t07aplp - PDF 免费下载

Hansoh Pharmaceutical Group Company Limited (a) (b) (c) (d) (e) (f) (g) (h) (i) (j) 1933 (k)

[Logo] Hansoh Pharmaceutical Group Company Limited [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 0.00001 [ ] [ ] [ ] 32 342C [ ] [ ] [ ] [ ] [ ][ ] [ ][ ] [ ][ ][ ] [ ] [ ] [ ][ ] [ ] [ ][ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] (www.hkexnews.hk) [ ] (www.hansoh.cn )[ ][ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] (i) 144A (ii) S [ ] [ ]

[ ] ii

[ ] iii

[ ] iv

[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ][ ] [ ] [ ] [ ] [ ] [ ] www.hansoh.cn...... ii v... 1... 11... 20... 27... 29... 77 [ ]... 81 [ ]... 85... 88 v

... 90... 102... 127... 143... 207... 255... 268... 278... 281 [ ]... 282 [ ]... 284 [ ]... 293 [ ]... 304... [I-1]... [II-1]... [III-1]... [IV-1]... [V-1] vi

[ ] [ ] [ ] (i) (ii) (iii) (iv) 2017 62.1% 2013 2017 13 2015 2016 2017 2018 6 30 82.3%83.4%85.7% 89.8% 1.1 2018 2020 15 1.1 2015 2016 2017 50.452 54.330 61.855 2016 2017 7.7% 13.9% 2018 6 30 37.742 2017 29.749 26.9% 2015 2016 2017 14.486 14.760 15.955 2016 2017 1.9% 8.1% 2018 6 30 10.423 2017 7.761 34.3% 2015 2016 2017 2018 6 30 92.6%92.7% 92.6% 93.4% 28.7%27.2%25.8% 27.6% 1

2011 1.1 FDA 2

Frost & Sullivan 2017 9.1% 2014 2015 2016 2017 2018 6 30 14.639 14.733 16.817 9.833 Frost & Sullivan 2017 2.5% 2015 2016 2017 2018 6 30 17.614 20.269 24.437 16.740 Frost & Sullivan 2017 11.7% 2015 2016 2017 2018 6 30 6.722 8.474 9.862 6.062 Frost & Sullivan 2017 2015 2016 2017 2018 6 30 4.821 4.796 4.803 2.215 3

2015 2016 2017 2018 6 30 5.762 5.305 5.281 2.520 2015 2016 2017 2018 6 30 89.4 75.4 65.6 37.1 1.1 1.1 2018 2020 30 15 1.1 20 2011 1.1 2002 1.1 1.1 CMC 1.1 2016 4

4,200 1,900 5,000 2015 2016 2017 12 31 2017 2018 6 30 5

12 31 6 30 2015 2016 2017 2017 2018 % % % % %... 5,045,174 100.0 5,432,960 100.0 6,185,537 100.0 2,974,855 100.0 3,774,196 100.0... (374,573) (7.4) (397,279) (7.3) (455,171) (7.4) (213,473) (7.2) (250,192) (6.6)... 4,670,601 92.6 5,035,681 92.7 5,730,366 92.6 2,761,382 92.8 3,524,004 93.4... 81,491 1.6 85,811 1.6 93,230 1.5 32,169 1.1 35,944 1.0... (2,240,230) (44.4) (2,378,040) (43.8) (2,704,200) (43.7) (1,308,407) (44.0) (1,558,557) (41.3)... (454,719) (9.0) (537,972) (9.9) (614,075) (9.9) (284,056) (9.5) (368,292) (9.8)... (408,980) (8.1) (403,065) (7.4) (575,544) (9.3) (256,126) (8.6) (362,609) (9.6)... 42,076 0.8 5,274 0.1 3,014 0.0 290 0.0 7,541 0.2... (6) (0.0) (3,411) (0.1)... 1,690,233 33.5 1,804,278 33.2 1,932,791 31.2 945,252 31.8 1,278,031 33.9... (241,642) (4.8) (328,244) (6.0) (337,318) (5.5) (169,146) (5.7) (235,724) (6.2)... 1,448,591 28.7 1,476,034 27.2 1,595,473 25.8 776,106 26.1 1,042,307 27.6 12 31 6 30 2015 2016 2017 2018... 5,185,194 3,463,699 4,417,867 5,700,773... 6,307,911 1,811,964 1,227,674 1,497,400... (1,122,717) 1,651,735 3,190,193 4,203,373... 1,245,285 1,357,252 1,456,181 1,542,492... 34,649 127,684 174,038 6 30 12 31 12 31 6 30 2015 2016 2017 2018 (1)... 0.8 1.9 3.6 3.8 (%) (2)... 22.5 26.2 29.8 31.8 (%) (3)... 28.7 27.2 25.8 27.6 6

(1) (2) 100% 2018 6 30 (3) [ ] Stellar Infinity [ ] [ ] Stellar Infinity Sunrise Investment Sunrise Investment Sunrise Sunrise Sunrise Stellar Infinity Sunrise Investment [ ] 2018 7 1.1 2018 7 31 40 2018 6 30 2018 6 30 [ ] [ ] [ ] [ ] D.[ ] 7

[ ] [ ] [ ] [ ] [ ] [ ][ ] [ ] [ ] [ ] [ ] [ ] 2018 12 31 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 8

[ ][ ][ ] [ ] [ ] (i) [ ] [ ] (ii) [ ] [ ] [ ] [ ] [ ] [ ] [ ] (i) [ ] (ii) [ ] (iii) [ ] 2018 2020 15 (iv) [ ] [ ] [ ] [ ] [ ] 2015 2016 2017 2018 6 30 6.442 34.746 4.041 2015 2016 2017 2018 6 30 40.230 2018 7 31 2018 6 30 40 9

[ ] [ ] (i) (ii) (iii) [ ] [ ] 10

[ ] Apex Medical Apex Medical Company Ltd. 2015 12 2 [ ] [ ] [ ] 1961 2018 [ ] 11

[ ] 2018 4 2 622 32 2015 12 2 Stellar InfinitySunrise Investment 2008 1 1 Fortune Peak Fortune Peak Company Ltd. 2015 12 2 12

Frost & Sullivan Frost & Sullivan [ ] Frost & Sullivan [ ] [ ] 2015 12 3 Hillhouse SuperX Holdings Limited 2015 7 2 [ ] 3% [ ] [ ] 13

[ ] [ ] [ ] 14

[ ] 1995 7 26 2018 4 10 2006 7 19 [ ] 2011 12 31 2018 8 31 2015 12 17 [ ] 15

[ ] [ ] [ ] [ ] 16

[ ] [ ] [ ] 300 [ ] 2016 2 19 300 0.01 300 0.01 [ ] 144A S S [ ] 144A 144A 17

571 2011 10 13 2009 11 5 0.00001 [ ] Stellar Infinity Stellar Infinity Company Ltd. 2015 12 14 Sunrise Investment 100% Sunrise Investment Sunrise Investment Advisors Limited 2016 1 29 Sunrise 100% 18

Sunrise Sunrise 2016 1 28 Sunrise Sunrise Sunrise Harmonia Holding Investing (PTC) Limited 2015 2016 2017 12 31 2018 6 30 [ ] 1933 [ ] 19

API Xa Bcr-Abl 9 ABL 22 BCR (CML) (ALL) (AML) 20

II 1.1 CDA 1.1 1.1 2016 3 4 1.1 1 1.1 cgmp 21

100 100 500 500 EDQM EGFR 22

Bcr-Abl TK GMP HS-10234 HS-10296 EGFR 23

KFDA (Korea Food and Drug Administration) 24

D2/5-HT2 PMDA GLP-1 II 5-HT4 25

Xa TKITK FDA -IV(DPP-IV) II 26

[ ] [ ] 27 2015 2016 2017 2018 6 30 82.3%83.4%85.7% 89.8% 29

2015 6 1 2015 5 2015 6 1 31

2015 7 2015 7 22 117 (2015)) 1622 2015 7 31 140 (2015)) 2015 11 11 230 (2015)) 32

2016 3 2016 3 2017 8 100 (2017)) 2016 3 33

2015 2016 2017 2018 6 30 8.1%7.4%9.3% 9.6% 34

2015 35

[ ] [ ] 2017 12 21 (1) 3 1 36

(2) 10 37

14 38

2018 6 30 388 40

2015 2016 2017 2018 6 30 82.3%83.4%85.7% 89.8% 2015 2016 2017 2018 6 30 56.8%56.0%58.0% 57.0% 2015 2016 2017 2018 6 30 28.2%26.0%25.8% 24.3% 41

FDA PMDA 42

2013 12 25 2014 3 1 60 180 2015 2016 2017 12 31 2018 6 30 1,651.2 1,572.3 1,371.7 1,675.1 117.3 109.5 87.8 74.2 47

115 87 10 39 20 167 50 48

18 49

2016 2 54

15% 25% 2020 11 15% 25% 56

2018 6 30 4,203.4 2018 7 31 2018 6 30 40 58

[ ] [ ] 2002 2010 60

2008 GDP 2014 7.3% 2015 6.9%, 2016 6.7% 2017 6.9% 62

2015 11 11 230 (2015)) 2017 8 3 2008 1 1 2017 2 24 25% 2009 4 22 2014 1 29 2017 12 29 64

