Implementation of Bluetooth-Based Biomedical Signal Monitoring System Student : Ta-Chang Lee Advisor : Dr. Ting-Chao Hou A Thesis Submitted to Institu

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1 Implementation of Bluetooth-Based Biomedical Signal Monitoring System

2 Implementation of Bluetooth-Based Biomedical Signal Monitoring System Student : Ta-Chang Lee Advisor : Dr. Ting-Chao Hou A Thesis Submitted to Institute of Communication Engineering College of Engineering National Chung Cheng University in Partial Fulfillment of the Requirements for the Degree of Master in Communication Engineering January 2005 Chiayi, Taiwan, Republic of China

3 (MCU)

4 Abstract This thesis proposes using Bluetooth devices to realize a biomedical signal monitoring system. In this system, we use the micro controller (MCU) as the front-end device to design several circuits to capture signals of ECG, body temperature, and blood pressure, and then send these data through Bluetooth module to the monitoring device in real-time. The monitoring devices further communicates with the back-end server or PDA through wireless LAN, either to relay the biomedical signal to a PDA or to retrieve patient related information from the server. We test and verify functions of each modules of the monitoring system. The results show our proposed wireless biomedical signal monitoring system is very feasible for future wireless home tele-care application. Keywords: Micro Controller, Biomedical signal monitoring, ECG, Bluetooth, Home tele-care

5

6 LCD (Liquid Crystal Displayer) EM78P153SEM78P458A EM78Pxxx E WICE (Bluetooth Dangle) (ECC )...27 i

7 LCD Visual Basic ii

8 LCD LCD EM78P153S EM78P458A WICE WICE WICE RS USB ECG iii

9 UART DB Null Modem ASCII Code ECG LCD LCD LCD LCD BPn LCD LCD LCD PDA LCD...48 iv

10 1 1.1 (ECG) BluetoothTM PDA (ECG) 1.2 PDA 1

11 a1 a2 a3 a4 0 Vcc1 MCU GND 0 b1 b2 b3 b PDA EM78Pxxx EM78P458AEM78P153S 1-1 Wireless LAN Bluetooth PDA House 8 Bluetooth Dangle Bluetooth Access Point Wireless LAN Wireless LAN Hospital Client Bluetooth Dangle & Wireless Card Wireless Card Clinic Server Internet Router Indoor Outdoor 1-1 2

12 1.3 2 (ECG) 3 4 (ECG) LCD 5 Visual Basic embedded Visual Basic (Client) (Server) 6 3

13 2 (LCD) LCD LCD LCD

14 (Hz) 25 ~ 400 mmhg DC ~ 50 Pressure gage 0.5 ~ 4 mv 0.01 ~ 250 Skin electrodes 3 ~ 300 uv DC ~ 150 Scalp electrodes 10 ~ 1000 uv DC ~ 1 Skin surface electrodes 0.1 ~ 5 mv DC ~ Needle electrodes 500 ~ 3500 uv DC ~ 50 Contact electrodes (SA node)

15 (polarized) (depolarized) P (AV node) 1/ PQ 1/ Q 2-1 R 2-1 T QRS T P QRS 2-3 6

16 (ElectrocardiogramECG) (0.05~100Hz) 1~10mV ECG

17 (Centigrade) (Fahrenheit) (Kelvin) 2-6 (beads) (discs) (washers) (rods) (glass probes) 8

18 (1) 120~80mmHg(2) 60~90mmHg 0~10mmHg Stephen Hales 9

19 Poiseuille mmhg 19 Riva-Rocci Barnard (cuff) (Sphygmomanometer) 1905 N.S. Korotko Direct measurement method invasive method Indirect measurement method noninvasive method non-invasive Sphygmomanometer Auscultation Sphygmomanometer 10

20 Systolic Pressure Diastolic Pressure (MAP) (SBP) (DBP) ( 2-8 ) 11

21 LCD (Liquid Crystal Displayer) LCD 2-9 LCD AB

22 2-10 LCD (A) OFF (B) ON 2-10 LCD 60Hz 60Hz V V on 2-11(A) 8 LCD (Segment) 1:21:31:4 S n off Sn S n

