2014
目 錄 2 3 5 7 8 11 21 26 41 47 49 50 51 53 54 56 58
公司資料 950 Marco Maria Brughera P.O. Box 309 GT, Ugland House South Church Street, George Town Grand Cayman, Cayman Islands 2 110-111 183 17 1712-1716 www.leespharm.com 2 二零一四年年報
公司簡介 950 3 李氏大藥廠控股有限公司
公司簡介 * * * * * Aloxi UNIDROX 4 * 二零一四年年報
財務概要 955,208 696,953 +37.1% 192,830 150,467 +28.2% 934,341 786,005 +18.9% 35.52 28.41 +25.0% 34.47 27.05 +27.4% 5 2.7 2.3 6.6 5.2 9.3 7.5 +20.0% 26.2% 26.4% 李氏大藥廠控股有限公司
財務概要 1,200,000 250,000 1,000,000 955,208 200,000 192,830 800,000 696,953 150,000 150,467 600,000 534,333 113,807 400,000 200,000 255,810 399,685 100,000 50,000 58,026 83,906 0 2010 2011 2012 2013 2014 0 2010 2011 2012 2013 2014 6 1,000,000 800,000 786,005 934,341 40 35 30 28.41 35.52 600,000 582,156 25 22.82 20 17.9 400,000 200,000 241,064 311,914 15 10 5 12.8 0 2010 2011 2012 2013 2014 0 2010 2011 2012 2013 2014 二零一四年年報
五年財務摘要 955,208 696,953 534,333 399,685 255,810 (284,685) (193,700) (153,498) (107,852) (77,320) 670,523 503,253 380,835 291,833 178,490 17,572 10,731 12,385 12,322 5,770 (10,092) (309,202) (222,850) (179,512) (156,437) (79,193) (37,964) (32,262) (16,304) (11,835) (5,590) (99,345) (78,511) (63,042) (37,090) (29,299) 231,492 180,361 134,362 98,793 70,178 (668) (2,418) (273) (1,159) (2,671) (1,853) (1,192) (768) (1,058) 7 228,153 176,090 133,170 97,752 67,961 (41,368) (27,087) (20,104) (13,728) (10,039) 186,785 149,003 113,066 84,024 57,922 192,830 150,467 113,807 83,906 58,026 (6,045) (1,464) (741) 118 (104) 186,785 149,003 113,066 84,024 57,922 639,392 523,884 284,687 154,179 105,343 729,988 641,771 511,844 255,897 206,370 (308,179) (272,157) (172,689) (83,497) (61,021) 421,809 369,614 339,155 172,400 145,349 (62,334) (41,440) (30,563) (14,248) (9,344) 998,867 852,058 593,279 312,331 241,348 934,341 786,005 582,156 311,914 241,064 64,526 66,053 11,123 417 284 998,867 852,058 593,279 312,331 241,348 李氏大藥廠控股有限公司
主席報告 37.1% 955,208,00028.2% 192,830,000 64.9% 69.3% 8 GMPGMP GMP GSP INSIGHT-China Pharma Data 二零一四年年報
主席報告 4,000 Mictonorm 30 Mictonorm Mictonorm 9 I II ST IIaSTIIb Istaroxime IIb Istaroxime 李氏大藥廠控股有限公司
主席報告 Sorrento PD-L1 PD-1 PD-L1 INOMax Neridronate Acid 120 Zingo EyeSense AG 10 二零一四年年報
管理層討論及分析 24 11 955,208,00037.1% 38.5% 64.9% 39.6% 31.1% 69.3% 12.2% 2 70.2% GMP 32.4% 0.4 32,262,000 37,964,000192,830,00028.2% 33.9% 20.2%1.4 李氏大藥廠控股有限公司
管理層討論及分析 4,600 GMP 57,000 GSP 60% PD-L1 12 PIC S GMP Zingo GMP Zingo INSIGHT-China Pharma Data 4,000 二零一四年年報
管理層討論及分析 200810004156.1 I II 13 Istaroxime IIb 24 Istaroxime IIa IIa NCT01585259 (PCI) ST(NSTEMI) IIa III ST (STEMI) IIbIIb 李氏大藥廠控股有限公司
管理層討論及分析 TTP TTP TTP Prulifloxacin IIIPrulifloxacin Prulifloxacin QT Prulifloxacin IDL H20140799 Mictonorm 30Mictonorm Mictonorm 14 Dilafor AB tafoxiparin Dilafor tafoxiparin Tafoxiparin Dilafor 二零一四年年報
