01011 490 1.3%38,580 37.0%3,6505,000 3.21 2.84 1
385,789 380,903 (229,046) (200,700) 156,743 180,203 4 7,891 1,030 5 (757) 1,887 (72,939) (89,929) (28,464) (24,531) 970 (6,304) (1,396) (5,175) 62,048 57,181 (8,014) (19,020) 6 54,034 38,161 7 (3,966) (1,671) 50,068 36,490 50,068 36,490 50,068 36,490 8 3.21 2.84 3.16 2.84 2
50,068 36,490 4,356 (2,290) 54,424 34,200 54,424 34,200 54,424 34,200 3
297,640 300,501 43,527 43,964 341,167 344,465 126,284 133,425 87,374 87,745 554,825 565,635 131,226 174,834 9 550,201 306,460 23,389 210,104 327,995 891,531 832,678 10 161,672 215,696 11 266,984 141,170 120,000 20,752 18,724 449,408 495,590 442,123 337,088 4
996,948 902,723 11 57,000 939,948 902,723 1 1 927,587 890,362 927,588 890,363 12,360 12,360 939,948 902,723 5
1. 34 2. 3. 6
(a) 266,821 283,417 118,968 97,486 385,789 380,903 (183,697) (158,157) (45,349) (42,543) (229,046) (200,700) 83,124 125,260 73,619 54,943 156,743 180,203 8,638 52,356 63,669 32,219 700 504 73,007 85,079 7
(b) 385,789 380,903 73,007 85,079 (17,667) (19,336) 7,891 1,030 (757) 1,887 (8,014) (19,020) 970 (6,304) (1,396) (5,175) 54,034 38,161 4. 3,945 982 1,665 3 2,281 45 7,891 1,030 5. (155) (31) (602) 1,918 (757) 1,887 8
6. 9,589 6,649 418 418 115 1,115 70 21,472 75 10,841 3,775 2,036 229,019 188,350 (3,153) (3,406) (43) (9,122) 7. 3,595 1,671 371 3,966 1,671 9
(i) (ii) 16.5%16.5% 25%25% 15%15% 8. (a) 50,068,00036,490,000 1,557,997,8001,283,922,000 (b) 50,068,00036,490,0001,582,814,000 1,285,999,000 9. 980,350 856,831 (616,930) (620,008) 363,420 236,823 186,781 69,637 550,201 306,460 10
30240 308,400 198,341 20,241 6,707 34,779 31,775 363,420 236,823 10. 26,053 15,338 7,840 26,053 23,178 11,760 9,859 123,859 182,659 161,672 215,696 16,889 18,031 5,993 3,592 1,812 135 1,359 1,420 26,053 23,178 11
11. 266,984 141,170 57,000 323,984 141,170 24,256 24,035 12. 13. (a) (i) Novartis AGNovartis Pharma AG (a) (b) (ii) 145,000,000 1,131,000,000 12
1. 131 490 1.3%38,58038,090 6,200 5,720 5,0003,650 13
2. 15020 100 (MDS) 50 863 13120 14
(MDS) 863 -- NCCN 15
3. 1,6605.9%26,680 28,340 6,81035.1%26,210 19,400 2,15022.0% 11,9009,750 3,30061.6% 8,6605,360 1,21039.7%1,840 3,050 16
4. 17
5. 432283 1,9102,630 18
6. 000 (%) 000 (%) 52 3,472.6 179,483 46.5% 30 4,005.8 121,297 31.8% 32 2,581.3 82,602 21.4% 28 2,596.0 72,688 19.1% 1,751 41.5 72,670 19.1% 56 84.8 4,736 1.2% 331 50.6 16,762 4.4% 140 1,911.8 266,821 69.1% 2,140 132.4 283,417 74.4% 3,220 26.9 86,643 22.5% 2,608 20.5 53,586 14.1% 14,817 1.2 18,417 4.8% 22,441 1.4 30,539 8.0% 7,250 1.9 13,908 3.6% 10,054 1.3 13,361 3.5% 25,287 4.7 118,968 30.9% 35,103 2.8 97,486 25.6% 25,427 1,916.5 385,789 100% 37,244 135.2 380,903 100% 1,6605.9%26,680 69.1%28,340 74.4% 6,81035.1% 26,210 98.2%19,40068.4% 30,30021,40070.7% 4,005.8 533.213.3%3,472.6 8,2602,581.3 19
2,15022.0%11,900 30.9%9,750 25.6% 2,608,000 612,00023.4% 20.56.431.2% 26.9 2,83014.1% 22,90020,070 (%) (%) 83,473 31.8% 115,695 59.6% 7,912 10.9% (349) 1,653 9.9% 83,124 31.2% 125,260 44.2% 64,558 74.5% 38,887 72.6% 9,868 53.6% 16,150 52.9% (807) (94) 73,619 61.9% 54,943 56.4% 156,743 40.6% 180,203 47.3% 20
2,35013.0%15,670 18,020 6.740.6%47.3% 1,14012.0%8,370 9,510 7,3008,510 (%) (%) 8,638 3.2% 52,356 18.4% 63,669 53.5% 32,219 33.0% 700 504 73,007 18.9% 85,079 22.3% 21
1,10057.9%800 1,900 400 170 5,000 3,650 5,130 4,800 22
50,068 36,490 1,396 5,175 (970) 6,304 602 155 51,251 47,969 1,557,998 1,283,922 1,582,814 1,285,999 3.21 2.84 3.16 2.84 3.29 3.74 3.24 3.73 23
29020.8% 1,6701,380 7. 60 190 24
(323,984) (261,170) 210,104 351,384 (113,880) 90,214 266,984 261,170 57,000 323,984 261,170 32,400 26,1201,1001,120 3.2% 31,30013,0004.3%5.8% 120,000,0008.5% 25
323,984 261,170 1,446,356 1,398,313 22.4% 18.7% 2,340 14,900 2,430 2,400 4,750 198 1,299,715 1,304,465 198 26
2,898 5,525 3,376 2,898 8,901 (i) Novartis AGNovartis Pharma AG (a) (b) (ii) 27
145,000,000 1,131,000,000 Paget 35 28
8. 9. A.2.1 29
37.5% 10. 11. 12. 30