 12. 97 30g, 6g ; ; ; ; 69, 26 ; 2, 97. 7% 20, 1 30, ; 4, 80% 21

3 3. 40 ; 2, 1000ml; 27. 5g, 1,, 3 35, 5 22 14., 60 g, 15g, 10 g 6 30g, 15g, 1, 4,, 10 2 19 60 2432 g; 1015g: 915 g; 915g; 10 g; 2030g 24,, 1 1 7, 2 2 3 ; 1830 g; 1530g; 1520g, 1,,, 2 4 1,,,,,,,, 25 15. 30 g, 10g, 15g,, 5 5 5g, 3g 69 ; ; ; : 2 58, 4 10, 1 26 16. ( ),, 23, 10, 2,,, 27 17.,, 1,,,,,, 9, 28 18. 1,,,,,,,,, 30g, 15g, 4, 28 19. 1, X 60g, 15g 12g, 18g, 2,,, 3 2 3 9 20. 1 10,, 4,,,, 19 3 0 21., +, 18g, 6g, 6g, 6g, 5,,,,, 12 3 1 22., B,

4 60g, 15g, 1 2, 1, 2, 3 2 1,, B 3 2 10g, 15g 1, 3,, 33,, 11, 4,,, 3 4 23. 8, ; 19, 35 24., 27,, 17 35 1,,,, 6 36 25. 120, 72. 5% 94, 71. 4 %, ;, 3 7 26., 60g, 15 g, 30g, 30g 6,, 10 38 21, 30 g, 15g, 30g; 10g, 30g; 30, 6g, 625,, 2, 39 54, 11, : 48, 6 40 1 7,10 1, 5, 1, 1 41 10mg, 3 2, 710, 12 4 2 27. 10 g 1 2, 15g, 2 30, 15g 1, 4 4 3 3, 30g, 15g, 3 ; 30g, 12 g, 10g, 3 ; 30g, 15g, 12g, 10g, 4 35 44 28. 20g, 10g 42 7 25, 1 30, 12, 4 5 10g, 15g, 5g 1, 4, 3,,, 8 3 3 29. 11, 15g, 11 4 6 30. 1, 45g, 15 g, 30g, 12g 16, 5

5 23,, 6090g, ( ) 1030g, 20 40g, 1030g, 1530g, 1020g, 12 g, 1218g, 10g, 1 15, 7, 1 47 50g, 20 g 20g, 30g 1 3 6,, 12, 24 48 60g, 15g, 9g, 1, 2 38, 8, 4 530 3, 49 8, 3 4,1 8 5 0 1 60g, 15g, 1,, 6, 32 31., 5 1 32. 3060g, 10g, 4060, 3 10 30, 16, 9, 5 52 2 46 5 3 33. 24g, 12g, 4 1 54 5 5, 85, 15g, 10g 35,, 28,,,3 50%,,, 1 15% 5 6 30g, 15g, 9g, 3g, 4. 5g 1, 30,, 5, 30 15g, 30g, 12 g 1, 6, 2 57 34., 10 310 5, 1020 5 58 35. 3060g, 1015g, 1 32, ;, ; ; 32 2. 2, 6 59,, 60 6g/ 4, 3, 1 61 36. 7 1,,,, :

6 4g, 5g, 12g, 30g, 6g 16, 8 57 30g, 15g 1, 3,, 10, 62 37. 1,,,,,,,, 1,, 62 1. 1, 20,, X, 20g,, 18,, 22 X,,, 63 1, 10,, : 40 g, 20 30,, X,,, 1 64 2. 1,,,,,, ( 24g, 12g) 4 54 3. 10 g, 15g, 6g 1, 1,, 300mg, 2, 2 30, 33 : 30 g, 15g, 9g, 3g 1 1, 1 65 4. 15g 1, 16,, 3 3 15 g, 30g, 10g, 1, 15,, 6 6 5. 30, 10, 19, 1 20g,, ;,,, ;, ;, ; ; ; 19, 10, 1, 24,, 6 7 56g, 10, 1472, 3 68 1, 3, 1. 20. 8cm 1, 6 9 6. 6g 32,,,, 1, 3, 70 30g, 15g, 20g, 10 g 81, 10g, 4g, 10g81 15, 5 50, 40, 7,

7, 94% 71 7. 1,,, 5, 7, 14, 7 2 8., 30 g, 15g, 10g 2, 4,, 30g, 15g, 6g, 10g,, 4 73 9. 25g, 30g, 12g 10 1, 4, 5 ; 2, 4, 4 74 10. 10g, 12g, 6g,, 10 54 11. 1,, 3,,, 2,, X, 5 4 12. 12g, 15g 150 ( 85, 60, 15 ) 12g; 12g; 12g; 15g, 12g 109, 42, 9 : 4 6 60, 58, 1, 1, 96. 7% 75 1. 30g, 15g, 10g 1, 2,,, 3 76 43, 1 16, 30g; 28, 10g 23 23, 6, 17 17, 17, 6, 4 1,,, ( P < 0. 01 ), 21 28, 18, 3 77 10g 16,, 3 2,, 16 14, 2 78 2, 34, 7 9 2. 3 1,,, 2,,,, 8 0 3. 8 1,,,, ( 45g, 20g) 1,, 4, 8 1 4. 49,

8. 5, 3 : 2, 7, 8 2 110 7. 5g, 1018 1, : 42%, 18% ; 6 ( P < 0. 05), E2 6 ( P < 0. 05),, ;, E2 ;, 8 3 5, 4, 1, 84 1. 13 11, 2, 1632 7. 510 g/ 2 1, 4, 4, 4 2, 8 5 2. 30g 1,, 4, 86 3. 1,, 50, 2, 11,, 5, 8 7,,, ; ; ; ; ; ;,,, E 2,, ; 45 Ca, 45 Ca, 1. (11 ),,,, 88,, 89,, ;,, ; 3H-QNB,,, 90,,,, 9 1, 92 48%, 35%, 9 %, 93

9 4, 41, ; 95 2. :,,, 91 Ca, Ca 9 6 3.,, camp, cgmp,, 97 4. (PRL ) 78, 0. 7mg/ ml, 7. 5g/ 1018, 6, ( E2 ), 10 2 PR L ( P < 0. 05 ), 6,, PRL,,3 24, PRL 98 RPL 99 5. (T ) 110, 6, T, E2 ( P < 0. 05 ),,, 83 100 101 11988, (1 ) : 48 21981, (9 ) : 66 31986, (1 ) : 44 41986, (4 ) : 4 5 1985, (4 ) : 36 6 1984, (4 ) : 71986, (6 ) : 20 8 1986, (9 ) : 25 9 1980, (4 ) : 3638 101984, ( 2) :22 111995, ( 7) :15 121994, ( 6) :38 131990, ( 11 ) : 20 141993, ( 9) :47 15() () 1987, ( 3) :53 161982, ( 1) :22 171995, ( 4) :10

10 81994, ( 2) :23 191994, ( 6) :40 201992, ( 10 ) : 16 211994, ( 5) :195 221995, ( 1) :23 231983, ( 8) :79 241982, ( 1) :52 25 1980, ( 2) :75356 261980, ( 8) :356 271983, ( 4) :29 281983, ( 4) :29 291986, ( 4) :41 301981, ( 6) :21 31 1988, ( 6) :35 32 1995, ( 4) :55 331986, ( 8) :11 34() ( ) 1980, ( 2) :39 351980, ( 1) :50 36 1985, ( 11 ) : 55 371981, ( 6) :46 381987, ( 2) :43 391986, ( 2) :17 40 1984, ( 3) :29 411987, ( 5) :12 42 1985, ( 3) : 431987, ( 6) :258 441985, ( 11 ) : 36 451983, ( 11 ) : 9 46 1980, ( 9) :40 471982, ( 7) :45 481986, ( 3) :30 49 1992, ( 1) :8 501993, ( 5) :127 511985, ( 4) :6 52 1995, ( 1) :21 531984, ( 9) :30 541982, ( 4) :181 55 1988, ( 6) :39 561985, ( 6) :50 571989, ( 10 ) : 20

11 81986, ( 6) :35 591991, ( 1) :20 60 1991, ( 6) :54 61 1994, ( 4) :294 621983, ( 6) :4 63 1981, ( 4) :29 64 1984, ( 2) :34 65 1983, ( 10 ) : 462 66 1987, ( 4) :25 671986, ( 3) :29 68 () () 1981, ( 2) :51 69() () 1980, ( 2) :39 70 1986, ( 3) :26 711987, ( 6) :48 721984, ( 4) :188 73 1994, ( 4) :179 74 1984, ( 8) :494 75 1980, ( 1) :18 761993, ( 6) :278 77 1988, ( 6) :16 781983, ( 1) :33 79 1989, ( 1) :46 80 1986, ( 1) :46 811986, ( 4) :43 821990, ( 3) :486 83 () () 1988, ( 4) :50 84() () 1991, ( 4) :40 851989, ( 3) :51 861983, ( 6) :43 871987, ( 1) :19 88 1991, ( 7) :407 89 () 1981, ( 5) :46 90() () 1984, ( 1) :58 91() () 1987, ( 1) :57 921991, ( 1) :45 931985, ( 11 ) : 513 94 1980, ( 9) :36 95() () 1983, ( 6) :21 96 1991, ( 7) :45 971985, ( 4) :36

12 8 () () 1988, ( 2) :18 99 () () 1988, ( 2) :44 100( ) ( )1988, (2 ) : 48 101 ( ) ( )1988, (4 ) : 45

13 ), ( ),,, (),, (, ),,,,,,,, :,,, :,,,,, ;, ;, ;,, ;,, ( ), (, ), ( ),, 1., 20, 1520, 18. 6, 510, : 27 ( 38. 6 % ), 19 (27. 1% ), 16 ( 22. 9 % ), 8, 88. 6% 1 30, 11, 7, 11, 1, 96. 7 % 2 15g, 9g, 0. 01g( ),, 1, 1 3 1, 6g, 12g, 15g5,, 30g, 6, 4 7 1 15g, 9g, 24 g, 3g, 9g, 9g, 6g, 9g, 7, 6 g5 5 1, 9g 7 6 1,, 3,, 15, 7,, 8 9,, 10, 2. 10g, 12g, 1 12,, ; 10g, 12, 11 3., 2 :1, ; 1

14 1, 50g, 18 g, 12g, ( )10g, 1 6, 4, 2, 1, 1 2 4. 1 10, 2,, :, 32 / ; ; 2 58 /,,, 1, 200ml,, 10,,, 70 / 10g,, 1,,7,,, 60 /,,, 1 3 5. 30g, 12g, 1 8, 22. 5/ 14. 5kPa 19/ 11. 5kPa,,, 1, 1 0 6. 1 7 5, 30g, 25,,,,, 6 7., 1, 1 4 1 20,, 10, 1 5 8. 15g, 45g, 9g, 30g, 6g, 1 10, 3 9. 1, 24 16 10.,,,,,,,,,, : 15g, 6g, 6g, 10g, 12g, 15g, 12g, 12g, 3g, 12g, 6 g11, 17,,,,, 1 7 11. 10g, 1 6, 3, 3, 18 12. 1 1,,, ( ), 4,,, 5kg9g, 6g, 30 g, 15g, 15g, 10, 10g, 1,, 19 9g, 6g, 9g( ), 15g,, 1 30,,,, 5 2 1 5,, 20,, 2 2 0 30g,

15 5g, ( )1 12,,, 48 10 10g, 50g, 15g,, 1 10, 10,, 3 21 13. 1, 8 2 2 14. ( ), 6g, 9g, 15g, 20g, 1 7,, 2, 23 9g, 24g, 1, 40 24 50,,1 1,, 4 1 2, 2 (, 2 ) 25 ; ( 2 ) 18, ( ) 7 86 % 25 37, 10g,,, 2 10, 18, 9 60150 26 9 8, 1 1, 6g 90 g,, 30, 20 2 7 4, 6g, 3g, 2g, 6g, 2g1,, 20, 1 28 1 4, 29, 30, 31, 32, ;,,, ;,,,,, 15. 6g ( ), 50g, 1, 18 6, 10g, 20g, 1 3,,,, 20 31,, 1, 14 10 4 15g, 3g, 24g, 1, 20 24, : 15g, 30g, 12g, 6g, 3, 10 g1, 2 34 1 ;, 5 4,, 21 1 5,, 3 20 30 :, 12 g; 20g; 9g, 30g; 30g, 12g, 20g; 20g;, 12g, 15g;

