:,, : : ( 800 : 200433) : 7871092 1/ 16 : 10.75 : 260 520 1998 6 1 1998 6 1 :12 000 ISBN 7-81060-013-3/ R012 : 22.00
,,,,,,,,,,, 12, 4,, WH O, 270,, ( ),,,,,,,,,,,,,,,,,, 1998 6 8
1 11 15 20 27 31 35 55 59 63 80 95 105 113 116 120 124 129 AIDS 135 138 149 160
986 25 41,, 9 139 1996, (),, 25, 1986 9 139, 1996 18 085, 10 1., K O H, 2. (1 ) ( g) : 20 10 181 000 ml, 10 min, 0. 05 mg/ ml 0. 5 mg/ ml, (2 ) 80 ( g) : 10188 0 10 ml 1 000 ml, 10 min, (3 ) ( g ) : 80 NaNO3 4 H2 O 0. 01 K2 H PO4 3MgSO4 7 H2 O 0. 5 KCl 0. 5 FeSO4 1 131 000 ml, (4 ) / ( g) : 4010 0. 1 18 25 80 100. 051 000 ml, 40 ml,,, 121, 15 min,, / 3.,,, Campbell, Hoogs 25 41, 9 139 ( 1986 ) 18 085( 1996 ), 14, 10 1 1
1986 1996 10 1 86 96 2 86 96 3 86 96 4 86 96 5 86 96 6 86 96 7 86 96 8 86 96 9 86 96 10 86 96 : ( T r) = ; ( Mc) = ; ( T v) = ; ( Mg ) = ; ( ) ( Tm ) = ; ( Mf) = ; ( T t ) = ; ( P o) = ; ( T ve) = ; ( Ca) = ; ( T s ) = ; ( Ef ) = 4 Tr Ts Mf T m Ef Tv T t T c Mc Mg Tve Tmn Te Tsi Ma Mn Po Total 19491985 N 7170 5483 3154 1753 551 2116 275 203 578 102 31 32 5 4 2 21459 % 33.4 25.6 14.7 8.2 2.6 9.9 1.3 1.0 2.7 0.5 0.1 0.2 1986 N 4150 200 200 1744 262 583 156 4 422 139 2 2 580 9139 % 45.5 2.2 2.2 19.1 2.8 6.4 1.7 4.6 1.5 6.9 1996 N 6253 15 23 1911 233 57 86 2 606 52 47 34 9 741 9719 % 34.8 10.6 1.2 0.3 0.5 3.4 0.2 0.3 0.1 40 8
1 986 1 1 12 31 1996 1 1 12 31 % % 1. 45. 4 1. 34. 5 2. 19. 1 2. 19. 6 3. 6. 4 3. 10. 6 4. 6. 3 4. 5. 6 5. 5. 0 5. 4. 2 6. 4. 6 6. 4. 1 7. 2. 8 7. 3. 4 8. 2. 2 8. 1. 6 9. 2. 2 9. 1. 4 1986 10. 1. 7 11. 4. 3 1996 10. 1. 2 11. 14. 8 1 1986 1996 10,1986 1996,, 1986 45. 4% 1996 34. 5 % 1986 2 ( ), 1996 3, 19. 1% 10. 6% 1986 5 1996 1986 5 2, 1986 5. 0% 19. 6 %,,,1986 27, 1996 108, 10,,, 1996, ( ), 1986 2 : 1986 5 1996 2, 1986 1996 8 4 5, 1996,, 1996 7. 2%, 2,,, 21, 9
, 1996 40, 1986, 21,, 1986 1996,,,, 1986 45. 5% 1996 34. 8%, 1/ 4 2, 1986 19. 1% 10. 1%, 1/ 2,,,, 1986 5. 0% 25. 1 % 2,,, 10,,, 21,, :,, ( ) 10
0, 40,, 1990 1980 1. 9,, 29% ( 17% ),,,,,,, ( ),, ( ),, ( ) ( LA ), ( CF ), ( ELISA), LA ( 5 min ), (100 % ), (99% ), ( ),,,, ( pronase),,,,, ELISA,,,,,,, LA( 6 ng/ ml, LA 35 ng/ ml), (3 d 5 d), (59 16 400, LA 1800 ),,, ( FA), ( ),,,, 11
