1 2 13 14 16 19 22 22 24 28 30 31 33 10 35 36

7,885

1 2 13 14 16 19 22 22 24 28 30 31 33 10 35 36

QOL 53 15 7885 2 15 35 129 623 7000 2 50 QOL

53 15 2003 4 12 20 20 12,345 7,885 63.9% 1 7885 48 5 48 7,837 10,200 71.3% 7,272 7,235 2,145 613 602 28.6% 2 7,837 1

6 7 1 (%) 1. 20 29 110 (1.4%) 2. 30 39 435 (5.6%) 3. 40 49 1,184 (15.1%) 4. 50 59 2,036 (26.0%) 5. 60 69 2,369 (30.2%) 6. 70 79 1,427 (18.2%) 7. 80 89 125 (1.6%) 8. 90 99 4 (0.1%) 147 (1.9%) 7,837 (100.0%) 40 91.2% 60 69 2 (%) 1. 4 (0.1%) 2. 271 (3.5%) 3. 749 (9.6%) 4. 230 (2.9%) 5. 1,046 (13.3%) 6. 35 (0.4%) 7. 1,055 (13.5%) 8. 255 (3.3%) 9. 87 (1.1%) 10. 102 (1.3%) 11. 76 (1.0%) 12. 120 (1.5%) 13. 29 (0.4%) 14. 100 (1.3%) 15. 498 (6.4%) 16. 156 (2.0%) 17. 1,904 (24.3%) 18. 302 (3.9%) 19. 14 (0.2%) 20. 90 (1.1%) 21. 162 (2.1%) 22. 32 (0.4%) 23. 8 (0.1%) 24. 30 (0.4%) 25. 197 (2.5%) 26. 102 (1.3%) 183 (2.3%) 7,837 (100.0%) 2

3 (%) 1. 1,852 (23.6%) 2. 5,744 (73.3%) 241 (3.1%) 7,837 (100.0%) 1/4 5 10 3-1 1,852 (%) 1. 85 (4.6%) 2. 45 (2.4%) 3. 498 (26.9%) 4. 24 (1.3%) 5. 88 (4.8%) 6. 21 (1.1%) 7. 149 (8.0%) 8. 455 (24.6%) 9. 16 (0.9%) 10. 26 (1.4%) 11. 42 (2.3%) 12. 68 (3.7%) 13. 27 (1.5%) 14. 11 (0.6%) 15. 31 (1.7%) 16. 36 (1.9%) 17. 120 (6.5%) 18. 41 (2.2%) 19. 0 20. 18 (1.0%) 21. 32 (1.7%) 22. 433 (23.4%) 23. 271 (14.6%) 24. 15 (0.8%) 25. 29 (1.6%) 26. 46 (2.5%) 27. 2 (0.1%) 28. 60 (3.2%) 26 (1.4%) 4 (%) 1. 2,820 (36.0%) 2. 4,758 (60.7%) 3. 135 (1.7%) 124 (1.6%) 7,837 (100.0%) 3 3

7,837 (%) 1. 6,013 (76.7%) 2. 1,968 (25.1%) 3. 4,601 (58.7%) 4. 2,374 (30.3%) 5. 121 (1.5%) 171 (2.2%) 6 (%) 1. 4,412 (56.3%) 2. 2,649 (33.8%) 3. 4. 412 (5.3%) 188 (2.4%) 5. 16 (0.2%) 160 (2.0%) 7,837 (100.0%) 7 7,837 (%) 1. 3,770 (48.1%) 2. 4,144 (52.9%) 3. 2,277 (29.1%) 4. 1,608 (20.5%) 5. 628 (8.0%) 6. 2,752 (35.1%) 7. 2,949 (37.6%) 8. 180 (2.3%) 873 (11.1%) 4

8 7 a (%) 1. 1,570 (20.0%) 2. 5,036 (64.3%) 1,231 (15.7%) 7,837 (100.0%) 9 8 2 5,036 (%) (%) (%) 1. 2,976 (59.1%) 579 (11.5%) 11 (0.2%) 2. 1,138 (22.6%) 193 (3.8%) 5 (0.1%) 3. 817 (16.2%) 144 (2.9%) 4 (0.1%) 4. 272 (5.4%) 54 (1.1%) 5 (0.1%) 5. 487 (9.7%) 53 (1.1%) 1 (0.0%) 6. 120 (2.4%) 17 (0.3%) 0 7. 1,288 (25.6%) 156 (3.1%) 9 (0.2%) 8. 331 (6.6%) 49 (1.0%) 3 (0.1%) 9. 111 (2.2%) 7 (0.1%) 1 (0.0%) a. 49 (1.0%) 12 (0.2%) 1 (0.0%) b. 24 (0.5%) 6 (0.1%) 2 (0.0%) c. 39 (0.8%) 10 (0.2%) 1 (0.0%) 878 (17.4%) 878 (17.4%) 878 (17.4%) (%) (%) 1. 18 (0.4%) 7 (0.1%) 2. 27 (0.5%) 4 (0.1%) 3. 15 (0.3%) 5 (0.1%) 4. 8 (0.2%) 2 (0.0%) 5. 4 (0.1%) 5 (0.1%) 6. 7 (0.1%) 9 (0.2%) 7. 24 (0.5%) 4 (0.1%) 8. 5 (0.1%) 0 9. 1 (0.0%) 4 (0.1%) a. 4 (0.1%) 3 (0.1%) b. 4 (0.1%) 7 (0.1%) c. 2 (0.0%) 6 (0.1%) 878 (17.4%) 878 (17.4%) 5