16,, 2,10 1 : 20, 6, 4 3 5 62 : 55, 3, 3, 1 : 1530g, 1015g, 1013g, 3 5g, 510g1, 2,, 5, 2 36, ( ) 6g, 20 : 18 ; 2 3 7 16. 10 1, 10 g, 9g, 3, 12 15 1 23 38 1, 5,,, 20ml/ 39 15 g, 10g, 3g, 1, 40,, 24 14, 12g, 30g, 20g, 1, 50, ( - ) 4, ; ; 4 0 17. 1 18,, O 3 8 18. 1,,,,, 41 1 54,, 20 8,, 20, 42 60g 1 2,, 8,, 30g, 5, 38 30g, 15g, 1 8,,,, 8 38 19. 1 : 30g, 20g, 10g, 45g, 5g, 5 15,, 60g, 45g, 15g, 15 g, 50,, 4 2 20. 10g, 3 1 10,, 20,, 15 21. 1,,,,,, 6, 43 22., 30g, 20g, 6g, 6g, 15g, 1 20 4 () 1, 5,

17 2,, 44 1 2,, 3, 1 4 50, 100%, 86%, 60 % 45 23.,,,,,, 15g, 10g, 10g, 6g, 5, 6 1 2 24. 1,,, 43 25.,,,,,,,,,15, 1 46 26. 21, : ; ; ;, 1, 5 : 19, 2 47 1 15 g, 6g, 10g, ( )5g, 8,, 1,, 3 48 1 16,,, 3 12 27. 1 20,,,,,,, 15g, 10g, 6g, 3g 3 15 1,, 10 5 4 9 28., 14 29. 1 1,,, : GP T340, T T T : 10, Zn T T : ( + ), : 20g, 10g, 6g, 30g, 3g, 12, 9g 20,,, 48 30. 1,,,,,,, 20g, 15g, 15 g, 6g, 10 g, 4. 5g, 10 g, 10g, 15 g, 15g, 10 15,,,, 10, 5 0 31. 8g, 10 g, 6g, 10 g, 12g,, 1,,, 8, 1 2

18. 1 8 50, 10,, 10g, 6g, ( ) 4g, 15g, 5g, 12, 9g3, 3 48 2. 6g, 9g, 3g, 1, 51 3. 1 1,,, : 12g, 3g, 10g, 15g, 30g, 15g, 12g, 9g, 6 g3,, 10g, 24, 52 4. 10g, 15g, 9g, 1, 1, 3 3 48 108 30g, 8g, 10g, 5 g, 15g, 1015g1, 800ml, 300 ml, 6, 5 1, 23 : ( 1,, 3 ) 63 ; 41, 4, 96. 3% 53 35 2,, 1 :20 (,, ) 57. 1%, 13 (,, ) 37. 1%, 2 (, ) 5. 7% 94. 2 % 54 5. 9g, 4. 5g, 1. 5g,, 1, 6.,, 1 6g, 10g, 30g, 21, 5 5 7. 10g, 9g, 6g, 1 7, 14 56 12 g, 10g, 1 3 21 1 ( 2 3 ) 2, 41 3g, 9g, 4. 5 g,, 1,2 8 1,,,7. 5 g/, 7. 5g/, 2,,, 2 57 8. ( )1, 5, 20,,,,, 2 20

19, 20,, 15 14 33 : 22, 10, 1 58,, 10 : 9, 1, 5 9 10g, 15g, 12g, 12 30 g,, 15 : 13, 1, 1 60 9. 3g, 30g, 1,, 22. 7/ 17. 3kPa 14. 7/ 10. 7kPa 5 2 10. 1,3 1 4,, 4 11. 80 : 15g, 30g, 6g, 3g, 10g1,, 2, 15 1 : 41, 20, 12, 7 1, 4 6 1, 1,, 1,,, 6 2 12. 238 203,,, : ; ; ; ;, ;, 20 1 : 96 56 ; 119 89 ; 19 38 ; 4 20 ; 12 33 90. 33% 71. 42% ( P < 0. 05 ), 5. 58% 22. 75% ( P < 0. 05 ) 63 13. 7,,, 1, 1, 2, 4,,, 6 4 14.,,,, 1,, 3,,, X :, 3,, 62 1,, 10,,, 2,, X : 10, 65 15.,,, 1. 5,,, 4,,

20, 1,, 3, X :,, 6 2 16. ( ) 20 : 15g, 12g, 10g, 8g, 3g( ) 18g, 30g, 15 g, 15 1 1 8 2 12 : 10, 8, 2,, 15g, 57,,, 2 66 32, 30, 1, 1 : 1, 12 1 13 67, 3, ( ( 10g, 3g), 33 : 17, 6, 10 6 8, 30g, 10g, 6g, 3 1, 20 1 2 10g, 1, 2 3 3 1 : 9g, 4. 5g, 6g, 6g, 6g, 9g, 15g, 9g14, 5,,,, 6 6 2 17. 24, ;, 12, 11, 1 69 18., 30 g, 15g 1, 4, 6g, 14 3 18 19. 1 4 39 20.,, 3g, 9 g, 3, 1, 70 21. 1 33cm,,,,,, 10g, 3g3,,,, 6, 71 22. 50 50 18, 15, 10, 7 ; ; ; 1 600ml, 150ml, 6 1 : (3, ) 18, 24, 8, 84% 7 2 23.,,,,,,, 15g, 1,,, 10,, 73

21.,, 6g, 7 5 2. 1 2, 2, 35 35, 2, 1, 2 0 12 g, 21g, 6g, 1, 5, 3, 74 12g, 9g, 1, 6 2, 6, 4. 5g, 12g, 15g, 1 10, 2, 30 1 3 15g, 10g,, 1, 3, 3, 1, 7 5 30g, 15g, 10g, 15g, 10g, 1, 2,, 5, 2, 7 6 1 : 20g, 6g, 6g, 12g, 15g, 12g, 15g, 25g 2 34, 2 4,, 10g, 4. 5g, ( ) 20 g, 3 5,, 10, 1 5, 1 4 1,, 3,, 12 3, 4 6 3. 1 : 12g, 10g, 15g, (), 6g, 7g, 9g, 20g6,,,,, 2 5 3,, 7 7, 4 1,,, 1, 2 2,, 44 10g, 1 6,,, 3, 7 8 3g, 9g, 1. 5g, 3, 1 4,, 8 4. 15g, 15g, 10g, 15g, 10 g, 15g 1 20, 2 3, 2, 4 24, 76 5. 15g, 12 g, ( ) 10g, 9g, 1, 9 78 6. 10, 2, 4, 2 : 10g, 15g, 30g,

22 g, 3g30g; 8 4 15g 1 15 1 79 7. 12g, 1 1, 1 8 0 8. 76, : 12g, 18g, 9g, 3g, 6g, 15g, 30g, 24g, 3 : ; ; ; ; ; ; 1, 10 1 : 52, 20, 4, 94. 7 % 10, 30, 7, 8 1 9., ; 49, 7. 5g, 3 24, : 49 8 3, 38, 4 ( 10. 5 % ), 23 ( 60. 6% ), 7 ( 18. 4 % ), 4 (10. 5% ), ( ) 71. 1%, : 40, 82 10., 1, 9, 5, 2 2 9g, 12g, 1 4, 2, 1, 4, 3,, 1 78, 2, 8 3 1 3, 3, 3,,, 20, 3 3, 15g 6 1,, 9,,, 3 1, 2, 18 9g, () 1 3 74 11. 6g, 9 g, 12g, 3,,, 1 2, 6, 15g, 2, 84 9g, 30g, 12 g, 1,,,, 3,,, 10 12. 30g, 15g, 30g, 15g 1 4,,,, 4,, ; 8 5

23 3. 3,,,, 10g, 9g, 1, 2, 41 14. 52,, : ; ; ; 7, 1, 2 7 1, 30 1 : 28 ( 1 ) ; 24 ( 1, ) 86 15. 1, 3,,, 9g, 500ml, 30ml, 1,, 1 3, 10ml, 30g7,,, 30, 2,,, 10, 6 5, 87 8 8 1. : 10g, 5g, 6g, 3g,, 1 3 1,, 2, 1, 8 9 6g, 4g, 3g, 3, 1 13, 90 2. 4 g, 5g, 9g, 1 13 1, 6 5,, 56 3. 9g, 10g, 12g 1 8,, 10,, 5,, 5 6 4. 4,,, 10g, 1, 4, 14,, 2 56 1. 15g, 12g, ( )1 3 91,,, 1 1,,,,, 41,,, 92

24. 30g, 10g 1, 3, 45, 1. 0 ( ), 93 3. 15g, 9g, 6g, 30g, 12g, 1 4,, 24 10, 9 4 1. 1, 3,, 6, 8 95, 1 6 4 12g, 10g, 6g, 15g 1 6, 6 1 12, ; 1, 12,, 46 1,, 10 3 0 1 1, 1, 4 4 30g, 10g, 3, ( ) 1, 3,, 21, 1 8 10g, 23 : 11, 6, 6 9 6 97 2. 10g, 30g, 7 98 12g, 10g, ( ) 20g, 1 3, 6 9 5 3. 10g 1 8,, 4,, 3 95 4. 30g, 15g, 10g, 1,, 14 18, 3g, 15g, 1, 12 30 10g, 15g, 50 g, 5 1 5, 15, 21 5. 30g, 15g 1,, 6, 10 g, 5 2 1, 2 95 6. 4 2 7. ( ) 2, 99 8. 12g, 9g, 30g, 15g, 1 15,, 6 / mm 3 1117 / mm 3 11

25. 79 : 20g, 10 g, 6g; ; ; ; 1, ; : 34, 23, 11, 86. 1% 57 2, 6, 1 00 10. 4 4,, 250ml, 3, 4 36 101 11.,,, 10g, 1520, 2, 100 68 10 2 54,, 1 2, 7 1, 1 4 4 85. 20%, 100%, 103 6g, 30g,, 2,56 10 4 1, 2,,4 39 6g, 10g, 1 6, ( ),, 7 6, : 9g, 9g, 6g, 9g, 6g, 6g, 15g 20, 5, 10g, 15g, 6g, 1, 8 3 0 1. 15g, 5g, 4g, 10 g, 1,,, 4, 10, 73 2. 20 g, 10g 1,, 2,, 15g, 20g, 5, 9 4g, 10g, 5g, 1 3, 7 3 3. 6g, 10g, 5, 1,,, 1, 2 15 1.,,,,,, 1,, 105 2., 3.,

26,,,,,,, 1 06 1 1981, 61 (1 ) : 57 2 1985, (6 ) : 25 31980, (6 ) : 13 41988, (2 ) : 4546 5 1988, (1 ) : 35 61988, (3 ) : 13 7 1978, (4 ) : 34 81965, (2 ) : 7 9 1986, (3 ) : 47 101981,2 (2 ) : 33 11 1984, ( 1) :26 12 1990, ( 3) :21 13 1993, ( 11 ) : 51 141984, ( 2) :69 151987, ( 2) :34 16 1986, ( 12 ) : 53 171988, ( 2) :49 181983,18( 4) :185 191987, ( 6) :21 20 1991,12( 8) :366 211989,10( 5) :220 221987, ( 1) :39 231985, ( 1) :45 241983, ( 2) :35 251995,16( 11 ) : 488 261991,18( 3) :31323 271991, ( 1) :6 28 1982,3 (6 ) : 13 29 1985, ( 8) :18 30 1987, ( 1) :37 311994, ( 4) :54 321986, ( 6) :46 331984,7 (2 ) : 12 341985, ( 4) :54

