是為父母提供全面育兒解決方案 1

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FCS, FCIS Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY1-1111 Cayman Islands 5 29 510623 200 35 3508 www.biostime.com.cn 1 6

1 22 15 43 Royal Bank of Canada Trust Company (Cayman) Limited 4th Floor, Royal Bank House 24 Shedden Road, George Town Grand Cayman KY1-1110 Cayman Islands 183 17 1712-1716 7

4,731,563 4,561,299 2,926,931 2,975,120 806,786 820,715 972,172 660,473 1.34 1.37 1.31 1.34 84.1% 9.0% 3.2% 3.7% 82.3% 10.0% 4.4% 3.3% 100 +12.4% 2,000,000 1,958,149 +44.8% 1,741,693 1,500,000 1,203,234 1,000,000 500,000 0 8

3.7%17.1%4,731.6806.8 100 VIPO2OO2O 10.1% 100100 1.910085,000 20,000O2O4,000O2O 9

O2OB2C B2C B2C O2O B2C 11.4% 6.1% 17.9% 3.7% (1) 100 (1) 10

14.4% 10010012.4% 1,958,14964.7% 34,098100 76.8%25,000 60% VIP 24,615VIP2,8246,659 76.4% 152.8% 27.2% 17631 11

BINC BINC BINC BINC Mérieux NutriSciences Isigny Sainte Mère ISM ISM CNCA AQSIQ 3,200 2,103,316 12

O2O VIP30,000VIP 6,000 10% 13

100 O2O100 100 O2O Mana100 International Holding LimitedO2O B2CB2C C2C C2C 30% 14

0.41 0.26 0.6740.0% 0.115.0 510 330 15.0 15

100 16

4,731,563 4,561,299 2,926,931 2,975,120 1,587,764 1,513,046 175,268 177,313 806,786 820,715 972,172 660,473 (460,394) (80,749) 1,171,847 (214,674) 4,493,340 2,517,710 3.7%4,731.6 3,981,575 84.1% 3,752,116 82.3% 425,094 9.0% 458,164 10.0% 151,420 3.2% 198,778 4.4% 173,474 3.7% 152,241 3.3% 4,731,563 100.0% 4,561,299 100.0% 17

6.1%3,981.6 17.9% 14.2% 10.5%63.0%60.5% 2.537.0% 458.27.2%425.1 9.0% 3.9% 3.2% 23.8% 151.4DHA 152.213.9%173.5 100 2,926.91.6% 65.2%61.9%(i) (ii) (iii) 18

20.4%128.1 113.1 10.6 0.433.2%33.6% 1,513.04.9%1,587.8 (i)(ii) 177.31.1%175.3 3.9%3.7% 87.5 49.78.2 86.78.7 78.0 341.38.7%311.6 29.4%27.9% 162.9 19

972.2 1,310.6338.4 1,159.6 151.0 460.4 (i)148.4(ii) 40.0 40.0(iii)48.8 (iv)293.377.5 31.1 1,171.8 2,414.4 492.7 750.6 3,347.2 1,146.2 4,493.3 3,100,000,000 90.84 2,410.5 36.4% 20

535,693 445,516 156,031 375,522 2,491 2,881 102,812 147,974 797,027 971,893 i)ii) iii)aqsiq (2) CIQ (1) 100112 1 170176 29231 7165 (1) (2) 21

1,595.6 : 558.5 558.5 319.1 319.1 239.3 239.3 239.3 239.3 79.8 47.5 32.3 159.6 159.6 1,595.6 1,563.3 32.3 22

A.2.1 23

4153 24

25

6 A.2.1 4153 3.29 26

14 7 13 27

1 13/13 1/1 3/3 1/1 13/13 1/1 13/13 1/1 13/13 1/1 13/13 2/2 1/1 12/13 1/1 2 13/13 2/2 1/1 3/3 1/1 3 13/13 2/2 1/1 3/3 1/1 13/13 1/1 09/01/2014 24/03/2014 25/03/2014 18/04/2014 08/05/2014 14/01/2014 18/08/2014 24/06/2014 25/03/2014 09/10/2014 22/04/2014 26/06/2014 14/07/2014 05/08/2014 19/08/2014 04/09/2014 16/09/2014 09/10/2014 06/11/2014 31/12/2014 1 2 3 28

3.13 3.13 61 www.biostime.com.cn 29

500,0011,000,000 3 2,000,0013,000,000 4 3,000,0014,000,000 1 4,000,0015,000,000 6 5,000,0016,000,000 2 6,000,0017,000,000 1 7,000,0018,000,000 1 9 30