2011 7 27 2015 4 17 2018 6 15 2016 6 28 25% 10% 10% 10% 20% 65

2015 2 3 7 2009 12 10 698 698 7 7 7 (i) (ii) 7 7 2014 7 4 37 2013 5 10 2013 5 13 < > 2012 11 19 2012 12 17 66

2015 2 13 2015 6 1 13 37 37 37 13 (i) 30% (ii) 30% 37 37 37 67

37 1995 2005 7 2005 7 21 2005 7 21 2% 2005 9 23 1.5% 3.0% 2008 7 2010 6 19 2014 3 17 1% 2% 2015 11 30 68

[ ][ ] 2008 [ ] [ ] [ ] 2008 8 29 142 142 [ ] 69

2015 3 30 19 19 2015 6 1 19 142 19 19 142 19 19 19 19 19 (i) 10% 50% (ii) 70

10% 2006 7 14 2008 8 1 [ ] [ ] [ ] [ ] [ ][ ] [ ] 71

[ ] [ ] [ ] [ ] 72

[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 73

[ ] [ ] [ ] [ ] [ ] [ ] [ ] 74

[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 75

[ ] [ ] 76

[ ] 8.12 [] 8.12 (a) 3.05 (b) (c) (d) [ ] (e) (f) 77

[ ] 3.28 8.17 (i) (ii) 159 (iii) 50 (i) [ ] (ii) (iii) 3.29 15 (iv) 3.28 1 8.17 2010 6 3.28 1 3.28 8.17 3 78

3.28 3.29 [ ] 3 3.28 [ ] 8.08(1)(d) [ ] 8.08(1)(a) 8.08(1)(a) 25% 8.08(1)(d) 100 15% 25% [ ] [ ] [ ] [ ] [ ] [ ] (i) 15% (ii) [ ] [ ] [ ] 79

(iii) [ ] [ ] [ ] (i)(ii) (iii) 8.08(1) 25% (i) [ ] [ ] [ ] (ii) [ ] (iii) [ ] (iv) [ ] [ ] 80

[ ] [ ] 81

[ ] [ ] 82

[ ] [ ] 83

[ ] [ ] 84

[ ]... 99 17 10C... 6 3 2201... 18 4 25B... 8 1 15 B... 88 12 1602 85

[ ]... 123 10 B... 1 3 1 502 [ ] 1 46 3 50 [ ] [ ] 500 37 86

[ ] 10 99 53 [ ] 1 27 28 B 10 1 22 500 B 1014-1018 200232 [ ] 87

P.O. Box 309 Ugland House Grand Cayman KY1-1104 Cayman Islands 9 222069 183 54 www.hansoh.cn 99 79 501 183 54 18 4 25B 183 54 88

[ ] 181 27 45 89

[ ]Frost & Sullivan [ ] Frost Sullivan 1 [ ][ ] [ ][ ] [ ] [ ][ ][ ] [ ] [ ] 2013 31,669 2017 51,434 12.9% 1 Frost & Sullivan Frost & Sullivan 1961 Frost Sullivan Frost Sullivan 1,072,720 Frost Sullivan Frost & Sullivan [ ] [ ] Frost & Sullivan (i) (ii) (iii) (iv) (v) Frost Sullivan Frost Sullivan Frost Sullivan 90

2017 2022 9.5% 2022 81,004 2013 9,955 2017 14,304 9.5% 2022 20,978 2017 2022 8.0% 2013 4,875 2017 4,376 4,000 2017 20 20.5% 15 GMP 91

1.1 2025 2030 92

2017 8 2017 62.1% 2017 2013 2017 2017 2022... 12.7 13.8% 9.8%... 9.7 13.7% 13.5%... 14.7 4.7% 4.0%... 3.6 11.6% 13.8%... 8.1 11.7% 8.0%... 13.3 10.8% 8.9%... 9.5% 8.0% 93

2017 1,811 12.7% 2017 2022 9.8%2017 207 11.4% 2017 2022 15.1% 2.1%0.8% 45.4% 2017 27 13.0% 2017 2017 2013 370 2017 420 94

2017 1,394 9.7% 2017 2022 13.5% 2013 2022 5,000 4,000 3,000 2,000 1000 0 79.5 81.2 83.0 84.5 85.9 87.1 88.3 89.5 90.7 92.0 79.0 271.9 640.5 81.2 279.0 664.2 83.4 286.0 688.1 85.4 292.8 711.5 87.5 299.6 734.3 89.3 306.0 756.3 91.2 312.1 777.5 92.9 317.8 797.7 94.6 322.8 817.7 96.2 327.4 838.9 2,600.8 2,698.3 2,794.8 2,890.8 2,987.9 3,082.3 3,172.9 3,261.9 3,347.9 3,426.8 2017 73.43 19.7% 2013 133 9.2% 2017 190 15.0% 2022 381 (TKI) 95

2017 28 2017 2017 2017 14 2017 2017 2017 299.6 82.0 2017 96

2017 (NRDL) 2017 87.5 85.9 37.2% 25.4 2017 25 2017 2017 2017 97

AML 2017 8.224 2017 2017 2017 2,107 14.7% 2017 2022 4.0% 2022 2,559 2017 53 2013 2017 7.3% 2017 2022 13.6% 98

18 2017 10 2017 2017 I II II 98% 2017 4.53 2017 1.2 47.7%2022 2022 1.405 63.9% 2017 512 3.6% 2017 2022 13.8% 2017 DPP-4 GLP-1 SGLT-2 18 3.4% 147 42.6% 99

II 2017 23 2017 2017 2013 747 2017 1,165 11.7 2022 1,714 2017 2022 8.0 (i) (ii) (iii) 2017 48.2 (PPIs) 2017 34 4 2017 2017 100

2013 1,266 2017 1,908 10.8% 2017 2022 8.9% 2022 2,916 2017 79 215 2017 2022 20.8% 15.6% 2017 10.1% 75.6%2017 2017 2 2009 339 2017 7 36 36 2016 44% 70% 101

1 1 1 1 1 2018 3 21 2013 2018 3 27 2018 4 10 102

1985 7 1 2001 2 28 2013 12 28 2015 4 24 2005 5 1 2007 10 1 103

2018 3 21 2015 5 8 2025 2016 10 25 2030 104

2002 2 11 2002 4 1 2017 7 28 2018 2018 6 28 2018 7 28 2018 2018 6 30 2018 7 30 105

5 6 GMP 2004 8 5 2017 11 17 GMP 1988 3 17 1992 12 28 1999 6 18 2011 1 17 2003 1 1 2005 9 7 2011 8 2 GMP 6 GMP GMP 106

2015 8 9 2003 8 6 2017 9 1 I II III IV 107

5 6 108

2015 7 2015 7 22 2015 117 1622 2017 12 21 [2017]126 2018 5 17 2018 23 < > 2016 51 2016 3 4 5 12 34 5 2015 11 4 2016 5 26 [2016]41 109

[2017]68 2017 8 15 2015 8 9 [2015]44 [2016]8 2016 2 6 110

2012 2007 10 1 2018 2021 3 2016 5 25 < > 2016 106 2017 8 25 2017 100 3 111

2015 230 2015 11 11 2015 12 1 2015 12 1 2015 257 2017 100 2017 8 25 1999 6 18 2000 1 1 112

2005 11 1 2013 12 7 2016 2 6 2006 3 15 2006 6 1 1988 2 12 1988 9 1 2004 7 20 113

2 GSP 2004 2 4 2004 4 1 2017 11 7 5 6 GSP GSP GSP 2000 7 1 2013 6 1 2015 6 25 2016 7 12 2003 4 24 GSP 5 3 2007 1 31 2007 5 1 114

[2017]13 2017 1 24 2007 3 13 2007 5 1 2007 3 3 2007 5 1 1 2004 7 8 2017 11 17 [1999]290 1999 9 20 115

2009 8 18 2015 2 13 3 2012 2013 3 13 2013 5 1 1998 12 14 116

2007 7 10 2010 10 28 2011 7 1 1999 5 12 2009 11 27 2011 10 24 2013 3 25 2015 3 27 2016 1 21 2017 2 21 4 117

2015 4 24 2015 4 24 < > 2015 5 4 2015 6 1 2000 7 7 < > 2001 7 23 2009 1 17 [2009]7 2009 6 19 < > [2009]59 118

2010 7 7 2015 2 9 2016 4 21 2016 [2016]26 2016 12 26 [2016]4 2018 1 1 119

2013 12 25 2014 3 1 2007 12 10 120

1987 1 1 2009 8 27 1993 9 1 2000 7 8 2009 8 27 1994 1 1 2009 8 27 2013 10 25 2009 12 26 2010 7 1 1985 4 1 1992 9 4 2000 8 25 2008 12 27 2001 7 1 2002 12 28 2010 10 9 20 121

10 1983 3 1 1993 2 22 2001 10 27 2013 8 30 2002 9 15 2014 4 29 10 10 2016 3 23 2016 5 1 1994 1 1 2008 11 10 2016 2 6 2017 11 19 1994 1 1 2008 12 15 2011 10 28 17% 11% 6% 2018 4 4 122