27 5 1995, ( 6) :53 36 1986, ( 2) :20 371986, ( 2) :39 381983,4 (6 ) : 20 391984, ( 2) :118 401984, ( 4) :50 411984, ( 4) :2324 421994,15( 7) :322 431984, ( 8) :25 44 1995, ( 7) :54 45 1961,4 (3 ) : 23 46 1991, ( 6) :35 47 1987, ( 2) :59 48 1991,12( 3) :125 491983, ( 8) :341 501985, ( 6) :14 511965, ( 7) :17 52 1986, ( 9) :2324 531995,10( 1) :1112 541988,23( 3) :103 551986, ( 3) :121 56 1985, ( 9) :46 57 () () 1993, ( 1) :25 58 1987, ( 3) :4 591965, ( 8) :19 60 1985, ( 5) :24 61 1995, ( 10 ) : 54 62 1993, ( 7) :4647 631995, ( 11 ) : 2930 64() () 1993, ( 2) :37 651995, ( 3) :56 66 1987, ( 7) :53 671989,7 (2 ) : 31 681986, ( 11 ) : 12 691988, ( 1) :45 701966, ( 5) :40 71 1986, ( 6) 32 : 721994,9 (4 ) : 14 73 1988, ( 2) :17 74 1984, ( 5) :23

28 51986, ( 11 ) : 21 761991,12( 1) 77 1990, ( 4) :45 781986, ( 11 ) : 12 791993,14( 6) :1415 801986,4 (11) :21 81 1995,16( 2) :53 82() ( ) 1995,17( 4) :29 831986, ( 1) :28 841965, ( 7) :17 851985, ( 5) :29 861991,26( 10 ) : 450 87 1983, ( 2) :33 88 1984, ( 12 ) : 41 891985, ( 4) :31 90 1984, ( 1) :14 911986, ( 7) :22 92 1986, ( 1) :26 931986, ( 1) :23 94 1979, ( 1) :44 95 1990,11( 8) :361 961983, ( 4) :40 971992, ( 7) :47 981988, ( 2) :21 99 1988, ( 1) :51 1001993, 16 (4 ) : 47 1011991, (12) :57 1021984, (2 ) : 37 1031986, (12) :550 104 1986, (1 ) : 31 105( ) 1982, 31 (1 ) : 123 106( ) ( )1994, 16 (4 ) : 22

29 ),,, ( ),,,,,,,,,,,,,,,,,,,,,,,, 1.,, :,,,, 6, 4, 2 : 10 g, 15g, 6g, 18g, 12g, 20g, 2 1,1 1 : 13, < 300g, ( 4 800ml) 1 3,, < 600g,, 4 100ml 13,, > 900g,, 4 < 100ml,,,,,, 1 1,,,,, : 9g, 30g, 15g, 12g, 10 g, 18g, 1 10,, 10, 2 2, 19,17 23 45,,,,,,, : 8g, 24g, 6 g, 15g, 12g 11,,,,,

30,, : 12g, 18g, 15g, 12g, 10ml, 3 3,,,,, 3 1, 4 1 5,,,,,, 5,, 10 5 30g, 6 1 20, :,,,,,,,,, 12, 10,, 6 2.,,,,, B,,,, : 60g, 30g, 15g, 1 7,, 42,, 1,, 1 2 1,,,,,,,,,, : 12g, 15g, 25g, 30 g, 20g 6,,, 12g, 30, 7 3. 9g, 15g, 6 1,, 25 8 1 8, : 40, (), 20, 175 ( ),,,, : 12g, 15g, 6g, 20g, 40g, 10g3,,, 15g, 20,,, 10 7 4. 1,,, R T : WBC ( + ) (), 5, 4 2 3,, > 10 5, 14,,,, 30g, 15g, 6g, 3 5, 30,, 3 6 1,,, 12g, 30g, 10 g, 15g5,,, 10g, 15g, 30g 1,,,, 9 3g, 51, 10, 1 1 12

31.,,, : ( 1) (2 ),,,,,,, : 12 g, 15g, 10g, 6g1,, : 12g, 20 g, 10g, 15 g 6 15g, 10g,,, 12,, 13 6. 20, 8, 12 7, 4, 4, 3, 2, 12g, 10g;, 15g, 20g;,, 20g, 12g, 15 g, 30g; 20g; 20 g, 10g: 12 ( 8, 4 ), 7, 1 140, 7, 26. 2 1 4, 8, 1 15, 1 6,, 12 1,, 10g, 12g, 5, 9 1, : 12g, 10g, 15g, 18g 15, 4 1, 5 5 1, 20 8 7. 31, 31, 9, 22 ; 1754, 36. 7, 5 30 : 15 g, 20g, 6g, 10g, 9g, 12g, 5g ; ; ; 1, 7 1 (,, 1 )6 ; ( ) 13 ; ( )9 ; ( ) 2 93. 6 % 5, 28 17 1,,,,, ; ;, ;, 10, 5 18 8.,,, 25 : 10 g, 12g, 15g, 1 : 23 ; 2 3, 12, 7. 5 19 9. 42 80. 3, 3, 2. 5g, 4 8, 30. 6%, 73. 8% 20

32 60% 2 1, 2 2 10. 1, 15,, 30g, 20g, 6,,, X 23 11. 1 3,,,, : (),, 20g, 15g, 1g( 2 ) 1, 3 ( - ),, 9 12. 102 : 54, 40, 7, 1, 99% : 1020g, 1530g, 1020, 1030g ; ; ; 3050g1 500ml 8ml, 1 24 1.,, 1, B :, : 10 g, 15g 5,, 10g, 6g, 5, 25, 7,, A : ( ) 3cm, 1 2cm, :,,,,, 10 : 13 2.,, 1,,,,,,,, ;,, 3, 18 3. 1,,, X : 0. 30. 4cm 0. 60. 5cm,, 1 0. 30. 4cm,, 2 0. 60. 5cm, 15,,, 2, 1 10g, 6 g, 7g, 15g12, 3, 3, 1, X, 2, :, : 24g, 12 g, 30g, 15g, 8g, 6 g, 4g, 1 3 5, 3g, 10g, 24,

33,,,, 26 1, 10 g, 30g, 20 B, X, 6 4.,, 1, 4,, 3,, : 12000/ mm 3, 78 % : 10g, 15 g, 25g, 6, 2 : 8000/ mm 3, 70 %, 4, 15 102,,,, ;,, : 88, 9, 2, 3 2 7 5. 1,,, 2, 2,,,,, : 15g, 30g, 20g, 1,, 2 28 1,,,,,, 6g, 3,,, 6g,, 29 1. 100 10 g, 20g, 30g20g, 10g; 15g, 10g; 15g, 10g; 20g, 15g; 20g, 15g, 10g 1,, 45 1 20 0. 3g/, 4 : 44, 54, 2 ; 0, 17, 3 30 49, 15. 62. 71. 31. 32. 7, 0. 4g, 5, 3, 15 1, 3 : 34 (,,,, ) ; 11 (,, ) ; 4 ( ) 91. 8 % 31 1, : 10 g, 12g, 15g, 1 10 2 5 1,,, 12, 1 3 10g, 15g, 5g 1,, 3, 15,, 29 2.,

34 178 : 92. 2 %, 53. 3%, ( P < 0. 01 ),,, 32,, 1,,, 3 3,, 3 4 35 3. ( 45 ) ( 194 ) () (54 )( 48 ) ( 96 ) 437 8, 1. 8 % ; 383, 87. 7% ; 27, 6. 1% ; 19, 4. 3% ; ; :1 61. 4%, 13 5,,, 91. 3%, 8. 7 %,,,, 3 6 83 36, 47 3g, 2, 36 : 12, 20, 26, 18, 7, 91. 6%, ( P < 0. 05 ),,,,,, 83 3 37 7 g, 10g, 9g, 12 g, 6g 1, 3, 24, 3,, 3 8 1, 3 4,,,,, 5g, 3, 1,, 39 4. 1,,, 9,,,, 40 2, 1, 41 5. 1,,, ; ;,, ; ;,, 8,,,, 33 6., + 44. 4%, + 73. 7 %, 33. 3% 42, 40% 50 % 36 7. 1 2,,, 18,, 30 4 3 1 3, 6, 20 1 5 8. 138, 118, 11,

35 3. 5% 44 24,, 22 X,, 2 0. 5g, 16371, 12, 50 %,,,, 45, 4 6 432 3, 96, 88, 26, 47 9.,, E, E, 48 2, 20, 1,, 49 15g, 10g, 5g, 12g 3 1,,,, 9,, E C 93 ABO, 16 6, 1, 92. 4 % 275 219,21, 11 6,, 50 32, 40,, 3, : 6g, 10g, 12g, 15g1, : 21, 8, 3 10g, 15g; 15g; 15g 51 10. 1411. 511. 5,, 0. 5g, 3g, 2 92,,, 52 24, 5g, 2, 7, 149 11, 9, 91% 1,, 400ml, 22 Apgar,,2 53 9g, 15g, 30 g, 1,, 52 : 2, 28, 22,,, 54 11. 3g, 9g, 10g, 6g, 15g 1, 3 5 5 5 1, 3 4 3 3, 2 15 12. 1,,,

36, 33 1 7, 2, 8,10 55 1 7,,, 10g, 15g, 10 56 13. 1 5, 5g, 10g, 12g, 10g, 6g 4, 8 57 14. 9g, 6g 217,, 1, 3, 2, 3, 9 : 87, 130 128,2 58 100, : 10g, 15g, 8g, 5g ( ) 10g; 15g 1, 2, 4, 3, 1,3 : 1 32,2 48, 3 10 10,, B, 59 40, 39, 1, 97. 5% : 8g, 6g, 5g 10g; 4g; 5g; 10g 1,, 3,7 1 2, 2, 2 6 0 77, 4. 5g, 23,, 77 62, 82%, 66. 7 %, ( P < 0. 05 ) 61 12g, 10g, 6g, 3g 1 8, 4 55 15. 36, B, 8cm9cm 23, 9. 1cm10cm8, 10cm 5 10g, 9g, 12g, 15g 15g, 20g; 15g; 15g, 12g 500ml, 2, 1 23 (, B, ; ) ; 11 (, B,,, ) ; 2 ( 10 B ) 6 2 16. 30 % 35 %,,,,,,, 1 9 4 (10375 mm),,,, ( 1 ) 38 5 3428,,,

37,, 63 17. 90, ( 10g/ ) (4 g/ ) 38, 4 10. 480. 19g/ dl 11. 151. 2 g/ dl( P < 0. 01 ) 64 18. IgG 1 IgG 44, 4,, 2 : 5000mg/ dl IgG H b7. 0/ dl, CRP, 2, IgG, 10 1940mg/ dl,, IgG 6 5 19. 1 17,,, 24/ 17. 3kPa : ( + ) ( + ) 10g, 30g, 15g, 2,, 3 20/ 14. 7 kpa,, 9 17. 3/ 12. 0kPa,, 1, 43 20.,,, 24,, Kupprmann 66, 75% 67 1. 10g, 12g, 15g 1 ( ) : ( ), 12,,,, 68 2. 10g, 12g, 15g, 30 g, 3 1, / 15cm, 1. 0,,,, Bp : 19/ 13. 3kPa, : : ( ),, 15, 0. 6,,,, 68 3. 1,, : 10g, 12g, 30g 30 0. 8,,,,, 1 6 8 4. 1 68, 2 : / 20cm, 0. 4 : 0/ 30cm, 0. 2/ 30cm, : 3. 54 kpa, 2. 74kPa :

38, : 30 g, 10g, 12 g, 15 g, 30 g, 1, 15, 1, 2 0. 2,,, 2. 56 kpa,, 68, 1, :,,,,,,, : 10g, 12 g, 15g10,,, 4 235,,,, : 30 g, 9g, 12g ; ; ; ; ; ; ; ( ), 23 : 58, 69, 87, 21, 91 % 69,,,,,,, 1.,,,,, 7 0,,, 71,, 2 72, 73,,,, 74 12,,,,,, 7 5

39.,,, 7 6,,,,, 3 7,,,,,, 7 7 12 1, ;, 7 8 ; ; 79 3., 8g/ kg, 717, F1 F2 F3,, 8 0 40 27 27,,,,,, 81 4. ( M-CSF ),, M-CSF,, 7. 5g/, 1 M-CSF ( P < 0. 01 ), E2 P4,, M-CSF, M-CSF 82 5., 42 :, 74%, 68% ;, 91%, 1% 9, 1,, 20, NE DA 5 - H T 83,, 8 4 6.,,,, 85 1 1992, 23 (1 ) : 27