B B B B B B A, B A, B B A B 31

D.3.1 (a) (b)(c) (d)(e) 84 32

84(1) 84(2) 33

34

85 86 2,900 146 3,046 35

36

100100 37

66 25 700 5 38

100 O2O 281 39

(www.biostime.com.cn) IR@biostime.com.cn 58 20035 3508 20035 3508 40

51 Biostime International Investment Limited Biostime Investment Biostime Hong Kong Limited Biostime Hong Kong Parenting Power International Holdings Limited Parenting Power Holdings Parenting Power Investment Limited Parenting Power Investment Parenting Power Hong Kong Limited Parenting Power Hong Kong Mama100 International Holdings Limited Mama100 Holdings Mama100 International Investment Limited Mama100 Investment Mama100 Hong Kong Limited Mama100 Hong Kong XV2369 20 53 XV2318 41

50 XV23 Stoltze Specialty Processing, LLC 18 (University of Nebraska-Lincoln) Xoma (US) LLC (Osaka University) (University of Nebraska-Lincoln) 59 XV23 42

54 Biostime Investment Biostime Hong Kong Parenting Power Holdings Parenting Power Investment Parenting Power Hong Kong Mama100 Holdings Mama100 Investment Mama100 Hong Kong XV23 69 100 51 Biostime Investment Biostime Hong Kong Parenting Power Holdings Parenting Power Investment Parenting Power Hong Kong Mama100 Holdings Mama100 Investment Mama100 Hong Kong XV23 43

53 SW Corporate Services Group Limited 20 ) ) BaWang International (Group) Holding Limited 1338 Bosideng International Holdings Limited 3998 China Coal Energy Company Limited 1898 Juda International Holdings Limited 1329 LDK Solar Co., Ltd. OTC Pink Limited Information LDKYQ Powerlong Real Estate Holdings Limited 1238 Sany Heavy Equipment International Holdings Company Limited 631 SITC International Holdings Company Limited 1308 China Railway Group Limited 390 Yangtze Optical Fibre and Cable Joint Stock Limited Company 6869 44

59 1368 178884 Rene Sola Ltd SOL 109930 7 Days Group Holdings Limited7 Days Group Holdings Limited 7 Days Group Holdings LimitedAFE Computer Services Limited Infocast Pty Limited 45

67 46100 46

39 10 Patrice Malard61 Biostime Pharma Patrice 30 Gist Brocades SA CPIAA SAPioneer Hi-Bred Silab Sarl Lallemand SAS Kloarys Developpement Sarl 47

40100 100 10ERPCRM Laetitia Garnier34 Banque Populaire Group LVMH Group 37 48

38 40 37 10 49

43 Parenting Power 42 42 50

37BMcare BMcareBMcare 36Adimil Adimil 43 51

39 Snickers 31 31 58 25 52

8.17 8.17 3.28 13.51B(1) 6869 1099 13.51B(1) 53

21 21 8792 0.26 0.41 0.41 12 (a) 18317 1712-1716 54

(b) 18317 1712-1716 14 3,100.0 2,4414.4 31 34 37 22 3 4,746.3 196.9 37 55

0.1 2.73.86.6 175176 30% Arla Foods amba Arla FoodsArla Foods Arla Foods Arla Foods429.4 27.3%1,241.878.9% 56

84(1) 84(2) 5% 9 57

4153 3.133.13 XV352 6 621,2391 0.102% 194,1002 0.032% 450,000,0003 74.156% 450,000,0003 74.156% 381,5581 0.063% 99,0004 0.016% 100,0005 0.016% 100,0005 0.016% 100,0005 0.016% 58

1 2 97,000 55,00030,500 11,600 3 Coliving Limited47.71% Coliving Limited Coliving LimitedFlying Company Limited59.00% Sailing Group Limited41.00%Coliving Limited Flying Company Limited Sailing Group Limited UBS Trustees (BVI) Limited UBS Nominees LimitedFlying Company Limited Sailing Group Limited 4 46,000 29,000 18,000 6,000 5 6 606,825,765 352 59

30% 10% 1% a) 0.1%b5 281 60

(i) (ii)(iii) 16/12/2011 12.12 100,000 100,000 16/12/2011 12.12 100,000 100,000 16/12/2011 12.12 100,000 100,000 300,000 300,000 09/06/2011 15.312 704,918 (108,302) (1) (64,661) 531,955 29/11/2011 11.52 747,795 (120,738) (2) (83,463) 543,594 01/06/2012 19.64 582,579 (60,197) (3) (76,852) 445,530 07/12/2012 24.70 1,183,361 (104,979) (4) (160,641) 917,741 3,518,653 (394,216) (385,617) 2,738,820 1 47.34 2 42.86 3 46.94 4 48.59 61

