* 於開曼群島註冊成立的有限公司 股份代號 1548 * 2015 年度報告 * 僅供識別
(i)(ii) (iii) (iv)
2 3 5 6 7 10 20 26 43 57 59 60 61 63 65 67 1
(i)(ii) (iii) (iv) 76.92.56.01.388.7% 2.9% 6.9%1.5% 57.2% 25.0% 12.9% 1.5% 3.4% 100 43.617.012.36.63.7 50.3% 19.6% 14.2% 7.6% 4.3% 2
James Zuie Huang Eric Wang 15 33 1 22 189 22 Clifton House 75 Fort Street P.O.Box 1350 Grand Cayman KY1-1108 Cayman Islands 28 3
28 18 Appleby Trust (Cayman) Ltd. Clifton House 75 Fort Street P.O.Box 1350 Grand Cayman KY1-1108 Cayman Islands www.genscript.com www.bestzyme.com 1548 183 17 1712 1716 51 2 20 Scotch Plains 336 Park Avenue Scotch Plains NJ 07076 USA 88 4
70.0 23.9%86.7 44.1 29.5%57.1 6.2 182.3%17.5 6.2130.6%14.3 6.2 182.3%17.5 6.2 130.6%14.3 5
四年財務概要 52,990 60,104 69,994 86,709 35,443 38,258 44,098 57,078 9,182 6,000 6,175 17,504 9,182 6,000 6,175 17,504 0.0078 0.0051 0.0052 0.0147 0.0076 0.0050 0.0051 0.0143 45,490 45,274 48,588 49,060 30,099 38,561 43,792 133,014 30,252 29,885 29,188 30,894 (153) 8,676 14,604 102,120 1,181 1,387 1,445 1,932 44,156 52,563 61,747 149,248 18,660 22,457 25,637 103,720 20 22 22 26 44 56 59 65 27 30 33 33 6
DNA (i)(ii) (iii) (iv) 100 13 14,500 7
86.7 23.9%(i) (ii) (iii) 29.5%57.14.6% 65.9% 17.5 14.3130.6% 7.18.2% 199 CRISPERCRISPR grna ERPSAP 63.3%7.6% 8
45 594,950 14% 160 30% 20331 18 9
(i)(ii) (iii)(iv) GenScript (i) Geneplus (ii) 86.770.0 23.9%57.144.1 29.5% (i) (ii) 17.56.2 182.3% 6.2130.6%14.3 10
17.56.2 182.3% 14.3 6.2 130.6% (i)(ii) (iii)(iv) 76.92.56.01.3 88.7% 2.9% 6.9% 1.5% 1. DNA 76.9 63.2 21.7%51.539.9 29.1%(i) (ii) (iii) (a) (b) (c) (d) 11
2. PCR 2.5 2.0 25.0%1.61.4 14.3%(i) (ii) (a) ; (b) 3. 6.0 4.4 36.4%3.92.8 39.3%(i)(ii) (iii) (iv) 12
4. 1.30.4 225.0%0.1 (i)(ii)(iii) 13
(%) 86,709 69,994 23.9% 57,078 44,098 29.5% 17,504 6,175 182.3% 25,934 9,252 180.3% 17,504 6,175 182.3% 25,934 9,252 180.3% 0.0147 0.0052 182.7% 0.0143 0.0051 180.4% 86.770.0 23.9% (i) (ii) 44.1 57.129.5% 15.517.613.5% (i) (ii) (iii) 21.428.533.2 %5.31.5 14
5.67.126.8% 1.75.5 21.2% 23.8%3.3 17.56.2 182.3% 5.3 130.6% 65 59 26 22 37.737.5 0.2 15
0.9 0.3 0.6 SAP 103.7 25.6 19.6 4.1(i) 7.4(ii)4.1(iii)6.8 (iv) 0.6 65.258.5 0.76.7 16
45 594,950 14%1601330% 17
2033118 12 1,300 39.845.9% 18
(%) 725 55.0% 187 14.2% 189 14.3% 137 10.4% 81 6.1% 1,319 100.0% 19
51 47 47 46 JamesZuie Huang 50 58 52 39 42 51 Genscript Corporation GS CorpGenScript Japan Inc. GSGS Bestzyme Biotech Corporation Bestzyme Biotech Limited BVI Bestzyme Biotech USA Incorporated Legend Biotech Corporation Legend Biotech Limited BVI Genscript Biotech Limited GS BVI GenScript (Hong Kong) Limited GS Genscript International Limited GS GenScript USA Incorporated GS 20