b (%) 1. 1,099 (14.0%) 2. 4,266 (54.4%) 2,472 (31.5%) 7,837 (100.0%) 4,266 (%) (%) (%) 1. 2,279 (53.4%) 296 (6.9%) 6 (0.1%) 2. 1,076 (25.2%) 127 (3.0%) 2 (0.0%) 3. 653 (15.3%) 79 (1.9%) 4 (0.1%) 4. 212 (5.0%) 35 (0.8%) 2 (0.0%) 5. 876 (20.5%) 74 (1.7%) 1 (0.0%) 6. 257 (6.0%) 18 (0.4%) 1 (0.0%) 7. 1,489 (34.9%) 167 (3.9%) 16 (0.4%) 8. 471 (11.0%) 54 (1.3%) 3 (0.1%) 9. 102 (2.4%) 8 (0.2%) 1 (0.0%) a. 65 (1.5%) 12 (0.3%) 2 (0.0%) b. 21 (0.5%) 6 (0.1%) 1 (0.0%) c. 51 (1.2%) 14 (0.3%) 0 792 (18.6%) 792 (18.6%) 792 (18.6%) (%) (%) 1. 14 (0.3%) 3 (0.1%) 2. 17 (0.4%) 3 (0.1%) 3. 9 (0.2%) 3 (0.1%) 4. 9 (0.2%) 1 (0.0%) 5. 10 (0.2%) 3 (0.1%) 6. 11 (0.3%) 8 (0.2%) 7. 33 (0.8%) 5 (0.1%) 8. 9 (0.2%) 2 (0.0%) 9. 1 (0.0%) 6 (0.1%) a. 9 (0.2%) 5 (0.1%) b. 4 (0.1%) 4 (0.1%) c. 1 (0.0%) 6 (0.1%) 792 (18.6%) 792 (18.6%) 6

c (%) 1. 1,276 (16.3%) 2. 3.526 (45.0%) 3.035 (38.7%) 7,837 (100.0%) 3,526 (%) (%) (%) 1. 1,840 (52.2%) 236 (6.7%) 6 (0.2%) 2. 826 (23.4%) 96 (2.7%) 1 (0.0%) 3. 466 (13.2%) 61 (1.7%) 5 (0.1%) 4. 156 (4.4%) 24 (0.7%) 5 (0.1%) 5. 568 (16.1%) 56 (1.6%) 0 6. 196 (5.6%) 15 (0.4%) 0 7. 1,214 (34.4%) 133 (3.8%) 1 (0.0%) 8. 262 (7.4%) 31 (0.9%) 5 (0.1%) 9. 87 (2.5%) 9 (0.3%) 0 a. 38 (1.1%) 9 (0.3%) 1 (0.0%) b. 22 (0.6%) 6 (0.2%) 3 (0.1%) c. 49 (1.4%) 16 (0.5%) 1 (0.0%) 692 (19.6%) 692 (19.6%) 692 (19.6%) (%) (%) 1. 17 (0.5%) 3 (0.1%) 2. 13 (0.4%) 3 (0.1%) 3. 8 (0.2%) 1 (0.0%) 4. 3 (0.1%) 4 (0.1%) 5. 4 (0.1%) 2 (0.1%) 6. 8 (0.2%) 4 (0.1%) 7. 31 (0.9%) 7 (0.2%) 8. 7 (0.2%) 0 9. 0 9 (0.3%) a. 9 (0.3%) 8 (0.2%) b. 4 (0.1%) 5 (0.1%) c. 3 (0.1%) 10 (0.3%) 692 (19.6%) 692 (19.6%) 7

10 11 (%) 1. 2029 45 (0.6%) 2. 3039 258 (3.3%) 3. 4049 802 (10.2%) 4. 5059 1,809 (23.1%) 5. 6069 2,395 (30.6%) 6. 7079 2,073 (26.5%) 7. 8089 272 (3.5%) 8. 9099 6 (0.1%) 177 (2.3%) 7,837 (100.0%) 40 93.950 83.6 12 (%) 1. 3,531 (45.1%) 2. 4,220 (53.8%) 86 (1.1%) 7,837 (100.0%) 8

13 13-1 (%) 1. 429 (5.5%) 2. 6,252 (79.8%) 3. / 1011 (12.9%) 145 (1.9%) 7,837 (100.0%) 13-2 =7,837 1. 2. () 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 8.4% 1 13-3 (%) 1. 138 (1.8%) 2. 417 (5.3%) 3. 228 (2.9%) 4. 401 (5.1%) 5. 5,023 (64.1%) 6. 268 (3.4%) 7. 33 (0.4%) 1,329 (17.0%) 7,837 (100.0%) 64.1% 15.1% 9

14 14-1 (%) (%) 1. 390 (5.0%) 1. 291 (3.7%) 2. 372 (4.7%) 2. 306 (3.9%) 3. 297 (3.8%) 3. 238 (3.0%) 4. 291 (3.7%) 4. 202 (2.6%) 5. 1,335 (17.0%) 5. 749 (9.6%) 6. 372 (4.7%) 6. 251 (3.2%) 7. 798 (10.2%) 7. 532 (6.8%) 8. 40 (0.5%) 8. 29 (0.4%) 9. 1,135 (14.5%) 9. 1,435 (18.3%) 10. 14 (0.2%) 10. 5 (0.1%) 11. 1171 (14.9%) 11. 2158 (27.5%) 12. 140 (1.8%) 12. 122 (1.6%) 1,482 (18.9%) 1,519 (19.4%) 7,837 (100.0%) 7,837 (100.0%) 50 69 14-2 (%) (%) 1. 216 (2.8%) 1. 171 (2.2%) 2. 186 (2.4%) 2. 116 (1.5%) 3. 3. 572 (7.3%) 319 (4.1%) 4. 361 (4.6%) 4. 222 (2.8%) 5. 610 (7.8%) 5. 408 (5.2%) 6. 676 (8.6%) 6. 468 (6.0%) 7. 475 (6.1%) 7. 296 (3.8%) 8. 483 (6.2%) 8. 382 (4.9%) 9. 274 (3.5%) 9. 224 (2.9%) 3,984 (50.8%) 5,231 (66.7%) 7,837 (100.0%) 7,837 (100.0%) 10

