李 氏 大 藥 廠 控 股 有 限 公 司 * 李 氏 大 藥 廠 控 股 有 限 公 司 年 報 2015 Annual Report 2015 * Annual Report 2015 年 報
目 錄 2 3 5 7 8 11 24 28 48 55 57 58 59 61 63 65
二零一五年年報 2 公司資料 Marco Maria Brughera P.O. Box 309 GT, Ugland House South Church Street, George Town Grand Cayman, Cayman Islands 2 110-111 183 17 1712-1716 www.leespharm.com 950
3 李氏大藥廠控股有限公司 公司簡介 950
二零一五年年報 4 公司簡介 * * * * * Aloxi UNIDROX *
5 李氏大藥廠控股有限公司 財務概要 922,150 955,208 3.5% 229,052 192,830 +18.8% 1,467,438 934,341 +57.1% 39.77 35.52 +12.0% 39.29 34.47 +14.0% 3.0 2.7 7.4 6.6 10.4 9.3 +11.8% 26.2% 26.2%
二零一五年年報 6 財務概要 1,200,000 1,000,000 955,208 922,150 250,000 200,000 192,830 229,052 800,000 600,000 400,000 399,685 534,333 696,953 150,000 100,000 83,906 113,807 150,467 200,000 50,000 0 2011 2012 2013 2014 2015 0 2011 2012 2013 2014 2015 1,600,000 1,400,000 1,467,438 40 35 35.52 39.77 1,200,000 30 28.41 1,000,000 800,000 786,005 934,341 25 20 17.9 22.82 600,000 582,156 15 400,000 311,914 10 200,000 5 0 2011 2012 2013 2014 2015 0 2011 2012 2013 2014 2015
7 李氏大藥廠控股有限公司 五年財務摘要 922,150 955,208 696,953 534,333 399,685 (273,986) (284,685) (193,700) (153,498) (107,852) 648,164 670,523 503,253 380,835 291,833 12,194 17,572 10,731 12,385 12,322 31,825 10,092 (10,092) (256,465) (309,202) (222,850) (179,512) (156,437) (47,075) (37,964) (32,262) (16,304) (11,835) (112,310) (99,345) (78,511) (63,042) (37,090) 286,425 231,492 180,361 134,362 98,793 (3,040) (2,671) (1,853) (1,192) (768) (29,450) (668) (2,418) (273) 253,935 228,153 176,090 133,170 97,752 (40,938) (41,368) (27,087) (20,104) (13,728) 212,997 186,785 149,003 113,066 84,024 229,052 192,830 150,467 113,807 83,906 (16,055) (6,045) (1,464) (741) 118 212,997 186,785 149,003 113,066 84,024 1,009,659 639,392 523,884 284,687 154,179 841,469 729,988 641,771 511,844 255,897 (281,956) (308,179) (272,157) (172,689) (83,497) 559,513 421,809 369,614 339,155 172,400 (52,344) (62,334) (41,440) (30,563) (14,248) 1,516,828 998,867 852,058 593,279 312,331 1,467,438 934,341 786,005 582,156 311,914 49,390 64,526 66,053 11,123 417 1,516,828 998,867 852,058 593,279 312,331
二零一五年年報 8 主席報告 6.9% 25
9 李氏大藥廠控股有限公司 主席報告 Ib/IIa IIaTafoxiparin I RostafuroxinIIb Rostafuroxin Istaroxime IIb PD-L1 Pexa-VecJX-594) Lee s Healthcare Industry Fund L.P. 8,500,000 384,000,000
二零一五年年報 10 主席報告 33% 12,000,000
11 李氏大藥廠控股有限公司 管理層討論及分析 922,150,000 3.5%503,361,000 568,950,000 54.6% 59.6% 418,789,000 386,258,000 45.4% 40.4% 24.0% 16.0% 8.4%
二零一五年年報 12 管理層討論及分析 36% 70.3% 70.2% 0.1 27.8% 32.4% 47,075,000 37,964,000 24.0% 13,033,000 31,825,000 18,792,000 229,052,00018.8%24.8% 20.2%
13 李氏大藥廠控股有限公司 管理層討論及分析 80,000,000 10 GMP GMP 80,000,000 Ib/IIa IIaIb
二零一五年年報 14 管理層討論及分析 Tafoxiparin I Istaroxime IIb Natulan IIb IIb NCT02495012, (PCI)ST (STEMI) 240, 12 (TTP)TTP TTP TTP
15 李氏大藥廠控股有限公司 管理層討論及分析 I Rostafuroxin50 ug 500 ug IIbCVT-CV-001) Rostafuroxin Src-SH2 IIb Rostafuroxin Losartan 17 18320 160 1046044455 (Chi- Mei Medical Center)160 SillaJen, Inc. Pexa-VecJX-594) Pexa-Vec Pexa-Vec (TK) (GM-CSF) Pexa-Vec (HCC)
二零一五年年報 16 管理層討論及分析 13 8,000 Armetheon, Inc. Armetheon Armetheon Tecarfarin Tecarfarin