20 Schering-Plough Schering-Plough (farnesyl transferase inhibitor) Schering-PloughG Schering-Plough (Presidential Award) 155 (Duke University) 47 BVIBVI GS BVI GSGSGS GS Corp GS Corp (Bridgeport University) 21
47 25 Schering-Plough China Saint-Gobain Grains and Powder Division Quay Magnesium 46 GS CorpGS Corp GS GS 24 (Rutgers University) Schering-Plough Research Institute (Rutgers University) James Zuie Huang50 20KPCB China KPCB China Vivo Ventures Anesiva Tularik Inc.GlaxoSmithKline LLC Bristol Meyers Squibb ALZA Corp (Stanford Graduate School of Business) CASI Pharmaceuticals, IncCASI 22
58 SZSE 000550 SHA 600500 SHA 600820 SZSE 002071 SZSE 002712 52 Sunpower Group LtdSESDAQ SPWG: 39 23
HKSE 921 SZSX 000921 HKSE 3663 42 China Lodging Group HTHT China Lodging Group Synutra International, Inc. SYUT SZSE 002186 66 62 46 40 24
66 Clontech Laboratories, Inc. Cathay Biotech, Inc 62 Schering-Plough Merck & Co.Schering-Plough 46 40 25
(i)(ii) (iii) (iv) 4 5960 18317 1712-1716 6 26
1.31400,000,000 1.3160,000,000 15% 8.8% 2.2% 24.5% 10.3% 5% 13 1,600,000,00076,188,000 25 27
6364 223 48,689,00033,604,000 James Zuie Huang James Zuie Huang 28
2025 3.13 3.13 29
302,260,940 A. 17 30
302,260,940 (US$) 1,603,239 0.01 1,603,239 5,344,130 0.026 5,344,130 68,016,194 0.062 68,016,194 34,008,093 0.103 34,008,093 27,206,480 0.103 27,206,480 1,943,320 0.077 1,943,320 1,943,320 0.077 1,943,320 1,943,320 0.103 1,943,320 3,886,640 0.103 3,886,640 1,554,656 0.077 1,554,656 1,943,320 0.077 1,943,320 971,660 0.077 971,660 1,943,320 0.103 1,943,320 10,688,259 0.003 10,688,259 1,943,320 0.077 1,943,320 213,765 0.003 213,765 213,765 0.005 213,765 1,943,320 0.077 1,943,320 54,413 0.103 54,413 163 134,896,406 134,896,406 302,260,940 302,260,940 31
26 B. 17 1. (1) (2) (3) 2. 3. 302,260,940 18.89% 160,000,000 9.64% 32
30% 4. 12 1% 5. 6. 21 1.00 33
7. 0.0030.103 (1) (2) (3) 8. 8 9 13.51(2) (a) (e)(g) 34
XV7 8XV 352 (%) 1 2 3 1,092,010,145 68.25 4 2 5 1,092,010,145 68.25 6 2 7 1,092,010,145 68.25 8 5,829,960 0.36 (1) GS Corp 40.59%GS Corp (2) GS CorpGS Corp GS CorpGS Corp 908,502,024 GS Corp 108,625,000 (3) 35
(4) GS Corp 23.24%GS Corp GS Corp (5) 3,886,640 (6) GS Corp 11.76%GS Corp GS Corp (7) 136,178,136 (8) 5,829,960 18 18 XV2 3336 (%) GS Corp 1 908,502,024 56.78 KPCB 2 216,921,134 13.55 KPCB China Associates, Ltd. 2 233,198,381 14.57 3 83,000,000 5.18 FMR LLC 80,000,000 5.00 36
(1) GS Corp 40.59%23.24%23.24%11.76%1.18% (2) KPCBKPCB China Founders Fund, L.P. KPCB China Founders Fund KPCB ChinaAssociates, Ltd. KPCB China KPCB China KPCBKPCB China Founders FundKPCB ChinaKPCB 216,921,134KPCB China Founders Fund16,277,247 (3) CRC Bluesky Limited 83,000,000 XV 23 336 37