40 1994, (10) :55 31983, (10) :20 41982, 3( 1) :9 5 1987, (6 ) : 45 61992, 13 (11) :517 71986, (10) :476 81985, (4 ) : 47 9 1982, (5 ) : 36 10() () 1983, ( 4) :34 11 1980 :1112 12 1984, ( 10 ) : 30 131985, ( 6) :18 141982, ( 4) :31 151985, ( 7) :315 161983, ( 4) :6 171994,10( 1) :30 181987, ( 2) :35 191992, ( 3) :112 20 1989,6 (3 ) : 456 211989,6 (3 ) : 561 221993,15( 5) :38 23 1986, ( 1) :28 24 1993,6 (7 ) : 420 25 1994,25( 4) :13 26 1985, ( 1) :44 271988, ( 1) :30 28 1987, ( 4) :42 291988, ( 2) :45 301992,14( 1) :11 311988, ( 4) :25 32 1989, ( 8) :33 331995,19( 4) :38 34 1983, ( 4) :36 35 1991, ( 5) :50 36 1982, ( 2) :22 37 1983, ( 6) :25 38 1986, ( 2) :20 39 1984, ( 6) :18 40 1980, ( 9) :1407 41 1986,33( 4)

41 21985,9 (10) :85 431988, ( 4) 25 : 441990,11( 4) :154 45() () 1981, ( 4) :56 461985, ( 6) :58 471988,5 (3 ) : 340 481983, ( 3) :217 491984,8 (6 ) : 18 50 1984, ( 3) :137 51 1995,26( 5) :39 521986, ( 12 ) : 714 53() () 1981, ( 2) :55 541985, ( 7) :50 55 1982, ( 5) :26 561986, ( 6) :166 571986, ( 3) :14 58 1984, ( 4) :18 59 1993,24( 5) :44 60 1993, ( 9) :26 61 1987, ( 7) :7 621994,16( 5) :24 63() () 1990,12( 4) :56 64 1989,6 (3 ) : 528 65 () () 1993, ( 4) :36 66 1978, ( 9) :125 671981, ( 5) :35 681991,12( 2) :79 691987,10( 5) :36 70 1981,109 81 71 () () 1988,10( 4) :44 72 () () 1988,10( 4) :46 73() () 1991,13( 4) :41 74() () 1988, ( 4) :44 75 1983, ( 10 ) : 472 76 1984,8 (11) :16 77() () 1990,12( 3) :56 78 () () 1988, ( 4) :42 79() () 1983, ( 4) :14 801982, ( 6) :981 81() () 1984, ( 6) :27

42 2 () () 1994,16( 3) :35 83() () 1992,14( 3) :45 84 () () 1994,16( 3) :33 851991,13( 12 ) : 28

43 ), ( ),,,,,,,,,,,,, ;,, :,, ;,,,,, 14, 1. 9g, 15g, 12 g, 1 2, 5 5 2. 1,,,,,,, 15g, 4. 5g, 4 12g, 10g, 10 5 3. 40, 20 15g, 10g,, 20mg, 3 14 21 : ( 4000/ mm 3, ) 11, 1, 95% ;, 6 10g, 5,,, 7 4. 24 30g, 15 g, 15g ; ;, ; ; ; ; 1,, 2, : 8,, 9, 10 5. 51, : 15, 12, 5, 19 10 : 25g, 35g, 15g, 10g, 10g, 6g 3g; 8g, 30g; 9g, 8g;, 10g, 30g, 20g : (

44 ) 10 ; ( )36 ; 5,, 11 6. 12g, 9g,, 1,4 5 7. 59 : 50g, 10g, 20g, 20g, 20g, 30g, 10g 30g; 5g; 15g1, 2 1 : 5 16%, 23 74%, 90%, P < 0. 01 1 2 8.,, : 30g, 15g, 30g,, 1,, 15g, 8, 15g,, 10, 1, 1 3 1. ;, 25 : 18, 9, 3, 14, 60 1 4 2. 15g, 9g, 6g, 1,2, 6,,, 15g, 6g, 7, 5 1, 9 3. 1 9 1. 12 : 20 30 g, 69g, 10g, 6g, 5 g, 9g ; ; ; ; ; : (,, )6, 5, 1 15 2.,, 1 6, 1 1,3,, 5 9 g, 12g, 1 5 3, 9 g, 4 5 3. 19 17 4., 30g, 12g, 10g, 6g ; ; ; 79, (, ) 61, 18

45,, ; ; ;, 18, 1, 7 20, 12g, 15g; 15g, 12g; 10g, 6g: 16, 4, 0. 58 19 1.,, 24 (5 % ),, 29. 949. 41% 1. 100. 23, 51. 357. 11% 1. 760. 41, 51. 8918. 41% 2. 050. 36, 2,, 20 ( RFC), ( ) RFC, 21 FC C3 b, B ( PFC)T ( - ) 2 2, 2.,, 6,,, 21,,, RNA, 23,,,, ;, 24 3., 1500g/ ml 2000g/ ml ( LD H ), LD H,,,,, 200g/ ml 15,, 32. 35%, 20 19. 38 %,15 27. 34%, 20 47. 27 %,,,, 25,,,,,,,

46,,,,,, Z A, I,,,,,,,,,,, Z A I,,,,,, 2 6 21,,,,,, T,,, 27 520g/ kg,, 10g/ kg, 10g/ kg 10 20g/ kg 28 4. 600, 0. 2ml ( 60 mg/ kg ), 15g/ kg, 3g/ kg, 18g/ kg,, 10, : : 42041, 49831, 51027, 54940 ; : 12. 2, 14. 5, 14. 8, 16. 0,,,,, 29, 2% 0. 5ml/ kg,,, 1ml/ kg/, 6,, ;,,, 30,, ADP,, 3 1 1 1982, (2 ) : 29 2 1982, (12) :30 3 1983, (1 ) : 34 4 1983, (9 ) : 31 5 1984, (4 ) : 35 61987, (3 ) : 43

47 1985, (7 ) : 12 81984, (5 ) : 36 91978, (4 ) : 24 101965, ( 2) :8 111986, ( 10 ) : 468 12 1994, ( 5) :12 131982, ( 6) :41 14 1984, ( 11 ) : 31 151981, ( 5) :9 16 1981, ( 8) :12 17 1989, ( 2) :22 181986, ( 6) :204 191984, ( 3) :21 201979, ( 3) :56 211982, ( 10 ) : 73 221989,12( 2) :43 23 1986, ( 7) :44 241988, ( 1) :27 251988, ( 1) :27 26 1990,12( 2) :25 27 1987,3 (3 ) : 7 281993,14( 10 ) : 472 291989, ( 4) :41 30 1986,17( 5) :44 31 1990,6 (5 ) : 40

48 ),,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, ( ),,,,,,,,, 1. 84 : 20g, 30 g, 12g, 10g, 6g ; ; 1, 36,, 6-28, 3 9 : 63, 16, :, 1 1 (),, 30g, 10g, 6g, 3g3,, 15,, 2 1,,, 2,,,,, 3 1 8,,, 20,, 4 1

49,,, 5,, 5, 5 1,,, 1,, 3, 6 2.,, 2 ; : 1, 1 7 3. 24 ( ), ; ( ), ; (), : 710,, 8 4. 16 12 g, 9g, 15g, 6g ; ;,,, ; ; : 9, 6, 1, 93. 7% 9 5. 1, 15g, 6g10, 30,, 1 0 6. 28,,,,,, 1 14 ( 10, 60 ), 12 ( 10, 50 ), 2 ( ) 1 1 7. 1,,,,,,, 5,,,,, 7, 12 1, 20,,, 17 8. 1,,, 78 /,, 7,,,, T,, 4 9., 1, 9 10. 1,,,, 1, 2,,,,, 1, 14 11. 50, ;, ;

50 ;, ; ; ; ; ; ; 30, : : 13 7, 17 6 16 8, 4 9, 92% 66. 6% 15 50 ; ;, 1, : 38, 9, 3 1 6 1, 21. 524/ 13. 514. 5kPa,, 4, 2 1, 30, 3 12. 20 78 g,1 1, 13 : 11, 8, 1 95 %,,, 18 13. 63,, : 42, 13, 8 16 1 9 14. 31,,,,,, :, ;, ( ) ;, ; ; : 25, 6 20 15. 40 ; ; ; ; ; : 24, 15, 1, 97. 5% 21 16. 32 : 10g, 6g, 15 g,, 5g1,, 2, : 12, 17, 3 22 1 3, 7,, 2 3 17. 1,,, 7,,, 14, 20,, 2 2, 25,, 24 1 CT,,,,

51, 7,,,, 7,,,, 25 1 CT,,,,, 24,, 2 6 1,,,,,,, 3,, 20, 6, 6 18. 3 1: CT,, 3,,, 2,,, 2:, 3,,,, 1 3,, 3:, 2,,,, 3, 27 1,, 7,,,, 56, 2 8 19. 1,,,,,,,,,,,, 2,,,,, 4,,, 29 20. 8 3, 8 3 0 1,,,,,, 6,, 3 31 21. 1,,,, 10g, 3, 1 : 1,, 3 2 22. 12 ; ; : 12 24,, 33, 1, 2, 2,,, 2, 2,, 4,,, 4 1 34 23. 6,, 3, 16 : 6 1 70%,, 5, 7, 15, 3, 5 1, 35

52 4. 52 ( ), ; ; : 52,,, 1 36 25.,,,, ; ; ;, 3 7 10,, ; ; ; ( ), 30 : 7, 2, 1 3 8 26. 1, :,,,,,,,, 4,,, 39 27. 1 C T,, 3, 30,,, 6, 4 0 28. 1,,,,,,, 7, 41 29. 1,, 10,, 4 2 30., 37, 36,1 43 1,,,, 5, 12, 12, 44 1 3,,, 6, 18,, 45 1 8,,, 6,, 46 1,,,, 1,, 3 47 31. 11,,,,,,,, ; ; ;, ; : 24, 46 1, 48

53 2. 1,, 1,,,, 3, 5, 49 33. 88 ( ),, ; ;,, : 54, 30, 4 5 0 34. 1 3,, :,,, 3, 3, 3, 2 3 35. 1 68,, 15g, 12g, 3g, 8g, 10g, 6g 10g/ 10,,, 2 5,, 5 1 36. 1,,, 5, 5,, 52 37., 18, 1,, 5 3 38. 37, : 12 g, 10g, 5g, 20g, 6g ; ; ; ;, ; ; ; ; ; ; : 9, 25, 3 54 1,, 4,, 1. 5,,,,, 5, 15,, 2,, 5 39.,, 18 : 40g, 60g, 80g, 30g, 150g, 8g,, 1 :, ;, ;, ;, : 7, 10, 1 55 1,,, 25,, 15,, 5 6 40. 1, :,,,

54,, 3,,, 20, 6 41.,, 1,, 20,,, 24,,, 57 42., 3 1 3 5 58 1 3, : ; :, 6,,, 9, 5 9 43. 1,,, 7, 5,, 23 1 10, 12 1 3, 60 44. 1, 3,,,, 2,, 4,,, 2 1,,, 2, 6,, 61 45. 1 3,,,, 1,, 3 6 2 46. ( ) 38 ; () 42 : 6, 3, 2, 1 8, 5, 4, 2 1 26, 68. 42%, 23, 54. 76%,, P < 0. 05 63 47. 36,, : 20g, 25g, 8g, 10g, 5g, 30g, 15g, 50g ; ; ; ; ; : 36,, 10, 6 3, 1 64, 10, 65 48. 40, ; ;,, : 20, 16, 4 66 1,,,3,,,, 10,, 8,, 2, 67,,,,,,,

55 6, 6, 6 8 1, 1,,,, 5, 5, 5 7, 69 49.,,,,,, 110, 1,, 7,,, 7, 1,, 7 0 50. 1 :,,,,,, 2,, 3,, 4, 71 51. 1 10,, 2, 72 52.,, 1 3,, 7, 7 3 1,,,, 5, 30,, 32 100, : 76, 20, 4 4, 10 74 1 13,,,,,,,,, 3 1,, 3, 3 3, 75 55 ( ) : 38, 15, 2 3,, 68, 76 1,,,, 5,,, 5, 1, 31 30 : 12, 40% ; 15, 50% ; 3, 10% 77 53. 43 : 30g, 9g, 10g, 12g, 3 ; ;, : 26, 11, 5, 1 78, 16 : 2, 3, 10, 1 7 9 54. 7, : 8 0 1,,, 10, 3, 2 10, 4 2 55. 1 8,,,

