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Frost & Sullivan

99% Lundbeck Export A/S Dr. Falk Pharma GmbH Lundbeck Export A/S Dr. Falk Pharma GmbH 46.1% 95%2,880,000 90% 3,200,000 90%10% 90% 500,00010% 45,0005% 85% 5%

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XV C. 3. 13.51(2) 44 50 CMS024 HealthlinkHealthlink Healthlink Healthlink CMS024 CMS024 CMS024 CMS024 HealthlinkHealthlink 38 CMS

513,000 533,000 516,000 240,000 8 499,000 484,000 493,000 474,000 244,000

(i) (ii)(iii) (iv) 3A.19 3A.23 (a) (b) (c) (d) 13.10 13.46

100,000,000 20,000,000,000 0.005 953,691,440 4,768,457.20 84.9% 170,000,000 850,000.00 15.1% 1,123,691,440 5,618,457.20 100.0% 953,691,440 4,768,457.20 82.4% 190,000,000 950,000.00 16.4% 14,173,900 70,869.50 1.2% 1,157,865,340 5,789,326.70 100.0%

1.0 6.9 14,173,900 0.005 1.2 148,825.95 20% 738,222 A. 3. 10% A. 5.

A. 3. (i) (ii)(iii) 20% (i) (ii) (iii) 0.5% 3%

(i) (ii) 451,000 104,000 162,52811,835 14 21 20

0.1020 0.005 100,000,000 20,000,000,000 0.005 0.10 0.005 1... 1.39 1.31 1.39 1.38... 1.41 1.39 1.39 1.40... 1.39 1.37 1.37 1.38... 1.37 1.37 1.37 1.37... 1.44 1.37 1.44 1.39... 1.43 1.42 1.42 1.43... 1.42 1.42 1.42 1.42 1... 1.43 1.21 1.21 1.36... 1.21 1.18 1.18 1.20... 1.18 1.02 1.02 1.08... 1.05 0.99 1.00 1.01... 1.06 0.99 1.06 1.02... 1.11 1.04 1.11 1.06... 1.27 1.15 1.22 1.22... 1.25 1.22 1.24 1.23... 1.27 1.24 1.27 1.24... 1.27 1.12 1.12 1.18... 1.17 1.12 1.14 1.15... 1.17 1.02 1.13 1.11

1... 1.22 1.15 1.18 1.19... 1.19 1.18 1.19 1.19... 1.19 1.17 1.19 1.19... 1.20 1.19 1.20 1.19... 1.70 1.19 1.47 1.46... 1.61 1.46 1.55 1.54... 2.27 1.48 2.22 1.65... 2.29 2.12 2.27 2.23... 2.34 2.21 2.31 2.26... 3.66 2.29 3.66 2.78... 4.18 3.30 3.83 3.80... 4.83 3.90 4.75 4.56 1... 5.75 4.78 5.73 5.40... 5.85 4.48 5.15 5.34... 5.00 4.43 4.65 4.72... 6.38 4.63 6.38 5.61... 6.35 5.90 6.00 6.04... 6.38 6.00 6.38 6.18... 0.36 0.35 0.35 0.35... 0.51 0.28 0.40 0.41... 0.48 0.34 0.43 0.48... 0.51 0.48 0.51 0.49 1. 0.1020 0.005 0.10 0.005

0.10 20 0.005... 0.07 0.07 0.07 0.07... 0.07 0.07 0.07 0.07... 0.07 0.07 0.07 0.07... 0.07 0.07 0.07 0.07... 0.08 0.07 0.08 0.07... 0.08 0.07 0.07 0.08... 0.07 0.07 0.07 0.07... 0.08 0.06 0.06 0.07... 0.06 0.06 0.06 0.06... 0.06 0.05 0.05 0.06... 0.06 0.05 0.05 0.05... 0.05 0.05 0.05 0.05... 0.06 0.05 0.06 0.06... 0.07 0.06 0.06 0.06... 0.07 0.06 0.06 0.06... 0.07 0.06 0.07 0.06... 0.07 0.06 0.06 0.06... 0.06 0.06 0.06 0.06... 0.06 0.05 0.06 0.06... 0.06 0.06 0.06 0.06... 0.06 0.06 0.06 0.06... 0.06 0.06 0.06 0.06... 0.06 0.06 0.06 0.06... 0.09 0.06 0.08 0.08... 0.08 0.08 0.08 0.08... 0.12 0.08 0.12 0.09... 0.12 0.11 0.12 0.12... 0.12 0.11 0.12 0.12... 0.19 0.12 0.19 0.14... 0.22 0.17 0.19 0.20... 0.24 0.20 0.24 0.23... 0.29 0.24 0.29 0.27... 0.29 0.22 0.26 0.27... 0.25 0.22 0.23 0.24... 0.32 0.23 0.32 0.28... 0.32 0.30 0.30 0.30... 0.32 0.30 0.31 0.32

1... 6,430 8,950... 17,652 24,624... 844 1,160... 141 194... 16,786 23,623... 4,006 5,726... 175 205 1... 3,287 4,309... 204 243... 6,195 6,408... 3,594 3,726... 32,239 32,053... 9,233 9,756... 7,226 8,854... 1,085 1,336... 2,079 2,593... 47,193 54,880... 3,751 4,360... 6,999 7,667 1... 3,152 3,749... 1,769 2,098... 440 524... 4,484 5,368... 15,015 22,030... 7,056 10,983... 13,539 26,159... 8,604 19,223... 5,053 11,585... 31,308 90,003... 17,668 66,835... 9,940 43,935 1... 8,419 45,822... 5,975 29,629... 5,450 25,276... 9,630 53,818... 5,999 34,138... 5,254 32,476... 8,367 2,942... 151,792 62,907... 145,645 63,454... 241,352 118,556 1. 0.1020 0.005 0.10 0.005

Frost & Sullivan 18% 950 306,000 97% 86% 91.5%34.6% 100,000 CNS 35,000 40,000

79.0% 79.6% 75.5% 70.2% 90.9% 95.1% 96.2% 94.0% Frost & Sullivan 28.8% 47.6% 100%CMS024 Dr. Falk Pharma GmbH Frost & Sullivan

* Frost & Sullivan 21.9%5% 20.7% 1,107 Frost & Sullivan 38% Frost & Sullivan 231 542 53.1% Frost & Sullivan 46Frost & Sullivan *

UDCA 98.0% 55.9% (AMD) rhbnp (AAD) 11.9% 16.3% 21.9% 22.9% 35.3% 25.4% 38.0% 32.4% 300 6,000 1717 9 51.7 72.6 96.5 61.236.5% 30.8% 33.6 44.8 60.9 37.2 34.6% 25.6% 64.9% 61.7% 63.1% 60.8% 8.7 15.0 20.8 15.3

55.0% 45.2%16.8% 20.7% 21.6% 25.1% (i) (ii) Healthlink Healthlink Healthlink 82.1% Healthlink17.9% Healthlink 1,969,0008,487,157 17.9% Healthlink 38,921,747 Healthlink HealthlinkHealthlink 1

51.7 96.536.5% 61.2 30.8% 11.9% 16.3% 21.9% 22.9%

16.2% 23.0% 22.6% 22.1% 25% 25%

92,000 119,000 10,000 116,000 0.8 5 15% 20 0.6 7.6 6.5 5.8

0.6 0.6 0.4 0.4 14.5 17.2 20.7 28.9 44,000 23,000 57,000 21,000 0.3 0.2 0.2 0.2

60.08.8 10 6.00.9 7,500,0001,098,00024.5% 6.0 1,500,000219,000 5.0% 5.0%6.8 0.2 0.3 0.1 6.9 6.1 5.8