17 李氏大藥廠控股有限公司 管理層討論及分析 Tragara Pharmaceuticals, Inc. TragaraTragara TG02 TG02 JAK2 FLT3 ERK5 TG02 PD-L1 Solasia Pharma K.K. Solasia Solasia Sancuso Sancuso Laboratorios Salvat, S.A. Salvat Salvat Duoxal Duoxal 6 Lee s Healthcare Industry Fund L.P. 8,500,000 66,300,000 20,200,000 157,600,000
二零一五年年報 18 管理層討論及分析 10,000,000 33% 111,500,000 136,030,000 36,656 65,981 8,400
19 李氏大藥廠控股有限公司 管理層討論及分析 Morgan Stanley & Co. International plc30,000,000 384,000,000 12,000,000 93,000,000 Zingo 31,825,000 33.92% 13,033,000
二零一五年年報 20 管理層討論及分析 33,058,0003.5% 955,208,000 922,150,000 418,789 386,258 +8.4% 503,361 568,950-11.5% 922,150 955,208-3.5% 18.8% 229,052,000 192,830,000 70.3% 70.2% 31,825,000 10,092,000 10,092,000
21 李氏大藥廠控股有限公司 管理層討論及分析 256,465,000 52,737,000 27.8%32.4% 12,965,000 112,310,000 12.2%10.4% 47,075,000 9,111,000 5.1%4.0% 40,938,000 430,00016.1% 18.1% 2
二零一五年年報 22 管理層討論及分析 2.98 2.37327,378,000 340,643,000278,244,000 268,560,000115,903,000 124,352,000 66,769,000 52,269,000 1,321,000
23 李氏大藥廠控股有限公司 管理層討論及分析 46 780 718
二零一五年年報 24 董事及高級管理人員履歷 59 62 53 PhD Warner- Lambert Marco Maria Brughera 60 PhD Marco Maria Brughera Sigma-Tau Rare Disease Business Unit. Sigma-Tau Pharmaceuticals Inc.Sigma-Tau Research Switzerland S.A. Sigma-Tau Pharma Ltd Sigma-Tau Farmitalia Carlo Erba S.p.A., Pharmacia Corporation, Pfizer, Inc. Nerviano Medical Sciences S.r.1. Soligenix, Inc. Brughera Gentium S.p.A. Brughera
25 李氏大藥廠控股有限公司 董事及高級管理人員履歷 53 PhD, MBA, BBA, CFA, MHKSI KBR Capital Limited 54 CPA (Practising), FCCA, BBA 57 PhD, MPhil, BSc
二零一五年年報 26 董事及高級管理人員履歷 57 GMP 46 42 42 MBA BSc GMP
27 李氏大藥廠控股有限公司 董事及高級管理人員履歷 56 MBA, MIA 49 P.E. MSc 53 PhD 41
二零一五年年報 28 董事會報告 8 1011 23 48 20 6 57 0.074 0.066 0.030 0.027 0.104 0.093
29 李氏大藥廠控股有限公司 董事會報告 7 16 37 40 384,000,000
二零一五年年報 30 董事會報告 27% 34% 39% 2,148,000 632,000 61 49 851,454,000 377,131,000 717,925,000 301,196,000 17.28% 22.89% 86.25% 85.52%49.93% 42.64%
31 李氏大藥廠控股有限公司 董事會報告 5% Marco Maria Brughera 112 207,763285,889
二零一五年年報 32 董事會報告 394,895 30% 1. 1.5% 3.5% 2. 15% 15% 15% 3. 96,000 96,000
33 李氏大藥廠控股有限公司 董事會報告 Marco Maria Brughera 96,000 2427
二零一五年年報 34 董事會報告 622
35 李氏大藥廠控股有限公司 董事會報告 10%47,023,543 32,780,543 14,712,00018,554,500 2.5% 3.4% 40 40 18
二零一五年年報 36 董事會報告 XV 352 10 (a) (%) 224,875 1,600,000 1 120,290,625 122,115,500 20.81% 179,500 1,600,000 1 120,290,625 122,070,125 20.80% 38,282,001 2 16,000,000 54,282,001 9.25% 1,040,000 0.18% 300,000 0.05% 300,000 0.05% (1) 120,290,625 Huby Technology LimitedHuby Technology (2) High Knowledge Investments Limited
37 李氏大藥廠控股有限公司 董事會報告 (b) (1) 232,500 (232,500) 3.750 (2) 521,000 (521,000) 4.930 (3) 538,000 538,000 7.300 (4) 446,000 446,000 11.200 1,291,500 446,000 (753,500) 984,000 (3) 538,000 (200,000) 338,000 7.300 (4) 446,000 446,000 11.200 538,000 446,000 (200,000) 784,000 (5) 448,000 (448,000) 1.076 (1) 465,000 (465,000) 3.750 (6) 469,000 (469,000) 2.666 (2) 521,000 (521,000) 4.930 (3) 538,000 (538,000) 7.300 (4) 446,000 446,000 11.200 2,441,000 446,000 (2,441,000) 446,000
二零一五年年報 38 董事會報告 (1) 2 (2) 2 (3) 2 (4) 2 (5) 2 (6) 2 (c) (a)12,740 (b) 830 830 (d) XV XV 352