GS Corp (i) (ii) (iii) (iv) 14A 3014A 38
35,000 14 4356 25% 39
6225 33 51% 40
6 41
15% 210 42
14 43 45A.1.8A.2.1 A.1.8 43
3 33 James Zuie Huang 3.10(1) 3.10(2) 3.10A 3.13 44
James Zuie Huang A.2.1 45
46
1/1 1/1 1/1 1/1 James Zuie Huang 1/1 1/1 1/1 1/1 1/1 10 47
1. 2. 3. 4. 1. 2. 3. 4. 5. 48
A.5.6 1/1 1/1 1/1 1. 49
2. 3. 4. 5. 3 6. 7. 8. 9. 10. 11. 12. 50
1/1 1/1 1/1 8 1,000,000129,000 2 1,000,0002,000,000129,000258,000 1 2,000,0003,000,000258,000387,000 1 51
(i)(ii) (iii) 1/1 1/1 1/1 1. 2. 52
3. 4. 1/1 1/1 1/1 1/1 1/1 1/1 57 58 53
238,000 54
10 3.29 15 (www.genscript.com) 55
investorrelations@genscript.com 56
Ernst & Young 22/F, CITIC Tower 1 Tim Mei Avenue Central, Hong Kong 1 22 Tel: +852 2846 9888 Fax: +852 2868 4432 ey.com 59 124 57
58
5 86,709 69,994 (29,631) (25,896) 57,078 44,098 5 12,371 1,468 (17,642) (15,538) (28,535) (21,446) (296) (335) 7 (411) 6 22,976 7,836 10 (5,472) (1,661) 17,504 6,175 17,504 6,175 12 1.47 0.52 1.43 0.51 59
17,504 6,175 4 (9) (5,642) (266) (5,638) (275) (5,638) (275) 11,866 5,900 11,866 5,900 60
13 37,719 37,530 122 185 14 7,581 8,220 15 901 349 24 2,737 2,304 49,060 48,588 17 2,025 1,777 18 16,914 12,157 19 10,153 1,316 30 34 16 2,526 20 202 345 20 103,720 25,637 133,014 43,792 21 2,414 2,869 22 24,661 15,132 3,786 49 30 2,570 30 8,173 23 33 395 30,894 29,188 102,120 14,604 151,180 63,192 23 1,932 1,445 1,932 1,445 149,248 61,747 2015 61
25 1,600 50 27 147,648 61,664 149,248 61,714 33 149,248 61,747 62 2015
* * * * * * 252726 50 15,002 1,729 2,997 28,430 5 4,317 52,530 33 52,563 6,175 6,175 6,175 (9) (9) (9) (266) (266) (266) 6,175 (9) (266) 5,900 5,900 3,284 3,284 3,284 1,001 (1,001) 50 15,002 5,013 3,998 33,604 (4) 4,051 61,714 33 61,747 63
* * * * * * * 25252726 50 15,002 5,013 3,998 33,604 (4) 4,051 61,714 33 61,747 17,504 17,504 17,504 4 4 4 (5,642) (5,642) (5,642) 17,504 4 (5,642) 11,866 11,866 (33) (33) 595 8,602 9,197 9,197 GSGS 559 35,326 (35,885) (617) (617) (617) 400 67,208 67,608 67,608 613 (613) (3,868) (3,868) (3,868) 3,348 3,348 3,348 2,419 (2,419) 1,600 106,655 (20,883) 8,361 6,417 48,689 (1,591) 149,248 149,248 * 147,648,00061,644,000 64
22,976 7,836 6 85 39 17 347 13 75 13 4,681 4,703 15 166 76 14 170 122 6 120 26 5 (60) (86) 5 (188) (207) 7 411 3,348 3,284 31,645 16,279 (5,006) (3,164) (8,683) (23) (595) (373) 115 34 (2,570) 38 (397) (818) (455) 1,021 (1) 20 143 (144) 7,723 3,178 21,838 16,109 60 86 (2,262) (3,989) 19,636 12,206 2015 65
(4,087) (30,447) 6,810 32,400 (6,711) (7,355) 3 14 (4,012) 15 (727) (162) 616 459 (4,099) (9,114) 25 76,188 (2,842) (15,142) 7,776 8,172 (8,178) (411) 65,168 395 80,705 3,487 (2,622) (307) 20 25,637 22,457 20 103,720 25,637 103,720 22,368 3,269 20 103,720 25,637 103,720 25,637 66 2015