% % % % %... 47,013 90.9 69,595 95.9 93,752 97.2 45,188 96.6 60,389 98.7.. 4,734 9.1 3,005 4.1 2,702 2.8 1,587 3.4 806 1.3... 51,747 100.0 72,600 100.0 96,454 100.0 46,775 100.0 61,195 100.0... 17,753 97.8 27,358 98.3 35,333 99.3 17,004 99.2 23,684 98.8... 396 2.2 477 1.7 263 0.7 135 0.8 286 1.2... 18,149 100.0 27,835 100.0 35,596 100.0 17,139 100.0 23,970 100.0... 29,260 87.1 42,237 94.4 58,419 96.0 28,184 95.1 36,705 98.6... 4,338 12.9 2,528 5.6 2,439 4.0 1,452 4.9 520 1.4... 33,598 100.0 44,765 100.0 60,858 100.0 29,636 100.0 37,225 100.0

Synda Limited Synda Limited Synda Limited10 Synda Limited 4% 6%Synda Limited 36.7%Synda LimitedSunpharma GmbH20% Sunpharma GmbHSynda Limited Synda Limited0.2 0.2 0.5 0.2 (i) (ii) 64.9% 61.7% 63.1% 60.8%

% % % % %... 771 1.1.. 655 1.3 743 1.0 (405) (0.4) (272) (0.6) (109) (0.2)... 1 623 0.9 801 0.8 161 0.3 240 0.4... 236 0.5 221 0.3 329 0.3 94 0.2 302 0.5.. 24.. (70) (0.1)... 288 0.6 158 0.2 81 0.1 14 81 0.1... 30 20... (8) 2 7 (2) 6... (805) (0.8).. 647 0.7 647 1.4... 78 0.1 152 0.2 53 0.1 49 0.2 26 0.1... 1,280 2.5 2,690 3.7 662 0.7 691 1.5 546 0.9

% % % % %... 6,293 12.2 7,743 10.7 10,042 10.4 4,432 9.5 5,735 9.4... 5,549 10.7 7,870 10.8 9,843 10.2 4,475 9.6 4,732 7.7... 1,008 1.9 1,376 1.9 2,556 2.6 1,284 2.7 1,392 2.3... 1,084 2.1 1,642 2.3 2,399 2.6 1,175 2.5 1,459 2.4... 13,934 26.9 18,631 25.7 24,840 25.8 11,366 24.3 13,318 21.8 % % % % %... 2,555 4.9 2,983 4.1 3,335 3.5 1,562 3.3 1,336 2.2.. 1,280 2.5 1,317 1.8 1,347 1.4 847 1.8 713 1.2... 353 0.7 551 0.8 588 0.6 171 0.4 130 0.2... 591 1.1 498 0.7 598 0.6 343 0.7 434 0.7... 1,168 2.3 1,591 2.2 1,531 1.6 985 2.2 661 1.1... 5,947 11.5 6,940 9.6 7,399 7.7 3,908 8.4 3,274 5.4

51% 3.051% 70,000 18 73.5% 49.0%24.5% 55% 45% 55%

1.7 4.5 6.1 4.4 16.2%, 23.0%, 22.6% 22.1% 25%... 15% (1) 18% 20% 20% 22%... 15% (1) 18% 20% 20% 22% (2)... 15% 15% 15% 15% 15%... 25% 25% 25% 15% (3) (1) 15% (2) 15% 15% (3) 15%

% % % % % ()... 51,747 100.0 72,600 100.0 96,454 100.0 46,775 100.0 61,195 100.0... (18,149 ) (35.1) (27,835) (38.3) (35,596 ) (36.9) (17,139) (36.6) (23,970 ) (39.2 )... 33,598 64.9 44,765 61.7 60,858 63.1 29,636 63.4 37,225 60.8... 1,280 2.5 2,690 3.7 662 0.7 691 1.5 546 0.9... (13,934 ) (26.9) (18,631) (25.7) (24,840 ) (25.8) (11,366) (24.3) (13,318 ) (21.8 )... (2,773) (5.4) (1,221) (2.0 )... (5,947) (11.5) (6,940) (9.6) (7,399) (7.7) (3,908) (8.4) (3,274) (5.4 )... (1,633) (3.2) (2,275) (3.1) (2,038) (2.1) (1,057) (2.3)... (301) (0.6) (226) (0.3) (390) (0.4) (191) (0.4) (336 ) (0.5 )... 56 0.2 152 0.2 30 0.0 (26) (0.1) 42 0.1... 43 0.1 21 0.1 25 0.1... 10,346 20.0 19,535 26.9 26,926 27.9 13,800 29.5 19,689 32.2... (1,672) (3.2) (4,487) (6.2) (6,096) (6.3) (3,243) (6.9) (4,355) (7.1 )... 8,674 16.8 15,048 20.7 20,830 21.6 10,557 22.6 15,334 25.1... 1,639 3.2 2,880 4.0 70 0.1 19 497 0.8 36 (1) (5)... (145) (0.2) 32 0.1... 10,313 19.9 17,964 24.7 20,754 21.5 10,576 22.6 15,858 25.9... 8,685 16.8 14,946 20.6 20,684 21.4 10,448 22.4 15,230 24.9... (11) (0.0) 102 0.1 146 0.2 109 0.2 104 0.2 8,674 16.8 15,048 20.7 20,830 21.6 10,557 22.6 15,334 25.1... 10,335 20.0 17,877 24.6 20,608 21.3 10,467 22.4 15,754 25.7... (22) (0.1) 87 0.1 146 0.2 109 0.2 104 0.2 10,313 19.9 17,964 24.7 20,754 21.5 10,576 22.6 15,858 25.9

% % % % %... 26,144 50.5 36,710 50.6 44,468 46.1 22,768 48.7 26,029 42.5... 14,756 28.5 21,074 29.0 28,327 29.4 13,393 28.6 16,937 27.7... 3,011 5.8 4,394 6.1 6,146 6.4 2,817 6.0 3,814 6.2... 2,599 5.0 3,910 5.4 4,780 5.0 2,243 4.8 2,004 3.3... 2,839 3.9 7,253 7.5 2,983 6.4 5,697 9.3... 66 0.1 515 0.4 171 0.4 319 0.5... 133 0.2 1,824 1.9 658 1.4 1,684 2.8... 3,367 5.5... 282 0.5... 503 1.1 469 0.6 439 0.5 155 0.3 256 0.4 47,013 90.9 69,595 95.9 93,752 97.2 45,188 96.6 60,389 98.7... 4,689 9.1 2,950 4.1 2,571 2.7 1,546 3.3 806 1.3... 45 55 131 0.1 41 0.1 4,734 9.1 3,005 4.1 2,702 2.8 1,587 3.4 806 1.3 51,747 100.0 72,600 100.0 96,454 100.0 46,775 100.0 61,195 100.0 46.830.8% 61.2 45.2 33.6%60.4 22.814.3% 26.0 13.426.5% 16.9

77.3% 70.2% 2.835.4%3.8 2.210.7% 2.0 3.091%5.7 0.286.5% 0.3 0.7155.9%1.7 3.4 5.5% 0.3 0.5% 24.0% 1.6 49.2%0.8 3.4% 1.3% 17.139.9% 24.0 29.625.6% 37.2 63.4%60.8%

0.721.0% 0.50.6 0.3 CMS024 0.2 11.417.2% 13.3 (i) 4.429.4% 5.7 (ii) 4.55.7%4.7(iii) 24.3%2.5% 21.8% 1.2 3.916.2% 3.3(i) Healthlink 0.2 (ii)0.2 (iii)0.3 0.1 8.4%3.0% 5.4% Healthlink HealthlinkHealthlink 0.275.9% 0.3 0.2