14-3 (%) (%) 1. 1,249 (47.6%) 1. 694 (68.0%) 2. 229 (8.7%) 2. 79 (7.7%) 3. 799 (30.5%) 3. 58 (5.7%) 4. 111 (4.2%) 4. 135 (13.2%) 5. 237 (9.0%) 5. 41 (4.0%) 2,625 (100.0%) 6. 14 (1.4%) 1,021 (100.0%) 14-3 3,646 2,625 1,021 34.7% 30.7% 15 (%) 1. 120 448 (5.7%) 2. 120300 1,743 (22.2%) 3. 300400 1,300 (16.6%) 4. 400500 800 (10.2%) 5. 500600 612 (7.8%) 6. 600800 810 (10.3%) 7. 8001,000 586 (7.5%) 8. 1,0002,000 549 (7.0%) 9. 2,000 89 (1.1%) 900 (11.5%) 7,837 (100.0%) 400 44.5% 120 29 330 39 340 49 450 59 560 670 780 890 69 79 89 99 1. 120 7 16 25 75 135 145 28 17 448 2. 120300 14 28 75 237 707 578 69 1 34 1,743 3. 300400 7 31 61 178 486 462 55 20 1,300 4. 400500 5 45 68 157 237 248 28 12 800 5. 500600 3 36 83 174 171 124 11 10 612 6. 600800 3 36 184 284 176 100 11 16 810 7. 8001,000 1 17 116 275 111 54 5 1 6 586 8. 1,0002,000 2 13 110 231 102 75 9 7 549 9. 2,000 1 14 34 24 15 1 89 3 35 66 164 246 272 56 4 54 900 45 258 802 1,809 2,395 2,073 272 6 177 7,837 11

16 A. (%) 1. 50 3,688 (47.1%) 2. 50100 892 (11.4%) 3. 100150 318 (4.1%) 4. 150200 131 (1.7%) 5. 200250 52 (0.7%) 6. 250300 36 (0.5%) 7. 300350 26 (0.3%) 8. 350400 4 (0.1%) 9. 400450 4 (0.1%) 10. 450500 2 (0.0%) 11. 500550 3 (0.0%) 12. 550600 2 (0.0%) 13. 600650 4 (0.1%) 14. 650700 1 (0.0%) 15. 700750 2 (0.0%) 17. 800850 2 (0.0%) 18. 850900 1 (0.0%) 23. 1,0001,150 1 (0.0%) 30. 1,4501,500 1 (0.0%) 2,667 (34.0%) 7,837 (100.0%) 50 60 69 16 D (%) 1. 50 1,173 (15.0%) 2. 50100 177 (2.3%) 3. 100150 81 (1.0%) 4. 150200 34 (0.4%) 5. 200250 22 (0.3%) 6. 250300 3 (0.0%) 7. 300350 11 (0.1%) 8. 350400 4 (0.1%) 9. 400450 2 (0.0%) 12. 550600 1 (0.0%) 16. 750800 1 (0.0%) 6,328 (80.7%) 7,837 (100.0%) 12

7885 34 25952 15 35 129 623 3-1 1 3-1 13-3-3-6 - 13-1 13-2 13-3 13-3-1 13-3-2 13-3-3 13-3-3-1 13-3-3-2 13-3-3-3 13-3-3-4 13-3-3-5 13-3-3-6 13

4-1 4-1 82 0.8% 22 0.3% 17 0.2% 121 0.5% 85 0.8% 93 1.2% 17 0.2% 195 0.8% 669 6.4% 655 8.3% 414 5.5% 1,738 6.7% 76 0.7% 29 0.4% 53 0.7% 158 0.6% 110 1.0% 131 1.7% 50 0.7% 291 1.1% 0-1 0.0% 1 0.0% 2 0.0% 1 0.0% 0-2 0.0% 3 0.0% 5 0.0% 24 0.3% 23 0.3% 52 0.2% 128 1.2% 280 3.5% 172 2.3% 580 2.2% 96 0.9% 49 0.6% 11 0.1% 156 0.6% 125 1.2% 2,000 25.3% 1,790 23.7% 3,915 15.1% 6,417 61.1% 2,940 37.3% 3,267 43.2% 12,624 48.6% 465 4.4% 343 4.3% 332 4.4% 1,140 4.4% 625 6.0% 575 7.3% 855 11.3% 2,055 7.9% 1,617 15.4% 748 9.5% 557 7.4% 2,922 11.3% 10,501 100.0% 7,890 100.0% 7,561 100.0% 25,952 100.0% 14

4-2 4-1 4-2 61.1% 37.3% 43.2% 1.2% 25.3% 23.7% 10501 7,890 7,561 25,952 1 3 467 2 15

5 4,911 7,182 1.5 14 8 10 5-1 5-1 16

3 6 5-2 5-2 546 964 1.8 17

18

19

20

24 21

7 4 48.6 12,624 4,033 3,087 304 438 427 2,177 606 2,116 561 6,417 2,940 3,267 1 2 20 1,915 603 569 :1,736 300 80 1,674 287 216 4 663 1,304 2,066 249 196 116 22

2 14 4-1 3,915 15.1 3 14 4-1 2,922 11.3% 2,358 470 240 323 189 4 14 4-1 2,055 7.9 506 255 575 336 32 60 5 14 4-1 1,140 4.4% 360 380 116 75 23

1,904 1,055 1,046 749 498 302 7-1 7-1 7-1 6 24

7-1 10 25 25

1,904 7,764 1 1 1,266 16.4% 227 409 630 2 1 3 969 12.5% 1,055 3,100 2 516 16.6% 109 53 44 35 26

1,046 3,098 2 639 20.6% 203 98 95 749 2,152 1 1,180 54.8% 498 2,022 2 3 292 14.4% 247 302 721 2 129 17.9% 43 11 8 32 10 27

7-2 7-2 1,852 6,933 5,744 18444 3,398 49.0% 8,924 48.4% 7-3 16.2% 7-3 1 28

7-4 7-4 5 5 10 10 510 5 510 29

7,837 3,531 4,220 873 606 9,583 16,074 3.6 4.4 7-5 7-5 1 4,923 7,572 5 2 154 1.6% 351 2.2% 2 97 1.0% 606 3.8% 38 0.4% 518 3.2% 30

2002 9 2003 12 10230 8-1 2,548 24.9% 121 0.5% 530 5.2% 195 0.8% 2,053 20.1% 1,738 6.7% 243 2.4% 158 0.6% 2,262 22.1% 291 1.1% 42 0.4% 2 0.0% 141 1.4% 3 0.0% 250 2.4% 52 0.2% 83 0.8% 580 2.2% 97 0.9% 156 0.6% 313 3.1% 3,915 15.1% 8,562 83.7% 7,211 27.8% 246 2.4% 12,624 48.6% 15 0.1% 1,140 4.4% 651 6.4% 2,055 7.9% 46 0.4% 2,922 11.3% 958 9.4% 18,741 72.2% 710 6.9% 0 0.0% 10,230 100.0% 25,952 100.0% 8-1 31