[2018]32 2018 5 1 17% 11% 16% 10% 3% 2018 4 4 [2018]33 5 2018 4 27 [2018]47 2018 5 1 3% 2008 1 1 2017 2 24 2007 12 6 2008 1 1 25% 15% 2003 9 1 2016 7 2 1998 11 29 2017 7 16 2008 10 1 2015 4 9 2018 4 28 123

1989 12 26 2014 4 24 1984 11 1 1996 5 15 2008 2 28 2017 6 27 1996 4 1 2004 12 29 2013 6 29 2015 4 24 2016 11 7 1988 6 1 1995 8 29 2000 4 29 2015 8 29 1996 10 29 1997 3 1 1995 1 1 2009 8 27 2008 1 1 2012 12 28 2008 9 18 2010 10 28 2011 7 1 1999 1 22 1994 12 14 1995 1 1 1999 1 124

22 2004 1 1 2010 12 20 1999 4 3 2002 3 24 2006 9 8 2009 6 22 125

1996 4 1 1997 1 14 2008 8 5 < > 1996 6 20 1996 7 1 [2012]59 59 2012 12 17 2015 5 4 2014 7 4 [2014]37 2015 2 13 2015 4 1 [2015]13 1986 4 12 2000 10 31 2016 9 3 1990 12 12 2001 4 12 2014 2 19 10% 50% 126

2015 12 2 1995 (i) (ii) (iii) (iv) 2017 62.1% 2013 2017 1995... 2000... GMP 2002... 2002... GMP 127

2003... FDA 2005... 2005 20 2006... 2008... 2013... FDA GMP 2014... 1.1 2015... 2016... 128

PMDA 2017... 2017 22 2017 2017 2017 2017 AAA 2017 2018... 2018 129

1995 7 26 700,000 3 2001 12 16 East Pearl Holdings Limited 40.0%39.0%15.0%5.5% 0.5% East Pearl Holdings Limited 2002 7 18 2012 12 1 2014 6 23 East Pearl Holdings Limited 42.2% 40.0%11.0%5.8% 1.0% 130

2015 12 31 2016 4 2015 12 22 2015 12 30 2006 7 19 10,000,000 70.0% 30.0% 70.0% 30.0% 2015 6 30 70.0% 30.0% 2009 11 5 1,000,000 39.5% 2010 7 28 90.0% 2016 3 30 10.0% 131

2011 10 13 10,000,000 2013 6 27 100% 2014 6 23 2015 12 18 260,000,000 2015 12 17 1,000,000 70.0% 30.0% 2011 12 31 1,000,000 2016 3 16 2018 4 2 10,000,000 100,000,000 2018 8 16 51% 49% 132

2018 4 10 10,000,000 [ ] 1. 2015 12 2 2016 2 19 [ ] Stellar Infinity 81 81% Apex Medical 19 19% Stellar Infinity Sunrise Investment Sunrise Investment Sunrise 2. [ ] Fortune Peak 2015 12 2 Fortune Peak 2015 12 16 Fortune Peak 100 Fortune Peak Fortune Peak 2015 12 3 99 1 Fortune Peak Fortune Peak 133

Fortune Peak 100% 3. Sunrise 2016 1 28 Sunrise 2016 1 29 Sunrise Investment 1 Sunrise 2016 2 5 Stellar Infinity Sunrise Investment [ ] Sunrise Investment Stellar Infinity 81% 4. 2015 12 25 East Pearl Holdings Limited 42.2%40.0%11.0%5.8% 1.0% (1) 10% 134

(1) 100% 100% 81% 19% 100% 100% 100% 100% 90% 100% 100% 70% 30% (1) Apex Medical (2) 2016 3 30, 10% (3) 135

2006 9 8 2006 10 2009 6 22 2008 136

37 37 2015 6 [2015]13 13 37 2015 12 23 [ ] 2016 2 19 [ ] [ ] [ ] 179,906,705 1,412,195,672 300 2016 2 19 137

[ ] 3.0%[ ] [ ] [ ] [ ] [ ] (1) 2016 179,906,705 2016 1.1994 [ ] 2 19 2 19 1,412,195,672 9.4148 [ ] [ ] [ ]% [ ] (1) [ ] [ ] [ ] [ ] [ ] [ ] 2016 2 19 Apex MedicalStellar Infinity GL43-12 [ ] [ ] [ ] [ ] [ ] [ ] Hillhouse Capital Management, Ltd. Hillhouse CapitalHillhouse Capital 2005 Hillhouse Capital 138

Hillhouse Capital Hillhouse Capital [ ] TMT Hillhouse Capital 500 [ ][ ] [ ] (i) (ii)[ ] (iii) [ ] [ ] [ ] (i)[ ][ ] [ ] [ ][ ] [ ] 28 (ii) [ ] [ ][ ] [ ] 2010 10 13 [ ] [ ] 2012 10 [ ] HKEx- GL43-12 2013 7 2017 3 [ ] 2012 10 [ ] HKEx-GL44-12 [ ] [ ][ ] 50,000 [ ] [ ] [ ] [ ] [ ] [ ] 139

[ ] [ ] 140

(1) Apex Medical (2) Hillhouse Fund II, L.P. Hillhouse Fund III, L.P 50% Hillhouse Capital Hillhouse Fund II, L.P. Hillhouse Fund III, L.P. (3) 141

[ ] [ ] Sunrise () 100% Sunrise Investment () Apex Medical (1) () (2) () 100% Stellar Infinity () [ ]% [ ]% [ ]% [ ]% () 100% Fortune Peak () 100% () 100% () () 100% 100% 100% 70% 100% 51% () 100% () (3) () () () 49% () 30% (1) Apex Medical (2) [ ] [ ] [ ] (3) 142

(i) (ii) (iii) (iv) 2017 62.1% 2013 2017 2015 2016 2017 2018 6 30 82.3%83.4%85.7% 89.8% 1.1 2018 2020 15 20 2011 1.1 2002 1.1 1.1 1.1 II 2018 2020 CMC 1.1 30 2016 4,200 143

1,900 5,000 cgmp 16 2015 2016 2017 50.452 54.330 61.855 2016 2017 7.7% 13.9% 2018 6 30 37.742 2017 29.749 26.9% 2015 2016 2017 14.486 14.760 15.955 1.9% 8.1% 2018 6 30 10.423 2017 7.761 34.3% 2015 2016 2017 2018 6 30 92.6%92.7%92.6% 93.4% 28.7%27.2%25.8% 27.6% (i) (ii) (iii) (iv) 2017 62.1% 2013 2017 144

Frost & Sullivan 2017 9.1% 2014 2017 207 Frost & Sullivan 2017 2.5%2017 1,394 9.7% Frost & Sullivan 2017 53 2013 2017 7.3% 2017 11.7% Frost & Sullivan 2017 272 53.1% 2017 2011 1.1 20 2011 1.1 1.1 30 2002 1.1 1.1 2014 1.1 2002 1.1 145

II 2018 2020 II 1.1 2019 Bcr-Abl 1.1 2019 HS-10234 1.1 HS-10296 1.1 HS-10296 1.1 1.1 20 17.502 8.6% 2.0% 2015 33.3% 2017 43.7% 87 10 115 146

2018 2020 15 Frost & Sullivan 2017 8% 45% 2018 2020 2001 2018 Frost & Sullivan 2017 27 2013 2017 14.8% 38% 2010 2017 68.4% 2015 2014 5-2C(S-HTx) 2018 2020 1.1 HS-10296 147

2005 Frost & Sullivan 2017 28.4 2011 2017 42.6% 2017 2 2013 2018 5 Frost & Sullivan 2017 24.9 2015 2013 2017 2 1.1 Bcr-Abl TKI 2018 7 Frost & Sullivan 2017 39 HS-10296 1.1 EGFR-T790M TKIHS-10296 Frost & Sullivan 2017 EGFR 38 1.1 HS-10234 2020 2012 Frost & Sullivan 2017 2017 148

1.1 2014 2017 7 HS-10234 1.1 HS- 10234 III Frost & Sullivan 2017 543 Frost & Sullivan 2017 5,820 2017 360 2018 2020 1.1 2000 II Frost & Sullivan 2017 23.1 2017 22.7% 1.1 II GLP-1 2019 2017 48.2% (PPI) 149

2018 2020 2002 Frost & Sullivan 2017 34.3 2017 14.4% 2017 10.1% 75.6%2017 2018 2020 2018 6 30 4,200 1,900 5,000 150

FDA cgmp FDA 2016 PMDA FDA 2018 2018 6 30 16 20 30 2014 2013 2 20 2013 2014 151

15 2018 2020 1.1 1.1 HS-10296 2018 2020 11 8 152

2018 20 15 2018 2020 FDA PMDA cgmp 153

13 2015 2016 2017 2018 6 30 82.3%83.4%85.7% 89.8% 2017 27.2%39.5%15.9% 7.8% 2018 6 30 26.1%44.4%16.1% 5.8% 1.1 154

Frost & Sullivan 2017 9.1% 2014 2015 2016 2017 2018 6 30 14.639 14.733 16.817 9.833 2015 2017 7.2% 2018 6 30 2017 21.0% Frost & Sullivan 2017 11.4% 207 2013 2017 14.2% 2022 419 2017 8.0% 45.0% Frost & Sullivan FDA 2001 2004 2015 2018 5 2016 12 FDA 2018 FDA 2017 2018 6 30 25.8% 24.3% 2015 2016 0.7%2016 2017 13.1% 2018 6 30 2017 18.0% 155