管理層討論及分析 Sodium Neridronate Neridronate (CRPS) Neridronate Fondaparinux Travoprost Bimatoprost 15 D3 D D 65% Sorrento Therapeutics, Inc. Sorrento PD-L1 (mab)sti-a1014 Sorrento PD-L1 Sorrento PD-L1 3,600,000 27,900,000 Sorrento Sorrento PD-L1 PD-1 FDA 李氏大藥廠控股有限公司
管理層討論及分析 EyeSense AG EyeSense AG EyeSense AG Ikaria, Inc. Ikaria INOmax Ikaria, Inc. INOmax FDA 34(HRF) INOmax INOmax II III 16 1,800 二零一四年年報
管理層討論及分析 110% 120 17 MSCI HSBCI HSMCGI HSGCI HSCI 258,255,000 37.1% 696,953,000 955,208,000 * 192,830,000 28.2% 李氏大藥廠控股有限公司
管理層討論及分析 70.2% 72.2% 2.0 GMP 32.4%32.0% 0.4 5,702,00037,964,000 10,092,000 26.5% 99,345,000 18 182,865,000145,365,000 37,500,000 2.37 2.36 340,643,000 311,594,000 268,560,000 202,625,000 124,352,000176,437,000 2,000,00052,269,000 69,468,000 二零一四年年報
管理層討論及分析 19 2,000,000 544,338 718 594 152,967,000103,960,000 李氏大藥廠控股有限公司
管理層討論及分析 Mictonorm 1 20 Nicetile Dromos Trittico 二零一四年年報
董事及高級管理人員履歷 58 61 21 52 PhD Warner-Lambert Marco Maria Brughera 59 Marco Maria Brughera Brughera Sigma-Tau Rare Disease Business Unit.Sigma-Tau Pharmaceuticals Inc. Sigma-Tau Research Switzerland S.A. Sigma-Tau Pharma Ltd Sigma-TauFarmitalia Carlo Erba S.p.A., Pharmacia Corporation, Pfizer, Inc. Nerviano Medical Sciences S.r.1. Soligenix, Inc. Brughera Gentium S.p.A. Brughera 李氏大藥廠控股有限公司
董事及高級管理人員履歷 52 PhD, MBA, BBA, CFA, MHKSI KBR Capital Limited 53 CPA (Practising), FCCA, BBA 22 56 PhD, MPhil, BSc 二零一四年年報
董事及高級管理人員履歷 56 GMP 45 23 41 李氏大藥廠控股有限公司
董事及高級管理人員履歷 41 MBA BSc GMP 55 MBA, MIA 48 P.E. MSc 24 二零一四年年報
董事及高級管理人員履歷 52 PhD 40 25 37 MD. PhD IESE CEOASLAN 李氏大藥廠控股有限公司
董事會報告 6 49162 0.066 0.052 26 0.027 0.023 0.093 0.075 48 20 7 二零一四年年報
董事會報告 16 33 39 27 632,000731,000 34 54 377,131,000352,894,000 301,196,000292,326,000 李氏大藥廠控股有限公司
董事會報告 22.89% 17.98% 85.52% 87.67% 42.64% 51.58% 5% 28 Marco Maria Brughera 95 112 Marco Maria Brughera 二零一四年年報
董事會報告 190,424262,031 361,940 30% 29 1. 1.5% 3.5% 2. 15% 15% 15% 3. 李氏大藥廠控股有限公司
董事會報告 96,000 96,000 Marco Maria Brughera 96,000 30 10% 47,023,543 34,118,543 18,554,500 23,679,500 3.4% 4.4% 39 二零一四年年報
董事會報告 39 18 31 XV 352 10 (a) (%) 183,875 1,600,000 1 120,290,625 122,074,500 22.41% 126,000 1,600,000 1 120,290,625 122,016,625 22.40% 34,957,667 2 16,000,000 50,957,667 9.35% 1,040,000 1,040,000 0.19% 300,000 300,000 0.06% 300,000 300,000 0.06% 李氏大藥廠控股有限公司
董事會報告 (1) 120,290,625Huby Technology Limited Huby Technology Huby Technology (2) High Knowledge Investments Limited High Knowledge (b) (1) 232,500 232,500 3.750 (2) 521,000 521,000 4.930 (3) 538,000 538,000 7.300 32 1,291,500 1,291,500 (6) 319,000 (319,000) 4.996 (3) 538,000 538,000 7.300 857,000 (319,000) 538,000 (4) 448,000 448,000 1.076 (1) 465,000 465,000 3.750 (5) 469,000 469,000 2.666 (2) 521,000 521,000 4.930 (3) 538,000 538,000 7.300 2,441,000 2,441,000 二零一四年年報
董事會報告 (1) 2 (2) 2 (3) 2 (4) 2 (5) 2 (6) 2 (c) 12,550 1,750 330,113 33 (d) XV XV 352 李氏大藥廠控股有限公司