39 李氏大藥廠控股有限公司 董事會報告 XV 2 3 336 (a) (%) Huby Technology Limited 120,290,625 20.50% Sigma-Tau Finanziaria S.p.A. 142,053,333 24.21% Cavazza Paolo 142,053,333 24.21% Paponi Claudia 142,053,333 24.21% GL Trade Investment Limited 54,485,000 9.29% Assicurazioni Generali S.p.A 54,485,000 9.29% GL Capital Management GP L.P. 54,485,000 9.29% GL Capital Management GP Limited 54,485,000 9.29% GL China Opportunities Fund L.P. 54,485,000 9.29% GL Partners Capital Management 54,485,000 9.29% Limited Li Zhenfu 54,485,000 9.29% Lion River I N.V. 54,485,000 9.29% FMR LLC 1 36,102,500 6.15% High Knowledge Investments Limited 2 16,000,000 2.73% 16,000,000 2.73% 2 3 38,282,001 6.52%
二零一五年年報 40 董事會報告 (b) (%) 3 446,000 0.08% (1) FMR LLC 36,102,500 8,700,000 Fidelity Management & Research (Hong Kong) Limited 11,771,536 FMR Co., Inc.15,416,464 FMR Investment Management (UK) Limited214,500 Pyramis Global Advisors Trust Company (2) High Knowledge Investments Limited (3) (c) XV 2 3
41 李氏大藥廠控股有限公司 董事會報告 47 14A47 14A 14A 14A 1. 4% 8,000,000 8,000,000 4% 2,000,000 2,000,000 22,032,000
二零一五年年報 42 董事會報告 A (a) Sigma-Tau Sigma-Tau Finanziaria S.p.A. (b) (c)swift Power Investments Limited) 9.05% 14A.27 14A.26 33.92% 2. Lee s Healthcare Industry Investment LimitedLee s Healthcare Industry Fund L.P. 20,200,000 157,560,000 1% 8,500,000 66,300,000
43 李氏大藥廠控股有限公司 董事會報告 10,000,000 78,000,000 65% 14A.255% 14A.76(2) 14A 18,685,000 145,743,000 1. Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. STIFR STIFR STIFR 391,010,290 STIFR 38,029,562 STIFR STIFR
二零一五年年報 44 董事會報告 2. STIFR STIFR 4,900,000 STIFR STIFR (i) (ii) (iii) (iv) 3000 740 14A.56
45 李氏大藥廠控股有限公司 董事會報告 3.13 485 5% 1,500 5% 1,500 65
二零一五年年報 46 董事會報告 39 10 4854 14
47 李氏大藥廠控股有限公司 董事會報告
二零一五年年報 48 企業管治報告 A.5 A.5
49 李氏大藥廠控股有限公司 企業管治報告 15/15 1/1 14/15 1/1 15/15 1/1 Marco Maria Brughera 9/15 0/1 9/15 0/1 10/15 0/1 12/15 0/1
二零一五年年報 50 企業管治報告 (i)&(ii) (i)&(ii) (i)&(ii) Marco Maria Brughera (i)&(ii) (i)&(ii) (i)&(ii) (i)&(ii) (i) (ii)
51 李氏大藥廠控股有限公司 企業管治報告 3.21 4/4 100% 4/4 100% 4/4 100%
二零一五年年報 52 企業管治報告 a. b. 11
53 李氏大藥廠控股有限公司 企業管治報告 15 828,000
二零一五年年報 54 企業管治報告 (10%) 2 110-111 (852) 2314 1282 (852) 2314 1708 investor@leespharm.com
55 李氏大藥廠控股有限公司 獨立核數師報告 HLM CPA LIMITED Certified Public Accountants Room 305, Arion Commercial Centre 2-12 Queen s Road West, Hong Kong. 2-12 305 Tel : (852) 3103 6980 Fax : (852) 3104 0170 E-mail : info@hlm.com.hk 57172
二零一五年年報 56 獨立核數師報告 P04084
57 李氏大藥廠控股有限公司 綜合損益表 5 922,150 955,208 (273,986) (284,685) 648,164 670,523 8 12,194 17,572 20B 31,825 10,092 (10,092) (256,465) (309,202) (112,310) (99,345) (47,075) (37,964) 9 286,425 231,492 10 (3,040) (2,671) 20 (29,450) (668) 253,935 228,153 13 (40,938) (41,368) 212,997 186,785 229,052 192,830 (16,055) (6,045) 212,997 186,785 15 39.77 35.52 15 39.29 34.47 57172 14
二零一五年年報 58 綜合損益及其他全面收益表 212,997 186,785 (4,218) 3,319 (56,386) (15,479) (60,604) (12,160) 152,393 174,625 169,501 180,658 (17,108) (6,033) 152,393 174,625 57172
