DcR3.Fc DcR3 FasL LIGHT TL1A Pitti 1998 FasL LIGHT T FasL LIGHT T T β DcR3 T IgG1 Fc baculovirus Zhang 2001 72
recombinant DcR3 IgG1 Fc DcR3.Fc LIGHT T DcR3.Fc DcR3 DcR3.Fc NOD T NOD DcR3.Fc NOD NOD FasL LIGHT DcR3.Fc DcR3.Fc Ligand reverse signal DcR3.Fc DcR3.Fc 73
MHC class II, CD40, CD54, CD80 CD11c CD86 CD80 CD86 T IFN- γ IL-10 Freedman 1991 Ding 1993 DcR3.Fc CD86 CD80 CD80 CD86 CD80 CD86 T IL-2 IFN- γ CD86 IL-4 CD80 IFN- γ DcR3.Fc T T IFN-γ DcR3.Fc T IL-4 Hsu 2002 NOD IL-4 DcR3.Fc T IFN-γ 74
DcR3.Fc T IL-4 BALB/c DcR3.Fc T IL-4 IFN-γ DcR3.Fc T Th2 DcR3.Fc Th2 T DcR3.Fc T DcR3.Fc NODscid NOD NODscid DcR3.Fc T DcR3 Th2 DcR3.Fc 75
DcR3.Fc 8 DcR3.Fc DcR3.Fc 7 % p38 MAP kinase DcR3.Fc p38 MAP kinase β p38 MAP kinase p38 MAP kinase Puig-Kröger 2001 DcR3.Fc DcR3.Fc p38 MAP kinase DcR3.Fc ERK kinase p38 MAP kinase MAPK kinase ERK kinase DcR3.Fc ERK kinase 76
ERK kinase DcR3.Fc Rescigno 1998 LPS fibroblast supernatant GM-CSF ERK kinase Puig-Kröger 2001 TNF-α ERK kinase PD98059 IL-12 DcR3.Fc ERK kinase IL-12 NF-kB NF-kB NF-kB NF-kB NF-kB MHC 77
Rescigno 1998 DcR3.Fc NF-kB DcR3.Fc DcR3.Fc β IL-17 precusor DcR3.Fc IL-17 precursor IL-17 T Rouvier 1993 IL-17 proinflammatory cytokine -6-8 prostaglandin E2 Yao 1995 Fossiez 1996 DcR3.Fc IL-17 DcR3.Fc vimentin, GADPH, cyclin-dependent kinase 6, signal-induced proliferation-associated gene 1 Ras-GTPase-activating protein SH3 domain-binding protein 78
DcR3.Fc DcR3.Fc DcR3.Fc 1 GM-CSF IL-4 DcR3.Fc DcR3.Fc B220 5 % B220 5 % B 2 DcR3.Fc 3 10 % B B GM-CSF IL-4 B DcR3.Fc 5 % B220 DcR3.Fc B DcR3.Fc T 79
T T NOD T Steinman 2003 DcR3.Fc T T IFN-γ Th1 Th2 IL-1 TNF-α IFN-α proinflammatory cytokine IFN-γ IL-2 IL-12 Th1 IL-4 IL-10 Th2 Rabinovitch 1998 Adorini 2002 NOD 1 80
2 3 NOD rat insulin promoter β IL-2 IL-10 β IL-10 ICAM-1 T β TNF-α NOD TNF-α T Th1 IL-4 TGF-β IL-12 p40 homodimer IL-12 β NOD IL-12 p40 IFN-γ NOD NOD 81
Th1 NOD NOD IL-4 IL-10 NOD IL-2 IL-4 IL-10 NOD TNF-α NOD 3 TNF-α 4 IL-12 DcR3 CD86 CD80 T T IFN-γ IL-10 T Wakkach 2003 Th2 82
DcR3 DcR3 DcR3 β β DcR3 β 1 2 Th1 3 DcR3 β β DcR3 T FasL LIGHT DcR3 β IL-10 TGF-β 83
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