42,000 51% 24.5% 45,00026,000 19,000 24.5% 42,000 25,000 21,000 3.234.3% 4.4 20% 22% 25% 15% 23.5% 22.1% 10.6 45.2%15.3 22.6% 25.1% 72.632.9% 96.5 69.634.7% 93.8 36.721.1% 44.5 21.134.4% 28.3 4.439.9% 6.1

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6.96.6% 7.4 9.6%1.9% 7.7% 2.310.4% 2.0 Healthlink 2.0 1.6 0.272.6% 0.4 0.3 24.5% 0.1 51% 0.1 43,000 4.535.9% 6.1 18% 20% 23.0% 22.6% 15.038.4% 20.8 20.7%21.6% 51.740.3% 72.6 47.048.0% 69.6

26.140.4% 36.7 14.842.8% 21.1 3.045.9% 4.4 2.650.4% 3.9 0.1 0.1 2.8 4.736.5% 3.0 9.1%4.1% 18.153.4% 27.8 (i) (ii) 33.633.2% 44.8 64.9%61.7%(i) (ii) (a) (b) 1.3110.2%2.7 Dr. Falk Pharma GmbH0.8 CMS024 0.6 13.933.7% 18.6 (i) 6.323.0% 7.7 (ii) 5.541.8% 7.9 (iii) 26.9%1.2% 25.7%

2.8 5.916.7% 6.9 (i) 2.6 16.8% 3.0 (ii) (iii) 11.5%1.9% 9.6% 1.639.3% 2.3 Healthlink 1.3 2.0 0.324.9% 0.2 0.3 0.2 51% 0.1171.4% 0.2 1.7168.4% 4.5 15%18% 5% 16.2%23.0% 8.773.5% 15.0 16.8%20.7%

... 6,572 10,175 15,549 9,369 4,673... (1,861) (1,744) (16,616) (5,800) (2,812)... 3,072 (7,219) (4,022) (5,564) (6,937)... 7,783 1,212 (5,089) (1,995) (5,076)... 8,948 17,601 20,100 20,100 15,113... 17,601 20,100 15,113 18,129 10,340 4.7 7.9 3.2 7.919.7 11.8 2.213.9 (a) 6.4 (b) 8.3 (c)0.4 1.2

9.4 11.72.3 11.713.8 2.1 0.52.7 (a) 2.8 (b)3.0 3.2 15.5 20.7 5.2 20.726.9 6.2 2.38.5 (a)5.2 (b) 5.3 2.3 10.2 13.9 3.7 13.919.5 5.6 1.67.2 (a) 7.5 (b) 5.0 (c)5.3 6.6 8.7 2.1

8.710.3 1.6 3.65.2 (a)9.0 (b) 4.5 (c) 7.7 2.8 2.9 0.2 0.10.3 0.1 5.8 5.1 24.5% 0.9 0.1 0.1 16.6 16.624.5% 0.9 0.3 51%0.4 0.3 0.2 0.1 1.7 1.1 1.0 0.1 0.2 51% 0.2 1.9 0.8 51% 0.860%100% 0.5 0.2

6.9 (i)4.7 (ii)1.4 (iii) 0.5(iv) 0.2 (v) 40% 0.2 598.9 8.8 11,8350.100.1 5.6 4.70.7 0.1 4.0 Healthlink10.1 9.51.2 0.2 16.51682.78 162,5280.100.5 7.2 7.1 0.1 3.1 138 2.76 7,246,376 0.10 20.0 5.8 12.9 5.1 4.30.3

... 10,677 5,945 11,060 17,437 15,497... 19,305 27,684 32,794 41,485 43,899... 164 172... 481 506 772... 20 43... 31 406 7... 324 253... 18 4... 1,060 17,641 17,792 13,870... 17,601 20,100 15,113 10,340 7,639 47,767 55,004 77,120 88,308 81,941... 12,920 9,252 11,062 12,235 6,671... 5... 16,517 16,346 12,548... 685 838 811 811... 145 131 138... 180 813 1,226 1,848 375 13,100 10,755 29,788 31,371 20,543... 34,667 44,249 47,332 56,937 61,398... 164 46 222 97... 27 104 32 35... 10,486 5,795 10,806 17,305... 10,677 5,945 11,060 17,437 (1)... 124 109 87 109 (1) 365 183

92,000 119,000 10,000 116,000 11.1 17.4 (i) (ii) 5.9 11.1 (i) (ii) 10.7 5.9 79 109 10987 124109 26.8%

... 14,785 17,441 20,959 29,166... (307) (221) (213) (235)... 14,478 17,220 20,746 28,931... 2,669 7,062 9,513 8,910... 2,158 3,402 2,535 3,644... 19,305 27,684 32,794 41,485 (1)... 86 81 73 75 (1) 365183 6 14.5 17.2 17.2 20.7 20.7 28.9 (i) (ii) 79 73 75 79

8681 73 79 75 0.3 0.2 0.2 0.2 2.1% 1.3% 1.0% 0.8% 0.1 0.1 0-90... 1,797 2,127 2,274 3,004 91-365... 2,184 2,071 2,174 2,896 365... 126 93 28 29 4,107 4,291 4,476 5,929... 10,371 12,929 16,270 23,002... 14,478 17,220 20,746 28,931 30.7%

0-90... 1,272 5,562 6,067 4,299 91-365... 9,122 24 5 1 365... 7 7 7 7 10,401 5,593 6,079 4,307 (1)... 131 105 60 40 (1) 365183 10.4 5.6 0 120 131105 105 60 60 90 7640

12 12.5 5.8 (1)... 16,517 16,346 12,548... 685 838 811 811... 6,179 5,291 4,986 5,020 (1) 12,548,000 13,533,000 337,000 1.531.87 0.581.620.250.89 1.62 31 5,667,000 164,000 18.2% 15.8%

16.0 90.0 16.0 90.0 16.0 30 90.0 20 16 90... 795 959 280 101... 2,919... 795 959 280 3,020 0.8 1.0 0.3 3.0 176,000

1 1-5 5... 6,439 6,439... 884 3,699 2,575 7,158... 6,003 6,003... 10,520 10,520... 23,846 3,699 2,575 30,120 41

75.1% 70.1% 76.4% 81.7% 10.4

4.29 (1) (2) (3) 3.60... 58,789 73,219 132,008 0.12 0.91 5.06... 58,789 104,687 163,476 0.15 1.13 (1) 64,954,000 6,165,000 (2) 170,000,0003.60 5.06 7.77 1 (3) 1,123,691,440 25% 50%

2.4 4.7 3.3 4.7 4.7 1.4 10.78.7 Healthlink 2.0Healthlink Healthlink

7,457,000 (1)... 30 233 (2)... 2.7 20.8 1. 2. 1,123,691,440 1 7.77 13.13 13.19 13.13 13.19

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(xv) (xvi) (1) (2) (3) (4) (b) (i) (ii) (iii) (iv)

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(a) (b) (c) (d) 30 155 (a) (b)

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15.

London Stock Exchange plc CMS 10,000 100% 100% 100% 100% 100% CMS 1 CMS Peptides Patent Holding 100 70% 70% Company Limited 2 CMS Peptides Healthlink Consultancy Inc. 474,089 100% 100% Healthlink 2 100% 100% 100% 100% 100% 20,000,000 70% 70% 3,660,000 3 3 2

100% 100% 100% 100% 100% 10,000,000 100% 100% 100% 100% 100% 21,288,000 100% 100% 1,300,000 4 100% 100% 100% 100% 100% 150,000,000 100% 100% 10,609,000 2 1 100% 100% 100% 100% 100% 10 60% 60% 60% 100% 100% Crosspac Group Limited 10 70% 70% Crosspac 3 3 2 100% 100% 100% 100% 2,000,000 CMS 1 100% 100% 100% 100% CMS 1. CMS 2. Healthlink CMS Peptides CrosspacHealthlink 3. 4. 39(b)

..................