Frost & Sullivan 2017 27 2013 2017 14.8% (extrapyramidal reactions) Frost & Sullivan 2011 2017 68.4% 2017 38.0% 2015 2014 2010 2013 2013 2013 2031 2032 2033 5 2C(S-HTx) 2014 2017 2 2017 Frost & Sullivan 2.1% 156

Frost & Sullivan 2017 2.5% 2015 2016 2017 2018 6 30 17.614 20.269 24.437 16.740 2015 2017 17.8% 2018 6 30 2017 48.6% Frost & Sullivan 2017 1,394 2013 2017 13.7% PMDA FDA 2005 2016 PMDA 2016 12 FDA FDA 2017 2 2017 2018 6 30 17.6% 20.5% 2015 2016 21.7%2016 2017 23.7% 2018 6 30 2017 53.5% Frost & Sullivan 2017 28 2013 2017 13.7% Frost & Sullivan 2011 2017 42.6% 157

2007 2012 2012 2013 2032 2025 FDA 2001 2013 FDA FDA 2004 2017 2018 6 30 14.5% 12.2% 2015 2016 3.7%2016 2017 20.3% 2018 6 30 2017 9.0% Frost & Sullivan 2017 73.43 14 2013 2017 4.5% Frost & Sullivan 2008 2017 67.4%2017 NCCN 158

2013 2006 2010 2014 2014 2015 2031 2032 2031 2023 2013 2017 2 2018 5 2017 2018 6 30 4.0% 3.9% 2015 2016 18.9%2016 2017 7.3% 2018 6 30 2017 34.5% Frost & Sullivan 2017 25 2013 2017 18.9% Frost & Sullivan 2015 2013 159

2013 2013 2034 2030 2035 2013 2017 2 2017 2018 6 30 1.4% 1.6% 2015 2016 89.2%2016 2017 32.0% 2018 6 30 2017 55.9% Frost & Sullivan 2017 8.2 2013 2017 30.5% 2017 2015 2031 160

2017 11 2017 7 Frost & Sullivan 2017 12 24 2013 2017 26.6% 2.5% 2017 162 2017 14.7% 2018 6 30 2036 Frost & Sullivan 2013 2017 2017 11.7 2015 2016 2017 2018 6 30 6.722 8.474 9.862 6.062 2015 2017 21.1% 2018 6 30 2017 23.2% Frost & Sullivan Frost & Sullivan 2017 53 2013 2017 7.3% 1.1 1.1 161

2014 2017 7 Frost & Sullivan 2017 58 2013 2017 5.7% 2011 2023 2035 2026 2035 18 2012 2017 2 2017 2018 6 30 3.8% 5.4% 2015 2016 85.9%2016 2017 26.0% 2018 6 30 2017 83.9% Frost & Sullivan 2017 10 2013 2017 28.7% 2015 2015 2013 162

2015 Frost & Sullivan 2017 15 2015 2017 13.2% 2017 2018 5 2018 2020 2018 5 2018 Frost & Sullivan 2017 2.081 2013 2017 22.1% 2033 Frost & Sullivan 2017 2015 2016 2017 2018 6 30 4.821 163

4.796 4.803 2.215 Frost & Sullivan 2017 512 272 II 2017 1.2 2017 47.7% 2022 63.9% II 2000 2004 2017 2018 6 30 7.6% 5.7% Frost & Sullivan 2017 23.1 2013 2017 7.3% Frost & Sullivan 2000 2017 22.7% 2012 2011 2012 2014 2027 2032 2028 2032 2015 2016 2017 2018 6 30 5.762 5.305 5.281 2.520 Frost & Sullivan 2013 2017 11.7%2017 1,165 164

2002 2004 2017 2018 6 30 7.0% 5.5% 2015 2016 6.4%2016 2017 0.7% 2018 6 30 2017 5.1% Frost & Sullivan 2017 34 2013 2017 18.7% Frost & Sullivan 2017 14.4% 2003 2003 2004 2030 1.1 6 1.1 2018 2020 30 15 1.1 165

(1) (1)... 2019 2020 2017... HS-10296 II 2019 1.1 2019 2017 2020 2017 2018 7 2019 1.1... HS-10234 III 2020 1.1... II 2017 10 2018 II 2017 7 2019 1.1 II 2016 11... 2017 4 2019 2017 2018 2017 2020 166

(1) (1)... (VTE) 2016 12 2018 2017 2020 2017 2020 2017 (1) 2018 2020 D2/5-HT2 2017 167

Frost & Sullivan 2017 32 4,640 2022 51 15 2018 2019 2031 D2/5-HT2A Frost & Sullivan 2017 28 2018 6 30 2022 50 7.92 2019 2020 2033 HS-10296 HS-10296 1.1 168

HS-10296 EGFR HS-10296 EGFR T790M HS-10296 EGFR Frost & Sullivan 2017 EGFR 35 38 HS-10296 II HS-10296 2019 HS-10296 Frost & Sullivan 2017 30 2017 Frost & Sullivan 2017 9.41 6,210 2022 17 18.40 2019 2020 1.1 Bcr-Abl TKI 169

Frost & Sullivan 2017 39 2022 140 2019 2025 2017 NCCN Frost & Sullivan 2017 82 2.174 2022 24 2018 2019 HS-10234 HS-10234 1.1 170

HS-10234 HS-10234 Frost & Sullivan 2017 173 543 2022 455 1,818 HS-10234 III 2019 2020 HS-10234 2033 HS-10234 2 (SGLT-2) II FDA SGLT-2 Frost & Sullivan 2017 11 Frost & Sullivan 2018 2022 24 8.448 2017 2018 171

1.1 GLP-1 II Frost & Sullivan 2018 6 30 GLP-1 Frost & Sullivan 2017 GLP-1 68 4.076 2022 GLP-1 204 16 III 2017 2019 2026 2017 -IV(DPP-IV) II Frost & Sullivan 2017 12 5,440 Frost & Sullivan 2022 19 172

2016 2019 2017 5-HT4 Frost & Sullivan 2017 39.7 4 2017 Frost & Sullivan 2022 5.143 2017 2018 Frost & Sullivan 2017 5.86 2022 7.48 2018 6 30 Frost & Sullivan 2020 2022 4.125 173

2019 2020 2017 Xa VTE Xa Frost & Sullivan Frost & Sullivan 2017 74 770 Frost & Sullivan 2022 18 2016 2018 2009 174

Xa Xa Xa Frost & Sullivan 2017 62 6.231 Frost & Sullivan 2022 27 2019 2020 2017 Frost & Sullivan 2017 16 1.715 Frost & Sullivan 2022 25 2019 2020 175

1.1 2017 2013 2018 Frost & Sullivan 2011 1.1 20 1.1 30 1 1.1 6 1.1 1.1 2014 1.1 2018 6 30 1,000 350 2015 2016 2017 2018 6 30 409.0 403.1 575.5 362.6 8.1%7.4%9.3% 9.6% 176

20 1.1 HS-20039 177

20 30 100 300 178

2016 179

2018 6 30 30 600 4,200 2018 6 30 10 180

181

30 2018 6 30 1,900 5,000 2015 2016 2017 2018 6 30 253266370 388 2015 2016 2017 2018 6 30 12 31 6 30 2015 2016 2017 2018... 258 253 266 370... 17 37 120 52... 22 23 16 34... (5) 13 104 18... 253 266 370 388 2017 A B C GSP 182

2015 2016 2017 2018 6 30 14.4%13.8%13.6% 11.6% 10 5% 2016 A B C GSP GSP GSP 183

60 180 (i) (ii) 0.2% GSP 184

2013 FDA 2012 FDA FDA 2018 FDA 2016 PMDA 185

(i) (ii) (iii) 2015 6 1 2015 5 1 2015 6 1 186

2018 6 30 GMP GMP cgmp 187

188

189

GMP cgmp 190

(1) 12 31 6 30 2015 2016 2017 2018 (%) (1) (%) (1) (%) (1) (4) (%) (2)... 2,620 1,600 61.2% 2,620 1,790 68.3% 2,620 1,990 76.3% 4,000 1,080 54.2% (3)... 26.0 16.0 61.6% 26.0 16.3 62.6% 26.0 18.0 69.3% 38.5 8.8 45.8% 1. 255 2. 3. 2018 1100 285 12.46 4. 191

50,000 25,435 2018 6 30 144,000 126,000 2018 6 30 270,000 23,898 2018 6 30 13 192

2018 2021... 7.50... 6.70... 16.00 (1) (2) (3)... 30.20 70 6,300 1 2018 2021 30.20 [ ] [ ] [ ] 193

35 2015 2016 2017 2018 6 30 1.35 1.172 1.005 0.54 56.3%36.3%31.6% 25.1% 2015 2016 2017 2018 6 30 0.986 0.645 0.334 0.179 26.3%16.2%7.3% 7.2% 2015 2016 2017 5% 35(b) 194

GMP 2003 FDA PMDA EDQM KFDA 2018 6 30 199 GMP (ICH) 195

GMP 196

115 5 87 10 39 20 47 20 167 50 2 197

198

2018 6 30 35 124 29,623 180,417 6,639 168,523 554,163 2018 6 30 5.01 2018 6 30 11.4% 15% 32L 6(2) 342(1)(b) 34(2) 199

