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4 Anticonvulants NSAIDsAntibiotics Pharmacogenomics genetic polymorphism 30 (Pharmacogenomics):

Academia Sinica 93 2002 MALDI-TOF MALDI-TOF(Matrix-assisted laser desorption ionization time-of-flight) 1. DNA2. 3. DNA 4. 5.DNA Carbamazepine 5

41Nature carbamazepine 44 carbamazepine 101carbamazepine 44 HLA-B*15023% HLA HLA-B 6

Academia Sinica 93 HLA-B HLA-B class I HLA-B 40HLA- B*1502() 50040 2500 carbamazepine HLA-B*1502 carbamazepine HLA-B*1502 carbamazepine 7

8 Nethyl-N-nitrosourea ENU ENU ENU ENU

Academia Sinica 93 ENU ENU a. b. * Leu+Ile( ) ( ) 9

ENU Valine, Leucine, Isoleucine... BCKD 10

Academia Sinica 93 Bcat2DNA (1) DNA (2)DNA(3) DNA 2004 Journal of Clinical InvestigationVanderbilt University Dr. Arnold W. StraussDr. Strauss ENU David Millington (NSC 91-3112-P-001-017-Y) 11

12 DNA RNA RNA RNA RNA RNA A B (TNPO3)SR Ran

Academia Sinica 93 TNPO3 SR p62 Ran SR RNA RNA RNA RNA TNPO3SR(RBM4)Ran 13

RNA RNA RNA RNA RNA RBM4SRASFRNA SR(Pnn)(RNPS1)RNA EJCRNA RNA RNA 21 14

Academia Sinica 93 CIA2Tic40 Toc159 Toc75 ATPGTP 15

Toc75 Toc159 1 CIA1 ATP GTP ATP (A)(B) cia1(c) cia1 (A)(B)cia2 (A)(B)tic40 1 cm GTP 2 CIA2 RNA CIA2 3 Tic40 Tic40 Tic40 16

Academia Sinica 93 5 DNA DNA 17

18 CPAP, Protein 4.1, Aurora CPAP CPAP CPAP CPAP CPAP DNA CPAP

Academia Sinica 93 CPAP CPAP CPAP CPAP CPAPCPAP CPAP CPAP CPAP CPAP112 CPAPN Taxol-stabilized CPAP112FACS ACPAPSub-G1 BTUNEL CDNAC D Taxol 19

20 112CPAP Taxol-stabilized112 2004112 1121/ C CPAP CPAP 112 CPAP CPAP CPAP112 A-C CPAP D-F CPAP C A, DCPAP B (A, B) (D, E) C, F

80 90 21 1999 F + HD 0.25 / 3 / H D F + HD HF + D1a F + HD DF + H1b D 1b QM:quantum mechanics QCT:quasi-classical trajectory 22

Academia Sinica 93 1 / H 1a 1 / 1b QM, Resonance ( 2 ) 20 H F D 2001 F + CH 4 CH 3 + HF CH 3 CCD 5 23

X X abc F + CH 4 5.3 / 2.7 / 0.5 / CH 3 v = 0 ab HF 0.5 / c HFv = 2 0.5 / CH 3 CH F-H-CH 3 H F CH 3 3 F + 24

(a) (b) (c) Academia Sinica 93 CH 3 (CH 3 ) (HF) ( ) CH 3 HF CH 4 12 12 F + CH 4 H H CH 3 C-H ; F-H-CH 3 HF F + HD F + CH 4 molecular pair dance 25

26 Cowan Reines1956 250 neutrino oscillationstandard Model 2002 TEXONO TEXONO

Academia Sinica 93 19801990 Fermilab BrookhavenCERN) KEK 1996 1997 TEXONOTaiwan Experiment On NeutrinO 28 27

2001 2002 neutrino magnetic momentsneutrino radiative decays 20034Physical Review Letters American Institute of Physics Science Magazine coherent scattering 28

Academia Sinica 93 SPring8 29

electroencephalography magnetoencephalographymagnetic resonance imaging Dr. Paul C. Lauterbur Sir Peter Mansfield 2003 2001 (a)(b)t1t2 3D(c)3D,(d)() 3D(e)() 30

T2 () (a)(b) (c) 5 1236T2 (d) (e) (f) () 3D Academia Sinica 93 (scanning sequence T1T2 3D 3D mesh (a)3d(b)3d 3D3D(a) (b)(a) (a)(b) (a)(b) 3D 3D 31

(a)(b)(c) (e)t(f) t(g) (h)(i) (k) diffusionperfusionblood oxygenation level dependant functional MRI SPM sensitivityfalse alarm experimental runs) SPM ( ) 32

Academia Sinica 93 (a)(b) (c) (d) taskreproducibility 2003 New Perspective in fmri Journal of Cognitive Neuroscience (a)(b)(erp-image) (trial) (c)() O1 ( ) 80 33

event-related potential phase resetting John Aston 34

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Academia Sinica 93 GIS http://ccts.ascc.net 47

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Academia Sinica 93 http://thcts.ascc.net WebGIS WebGIS WebGIS (Mark-Up) 49

50 WebGIS 19041920 WebGIS ˇˇ

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Academia Sinica 93 G. Gushue-Taylor, 1883-1954 1911-1954 53

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