8-1 8-1 8-1 83.7% 32

9 33

34

10 QOL 3 7 2 24 35

Yamaguchi Ken Isobe Hiroshi Saito Satoshi Mochizuki Izumi Sato Haruhiko Nagai Yoshikiyo Kikuchi Atsushi Shimizu Chiyo Okura Hisanao Tanemura Kenjiro Sekiguchi Isao Tsukagoshi Toshio Kobayashi Kunihiko Kato Makoto Kano Nobuyasu Shiba Mitsutoshi Tanaka Masashi Yusa Toshikazu Yaguchi Noboru Watanabe Satoshi Arakawa Yasuyuki Koike Makiko Sasaki Tsuneo Hasegawa Toshihiko () Hayashi Izumi Maruguchi Misae Kondo Mayumi Egami Kaku Katahira Yoshie Yamashita Kosuke Tsuchiya Yoshiaki Kaji Masahide Kawaura Yukimitsu Hosokawa Osamu 36

Amana Koji Hamaguchi Keiko Saito Etsuko Ishikawa Mutsumi Okuhara Hidemori Kishimoto Norifumi Fujii Yuji Horikoshi Yasuo Ishibashi Miwako Nagai Hiroiazu Sakai Takashi Sakakura Kiwamu Idomoto Mutsum Yabana Tadashi Kawakami Kenzo Ono Yuko Okada Keiji Kogire Masashi Sato Ayako Sawamura Toshiro Tanaka Katsuyuki Tanio Yoshiro Tabuse Katsuyoshi Yoshikawa Kiyoshi Yoshida Yoshiro Obayashi Kayoko Yoden Eisaku Kakikawa Fusako Ando Yoshiko Tsutsui Kazushige Shabana Masanobu Yoshida Kotaro Watanabe Yoichi Kimura Hideyuki Koseki Masato Hirokawa Yumiko Yoshii Yoshimasa Takai Shigeharu Shirakawa Kazutoyo Saeki Hideyuki Sawada Shigeki Horimi Tadashi 37

Ono Shinji Koufuji Kikuo Sadamura Shingo Takahashi Ikuo Noguchi Kazunori Mitsuyama Shoshu Kusumoto Tetsuya Yano Tokujiro Kohara Norihiro Hara Shinsuke Kai Hidenobu Akebono IDEA FOUR &VOL-Net AiAi () Ostomy Tsutsujino Dongurino Nozomino Hospice Care Hohoemino Asunaro B-8 HCRM NPO Orange Tea NPO Rakkan Net Peer 38

11-20 Yamaguchi Ken Shinkai Tetsu Mori Fumiko Yoshimura Kimio Endo Hisashi 13-3 Yamaguchi Ken Koinuma Nobuo Yamaguchi Naohito Kakikawa Fusako Ayuzawa Junko Horiuchi Tomoko Muramatsu Harumi Yoshida Ayako Ito Hajime 39

1 20 13 14 34 50 53

2 20 1 1,915 1,304 2,066 4,033 2 1,736 603 569 3,087 3 1,674 495 333 2,177 4 663 300 258 2,116 5 360 287 216 673 6 344 235 207 606 7 293 219 194 561 8 249 196 177 506 13 9 242 170 157 501 10 196 164 140 493 11 191 156 139 470 12 179 154 133 431 13 172 152 124 429 14 164 137 116 423 15 139 132 111 412 16 135 132 108 380 17 133 126 103 360 18 115 112 96 357 19 111 103 93 336 20 93 informed consent 99 80 323

3 1 1-1-2 3 1-2-1 1-2-2 2 2-1-2 2-1-3 C 3 2-2-2 4 2-3-1 1 2-3-2 3 3-1-1 10 14

3-1-2 2 3-1-3? 3-1-4 3 3-1-5 3-1-6 3 3-2-1 1 3-2-2 4 4-1-1, 4-1-2 15

4-2-1 4-2-2 5 ICinformed-consentsecond opinion 5-1-1 2 5-2-1 5-2-2 5-3-1? 6 6-1-1 6-2-1 7 7-1-1 7-1-2 16

8 8-1-1 8-1-2 5 10 8-2-1 2 3 9 9-1-1 9-1-2 3 1 9-1-3 3-4 9-1-4 9-2-1? 17

10 10-1-1 3 1 MRI 10-1-2 10-2-1 10-2-2 1 1 11 11-1-1 11-1-2 11-1-3 34 11-1-4 18

11-1-5 11-1-6 12 1 2 2030 11-1-7 11-1-8 20 1 1 10 6 11-1-9 1 1 1 11-1-10 1 11-1-11? 19

11-1-12 11-1-13 1? 11-1-14? 11-1-15 11-1-16 2 11-1-17 3 4 2 20

11-1-18 11-1-19 11-1-20 11-1-21 1/3 10 11-1-22 1/3 15 3 180 23 21

11-1-23 ILEUS 11-1-24 ILEUS 11-1-25 Casodex 3 11-1-26 1 2 12 11-1-27 11-1-30 11-1-31 11-1-32 22

11-1-33 30 1 11-1-34 11-1-35 11-2-1 keloid 3 39 3 2 7 MRSA Nolvadex 23

11-2-3 2 11-2-4 3 11-2-5 11-3-1 3 19 100 11-3-2 1 24

12 12-1-1 12-1-2 12-1-3 12-2-1 12-2-2 25

12-3-1 12-3-2 2 12-4-1 12-4-2 12-4-3 2 13 13-1-1 26

13-1-2 13-2-1 13-3-1 13-3-2 13-3-3 27

14 14-1-1,, 14-1-2 10 14-1-3 14-1-4 14-1-5 14-2-1 14-2-2 14-2-3 14-2-4 14-2-5 15 15-1-1 28