董事會報告 XV 2 3336 (a) (%) Huby Technology Limited 120,290,625 22.08% Sigma-Tau Industrie 137,720,000 25.28% Farmaceutiche Riunite S.p.A. Sigma Tau Finanziaria S.p.A. 137,720,000 25.28% Cavazza Paolo 137,720,000 25.28% Paponi Claudia 137,720,000 25.28% GL Trade Investment Limited 54,485,000 10.00% Assicurazioni Generali S.p.A 54,485,000 10.00% GL Capital Management GP L.P. 54,485,000 10.00% GL Capital Management GP Limited 54,485,000 10.00% GL China Opportunities Fund L.P. 54,485,000 10.00% GL Partners Capital Management 54,485,000 10.00% Limited Li Zhenfu 54,485,000 10.00% Lion River I N.V. 54,485,000 10.00% FIL Limited 32,465,000 5.96% High Knowledge Investments Limited 1 16,000,000 2.94% 16,000,000 2.94% 1 2 34,957,667 6.42% 34 二零一四年年報
董事會報告 (b) (%) 2 2,771,113 0.51% (1) High Knowledge Investments Limited (2) (b) 35 XV 2 3 1. 4% 8,000,000 8,000,000 4% 520,000 4,032,080 4% 4,000,000 4,000,000 4% 4,000,000 4,000,000 李氏大藥廠控股有限公司
董事會報告 6,000,000 1,000,000 6,000,000 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Sigma-Tau Sigma-Tau 10% 39.65% 2. Sigma-Tau Istaroxime Sigma-Tau Istaroxime Sigma-Tau Istaroxime 840,000 36 3. Sigma-Tau Sigma-Tau Sigma-Tau 2,520,000 2,298,960 二零一四年年報
董事會報告 1. Sigma-Tau Istaroxime Rostafuroxin Sigma-Tau Sigma-Tau Istaroxime Rostafuroxin Istaroxime 1,835,349 4,000,000 Sigma-Tau 1,105,415 4,000,000 37 2,940,764 8,000,000 2. Sigma-Tau Sigma-Tau 1,000,000 3. Sigma-Tau Sigma-TauSigma-Tau Sigma-Tau 202,833,780 Sigma-Tau 93,564,615 李氏大藥廠控股有限公司
董事會報告 a. b. c. d. a. b. c. 38 25% 3.13 二零一四年年報
董事會報告 38 39 10 4146 14 李氏大藥廠控股有限公司
董事會報告 40 二零一四年年報
企業管治報告 A.5 A.5 41 李氏大藥廠控股有限公司
企業管治報告 42 二零一四年年報
企業管治報告 14/14 1/1 14/14 1/1 14/14 1/1 Marco Maria Brughera* 0/0 0/0 43 14/14 0/1 14/14 0/1 12/14 0/1 * Marco Maria Brughera 李氏大藥廠控股有限公司
企業管治報告 3.21 44 4/4 100% 4/4 100% 3/4 75% a. 二零一四年年報
企業管治報告 b. 2 11 45 15 李氏大藥廠控股有限公司
企業管治報告 879,000 (10%) 46 2 110-111 (852) 2314 1282 (852) 2314 1708 investor@leespharm.com 二零一四年年報
獨立核數師報告 HLM CPA LIMITED Certified Public Accountants Room 305, Arion Commercial Centre 2-12 Queen s Road West, Hong Kong. 2-12 305 Tel : (852) 3103 6980 Fax : (852) 3104 0170 E-mail : info@hlm.com.hk 49162 47 李氏大藥廠控股有限公司
獨立核數師報告 48 P04084 二零一四年年報
綜合損益表 5 955,208 696,953 (284,685) (193,700) 670,523 503,253 8 17,572 10,731 (10,092) (309,202) (222,850) (37,964) (32,262) (99,345) (78,511) 49 9 231,492 180,361 20 (668) (2,418) 10 (2,671) (1,853) 228,153 176,090 13 (41,368) (27,087) 186,785 149,003 192,830 150,467 (6,045) (1,464) 186,785 149,003 15 35.52 28.41 15 34.47 27.05 58162 14 李氏大藥廠控股有限公司
綜合損益及其他全面收益表 186,785 149,003 71 (15,479) 8,649 3,319 (12,160) 8,720 174,625 157,723 180,658 159,186 (6,033) (1,463) 50 174,625 157,723 58162 二零一四年年報
綜合財務狀況表 於二零一四年十二月三十一日 16 302,835 263,073 17 236,218 194,129 18 14,486 15,213 19 3,900 3,900 20 33,863 34,531 21 5,323 5,156 22 42,767 7,882 639,392 523,884 51 18 324 333 23 138,889 117,881 24 99,782 78,320 77,735 43,788 25 20,069 20,387 277 26 2,000 26 124,352 176,437 26 268,560 202,625 729,988 641,771 27 42,249 36,493 182,865 145,365 28 3,371 7,923 29 10,092 30 52,269 69,468 31 150 17,333 12,758 308,179 272,157 李氏大藥廠控股有限公司