200

201

2020 12 31 20160310... AA5180312... 2021 7 16 GSP (A-JS15-163)... 2020 11 15 GMP (JS20130191)... 2018 9 24 GMP (JS20130209)... 2018 10 31 GMP (JS20140286)... 2019 4 29 GMP (JS20140255)... 2019 6 2 GMP (JS20140313)... 2019 8 3 GMP (JS20150433)... 2020 6 10 GMP (JS20150489)... HS106 2020 12 7 202

GMP (JS20160598)... 2021 9 22 GMP (JS20160609)... 2021 10 20 GMP (JS20170675)... HS103 2022 5 25 GMP (JS20170693)... 2022 8 7 GMP (JS20170697)... HS102 HS201 2022 8 29 GMP (JS20170745)... 2022 12 18 GMP (JS20180777)... 2023 2 22 GMP (JS20180776)... 2023 2 22 GMP (JS20180814)... 2023 5 6 GSP GMP (JS20130191) GMP (JS20130209) 203

2018 6 30 7,959 2018 6 30 %... 1,132 14.22%... 1,012 12.71%... 199 2.5%... 4,125 51.83%... 1,491 18.73%... 7,959 100% 204

GMP GMP GMP 205

2015 2016 2017 2018 6 30 280 460 450 320 2017 206

2015 2016 2017 12 31 2017 2018 6 30 (i) (ii) (iii) (iv) 2017 62.1% 2013 2017 13 2015 2016 2017 2018 82.3%83.485.7% 89.8% 1.1 2018 2020 15 4 1.1 8 207

20 2011 1.1 2002 1.1 1.1 II 1.1 2018 2020 1.1 30 2016 4,200 1,900 5,000 cgmp 16 2015 2016 2017 50.452 54.330 61.855 2016 2017 7.7% 13.9% 2018 37.742 2017 29.749 26.9% 2015 2016 2017 14.486 14.760 15.955 2016 2017 1.9% 8.1% 2018 10.423 2017 7.761 34.3% 2015 2016 2017 2018 92.6%92.7%92.6% 93.4% 28.7%27.2%25.8% 27.6% 208

(i) (ii) (iii) (iv) 2015 2016 2017 86.8%88.8% 90.4% 2018 92.3% 2017 62.1% 2013 2017 2015 2017 12.1%12.5%9.8%8.9% 9.6% 2015 2017 3.7% 2015 2017 12.6% 2015 50.452 2016 54.330 2017 61.855 10.7% 209

Frost & Sullivan 2017 2022 9.8%13.5% 13.8% 8.0% 2017 2022 4.0% 2017 2022 13.6% 1.1 1.1 1.1 30 100 II 1.1 2018 2020 30 15 1.1 1.1 20 1.1 210

1.1 2016 3 211

27 13 2015 2016 2017 2018 13 82.3%83.4%85.7% 89.8% 212

2015 2016 2017 2018 7.4%7.3%7.4% 6.6% 2015 2016 2017 2018 44.4%43.8%43.7 41.3% 213

2015 12 2 2015 2016 2017 12 31 2018 6 30 2.3 3 214

2.4............... 20 3 10 3 5 4 215

3 216

12 31 6 30 2015 2016 2017 2017 2018 % % % % %... 1,463,942 29.0 1,473,305 27.1 1,681,680 27.2 812,642 27.3 983,320 26.1... 1,761,373 34.9 2,026,873 37.3 2,443,708 39.5 1,126,472 37.9 1,674,016 44.4... 672,215 13.3 847,390 15.6 986,175 15.9 491,971 16.5 606,236 16.1... 482,118 9.6 479,555 8.8 480,331 7.8 237,219 8.0 221,512 5.9... 576,174 11.4 530,462 9.8 528,067 8.5 265,901 8.9 252,047 6.7... 89,352 1.8 75,375 1.4 65,576 1.1 40,650 1.4 37,065 1.0... 5,045,174 100.0 5,432,960 100.0 6,185,537 100.0 2,974,855 100.0 3,774,196 100.0 13 2015 2016 2017 82.0%81.6% 81.8% 2017 2018 81.2% 79.2% 12 31 6 30 2015 2016 2017 2017 2018 % % % % %... 189,771 50.7 191,245 48.1 212,935 46.8 101,836 47.7 115,103 46.0... 80,208 21.4 86,724 21.8 103,829 22.8 49,430 23.2 58,402 23.3... 46,280 12.4 54,604 13.7 64,481 14.2 29,403 13.8 36,646 14.7... 58,314 15.5 64,706 16.4 73,926 16.2 32,804 15.3 40,041 16.0... 374,573 100.0 397,279 100.0 455,171 100.0 213,473 100.0 250,192 100.0 218

2015 2016 2017 2018 7.4%7.3%7.4% 6.6% 50.7%48.1%46.8% 46.0% 2015 2016 2017 2018 46.706 50.357 57.304 35.240 2015 2016 2017 2018 92.6%92.7%92.6% 93.4% 12 31 6 30 2015 2016 2017 2017 2018... 17,674 6,438 12,815 5,193 8,067... 55,889 64,725 54,307 9,186 12,227... 2,745 4,682 22,371 16,615 14,021... 1,965 2,645 1,597 829 894... 407 2 2 2 8... 2,811 7,319 2,138 344 727 81,491 85,811 93,230 32,169 35,944 219

12 31 6 30 2015 2016 2017 2017 2018... 1,444 776 531 246 606... 45,004 7,481 8,338 2,402 10,579... (5,298) (6,212) (7,431) (4,136) (9,127)... 832 3,210 (4,689) (3,616) 2,768... (369) (2,033) 2,708 1,776 1,091... 463 2,052 3,557 3,618 1,624 42,076 5,274 3,014 290 7,541 (i) (ii) (iii) (iv) 12 31 6 30 2015 2016 2017 2017 2018 % % % % %... 1,823,310 81.4 1,894,587 79.7 2,119,520 78.4 1,035,672 79.2 1,227,191 78.7... 81,668 3.6 125,797 5.3 202,364 7.5 93,311 7.1 104,452 6.7... 308,971 13.8 331,915 14.0 346,715 12.8 168,727 12.9 204,332 13.2... 26,281 1.2 25,741 1.0 35,601 1.3 10,697 0.8 22,582 1.4... 2,240,230 100.0 2,378,040 100.0 2,704,200 100.0 1,308,407 100.0 1,558,557 100.0 220

(i) (ii) (iii) (iv) (v) (vi) (vii) 12 31 6 30 2015 2016 2017 2017 2018 % % % % %... 234,523 51.6 280,085 52.1 328,720 53.5 159,768 56.2 199,102 54.1... 41,089 9.0 42,906 8.0 51,710 8.4 27,495 9.7 34,766 9.4... 18,422 4.1 22,276 4.1 24,875 4.1 10,683 3.8 16,634 4.5... 43,888 9.7 43,884 8.2 37,630 6.1 18,220 6.4 22,977 6.2... 41,888 9.2 56,340 10.5 62,685 10.2 25,220 8.9 33,076 9.0... 60,401 13.3 65,610 12.2 74,168 12.1 18,985 6.7 40,631 11.0... 14,508 3.1 26,871 4.9 34,287 5.6 23,685 8.3 21,106 5.8... 454,719 100.0 537,972 100.0 614,075 100.0 284,056 100.0 368,292 100.0 (i) (ii) (iii) (iv) v 221

12 31 6 30 2015 2016 2017 2017 2018 % % % % %... 123,882 30.3 145,653 36.1 189,791 33.0 96,198 37.6 121,271 33.4... 93,557 22.9 69,487 17.2 118,036 20.5 42,951 16.8 69,749 19.2... 38,703 9.5 36,560 9.1 41,575 7.2 22,886 8.9 23,155 6.4... 125,603 30.7 125,028 31.0 197,781 34.4 81,858 32.0 134,639 37.1... 27,235 6.6 26,337 6.6 28,361 4.9 12,233 4.7 13,795 3.9... 408,980 100.0 403,065 100.0 575,544 100.0 256,126 100.0 362,609 100.0 27 12 31 6 30 2015 2016 2017 2017 2018... 6 3,411... 6 3,411 12 31 6 30 2015 2016 2017 2017 2018... 219,770 256,219 244,283 131,369 189,370... 21,872 72,025 93,035 37,777 46,354... 241,642 328,244 337,318 169,146 235,724 222

16.5% 2008 1 1 25% 10 2018 6 30 2017 6 30 2017 29.749 7.993 26.9% 2018 37.742 2018 2017 8.128 1.707 21.0% 2017 9.833 2017 2 o 2017 7.763 1.400 18.0% 2018 9.163 2018 5 223

2017 11.265 5.475 48.6% 2018 16.740 2018 1 o 2017 5.043 2.698 53.5% 2018 7.741 (i) 2017 2 (ii) o 2017 4.223 0.378 9.0% 2018 4.601 2017 2018 2018 7 o 2017 1.093 3,770 34.5% 2018 1.470 2017 2 2017 12 2018 5 o 2017 3,970 2,220 55.9% 2018 6,190 2017 2 2017 4.920 1.142 23.2% 2018 6.062 2017 7 224

o 2017 1.110 9,310 83.9% 2018 2.041 2017 2 2017 2.372 1,570 6.6% 2018 2.215 o 2017 2.326 1,690 7.3% 2018 2.157 2000 2004 2018 2017 2017 2.659 1,390 5.2% 2018 2.520 o 2017 2.203 1,130 5.1% 2018 2.090 2002 2004 2017 2018 2017 2.135 3,670 17.2% 2018 2.502 1,330 720 900 225