23 LCD BP0BP S n BPn V on = state1 Sn BP0( t ) on( rms) () t = V () t V state2 Sn BP1( t) off ( rms) 1:4 V VOP 4K + 1 VOP K + 1 V 2 off = 2 (2n + 1) (2n + 1) K 8 n 1 : 4 S n 1 V VOP 33 = = 0.638V 9 V () t = V () t V V VOP = = 0.333V 3 OP n OP LCD V 0.638V 0.333V 0.333V 0.638V OP OP OP OP OP 14

24 LCD 1 : 2 1 : 3 1 : 4 (A) LCD (B) LCD 2-11 LCD LCD 4 LCD V 1:4 LCD 0 ~ (A) ab cdefg on 15

25 3 3-1 (MCU) UART (Bluetooth Dangle) ASCII Code (3-1 Client ) (3-1 Server ) b (Wireless Card) Sensors Micro Controller GND Bluetooth Dangle Bluetooth Dangle Wireless Card Database Server Wireless Card Client Server Wired Wireless

26 (MCU) Visual Basic 3.1 EM78Pxxx (Microcontroller UnitMCU) 8 RISC WICEWriter MCU EM78Pxxx 7 EM78P153EM78P156EM78P257EM78P447EM78P451EM78P458/9 EM78P468 (ROM RAM)I/O (INT) Pin EM78P153 I/O Pin RAM/ROM I/O EM78P458/9 EM78P153 EM78P458 DIP( ) 17

27 Voltage ROM RAM I/O INT Timer WDT PIN LCD IRC Frequency Pins EM78P V~5.5V 1K 32 11I/O 3(1/2) 1 Yes DC~20MHz &1I EM78P ~5.5 1K (1/2) 1 Yes 18/ DC~36MHz EM78P ~5.5 DC~20MHz EM78P ~5.5 2K 80 16/18 5(1/4) 3/4 Yes 18/20 - IRMouse 4K /24 2(1/1) 1 Yes 28/ PWM DC~20MHz EM78P ~5.5 4K (1/3) 2 Yes 40,44 - SPI EM78P458 EM78P459 EM78P468 DC~20MHz 2.3~5.5 DC~16MHz 2.2V~5.5V DC~16MHz 4K (1/5) 3 Yes 20/24 - A/DPWM 4K /28 9(3/6) 5 Yes 64 4*32 IRPWM EM78P153SEM78P458A EM78P153SEM78P458A MCU (1) (MCU) 8 Harvard (2) 24MHz KHz (3) Assemble C (4) RISC (5) RAM 1K bytes ROM (6) (7) (8) ( 01 ) 18

28 (9) (writer) OTP MCU 3-2 EM78P153S 3-3 EM78P458A 3-2 EM78P153S 3-3 EM78P458A EM78Pxxx E8 E8 EM78Pxxx MCU RAMROMI/O 3-4 Printer Cable E8 E8 MCU 19

29 WICE WICE Win98Win2000WinXP 8 Windows ICE WICE (1) Special Purpose Register General Purpose Register 3-5 WICE 20

30 (2) maplist : 0 error 3-6 WICE (3) E8 (4) Register Register 3-7 WICE EM78Pxxx 4 EM78Pxxx 21

31 3.2 (Bluetooth Dangle) (Bluetooth) 2.4 GHz ISM ( ) l Mbytes/sec ISM ISM 79 1MHz 1600 GFSK (Gaussion Frequency Shift Keying) 721 Kbps GHzISM 5.8GHz ISM 1 MHz Circuit Switch Packet Switch 1600 /(625us/slot) 10 (Class 2lmW) /100 (Classl100mW) Kbits/sec ( ) USBUART (RS-232)