30% 30% 40% (a) 2.53 (b) 11,150,249 (c) 30% 30% 40% (d) 6 62

32911,150,249 3141.00 15 215,615 621,239 621,239 381,558 381,558 1,002,797 1,002,797 2,655,665 (748,343) (1) 1,907,322 5,420,261 (1,285,890) (2) (215,615) 3,918,756 100,000 100,000 8,175,926 (2,034,233) (215,615) 5,926,078 9,178,723 (2,034,233) (215,615) 6,928,875 1 50.80 2 47.96 63

10% 5% 1% 198662,427 64

1,239,8871 0.206% (1,086,666) (153,221) 817,3942 0.136% (817,394) 662,4273 0.110% (16,827) 645,600 2,719,708 0.452% (1,086,666) (987,442) 645,600 1 30,50018,000 2 15,5009,500 3 11,6006,000 36 65

(a) (b) 40 66

1.5% 1% 1% 8861,265,644 1,0182,103,316 (i)1,265,644 (ii) 837,672 67

1,265,644 0.210% (1,265,644) 2,103,316 0.349% (105,031) 1,998,285 3,368,960 0.559% (1,370,675) 1,998,285 68

XV23 336 2 1 450,000,000 74.156% Flying Company Limited1 450,000,000 74.156% Sailing Group Limited1 450,000,000 74.156% Coliving Limited1 450,000,000 74.156% UBS Trustees (BVI) Limited1 450,000,000 74.156% 1 Coliving Limited47.71% Coliving Limited Coliving LimitedFlying Company Limited59.00% Sailing Group Limited41.00%Coliving Limited Flying Company Limited Sailing Group Limited UBS Trustees (BVI) Limited UBS Nominees LimitedFlying Company Limited Sailing Group Limited 2 606,825,765 XV23 336 69

8.10 A 52.8% 27.2% 20% 30% 14A.07(4)14A.12(1) 70

10,000,00015,000,000 140.1% 5% 14A 10,000,00057.7%26% 11.9%4.4% 50% 71

(i) (i)(ii) (ii) (iii) (i) (ii) O2O 72

O2O (i) O2O (ii) O2O (i) (ii) (iii) (iv) (v) (vi) 73

(1) 90% 100% 90%10% (2) (3) 10,000 1% 74

(4) (i) (ii) (iii) (5) (i) (ii) (iii) 75

(5) (i) (ii) (iii) (iv) (v) (i) (ii) 76

(6) 2% 10% 100% 1 57.7% 26.0% 11.9% 4.4% 1. 77

120,000 78

(i)(ii) (i) (ii) 79

(i) 120,000 (ii) 3,000 (iii) 5% (i)(ii) (iii) (i) 1,000,000 80

2014 2015 2016 5,730,000 7,800,000 10,060,000 5,220,000 6,900,000 8,520,000 510,000 900,000 1,540,000 19,300,000 32,910,000 62,210,000 1 1,000,000 26,030,000 40,710,000 72,270,000 1. 81

57.7% 26% 11.9% 4.4% 14A(i) (ii) 14A.81 0.1%5% 14A.76(2) 14A (i)(ii)(iii) 3000 740 14A.38 82

10,000,000 6,376,888 5,220,000 510,000 19,300,000 5,866,185 1,000,000 1,000,000 83

25% 48 2340 84

87174 85

1 22 86

5 4,731,563 4,561,299 (1,804,632) (1,586,179) 2,926,931 2,975,120 5 128,065 106,397 (1,587,764) (1,513,046) (175,268) (177,313) (87,548) (55,573) 6 (86,673) (10,589) 22 592 7 (162,900) 8 1,118,335 1,162,096 10 (311,549) (341,381) 806,786 820,715 (5,581) (823) 801,205 819,892 11 806,786 820,715 801,205 819,892 13 1.34 1.37 1.31 1.34 12 87

14 478,032 326,187 15 63,243 64,721 16 76,000 76,000 17 104,110 109,889 18 130,302 98,092 19 53,531 85,497 20 15,741 14,755 22 40,592 22 40,000 23 18,810 21,240 27 1,146,183 854,874 32 128,896 123,892 2,295,440 1,775,147 24 797,027 971,893 25 12,043 15,182 26 137,467 110,935 42 2,000 19 39,457 27,090 19 2,570 5,936 27 70,000 27 3,347,157 1,662,836 4,335,721 2,865,872 28 294,542 361,634 29 737,494 719,838 30 750,613 235,588 212,725 1,267,624 2,044,810 3,068,097 821,062 5,363,537 2,596,209 88