,,,, (), ( ),, LA CIE, 14,, 4,, ( ), (),,, ELISA Manan (48 kd), 100%, ( 71. 8% ), > 100 ng/ ml, ( 75 % 85% ) 50%,,,,, ELISA,, ph7. 2 EDTA 1 ml 3 min,, 1 300 g 30 min, 1 ng/ ml,,,, : ( 13 ) - -D,, -,, ( 1 4 ) -, (13) - - ( 16 )- - ( 13 )- -, (13) - -D, 6 800 -G,, 4 pg/ nl,,,, 2 h, 405 m, 100%,, 1 h 1. 12 ID CF CIE ELISA P H A(),
, ID, 1520,, ( 100 % ) ; ;, C-, 90 %, 70%,, 7, IgE IgG(RIE) (80% 90% ) ;,,,, (, catalase, chymotrysin ), 88% 94 % 2. - -, ConA, ELISA, 1 ng/ ml, 100 ng/ ml,,, RIA, 78%, 80 %, 28 ng/ ml, EDTA, > 45 kd (11. 44 kd), LA, 95%, 99 %,, LA,,,,,, ( ),, ( F A ),, 100%, CF LA 90 %, CF, 23 90 %, LA,,,116, 132,, 95% 1 132, 4,,, 12% 27%, 2 ID CIE,,, nm, m,, n, 13
( ), T P LA ID( CIE) CF ELISA () (), 23 90%, 46 ; LA, ( 6% 10 % ), ; CF 4,,, CF CF ;, CF, HSHL F, ELISA, IgM IgG, 96. 7%, 92. 6 % CD CF, (50% ),, A B 2, A A ( EIA ),,,, DNA,, RF LP, Southern, 100%,, ( PCR ),, 115 ( 110 pg DN A ) ( )PCR,,,,,,, PCR,, CP L1 CPR4 DNA 343 bp DN A Southern, 100 fg, 1 pg PCR, DN A ( ) 4 h,, ( ) 14
,,,,,,,,,, 30, 35,, 1/ 3,,, 1.,,,,, : A A, B 14- C (1 ) A, ( naftifine)( ter binafine),,, 2, P450,, P450,, P450,, 2,,,,,, (2 ) P450 B,, C-14 SDZ89-485 BA YR384 H 39340 PR988-399FB ICI195 SDZ89-485, P450, 14-,, 14-15
Ballard P450, P450 4 P450, 14- P450, 14 C, TMS /, 4, 14-,, Ryder SDZ89-485, 14-, 24-, C- 14 C-4 14-, SDZ89-485 P450,,,,,,,, Moline 100,,,,, Van Et ten B( AmB), AmB,,, 2, 2 ( 3) 14-7, 8- C, (amorolfine), 14-7, 8-,,,,,, 14, C-14,,, 5%,,,, 2., AmB,,,, AmB, AmB, Gruda 4 AmB, 4 AmB 16
AmB,,, AmB [ ( C16 ) > ( C14 ) > ( C12 ) > ( C10 ) ], AmB : AmB, AmB,,, AmB 3.,,, 1. - ( Mn ) - ( MmP) BMY- 28864 P radimicin A, A B C3,, BMY-28864 ph,,, MIC 1.612.5 g/ ml, AmB 98%, AmB 299/ 300, ph 5.08.5,, Mn MnP, Mn,,,,, Ca 2 +, Ca 2 +, 2.,,, 2 2,, D (Z X), Cabib 2 2, 2 Mg 2 +,,, Ca 2 +, 2, Z, 20g/ ml, D,, Ca 2 + Z, D, 2 N-, Mg 2 +,, I, 2, Km, Z,, D, Z,,, 3. - -(1,3 )( 67 % ) -( 1, 6)(14% ) - 48% 60%, -(1,3 )-,, -( 1, 3 ) 17
B A, ( LY-121019), -(1,3 ), 0.025 % ( W-1 ), W-1, Km, B,,, MIC 5.0 g/ ml,, 10 g/ ml 3 h,,,,,,, 0.6 g/ l, CF U/ g 90% AmB, 100 % Denning,,,,,, AmB 95%,, 4. 6-,, F MDP, 6-, MnP,,, 5- ( 5- FC ),, DN A 5- FC,, AmB 5-FC 5- FC : 5- FC 5- ( 5-F U), 5- FU 5- (5-FdUMP ), dump, dump DNA ( dt MP ), DNA 5-FdUMP 5- FU DP, RN A, DN A, m RNA, 5- FC,, 5- FC, ( PAF E), 2, P AF E,, 18