綜合財務狀況表 於二零一四年十二月三十一日 421,809 369,614 1,061,201 893,498 33 27,236 26,912 34 907,105 759,093 934,341 786,005 35 64,526 66,053 998,867 852,058 52 32 15,522 14,661 38 46,812 23,569 28 3,210 62,334 41,440 1,061,201 893,498 58162 49162 二零一四年年報
財務狀況表 於二零一四年十二月三十一日 17 3,840 48 397,235 340,396 21 5,323 5,156 22 42,767 7,882 445,325 357,274 2,264 360 277 26 7,796 38,591 26 6,649 10,686 16,986 49,637 53 11,132 3,351 185 11,132 3,536 5,854 46,101 451,179 403,375 33 27,236 26,912 34 377,131 352,894 404,367 379,806 38 46,812 23,569 451,179 403,375 58162 李氏大藥廠控股有限公司
綜合權益變動表 26,912 292,326 9,200 5,392 60,312 23,284 368,579 786,005 66,053 852,058 3,839 3,839 3,839 324 8,870 (1,472) 7,722 7,722 23 23 18 41 36 (996) (996) 966 (30) 37 28 28 4 32 3,518 3,518 192,830 192,830 (6,045) 186,785 3,319 (15,491) (12,172) 12 (12,160) 3,319 (15,491) 192,830 180,658 (6,033) 174,625 (28,251) (28,251) (28,251) (14,687) (14,687) (14,687) 54 27,236 301,196 9,200 7,782 59,344 3,319 7,793 518,471 934,341 64,526 998,867 二零一四年年報
綜合權益變動表 26,055 260,656 9,200 3,292 17,038 4,036 14,636 247,243 582,156 11,123 593,279 2,727 2,727 2,727 99 5,300 (654) 4,745 4,745 27 27 13 40 (4,107) 4,107 758 26,370 27,128 27,128 43,274 43,274 56,380 99,654 150,467 150,467 (1,464) 149,003 71 8,648 8,719 1 8,720 55 71 8,648 150,467 159,186 (1,463) 157,723 (20,871) (20,871) (20,871) (12,367) (12,367) (12,367) 26,912 292,326 9,200 5,392 60,312 23,284 368,579 786,005 66,053 852,058 58162 39 李氏大藥廠控股有限公司
綜合現金流量表 228,153 176,090 668 2,418 10,092 (1,774) 23,243 12,678 19,370 11,518 2,452 1,555 (2,851) (2,717) (484) (444) (128) (167) (56) 9,191 4,640 326 345 5,649 6,094 451 405 3,880 2,767 293 164 (3,296) (1,033) 1,436 3,308 (879) 889 76 1,455 56 295,829 219,948 (21,571) (54,995) (19,385) (5,384) (34,473) (9,739) 5,767 7,298 32,383 50,046 258,550 207,174 (2,452) (1,555) 175 (35,962) (26,353) 220,311 179,266 二零一四年年報
綜合現金流量表 2,851 2,717 (14,172) (32,697) (53,707) (113,169) 40 51 (58,923) (76,190) (16,000) 802 2,562 2,000 9,656 36 (30) (39,448) (7,754) (5,100) 3,550 99,654 57 (147,381) (145,926) 50,000 (17,199) (12,015) (150) (732) (172) 7,722 4,745 (42,938) (33,238) (52,565) 8,588 20,365 41,928 379,062 333,902 (6,515) 3,232 392,912 379,062 268,560 202,625 124,352 176,437 392,912 379,062 58162 李氏大藥廠控股有限公司
1. 2. 10 1227 10 12 27 10 58 二零一四年年報
2. 10 1227 1227 10 59 32 32 32 36 36 36 13 李氏大藥廠控股有限公司
2. 39 39 39 21 21 21 60 21 二零一四年年報
2. 61 9 6 14 3 15 5 1 4 16 4 38 16 4 41 19 1 27 4 10 28 4 10 4 1228 11 4 2 1 4 李氏大藥廠控股有限公司
2. 1 2 3 4 5 6 9 9 9 9 a) b) 62 9 39 9 二零一四年年報
2. 9 9 39 63 39 9 9 李氏大藥廠控股有限公司
2. 15 15 15 18 11 15 64 15 15 15 15 15 二零一四年年報
2. 1 1 1638 16 38 65 (a) (b) 1638 李氏大藥廠控股有限公司