5,363,537 2,596,209 31 2,410,526 32 35,924 80,616 2,446,450 80,616 2,917,087 2,515,593 34 5,197 5,161 31 66,978 37(a) 2,647,968 2,143,222 12 196,944 367,210 2,917,087 2,515,593 89

5,161 390,649 (30,505) 26,992 95 167,307 16,716 22,985 (58,920) 1,368,215 413,957 2,322,652 820,715 820,715 (823) (823) (823) 820,715 819,892 137,217 (137,217) 35 10,075 10,075 36 (64,093) (64,093) 36 27,431 12,250 9,296 48,977 12 1,036 # (189,933) (188,897) 12 1,221 # (224,024) (222,803) 12 (119,437) (119,437) 12 (90,773) (90,773) 12 (209,834) 209,834 12 (157,376) 157,376 5,161 182,696 (67,167) 26,992 95 304,524 26,791 35,235 (59,743) 1,693,799 367,210 2,515,593 806,786 806,786 (5,581) (5,581) (5,581) 806,786 801,205 42,100 (42,100) 35 19 15,325 (1,373) 13,971 36 17 25,026 (24,373) 11,374 12,044 31 66,978 66,978 12 (674) # (209,834) (210,508) 12 (505) # (157,376) (157,881) 12 (124,315) (124,315) 12 (196,944) 196,944 5,197 198,021* 66,978 (42,141)* 26,992* 95* 346,624* 25,418* 10,862* (65,324)* 2,147,421* 196,944 2,917,087 * 2,647,968,000 2,143,222,000 # 90

1,118,335 1,162,096 5 (105,034) (82,932) 5 (8,085) (4,654) 6 86,673 10,589 22 (592) 8 41,879 25,665 8 7,310 480 8 1,478 419 8 97 36 8 984 3,707 8 4,488 10,075 8 12,044 48,977 1,159,577 1,174,458 173,882 (452,333) 3,139 (14,810) 13,340 (795) (67,093) 98,516 25,998 205,226 2,000 (2,000) (289) (321) 1,310,554 1,007,941 (338,382) (347,468) 972,172 660,473 91

972,172 660,473 (134,597) (135,700) 1,678 122 (13,824) (2,230) 38 (350,000) 23 (21,240) (48,847) (98,092) 22 (40,000) 31,050 9,212 77,455 59,540 22 (40,000) 27 (2,000) 370,451 27 (291,309) 87,188 (460,394) (80,749) 2,414,370 35 9,483 (64,093) 645,186 (750,613) (165,099) (8,690) (8,758) (492,703) (621,910) 1,171,847 (214,674) 1,683,625 365,050 764,836 400,615 (1,304) (829) 2,447,157 764,836 27 2,447,157 764,836 92

14 8 5 19 53,531 85,497 21 3,790,750 3,763,629 32 335 334 3,844,624 3,849,465 26 31,393 26,989 21 1,456,603 567,783 21 1,117,106 19 39,457 27,090 19 2,570 5,936 27 477,303 174,253 3,124,432 802,051 28 30,567 39,511 21 52,294 26,878 29 13,561 7,231 1,398 1,393 30 750,613 97,820 825,626 3,026,612 (23,575) 6,871,236 3,825,890 31 2,410,526 4,460,710 3,825,890 34 5,197 5,161 31 66,978 37(b) 4,191,591 3,453,519 12 196,944 367,210 4,460,710 3,825,890 93

1. Cricket Square, Hutchins Drive, P.O. Box 2681, Grand Cayman KY1-1111, Cayman Islands 50% (i) (ii) (iii) (iv) 10,0001% (v) 94

1. 2.1 32 (i)(ii) (iii)(i)(ii) (iii) 95

2.2 10 12 27 32 39 21 2 3 13 1 1 1 1 2.3 9 4 10 28 10 12 28 2 2 11 2 14 5 15 3 1 2 16 2 38 96

2.3 16 2 41 19 1 27 2 1 1 2 1 2 3 4 5 622 9 399 99 102810 28 11 3 11 97

2.3 15 15 15 15 16381638 2.2 88 98

2.4 (a) (b) (c) 5 20% 99

2.4 39 39 100

2.4 101

2.4 102

2.4 (a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) (vi) (a) (vii) (a)(i) 5 103