59 李氏大藥廠控股有限公司 綜合財務狀況表 於二零一五年十二月三十一日 16 355,940 302,835 17 337,825 236,218 18 13,401 14,486 19 3,900 3,900 20 58,671 33,863 21 5,491 5,323 22 99,029 42,767 23 135,402 1,009,659 639,392 18 306 324 24 169,878 138,889 25 107,780 99,782 26 108,821 77,735 27 37,275 28 22,588 20,069 674 277 29 115,903 124,352 29 278,244 268,560 841,469 729,988 30 37,621 42,249 31 172,619 182,865 32 505 3,371 33 10,092 34 66,769 52,269 35 303 4,139 17,333 281,956 308,179
二零一五年年報 60 綜合財務狀況表 於二零一五年十二月三十一日 559,513 421,809 1,569,172 1,061,201 37 29,340 27,236 1,438,098 907,105 1,467,438 934,341 38 49,390 64,526 1,516,828 998,867 36 18,281 15,522 39 33,195 46,812 35 868 52,344 62,334 1,569,172 1,061,201 57172 5960
61 李氏大藥廠控股有限公司 綜合權益變動表 27,236 301,196 9,200 7,782 59,344 3,319 7,793 518,471 934,341 64,526 998,867 3,770 3,770 3,770 259 22,547 (2,857) 19,949 19,949 23 23 18 41 1,500 382,147 383,647 383,647 20A 345 12,035 12,380 12,380 1,954 1,954 229,052 229,052 (16,055) 212,997 (4,218) (55,333) (59,551) (1,053) (60,604) (4,218) (55,333) 229,052 169,501 (17,108) 152,393 (38,577) (38,577) (38,577) (17,596) (17,596) (17,596) 29,340 717,925 9,200 8,718 59,344 (899) (47,540) 691,350 1,467,438 49,390 1,516,828
二零一五年年報 62 綜合權益變動表 26,912 292,326 9,200 5,392 60,312 23,284 368,579 786,005 66,053 852,058 3,839 3,839 3,839 324 8,870 (1,472) 7,722 7,722 23 23 18 41 (996) (996) 966 (30) 28 28 4 32 3,518 3,518 192,830 192,830 (6,045) 186,785 3,319 (15,491) (12,172) 12 (12,160) 3,319 (15,491) 192,830 180,658 (6,033) 174,625 (28,251) (28,251) (28,251) (14,687) (14,687) (14,687) 27,236 301,196 9,200 7,782 59,344 3,319 7,793 518,471 934,341 64,526 998,867 57172
63 李氏大藥廠控股有限公司 綜合現金流量表 253,935 228,153 29,450 668 (10,092) 10,092 (31,825) (1,774) (13,617) 23,243 16 33,369 19,370 10 2,609 2,452 (3,832) (2,851) 8 (865) (484) (168) (167) 17 10,814 9,191 18 319 326 17 8,192 5,649 9 23,726 451 9 3,811 3,880 293 1,244 9 (285) (3,296) 1,436 614 (879) 2,775 76 310,174 295,829 (38,697) (21,571) (11,310) (19,385) (35,285) (34,473) (4,594) 5,767 (6,568) 32,383 213,720 258,550 (2,609) (2,452) 175 (50,877) (35,962) 160,234 220,311
二零一五年年報 64 綜合現金流量表 3,832 2,851 (17,245) (14,172) (88,155) (53,707) (10,000) 40 (37,275) (129,030) (58,923) (135,402) (2,000) 801 802 2,000 (57,018) 9,656 (60,480) (39,448) (30) 1,954 3,550 (530,018) (147,381) 33,980 (19,572) (17,199) 1,556 (385) (150) (30) 383,647 19,949 7,722 (56,173) (42,938) 362,972 (52,565) (6,812) 20,365 392,912 379,062 (48,971) (6,515) 337,129 392,912 278,244 268,560 115,903 124,352 394,147 392,912 (57,018) 337,129 392,912 57172
65 李氏大藥廠控股有限公司 1. 2. 19.
二零一五年年報 66 2. 8 12 9 2 15 2 1 1 16 1 38 16 1 41 27 1 10 28 3 10 1 12 28 11 1 1 1 2 3
67 李氏大藥廠控股有限公司 2. 9 9 9 9 (a)(b) 9 39 9
二零一五年年報 68 2. 9 9 39 39 9 39 9 9
69 李氏大藥廠控股有限公司 2. 15 15 15 18 11 15 15 15 15 15 15
二零一五年年報 70 2. 1 1 1 1 16 38 16 38 (a) (b) 16 38
71 李氏大藥廠控股有限公司 2. 16 41 16 41 1641 41 16 41 10 28 10 28 10 28
二零一五年年報 72 2. 10 12 28 10 12 28 10 10 12 28 11 11 3 3 12 36 3
73 李氏大藥廠控股有限公司 2. 11 3 11 5 5 5 7 19
二零一五年年報 74 3. 622 2 17 2 36
75 李氏大藥廠控股有限公司 3.
二零一五年年報 76 3.
77 李氏大藥廠控股有限公司 3. 12 19 2 5
二零一五年年報 78 3. 39
79 李氏大藥廠控股有限公司 3.
二零一五年年報 80 3. 39 36 36
81 李氏大藥廠控股有限公司 3. 39
二零一五年年報 82 3.
83 李氏大藥廠控股有限公司 3.
二零一五年年報 84 3.