2017 27.614 7.626 27.6% 2018 35.240 2017 92.8% 2018 93.4% 2017 3,220 370 11.5% 2018 3,590 2017 920 300 2018 1,220 2017 13.084 2.502 19.1% 2018 15.586 1.915 356 2017 2.841 8,420 29.6% 2018 3.683 3,930 2018 2,160 2017 2.561 1.065 41.6% 2018 3.626 5,270 2,670 2,510 226

2017 30 720 2018 750 2017 1.691 666 39.4% 2018 2.357 2017 17.9% 2018 18.4% 10 2017 7.761 2.662 34.3% 2018 10.423 2017 12 31 2016 12 31 2016 54.330 7.525 13.9% 2017 61.855 2016 14.733 2.084 14.1% 2017 16.817 10.5% o 2016 14.137 1.848 13.1% 2017 15.985 227

2016 20.269 4.168 20.6% 2017 24.437 11.5% o 2016 8.798 2.089 23.7% 2017 10.887 o 2016 7.472 1.518 20.3% 2017 8.990 o 2016 2.282 1,660 7.3% 2017 2.448 2017 2 o 2016 6,660 2,130 32.0% 2017 8,790 2017 2 2016 8.474 1.388 16.4% 2017 9.862 3.5% o 2016 1.853 4,820 26.0% 2017 2.335 2017 228

2017 4.803 2016 4.796 8.9% o 2017 4.701 2016 4.717 2016 2017 2017 5.281 2016 5.305 9.1% o 2017 4.354 2016 4.386 2016 3.973 5,790 14.6% 2017 4.552 (i) 2,170 (ii) 990 (iii) 1,710 2016 50.357 6.947 13.8% 2017 57.304 2017 92.6% 2016 92.7% 229

2016 8,580 740 8.6% 2017 9,320 1,770 2017 2,240 2016 640 640 100% 2017 1,280 2016 6,470 1,040 16.1% 2017 5,430 2016 23.780 3.262 13.7% 2017 27.042 (i) 2.249 (ii) 7,660 2016 5.380 7,610 14.1% 2017 6.141 2016 2.801 4,860 17.4% 2017 3.287 2016 4.031 1,724 42.8% 2017 5.755 4,850 7,280 4,410 230

2016 530 230 43.4% 2017 300 2017 2016 340 2017 2016 2016 3.282 910 2.8% 2017 3.373 2016 18.2% 2017 17.5% 10 2016 14.760 8.1% 2017 15.955 2016 12 31 2015 12 31 2015 50.452 3.878 7.7% 2016 54.330 2016 14.733 2015 14.639 13.8% o 2015 14.230 930 0.7% 2016 14.137 231

2015 17.614 2.655 15.1% 2016 20.269 13.4% o 2015 7.228 1.570 21.7% 2016 8.798 o 2015 7.202 2,700 3.7% 2016 7.472 o 2015 1.920 3,620 18.9% 2016 2.282 o 2015 3,520 3,140 89.2% 2016 6,660 2015 6.722 1.752 26.1% 2016 8.474 4.0% 2015 2016 o 2015 9,970 8,560 85.9% 2016 1.853 232

2015 4.821 250 0.5% 2016 4.796 9.0% o 2016 4.717 2015 4.748 2015 5.762 7.9% 2016 5.305 8.6% o 2015 4.684 2,980 6.4% 2016 4.386 2015 3.746 2,270 6.1% 2016 3.973 (i) 150 (ii) 650 (iii) 830 2015 46.706 3.651 7.8% 2016 50.357 2016 92.7% 2015 92.6% 2015 8,150 430 5.3% 2016 8,580 2015 233

1,770 1,130 63.6% 2016 640 2015 5,590 880 15.7% 2016 6,470 2015 22.402 1.378 6.2% 2016 23.780 7,130 4,410 2015 4.547 8,330 18.3% 2016 5.380 4,560 1,450 2015 4.090 590 1.4% 2016 4.031 2,410 2,180 2015 4,210 3,680 87.4% 2016 530 2015 6,000 340 234

2015 2.416 8,660 35.8% 2016 3.282 2015 14.3% 2016 18.2% 10 2015 14.486 2,740 1.9% 2016 14.760 [ ] [ ] [ ] 12 12 31 6 30 2015 2016 2017 2017 2018... 1,145,471 1,246,507 1,402,252 362,540 696,672... (594,707) 829,538 (614,271) 91,544 (670,417)... (606,962) (2,048,558) (730,475) (404,134) 235

2018 6.967 (i) 12.780 (ii) 6,970 (i) 6.156 (ii) 1.924 (iii) 6,060 2017 14.023 (i) 19.328 (ii) 1.314 (i) 4.663 (ii) 2.312 (iii) 7,840 2016 12.465 (i) 18.043 (ii) 1.154 (i) 6.920 (ii) 3.113 (iii) 9,500 2015 11.455 (i) 16.902 (ii) 1.077 (i) 2.965 (ii) 3.184 6,440 2018 6.704 (i) 34.839 (ii) 1.455 (iii) 3.670 (i) 31.524 (ii) 1.530 2017 6.143 (i) 47.447 (ii) 2.563 43.741 236

2016 8.295 57.914 (i) 47.731 (ii) 2.389 2015 5.947 122.054 118.215 2018 2017 7.305 (i) 4.041 (ii) 3.243 2016 20.486 (i) 23.685 (ii) 6.475 (i) 13.024 (ii) 4.000 2015 6.070 6.442 5,000 237

12 31 6 30 7 31 2015 2016 2017 2018 2018... 251,569 353,051 439,355 506,696 520,982... 2,468,407 1,723,535 2,192,518 2,809,253 2,636,810.. 149,250 42,962 62,382 290,450 212,101... 2,024,776 268,327 607,722 941,400 1,118,393... 100,000 867,125 849,446 860,158 886,145... 30,000... 161,192 208,699 266,444 292,816 433,294... 5,185,194 3,463,699 4,417,867 5,700,773 5,807,725... 58,210 44,908 98,794 183,645 211,795... 2,282,578 1,256,582 1,024,006 1,208,849 1,228,368... 22,587 56,057 41,512 44,592 28,140... 50,000... 105,404 50,283 63,362 60,314 17,585... 3,789,132 404,134 4,000,000... 6,307,911 1,811,964 1,227,674 1,497,400 5,485,888... (1,122,717) 1,651,735 3,190,193 4,203,373 321,837 2018 7 31 3.218 2018 6 30 42.034 (i) 40.000 (ii) 1.724 1.770 238

2018 6 30 42.034 2017 12 31 31.902 (i) 6.167 (ii) 3.337 (i) 1.848 (ii) 8,490 2017 12 31 31.902 2016 12 31 16.517 (i) 4.690 (ii) 3.394 (iii) 2.326 5,390 2016 12 31 16.517 2015 12 31 11.227 (i) 33.85 (ii) 10.260 (i) 17.564 (ii) 7.449 2.4 12 31 6 30 2015 2016 2017 2018... 38,941 63,541 82,321 104,380... 162,185 223,628 245,722 240,531... 50,443 65,882 111,312 161,785 251,569 353,051 439,355 506,696 239

2017 12 31 4.394 15.3% 2018 6 30 5.067 5,050 2016 12 31 3.531 24.4% 2017 12 31 4.394 4,540 2015 12 31 2.516 40.3% 2016 12 31 3.531 6,140 6 30 12 31 2015 2016 2017 2018 (1)... 42.7 47.1 58.5 68.1 (2)... 120.5 177.2 188.2 177.3 (3)... 46.8 53.4 71.0 99.6 (1) 365 (2) 365 (3) 365 240

60 180 90 180 12 31 6 30 2015 2016 2017 2018... 1,669,298 1,591,546 1,384,346 1,684,934... (18,127) (19,253) (12,598) (9,860) 1,651,171 1,572,293 1,371,748 1,675,074... 817,236 151,242 820,770 1,134,179 2,468,407 1,723,535 2,192,518 2,809,253 6 30 12 31 2015 2016 2017 2018 (1)... 117.3 109.5 87.8 74.2 (1) 365 241

2015 2016 2017 12 31 2018 6 30 24.684 17.235 21.925 28.093 2015 12 31 2016 12 31 6.66 2016 12 31 2017 12 31 2017 12 31 2018 6 30 2015 2016 2017 2018 117.3 109.5 87.8 74.2 12 31 6 30 2015 2016 2017 2018 90... 1,539,675 1,447,414 1,343,096 1,640,936 91 180... 104,643 118,202 23,030 30,486 180... 6,853 6,677 5,622 4,192... 1,651,171 1,572,293 1,371,748 1,675,074 12 31 6 30 2015 2016 2017 2018 90... 530,927 111,703 431,727 689,974 91 180... 284,509 39,539 389,043 441,600 180... 1,800 2,605... 817,236 151,242 820,770 1,134,179 242

