2012 29 4 Meta 1 2 2 1. 91 440003 2. 310012 6 1. P < 0. 01 P < 0. 01 P < 0. 012. P < 0. 0195% OR = 0. 860. 55-1. 17 P > 0. 05 Meta R971. 43 A 2095-3593201204 - 0288-05 Meta-analysis of Clinical Effects of Ziprasidone in the Treatment of Mania Wang Jia-wei 1 Ren Zhi-bin 2 Jin Wei-dong 2 1. PLA Mental Disease Prevention And Therapy Institute Henan Jiaozuo 440003 2. Tongde Hospital Affiliated to Zhejiang Prevince TCM UniversityZhejiang Province Mental Health Center Zhejiang Province Tongde Hospital Zhejiang Hangzhou 310012 AbstractObjectiveTo assess the difference in ziprasidone treatment of mania controlled in clinical. Methods6 studies meeting our criteria were analyzed by based-evidence medicinecomparing their difference in efficacy. Results1. Comparing to the blank group ziprasidone group had higher changing on symptomseffective rate P < 0. 01. 2. Comparing to the positive drugs ziprasidone group had lower changing on of symptomsp < 0. 01. The OR was 0. 860. 55-1. 17. ConclusionZiprasidone is a better drugs in the treatment of patients with mania its effects similar to the other positive drugs. Key WordsZiprasidoneManiaMeta-analysis 21 2 I 40 ~ 80 mg /d 65 2003 Keck 137 3 1 210 DSM-IV I 2 1 Meta 40 ~ 80 mg bid 1 1. 1 1 Potkin2005 2 4 3 4 5 6 2012 6 1. 2 E-mailwangjiawei137@ sina. com E-mailwdjin @ 163. com 288 1
2012 Vol. 29No. 4 Drug Evaluation Research RCT 2 3 4 5 YMRS FMRS 6Jaddad 2 7 8 1. 3 2 2-6 1 1. 5 2 Q 3 4 Peto / Meta 5 6 Meta 8 OR 9 OR 95% revmam4. 2 1. 4 1 2 2. 1 1 1 3 2 3 5-2A 5-HT2A 2 2. 2 4 5 6 D2 289
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2012 Vol. 29No. 4 Drug Evaluation Research 5 6 P < 0. 01 P < 0. 01 H1 P < 0. 01 9 P < 0. 01 95% OR = 0. 860. 55 ~ 1. 17 11 P > 0. 05 Meta Dubovsky SL2011 584 7 8 10 1Keck PE JrVersiani MPotkin Set al. Ziprasidone in Mania Study Group. Ziprasidone in the treatment of acute bipolar maniaa three-week placebo-controlleddouble-blindrandomized trial. Am J Psychiatry 20031604 741-748. 2Potkin SGKeck PE JrSegal S J Clin Psychopharmacol2005 Aug254 301-310. 3. J. 2010 4. J. 2010 2610 1806-1807. et al. Ziprasidone in acute bipolar mania a 21-day randomizeddouble-blindplacebo-controlled replication trialj. 2220 2577-2579. 291
2012 29 4 8Berger AEdelsberg JSanders KNet al. Medication adherence and utilization in patients with schizophrenia or bipolar disorder receiving aripiprazolequetiapineor ziprasidone at hospital dischargea retrospective co- 5. hort studyj. BMC Psychiatry2012121 99. J. 2012 125 668-669. 9Simpson GMGlick IDWeiden PJet al. Randomizedcontrolleddouble 6. - blind multicenter comparison of the efficacy and tolerability of ziprasidone J. 2011 6 31 39-40. and olanzapine in acutely ill. inpatients with schizophrenia or schizoaffective 7Dubovsky SLDubovsky AN. Ziprasidone for maintenance treatment of bipo- disorderj. Am J Psychiatry200416110 1837. lar I disorder in adultsj. Expert Opin Pharmacother2011 125 817-24. 10. Meta J. 2011 142C 596-597. 11. Meta J. 2008215 350-352. TGA TGA γ- GABA 2000 Stilnox TGA parasomnias 2007 4 TGA 2001 ~ 2008 2007 * 54 29 36 28 201 27 536 12 96 7 190 7 40 6 * TGA / TGA 292