85 李氏大藥廠控股有限公司 3.
二零一五年年報 86 3. 5% 1,500
87 李氏大藥廠控股有限公司 3. 40
二零一五年年報 88 3.
89 李氏大藥廠控股有限公司 3.
二零一五年年報 90 3. 5% 20% 20% 33% 20% 33% 20% 50% 10% 100%
91 李氏大藥廠控股有限公司 3.
二零一五年年報 92 3.
93 李氏大藥廠控股有限公司 3.
二零一五年年報 94 3.
95 李氏大藥廠控股有限公司 3.
二零一五年年報 96 3. 39 42
97 李氏大藥廠控股有限公司 3. (a)(b) (c)
二零一五年年報 98 3. 30 120
99 李氏大藥廠控股有限公司 3.
二零一五年年報 100 3.
101 李氏大藥廠控股有限公司 3. 39 42
二零一五年年報 102 3. 37
103 李氏大藥廠控股有限公司 3.
二零一五年年報 104 3. (a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) (vi) (a) (vii) (a)(i)
105 李氏大藥廠控股有限公司 4. 3 5,491,000 5,323,000 21
二零一五年年報 106 4. 3,900,000 19 107,780,000262,000 99,782,000564,000
107 李氏大藥廠控股有限公司 4. 38 8,278,000 355,940,000 302,835,0005% 100% 5. 6.
二零一五年年報 108 6. 8 418,789 386,258 503,361 568,950 922,150 955,208 185,379 168,785 70,316 110,057 255,695 278,842 3,832 2,851 31,825 (4,927) (50,201) 286,425 231,492 (3,040) (2,671) 283,385 228,821 (29,450) (668) 253,935 228,153 (40,938) (41,368) 212,997 186,785
109 李氏大藥廠控股有限公司 6. 3 260,304 236,748 942,067 685,511 1,202,371 922,259 648,757 447,121 1,851,128 1,369,380 87,839 118,746 190,846 172,100 278,685 290,846 55,615 79,667 334,300 370,513
二零一五年年報 110 6. 30,205 17,845 3,164 1,525 33,369 19,370 10,814 9,191 10,814 9,191 81,480 35,918 152,950 90,884 234,430 126,802 351 7,841 5,649 8,192 5,649
111 李氏大藥廠控股有限公司 6. 90% 1,085,401 793,265 765,727 576,115 1,851,128 1,369,380 118,241 198,933 216,059 171,580 334,300 370,513 7. 503,400,000 569,000,000 61,500,000 95,900,000 10% 8. 3,832 2,851 168 167 865 484 4,865 3,502 6,616 8,714 1,774 713 3,582 12,194 17,572
二零一五年年報 112 9. 33,369 19,370 10,814 9,191 44,183 28,561 1,353 879 23,726 (451) 630 745 130,659 149,087 3,811 3,880 47,075 37,964 7,885 6,526 (285) (3,296) 1,436 244,184 264,967 (10,092) 10,092 10. 2,538 2,448 71 4 2,609 2,452 431 219 3,040 2,671
113 李氏大藥廠控股有限公司 11. * 2,493 810 18 3,321 (4,322) 382 (619) * 3,431 1,115 18 4,564 (9,845) 267 (5,014) * 4,739 1,540 18 6,297 550 205 7,052 Marco Maria Brughera 96 96 96 96 96 96 96 96 96 96 96 96 384 10,663 3,465 54 14,566 (13,617) 854 1,803 *
二零一五年年報 114 11. 2,285 942 17 3,244 6,832 362 10,438 3,144 1,296 17 4,457 12,961 213 17,631 4,343 1,790 17 6,150 3,450 490 10,090 Mauro Bove 34 34 139 173 Marco Maria Brughera 96 96 96 96 96 96 94 94 94 320 9,772 4,028 51 14,171 23,243 1,204 38,618 66,000 40
115 李氏大藥廠控股有限公司 11. 12. 11 5,679 2,752 36 17 333 6,048 2,769 1,000,0012,000,000 1 2 4,000,0015,000,000 1 2 2
二零一五年年報 116 13. 25,300 25,875 12,161 13,153 142 1,233 37,603 40,261 3,335 1,107 40,938 41,368 16.5% 15% 25% 15% 25%
117 李氏大藥廠控股有限公司 13. 253,935 228,153 37,235 32,495 4,859 110 9,653 6,554 (20,793) (3,460) 142 1,233 (2,187) (7,218) 17,085 14,681 (5,559) (3,146) 503 119 40,938 41,368 89,000,000 64,000,000
二零一五年年報 118 14. 0.030 0.027 17,596 14,687 0.074 0.066 43,423 35,952 61,019 50,639 7.46.6 15. 229,052 192,830 41 229,052 192,871
119 李氏大藥廠控股有限公司 15. 575,986 542,871 7,026 9,780 6,905 583,012 559,556 48Lee s Pharmaceutical International Limited 1.80