3.340 1 1 2410

A.... 5 51,747 72,600 96,454 46,775 61,195... (18,149) (27,835) (35,596) (17,139) (23,970)... 33,598 44,765 60,858 29,636 37,225... 6 1,280 2,690 662 691 546... (13,934) (18,631) (24,840) (11,366) (13,318)... (2,773) (1,221)... (5,947) (6,940) (7,399) (3,908) (3,274)... (1,633) (2,275) (2,038) (1,057)... 7 (301) (226) (390) (191) (336)... 56 152 30 (26) 42... 43 21 25... 10,346 19,535 26,926 13,800 19,689... 9 (1,672) (4,487) (6,096) (3,243) (4,355)... 10 8,674 15,048 20,830 10,557 15,334... 1,639 2,880 70 19 497. 36 (1) (5)... (145) 32. 10,313 17,964 20,754 10,576 15,858... 8,685 14,946 20,684 10,448 15,230... (11) 102 146 109 104 8,674 15,048 20,830 10,557 15,334... 10,335 17,877 20,608 10,467 15,754... (22) 87 146 109 104 10,313 17,964 20,754 10,576 15,858 13... 0.993 1.582 2.186 1.106 1.608... 0.992 1.582 2.174 1.106 1.590

... 14 4,940 5,459 3,575 3,310... 15 257 267 260 3,098... 17 43 68... 18 198 535 1,507 1,498... 19 162... 20 610 7,575 6,461 5,786... 21 581 581 379 379... 22 429 1,073 1,432 1,153 7,177 15,490 13,657 15,292... 23 10,677 5,945 11,060 17,437... 24 19,305 27,684 32,794 41,485... 25 164 172... 25 481 506... 25 20 43... 26 31 406... 324... 31 18... 27 1,060 17,641 17,792... 27 17,601 20,100 15,113 10,340 47,767 55,004 77,120 88,308... 28 12,920 9,252 11,062 12,235... 5... 29 16,517 16,346... 30 685 838 811... 31 145 131... 180 813 1,226 1,848 13,100 10,755 29,788 31,371... 34,667 44,249 47,332 56,937... 41,844 59,739 60,989 72,229... 32 4,725 4,725 4,741 4,768... 34 37,275 48,065 48,992 60,186... 42,000 52,790 53,733 64,954... 35 (156) (69) 201 41,844 52,721 53,934 64,954... 22 839 1,764 2,289... 30 6,179 5,291 4,986 7,018 7,055 7,275 41,844 59,739 60,989 72,229

... 16 20 20 10 10... 195... 25 22,363 13,589 18,469 14,281... 2 34 13 31 22,365 13,623 18,482 14,507... 153 182 142 13... 5... 25 945 1,098 187 142 13... 21,267 13,436 18,340 14,494... 21,287 13,456 18,350 14,504... 32 4,725 4,725 4,741 4,768... 34 16,562 8,731 13,609 9,736 21,287 13,456 18,350 14,504

34 33 34 34.. 2 8,909 2,433 845 1,080 (46) 13,223 (138) 13,085... 1,650 1,650 (11) 1,639... 8,685 8,685 (11) 8,674... 1,650 8,685 10,335 (22) 10,313... 3,998 (3,998)... 725 19,264 19,989 19,989... (570) 570... (1,547) (1,547) (1,547)... 4 4... (4,725) 4,725... 1,822 (845) (977)... 4,725 17,147 4,911 570 4,255 2,730 2,937 4,725 42,000 (156) 41,844

34 33 34 34...... 4,725 17,147 4,911 570 4,255 2,730 2,937 4,725 42,000 (156) 41,844... 2,895 2,895 (15) 2,880... 36 36 36... 14,946 14,946 102 15,048... 2,931 14,946 17,877 87 17,964... (2,362) (4,725) (7,087) (7,087)... (4,725) 4,725... 1,802 (1,802)... 4,725 17,147 4,911 570 6,057 5,661 8,994 4,725 52,790 (69) 52,721

34 33 34 34... 4,725 17,147 4,911 570 6,057 5,661 8,994 4,725 52,790 (69) 52,721... 70 70 70... (1) (1) (1)... (145) (145) (145)... 20,684 20,684 146 20,830... 69 (145) 20,684 20,608 146 20,754... 16 435 451 451... 8 (8)... (36) 36... (206) (206)... (11,503) 853 (10,650) 330 (10,320)... (4,741) (4,725) (9,466) (9,466)... (4,741) 4,741... 2,102 (2,102)... 4,741 6,079 4,911 570 8,159 6,555 (145) 18,122 4,741 53,733 201 53,934 2010

34 33 34 34... 4,725 17,147 4,911 570 6,057 5,661 8,994 4,725 52,790 (69) 52,721... 19 19 19... 10,448 10,448 109 10,557... 19 10,448 10,467 109 10,576... (4,725) (4,725) (103) (4,828) (4,725) 4,725... 1,339 (1,339) 4,725 17,147 4,911 570 7,396 5,680 13,378 4,725 58,532 (63) 58,469

34 33 34 34... 4,741 6,079 4,911 570 8,159 6,555 (145) 18,122 4,741 53,733 201 53,934... 497 497 497... (5) (5) (5)... 32 32 32... 15,230 15,230 104 15,334... 492 32 15,230 15,754 104 15,858... 1 103 104 104... 26 2,299 2,325 2,325... (2,221) (2,221) (104) (2,325)... (201) (201)... (4,741) (4,741) (4,741)... 1,068 (1,068)... 4,768 8,481 2,690 570 9,227 7,047 (113) 32,284 64,954 64,954

... 10,346 19,535 26,926 13,800 19,689... (56) (152) (30) 26 (42)... (43) (21) (25)... (647) (647)... 20 59 793 1,115 585 419. 14 637 772 898 445 380... 6 7 7 4 33... (236) (221) (329) (94) (302)... (30) (20)... 301 43 187... 226 347 191 149... 2,773 1,221... 8 (2) (7) 2 (6)... 805... (24)... 70... 92 119 10 8 116... 44 23 57 32 21... 13,944 21,080 29,198 14,331 21,840... (8,986) 5,347 (5,226) (2,840) (6,432)... (4,545) (7,526) (5,287) (2,976) (8,255)... (31) (375)... (56) (8) 172 3... (481) (25). 624 (23) 43 (18)... 7,734 (5,011) 2,284 3,174 1,180... (6)... 8,709 13,859 20,672 11,674 7,933... (2,111) (3,637) (5,008) (2,300) (3,254)... (26) (47) (115) (5) (6)... 6,572 10,175 15,549 9,369 4,673

... (795) (959) (280) (59) (101)... (2,919) 19... 20(a) (770)... (149)... 38 (537)... (1,060) (16,581) (5,069) (151)... 236 221 329 94 302... 235 46... 187... 5 16 120 111 11... 39(b) (1)... 439... (877) (877)... (1,861) (1,744) (16,616) (5,800) (2,812)... (7,082) (9,471) (4,730) (4,741)... 39(a) (10,068)... (137) (1,245) (731) (512)... 19,989 451 104... 5,757 16,517 2,555... (4,320)... (1,416)... (12,905) (2,726)... (5,148)... (301)... (206) (103) (201)... 3,072 (7,219) (4,022) (5,564) (6,937)... 7,783 1,212 (5,089) (1,995) (5,076)... 8,948 17,601 20,100 20,100 15,113... 870 1,287 102 24 303... 17,601 20,100 15,113 18,129 10,340

1. London Stock Exchange plc Treasure Sea Limited PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman IslandsA 8 CMS VI 2. 3 27 3 27 32 2,221,000 1 24 4 32 2 1 7 3 9 5 IFRIC* 14 4 IFRIC19 3 * IFRIC 1

2 3 4 5 3.