32 (Piconet) Master S1ave 7 (Active) Slave 256 (PARK) Slave Master Slave Master DB9 RS232 I/O RS232 ASCII Code 3-8 RS232 (1) RS-232 cable (2) v1.1 (3) (4) Com Port (5) (Baud Rate) 4800 bps ~ bps (6) < 10m (7) Bluetooth Profiles Generic Access ProfileSerial Port Profile (8) Bluetooth Radio class 2 23

33 (9) RS-232 DB9-F (10) +5V DC/500mA 80mA USB 3-9 RS232 USB RS-232 USB Com Port 3-9 USB (1) Windows98SEMENT2000XP USB (2) (3)Bluetooth Radio class 2 (4) Data Rate720 Kbps (5) < 10m (6) v1.1 PC NOTEBOOK PDA 1600 / (Master-S1ave) Pin l mw 24

34 (FCC) b Wireless CardWireless HubPDA (Client) (Server) PDA TCP/IP PDA IP IP 25

35 4 (MCU) 4-1 EM78Pxxx EM78P153SEM78P458A LCD LCD TCP/IP

36 4-2 Biomedical Signals ECG, Body temperature, Blood pressure, Bluetooth dangle 4-2 (1) (2) (3) (4) (5) DanglePCPDA 4.1 (ECC ) ECG ECG 60Hz 4-3 RALLRL 5 ~ 10 1 ~ 5 Analog Device AD Hz 100Hz 27

37 150 ~ Hz SNR OP177 layout 4-3 ECG (1) 28

38 Analog Device IC AD620 RG 0 ~ 7 (2) Butterworth a.) 0.5Hz 3dB 0.5Hz 4-4 R 4 vin C1 C2 G vout R vo () s GS H() s = = v () s 1 G i 2 S + S + ( + )/ R4 R4C1 C1 C + 2 R3R4CC 1 2 R4 R 3 R R 4 = = C + C + C2 C + C ωω d d 4 (1 G 2( 1 2) 0 n RCC 4 1 2( ωω 0 n) ) 29

39 f c 1 = 2π R RCC b) Butterworth (transition band ) 2 Butterworth Hz 2V 0.2V (3) Butterworth a) 30

40 40Hz 100Hz 3dB 100Hz C 4 vin R1 R2 G vout C G( ) vo () s RR 1 2C3C4 H() s = = vi () s 1 G R + R S S R 2 C 3 RR 1 2 C 4 RR 1 2 C 3 C 4 R1 R 2 R 1 = 2 d + d C3 C4 + G 4( / 1 ) 2 ωω ( C + (1 G) C ) 0 n 3 4 R 1 = 2 2 RCC 1 3 4( ωω 0 n) C3 C4 C3 C4 d 2 /4 1+ G f c 1 = 2π R RCC b) 31

41 Butterworth (transition band ) 2 Butterworth Hz 2V 0.2V 4-8 (4) 8 bits Analog to Digital

42 A/D converter ADC0804 ADC bits A/D converter DB0~DB7 ADC bits I/O Port APort B (5) A/D

43 AD620-12V~+12V 1 1 OP177-12V~+12V 2 1 OP177-12V~+12V 34 2 OP177-12V~+12V 56 2 LM399 0V~+12V 7 1 OP177 0V~+5V 89 2 ADC0804 0V~+5V A/D Converter 10 1 EM78P458 0V~+5V 11 1 MAX233 0V~+5V IC RS (6)

44 Rm Rc ( ) C 4-13(A)(B) R Tm RmC Rm T RC = Tc RcC Rc p MCU (A) (B)

45 GND A/D ENB RA0 inputra1 inputra2 output 0 C RA2 0 RA0 output 1 RA1 inputra2 input IC Rc C RA2 C IC ( 1 V )RA cc RA0 C RA2 Tc C RA0 inputra1 output 1 RA2 inputic Rm C RA2 C RA2 0 1 Tm C 4.3 Sensor Filter Amplifier One-Channel One-Channel GND Battery Data Bus /INT0 ADC Data Bus INT0 V B 1 V ref B 8 Bluetooth Dangle TxD RxD ADC Enable /EN Micro-Controller P1.0 Key Pad S0-S4 Power/Stop KB0-KB4 P1.0 P