56,,, 1, 5,, 81 56. 1,,,,,,,, 30,, 39 57. 1,,,,,,,,, 2, 2 8 2 58. 1,, 3737. 5, 6,, 6 1,, 10g, 15g, 6g, 3g9 5 6 1,,, 1, 51 1 2 37. 5 38,,,, 25,,, 5 59. 1, 38. 540,,,,, 9,,,, 83 60. 1 9 4, 7, 1 84 1 24 2, 5, 1 85 1,,,,,,, 15, 2 60 1 50,,,,,,,, 1, 5, 1, 86 61. 1,,,,,,, 2,, 3,, 6 9 62. 30, 14, 8, 6 7, 4, 3 1, 1, 2, 2, 1, 1 3, 1, ;, 87 1, 3,,,, 3, 6,,,, 9 1, 88 63. 1 10. 6mg% ( 6. 0mg% )

57,, 80,, 8 9 1, 1129mol/ L,,, 5,, 5,, 1,, 2 64. 1,,,,,, : 5,, 2 90 1,,,,, 15,, 10, 10,, 6g, 1, 3, 91 1,,,,,,, ( ), 3,,,, 4,, 3, 9 2,,, 79 : 52, 26, 1 98. 7% 93 38, ; ; 10 1 : 33, 2, 2, 1 23, 4 94 13,,, ;, ;, ;, ; : 13, 12 1 40, 14, 7, 92. 3% 95,, 96 5 65. 20 ; ; ; 2 1 : 9, 6, 3, 2 1 8, 2 6, 3 4 45%, 90% 97 66.,, 1,,,,, ;,,, 8 2 1. 126 :

58 2 g, 10g, 5g, 6g, ; ; ; ; : 6, 98 20 : 4 2, 6 11, 10 6, 20 1 99 28 ( ) ; ;,,,, 100 2. 1,,, 3, 15, 75 3. 1 (B : 4. 0 1. 3cm ) 40,,, B : 4. 52. 1cm,, ( ) 13 3 B, 3. 11. 3cm15 4 B :, 101 4. 11 B CT 1., 2.,, 3., ( ) : 24, 2, 5, 3, 1 10 2 5. 36,, ;, ; ;, : 9, 22, 5, 86. 1% 103 6. 52,, : 510 16, 1115 12, 1625 16, 2640 8 1 04 1,, 20, 5 4 7 7. 1,, 5, 15,,, 1, 23 1,,, 3,, 10,, 105 8. 30 4 30 9, 16, 5 : 15g, 30g, 10g, 20g 50 g, 10ml 710 : 15, 7, 7, 1 ; 11, 2, 9, 3 ; 1 ( ) 106 8 9g, 3g; 25g, 10 g, 15g, 30g87 10 7

59. 1,,, 27,, 120,,, 1 08 10. 1 20, 38,, 10g 3,, 7, 44 1 2, 5, 109 11. 25, ; 10 1, 13 : 11, 12, 2, 92% 110 1, 30g, 2, 10g 12,, 24,, 45 1 X 5 6 7,,,,, 10, 14, 6, 60 12. 1 : : 1,,, 6,,, 45 13. 50, ; ;, ;, ;,,, 1 11 1. 70 : ; ;, ;,, 112 33 : 27, 5, 1 1, 5, 15 3, 16, 4 7, 1, 113 1,,,, 2,, 3, 3, 34 4,, 1 14 1,,,,,,, 3,,, 3 15

60, 2 5 2., 83 ; ; ; ; ; 10g, 12g, 6g 50ml : 41, 27, 10, 5, 94% 115 3. 3 1,, 10,, 5, 1,, 5 1 2,,,,,,, 10,, 3, 11 6 1,,,, 30g, 15g, 20g6,,, 6 3, 6 8 4. 1,, 4060,,,, 6, 3 25 6, 3, 117 1, 4060,, 4,, 24 3, 1, 11 8 5. 1, 30 g, 10,, 15, 5 6 6. 1 5,,,,,, 1 3,,,, 3, 1 19 7. 1 10,, 2,, 3 120 8. 1 3, 10,,,B : 1,, 105 1 50,B : 3. 53. 0cm, H CG > 400ng/ ml,, 15, H CG 10ng/ ml,,, 10,, 2, 1 20 9. 1, 4,, 6, 3, 68 1,, 5,, 56

61 0. 60, 40, 20 O, : 9g, 12g, 6, 3g, 7 7 2, 85% (34 ) 55% (11 ), 121 11. 50, ; ; 1 : 43, 11, 23, 9, 13 86 % 122 12. 152, 97. 3 % 123 142, : 70, 45, 23, 4, 97% 167 1,, 20, 1 24 13. 1, 3, 30, 2 3 14. 104 : ; ; : 68, 27, 9, 91. 4 % 125 1,,, 20,, 14 1 73 1,,,,, 3 ;, 9 75 1 30,, 5, 1 26 50g, 12, 2,, 3,, 3 127 1. 46,, ;, ; ; ; ; ; : 19, 17, 10, 78. 26 % 128 1,,, 3,,, 30g, 20,, 1 10 5 1, 5,, 30g, 20, 1, 8 3 2. 1,,

62, 1 29 3. 1 2,,,,, 10, 10,,, 129 4., 1: 2, 32510 9 / L, 15, 21610 9 / L15, 14710 9 / L,, 2 : 2, 2, 33010 9 / L 32510 9 / L, 1,, 14310 9 / L, 130 5. 1 2, 15,,, 50 1 29 6. 1 3,,,,, 5, 36,,1, 10 5 1 4,, : 3000 / ml, 20%, 25%, 55 %,,, 30,,, 80 8000 / ml, 75% 2 1 1 29 7. 1,, 3,, 2 131 8. 1,,, 5,,, 5 1 13 1 1. 22, 12, 6, 4,,,,,,,,, ;,,,,,,, ;,,,,,,,, : 8, 3, 2 13, 9 132 2. 20 : 12g, 10g 9g, 10 1 ; : 18, 2 1 2, 3 133 1 15g, 10g, 30g 4,,

63 0 g, 20 134 90 1 2,,,, 8,, 135 3. 64 ; ; : 52, 11, 1, 98. 4% 8, 20 1 36 1,, 5,, 5, 5, 1 37 4. 1 3,,, 7, 12,, 138 5. 1 3,,,,, 17 1 13 9 6. 42 : ; ;, ;, 30 1, 23 : 26, 11, 5 6 23 1 40 10, ( ) 15 141 15 18 : 11, 5, 2, 88. 8% 1 42 14, : 13, 1 41, 9, 17 1 2 1 1 2,, 1 143 9, 12 :, : 9, 2, 144 7. 160,, 1,,, ;, ;, ( ) : 67, 79, 14, 91. 25% 1 45 22, 3. 9 14 6 21, ;, ; ;, ;,, : 9, 6, 5, 1 147 8. 2 1 18, 2,,, 1,

64 44 2,, 1 48 9. 1,,,, 4, 4, 41 1, 3, 3,,, 30g, 3 149 10. r r,,,,, 2 1 50 11. 40,, 5, 3, 10 g, 15g1, : 32, 2, 5, 3 151 12. 1,,, 6,, 7 138 13. 35 ; ; B1 B12, 10 1 : 9, 21, 5, 85. 71% 15 2 14. 1 5,,, 7, 15, 1 38 1. 1 20 6, 6,, 6 153 2. 1,,, 3,, 5, 1 54 3. 1, 6,, 3,, 6, 5,, 153, 10,, 15 4 4. 1, 10,, 20, 3 1 5. 60, 48, 22 : 41, 8, 9, 2 96. 7% 15 5 1,,,,, 10,,,, 35,, 3, 1 54 6. 1,

65 7,,, 7, 1, 73 1,, 2 1, 20,, 12 4 7. 1 6, 6, 6,,,, 68 3 156 8. 1, 30 g, 10 g 6,, 6, 6, 1 53 9. 1,, 1,, 3, 6 1 10. 1 25 2, 3,,,, 153 11. 134 ; ; ; : 43, 32, 30, 29, 78. 4% 15 7 12. 18,,,, : 924, 13 158 1, 6,,12, 153 13. 23 ; ; 615, 3050 6, 5075 14, 75 90 3 159,,,, 1. :,,,,, 160 2. 90,, 15,, ( P < 0. 01 ) 161, 25mg/ ml,,

66 6 2 (, ),,,, : 164 3. (, ) MDA, SOP,, 165 4. 17 17 17 17, 24 17 17,, 17 17,,, 166 5.,,, 1 67 11995, 15 (1 ) : 44 2 1993, 25 (11) :49 3 1990, 21 (2 ) : 26 41987, 3( 6) :16 51984, 5( 4) :45 61987, 7( 3) :13 71985, 26 (7 ) : 41 8 1991, 4( 12 ) : 746 91995, 16 (9 ) : 411 101984,5 (3 ) : 27 111992,16( 3) :19 121990,31( 8) :33 131994, ( 4) :26 141992,24( 2) :20 151985, ( 6) :34 161991,26( 5) :200 17 1980,12( 4) :20 181988,8 (10) :601 191994,14( 2) :89 201993,13( 9) :41 21 1989,9 (12) :753 22 1983,5 (5 ) : 17 231992,23( 3) :33 241988,9 (5 ) : 10 25 1994,26( 9) :55

67 61987, ( 4) :47 271987,5 (8 ) : 43 281983,18( 9) :404 291995,11( 5) :29 301985,26( 12 ) : 47 31 1995,27( 10 ) : 56 321985, ( 6) :28 331990,10( 1) :33 341990, ( 2) :14 35 1993,11( 3) :43 36 1991,7 (1 ) : 17 371995,11( 4) :29 381984, ( 11 ) : 9 391990, ( 2) :45 401995,11( 4) :28 41 1995,11( 4) :28 421980,21( 2) :37 431991,11( 6) :18 441995,11( 4) :29 45 1992,13( 10 ) : 464 461995,11( 4) :29 471989,30( 11 ) : 18 481982,3 (2 ) : 14 491995,11( 4) :29 50 1994, ( 6) :12 511987,8 (4 ) : 167 52 1991,22( 6) :20 531988, ( 2) :51 54 1994,26( 1) :50 551987,5 (3 ) : 22 561987,3 (6 ) : 15 57 1992,12( 7) :426 581995,11( 5) :30 591990,11( 10 ) : 465 60 1993,25( 10 ) : 47 611989,10( 1) :28 621988,29( 7) :14 63 1993,28( 3) :107 64 1991,23( 11 ) : 27 651981,5 (9 ) : 15

68 61992,23( 2) :28 67 1993,25( 6) :15 681995,16( 3) :136 691986,17( 2) :27 701993,28( 5) :198 711989,7 (1 ) : 22 721986,4 (9 ) : 12 73 1995,27( 8) :53 74 1983,18( 9) :4 75 1990,22( 6) :40 76 1984,16( 6) :29 771991,4 (3 ) : 182 78 1985, ( 5) :19 79 1987, ( 1) :38 80 1985,3 (1 ) : 3 81 1990,13( 3) :39 82 1992,23( 4) :34 831995,11( 3) :25 841987,5 (4 ) : 43 851981,22( 7) :16 861993,9 (1 ) : 38 871989,10( 4) :29 881995,16( 9) :416 89 1987,7 (6 ) : 330 901982,13( 4) :59 911987,28( 4) :31 921989,30( 10 ) : 15 93 1993,6 (2 ) : 22 941987,11( 1) :9 951993,14( 3) :222 961986,27( 7) :41 971993,12( 2) :21 98 1990,21( 6) :31 991992,5 (6 ) : 33 100 1984, 7( 2) :54 101 1993, 25 (1 ) : 49 102 1991, 13 (4 ) : 12 1031994, 10 (6 ) : 28 1041985, 26 (7 ) : 43 1051991, 23 (7 ) : 42