3 12 19 2 5

4. 610,000 7,575,000 6,461,000 5,786,00020 429,000 1,073,000 1,432,000 1,153,000 581,000 581,000 379,000 379,00021 14,478,000 17,220,000 20,746,000 28,931,000 307,000 221,000 213,000 235,000

5. 8 8 8,000 622,000 1,334,000 3,000 280,0002,022,000 8 (1) (2)

... 47,013 4,734 51,747... 3,841 (3,841)... 47,013 8,575 (3,841) 51,747... 29,260 4,338 33,598... 1,280... (13,934)... (2,773)... (5,947)... (1,633)... (301)... 56... 10,346... 69,595 3,005 72,600... 4,496 (4,496)... 69,595 7,501 (4,496) 72,600... 42,237 2,528 44,765... 2,690... (18,631)... (6,940)... (2,275)... (226)... 152... 19,535

... 93,752 2,702 96,454... 2,100 (2,100)... 93,752 4,802 (2,100) 96,454... 58,419 2,439 60,858... 662... (24,840)... (7,399)... (2,038)... (390)... 30... 43... 26,926... 45,188 1,587 46,775... 484 (484)... 45,188 2,071 (484) 46,775... 28,184 1,452 29,636... 691... (11,366)... (3,908)... (1,057)... (191)... (26)... 21... 13,800

... 60,389 806 61,195... 430 (430)... 60,389 1,236 (430) 61,195... 36,705 520 37,225... 546... (13,318)... (1,221)... (3,274)... (336)... 42... 25... 19,689 3

... 59 366 271 696... 92 92... 793 392 380 1,565... 119 119... 1,115 391 507 2,013... 10 10... 585 125 320 1,030... 8 8... 419 147 233 799... 116 116

... 26,144 36,710 44,468 22,768 26,029... 14,756 21,074 28,327 13,393 16,937... 3,011 4,394 6,146 2,817 3,814... 2,599 3,910 4,780 2,243 2,004... 2,839 7,253 2,983 5,697... 133 1,824 658 1,684... 66 515 171 319... 3,367... 282... 5,237 3,474 3,141 1,742 1,062... 51,747 72,600 96,454 46,775 61,195 6.... 771... 655 743 (405) (272) (109)... 1 623 801 161 240... 236 221 329 94 302... 24 18... (70)... 288 158 81 14 81... 30 20... (8) 2 7 (2) 6 14... (805) 18... 647 647... 78 152 53 49 26 1,280 2,690 662 691 546

7.... 301 43 187... 226 347 191 149 301 226 390 191 336 8.... 188 193 161 77 81...... 308 328 340 173 151... 17 12 15 4 8 513 533 516 254 240

... 30 28 23 11 12... 84 89 87 41 46... 6 3 7 1 1 120 120 117 53 59... 30 28 23 11 12... 78 80 89 43 46... 3 3 3 1 2 111 111 115 55 60... 30 28 23 11 11... 62 65 50 36... 4 3 2 1 3 96 96 75 48 14... 29 28 23 11 11... 54 53 67 30 36... 4 3 3 1 2 87 84 93 42 49... 23 27 23 11 11... 30 41 47 23 23... 53 68 70 34 34

Paul Bernard Harper... 23 27 23 11 8...... 23 27 23 11 8 Stuart Hamilton Leckie... 23 27 23 11 11...... 23 27 23 11 11... 4...... 4... 1...... 1... 513 533 516 254 240

... 68 79 71 74... 2 3 3 2 70 82 74 76 1,000,000... 1 1 1 2

9.... 1,864 4,236 5,443 2,725 3,492... 21 63 97 66... 6 6 3 1,885 4,305 5,546 2,725 3,561... (6) (21) (11) (7) (11) 22... (169) 203 561 525 805... (38) (207) 203 561 525 805... 1,672 4,487 6,096 3,243 4,355 33% 30% 3% 63 15% 25%

15% 18% 20% 20% 22% 15% 15% 15% 15% Labuan Offshore Business Activity Tax Act 1990Labuan CMS 20,0006,000 3% CMS 17.5% 16.5% 17.5% 16.5% 16.5% 16.5% 16.5%

... 10,346 19,535 26,926 13,800 19,689... 1,552 3,516 5,385 2,760 4,332... (9) (4) (6)... (8) (27) (6) 5 (9)... 550 340 575 324 361... (337) (122) (52) (1) (17)... 104 438 223 154 19... (177) (78) (28) (4) (198)... 182 (265) (280) (131) (13) Labuan... (133) (629) (260) (627)... (6) (21) (11) (7) (11)... (169) (3) (2)... (38)... 839 925 409 525... 19 3 3 (2) 1... 1,672 4,487 6,096 3,243 4,355 15% 18% 20% 20% 22%

10.... 188 193 161 77 81... 308 328 340 173 151... 17 12 15 4 8 513 533 516 254 240... 7,633 10,668 13,082 5,658 5,656... 529 626 674 287 306 43)... 451 104... 8,675 11,827 14,723 6,199 6,306... 165 135 150 75 75 )... 2,773 1,221... 44 23 57 32 21... 92 119 10 8 116... 6 7 7 4 33... 637 772 898 445 380... 59 793 1,115 585 419... 17,413 25,753 34,078 16,349 23,255... 448 591 621 359 294 London Stock Exchange plc

11. 32 0.10... 2,362 4,741... 3,307 4,725 4,725 4,741... 1,418 7,087 9,466 4,725 4,741... 3,307 4,725 4,741... 1,418... 4,725 4,725 4,725 4,741 4,725 0.10 0.05 0.10 0.102,362,000 4,741,000 4,725,000 0.100.07 0.10 0.10 0.03 4,725,000 4,725,000 4,741,000 12. 0.10 Healthlink 39(a)... 8,681... 1,969 10,650

13.... 8,685 14,946 20,684 10,448 15,230... 874,647,599 944,927,520 946,290,084 944,927,520 946,963,529... 538,965 5,132,705 10,643,868... 875,186,564 944,927,520 951,422,789 944,927,520 957,607,397 32 39,980,000

14.... 2,298 18 2,447 886 757 527 6,933... 158 169 61 53 35 476... 177 75 281 256 6 795. 6 6... 20 548 (568)... (18) (16) (17) (51)... 2,476 177 3,223 1,228 1,055 8,159... 170 12 227 102 78 589... 112 614 233 959... (108) (32) (140)... 2,646 189 3,562 1,836 1,334 9,567... 2 4 2 1 9... 108 127 45 280... (32) (409) (24) (465)... (12) (12)... (926) (57) (983)... 2,648 189 2,716 1,556 1,287 8,396... 15 1 15 9 7 47... 51 50 101... (31) (1) (32)... 2,663 190 2,731 1,585 1,343 8,512

... 653 18 847 422 494 2,434... 50 65 33 38 186... 132 28 278 117 82 637... (18) (7) (13) (38)... 835 28 1,183 572 601 3,219... 62 4 92 41 44 243... 142 62 300 156 112 772... (97) (29) (126)... 1,039 94 1,575 672 728 4,108... 1 2 1 1 5... 135 63 291 262 147 898... (30) (305) (17) (352)... (6) (6)... (600) (37) (637)... 805 805... 1,175 157 2,043 630 816 4,821... 7 1 11 4 5 28... 63 32 84 129 72 380 (26) (1) (27)... 1,245 190 2,138 737 892 5,202... 1,641 149 2,040 656 454 4,940... 1,607 95 1,987 1,164 606 5,459... 1,473 32 673 926 471 3,575... 1,418 593 848 451 3,310 805,0006 15%