46 4-14 (filter) 4-12 EM78P458A A/D ConverterADC0804 AD0 EM78P ADC Hz ADC0804 EM78P458 ADC0804 A/D No? Yes EM78P458 Port A AD

47 A/D A/D I/O delay debug 8 bits Port A 4.4 (Universal Asynchronous Receiver Transmitter UART) 8 UART UART 38

48 Idle mode Start bit bit0 bit1 bit2 bit3 bit4 bit5 bit6 bit7 Stop bit Idle mode 4-17 UART UART 0 +3V ~ +15V l -3V ~ -15V bits 1 (Baud Rate) UART bps EM78Pxxx Vcc = +5V Vss = 0V UART I/O 5V 0V UART 0 1 UART I/O Analog Device IC ADM232 IC Tx Tin 0V Tout +12V Tin 5V Tout -12V Rx Rin +12V Rout V 39

49 Rin -12V Rout +5V ADM uF ADM232 Vcc = +5VVss = 0V 爲 DB9 DB9 Com Port DB9 Null Modem 4-19 Tx Rx UART Null Modem 40

50 Connector 1 Connector 2 Function 2 3 Rx Tx 3 2 Tx Rx 5 5 Signal ground MHz Crystal 4MHz 4 clock 1/( ) = 1us us bit 9600 bps 1/(4MHz/4)= 1us Baud Rate IC Baud Rate Baud Rate MAX clock 4 MHz Crystal 4 clock 4800 bps 9600 bps bps bps : 9600,N,8, UART ASCII Code ETB 0 ~ ~ 9 ASCII Code 16 ASCII Code UART 10 bits 41

51 4-21 ASCII Code 4.1 ~

52 Com Port 4-23 windows ECG 8 爲 ECG E 3 ECG T 3 爲 Visual Basic Visual Basic E 3 ECG T Hz ECG 4-23 ECG 43

53 4.6 LCD LCD 4-24 LCD EM78P458A LCD LCD 2 LCD LCD BPn S n 44

54 BPn 4-26 LCD BPn S n S n BPn S n 4-26 LCD S BPn LCD ms 8 BP0 BP1 n 45

55 BP0 BP0 0 BP1 BP LCD 10 BP0 BP1 BP0 + BP1 10 LCD BP0BP1 8 LCD 4-28 爲 BP0BP1 5 Gate1Gate2Gate3Gate4Gate5 5 46

56 LCD BPn 爲 TOSHIBA AC to AC ICTC Gate EM78P458A A/D Converter EM78P458 EM78P153 EM78P458A UART ASCII Code

57 4-29 LCD EM78P458A 0V ~ +5V 1 EM78P153S 0V ~ +5V UART 1 TC4066 0V ~ +5V 4 ADC0804 0V ~ +5V 1 ADM232 0V ~ +5V UART LCD

58 0~9 UART TC4066 ADC0804 EM78P458A EM78P153S 4-30 LCD LCD (1) (2) (3) LCD (4) Gate1Gate2Gate3Gate4Gate5 Gate A/D converter BP0BP1 (5) EM78P458A

59 (6) EM78P153S EM78P458A RS232 (7) LCD 4-32 Yes No Gate2 34 LCD Gate2 Yes No Yes No Gate3 56 IC Counter > 1.2 Gate3 Yes Yes No Gate4 78 LCD Gate Yes No Gate5 90 No Gate1 12 Gate1 Yes Gate5 Yes 4-32 LCD 50

60 (8) LCD 爲 Visual Basic LCD 5 ECG LCD UART (ASCII Code) Visual Basic 51

61 PC Notebook Pocket PC Microsoft Visual Basic v6.0 Visual Basic Visual Basic I/O ( ) Pentium4 PC (CPUl.6GHZ256MBytes RAM) Visual Basic v6.0 Pocket PC Pocket PC Pocket PC (Pocket PC 2003) Microsoft ( embedded Tools 3.0 evc++evb ) (SDCFSM ) I/O ( GSMGPRS ) 52