1. PO Box 1350, Clifton House, 75 Fort Street, Grant Cayman KY1-1108, Cayman Islands Genscript USA Corporation GS Corp % % Genscript (Hong Kong) Limited GS Genscript USA Incorporated GS 155,000 100 43,020,000 100 1 100 132,550,600 100 Genscript Japan Inc. 8,300,000 100 6,000,000 100 500,000 100 1,000,000 100 10,000,000 100 67
2.1 (a) (b) (c) (i)(ii) (iii)(i)(ii) (iii) 68
2.2 19 622 2.3 9 2 1028 10 12 1 28 11 1 14 3 15 2 1 1 1638 1 1641 1 27 1 1 1 2 3 69
2.4 70
2.4 71
2.4 72
2.4 (a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) (vi) (a) (vii) (a)(i) (viii) 73
2.4 5 2% 20% 33¹/³% 10% 20% 74
2.4 2 5 75
2.4 (a)(b) 76
2.4 (a)(b) 77
2.4 78
2.4 79
2.4 80
2.4 81
2.4 82
2.4 (a) (b) (c) (d) 26 83
2.4 20% 84
2.4 622 85
3. 2,737,0002,304,000 1,959,0001,382,000 24 86
3. 5,472,0001,661,000 1,252,0001,167,000 2,025,0001,777,000 3,348,000 3,284,000 87
4. (a) DNADNA (b) (c) (d) 76,918 5,967 2,469 1,355 86,709 51,524 3,889 1,591 74 57,078 12,371 (17,642) (28,535) (296) 22,976 88
4. 63,220 4,382 2,044 348 69,994 39,943 2,796 1,359 44,098 1,468 (15,538) (21,446) (335) (411) 7,836 (a) 43,565 34,415 17,023 14,714 12,250 8,676 6,566 5,602 3,652 3,582 3,653 3,005 86,709 69,994 89
4. (b) 45,891 45,572 432 712 46,323 46,284 10% 5. 82,885 67,602 3,824 2,392 86,709 69,994 8,500 3,106 511 1,167 188 207 60 86 6 8 12,371 1,468 90
6. 2,159 1,033 27,472 24,863 13 4,681 4,703 * 15 166 76 14 170 122 18 249 17 19 (164) 22 885 680 308 195 31,792 27,362 3,697 2,821 2,231 1,243 37,720 31,426 7,109 5,589 5,270 307 120 26 347 * 7. 411 91
8. 383(1)(a) (b) (c) (f)2 40 751 791 148 205 1,117 2,041 12 12 2,028 3,049 2,068 3,049 26 (a) 10 10 10 30 92
8. (b) * 242 6 248 401 116 1,044 1,561 108 32 73 6 219 751 148 1,117 12 2,028 10 10 10 10 231 6 237 365 199 2,021 2,585 102 6 17 6 131 698 205 2,038 12 2,953 93 3 96 * 93
9. 8 662 625 160 73 86 36 908 734 1,500,0012,000,000 1 2 2,000,0012,500,000 1 2,500,0013,000,000 2 3 3 26 94
10. 16.5%16.5% 15% 25.5% 34%9% 25% 15% 4,174 1,846 1,825 338 24 (527) (523) 5,472 1,661 22,976 7,836 25% 5,744 1,959 1,725 (48) (2,848) (1,060) (500) (413) 928 946 488 345 (65) (68) 5,472 1,661 95
11. 12. 1,192,553,0211,183,326,316 17,504 6,175 1,192,553,021 1,183,326,316 35,466,939 31,727,867 1,228,019,960 1,215,054,183 96
13. 28,347 20,578 330 2,984 1,485 53,724 (1,717) (12,759) (132) (1,586) (16,194) 26,630 7,819 198 1,398 1,485 37,530 26,630 7,819 198 1,398 1,485 37,530 130 7,391 7,521 (118) (2) (120) (683) (3,310) (30) (658) (4,681) (1,509) (357) (10) (61) (594) (2,531) 2,568 3,372 467 (6,407) 27,018 7,524 158 1,144 1,875 37,719 29,259 22,032 311 3,269 1,875 56,746 (2,241) (14,508) (153) (2,125) (19,027) 27,018 7,524 158 1,144 1,875 37,719 97