4.75% 18% 18% 18% 15.... 263 274 267 3,164... 6 7 7 66... 257 267 260 3,098 263 274 267 3,164 16.... 20 20 10 10

17.... 43 68 43 68 55% 55% 55%... 433 476 782 854... (459) (518) (704) (731)... (26) (42) 78 123... 43 68

... 525 1,179 224 580... (14) (14) 121 38 45... 43 21 25 18.... 229 378 1,687 1,687... (52) 157 (180) (189)... 21 198 535 1,507 1,498 51% 51% 1 2 24.49% 24.49%

(1) 51% 411,235,000 1,765,000 181,000 258,000 70,000 (2) 22,500,0003,295,000 73.47%18,000,000 2,636,000 4,500,000659,000 24.49% 7,500,0001,098,000 24.49% 38.78% 36.73% 7,500,0001,098,00024.49%6,000,000 879,000 1,500,000219,000 24.49% 647,000... 453 1,211 6154 6,117... (65) (161) (1)... 388 1,050 6,154 6,116... 198 535 1,507 1,498

... 1,084 1,654 2,170 907 175... 151 298 178 (9) 170... 71 (3) (23) 56 152 30 (26) 42... 36 (1) (5) 19. 51% 5,865,000770,000 2,550,000335,000 335,000126,000 1,329,000187,000 51% 20(b)

20. a b a(i)... 644 644... 27 27... 671 671... 78 78 a(ii)... 919 6,775 7,694... (717) 628 (89)... 951 7,403 8,354... 1 1... 952 7,403 8,355... 5 5 a(iii)... (258) (258)... 699 7,403 8,102... (59) (59)... (2) (2)... (61) (61)... (14) (14)... (302) (491) (793)... 89 89... (288) (491) (779)... (294) (821) (1,115)... (582) (1,312) (1,894)... (3) (3)... (49) (370) (419)... (634) (1,682) (2,316)... 610 610... 663 6,912 7,575... 370 6,091 6,461... 65 5,721 5,786

(a) (i) 19 644,000 770,000 126,000 10 (b) 628,000 (b) (ii) Lyophilized Recombinant Human Brain Natriuretic Peptide Nesiritide Nesiritide Nesiritide Nesiritide 2,000 Nesiritide 2,000 Nesiritide2,000 2,0006,500,000 919,000 Nesiritide Nesiritide 919,000 3 (iii) 2,000 1,755,000258,000

(b) Pharma Stulln GmbHPharma 1951% 60,000,000 8,779,000 CMS Pharma CMS 6,000,000878,000 30 6,775,000 105% 878,000 CMSPharma 10 21.... 581... 581... (202)... 379 379,000 202,000

10% 20% 15% 15% 22.... 222 222 9... 152 17 169 9... 38 38... 412 17 429 9... 653 (839) (17) (203)... 8 8... 1,073 (839) 234 9... 244 (925) 120 (561)... (5) (5)... 1,312 (1,764) 120 (332) 9... (268) (525) (12) (805)... 1 1... 1,045 (2,289) 108 (1,136) 14

... 429 1,073 1,432 1,153... (839) (1,764) (2,289) 429 234 (332) (1,136) 4,310,000 6,659,000 2,178,000 2,294,000 3,804,000 5,859,000 1,378,000 1,439,000 16,772,000 35,280,000 45,766,000 23.... 164 46 222 97... 27 104 32 35... 10,486 5,795 10,806 17,305 10,677 5,945 11,060 17,437

24.... 14,785 17,441 20,959 29,166... (307) (221) (213) (235) 14,478 17,220 20,746 28,931... 2,669 7,062 9,513 8,910... 2,158 3,402 2,535 3,644... 19,305 27,684 32,794 41,485 0 90 0-90... 12,164 14,811 17,879 25,640 91-365... 2,188 2,316 2,839 3,262 365... 126 93 28 29 14,478 17,220 20,746 28,931 4,107,000 4,291,000 4,476,000 5,929,000

0-90... 1,797 2,127 2,274 3,004 91-365... 2,184 2,071 2,174 2,896 365... 126 93 28 29 4,107 4,291 4,476 5,929... 244 307 221 213... 44 23 57 21... (127) (65)... 19 18 1... 307 221 213 235 307,000 221,000 213,000 235,000 25. (a)... 5... 3... 12 43 20 43

(b) 312,000 335,000 (a) (b) 26.... 31 406 27. 0.72% 5.00% 0.36% 5.00% 0.36% 1.71% 0.50% 2.25% 1,060,000 17,380,000 17,456,000 29 261,000 336,000

28. 0-90... 1,272 5,562 6,067 4,299 91-365... 9,122 24 5 1 365... 7 7 7 7 10,401 5,593 6,079 4,307... 1,049 1,564 2,239 2,052... 440 461 926 1,614... 1,030 1,634 1,818 4,262 12,920 9,252 11,062 12,235 0 120 29.... 7,557 5,906... 8,960 10,440 16,517 16,346... 16,517 16,346 1.531.87 1.391.87 0.35% 0.581.620.250.89

17,380,000 17,456,000 27 30.... 6,179 5,291 4,986... 685 838 811 6,864 6,129 5,797 60,000,000 8,779,000 20(b) 6,000,000 878,000 5% 6,775,000 6,864,000 5,966,000 5,633,000 18(2) 31.... 74 131... 71 (18) 145 113

(i) 3,765,000... 2010.09.28 1+0.35% 1.47% 1,470,000... 2010.11.29 3+0.35% 1.68% 1,617,000... 2010.12.14 3+0.35% 1.68% 2,108,000... 2010.12.30 3+0.35% 1.68% 3,765,000... 2010.09.28 1+0.35% 1.47% 1,470,000... 2010.11.29 3+0.35% 1.68% 1,617,000... 2010.12.14 3+0.35% 1.68% 2,108,000... 2010.12.30 3+0.35% 1.68% 1,481,000... 2011.02.09 3 1.68% (ii) 2,140,000... 2010.08.23 16.822 3,821,000... 2010.09.28 16.858 1,470,000... 2010.12.02 16.638 1,620,000... 2010.12.14 16.719 2,140,000... 2010.12.30 16.686 2,140,000... 2010.08.23 16.822 3,821,000... 2010.09.28 16.858 1,470,000... 2010.12.02 16.638 1,620,000... 2010.12.14 16.719 2,140,000... 2010.12.30 16.686 1,510,000... 2011.02.09 16.699

32.... 10,000 1,000 1... 990,000 99,000... 1,000,000 100,000 5... 19,000,000... 20,000,000 100,000... 20 2 1... 39,980 3,998 2... 7,246 725... 47,246 4,725 3... 162 16... 47,408 4,741 3... 12 1 4... 264 26 5... 906,007... 953,691 4,768 (1) 990,000,000 0.10 10,000,000 1,000,000,000 39,980,0003,998,000 (2) 7,246,376 0.10 1.382.76 (3) 162,52811,835 0.10 1.682.785.99 8.843 (4) 263,833 0.10 (5) 0.10 20 0.005 20,000,000,000 0.005 953,691,440 0.005

33. 708,695 1.38 1.00 0.4019 0.8046 570,000 1,151,000575,000 5.75% 1,151,000 708,695 32 14,173,9000.069... 1.380... 1.380... 35%... 5... 5.689%... 4%... 2 570,000

34. CMS Healthlink CMS Healthlink 32 2,221,000 32 50% 25%

... 5,707 5,707... (2,864) (2,864)... (3,998) (3,998)... 19,264 19,264... (570) 570... (1,547) (1,547)... (4,725) 4,725... 17,147 1,709 570 (7,589) 4,725 16,562... (744) (744)... (2,362) (4,725) (7,087)... (4,725) 4,725... 17,147 1,709 570 (15,420) 4,725 8,731... 25,412 25,412... 435 435... (11,503) (11,503)... (4,741) (4,725) (9,466)... (4,741) 4,741... 6,079 1,709 570 510 4,741 13,609... (1,534) (1,534)... 103 103... 2,299 2,299... (4,741) (4,741)... 8,481 1,709 570 (1,024) 9,736 CMS Healthlink CMS Healthlink 32