12 31 6 30 2015 2016 2017 2018 90... 8,261 16,462 2,568 8,808 9 90 12 31 6 30 2015 2016 2017 2018... 58,210 44,908 92,454 78,797... 6,340 104,848 58,210 44,908 98,794 183,645 2015 2016 2017 12 31 2018 6 30 5,820 4,490 9,880 1.836 2016 2017 2018 243

12 31 6 30 2015 2016 2017 2018 (1)... 46.2 47.4 55.1 62.5 (1) 365 2017 2018 2016 35 12 31 6 30 2015 2016 2017 2018 90... 57,260 43,306 90,589 103,991 91 180... 160 132 7,627 78,296 181... 82 139 225 316... 708 1,331 353 1,042... 58,210 44,908 98,794 183,645 244

12 31 6 30 2015 2016 2017 2018... 41,482 48,150 32,784 56,043... 214,657 252,910 275,620 340,096... 458,830 350,966 369,166 546,183... 241,439 147,781 204,015 105,346... 1,197,175 326,504 8,104... 128,995 130,271 134,317 161,181... 2,282,578 1,256,582 1,024,006 1,208,849 35 12 31 6 30 2015 2016 2017 2018 (1)... 19,629 1,251 1,050 739 (2)... 2,005,147 267,076 606,672 940,661 2,024,776 268,327 607,722 941,400 (1) 245

(2) 1.35% 5.10% 12 31 6 30 2015 2016 2017 2018... 100,000 867,125 849,446 860,158 0.72 3.70 35 12 31 6 30 2015 2016 2017 2017 2018... 542 397 2 1... 3,492 4,401 262... 5,304 246

12 31 6 30 2015 2016 2017 2017 2018... 98,617 64,516 33,355 11,883 2,306... 560 6,292 9,008 5 206... 50,428 2015 2016 2017 2018 9,860 6,450 3,340 230 2016 5,040 2015 2017 2018 12 31 6 30 2015 2016 2017 2017 2018... 367,000 2018 7 31 247

6 30 12 31 2015 2016 2017 2018 5,788 18,802 81,214 6,410 170 44,385 65,029 73,096 63,111 9,178 9,436 10,643 6,388 7,369 8,974 4,607 2,309 78,040 74,318 96,343 140,182 3,542 5,662 6,741 158 28,901 148,472 211,122 272,644 218,558 2015 2016 2017 2018 1.485 2.111 2.726 2.186 2015 2016 2017 2018 248

12 31 6 30 2015 2016 2017 2018... 378 741 698 850... 403 59... 378 1,144 757 850 12 31 6 30 2015 2016 2017 2018... 106,508 189,837 176,344 106,361 2015 12 31 5,000 4.2% 2015 12 2016 1 2016 12 31 2017 12 31 2018 6 30 2018 7 31 2018 7 31 29 249

2018 7 31 12 31 12 31 6 30 6 30 2015 2016 2017 2018 (1)... 0.8 1.9 3.6 3.8 (2)... 22.5 26.2 29.8 31.8 (%) (3)... 28.7 27.2 25.8 27.6 (1) (2) 100% 2018 6 30 (3) 250

36 2015 2016 2017 2018 6.442 34.746 4.041 2015 2016 2017 2018 40.230 2018 7 31 2018 6 30 40.000 251

[ ] 10% 10% 50% 2018 6 30 40.864 2018 6 30 4.29 [ ] 2018 6 30 [ ] 2018 6 30 2018 6 30 [ ] 2018 6 30 252

[ ] 1. 2018 6 30 2018 6 30 5,571,827,000 13,733,000 2. [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 3. [ ] 2018 6 30 [ ] 4. [ ] 1.00 13.13 13.19 13.13 13.19 253

[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 2018 12 31 [ ] [ ] [ ] 2018 6 30 2018 6 30 254

[ ] 57 2015 1996 7 12 2 (1)(4) 42 32 2016 1998 7 3 11 (2) 2015 2011 12 2 (3)(4) 10 42 2016 3 11 2016 3 75 64 60 [ ] [ ] [ ] [ ] [ ] [ ] (1) 1998 9 (2) 2015 12 (3) 2011 10 (4) 2015 255

57 1998 9 FDA PMDA 2014 2016 2013 2 2013 12 2014 12 1982 7 2005 12 EMBA 256

42 2015 12 1998 7 2001 8 2009 3 2015 12 2016 4 2013 2014 2015 3 2017 10 2017 2018 5 1998 7 2005 6 2015 6 32 2011 10 2011 10 2007 6 257

42 2016 3 2005 6 Hillhouse Capital Management Ltd. 1998 7 2001 6 2012 3 75 [ ] 50 1968 1990 1988 1993 1993 1999 1980 1986 1992 Tetrahedron/Tetrahedron Letters 2008 2017 2001 258

2016 2016 12 2013 2013 12 1995 1995 12 1987 1987 7 1987 1987 7 1964 7 1968 7 64 [ ] 1977 1988 1994 2002 7 2012 6 1998 2001 [ ] 1998 1996 1999 259

2012 7 2015 12 12076030 2013 9 CYOU 1977 5 60 [ ] 1985 3 1992 3 1992 3 1999 3 1999 3 2007 2 2007 2 2016 5 603059 1982 7 1992 2 1998 12 (i) (ii) 13.51(2) (iii) 260

8.10 47 43 55 55 2012 3 1997 9 2013 1 2000 7 2009 3 1997 8 2016 10 2012 9 47 2012 3 1997 9 2003 2 1993 7 261

43 2013 1 2000 7 2002 2 2004 8 2009 3 2000 7 55 2009 3 1997 8 1997 10 1985 7 2008 12 55 2012 9 2016 10 2006 12 2012 7 Curis Inc. 2002 10 2006 12 1986 7 1989 12 1992 10 262

50 2018 8 2012 3 2010 6 1991 7 263

2015 2016 2017 12 31 2018 6 30 3.0 19.6 25.4 14.3 2015 2016 2017 12 31 2018 6 30 6.9 21.9 27.9 15.2 264

2018 12 31 28.6 [C. 2. ] [ ] [ ] [ ] [ ] D.[ ] [ ] [ ] 3A.19 (i) [ ] [ ] [ ] 13.46 265

(ii) [ ] 3A.23 A [ ][ ] 13.10 (iii) (iv) (v) 14 A.2.1 266

A.4.4 [ ] 267

[ ] Stellar Infinity [ ] [ ]% [ ] Stellar Infinity Sunrise Investment Sunrise Investment Sunrise Sunrise Sunrise Stellar Infinity Sunrise Investment [ ] Stellar Infinity Sunrise Investment [24.17]% Frost & Sullivan 4,000 Frost & Sullivan Frost 268

& Sullivan Frost & Sullivan 100 300 2015 2016 2017 2018 6 30 1.89%1.36%1.02% 0.66% 8.10 [ ] Sunrise Investment Stellar Infinity Sunrise Investment Stellar Infinity [ ] 269

(i) (ii) (iii) (iv) 270

[ ] (a) (b) (c) 388 30 (d) 30 600 4,200 271

(e) (f) 20 2018 6 30 1,000 (g) B. 2. (h) (i) 2015 2016 2017 12 31 2018 6 30 560,000 6,292,000 9,008,000 206,000 0.15%1.58%1.98% 0.08% 272

273

10% 10% 30% [ ][ ] 274

(a) (b) (c) 275

(d) (e) (f) (g) (h) (i) 276

(j) 277

[ ] [ ] [ ] [ ] 950,005... 9,500.05 49,995... 499.95 9,700... 97 300... 3 [ ] 20,000,000,000... 200,000 [ ] [ ]... 50,000 [ ] [ ] [ ] [ ]... [ ] [ ] [ ] [ ]... [ ] [ ] [ ] [ ] [ ] [ ] [ ] 278

[ ] (a) (b) (c) (i) [ ] 20% (ii) (1) (2) (3) A. 4. 279

[ ] [ ] 10% A. 7. (i) (ii) (iii) A. 4. 280

[ ] [ ] XV 2 3 [ ] 10% [ ] [ ] (1) Stellar Infinity (2)... 3,900,000,000 78% [ ] [ ] Sunrise Investment (2)... 3,900,000,000 78% [ ] [ ] Sunrise Trust (2)... 3,900,000,000 78% [ ] [ ] (2)... 3,900,000,000 78% [ ] [ ]... 3,900,000,000 78% [ ] [ ] Apex Medical... 950,000,000 19% [ ] [ ] (4)... 950,000,000 19% [ ] [ ] (1) [ ] (2) Stellar Infinity Sunrise Investment Sunrise Investment Sunrise Trust (3) Apex Medical [ ] [ ] [ ] XV 2 3 [ ] 10% 281

[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ][ ] [ ] [ ] (i) [ ][ ] [ ] (ii) [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 282

[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 2018 2020 15 [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 283