13. 28,384 17,867 331 2,777 544 49,903 (1,100) (9,329) (102) (1,101) (11,632) 27,284 8,538 229 1,676 544 38,271 27,284 8,538 229 1,676 544 38,271 67 10 24 4,115 4,216 (27) (2) (29) (623) (3,546) (31) (503) (4,703) (75) (75) (98) (23) (5) (24) (150) 2,942 208 (3,150) 26,630 7,819 198 1,398 1,485 37,530 28,347 20,578 330 2,984 1,485 53,724 (1,717) (12,759) (132) (1,586) (16,194) 26,630 7,819 198 1,398 1,485 37,530 32,753,000 6,000 98
14. 8,395 4,520 4,012 (170) (122) (479) (15) 7,746 8,395 (165) (175) 7,581 8,220 3,679,000 3,985,000 50 99
15. 349 349 696 31 727 6 (162) (4) (166) (9) (9) 874 27 901 1,339 31 1,370 (465) (4) (469) 874 27 901 264 264 162 162 6 (76) (76) (1) (1) 349 349 671 671 (322) (322) 349 349 100
16. 2,526 17. 4.205.9030 84 1,228 896 395 409 749 472 2,372 1,777 (347) 2,025 1,777 347,000 18. 17,894 12,916 129 101 18,023 13,017 (1,109) (860) 16,914 12,157 3060 101
18. 860 249 1,109 843 17 860 14,771 10,055 1,510 1,339 634 565 979 957 17,894 12,916 9,847 7,784 5,911 3,441 1,027 831 16,785 12,056 102
18. 19. 8,927 591 798 444 (i) 277 217 207 214 87 157 10,296 1,623 (143) (307) 10,153 1,316 (i) 307 (164) 143 285 22 307 103
19. 10,153 1,316 20. 103,720 25,637 202 345 103,922 25,982 (202) (345) 103,720 25,637 65,214 130 21,719 5,987 12,295 16,354 621 1,225 1,842 771 2,029 1,170 103,720 25,637 12,295,000 16,354,000 104
21. 2,414 2,869 2,340 2,813 21 10 20 19 33 27 2,414 2,869 60 22. 7,603 5,657 6,696 5,197 4,923 973 2,477 1,101 2,150 1,403 812 801 24,661 15,132 105
23. 1,840 2,207 616 459 (397) (818) (94) (8) 1,965 1,840 33 395 1,932 1,445 1,965 1,840 24. 214 10 (159) 55 234 10 (20) 214 106
24. 831 641 343 483 220 2,518 10 157 17 283 (180) 91 368 (38) (37) (3) (16) (94) 950 621 623 303 295 2,792 634 492 281 457 155 2,019 10 198 151 62 26 66 503 (1) (2) (1) (4) 831 641 343 483 220 2,518 107
24. 2,737 2,304 25,000 1,934,0001,382,000 1,959 1,382 6,029,000 3,610,000 25. 1,600,000,000 1,600 108
25. (a) 1,204,125,000 1,204 43,928 45,132 (b) (617,500,000) (617) (617) (c) 613,375,000 613 (613) (d) 400,000,000 400 67,208 67,608 (3,868) (3,868) 1,600,000,000 1,600 106,655 108,255 a. 50,000 50,000,0000.001Genscript Holdings (Cayman) Limited GS GSGS14,727,000 GS313,749,9990.001 GSGS21,158,000 GS BVIGS245,170,0010.001 0.001GS8,580,000 8,580,000 0.001GS586,625,000 617,500 b. GS 617,500,000617,500 c. 613,375 613,375,000 d. 1.310.001400,000,000 524,000,00067,608,000 109
26. GS Corp GS Corp 11 6,150,000 0.0060.040 10 Genscript Holding (Cayman) Limited Corporation GSGS GS CorpGS6,692,730 GS GS148,845,690167 0.0050.200 10170GS 155,538,420 GS GSGS 155,538,420 GS GS586,625,000GS 617,500,000 613,375 613,375,000GS 110
