103 1 3~7 100% 8~14 90% 1 21 Transmissible Gastroenteritis virus TGEV Porcine Epidemic Diarrhea virus PEDV Porcine Rotavirus PRV 100% RT-PCR 2 18 2014 6
PED Membrane protein gene M gene M 2013 100% CV-777 98.1% 11 3 9 31 75.61% 31/41 3 4 219,756 5 1971 1976 1978 CV-777 PED 1970 1980 VETERINARIAN NEWSLETTER NO.9 19
1982 1973 PED PEDV NidoviralesCoronavirinae Alphacoronavirus TGEV PRCV HEV Torovirus ToV 60 160 nm Spike protein S 6 PEDV RNA 28,000 2/3 15~16 1/3 220 kda 29-36 kda Membrane protein M Envelope protein E 47 kda Nucleocapsid protein N PED PED PED SM N CV-777 2a PEDV M 100% 20 2014 6
PEDV 2012 AH/2012/China PED Oral-fecal pathway PED All-in-all-out PEDV 60 7 4 PEDV 1 Stroke Environ, Tek-Trol Virkon Clorox 1% Formalin USDA 100 32 1-2% 1 Stroke Environ Tek- Trol VETERINARIAN NEWSLETTER NO.9 21
PEDV PEDV PEDV PED feedback PEDV PEDV PEDV PED PED CV-777 DR-13 KPED-9 Vero cell 100 93 SM98P5 DR-13 1x107 TCID 50 /dose 13% 22 2014 6
100% P-5V CV-777 DR-13 CV-777 PEDV PED PED PED SOP VETERINARIAN NEWSLETTER NO.9 23
24 2014 6
18 100% 100% 100% 100% 100% 100% 16 14 87.50% 87.50% 80% 12 10 8 6 4 2 0 60% 50% 40% 40% 20% 0% 14 12 10 8 6 4 2 0 VETERINARIAN NEWSLETTER NO.9 25
100,000 90,000 85,061 91,532 1,000 900 80,000 800 70,000 700 60,000 50,000 40,000 30,000 32,853 308 383 52,927 315 600 500 400 300 20,000 10,000 0 144 7,529 8,555 39 34 200 100 0 26 2014 6