2. 1641 1641 16 41 41 1641 19 19 66 19 二零一四年年報
2. 27 99 39 28 67 27 28 10 1 27 李氏大藥廠控股有限公司
2. 1028 28 10 68 10 二零一四年年報
2. 1028 1028 10 1228 10 1228 69 11 113 3 36 3 11 11 李氏大藥廠控股有限公司
2. 2 (i) (ii) 2 3 939 3 70 8 (i) (ii) 13 13 39 9 二零一四年年報
2. 1638 24 71 3 13 39 9 39 9 32 李氏大藥廠控股有限公司
2. 40 40 3 (a) (b) 40 3 5 5 72 7 7 34 二零一四年年報
2. 19 3434 73 6223589 9 李氏大藥廠控股有限公司
3. 622 11 76 87 9 32 2 17 2 36 74 二零一四年年報
3. 75 李氏大藥廠控股有限公司
3. 76 12 19 2 5 二零一四年年報
3. 77 3937 李氏大藥廠控股有限公司
3. 78 二零一四年年報
3. 79 39 36 36 李氏大藥廠控股有限公司
3. 39 80 二零一四年年報
3. 81 李氏大藥廠控股有限公司
3. 82 二零一四年年報
3. 83 李氏大藥廠控股有限公司
3. 84 5% 1,500 二零一四年年報
3. 85 39 李氏大藥廠控股有限公司
3. 86 二零一四年年報
3. 87 李氏大藥廠控股有限公司
3. 5% 20% 20% 5% 33% 10% 50% 10% 25% 88 二零一四年年報
3. 89 李氏大藥廠控股有限公司
3. 90 二零一四年年報
3. 91 李氏大藥廠控股有限公司
3. 92 二零一四年年報
3. 93 39 41 李氏大藥廠控股有限公司
3. (a) (b) (c) 94 二零一四年年報
3. 95 李氏大藥廠控股有限公司
3. 30 120 96 二零一四年年報
3. 97 李氏大藥廠控股有限公司
3. 39 98 41 二零一四年年報
3. 99 37 李氏大藥廠控股有限公司
3. (a) 100 (i) (ii) (iii) 二零一四年年報
3. (b) (i) (ii) (iii) (iv) 101 (v) (vi) (a) (vii) (a)(i) 李氏大藥廠控股有限公司
4. 3 102 3,900,000 3,900,000 19 二零一四年年報
4. 38 103 302,835,000 5% 50% 5. 李氏大藥廠控股有限公司
6. 8 104 386,258 307,073 568,950 389,880 955,208 696,953 168,785 106,809 110,057 100,929 278,842 207,738 2,851 2,717 (50,201) (30,094) 231,492 180,361 (2,671) (1,853) 228,821 178,508 (668) (2,418) 228,153 176,090 (41,368) (27,087) 186,785 149,003 二零一四年年報
6. 3 105 236,748 226,132 685,511 503,542 922,259 729,674 447,121 435,981 1,369,380 1,165,655 118,746 98,890 172,100 163,719 290,846 262,609 79,667 50,988 370,513 313,597 李氏大藥廠控股有限公司
6. 106 17,845 9,705 1,525 1,813 19,370 11,518 197 9,191 4,443 9,191 4,640 35,918 69,357 90,884 152,699 126,802 222,056 5,649 6,094 5,649 6,094 二零一四年年報
6. 90% 793,265 556,559 576,115 609,096 1,369,380 1,165,655 198,933 175,882 171,580 137,715 370,513 313,597 107 7. 569,000,000389,900,000 95,900,00040,500,000 10% 8. 2,851 2,717 128 167 56 484 444 3,502 3,345 8,714 2,928 1,774 3,582 4,458 17,572 10,731 李氏大藥廠控股有限公司
9. 19,370 11,518 9,191 4,640 28,561 16,158 879 762 745 639 149,087 101,193 3,880 2,767 37,964 32,262 6,526 5,451 (3,296) (1,033) 1,436 3,308 264,967 172,216 10,092 108 10. 2,448 1,515 4 40 2,452 1,555 219 298 2,671 1,853 二零一四年年報
11. 62211 7832 161 109 2,285 942 17 6,832 10,076 6,537 3,144 1,296 17 12,961 17,418 12,765 4,343 1,790 17 3,450 9,600 6,392 Mauro Bove (i) 34 34 100 Marco Maria Brughera (ii) 96 96 68 96 96 78 94 94 73 320 9,772 4,028 51 23,243 37,414 26,013 66,000 (i) (ii) 李氏大藥廠控股有限公司
12. 11 2,752 2,539 17 15 2,769 2,554 110 1,000,000 1,000,0012,000,000 2 2 2 2 二零一四年年報
13. 25,875 14,763 13,153 11,278 1,233 (191) 40,261 25,850 1,107 1,237 111 41,368 27,087 16.5% 15% 25% 15% 25% 李氏大藥廠控股有限公司
13. 228,153 176,090 32,495 27,627 110 399 6,554 1,420 (3,460) (1,463) 1,233 (191) (7,218) (2,936) 14,681 4,174 (3,146) (1,516) (427) 119 112 41,368 27,087 64,000,00030,720,000 二零一四年年報