2.4 9% 18% 18% 30% 18% 20% 5 18 104

2.4 105

2.4 39 39 106

2.4 (a) (b) 107

2.4 108

2.4 109

2.4 110

2.4 111

2.4 (a) (b) (c) 35 36 112

2.4 113

2.4 114

2.4 3. 115

3. 55,715,000 16 116

3. 5,953,000 4,969,000 797,027,000 971,893,000 4. (a) (b) (c) DHA (d) 117

4. 10% 3,981,575 425,094 151,420 173,474 4,731,563 2,466,913 303,707 74,345 81,966 2,926,931 113,119 14,946 (1,849,988) (86,673) 1,118,335 2,679 1,540 623 85 45,740 50,667 781 210 (93) 86 984 * 44,306 530-36 152,217 197,089 118

4. 3,752,116 458,164 198,778 152,241 4,561,299 2,421,955 360,182 110,530 82,453 2,975,120 87,586 18,811 (1,908,832) (10,589) 1,162,096 823 2,039 893 160 22,649 26,564 3,430 35 431 (189) 3,707 * 294,945 # 3,978 321 42 130,914 430,200 # * # 38 119

5. 4,731,563 4,561,299 105,034 82,932 8,085 4,654 14,021 1,239 1,193 10,581 1,218 3,126 2,379 128,065 106,397 6. 8,690 10,589 77,983 86,673 10,589 120

7. 162.9 6% 8. 1,803,648 1,582,472 14 41,879 25,665 17 7,310 480 15 1,478 419 2,900 2,730 * 49,724 43,725 55,255 38,371 97 36 9(a) : 558,308 671,031 109,087 78,797 31,926 31,783 35 4,488 10,075 36 12,044 48,977 715,853 840,663 8,187 (14,021) # 984 3,707 * # 121

9. (a) 622 1178 32 161 1,780 1,780 4,123 3,007 9,445 10,266 288 457 411 2,017 134 124 14,401 15,871 16,181 17,651 35 36 122

9. (a) 200 2,740 6,311 178 261 67 9,757 200 1,383 3,134 110 150 67 5,044 400 4,123 9,445 288 411 134 14,801 120 120 120 120 120 120 120 120 480 480 300 300 300 300 300 300 900 900 1,780 4,123 9,445 288 411 134 16,181 123

9. (a) 200 2,076 5,685 283 1,284 62 9,590 200 931 4,581 174 733 62 6,681 400 3,007 10,266 457 2,017 124 16,271 120 120 120 120 120 120 120 120 480 480 300 300 300 300 300 300 900 900 1,780 3,007 10,266 457 2,017 124 17,651 124

9. (b) 9(a) 1 4,037 2,569 10,328 13,722 257 409 681 2,070 200 185 15,503 18,955 5,000,0015,500,000 1 6,500,0017,000,000 1 7,000,0017,500,000 1 7,500,0018,000,000 1 1 9,000,0019,500,000 1 3 3 35 36 125

10. 355,130 395,819 5,759 8,401 356 183 32 (49,696) (63,022) 311,549 341,381 16.5% 25% 33.3% 126

10. 1,118,335 1,162,096 279,584 290,524 2,357 (3,902) 18,280 57,940 (5,194) (1,049) 2,370 5,313 5%5% 14,152 30,569 5% (38,014) 311,549 341,381 11. 1,026,854,000 479,710,00037(b) 12. 0.260.25 124,315 119,437 0.19-90,773 0.410.44 196,944 209,834 0.33 157,376 321,259 577,420 127

13. 602,326,189599,639,595 806,786 820,715 604,420,682 602,294,000 (2,094,493) (2,654,405) 602,326,189 599,639,595 11,632,885 13,480,561 613,959,074 613,120,156 128

14. 89,337 64,325 85,379 33,889 14,461 113,039 400,430 14 6,616 16,730 14,916 286 156,996 195,558 (11) (1,274) (1,876) (3,161) 1,322 (1,322) (83) (21) (104) 89,351 72,169 100,814 46,929 14,747 268,713 592,723 8,786 36,988 16,333 12,136 74,243 4,960 7,177 21,051 6,875 1,816 41,879 (5) (1,117) (264) (1,386) (33) (12) (45) 4,960 15,925 56,910 22,944 13,952 114,691 84,391 56,244 43,904 23,985 795 268,713 478,032 129