15-1-2 15-1-3 15-1-4 15-1-5 15-1-6 15-1-7 15-1-8 2 29

15-1-9,, 15-2-1 70 2 1 2 1 1 15-2-2 16 30

15-2-3 15-2-4 HLA 31

15-2-5 15-2-6 15-2-7 1 1 2 15-2-8 4 32

15-2-9 2 15-2-11 33

1 (%) (%) 1. 20 29 81 (1.1%) 29 (4.8%) 2. 30 39 334 (4.6%) 101 (16.8%) 3. 40 49 986 (13.6%) 198 (32.9%) 4. 50 59 1,866 (25.8%) 170 (28.2%) 5. 60 69 2,293 (31.7%) 76 (12.6%) 6. 70 79 1,410 (19.5%) 17 (2.8%) 7. 80 89 124 (1.7%) 1 (0.2%) 8. 90 99 4 (0.1%) 0 137 (1.9%) 10 (1.7%) 7,235 (100.0%) 602 (100.0%) 2 (%) (%) 1. 3 (0.0%) 1 (0.2%) 2. 270 (3.7%) 1 (0.2%) 3. 735 (10.2%) 14 (2.3%) 4. 226 (3.1%) 4 (0.7%) 5. 1,018 (14.1%) 28 (4.7%) 6. 33 (0.5%) 2 (0.3%) 7. 1,027 (14.2%) 28 (4.7%) 8. 250 (3.5%) 5 (0.8%) 9. 84 (1.2%) 3 (0.5%) 10. 97 (1.3%) 5 (0.8%) 11. 70 (1.0%) 6 (1.0%) 12. 118 (1.6%) 2 (0.3%) 13. 28 (0.4%) 1 (0.2%) 14. 100 (1.4%) 0 15. 392 (5.4%) 106 (17.6%) 16. 113 (1.6%) 43 (7.1%) 17. 1,663 (23.0%) 241 (40.0%) 18. 292 (4.0%) 10 (1.7%) 19. 13 (0.2%) 1 (0.2%) 20. 89 (1.2%) 1 (0.2%) 21. 93 (1.3%) 69 (11.5%) 22. 32 (0.4%) 0 23. 8 (0.1%) 0 24. 29 (0.4%) 1 (0.2%) 25. 186 (2.6%) 11 (1.8%) 26. 97 (1.3%) 5 (0.8%) 169 (2.3%) 14 (2.3%) 7,235 (100.0%) 602 (100.0%) 34

3 (%) (%) 1. 1,730 (23.9%) 122 (20.3%) 2. 5,279 (73.0%) 465 (77.2%) 226 (3.1%) 15 (2.5%) 7,235 (100.0%) 602 (100.0%) 3-1 1,730 122 (%) (%) 1. 78 (4.5%) 7 (5.7%) 2. 43 (2.5%) 2 (1.6%) 3. 470 (27.2%) 28 (23.0%) 4. 24 (1.4%) 0 5. 85 (4.9%) 3 (2.5%) 6. 20 (1.2%) 1 (0.8%) 7. 140 (8.1%) 9 (7.4%) 8. 437 (25.3%) 18 (14.8%) 9. 15 (0.9%) 1 (0.8%) 10. 25 (1.4%) 1 (0.8%) 11. 40 (2.3%) 2 (1.6%) 12. 68 (3.9%) 0 13. 23 (1.3%) 4 (3.3%) 14. 11 (0.6%) 0 15. 29 (1.7%) 2 (1.6%) 16. 31 (1.8%) 5 (4.1%) 17. 103 (6.0%) 17 (13.9%) 18. 40 (2.3%) 1 (0.8%) 19. 0 0 20. 17 (1.0%) 1 (0.8%) 21. 22 (1.3%) 10 (8.2%) 22. 401 (23.2%) 32 (26.2%) 23. 249 (14.4%) 22 (18.0%) 24. 14 (0.8%) 1 (0.8%) 25. 27 (1.6%) 2 (1.6%) 26. 39 (2.3%) 7 (5.7%) 27. 2 (0.1%) 0 28. 49 (2.8%) 11 (9.0%) 24 (1.4%) 2 (1.6%) 35

4 (%) (%) 1. 2,674 (37.0%) 146 (24.3%) 2. 4,380 (60.5%) 378 (62.8%) 3. 69 (1.0%) 66 (11.0%) 112 (1.5%) 12 (2.0%) 7,235 (100.0%) 602 (100.0%) 5 7,235 602 (%) (%) 1. 5,520 (76.3%) 493 (81.9%) 2. 1,906 (26.3%) 62 (10.3%) 3. 4,163 (57.5%) 438 (72.8%) 4. 2,140 (29.6%) 234 (38.9%) 5. 82 (1.1%) 39 (6.5%) 163 (2.3%) 8 (1.3%) 6 1. 2. 3. (%) (%) 4,037 (55.8%) 375 (62.3%) 2,447 (33.8%) 202 (33.6%) 400 (5.5%) 12 (2.0%) 4. 187 (2.6%) 1 (0.2%) 5. 14 (0.2%) 2 (0.3%) 150 (2.1%) 10 (1.7%) 7,235 (100.0%) 602 (100.0%) 36

7 =7,235 =602 (%) (%) 1. 3,389 (46.8%) 381 (63.3%) 2. 3,731 (51.6%) 413 (68.6%) 3. 2,049 (28.3%) 228 (37.9%) 4. 1,419 (19.6%) 189 (31.4%) 5. 484 (6.7%) 144 (23.9%) 6. 2,543 (35.1%) 209 (34.7%) 7. 2,623 (36.3%) 326 (54.2%) 8. 147 (2.0%) 33 (5.5%) 848 (11.7%) 25 (4.2%) 37

8 7 a (%) (%) 1. 1,461 (20.2%) 109 (18.1%) 2. 4,585 (63.4%) 451 (74.9%) 1,189 (16.4%) 42 (7.0%) 7,235 (100.0%) 602 (100.0%) 9 8 2 4,585 451 (%) (%) 1. 2,760 (60.2%) 216 (47.9%) 2. 995 (21.7%) 143 (31.7%) 3. 760 (16.6%) 57 (12.6%) 4. 246 (5.4%) 26 (5.8%) 5. 404 (8.8%) 83 (18.4%) 6. 22 (0.5%) 98 (21.7%) 7. 1,182 (25.8%) 106 (23.5%) 8. 297 (6.5%) 34 (7.5%) 9. 85 (1.9%) 26 (5.8%) a. 45 (1.0%) 4 (0.9%) b. 24 (0.5%) 0 c. 36 (0.8%) 3 (0.7%) 789 (17.2%) 89 (19.7%) (%) (%) 1. 524 (11.4%) 55 (12.2%) 2. 167 (3.6%) 26 (5.8%) 3. 128 (2.8%) 16 (3.5%) 4. 47 (1.0%) 7 (1.6%) 5. 44 (1.0%) 9 (2.0%) 6. 3 (0.1%) 14 (3.1%) 7. 131 (2.9%) 25 (5.5%) 8. 36 (0.8%) 13 (2.9%) 9. 7 (0.2%) 0 a. 8 (0.2%) 4 (0.9%) b. 5 (0.1%) 1 (0.2%) c. 6 (0.1%) 4 (0.9%) 789 (17.2%) 89 (19.7%) 38