69 061992, 16 (3 ) : 33 107 1985, 5( 5) :269 1081984, 25 (4 ) : 44 109 1983, 4( 4) :27 110 1993, 16 (3 ) : 5 1111995, 18 (2 ) : 19 112 1984, 19 (6 ) : 270 113 1992, 14 (6 ) : 7 1141992, (6 ) : 7 115 1993, (2 ) : 16 1161994, 15 (12) :557 1171993, 14 (12) :563 1181995, 11 (3 ) : 25 119 1990, 22 (11) :44 1201995, 11 (3 ) : 26 1211991, 11 (9 ) : 569 122 1991, 23 (5 ) : 41 123 1988, 8( 10 ) : 624 124 1990, 21 (2 ) : 26 1251986, 3( 5) :18 1261994, 11 (4 ) : 31 1271985, 3( 5) :22 1281994, 12 (12) :30 1291990, 6( 6) :34 130 1994, 26 (6 ) : 41 131 1995, 11 (5 ) : 30 132 1995, 13 (2 ) : 49 133 1994, 26 (11) :24 1341994, (4 ) : 37 1351995, 11 (3 ) : 26 1361993, (6 ) : 48 1371995, 11 (4 ) : 28 138 1991, 23 (4 ) : 45 139 1991, 22 (6 ) : 55 1401994, 16 (3 ) : 24 141 1986, 7( 10 ) : 460 142 1989, (1 ) : 23 1431991, 9( 4) :40 1441994, 10 (6 ) : 24 1451993, 13 (1 ) : 10

70 46 1992, 2( 2) :843 1471995, 14 (3 ) : 111 1481993, 3( 2) :86 149 1995, 11 (3 ) : 27 150 1992, 2( 1) :20 151 1989, 13 (1 ) : 45 1521996, 12 (1 ) : 29 153 1993, 14 (10) :468 154 1993, 25 (8 ) : 45 1551991, 13 (5 ) : 15 1561986, 7( 1) :27 1571987, (5 ) : 7 1581989, 24 (3 ) : 127 159 1993, 11 (11) :42 160 1988, (7 ) : 29 1611990, (4 ) : 28 162 1993, 9( 5) :9 163 1995, 11 (6 ) : 11 164 1988, 8( 10 ) : 601 1651988, 12 (6 ) : 5 1661990, 11 (1 ) : 522 167 1989, (1 ) : 23

71 ),,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, 1. 1,, 10g, 15g, 8g, 10g, 2 ( 41) 200 g 15g, 12g,, 20g, 3 g1,,,, 1 2 16 2. 2,,,,, 30g, 20 g, 4 2,,,,, 3 4 3. 1,,,,,,,,,,,,,, :,, : 30 g, 12g, 6g, 15g, 3 g( ) 1, 2 3,,, 2 5 4., 1520g, ;, 6 5. 1 : 15g, 40g, 25g,, 10g,,, 15g,, 2 1 7 6. 1,,,, 30g, 15g, 10g, 13 8

72. 1,, 15g, 20g, 10,,, 1, 2,,,,, 10g, 20g, 15g5,, 5,,,,,,,,,,,, 1520g,, 8 6 9 8. 1,,, 30g, 18g, 5g, 2,,,, 1 0 9. 1,, 20g, 30g, 4,,, 25g, 30g, 4 10 10. 1 5,,,,,,,,,,,, : 10 g, ( )20g, 15g, 6g, 30g, 3g ( ) 3 3,,, 11, 2030g, 6 11. 1,,,, 11. 6mmol/ L ( ),,, : 10g, ( )20g, 30g, 12g 20,, 6. 1mmol/ L, ( - ),, 5. 56. 5mmol/ L, ( - ) ( + ) 11 12. 32,, ; ;,, ;, ;,,,, ;, ; ;, :32 12 47,, 3, 16, 40 37, 7 7, :,,,

73 13 1 5, 2 2 14 1 9,, : 90g( ), 30g, 15g, 9g, 6g, 3g 4 2 1. 15, 4 :, ; ; ; ; :15 15 2. 1 2 3 :,,,,,,, 9g, 20g, 5, 16 1. 1,,,, ;,, 1 1 2. 96 3 60,,, A ; 46 36,,,,,, B : 40g, 15g, 12g, 10g, 20g 30,,, : A 3 ; B 46, 30, 5, 1 17 52, : 12g, 30 g, 9g, 30g(), 15g, 15g( ), 6g, 1, 2, 81. 5%,,,, 24, 2,,,, 18 11989, (1 ) : 38 2 1992, (2 ) : 25 31989, (1 ) : 28 4 1988, (1 ) : 18 51993, (5 ) : 228 61981, (2 ) : 35 71988, (4 ) : 40

74 1987, (10) :16 91995, (10) :676 101988, ( 1) :19 111993, ( 5) :228 121983, ( 3) :38 131985, ( 4) :20 141984, ( 5) :30 15 1980, ( 3) :22 161989, ( 2) :16 171994, ( 10 ) : 52 18 1995, ( 4) :9

75 ),,,,,,, ;, 1,,,, ;,,,,,,,,,,,,,,,,,,,,,, :,,,,,,, ; ;,, ;,,, 1. 53,, : 1 20ml, 6, 12 1, 7 1 : 68 %, 32% 1 21 :, 1, 2 ; ; : 85. 7 % 2 12 :, 150ml,,, 1, 12, 1 : 83%,,,, 3 2. 180, : (, 3g)26cm, 6 8 12 2 ( 25 mg ), 12 mg, 5% 1 : 160, 90. 6% 4 3. 49 :

76,, 23, 1, 50ml : 37, 75. 5% 5 4. 109 1. 6 g/ 4, 4 2,7 1 : 60, 21, 28 6 5., 3, 1,, 2, 18 7 104, 1, 3 1/ 4,46 1/ 2, 2,, 76% 8 6.,,,,,,,, 1, 23, 9 7.,,,,,,,,, 16ml,,, 1 10 8. ; 184, 88 % ; 11, 12, 9, 38 472, 27. 2 :, 1, 2, 35 1 3, 3, 92 6 9 9. : 1,, 23 1, 27. 6 6 ; 10 ; 1 ; 3 60 : 2, 13, 5 14 10., 3, 20, 6,,,, 2,,,,, 1, 3,,3 20,,,, 1, 2,,, 14, 1 5 11. :,, 16 12.,

77,, 1 7 2040ml, 10% 500ml,, 16, 100% 18 13. 40 60ml, 5 % 10% 500ml, 30 60, 26 1 10, 20, 5, 1 96. 1% 19 14.,,,, : 2,,,, 39,,,,, : 12g, 30g, 6g, 15g 7,, 15g, 1,,, 4 1, 2 0 15.,,, 21 16. 1,,,,,, 40ml 5% 500ml, 1 /, 1, 1 ( 15 ), 22 17. 2,,, 23 18.,,,,,,,,,,,,, 8 5% 500ml, 10 7, 3 2 4,,,,,, 25 1. 50, 3, 3, 3,, 48, 1, 1 26 2. :,,,, 1, O C T, 1 1/ 3, 1, 2,, 3

78,,,, 1/ 2, 10,, ;,, 1/ 2,,, 2,, 2 7 3. ( ) 28 24,, 46 1, 2,,,,, ; 5 7 1 12, 18,, 6 29 1.,, 3 0, 3 1 32,, 2. 3 1,,, 3 3, 32 3. 34 0. 81ml 5,,,,,, 35 31 4.,, 32,, 1 ( P < 0. 001), 56 3 1 3 3 30,,, 60,,, 40,,, 3 0,, 5. 31 14. 5 ( 0. 54 ),,,,

79,,, 6.,, 7. 55. 4kPa, ;,,,,,,,, ;, ; 3 1, 3 3 36 7. ( LDH ),,, LD H,,, LDH, ( P < 0. 001 ),,, 16, LD H LD H, LDH, LDH, LD H, LD H 37 11993, (2 ) : 33 2 1994, (2 ) : 3233 31990, (1 ) : 20 41988, (11) :689 51988, (6 ) : 375 6 1995, (6 ) : 244246 71988, (6 ) : 259 81992, (11) :647648 91991, (1 ) : 36 10 1983, ( 3) :113 111985, ( 8) :376 12 1983, ( 2) :6 131994, ( 9) :545 14 1991, ( 2) :3738 15 1990, ( 1) :13 161993, ( 3) :106 17 1988, ( 6) :17 181991, ( 3) :34 191986, ( 2) :122 201987, ( 6) :7 21 1986, ( 1) :34 22 1989, ( 7) :13

80 3 1987, ( 2) :42 241986, ( 4) :215 251985, ( 9) :401 26 1987, ( 5) :300 27 1989, ( 1) :19 28 1991 :99 291985, ( 8) :376 30 1984, ( 3) :6 311982, ( 5) :23 321981, ( 6) :32 331978, ( 5) :22 341981, ( 3) :33 351979, ( 1) :13 361983, ( 4) :28 37 1981, ( 6) :33

81 ( ), (, ),,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, 1. 1,, 12, 3 1, 1, 3, 2,, 2, 2 2. 1, :,,,, 6 3 3. 1 12g, ( ) 5g, ( ) 10 g, 3g, 6g5,, 4 ( ) 1 3, 64 /,, 68 /,, ( ) 10g, 15g 15,, 66 /, 35 / 1,, 12, 5 4. 33, :,,,, ; ;, ;,, ; ;, 1, 3, 30 : 24, 3, 13 1, 5 2, 6 0

82, 2 6 5. 40, : 30g, 10g 15g; 10g, 30g; 10g; 10g 1, 10 1, 30 1, : 4, 30, 4, 2 7 20 20, 11, 9 ; 1740 15,4160 4, 60 1 : 15, 1, 2 50 /, 12, 18 : 15g, 12g, 10g, 1,, 15 1 : 12 ( 60 /,, ) ; 6 ( 50 /,, ) ; 2 90% 8 ( ) 1, 40,, 48 / 5860 /, 9 1, ( ) 15, 50,, 52 / 62 /,, 5 17, 10 6. ( ) 1,, 6,,, 10g, 6g, 60,,, 5, 9 7. 1 10, 12 10/ 87kPa,, : 20g, 10g, 6g2,, : 13/ 10kPa5, 2, 11 8. 63, : 50 g, 12g, 10g, 9g, 3 g 30g, 15g, 12g, 20g; 30g, 15g, 12 g, 9g; ; 1, 100ml 10 ml,, 1 7 1, 7 : 35, 22, 6 1 2 9. ( ) 30, : 30 g, 10g, ( ) 3g, 2g 13, 10 1 1, 2,, 14, 15g, 12g, 10g, 10g, 10g, 8 3, 10, 15 5 1 : 2g ( ), 5 g, 10g

83 ), 10g, 5g, 3g, 15g, 10g, 1 2,, 4 1 6 10,,, 1,, 3,, 10, 1 1 7 1 20, 8,, 18 1,,, 1 9 1 2, 6, 3, 20,, 20 1 10, 6,,, 2 1 1, 8, 2 2 1 15,,, : 6g, 6g, 12g, 12g, 3g, 10g, 109g 5,, 10g, 30,,, 9 1, 6,, 20,, 3, 23 119 30g, 15g, 3g, 10g, ( ) 5g1,, 30 1 : () 74, 31, 12, 2, 98. 3% 24 10. 1,,, 6, 1 2 5,, 12,, 1 20, 1, 32,,, 23 1 5,, 30,, X 20 ( ) 1 18, 40, 23 1,, 120, 26 1,,, 5 2 7 2 50 60,,, X,

84 8 10, 10 6, 2 20g, 10 g, 15g, 5g1,,,, 0. 3, 2mg,, 10,,, 0. 2,, : 10 6 1,3 4, 2 2 ; 2 ; 1, 29 93 : 30g, 15g, 6g, ( ) ( ) 1. 5g, 20g, 10g: X, ; ( ) ; ( ) 1,15 1, 57 : (, )23, 44, 26, 70% 30, 3 1 1,,, 32 11. 1,, 3 3,9, 11 12. 1,,, 60,,, 3 3 13.,,, 34, 1 48,, 1, 1 1 12g, 1, 3,, 3,,,, 2 1, : 5g, ( ) 10 g, 15g, 9g, 6g 60,, 1,, 3 3 14., ;,, 6,, 20 15. 5 1,,, 5,, 15,, 2 22,,,, 35 ( )1, 36 26 30 g, 10g, ( ) 3g, ( ) 15g, 2g, 5g, 1g, 15g, 30g;, 10g;