14. 17,998 57,060 30,986 14,018 6,554 126,616 256 19,581 3,049 446 106,485 129,817 38 89,337 46,076 9,700 145,113 (14) (964) (146) (1,124) 9 2 (3) 8 89,337 64,325 85,379 33,889 14,461 113,039 400,430 6,814 22,958 10,945 8,825 49,542 1,980 14,852 5,519 3,314 25,665 (12) (823) (131) (966) 4 1 (3) 2 8,786 36,988 16,333 12,136 74,243 89,337 55,539 48,391 17,556 2,325 113,039 326,187 130

14. 86 86 6 6 86 6 92 81 81 2 1 3 83 1 84 3 5 8 89 89 (3) (3) 86 86 82 82 2 2 (3) (3) 81 81 5 5 131

15. 66,199 20,566 38 46,052 8 (1,478) (419) 64,721 66,199 26 (1,478) (1,478) 63,243 64,721 16. 76,000 38 76,000 76,000 76,000 76,000 76,000 132

16. 13.93% 3% 133

17. 7,572 103,780 111,352 1,531 1,531 9,103 103,780 112,883 1,463 1,463 1,544 5,766 7,310 3,007 5,766 8,773 6,096 98,014 104,110 2,134 2,134 5,438 5,438 38 103,780 103,780 7,572 103,780 111,352 983 983 480 480 1,463 1,463 6,109 103,780 109,889 134

18. 130,302 98,092 Isigny Sainte Mère ISMISM 17,477,0751 17,477,075 11,651,384 5 10 19. 39,457 27,090 53,531 85,497 92,988 112,587 2,570 5,936 3.00% 32,654 33,863 +1% 60,334 78,724 92,988 112,587 135

19. 49% 2,570,000 5.936,000 20. 9,809 9,112 5,932 5,643 15,741 14,755 21. 3,660,325 3,648,075 130,425 115,554 3,790,750 3,763,629 1,117,106 3% 3.5% 1,456,603,000 567,783,000 52,294,000 26,878,000 136

21. * 73,010,000 100% * 34,100,000 100% * 1,000,000 100% Biostime Pharma 10,000 100% * 2,000,000 100% Biostime International Investment Limited Biostime Investment 814,999 100% Biostime Hong Kong Limited Biostime HK 126,534,300 100% Parenting Power International Holdings Limited ( Parenting Power Holdings ) 0.01 100% 137

21. Parenting Power Investment Limited ( Parenting Power Investment ) 1 100% Parenting Power Hong Kong Limited ( Parenting Power HK ) 1 100% Mama100 International Holdings Limited ( Mama100 Holdings ) 0.01 100% 100 Mama100 International Investment Limited ( Mama100 Investment ) 1 100% Mama100 Hong Kong Limited ( Mama100 HK ) 1 100% 211,165,206 100% * 1,499,990 100% Biostime Europe Holdings S.àr.l. ( Biostime Europe ) 1 100% Biostime Luxebourg S.àr.l. ( Biostime Luxebourg ) 1 100% ** 2,000,000 100% 138

21. * ** 38 22. 40,000 592 40,592 40,000 3% 28 1 40 139

22. 592 592 40,592 23. ISM 18,810 21,240 ISMBiostime PharmaISM 504,5855ISM 20% Biostime Pharma ISM ISMISM ISM ISM Biostime PharmaISMISM Biostime Pharma ISM Biostime Pharma Biostime Pharma ISM10% 140

23. ISM 2ISM Biostime Pharma15 (i) 15 (ii)biostime PharmaISM ISM 15Biostime Pharma ISMBiostime PharmaISM 24. 535,693 445,516 156,031 375,522 2,491 2,881 102,812 147,974 797,027 971,893 25. 1,529 475 10,514 14,707 12,043 15,182 141

25. 1,513 7,605 10,529 7,576 1 1 12,043 15,182 10,514,000 14,707,000 26. 31,172 26,538 27,736 23,689 1,202 1,867 166 115 87,330 77,577 3,491 3,185 16,285 3,475 15 1,478 1,478 137,467 110,935 31,393 26,989 142

27. 1,868,280 824,836 477,303 174,253 2,625,060 1,762,874-4,493,340 2,587,710 477,303 174,253 (1,146,183) (854,874) (70,000) 3,347,157 1,662,836 477,303 174,253 (900,000) (898,000) 2,447,157 764,836 477,303 174,253 3,598,252 2,382,215 48,543 5,307 895,088 205,495 428,760 168,946 4,493,340 2,587,710 477,303 174,253 143

27. 28. 289,529 354,760 30,567 39,511 5,013 6,874 294,542 361,634 30,567 39,511 273,967 356,646 30,567 39,511 19,825 4,731 750 257 294,542 361,634 30,567 39,511 30 90 20,498,000 144