a (%) (%) 1. 5 (0.1%) 6 (1.3%) 2. 3 (0.1%) 2 (0.4%) 3. 4 (0.1%) 0 4. 3 (0.1%) 2 (0.4%) 5. 0 1 (0.2%) 6. 0 0 7. 6 (0.1%) 3 (0.7%) 8. 1 (0.0%) 2 (0.4%) 9. 1 (0.0%) 0 a. 0 1 (0.2%) b. 1 (0.0%) 1 (0.2%) c. 0 1 (0.2%) 789 (17.2%) 89 (19.7%) (%) (%) 1. 15 (0.3%) 3 (0.7%) 2. 24 (0.5%) 3 (0.7%) 3. 11 (0.2%) 4 (0.9%) 4. 4 (0.1%) 4 (0.9%) 5. 3 (0.1%) 1 (0.2%) 6. 4 (0.1%) 3 (0.7%) 7. 17 (0.4%) 7 (1.6%) 8. 3 (0.1%) 2 (0.4%) 9. 0 1 (0.2%) a. 2 (0.0%) 2 (0.4%) b. 3 (0.1%) 1 (0.2%) c. 1 (0.0%) 1 (0.2%) 789 (17.2%) 89 (19.7%) (%) (%) 1. 5 (0.1%) 2 (0.4%) 2. 3 (0.1%) 1 (0.2%) 3. 4 (0.1%) 1 (0.2%) 4. 2 (0.0%) 0 5. 5 (0.1%) 0 6. 5 (0.1%) 4 (0.9%) 7. 3 (0.1%) 1 (0.2%) 8. 0 0 9. 3 (0.1%) 1 (0.2%) a. 2 (0.0%) 1 (0.2%) b. 5 (0.1%) 2 (0.4%) c. 4 (0.1%) 2 (0.4%) 789 (17.2%) 89 (19.7%) 39

b (%) (%) 1. 1,038 (14.3%) 61 (10.1%) 2. 3,791 (52.4%) 475 (78.9%) 2,406 (33.3%) 66 (11.0%) 7,235 (100.0%) 602 (100.0%) 3,791 475 (%) (%) 1. 2,093 (55.2%) 186 (39.2%) 2. 952 (25.1%) 124 (26.1%) 3. 611 (16.1%) 42 (8.8%) 4. 191 (5.0%) 21 (4.4%) 5. 746 (19.7%) 130 (27.4%) 6. 62 (1.6%) 195 (41.1%) 7. 1,353 (35.7%) 136 (28.6%) 8. 418 (11.0%) 53 (11.2%) 9. 74 (2.0%) 28 (5.9%) a. 51 (1.3%) 14 (2.9%) b. 19 (0.5%) 2 (0.4%) c. 42 (1.1%) 9 (1.9%) 693 (18.3%) 99 (20.8%) (%) (%) 1. 270 (7.1%) 26 (5.5%) 2. 100 (2.6%) 27 (5.7%) 3. 73 (1.9%) 6 (1.3%) 4. 30 (0.8%) 5 (1.1%) 5. 61 (1.6%) 13 (2.7%) 6. 4 (0.1%) 14 (2.9%) 7. 136 (3.6%) 31 (6.5%) 8. 44 (1.2%) 10 (2.1%) 9. 6 (0.2%) 2 (0.4%) a. 12 (0.3%) 0 b. 4 (0.1%) 2 (0.4%) c. 9 (0.2%) 5 (1.1%) 693 (18.3%) 99 (20.8%) 40

b (%) (%) 1. 3 (0.1%) 3 (0.6%) 2. 1 (0.0%) 1 (0.2%) 3. 3 (0.1%) 1 (0.2%) 4. 1 (0.0%) 1 (0.2%) 5. 1 (0.0%) 0 6. 0 1 (0.2%) 7. 5 (0.1%) 11 (2.3%) 8. 3 (0.1%) 0 9. 1 (0.0%) 0 a. 2 (0.1%) 0 b. 0 1 (0.2%) c. 0 0 693 (18.3%) 99 (20.8%) (%) (%) 1. 10 (0.3%) 4 (0.8%) 2. 15 (0.4%) 2 (0.4%) 3. 6 (0.2%) 3 (0.6%) 4. 4 (0.1%) 5 (1.1%) 5. 8 (0.2%) 2 (0.4%) 6. 8 (0.2%) 3 (0.6%) 7. 26 (0.7%) 7 (1.5%) 8. 8 (0.2%) 1 (0.2%) 9. 1 (0.0%) 0 a. 4 (0.1%) 5 (1.1%) b. 3 (0.1%) 1 (0.2%) c. 1 (0.0%) 0 693 (18.3%) 99 (20.8%) (%) (%) 1. 2 (0.1%) 1 (0.2%) 2. 2 (0.1%) 1 (0.2%) 3. 2 (0.1%) 1 (0.2%) 4. 1 (0.0%) 0 5. 2 (0.1%) 1 (0.2%) 6. 6 (0.2%) 2 (0.4%) 7. 4 (0.1%) 1 (0.2%) 8. 1 (0.0%) 1 (0.2%) 9. 5 (0.1%) 1 (0.2%) a. 4 (0.1%) 1 (0.2%) b. 4 (0.1%) 0 c. 3 (0.1%) 3 (0.6%) 693 (18.3%) 99 (20.8%) 41