35. Crosspac70%Crosspac 36. 37.... 34,932 45,657 63,494 66,479... 162... 31 406... 18... (145) (131)... (12,920) (16,116) (29,771) (28,582)

... 22,365 13,623 18,482 14,312... (1,098) (182) (142) 8,960,000 10,440,00031 75.1% 70.1% 76.4% 81.7% 31(ii) 31

... 5,026 6,535 245 4,935 595 9,628 4,946 8,373... 1,266 16 2,243 316 1,719 1,524 90... 32 89 140 51 7% 7% 7% 7%... 106 328 632 237... 89 156 98 (94) 5% 558,000 635,000

1 1-5 5... 12,920 12,920 12,920 1 1-5 5... 9,252 9,252 9,252... 741 3,512 4,389 8,642 6,864 9,993 3,512 4,389 17,894 16,116 1 1-5 5... 7,125 7,125 7,125... 879 3,679 3,032 7,590 6,129... 7,682 7,682 7,557... 9,014 9,014 8,960 24,700 3,679 3,032 31,411 29,771... 95 95 71... (53) (53)... 142 142 89 89 74

1 1-5 5... 6,439 6,439 6,439... 884 3,699 2,575 7,158 5,797... 6,003 6,003 5,906... 10,520 10,520 10,440 23,846 3,699 2,575 30,120 28,582... (18) (18) (18)... (35) (35)... 70 70 35 35 131

... 162... 31 406... 145 113

38. (a) 60% 3 386,000 60%... 2... 2,968... 553... 42... (1)... (2,831)... (6)... (257)... (5)... (454) 11... (4)... 379... 386... (386)... 42 (344)

40% 263,833 0.10 (b) 100% 1.5 198,000 39(b)... 4... 2... 4... 5... (19) (4)... 202... 198... (198)... 5 (193)

39. (a) 0.1Healthlink Healthlink Healthlink 17.9%82.1 Healthlink Healthlink 17.9 Healthlink Healthlink1,969,000 82.1% Healthlink Healthlink 8,681,000 Healthlink 38,921,747 0.01 Healthlink Healthlink 1,969,000 Healthlink... 346... 91... 8,099... (185) 8,351... 330 8,681 12... 8,681... 8,099... 1,969 10,068 Healthlink 1,948,000 2,299,000 1,138,000 955,000

8,000 622,000 1,344,000 3,000 280,000 2,022,000 782,000 275,000 1,645,000 136,000 894,000 197,000 (b)... 6... 107... 1... 1... (341) (226)... 202 (24)... 24...... 1 5,000 15,00044,000 95,000 75,000 43,000 40.... 181 462 487 413... 363 631 390 202 544 1,093 877 615 1 5

41. (a) 25 * 347 191 149 131 303 743 307 395 Sunpharma GmbH 107 157 # 112 258 2,325 * # Sunpharma GmbH

(b) A i... 3,000 4,537 11,606 11,600... 1,463 4,394 4,400 3,000 6,000 16,000 16,000... 2,062 3,450 5,277 2,437... 2,062 3,450 5,277 2,437 B ii... 10,252 10,308... 2,929 2,945 13,181 13,253... 1,648 4,267... 1,648 4,267 (i) (ii) (c) 8

42. 546,000 638,000 689,000 314,000 43. (PTC) (a) (b) (c) (d) 5 (d) 0.5% 3% 451,000 104,000 162,52811,835 32

B. Treasure Sea Limited C. 499,000 D. E. UBS AG

A. (1) (2) (3) 3.60... 58,789 73,219 132,008 0.12 0.91 5.06... 58,789 104,687 163,476 0.15 1.13 (1) 64,954,000 6,165,000 (2) 170,000,0003.60 5.06 7.77 1 (3) 1,123,691,440

B. 1... 30 233 2... 2.7 20.8 1. 2. 1,123,691,440 1 7.77

C. 200,000,000 0.005 A BII-1 II-2 429 7 429(7) 300 429(1)

a) b) c) 429(1)

1. 2. (1) (2) (3) (4)

3. (a) 2 UBS AG

(b) 8 52 UBS AG

398 10 1

5 12 (HK$) 10.8747 510 21 6 ( ) MRICS MHKIS MSC(e-com) MRICS MHKIS MSC(e-com)24 17

1. 100% 15,100,000 15,100,000 7 17,260,000 17,260,000 2. 100% 1,300,000 1,300,000 14 B1 1,490,000 1,490,000 16,400,000 16,400,000 18,750,000 18,750,000 3. 100% 19,400,000 19,400,000 G14315-0115 22,180,000 22,180,000

4. 100% 510 21 6 5. 100% 11 A 68

6. 100% 1063 A 3 7. 55% 313 13 1303 8. 100% 35,800,000 35,800,000 40,930,000 40,930,000

1. 7 165 35,014.68 11,955.85 15,100,000 17,260,000 100% 15,100,000 17,260,000 1. (2009) 350 35,014.68 2. 16 1611,955.85... 624.08 2000 2 710000297... 672.49 2000 1 710000302... 2,848.88 2001 2 710000303... 26.70 1987 1 710000300... 1,789.31 1987 2 710000304... 1,331.17 2001 5 710000292

... 57.24 1990 1 710000299... 359.15 2000 1 710000290... 160.06 1997 1 710000294... 34.50 1989 1 710000295... 31.17 1989 1 710000293... 773.36 2005 2 710000289... 1,520.57 2003 1 710000288... 194.37 1987 1 710000298... 520.82 1980 2 710000291 UDCA... 1,011.98 2006 2 710000296... 11,955.85 3. 4. (a) (b)

2. 1714 1,300,000 14 B1 179.35 50 1,490,000 100% 1,300,000 1,490,000 1. 2000254492 179.35 50 2. 3. 4. (a) (b)

3. G14315-0115 36,422.4 50 19,400,000 22,180,000 100% 19,400,000 22,180,000 1. (2009) 5063 ) 36,422.4 50 19,300,500 (a) 40% (b) 2.2 (c) (d) 30% (e) 229 (f) 2. 600041299136,422.4 50 3. PS-2010-0018 80,130 76,6303,500 12 9

4. 5. (a) (b) (c)

4. 27 21 CMS 510 21 6 1,964 1,351 68,544 1. Island Communication Investments Limited 2. 3. CMS 4. (3)

5. 122 68 2,451.14 11 98,046 A 6 8 1. 4000388861 50 2. 3. 4. (a) (b) (c)

6. 83 2,383 1063 A 3 65,532.5 1. 4000340325 50 2. 3. 4. (a) (b) (c)

8. 1,477.77 1. 00042826 1,477.77 2. 3. 4. 1,477.77 3 5. 6.

7. (a) (b) (c)

1. 2219613 2. A. 100,000,000 20,000,000,000 0.005 B. (a)

(b) (c) (d) (e) (f) (i)

(ii) (iii) (iv) 5% (v) (aa) (bb) (vi) (g)

) (h) (i) (ii) (iii) 12 (iv) (v) (vi)

(vii) (i) (j) C. D. E.

(i) (ii) (iii) F. G.

H. 15 I.

21 J. 21 14 (a) (b) 95%

(a) (b) (c) (d) (e) (f) (g) 20% (g) K. (a) (b) (c) (d) (e) (f) 14

30 60 L. M. N. (a) (b)

48 4812 P. 14 15

14 15 Q. 14 30 60 2.50 R.