62 Pocket PC (400MHz) (2.3GHz) (Pocket PC) (HP) ipaq H5500 (Personal Digital Assistant) 1. Pocket PC MHz Intel XScale (128 Mbytes RAM 48 Mbytes Flash ROM) 3.TFT ( * mm*84mm*15.9mm206.8g b 6.SD/MMC Pocket PC PC embedded Visual Basic 5.2 Visual Basic Visual Basic HCI ACL (Thread) Visual Basic ECG Visual Basic 53

63 (Com Port) 5-2 (Wireless Card) (Wireless Hub) TCP/IP START Open Winsock Open COM Port Interrupt Service Routine Setting Winsock Send START Signal To MCU Read Data from MCU Listen Decomposition Data Wait Connection Request Main Program No Paint Accept Wait User STOP Yes Check Monitoring Flag Setup Connection Send STOP signal To MCU Send_Flag Send Data via TCP/IP Stop_Flag Wait Command No Return Close Com Port Return from ISR END Yes Check Command Command START Set Send_Flag Set Stop_Flag Close Winsock Command STOP

64 START Open Winsock Interrupt Service Routine Setting Winsock Read Date Connect Decomposition Data Time Out Interrupt Occur Paint No Connected Return from ISR Yes Connected Main Program Command START Start User Command Close Winsock END Stop Command STOP Send STOP signal 5-2 Visual Basic 55

65 ECG ECG LCD Visual Basic 56

66 Visual Basic (Client) 2 (Wireless Card) (Client) (Server) (Wireless Hub) IP address Visual Basic Winsock TCP/IP Visual Basic 5-5 Web Camera Client Server Wireless Card Wireless Card Bluetooth Wireless LAN 5-5 PDA

67 PDA 5-6 PDA ECG ECG PDA ECG 5-6 PDA (Web Camera) ECG Visual Basic (Motion JPEG) (Motion JPEG) Visual Basic

68 START Open Video Window Start Motion JPEG Close Video window No Setting Video Window Wait RTS END Listen Yes No Wait Connection_Request Signal Yes Send Image Packet Receive ACK No Yes Yes Accept Send Over Yes Setup Connection Send Complete Signal No Wait START signal No Check STOP 5-7 (START) (JPEG Packet) (STOP) 59

69 TCP/IP 5-9 Winsock TCP/IP (START) (JPEG Packet) RTS (STOP) 60

70 START Open Winsock Send Start signal Setting Winsock Send RTS Connect Receive Image Packet No No Time_Out Send ACK No Connected Receive Complete Yes Check User Command STOP DisConnect No User Stop START Yes Command Start Close Winsock Yes END

71

72 6 6.1 QRS ( ) GSM MMS GPS RFID 63

73 ( ) 2. AA 1600mAh 5V500mA IC sleep mode wake up CR-V3 AA 3. Pocket PC Smart phone ( Symbian OSWindows Mobile S) API 4. ( ) 64

74 5. (V1V6) 6. GPS GSM 7. A/D Embedded 65

75 [1] "Visual Basic RS-232 " [2] "Pocket PC RS-232 [3] Visual Basic 6.0 [4] "Pocket PC [5] [6] [7]"Bluetooth Technology [8] [9] [10] EM78P458/EM78P459 [11] [12] Bluetooth, Specification of the Bluetooth System Core, December [13] Bluetooth, Specification of the Bluetooth System Profiles, December [14] R. Balochi, et al., Development of an electronic medical record for patient care in Cardiology, September

76 [15]IAR MakeApp for the Bluetooth Protocol Stack Embedded Edition v1.30a USER GUIDE. [16] J. J. Carr, J. M. Brown, Introduction to Biomedical Equipment Technology Fourth Edition [17] K. W. Jung, J -S. Chung, "Bluetooth Telecommunication Experiments", Vision Publishing Company, [18] A. Benassi, et al., "Use of an electronic medical record in a department of Cardiology"Computers in Cardiology 2000, [19] J. G. Webster, "Medical Instrumentation Application and Design", Third Edition. 67

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