29. 11,725 10,824 87,900 126,773 1,214 1,866 402,252 323,624 12,347 5,365 114,187 127,130 33 31,397 51,768 90,033 79,719 737,494 719,838 13,561 7,231 30. (%) (%) +2.25% 568,941 2.87% 35,380 1.24% 146,292 750,613 546,430,000204,183,000 145

31. 3,100,000,000 90.84 (i)3020 130%)(ii) 90% 115.34% 146

31. 2,460,625 (66,978) (46,255) 2,347,392 77,983 (14,849) 2,410,526 32. 1,266 89,108 20,576 12,942 123,892 261 3,950 5,885 (5,092) 5,004 1,527 93,058 26,461 7,850 128,896 324 56,370 13,649 8,345 78,688 942 32,738 6,927 4,597 45,204 1,266 89,108 20,576 12,942 123,892 147

32. 334 1 335 334 334 59,671 20,945 80,616 (43,366) # (1,326) 44,692 (16,305) 19,619 35,924 77,489 77,489 (17,818) # 20,945 3,127 59,671 20,945 80,616 # 14,152,00030,569,000 57,518,000 48,387,000 148

32. 128,896 123,892 (35,924) (80,616) 92,972 43,276 10% 5% 55,715,000 27,167,0001,114,300,000 543,340,000 33. 51,768 33,381 416,114 555,907 (436,485) (537,520) 31,397 51,768 149

34. 10,000,000,000 10,000,000,000 0.01 100,000,000 100,000,000 606,825,765 602,294,000 0.01 6,068,158 6,022,940 5,197,000 5,161,000 602,294,000 6,023 5,161 (a) 2,428,449 24 19 (b) 2,103,316 21 17 4,531,765 45 36 606,825,765 6,068 5,197 a (b) 2,428,449 2,428,449 0.01 24,00019,000 2,103,3160.01 21,00017,000 35 36 150

35. (a) 2.53 (b) 11,150,249 (c) 30% 30% 40% (d) 151

35. 329 11,150,249 1.00 25,068,000 (%) 0.00 0.00 0.00 (%) 57.06 57.06 57.06 (%) 1.77 1.77 1.77 4.81 5.31 5.81 2.53 9,179 2.53 9,951 2.53 (216) 2.53 (772) 2.53 (2,034) 2.53 2.53 6,929 2.53 9,179 49.00 152

35. 655 2.53 2,689 2.53 3,585 2.53 6,929 2,236,000 3,360,000 2,034,2332,034,233 20,00016,0005,126,000 4,061,000 4,040,000 6,929,00069,00055,00017,461,000 13,774,000 6,920,000 1.1% 153

35. 30% 10% 1% a)0.1%b 5.0 281 154

35. (i) (ii)(iii) 18.11 3,518 17.95 4,059 19.26 (385) 16.64 (541) 17.31 (394) 18.11 2,739 18.11 3,518 46.24 155

35. 84 211 15.312 79 224 11.52 90 90 12.12 92 175 19.64 202 355 24.70 192 211 15.312 199 224 11.52 90 90 12.12 152 175 19.64 307 355 24.70 256 283 15.312 266 299 11.52 120 120 12.12 201 233 19.64 409 473 24.70 2,739 3,518 * 2,252,000 6,715,000 ) 394,216394,216 4,000 3,0006,821,0005,403,000 1,821,000 2,739,000 27,00022,00049,435,000 38,997,000 2,698,000 0.4% 156

36. 10% 5% 1% 64,093,000 1,180,387 38,803,000 (1,086,666) (93,721) 817,394 40,252,000 (817,394) 662,427 12,783,000 (16,827) 645,600 1 2,660,208 91,838,000 (1,086,666) (927,942) 645,600 1 : 17,600 157

36. 3,834,000 48,977,000 25,043,0001,086,666 27,431,00011,374,000 9,296,000 745,933 567,526 40 158

36. 1,265,644 50,658,000 (1,265,644) 2,103,316 40,588,000 (105,031) 1,998,285 3,368,960 91,246,000 (1,370,675) 1,998,285 2,103,3160.01 21,00017,000 8,210,000 37. 2,103,316 (a) 90 1% 10% 50% 25% 159