c (%) (%) 1. 1,183 (16.4%) 93 (15.4%) 2. 3,148 (43.5%) 378 (62.8%) 2,904 (40.1%) 131 (21.8%) 7,235 (100.0%) 602 (100.0%) 3,148 378 (%) (%) 1. 1,704 (54.1%) 136 (36.0%) 2. 738 (23.4%) 88 (23.3%) 3. 441 (14.0%) 25 (6.6%) 4. 142 (4.5%) 14 (3.7%) 5. 496 (15.8%) 72 (19.0%) 6. 48 (1.5%) 148 (39.2%) 7. 1,114 (35.4%) 100 (26.5%) 8. 237 (7.5%) 25 (6.6%) 9. 68 (2.2%) 19 (5.0%) a. 33 (1.0%) 5 (1.3%) b. 22 (0.7%) 0 c. 40 (1.3%) 9 (2.4%) 605 (19.2%) 87 (23.0%) (%) (%) 1. 217 (6.9%) 19 (5.0%) 2. 80 (2.5%) 16 (4.2%) 3. 58 (1.8%) 3 (0.8%) 4. 19 (0.6%) 5 (1.3%) 5. 47 (1.5%) 9 (2.4%) 6. 3 (0.1%) 12 (3.2%) 7. 110 (3.5%) 23 (6.1%) 8. 29 (0.9%) 2 (0.5%) 9. 6 (0.2%) 3 (0.8%) a. 9 (0.3%) 0 b. 5 (0.2%) 1 (0.3%) c. 10 (0.3%) 6 (1.6%) 605 (19.2%) 87 (23.0%) 42

c (%) (%) 1. 3 (0.1%) 3 (0.8%) 2. 1 (0.0%) 0 3. 5 (0.2%) 0 4. 5 (0.2%) 0 5. 0 0 6. 0 0 7. 0 1 (0.3%) 8. 3 (0.1%) 2 (0.5%) 9. 0 0 a. 1 (0.0%) 0 b. 3 (0.1%) 0 c. 1 (0.0%) 0 605 (19.2%) 87 (23.0%) (%) (%) 1. 15 (0.5%) 2 (0.5%) 2. 12 (0.4%) 1 (0.3%) 3. 7 (0.2%) 1 (0.3%) 4. 3 (0.1%) 0 5. 4 (0.1%) 0 6. 5 (0.2%) 3 (0.8%) 7. 24 (0.8%) 7 (1.9%) 8. 6 (0.2%) 1 (0.3%) 9. 0 0 a. 6 (0.2%) 3 (0.8%) b. 3 (0.1%) 1 (0.3%) c. 3 (0.1%) 0 605 (19.2%) 87 (23.0%) (%) (%) 1. 2 (0.1%) 1 (0.3%) 2. 2 (0.1%) 1 (0.3%) 3. 1 (0.0%) 0 4. 2 (0.1%) 2 (0.5%) 5. 2 (0.1%) 0 6. 3 (0.1%) 1 (0.3%) 7. 5 (0.2%) 2 (0.5%) 8. 0 0 9. 8 (0.3%) 1 (0.3%) a. 6 (0.2%) 2 (0.5%) b. 5 (0.2%) 0 c. 7 (0.2%) 3 (0.8%) 605 (19.2%) 87 (23.0%) 43

10 7,235 602 (%) (%) 1. 1,331 (18.4%) 138 (22.9%) 2. 723 (10.0%) 162 (26.9%) 3. 380 (5.3%) 36 (6.0%) 4. 367 (5.1%) 103 (17.1%) 5. 452 (6.2%) 184 (30.6%) 6. 1,287 (17.8%) 145 (24.1%) 7. 593 (8.2%) 55 (9.1%) 8. 173 (2.4%) 31 (5.2%) 9. 446 (6.2%) 68 (11.3%) 10. 234 (3.2%) 18 (3.0%) 11. 63 (0.9%) 7 (1.2%) 12. 140 (1.9%) 14 (2.3%) 13. 38 (0.5%) 8 (1.3%) 2,870 (39.7%) 56 (9.3%) 11 (%) (%) 1. 2029 41 (0.6%) 4 (0.7%) 2. 3039 205 (2.8%) 53 (8.8%) 3. 4049 662 (9.1%) 140 (23.3%) 4. 5059 1,602 (22.1%) 207 (34.4%) 5. 6069 2,282 (31.5%) 113 (18.8%) 6. 7079 2,024 (28.0%) 49 (8.1%) 7. 8089 269 (3.7%) 3 (0.5%) 8. 9099 6 (0.1%) 0 144 (2.0%) 33 (5.5%) 7,235 (100.0%) 602 (100.0%) 12 (%) (%) 1. 3,440 (47.5%) 91 (15.1%) 2. 3,739 (51.7%) 481 (79.9%) 56 (0.8%) 30 (5.0%) 7,235 (100.0%) 602 (100.0%) 44

13 13-1 (%) (%) 1. 360 (5.0%) 69 (11.5%) 2. 5,808 (80.3%) 444 (73.8%) 3. / 952 (13.2%) 59 (9.8%) 115 (1.6%) 30 (5.0%) 7,235 (100.0%) 602 (100.0%) 13-2 7,235 602 (%) (%) 1. 594 (8.2%) 64 (10.6%) 2. () 5,607 (77.5%) 433 (71.9%) 3. 212 (2.9%) 27 (4.5%) 4. 541 (7.5%) 62 (10.3%) 5. 143 (2.0%) 23 (3.8%) 6. 323 (4.5%) 44 (7.3%) 7. 156 (2.2%) 17 (2.8%) 8. 25 (0.3%) 2 (0.3%) 9. 3,390 (46.9%) 277 (46.0%) 10. 740 (10.2%) 23 (3.8%) 11. 877 (12.1%) 23 (3.8%) 12. 37 (0.5%) 4 (0.7%) 13. 20 (0.3%) 4 (0.7%) 105 (1.5%) 33 (5.5%) 13-3 (%) (%) 1. 118 (1.6%) 20 (3.3%) 2. 354 (4.9%) 63 (10.5%) 3. 198 (2.7%) 30 (5.0%) 4. 355 (4.9%) 46 (7.6%) 5. 4,792 (66.2%) 231 (38.4%) 6. 248 (3.4%) 20 (3.3%) 7. 30 (0.4%) 3 (0.5%) 1,140 (15.8%) 189 (31.4%) 7,235 (100.0%) 602 (100.0%) 45