14. 0.027 0.023 14,687 12,367 0.066 0.052 35,952 27,989 50,639 40,356 113 6.6 5.2 李氏大藥廠控股有限公司
15. 192,830 150,467 41 (2,669) 192,871 147,798 114 542,871 529,656 9,780 11,706 6,905 4,996 559,556 546,358 48 Lee s Pharmaceutical International Limited 1.80 6,905,000 二零一四年年報
16. 21,967 2,911 29,078 13,578 5,525 94,348 167,407 581 1 769 203 94 2,497 4,145 (168) (2,707) 2,875 25,951 5,578 1,168 113,169 145,866 13,485 13,362 (26,847) (9,094) (3,909) (2,084) (257) (15,344) 115 26,771 2,912 62,544 20,150 6,530 183,167 302,074 (787) (1) (1,836) (385) (131) (4,994) (8,134) (38) 140 (102) 250 5,526 7,132 1,264 53,707 67,879 12,439 24,776 66 (37,281) (2,921) (8,548) (5,175) (276) (16,920) 35,502 3,123 82,602 21,686 7,663 194,323 344,899 11,424 2,013 14,954 8,364 1,838 38,593 302 396 140 37 875 (20) (527) 547 1,607 496 4,942 3,554 919 11,518 (5,875) (3,909) (2,084) (117) (11,985) 7,438 2,509 15,856 10,521 2,677 39,001 (192) (1) (452) (156) (62) (863) (23) 23 1,776 233 11,781 4,408 1,172 19,370 (2,348) (7,967) (5,129) (15,444) 6,674 2,718 19,218 9,667 3,787 42,064 28,828 405 63,384 12,019 3,876 194,323 302,835 19,333 403 46,688 9,629 3,853 183,167 263,073 李氏大藥廠控股有限公司
16. 544,338 17. 67,227 71,501 138,728 1,643 1,643 36,708 39,482 76,190 (1,950) (4,144) (6,094) 101,985 108,482 210,467 (62) (2,139) (2,201) 20,753 38,170 58,923 (5,649) (5,649) 116 122,676 138,864 261,540 6,824 4,748 11,572 126 126 2,376 2,264 4,640 9,200 7,138 16,338 (207) (207) 6,984 2,207 9,191 16,184 9,138 25,322 106,492 129,726 236,218 92,785 101,344 194,129 二零一四年年報
17. 9,191 4,443 197 9,191 4,640 117 3,840 (3,840) 李氏大藥廠控股有限公司
18. 15,546 15,481 (410) 410 15,136 15,891 (326) (345) 14,810 15,546 (324) (333) 14,486 15,213 118 19. 3,900 3,900 10%10% 二零一四年年報
20. 36,949 36,949 (3,086) (2,418) 33,863 34,531 119 86,311 39.65% 39.65% 李氏大藥廠控股有限公司
20. 6,094 6,367 72,050 74,793 (38,739) (40,002) (24) (93) 120 17,582 26 (125) (6,099) (1,684) (6,099) (1,684) (6,099) 39,381 41,065 (39.65%) 15,614 16,282 18,249 18,249 33,863 34,531 二零一四年年報
21. 5,323 5,156 3.28 3.28 22. 121 1 31,233 2 11,534 7,882 42,767 7,882 1. 2. 7,882,000 1,774,000 李氏大藥廠控股有限公司
23. 15,972 15,505 22,036 17,437 100,881 84,939 138,889 117,881 24. 122 100,346 82,230 (564) (3,910) 99,782 78,320 30 120 365100% 365 180 二零一四年年報
24. 0 30 35,640 38,656 31 120 57,433 23,802 121 180 4,571 4,362 181 365 2,004 4,404 365 134 7,096 99,782 78,320 123 22,116,48221,592,322 5% 1 180 18,520 21,491 181 365 521 1,655 19,041 23,146 李氏大藥廠控股有限公司
24. 3,910 4,908 (50) 35 (3,296) (1,033) 564 3,910 124 181 365 521 1,655 365 43 2,255 564 3,910 25. 47(c) 二零一四年年報
26. 0.01% 1.06% 0.01% 1.06% 0.25% 0.35% 0.28% 0.70% 3.6% 1.10% 3.05% 2,000,0002,000,000 27. 125 0 90 42,227 16,906 91 180 19,583 181 365 10 365 12 4 42,249 36,493 90 李氏大藥廠控股有限公司
28. 3,371 7,923 3,210 3,371 11,133 (7,923) 3,371 3,210 126 29. 10,092 10,092 10,092 41 二零一四年年報