37. (b) 390,649 (30,505) 3,260,270 16,716 22,985 (243,693) 253,513 3,669,935 (115,922) 479,710 363,788 35 10,075 10,075 36 (64,093) (64,093) 36 27,431 12,250 9,296 48,977 1,036 # 1,036 1,221 # 1,221 12 (119,437) (119,437) 12 (90,773) (90,773) 12 (209,834) (209,834) 12 (157,376) (157,376) 182,696 (67,167) 3,260,270 26,791 35,235 (359,615) 375,309 3,453,519 7,677 1,026,854 1,034,531 35 15,325 (1,373) 13,952 36 25,026 - (24,373) 11,374 12,027 (674) # (674) (505) # (505) 12 (124,315) (124,315) 12 (196,944) (196,944) 12 198,021 (42,141) 3,260,270 25,418 10,862 (351,938) 1,091,099 4,191,591 # 160

37. (b) 38. 2.4 100% 350,000,000 14 140,948 145,113 15 66,052 46,052 17 103,780 32 (20,945) 207,000 274,000 16 143,000 76,000 350,000 350,000 161

38. 4,165 (19,540) (67,000) 103,780 21,405 (460) 20,945 20,945 39. 162

40. 29,448 49,771 578 350 21,864 43,143 1,004 4,043 5,227 55,355 98,141 1,582 350 41. 40 825 333 24,206 112,089 25,031 112,422 163

42. 622 11 7832 161B 1,154 1,154 520 520 238 238 88 88 2,000 2,000 43. (a) (i) 6,377 5,630 (ii) 25,498 (iii) 40,000 164

43. (a) (i) (ii) (iii) 14A 3%2 (b) (i) (ii) (iii) (iv) 1,645,000 254,000 28 22 42 (c) 9(a) 51,202 56,294 1,016 873 731 1,169 2,459 6,719 55,408 65,055 165

44. 18 130,302 130,302 19 92,988 92,988 23 18,810 18,810 27 1,146,183 1,146,183 25 12,043 12,043 88,532 88,532 19 2,570 2,570 27 3,347,157 3,347,157 18,810 2,570 4,817,205 4,838,585 18 98,092 98,092 19 112,587 112,587 23 21,240 21,240 27 854,874 854,874 25 15,182 15,182 79,444 79,444 42 2,000 2,000 19 5,936 5,936 27 70,000 70,000 27 1,662,836 1,662,836 21,240 5,936 2,895,015 2,922,191 166

44. 19 92,988 92,988 21 1,117,106 1,117,106 21 1,456,603 1,456,603 3,657 3,657 19 2,570 2,570 27 477,303 477,303 2,570 3,147,657 3,150,227 19 112,587 112,587 21 567,783 567,783 3,300 3,300 19 5,936 5,936 27 174,253 174,253 5,936 857,923 863,859 167

44. 28 294,542 361,634 488,482 399,935 30 750,613 783,024 1,512,182 28 30,567 39,511 21 52,294 26,878 12,347 5,365 30 750,613 31 2,410,526 2,505,734 822,367 168

45. 2,570 5,936 2,570 5,936 (a) (b) 169

45. 12.0% 14.0% 1% 445,000 1% 1,194,000 31.9% 33.9% 1% 31,000 1% 65,000 170

45. 2,570 2,570 5,936 5,936 46. 2.4 171

46. 50 1,116 465 (50) (1,116) (465) 50 (2,835) (3,326) (50) 2,835 3,326 83.8% 89.2% 172

46. % 5 22,591 (436) (5) (22,591) 436 5 3,584 (7,004) (5) (3,584) 7,004 5 (90,529) (29,818) (5) 90,529 29,818 5 2,988 3,950 (5) (2,988) (3,950) 2,410,526,000 12 173

46. 3,714,074 2,125,426 6,631,161 4,641,019 56% 46% 47. 38 48. 49. 174

1,233,560 2,189,034 3,381,901 4,561,299 4,731,563 877,173 1,456,127 2,228,946 2,975,120 2,926,931 334,063 713,907 1,050,573 1,162,096 1,118,335 (68,380) (186,556) (307,467) (341,381) (311,549) 265,683 527,351 743,106 820,715 806,786 265,683 527,351 743,106 820,715 806,786 265,683 527,351 743,106 820,715 806,786 0.58 0.88 1.24 1.37 1.34 0.58 0.86 1.22 1.34 1.31 175

39,857 287,701 1,242,401 1,775,147 2,295,440 1,862,142 2,150,365 2,290,991 2,865,872 4,335,721 (236,347) (415,054) (1,133,251) (2,044,810) (1,267,624) (5,760) (45,452) (77,489) (80,616) (2,446,450) 1,659,892 1,977,560 2,322,652 2,515,593 2,917,087 1,659,892 1,977,560 2,322,652 2,515,593 2,917,087 1,659,892 1,977,560 2,322,652 2,515,593 2,917,087 176