14 14-1 (%) (%) 1. 372 (5.1%) 18 (3.0%) 2. 345 (4.8%) 27 (4.5%) 3. 262 (3.6%) 35 (5.8%) 4. 276 (3.8%) 15 (2.5%) 5. 1,223 (16.9%) 112 (18.6%) 6. 318 (4.4%) 54 (9.0%) 7. 717 (9.9%) 81 (13.5%) 8. 35 (0.5%) 5 (0.8%) 9. 1,006 (13.9%) 129 (21.4%) 10. 13 (0.2%) 1 (0.2%) 11. 1,140 (15.8%) 31 (5.1%) 12. 114 (1.6%) 26 (4.3%) 1,414 (19.5%) 68 (11.3%) 7,235 (100.0%) 602 (100.0%) (%) (%) 1. 272 (3.8%) 19 (3.2%) 2. 281 (3.9%) 25 (4.2%) 3. 211 (2.9%) 27 (4.5%) 4. 190 (2.6%) 12 (2.0%) 5. 694 (9.6%) 55 (9.1%) 6. 213 (2.9%) 38 (6.3%) 7. 447 (6.2%) 85 (14.1%) 8. 27 (0.4%) 2 (0.3%) 9. 1,274 (17.6%) 161 (26.7%) 10. 3 (0.0%) 2 (0.3%) 11. 2,079 (28.7%) 79 (13.1%) 12. 96 (1.3%) 26 (4.3%) 1,448 (20.0%) 71 (11.8%) 7,235 (100.0%) 602 (100.0%) 46

14-2 (%) (%) 1. 210 (2.9%) 6 (1.0%) 2. 180 (2.5%) 6 (1.0%) 3. 555 (7.7%) 17 (2.8%) 4. 338 (4.7%) 23 (3.8%) 5. 567 (7.8%) 43 (7.1%) 6. 567 (7.8%) 109 (18.1%) 7. 452 (6.2%) 23 (3.8%) 8. 389 (5.4%) 94 (15.6%) 9. 232 (3.2%) 42 (7.0%) 3,745 (51.8%) 239 (39.7%) 7,235 (100.0%) 602 (100.0%) (%) (%) 1. 165 (2.3%) 6 (1.0%) 2. 112 (1.5%) 4 (0.7%) 3. 314 (4.3%) 5 (0.8%) 4. 200 (2.8%) 22 (3.7%) 5. 380 (5.3%) 28 (4.7%) 6. 384 (5.3%) 84 (14.0%) 7. 282 (3.9%) 14 (2.3%) 8. 311 (4.3%) 71 (11.8%) 9. 180 (2.5%) 44 (7.3%) 4,907 (67.8%) 324 (53.8%) 7,235 (100.0%) 602 (100.0%) 14-3 (%) (%) 1. 1,134 (47.5%) 115 (48.1%) 2. 219 (9.2%) 10 (4.2%) 3. 719 (30.1%) 80 (33.5%) 4. 94 (3.9%) 17 (7.1%) 5. 220 (9.2%) 17 (7.1%) 2,386 239 (%) (%) 1. 638 (67.7%) 56 (71.8%) 2. 73 (7.7%) 6 (7.7%) 3. 53 (5.6%) 5 (6.4%) 4. 127 (13.5%) 8 (10.3%) 5. 41 (4.3%) 0 6. 11 (1.2%) 3 (3.8%) 943 78 47

15 (%) (%) 1. 120 423 (5.8%) 25 (4.2%) 2. 120300 1,663 (23.0%) 80 (13.3%) 3. 300400 1,228 (17.0%) 72 (12.0%) 4. 400500 753 (10.4%) 47 (7.8%) 5. 500600 559 (7.7%) 53 (8.8%) 6. 600800 709 (9.8%) 101 (16.8%) 7. 8001,000 499 (6.9%) 87 (14.5%) 8. 1,0002,000 469 (6.5%) 80 (13.3%) 9. 2,000 73 (1.0%) 16 (2.7%) 859 (11.9%) 41 (6.8%) 7,235 (100.0%) 602 (100.0%) 16 A. (%) (%) 1. 50 3,361 (46.5%) 327 (54.3%) 2. 50100 840 (11.6%) 52 (8.6%) 3. 100150 302 (4.2%) 16 (2.7%) 4. 150200 119 (1.6%) 12 (2.0%) 5. 200250 50 (0.7%) 2 (0.3%) 6. 250300 34 (0.5%) 2 (0.3%) 7. 300350 24 (0.3%) 2 (0.3%) 8. 350400 4 (0.1%) 0 9. 400450 4 (0.1%) 0 10. 450500 2 (0.0%) 0 11. 500550 2 (0.0%) 1 (0.2%) 12. 550600 2 (0.0%) 0 13. 600650 3 (0.0%) 1 (0.2%) 14. 650700 1 (0.0%) 0 15. 700750 2 (0.0%) 0 17. 800850 2 (0.0%) 0 18. 850900 1 (0.0%) 0 23. 1,0001,150 1 (0.0%) 0 30. 1,4501,500 1 (0.0%) 0 2,480 (34.3%) 187 (31.1%) 7,235 (100.0%) 602 (100.0%) 48

16 D (%) (%) 1 50 1,023 (14.1%) 150 (24.9%) 2 50100 154 (2.1%) 23 (3.8%) 3 100150 71 (1.0%) 10 (1.7%) 4 150200 31 (0.4%) 3 (0.5%) 5 200250 21 (0.3%) 1 (0.2%) 6 250300 2 (0.0%) 1 (0.2%) 7 300350 9 (0.1%) 2 (0.3%) 8 350400 4 (0.1%) 0 9 400450 0 2 (0.3%) 12550600 1 (0.0%) 0 16750800 1 (0.0%) 0 5,918 (81.8%) 410 (68.1%) 7,235 (100.0%) 602 (100.0%) 49

5 7885 48 20 17 6 25 4 50

GVHD 51

20 52

2003 53

I 1. 2. 4 11. 54

1. 2. 3. 4. 5. 5. 55

II 1. 2. 3. 4. 5. 6. 7. 8. 56

a. b. c. a. b. d. 2003, 57

III 1. 2. 1. 2. 3. 1. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 4. 5. 6. 58

1. 2. 3. 4. 5. 1. 2. 3. 4. 5. 6. 59

A 1 B(1)+(2)+(3) C AB D EC+D 60

7.885 2004 6 411-8777 1007 TEL 0559895222 FAX 0559895783 3 5