26. GS 0.1362 127,463 0.1374 61,103 0.1549 28,600 0.1351 66,360 0.1500 (525) 146,723 0.0718 302,261 0.1362 127,463 * 12,270 0.0026 2008/05/12 2019/12/31 2,672 0.0031 2007/12/31 2016/10/01 2,672 0.0041 2007/12/31 2016/10/01 770 0.0046 2009/07/03 2019/07/31 1,389 0.0072 2008/03/03 2019/07/31 2,993 0.0077 2010/01/15 2019/12/31 1,710 0.0103 2010/03/28 2018/01/15 823 0.0139 2011/12/08 2019/07/31 4,532 0.0154 2010/01/01 2019/12/20 898 0.0185 2010/01/05 2019/07/31 1,607 0.0206 2012/12/31 2019/08/10 5,450 0.0257 2010/12/31 2019/12/31 394 0.0515 2013/08/10 2025/07/31 45,279 0.0617 2014/12/31 2025/07/31 48,585 0.0772 2009/12/31 2025/07/31 67,941 0.1029 2011/07/15 2025/07/31 199,985 111
26. * 6,314 0.0050 2008/05/12 2019/12/31 1,375 0.0060 2007/12/31 2015/10/01 1,375 0.0080 2007/12/31 2015/10/01 396 0.0090 2009/07/03 2019/07/31 715 0.0140 2008/03/03 2019/07/31 1,540 0.0150 2010/01/15 2019/12/31 880 0.0200 2010/03/28 2018/01/15 423 0.0270 2011/12/08 2019/07/31 1,919 0.0300 2010/01/01 2019/12/20 462 0.0360 2010/01/05 2019/07/31 552 0.0400 2012/12/31 2019/08/10 2,804 0.0500 2010/12/31 2019/12/31 183 0.1000 2013/08/10 2025/07/31 11,600 0.1200 2014/12/31 2025/07/31 13,383 0.1500 2009/12/31 2025/07/31 33,712 0.2000 2011/07/15 2025/07/31 77,633 * 3,647,7510.1305,879,4350.089 3,348,000 3,284,000 (%) 0 0 (%) 43~48 47~48 (%) (%) 1.50~1.94 2.23~2.73 2.88~5.38 3.38~5.67 1.86 1.28~1.56 112
26. GS302,260,940 302,260,940302,261 21,410,568 GS297,463,271 17.9% 27. 6364 10%50% 25% 28. 878 874 3,506 1,910 110 4,494 2,784 113
29. 28 47 40 30. Genscript USA Corporation GS Corp (a) (i) 23 34 (ii) 7,776 (iii) 8,172 (i) (ii) 5.8 (iii) 114
30. (b) (i) GS Corp 34 (ii) GS Corp 2,570 (iii) 1 (i) 8,172 8,173 (i) (c) 1,559 1,424 25 23 1,216 2,181 2,800 3,628 8 30(a) 14A 115
31. 16,914 8,784 103,720 202 129,620 2,414 7,471 9,885 116
31. 2,526 2,526 12,157 12,157 284 284 34 34 25,637 25,637 345 345 38,457 2,526 40,983 2,869 3,435 8,173 2,570 17,047 32. 117
32. 2,526 2,526 118
33. 3%4%2% 3% % 5 698 (5) (698) 5 433 (5) (433) 119
33. 18 19 120
33. 41 2,373 2,414 424 7,047 7,471 465 9,420 9,885 105 2,764 2,869 339 3,073 23 3,435 2,570 2,570 8,173 8,173 8,617 8,407 23 17,047 121
33. 2,570 8,173 10,743 149,248 61,747 * 0% 17.4% 34. (a) 1.3160,000,000 78,600,00010,086,000 (b) 114,797,669 35. 2.2622 122
36. 44,246 44,246 8,520 50 65,148 73,718 3,607 3,356 6,963 66,755 111,001 111,001 1,600 109,401 111,001 123
36. 5,013 5,013 (5,615) (5,615) 43,928 43,928 (613) (613) 67,208 67,208 (3,868) (3,868) 3,348 3,348 106,655 8,361 (5,615) 109,401 2.4 37. 124
* 於開曼群島註冊成立的有限公司 股份代號 1548 * 2015 年度報告 * 僅供識別