29. 4,000,000 1.341 8,000,000 1.311 41 44 127 30. (1)(2) 52,269 69,468 (3) 16,207 17,157 16,245 16,154 19,817 36,157 52,269 69,468 (1) 3% 4% 3% 4%0.875% 2.75% (2) 5 (3) 李氏大藥廠控股有限公司
31. 8.99% 5.52% 8.99% 154 150 154 150 (4) 128 150 150 (150) 二零一四年年報
32. 391 12,424 400 13,215 199 10 209 (279) 1,926 (410) 1,237 129 112 14,549 14,661 (246) (246) (159) 1,266 1,107 (47) 15,569 15,522 250,000,000204,000,000 李氏大藥廠控股有限公司
33. 0.05 1,000,000,000 1,000,000,000 50,000 50,000 538,245,604 521,104,437 26,912 26,055 6,475,000 1,974,500 324 99 15,166,667 758 544,720,604 538,245,604 27,236 26,912 130 二零一四年年報
34. 292,326 9,200 5,363 46,005 352,894 3,839 3,839 8,870 (1,472) 7,398 52,619 52,619 3,319 3,319 131 3,319 52,619 55,938 (28,251) (28,251) (14,687) (14,687) 301,196 9,200 7,730 3,319 55,686 377,131 260,656 9,200 3,290 22,309 295,455 2,727 2,727 5,300 (654) 4,646 26,370 26,370 56,934 56,934 (20,871) (20,871) (12,367) (12,367) 292,326 9,200 5,363 46,005 352,894 377,130,000 352,890,000 李氏大藥廠控股有限公司
34. 35. 66,039 14 66,053 36 966 966 37 4 4 3,518 3,518 (6,045) (6,045) 12 12 18 18 132 64,494 32 64,526 二零一四年年報
35. 11,122 1 11,123 56,380 56,380 (1,464) (1,464) 1 1 13 13 66,039 14 66,053 133 33% 43.74% 43.74% 35% 211,200 36. 24,00030,000 33% 996,000 37. 4,200 4,200 35% 65% 28,000 4,000 李氏大藥廠控股有限公司
38. 5% 1,5001,250 494,517332,033 114,245 72,311 134 Messrs. Ascent Partners Valuation Service Limited 二零一四年年報
39. 18,554,500 23,679,500 3.4% 4.4% 10% 1% 135 10% 10% 10% 30% (i) (ii) (iii) 李氏大藥廠控股有限公司
39. 500,000 500,000 0.159 500,000 500,000 0.175 448,000 448,000 1.076 997,500 997,500 3.750 469,000 469,000 2.666 319,000 (319,000) 4.996 1,042,000 1,042,000 4.930 1,614,000 1,614,000 7.300 600,000 600,000 10.340 2,160,000 (2,160,000) 0.218 1,685,000 (1,685,000) 0.159 320,000 320,000 0.492 1,995,000 (1,335,000) 660,000 2.200 6,040,000 (426,000) 5,614,000 4.996 300,000 300,000 5.620 2,040,000 2,040,000 7.300 750,000 750,000 10.340 500,000 500,000 0.175 2,000,000 2,000,000 0.492 500,000 (500,000) 0.383 250,000 (50,000) 200,000 3.750 136 23,679,500 1,350,000 (6,475,000) 18,554,500 12,467,500 3.311 10.340 1.201 4.558 8.405 二零一四年年報
137 李氏大藥廠控股有限公司 39. (i) 50% (ii) 0.218 (i) 50% (ii) 0.159 (i) 50% (ii) 0.175 (i) 50% (ii) 0.492
138 二零一四年年報 39. (i) 50% 0.383 (ii) (i) 50% (ii) 1.076 (i) 50% (ii) 2.200 (i) 50% (ii) 3.750
39. (i) 50% (ii) 2.666 139 (i) (ii) 259,500 259,500 4.996 (iii) 1,160,000 (iv) 2,230,000 (v) 2,650,000 (i) (ii) 50% 4.930 李氏大藥廠控股有限公司
140 二零一四年年報 39. (i) 50% 5.620 (ii) (i) 1,614,000 50% 7.300 (ii) 669,000 (iii) 669,000 (iv) 702,000 (i) 600,000 50% 50% 10.340 (ii) 250,000 (iii) 250,000 (iv) 250,000
39. 1,291,500 1,291,500 857,000 (319,000) 538,000 2,441,000 2,441,000 Mauro Bove 1,300,000 600,000 1,900,000 141 5,889,500 600,000 (319,000) 6,170,500 14,540,000 750,000 (5,606,000) 9,684,000 3,250,000 (550,000) 2,700,000 23,679,500 1,350,000 (6,475,000) 18,554,500 李氏大藥廠控股有限公司