二零一五年年報 120 16. 26,771 2,912 62,544 20,150 6,530 183,167 302,074 (787) (1) (1,836) (385) (131) (4,994) (8,134) (38) 140 (102) 250 5,526 7,132 1,264 53,707 67,879 12,439 24,776 66 (37,281) (2,921) (8,548) (5,175) (276) (16,920) 35,502 3,123 82,602 21,686 7,663 194,323 344,899 (2,802) (2) (3,647) (1,263) (352) (13,707) (21,773) 20,187 (29,326) 9,139 699 235 4,407 9,277 2,627 88,155 105,400 1,498 5,015 (6,513) (5,725) (5,725) 55,084 3,356 59,051 33,114 9,938 262,258 422,801 7,438 2,509 15,856 10,521 2,677 39,001 (192) (1) (452) (156) (62) (863) (23) 23 1,776 233 11,781 4,408 1,172 19,370 (2,348) (7,967) (5,129) (15,444) 6,674 2,718 19,218 9,667 3,787 42,064 (718) (1) (1,234) (657) (237) (2,847) 1,822 (7,618) 5,796 7,170 182 12,648 11,063 2,306 33,369 (5,725) (5,725) 14,948 2,899 23,014 20,144 5,856 66,861 40,136 457 36,037 12,970 4,082 262,258 355,940 28,828 405 63,384 12,019 3,876 194,323 302,835
121 李氏大藥廠控股有限公司 16. 4,082,0001,321,000 17. 101,985 108,482 210,467 (62) (2,139) (2,201) 20,753 38,170 58,923 (5,649) (5,649) 122,676 138,864 261,540 (1,346) (7,641) (8,987) 34,898 94,132 129,030 (901) (7,377) (8,278) 155,327 217,978 373,305 9,200 7,138 16,338 (207) (207) 6,984 2,207 9,191 16,184 9,138 25,322 (570) (570) 9,241 1,573 10,814 (86) (86) 25,339 10,141 35,480 129,988 207,837 337,825 106,492 129,726 236,218
二零一五年年報 122 18. 14,810 15,546 (784) (410) 14,026 15,136 (319) (326) 13,707 14,810 (306) (324) 13,401 14,486 19. 3,900 3,900 10% 10%
123 李氏大藥廠控股有限公司 20. 91,208 36,949 (32,537) (3,086) 58,671 33,863 33.92% 39.65% 33.92% 39.65% 33.92% 33.92% RIT Biotech (Holding) 33.33% 33.33% Company Limited RIT Biotech Company Ltd 33.33% 33.33%
二零一五年年報 124 20. A. 6,894,23911,660 39.65% 56.63% B. 56.63%33.92% 31,825,000 C.
125 李氏大藥廠控股有限公司 20. C. 63,881 6,094 35,686 72,050 25,411 (38,739) (24) 6,438 17,582 (57,299) (125) (58,436) (1,684) (58,436) (1,684)
二零一五年年報 126 20. C. 74,156 39,381 33.92% 39.65% 23,995 18,249 49,148 33,863 RIT Biotech (Holding) Company Limited RIT 16,492 24
127 李氏大藥廠控股有限公司 20. C. RIT Biotech (Holding) Company Limited RIT 5 (1,432) (1,432) (1,432) RIT 16,468 RIT 33.33% RIT 9,523 RIT RIT
二零一五年年報 128 21. 5,491 5,323 3.283.28 22. 1 27,015 31,233 2 39,060 11,534 3 32,954 99,029 42,767 1. 2. 3. Lee s Healthcare Industry Fund L.P.
129 李氏大藥廠控股有限公司 23. 24. 11,031 15,972 14,134 22,036 144,713 100,881 169,878 138,889 25. 108,042 100,346 (262) (564) 107,780 99,782 30 120 365100% 365 180
二零一五年年報 130 25 0 30 50,767 35,640 31 120 50,236 57,433 121 180 5,839 4,571 181 365 934 2,004 365 4 134 107,780 99,782 1 180 20,244 18,520 181 365 257 521 20,501 19,041
131 李氏大藥廠控股有限公司 25. 564 3,910 (17) (50) (285) (3,296) 262 564 181 365 258 521 365 4 43 262 564 26. 3,143 2,691 69,275 52,628 16,722 685 19,681 21,731 108,821 77,735
二零一五年年報 132 27. Lee s Healthcare Industry Fund L.P. 37,275 Lee s Healthcare Industry Fund L.P. 28. 47(c) 29. 0.01% 0.39% 0.01% 1.06%0.35% 3.46% 0.70% 3.60% 30. 0 90 35,523 42,227 91 180 1 181 365 2,065 10 365 32 12 37,621 42,249 90
133 李氏大藥廠控股有限公司 31. 15,092 29,510 33,611 51,806 84,289 19,408 15,056 56,803 49,909 172,619 182,865 32. 33. 10,092 10,092 (10,092) 10,092 10,092 42
二零一五年年報 134 34. (1) 66,769 52,269 (2) 34,146 16,207 23,804 16,245 8,819 19,817 66,769 52,269 (1) 5 (2) 2.53% 4.50% 3.00% 4.12% 52,697 9,056 5,016 52,269
135 李氏大藥廠控股有限公司 35. 3.72% 342 303 912 868 1,254 1,171 (83) 1,171 1,171 (303) 868