85 g; 20g, 15g; 10g, 15g 1 10 1, 3, : 17, 6, 3 37 16. () 1,,,, 10,,, 30, 2 17., 1, 33, 3, +, : 30 g, 10g, 12g, 6g, 9g, 15g, 3g10,,, 10,, 3 8 18. 1,, 2, 1 3,, 10, 3, 18 19. 10 8,, 18 20. 1 74, 10,,, 20 2 21., 40 : 30g, 9g, 6g, 12g, 12 30 g: 26, 12, 2 3 9 24, 12g, 10g 10g; 15g, 10 g1, : 16, 8 4 0 24, 4 1, 30,, 3 3 6g, 10g, 15g, ( ), 4 2 48 30g, 15 g, ( )5020g, 5g, 6g, 10g : ; ; ; ; ; ; ; ; ; 1,, 2 3 : 25, 19,, 2 4 3 22. 30 60g, 15g, 4. 5g, 9g, 12g, 4. 5g,, A D B C,, 25, 4,1, 96. % 1220 44,,, 1,, 168 : 130, 28, 10 4 5 18, 1530, 15, 2, 1 4 6 1, 42 1 13,9 ( ), 3 ( ), 1 21, 4, 812 47 20g, 12g( ), 6g, 6g, 9g, 6g,

86 0g, 10g, 10g, 12g, 6g, 28 28 17 ( 60. 71% ), 10 (35. 71% ), 1 ( 3. 5g% )8, 20 48, 2 17 21 49 50 5 1 23. 1,,, ( )5,,, 10, 5 2 24., 1,,6 53 25. 63 : ( )20 g, 15g, 50g, ( ) 10g 30g; 50 g; 15g, 6 1 1 : 63 43, 14, 6, 90. 4% 6, 1 54 26., 19 5 2 27. 1 4, 4,, 2 5 5 28. :,,,,,, 15, 130 56 29. ( 1. 5g ), 20, ; 40 57 30. 3, 10 4 6 31., :,,,,,, 1 8 32. 1 3,,,, 33, 5 8 33. 64 : 30g, 24g, 3g, 15g, 6g, 1 ( )1 1 : 19, 22, 20, 3, 95. 2% 59 34. ( ), 2 1, 6,, 4, X, 2, 4, 3,,

87, 60 30g, ( ) 12g, 5g, 5g, 20g, 12g, 30g, 1 8,, X 61 2 1,, X, 10,, :, 62, 8 :, 6 3 1.,,, 4, 5 5 2. () ( ) ( ) 50 ; ; ; 45, 2, 3 64 3. ( ),,, 8,,, 65 4. 10, 1, 10 68 6 6 3, 27, 3 6 1 63 5. ( ),, 20 21 6., 1 15, 39 67,, 12,, 68 7., 1, 40, 6 9 8.,,,, 59, 1/ 3,, 6 1 4,,, 67 9.,,,, 12,, 7 0 10. 1,,, 3, 1 6,, 3, 71 11. ( 30g, 2g, 3g, 15g, 9g, 6g ),,,, 72,

88,, 12, ( ),, 73 1,, 2,, 30g, 8,, 5 10 ( ) 7 4 12. (30g, 5 g, 20g, 10g, 3g, 3g, 5g) 56 : 53, 2, 1, 98. 2% 75 13.,,,,,,, 18 7 6 14., 15 7 7 15.,, 30g, 20g, 10g, 1 7,, 15, 37,,,,, 3 16. 20 : 12 (,, ), 8 (, ) 78 1, 31, 1, 1, 40, 73 1, 7, 1,, 5,,,, 1,, 79 60 g, 30g, 10g, ( ), 42 17.,,, ( 1,, ), 5, 8 0 1 2,,, 9,,, 2 81, 1, 15, 30, 82 8 1, 2 22 55 5 8 3 18.,,,,,,, 17, 14 630, 3 84, 82 1.,,, 12,42, 3 1,,

89 85, 1, 25, 3 3 2. 3, 7, 8 2 3. ( )1, 30,,40 82 4.,,, 25 1 85 5. 30, ; : 86 ( ), 8 82 1. 210, : 30g, 10g, 6g, 4g, 8g, 20 g, 1, 5g ; ; ; ; ; 1,, 1 6, 5 1 : 148, 70. 48% ; 28, 13. 33% ; 16, 7. 62% ; 18, 8. 57% 91. 4%, 1 74, 2 54, 3 20 87 62 : 30g, 6g, 10g, 12g, 2 ; ; ; 1 60,, 1220kg, 1, 68, 5,, 20 1 : 43 30, 8 12, 9 12, 2 6 96. 77% 90. 00%, 17. 60 6. 25 32. 717. 16 ( P < 0. 05, 0. 01 ) 88 2. 19 :,, 1 ;,, ; ; : 11 (, 1 ) ; 5 (, ) ; 3 84. 2% 89 3.,, 90 1 ( 3. 5 ), 20,,,,, 91, 4 2 67, 10, 92,, 1 10,, 7 3

90. (,,, ) 53 : 13 46,46 6, 1 12, 98. 1%, 1, 93 5. 43 ; ; : 31, 12 9 4, 14 91 10,, :,, 1 1 1, 3, 1 7 6.,, :,, 24,, 77 7. 32 20g, 12g, 10g, 6g, 2 1,, 7 1 6, 15g, 10g : 15, 9, 6, 2 93. 8% 95, 6 1 7,, 1, 1, 9 9 6, 97 8. () 60g 42 9. 21 ; ; ;, 1 20 g,, 3,,, 15 1 24, 10, 5, 4, 2 98 10. 51 : 30g, 10g, 6g, 2 ; ; ; 1 : 13, 16, 14, 8, 84. 4% 99 1.,, 28, 2, 77 : 24, 0. 4 / ml,,,, 20,, 15g, 20,, 4 1 00 4,, 4700 / ml, 50%, 30 %, 10 1, 5 1 40,,

91 1 1, 0. 5 / ml, 25%, 45, : 0. 85 / ml, 60%, 101 2.,, 12, 3,,, 2 5 3.,,,, 9,, 25 4. ( ) 5 g, 9g, 4. 5g, 1 5,, 15, 1 01 5. 7,,, 3, 5, 10 0 6. ( ) 3, 3,,, ( ) 2,, 15, 100,,,, 12,, 20, 38 7. 9g, 4. 5g 14, 14,, 101 8., 15, 7 7 1.,,, 32 ( 20g, ( ) 10g, 3g, 9g, 6g) 1, 5, 1 3, 3, 1 02 4,,, 56,, 33, 2, 3 17,, 6,,, 39 2.,, ; ;, 103 1,,3,, 3, 104 3. 1, 2, 1 05 4. 1 ;

92,, 18,, 30g, 5g, ( ) 10g, 20g, 30g, 15g10,,,,, 5, 20, 35,, 57 1 06 5. 2,,,,,, 1 8 1, 50,,, 3, 5,, 19 ( ) 1 7, 7,, 107 1,, 5,, 10 8 6. 3,,,, 14,, 1 07 1 3, 15, 32 7.,,,,, 10,, 30, 9g, 2 /, 4,, 38 3,,2 3 8.,, 3,,, 35 9. ( 20 g, 10g, 12g, 6g, 26 : (, B ) 23 ; (, )2 1 536 10 9,, 36 1/ 2, 57 67 10.,,,,,, 2,,, 3,, 107 11., :,, 7,,,, 10,,,,, 110 12., 30g, 4560g, 12 g, 3g, 2g, 5g, ( 28, 12, 9, 8 ) 57 43, 11, 3, 94. 7% 44

93. 1,, 8, 1 04 2. 1, 11 1 3. 3, 37,,,,,,,, 39,,, ( ) 1,,,, 3 61 4. 8 3,,,,, 4 102 1.,, 2,, 6,, 2, 3 11 2,, 113 2. 9,, 3, 6,,,, 112, 1, 5,,, 10, 5 2 120 30g, 15g, 1, 1 1 23, : 82, 14, 13, 11 114 3., 1 2,, 4,,, 3 63 4.,,,,, 2 3 4g, 9g, 3 2,, 18 2,,,, 3 5 1 15, 6 63 5., 1,, : 9g, 12g, 6g, 4. 5g 3,, 2,, 112 6.,, : 15g, 3g, 9g, 6g, 10g, 1, 2 102

94. 32, 2,,,,, 1, 15, 16 68 2. 32 : 5, 20, 7 27, 9 : 30g, 3g, 10g, 6g, 5g 1,1 1, : 14 ( 1,,, 1 ) ; 13 ( 1,, 1, 1 ) ; 5 ( 1, ) 5 ; 20, 18, 2 ; 7 4, 3 11 6 11980, (3 ) : 37 21990, 25 (7 ) : 328 3 1991, (12) :45 41988, (9 ) : 50 51994, 10 (5 ) : 28 6 1987, (2 ) : 14 71986, (3 ) : 10 8 1991, 18 (12) :19 91988, (4 ) : 27 10 1981, ( 2) :60 11 1994,15( 8) :374 121993,28( 9) :389 131985,2 (3 ) : 40 141986, ( 7) :22 151981,22( 9) :25 161985, ( 5) :15 17 1995, ( 7) :52 18 1983,4 (6 ) : 12 191987, ( 4) :52 20 1989, ( 1) :13 211985, ( 4) :20 22 1994, ( 12 ) : 45 231992,13( 11 ) : 515 241994,12( 10 ) : 32 251991, ( 6) :43

95 61985, ( 8) :41 271985, ( 2) :44 281983, ( 4) :41 29 1995,8 (9 ) : 559 301994,29( 12 ) : 4344 311988, ( 5) :23 32 1984, ( 10 ) : 45 331985,6 (8 ) : 357 341981, ( 2) :8 351988, ( 3) :19 361988, ( 5) :39 371992,13( 2) :1516 38 1986, ( 5) :43 391980, ( 3) :59 401987, ( 5) :31 411988, ( 1) :26 42 1985, ( 6) :44 43 1990,13( 6) :9 441990,11( 2) :14 451982, ( 11 ) : 36 461983, ( 4) :22 471986,4 (9 ) : 45 481991, ( 3) :41 491986, ( 6) :42 501985, ( 4) :25 51 1988, ( 1) :16 521986, ( 6) :30 53 1983, ( 5) :18 541991,12( 4) :160 551991, ( 6) :38 561983, ( 4) :31 571980, ( 1) :21 581988, ( 3) :22 591991,12( 6) :245 601984, ( 5) :48 611983, ( 11 ) : 21 62 1984, ( 3) :59 631994, ( 9) :532 641982,6 (1 ) : 32 651991, ( 12 ) : 20

96 61973, ( 11 ) : 23 671987,8 (9 ) : 22 681985,9 (1 ) : 23 691964, ( 1) :38 70 1984, ( 3) :31 711989, ( 1) :42 721987,16( 3) :127 731985, ( 4) :21 741986, ( 6) :44 751993, ( 2) :24 76 1983, ( 3) :61 771991, ( 1) :56 781982,17( 2) :82 79 1990,11( 2) :35 80 1988,12( 10 ) : 17 811984, ( 2) :21 82 1988,19( 2) :24 831984, ( 3) :35 84 1981, ( 5) : 851984, ( 2) :16 86 1989, ( 3) :42 871994,13( 1) :31 881994,6 (2 ) : 2728 891991,12( 10 ) : 465 901985, ( 9) :42 911985, ( 3) :44 92 1975, ( 2) :50 931995,8 (6 ) : 29 941992, ( 2) :39 95 1994,13( 3) :35 96 1989, ( 4) :47 971987, ( 4) :37 981993,9 (1 ) : 810 991995,13( 1) :46 100 1991, (9 ) : 41 1011989, 24 (8 ) : 344 1021993, 14 (6 ) : 279 103 1987, (2 ) : 81 104 1987, (2 ) : 39 105 1988, (11) :38

97 06 1994, 10 (5 ) : 28 1071991, (12) :19 108 1988, (11) :38 109 1989, (11) :40 1101986, 21 (8 ) : 373 1111965, (11) :1126 1121991, 12 (6 ) : 268 113 1986, (8 ) : 26 1141996, 31 (1 ) : 20 1151986, (4 ) : 175 116 1994, (9 ) : 51