39. 5,583,000 Black-Scholes 1. 10.340 2. 42.32% 50.17% 3. 4. 0.87% 1.24% 5. 1.51% 1.65% Messrs. Ascent Partners Valuation Service Limited Black-Scholes Black- Scholes 142 二零一四年年報
39. 440,000 440,000 3.26% 3.26% 500,000 30% 143 133,000 133,000 a 1.628 267,000 267,000 b 1.628 40,000 40,000 1.628 440,000 440,000 40,000 1.628 1.628 a. Rostafuroxin Istaroxime b. Rostafuroxin Istaroxime 李氏大藥廠控股有限公司
39. (i) 133,000Rostafuroxin Istaroxime 1.628 (i) 267,000Rostafuroxin Istaroxime 1.628 (i) 40,000 1.628 144 3,880,0002,767,000 40. 二零一四年年報
40. 1 52,269 69,618 (392,912) (379,062) (340,643) (309,444) 2 934,341 786,005 145 (1) 30 31 (2) 41. 李氏大藥廠控股有限公司
41. 146 327,707 227,860 161,818 126,342 137,707 204,096 4,021 5,246 25,193 1,980 48,837 46,832 343 368 40 490,950 434,344 213,726 178,420 二零一四年年報
41. 5% 5% 147 1,301 3,051 6,994 2,025 6,684 9,942 (1,135) (2,243) 17 18 2 6,852 10,750 7,011 2,043 李氏大藥廠控股有限公司
41. 5%5% 1,562,000 148 46 二零一四年年報
41. 149 7 24 10% 5% 李氏大藥廠控股有限公司
41. 225,114 225,114 562 2,809 3,371 1 52,269 52,569 2 6,000 6,000 150 283,945 2,809 286,754 181,858 181,858 21 42 87 150 2,038 5,885 3,210 11,133 1 69,468 69,468 253,385 42 5,972 3,210 262,609 二零一四年年報
41. 1. 1 2. 151 17,493 34,722 52,083 104,298 (20,548) (41,096) (61,179) (122,823) (3,055) (6,374) (9,096) (18,525) 李氏大藥廠控股有限公司
41. 31,2330,000 10,092,000 Monte Carlo 6.23% 152 46,812,000 23,569,000 3.8% 2.12% 5.08% AAA 3.51% to 7.24% 二零一四年年報
41. 23,569 23,569 10,092 23,243 33,335 10,092 46,812 56,904 153 42. 6,526 5,451 6,167 3,369 6,548 4,269 12,715 7,638 李氏大藥廠控股有限公司
43. 14,793 40,862 15,049 10,178 15,308 25,334 28,096 91,167 58,453 44. 12,000,000 154 45. 2,000,000 544,338 46. 101,000 82,819 6,000 6,000 6,000 107,000 82,819 二零一四年年報
47. (a) Sigma-Tau 155 Sigma-Tau (1) 93,565 99,437 Sigma-Tau (1) 2,941 3,887 96,506 103,324 1. Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Sigma-Tau 李氏大藥廠控股有限公司
47. (b) 14,171 13,335 1,204 743 23,243 12,678 38,618 26,755 156 (c) 4 8,000,000 4 4,032,080 4 4,000,000 4 4,000,000 8 484,000444,000 二零一四年年報
47. (d) Sigma-Tau Sigma-Tau Sigma-Tau 240,000 2,299,000 (e) 10,500 457,800 3,550,000 157 48. 1 1 357,234 340,395 357,235 340,396 李氏大藥廠控股有限公司
48. Lee s Pharmaceutical 1 100% 100% International Limited 1,000,000 100% 100% 18,400,000 100% 100% 2,000,000 100% 100% 158 30,000 65% 100% 16,000,000 100% 100% 二零一四年年報
48. 1 100% 100% 1,500,000 100% 67% 75,952 56.26% 56.26% A-1 19,048 A-2 12,000 B 28,000 1,500,000 56.26% 56.26% 159 500,000 56.26% 1 1. 李氏大藥廠控股有限公司
48. 43.74% 43.74% (5,272) (1,160) 61,008 66,262 160 70,910 99,815 72,668 55,067 (4,100) (3,391) 139,478 85,229 61,008 66,262 二零一四年年報
48. 5,221 410 (17,274) (3,621) (12,053) (3,211) 161 (6,781) (2,051) (5,272) (1,160) (12,053) (3,211) (6,781) (2,051) (5,272) (1,160) (12,053) (3,211) 李氏大藥廠控股有限公司
48. (14,373) (21) (21,244) (37,650) 99,654 162 (35,617) 61,983 49. 11,660 6,894,239 48,878 56.63% 2,000,000 261,239 B 2,000,0004 二零一四年年報