二零一五年年報 136 36. 112 14,549 14,661 (246) (246) (159) 1,266 1,107 (47) 15,569 15,522 (576) (576) 195 8,682 (5,542) 3,335 148 23,675 (5,542) 18,281 368,000,000 250,000,000
137 李氏大藥廠控股有限公司 37. 0.05 1,000,000,000 1,000,000,000 50,000 50,000 544,720,604 538,245,604 27,236 26,912 5,180,500 6,475,000 259 324 30,000,000 1,500 20A 6,894,239 345 586,795,343 544,720,604 29,340 27,236 38. 64,494 32 64,526 1,954 1,954 (16,055) (16,055) (1,053) (1,053) 18 18 49,340 50 49,390
二零一五年年報 138 38. 66,039 14 66,053 966 966 4 4 3,518 3,518 (6,045) (6,045) 12 12 18 18 64,494 32 64,526 43.74% 43.74% 35% 35%
139 李氏大藥廠控股有限公司 39. 5% 1,500 1,500 650,429 494,517 132,748 114,245 Messrs. Ascent Partners Valuation Service Limited
二零一五年年報 140 40. 14,712,00018,554,500 2.5% 3.4% 10% 1% 10% 10%10% 30% (i) (ii)(iii)
141 李氏大藥廠控股有限公司 40. 448,000 (448,000) 1.076 697,500 (697,500) 3.750 469,000 (469,000) 2.666 1,042,000 (1,042,000) 4.930 1,614,000 (738,000) 876,000 7.300 1,338,000 1,338,000 11.200 500,000 (500,000) 0.159 500,000 500,000 0.175 320,000 320,000 0.492 660,000 (420,000) 240,000 2.200 300,000 300,000 3.750 5,614,000 (650,000) 4,964,000 4.996 300,000 300,000 5.620 2,040,000 (16,000) 2,024,000 7.300 600,000 600,000 10.340 750,000 750,000 10.340 500,000 500,000 0.175 2,000,000 2,000,000 0.492 200,000 (200,000) 3.750 18,554,500 1,338,000 (5,180,500) 14,712,000 12,541,000 4.558 11.200 3.859 5.409 12.00
142 二零一五年年報 40. (i) 50% (ii) 0.159 (i) 50% (ii) 0.175 (i) 50% (ii) 0.492 (i) 50% (ii) 1.076
143 李氏大藥廠控股有限公司 40. (i) (ii) 50% 2.200 (i) (ii) 50% 3.750 (i) 50% (ii) 2.666 (i) (ii) 259,500 259,500 4.996 (iii) 1,160,000 (iv) 2,230,000 (v) 2,650,000
144 二零一五年年報 40. (i) 50% (ii) 4.930 (i) 50% 5.620 (ii) (i) 1,614,00050% 7.300 (ii) 669,000 (iii) 669,000 (iv) 702,000
145 李氏大藥廠控股有限公司 40. (i) 600,00050% 10.340 50% (ii) 250,000 (iii) 250,000 (iv) 250,000 (i) 669,000 11.200 (ii) 669,000
二零一五年年報 146 40. 1,291,500 446,000 (753,500) 984,000 538,000 446,000 (200,000) 784,000 2,441,000 446,000 (2,441,000) 446,000 4,270,500 1,338,000 (3,394,500) 2,214,000 11,584,000 (1,586,000) 9,998,000 2,700,000 (200,000) 2,500,000 18,554,500 1,338,000 (5,180,500) 14,712,000
147 李氏大藥廠控股有限公司 40. 5,009,000 Black-Scholes 1. 11.200 2. 38.040% 40.590% 3. 4. 1.092% 5. 1.128% 1.178% Messrs. Ascent Partners Valuation Service Limited Black-Scholes Black-Scholes
二零一五年年報 148 40. 440,000440,000 3.26% 3.26% 500,000 30% 133,000 133,000 a 1.628 267,000 267,000 b 1.628 40,000 40,000 1.628 440,000 440,000 40,000 1.628 1.628
149 李氏大藥廠控股有限公司 40. a. Rostafuroxin Istaroxime b. Rostafuroxin Istaroxime (i) 133,000 Rostafuroxin Istaroxime 1.628 (i) 267,000 Rostafuroxin Istaroxime 1.628 (i) 40,000 1.628 3,811,000 3,880,000
二零一五年年報 150 41. 1 67,940 52,269 (337,129) (392,912) (269,189) (340,643) 2 1,467,438 934,341 (1) 34 35 (2)
151 李氏大藥廠控股有限公司 42. 5,491 5,323 607,766 528,114 99,029 42,767 712,286 576,204 264,213 277,830 10,092 264,213 287,022
二零一五年年報 152 42. 320,599 327,707 107,511 161,818 146,266 137,707 10,189 4,021 3,830 25,193 64,161 47,887 20,429 343 751 5,402 491,124 490,950 188,014 213,726
153 李氏大藥廠控股有限公司 42. 5% 5% 5% 5% 5% 5% 40 1,301 11,160 6,994 6,804 6,684 (3,017) (1,135) 804 17 (270) 3,557 6,850 11,964 7,011
二零一五年年報 154 42. 5050 5050 279,000 218,000 5% 5% 1,351,000 1,562,000
155 李氏大藥廠控股有限公司 42. 46