98 ) ( ) ( ) ( ),,,,,,,,,,,,,,,,,,,,, 2, ;, ;,, ;,, ; ; ; ;, :,,,, 1. ( ), 1,,,,, : 24/ 13. 5kPa,,, 30g, 12g, 1, 4,, 22. 5/ 12. 5kPa, 6,, 21/ 11kPa 1 2. 15 4, 11 2556 ( 32.5 ) 2 30 ( 5.6 ) 2 3, 34 12, 6g, ( ): 15 8 2, 3, 1, 3, 80 % 2 2 1,, 2,,, 10g, 20g, 18g, 12g, 8g 1, 30g,2 1, 25, 3, 2, 8,, 3g, 9g, 12g, 20g1,, 2 1, 8,1, 3 3 3. () 1,, 5,,,,,, 5,,, 15g,,,

99 4. () 1 5, 5. ( ) 1 5, 6. 600 2 147,, : (, ), 6g, 2 12g, 18g, 35, 15 : 93 ( 3. 03kg ) ; 27 ( 6. 57kg) ; 27 ( 1. 06kg) 11. 5kg 19 1640,,, 6 7. ( ) 1,, 4,, 30 g 7 8. ( ), 19,, 315 1 1,,,,,,, : 9g, 15g, 6g, 12g 3, 3, 2, 8 9.,, 9 1. (), 1,,,,,,, 30 g, 1,, 7,, 3 1 2., 9 3., 1,,,,,,,,,, 2, 6g 2,, 20 12 10 4. 113 : 10g, 15g, ( )( ) 9g, ( ) 60g, 5g, 30g, 6g, 12g, ;, 1 : 97, 9, 3, 4, 96.5% 11,,,,

100 12 200 118, 19, 40, 23, ;,, ;,,, :,, 175 ;,,, 16 ;, 9 13 1. 29 : 10 g, 30g8 g 12g( ) 15g 6g :, ; ; ; : (,, )9 ; (; ) 13 ; ( )7 14 1 2, 7,, 4 3 1 2 12 1 5 1, 1 6 10 2. 1,, 3,, 5,,,, 13 12 1,,, 7, 11, 15, 1 7 3. 1 3,,,,, 3,,,, 3, 12 1,,,, 5,, 3,, 15 4. 1, 1,, ;,,, 30g6, 28,, 2, 1 5 5. 1, : 10 g, 45g, ( )30g, ( ) 15g, 5g1,, 2/ 3,,,, 3, 12g, 30g, 3, 1 6 6. ( ) 1,,, 1 5,,,,, 12g, 10g, 6 1 8 8 1,, 20, 2, 2 ; 5, 2, 4

101 10,, 50, 2, 1 (6 g),,,, 30, 450g, 2, 15g 1, 3 19 7. (, ) 94, 20 8. 1 ( )150 ( 6g), 1, 2 2,, 1 9 9. 1 ;, 5, 12 10. 1 2,, 3,,, 3,,, 2 12 11. 1,,, : 10g, 15g, 6g, 5 g1, 2/ 3,,2,, 19,,, 1 6 12. 1 1, 3,,, 10, 1 2 13. 1,, 3, 3,, 5 12 14. 1 1,, 38. 7, 1.7200/ mm 3, 3,,, 5, 12 15. 5 1, 12 1. ( ) 1, 3 2 1, 15g, 10g, 3g, 1, 1, 3,, 5, 7, 1, 3 22 2. () 1 1,,

102 9g 4, 9g, 5, 13 1 22 3. () 1,, 6g, 12g 8,,,, 13 1 22 4. ( ) 1 9 g, 6g 8,,, 9, 0. 7 2 1 1 2 2 5. 2 1,,,,,, 2,,,,,,, 23 6. 1 :,, 9 7. 1 :,, 39.,,, 25g, 4g, 6g, 10g 3, : ( ), ( ), () 1,, 5, 1,, 1 4 ( MSG) 16 ( MSG )16 () 4.7%,8 ( BAT ), BAT BA T ( M T) C, BAT (GDP ), :,,, BAT, BATMT C, BATMT GDP, BAP 24 6 78 wistar, 7 (),, 3 ( 1000ml 7.5g ), 11 ;, 11 3 :,,,,, ( P < 0.05),GOT, GP T ( P < 0.05 ) 1 2 24 3,

103, 8, 7 5,, (1g )( PWV), :5,, PWV,, 5,,, G AGS PAS,,,, 26 11985, 6( 8) :353 21989, 30 (6 ) : 17 31985, (11) :35 41989, (3 ) : 48 51993, 17 (5 ) : 17 61988, (2 ) : 26 7 1991, (5 ) : 55 81984, (6 ) : 57 91992, (1 ) : 41 10 1990, ( 2) :220 111992,5 (2 )3839 12 1984,15( 5) :61 13 1990,11( 11 ) : 514 141989, ( 4) :17 151983,18( 8) :354 16 1987,8 (8 ) : 362 171991, ( 1) :45 18 1988, ( 6) :42 19 1981, ( 2) :20 20 1985, ( 3) :135 211986,27( 3) :40 221994,15( 2) 85 231988, ( 3) :36 24() () 1995,17( 3) :33 25 () () 1994,16( 5) :26 26 () () 1995 ;17( 5) :17

104 ),,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, 1. enalapril 5, 9g 3, 2, 2, 1, 24, 1,, 10,,,,,,,,,,,,,,,, : 30g, 15g, 12g, 6g, 4 1,, 1, 2 154, 103, 51, 15, 62, 1545 : 23, 31, 76, 24 100 %,85. 7% :, ;,, ;,, 3 2. 1, 10,,,,,,,,,,, X :,,,,, : 15g, 12g, 10g, 6 1, 2, 6 4 1,

105, 1,,,,,,,, 3, 1, 2, 6,, 5,,,,,,,,,,, : 15g, 6g, 18g, 10g, 12g, 10g, 10g, 3g12,, 6 3.,, 1,,,,,,,,,,, : 15g, 10 g, 5g, 12g, 9g, 3g, 3, 2, 6 7 4.,,,,,, 1,,,,,,,,,, 4 5. 30, 14, 7, 4, 5,,, : 15g, 10g, 5g, 3g, 1, 2, : : 10, 25 ; : 10 5 ; 100% 8 1, 10, 1,, 3,,,,,,, : 15g, 10g, 3 g, 9g, 5g, 3 2, 3 7 6., 20,,,,,,,,,,,,,, : 18g, 5g10g, 20g, 10g, 10g, 5g, 5,,,,, 10,,,, 6 7., 1,,,,,,,,,,, 10,,,,, : 15g, 5g, 10 g, 12g, 21g, 8g, 5 g, 3g 3,,,, 10,, 6 8. 80, 28, 52, 2035, 3 11, 10 1, : 1 52 ( 65% ), 2 28 ( 35% ) : 46 ( 57. 5% ), : 34

106 42. 5% ) 9 9. 17 ( 16, 1, 54. 113. 6 ),14 111, 5. 42. 8 11, 6 10mg : 13, 2, 2 10 10., 5, 2,,,,,,,,,,,,, : 30g, 5g, 20g, 10g, 15g, 6 g, 4 2,,,,, 30g, 12g, 2, 30, 2 11.,,,,,,,,,,,, : 50g, 15g, 3g, 20 g, 10g, 6g, 3 3,, 6 2 12. 10, 2, 4, 1, 2, 1, 60% 11 13.,,,,,,,, :,, 3,,, 9g/, 7. 5g/, 2. 5g/ 2,, 1 2,,,,, 2,,, 1 2,, ( 39),,,,,,,,,,,, 1, 1 3 14., 6, :,,,,,,,,,,, : 30 g, 20g, 15g, 6g, 3 20,,, 2 15. 42, 3, 15,,,, :, : 3, 9 20, 15, 4, 3 92. 8 % 14,4,, 6, 1,,,,,,,,

107,, : 12g, 15g, 12g, 8g1, 2, 4,,,,,,, : 12g, 10g, 5g, 9g, 3g, 15g, 3 3, 7 16., 3,,,,,,,, : 60g, 20 g, 15g, 20g, 10g, 5g, 10g, 7, 3, 2, 1, 15g, 5,,,,,,,, 6, 1,,, 15 17. 1,, 1,,, 66mm/ ln, O 625, 123 %, :,,,,,,,,,,,,,, 38,,, : 7,,, 14, 1 6,,,,,, 1 7 1., cam P, 3, cam P, camp, cam P 18, camp 100500nmol/ g 1 9, 46, cam P, camp/ cgmp 18, camp,, 2., K K-CA,

108 500mg/ kg, 6,, > >, K K-CA,,,,, 2 0 3.,, 4g/ kg, 1ml/ kg, 2 1, 4 ;,,, 22,, 2 2 4.,,, 23 21 25, 22 24,, - 26 I,, 27,, 54. 6%,, 38. 2 % 5g/ kg,12. 5g/ kg 25g/ k g, 8 6 R6 18. 6% 29. 8% 49. 5% 23, T, 28,, 26 28,, 27 5. : SOD, ( 10 g/ kg, 20g/ kg) ;, 3 0 11991, 8( 3) :424 2 1994, (5 ) : 56 31987, 5( 4) :25 4 1995, (4 ) : 53 51986, (6 ) : 48

109 1989, (3 ) : 43 71983, (1 ) : 31 81990, 14 (8 ) : 36 9 1992, (4 ) : 30 10 1989,102 (5 ) : 19 11 1993,43( 5) :33 12() () 1992,14( 1) :48 13 1983, ( 2) :21 141989,7 (9 ) : 21 151985, ( 12 ) : 11 16 1983,18( 12 ) : 537 171986,3 (3 ) : 19 18() () 1980, ( 6) :264 19 () () 1980, ( 1) :39 20() () 1981, ( 6) :10 21 1960, ( 10 ) : 22 22 1986,3 (2 ) : 28 23 75 1985: 454 24 1983,18( 4) :53 251982,13( 9) :27 26 1968 :172 27 1985,2 (1 ) : 39 281984, ( 7) :44 29 1984,4 (1 ) : 53 301995, ( 5) :1

110 ) (),, (), ( ),,,,,,, 1.,, ; 2.,, ;3.,,,,, ;, ;,,,,,, 246, : ; 3145 ; ; :,,,,, ;, ;,,, 3 ;, 1 1.,,, 1 4,,,,, 10g, 5 9 7. 5g, 2, 10, 3,,,,, 1,, 4, 4 3g, 10g, 12g, 9g, 24g, 2g(), 1 7, 5 1 6 1, 2,,, 2 3 6, 13, 12, 1, 212, 7 2 1, 50, 22,,,, 8 2, 31,, (?) ;,

111,,,, 3,,, 7,, 1,, 8 10 g, 30g 1,, 3 3g, 5, 9 15g, 15g, 30g, 15g, 20 g, 15g, 6g, 1 17,,,,, 1 0 ( PS H )25 25, 7. 5g, PS H 3 : ( 12 )9, 6, 5, 5, 1 1, 2, 2 g, 1, 12,,, 1 3 2.,, 1,, 1 10g, 6g, 2, 3,, 30 9 3. 9g, 24g, 6g, 1 4,, 3 14 15 g, 20g, 1 3, 3, 10, 15,,,, 2 16 4., 32,,,, : 28, 4 3 17 100, 58, 984, 21, 51, 20, 18, 11, 89% 18 10g, 6g,, 1,,,,,,, 30 3,, 8 9 5., 1,,, 21/ 14kPa10g, 15g, ( ) 5g 3,, 10 19 20 21 90, 38%, 73 % 22 6. 1 10,,,,,,1,, 3 23 7. 1 30,,, 13,, 6 24,,

112,,,,,,, 2 25 8. 2 1,,,, 2,,,,,, 5 2,,,, 7 2 6,,,,,,, 1,3, 25 9.,, 3S,, 4, 2, 14 1,,, 2 7 10. 28 11. 12g, 9g, 1 5, 2 9 12. 1 3,,6 3 0 1, 3,,,, 3, 31 1, 4, 32, 33, 3 4, 7 3 5 1 : ( )6g, 10g, 12g, 20g ( ), 11, 3, 5, 36 12g, 3g1 5 29, 13. 9g, 1g, 1, 3 14 12g, ( ) 10g, ( ) 20 g,,, ( ) 1 2, 8,, 36 9g, 12g, 1 7 37 14. 12g, 6g, 1,, 5, 29 9g, 1 3 37 1,, 3,, 20 2, 6 15. 18, 6, 7, 3, 2 : ; ; ;