D. S. T. U. (i)12 (ii) (iv) (iii)12 (iv) 12

A. B. C. (a) (b) (c) 37 (d) (e) (f)

D. 34 34 C E. Foss v. Harbottle (a) (b) (c) F.

G. H. (a) (b) (c) I. J. K. L.

M. 75% N. 90% O. P. (i) (ii) Q. R. 19996 (1) (2) (i)

(ii) 19996(3) 20 S. T. Maples and Calder

A. 1. 510 21 2106 XI 510 21 2106 2. (a) 168.3 162,528 0.1 4,740,890.40 47,408,904 0.1 (b) 488.5 Archiever Development Limited263,833 0.1 40% 4,767,273.70 47,672,737 0.1 (c) 598.9 11,835 0.1 4,768,457.20 47,684,572 0.1 (d) 0.1 20 0.005 100,000,000 20,000,000,000 0.005 4,768,457.20 953,691,440 0.005

3. (a) (b) 20% (c) 15 13.36(2)(b) (d) 10% (e) (i) (ii) (A) (B) (f) 41 4. (a) 40%15,407,828 Archiever Development Limited 263,833 0.1

5. (a) (b) (c) (d) (e) 1,123,691,440 112,369,144 (x) (y)

(f) (g) (h) (i) (j) (k) 26 B. 1. (a) 1,328,888 51% (b) CMS Winpro Development Limited 22,500,000 73.47%

(c) 148,825.95 (d) CMS Synda Limited CMS 6,000,000Synda Limited 24.49%Synda Limited CMS73.47% Winpro Development Limited4,500,000 (e) CMS Synda Limited 6,000,000 24.49% (f) CMS Karl Luschmann CMS 6,000,000Karl Luschmann 24.49%Karl Luschmann CMS73.47% Winpro Development Limited4,500,000 (g) CMS Karl Luschmann 6,000,000 24.49% (h) 1,764,705 30% (i) 411,765 7% (j) 411,765 7% (k) 411,765 7% (l) (m) 15,407,828 Archiever Development Limited 263,833 0.1 (n) (o) Treasure Sea

2. 55% 7 55% 45% 3. (a) (i) 3570103 29 2004.12.07-2014.12.06 3690075 44 2005.10.14-2015.10.13 3690077 42 2006.01.14-2016.01.13 3690078 41 2005.09.07-2015.09.06 3690079 40 2005.08.14-2015.08.13 3690080 36 2006.01.07-2016.01.06 3690081 35 2005.08.14-2015.08.13 3690082 10 2005.04.21-2015.04.20 3690083 9 2005.04.21-2015.04.20 3690084 5 2005.12.28-2015.12.27 1998436 10 2002.12.07-2012.12.06 1049816 37 2007.07.07-2017.07.06 1091826 42 2007.08.28-2017.08.27 1495740 42 2000.12.21-2010.12.20

1202277 5 2008.08.28-2018.08.27 1320259 5 2009.10.07-2019.10.06 * 3134098 5 2004.02.14-2014.02.13 3513160 5 2005.01.28-2015.01.27 3570287 3 2005.06.28-2015.06.27 1196307 5 2008.08.07-2018.08.06 1200319 5 2008.08.21-2018.08.20 1200320 5 2008.08.21-2018.08.20 1200321 5 2008.08.21-2018.08.20 1200322 5 2008.08.21-2018.08.20 1202274 5 2008.08.28-2018.08.27 1202279 5 2008.08.28-2018.08.27 1236295 5 2009.01.07-2019.01.06 1236296 5 2009.01.07-2019.01.06 1236297 5 2009.01.07-2019.01.06 1242252 5 2009.01.28-2019.01.27 1246225 5 2009.02.14-2019.02.13 1246226 5 2009.02.14-2019.02.13 1295223 5 2009.07.21-2019.07.20 1320258 5 2009.10.07-2019.10.06

1320260 5 2009.10.07-2019.10.06 1365151 5 2010.02.21-2020.02.20 1468579 5 2000.11.07-2010.11.06 1468583 5 2000.11.07-2010.11.06 1496582 5 2000.12.28-2010.12.27 1521838 5 2001.02.14-2011.02.13 544158 5 2001.02.28-2011.02.27 1540517 5 2001.03.21-2011.03.20 1560469 5 2001.04.28-2011.04.27 1620448 5 2001.08.21-2011.08.20 1908461 5 2002.09.28-2012.09.27 1265204 5 2009.04.21-2019.04.20 * Dr. Falk Pharma GmbH (ii) 301542122 5 10 2010.02.10-2020.02.09 301542113 5 10 2010.02.10-2020.02.09

(b) ZL031138834.9 2003.02.25 ZL03117845.6 2003.05.09 ZL200410022741.6 2004.06.01 16 ZL02141038.0 2002.07.11 ZL200510021939.7 2005.10.20 20 (c) www.cms.net.cn... 1999.12.09 www.chinamedicalsystem.com... 2007.01.18 www.chinamedicalsystem.hk... 2008.04.17 www.chinamedicalsystem.net... 2007.01.18 www.kangzhe.net... 2008.10.04 www.kzzy.net... 2009.03.05 (d) CMSERP 2007SR17508 2002.10.30-2052.12.31

4. 0.5 2008.04.21-10 2013.04.20 250 2010.07.05-2015.07.04 0.4 2008.05.15-2013.05.14 0.006 0.040 40 50 2009.03.13-2013.03.12 0.25 2010.04.10-2015.04.09 0.5 2010.02.11-2015.02.10 0.25 2010.02.11-2015.02.10 0.5 2010.02.11-2015.02.10 604 2010.04.08-2015.04.07 0.25 2004.07.27-2009.07.26 * 0.25 2004.07.27-2009.07.26 * * C. 1. 2. 516,000 499,000

3. XV 78 352 650,000,000 57.8% 1 3,539,820 0.3% 2 14,195,820 1.3% 40,000,000 3.6% 3 3,539,820 0.3% 4 14,173,900 1.3% 5 2,930,000 0.3% 2,000,000 0.2% 6 3,539,820 0.3% 4 1,600,000 0.1% 40,000,000 7 3.6% 2,106,000 0.2% 8 3,539,820 0.3% 4 5,276,660 0.5% 9

(1) Treasure Sea (2) 4 (3) Viewell Limited (4) 3,539,820 3,539,820 (5) (6) Great Creation Holdings Limited (7) Wide Harvest Limited (8) (9) Archiever Development Limited 30,000,000 1 2 2.7% 10,000,000 1 3 0.9% (1) Treasure Sea (2) Treasure Sea (3) Treasure Sea 4. XV23 XV23 Martin Currie (Holdings) Limited 72,353,760 (L) 6.4% Martin Currie Limited 72,353,760 (L) 6.4%

Martin Currie Inc. 72,353,760 (L) 6.4% China Fund, Inc. 72,353,760 (L) 6.4% : China Fund, Inc. Martin Currie Inc. Martin Currie Limited Martin Currie Limited Martin Currie (Holdings) Limited 72,353,760 5. (a) XV78 352 (b) D. 1. (c) (d) XV23 10% (e) D. 1.

D. 1. UBS AG Maples and Calder UBS AG Maples and Calder 1 4 6 79 2. 44A 44B 3. (a) (b) (c) 4. 32L 4 5. Treasure Sea Treasure Sea ATC Trustees (BVI) Limited 2/F Abbott Building, Road Town, Tortola, British Virgin IslandsTreasure Sea

D. 1. B.1. 14510 21 2106 (a) (b) (c) (d) (e) (f) (g) Maples and Calder (h) (i) D. 1. (j) B.1. (k)

(1)... (2) (3)... (4)... elpo (5) (www.cms.net.cn) (www.hkex.com.hk)... (6)...