二零一五年年報 156 42. 46
157 李氏大藥廠控股有限公司 42. % 158,434 158,434 158,434 505 505 505 3.72 28 57 257 912 1,254 1,171 1 2.53-4.50 1,508 4,015 30,209 34,101 69,833 66,769 4,139 4,139 4,139 164,614 4,072 30,466 35,013 234,165 231,018
二零一五年年報 158 42. % 140,824 140,824 140,824 562 2,809 3,371 3,371 1 3.00-4.12 1,139 3,279 13,253 37,713 55,384 52,269 17,333 17,333 17,333 159,858 3,279 16,062 37,713 216,912 213,797 17,493 34,722 52,083 104,298 (20,548) (41,096) (61,179) (122,823) (3,055) (6,374) (9,096) (18,525) (10,092) 1. 1
159 李氏大藥廠控股有限公司 42. 27,015,000 31,2330,000 10,092,000 Monte Carlo 6.23% 33,195,000 46,812,000 4.1% 2.58% 4.07% A 4.14% 6.42%
二零一五年年報 160 42. 10,092 46,812 56,904 (10,092) (13,617) (23,709) 33,195 33,195 23,569 23,569 10,092 23,243 33,335 10,092 46,812 56,904
161 李氏大藥廠控股有限公司 43. 7,885 6,526 7,235 6,167 6,542 6,548 13,777 12,715 1 5 44. 36,431 14,793 71,147 40,862 20,020 10,178 22,081 25,334 149,679 91,167 12,000,000
二零一五年年報 162 45. 1,321,000 46. 8,000 6,000 47. (a) Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Sigma-Tau Industrie (1)/(2) 38,029 93,565 Farmaceutiche Riunite S.p.A. STIFR STIFR (1)/(3) 2,899 2,941 40,928 96,506
163 李氏大藥廠控股有限公司 47. (a) Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. 1. Sigma-Tau STIFR STIFR STIFR STIFR 2. 14A 14A 3. 14A 14A (b) 14,566 14,171 854 1,204 (13,617) 23,243 1,803 38,618
二零一五年年報 164 47. (c) * 4 8,000,000 * 4 2,000,000 4 4,032,080 4 4,000,000 4 4,000,000 * 14A 14A 8 865,000 484,000 A (a) Sigma-Tau Sigma-Tau Finanziaria S.p.A. (b) (c)swift Power Investments Limited)9.05% 14A.27 14A.26
165 李氏大藥廠控股有限公司 47. (d) 3,500 252,000 1,954,000 (e) Lee s Healthcare Industry Fund L.P. Lee s Healthcare Industry Fund L.P. 8,500,000 66,300,000 14A 14A (f) 1,300,000
二零一五年年報 166 48. A. Lee s Pharmaceutical 1 100% 100% International Limited 1,000,000 100% 100% 18,400,000 100% 100% 2,000,000 100% 100% 1 40,000 65% 65%
167 李氏大藥廠控股有限公司 48. A. 16,000,000 100% 100% 1 1 100% 100% 1,500,000 100% 100% 1 135,000 56.26% 56.26% 314,030,970 56.26% 56.26% 500,000 56.26% 56.26% 19,000,000 100% 1 2 1. 2.
二零一五年年報 168 48. B. 43.74% 43.74% (13,883) (5,272) 46,090 61,008
169 李氏大藥廠控股有限公司 48. B. 25,972 70,910 88,833 72,668 9,376 4,100 56 105,373 139,478 46,090 61,008 8,921 5,221 (40,660) (17,274) (31,739) (12,053) (17,856) (6,781) (13,883) (5,272) (31,739) (12,053)
二零一五年年報 170 48. B. (1,353) (1,053) (2,406) (19,209) (6,781) (14,936) (5,272) (34,145) (12,053) (9,524) (14,373) (29,845) (21,244) (39,369) (35,617)
171 李氏大藥廠控股有限公司 49. 736,525 397,235 10,000 5,491 5,323 99,029 42,767 851,045 445,325 621 2,264 37,275 211 277 17,754 7,796 10,956 6,649 66,817 16,986 3,873 11,132 62,944 5,854 913,989 451,179 29,340 27,236 851,454 377,131 880,794 404,367 33,195 46,812 913,989 451,179
二零一五年年報 172 49. 301,196 9,200 7,730 3,319 55,686 377,131 3,770 3,770 22,547 (2,857) 19,690 12,035 12,035 382,147 382,147 117,072 117,072 (4,218) (4,218) (4,218) 117,072 112,854 (38,577) (38,577) (17,596) (17,596) 717,925 9,200 8,643 (899) 116,585 851,454 292,326 9,200 5,363 46,005 352,894 3,839 3,839 8,870 (1,472) 7,398 52,619 52,619 3,319 3,319 3,319 52,619 55,938 (28,251) (28,251) (14,687) (14,687) 301,196 9,200 7,730 3,319 55,686 377,131