[ ] [ ] 284

[ ] [ ] 285

[ ] [ ] 286

[ ] [ ] 287

[ ] [ ] 288

[ ] [ ] 289

[ ] [ ] 290

[ ] [ ] 291

[ ] [ ] 292

[ ] [ ] 293

[ ] [ ] 294

[ ] [ ] 295

[ ] [ ] 296

[ ] [ ] 297

[ ] [ ] 298

[ ] [ ] 299

[ ] [ ] 300

[ ] [ ] 301

[ ] [ ] 302

[ ] [ ] 303

[ ] [ ] 304

[ ] [ ] 305

[ ] [ ] 306

[ ] [ ] 307

[ ] [ ] 308

[ ] [ ] 309

[ ] [ ] 310

[ ] [ ] 311

[ ] [ ] 312

[ ] [ ] 313

[ ] [ ] 314

[ ] [ ] 315

[ ] [ ] 316

[ ] [ ] 317

[ ] [ ] 318

[ ] [ ] 319

[ ] [ ] 320

[ ] [ ] 321

[ ] [ ] 322

[ ] [ ] 323

[ ] [ ] 324

[ ] I-5 I-70 2015 2016 2017 12 31 2018 6 30 2015 2016 2017 12 31 2018 6 30 I-5 I-70 [ ] [ ] 2.1 2.2 I-1

200 2.1 2.2 2.1 2.2 2015 2016 2017 12 31 2018 6 30 2017 6 30 2.1 2.2 2410 I-2

2.1 2.2 I-4 12 [ ] I-3

I. I-4

12 31 6 30 2015 2016 2017 2017 2018... 5 5,045,174 5,432,960 6,185,537 2,974,855 3,774,196... (374,573) (397,279) (455,171) (213,473) (250,192)... 4,670,601 5,035,681 5,730,366 2,761,382 3,524,004... 5 81,491 85,811 93,230 32,169 35,944... (2,240,230) (2,378,040) (2,704,200) (1,308,407) (1,558,557)... (454,719) (537,972) (614,075) (284,056) (368,292)... (408,980) (403,065) (575,544) (256,126) (362,609)... 5 42,076 5,274 3,014 290 7,541... 7 (6) (3,411)... 6 1,690,233 1,804,278 1,932,791 945,252 1,278,031... 10 (241,642) (328,244) (337,318) (169,146) (235,724)... 1,448,591 1,476,034 1,595,473 776,106 1,042,307... 1,448,591 1,476,034 1,595,473 776,106 1,042,307 1,448,591 1,476,034 1,595,473 776,106 1,042,307... 13 I-5

12 31 6 30 2015 2016 2017 2017 2018... 1,448,591 1,476,034 1,595,473 776,106 1,042,307... 75,387 (51,121) (19,050) 10,830... 75,387 (51,121) (19,050) 10,830... 75,387 (51,121) (19,050) 10,830... 1,448,591 1,551,421 1,544,352 757,056 1,053,137... 1,448,591 1,551,421 1,544,352 757,056 1,053,137 1,448,591 1,551,421 1,544,352 757,056 1,053,137 I-6

12 31 6 30 2015 2016 2017 2018... 14 995,337 1,048,085 1,171,490 1,304,266... 15 94,102 120,293 117,626 116,293... 16 4,693 6,061 9,178 13,733... 17 37,376... 113,777 182,813 157,887 108,200... 1,245,285 1,357,252 1,456,181 1,542,492... 18 251,569 353,051 439,355 506,696... 19 2,468,407 1,723,535 2,192,518 2,809,253... 20 149,250 42,962 62,382 290,450... 21 2,024,776 268,327 607,722 941,400... 22 100,000 867,125 849,446 860,158... 30,000... 23 161,192 208,699 266,444 292,816... 5,185,194 3,463,699 4,417,867 5,700,773... 24 58,210 44,908 98,794 183,645... 25 2,282,578 1,256,582 1,024,006 1,208,849... 26 22,587 56,057 41,512 44,592... 27 50,000... 105,404 50,283 63,362 60,314... 28 3,789,132 404,134... 6,307,911 1,811,964 1,227,674 1,497,400... (1,122,717) 1,651,735 3,190,193 4,203,373... 122,568 3,008,987 4,646,374 5,745,865... 17 34,649 127,684 174,038... 34,649 127,684 174,038... 122,568 2,974,338 4,518,690 5,571,827... 29 1 1 1... 30 122,568 2,974,337 4,518,689 5,571,826 122,568 2,974,338 4,518,690 5,571,827...... 122,568 2,974,338 4,518,690 5,571,827 I-7

* * * * * 2015 1 1... 147,720 445,048 3,842,151 4,434,919 4,434,919... 1,448,591 1,448,591 1,448,591... 18,550 (18,550)... 493,302 (493,302)... 406,690 (406,690)... (167,100) (167,100) (167,100)... (767,436) (767,436) (767,436)... 31 (168,176) (1,908) (633,322) (803,406) (803,406)... 11 (4,023,000) (4,023,000) (4,023,000) 2015 12 31 2016 1 1... (55,000) 55,000 122,568 122,568 122,568... 1,476,034 1,476,034 1,476,034... 75,387 75,387 75,387 75,387... 1 1,302,448 1,302,449 1,302,449... 150,000 (150,000)... (2,100) (2,100) (2,100) 2016 12 31... 1 1,302,448 (57,100) 75,387 205,000 1,448,602 2,974,338 2,974,338 I-8

* * * * * 2017 1 1... 1 1,302,448 (57,100) 75,387 205,000 1,448,602 2,974,338 2,974,338... 1,595,473 1,595,473 1,595,473... (51,121) (51,121) (51,121) 2017 12 31 2018 1 1... 1 1,302,448 (57,100) 24,266 205,000 3,044,075 4,518,690 4,518,690... 1,042,307 1,042,307 1,042,307... 10,830 10,830 10,830 2018 6 30... 1 1,302,448 (57,100) 35,096 205,000 4,086,382 5,571,827 5,571,827 2017 1 1... 1 1,302,448 (57,100) 75,387 205,000 1,462,374 2,988,110 2,988,110... 776,106 776,106 776,106... (19,050) (19,050) (19,050) 2017 6 30... 1 1,302,448 (57,100) 56,337 205,000 2,224,708 3,731,394 3,731,394 * 2015 2016 2017 12 31 2018 6 30 122,568,000 2,974,337,000 4,518,689,000 5,571,826,000 I-9

12 31 6 30 2015 2016 2017 2017 2018... 1,690,233 1,804,278 1,932,791 945,252 1,278,031... 369 2,033 (2,708) (1,776) (1,091)... 6 107,705 115,358 131,382 62,776 69,687... 6 2,316 2,265 2,667 1,374 1,334... 6 2,618 3,679 3,964 2,334 3,246... 5 (1,444) (776) (531) (246) (606)... (3,155) 10,624 (2,395) (222) (2,179)... 5 (59,523) (24,542) (18,758) (7,373) (16,468)... 5 (407) (2) (2) (2) (8)... 7 6 3,411 1,738,718 1,916,328 2,046,410 1,002,117 1,331,946... (69,674) (691,990) (466,275) (703,424) (615,644)... 69,436 459,547 (16,754) (41,796) (16,089)... (64,362) (95,021) (78,397) (57,017) (60,638)... 72,144 (13,302) 53,886 17,836 84,851... (318,438) (51,185) 109,131 309,867 161,584... 14,157 33,470 (14,545) (31,635) 3,080... 1,441,981 1,557,847 1,633,456 495,948 889,090... (296,510) (311,340) (231,204) (133,408) (192,418)... 1,145,471 1,246,507 1,402,252 362,540 696,672 I-10

12 31 6 30 2015 2016 2017 2017 2018... 421... 4,194 2,767 3,400 1,278 2,197... (1,154,500) (1,600,034) (905,742) (582,735) (558,909)... 1,529,000 888,276 872,064 582,735 558,909... (11,050,900) (3,173,100) (3,839,000) (1,393,000) (2,925,000)... 10,292,500 4,903,100 3,502,000 1,589,000 2,593,500... 20,407 2,144 10,149 6,657 10,088... 41,849 18,104 5,943 2,179 8,401... (97)... 237 15,825... 407 2 2 2 8... (367,000)... 153,000... (28,901)... (239,634) (238,926) (256,346) (108,907) (145,453)... (3,542) (5,662) (6,741) (5,665) (158)... (14,628) 15,522... (20,000) 30,000... (594,707) 829,538 (614,271) 91,544 (670,417) I-11

12 31 6 30 2015 2016 2017 2017 2018... 50,000 400,000... (450,000)... 31 (12,730) (647,489)... 1,302,449... (644,232) (2,368,507) (404,134) (404,134)... (167,200) (2,000)... (114,394) (324,341)... 7 (3,417)... (606,962) (2,048,558) (730,475) (404,134)... (56,198) 27,487 57,506 49,950 26,255... 217,390 161,192 208,699 208,699 266,444... 20,020 239 1,276 117... 161,192 208,699 266,444 259,925 292,816... 130,722 196,973 256,925 226,162 289,515... 30,470 11,726 9,519 33,763 3,301... 161,192 208,699 266,444 259,925 292,816 I-12

12 31 6 30 2015 2016 2017 2018... 463,207 436,310 441,813... 463,207 436,310 441,813 10,475 16,401 36,458 5,078 7,744 5,723 867,125 849,446 860,158 59,114 26,252 17,236... 941,792 899,843 919,575... 57 52... 57 52... 941,735 899,791 919,575... 1,404,942 1,336,101 1,361,388... 1,404,942 1,336,101 1,361,388... 1 1 1... 1,404,941 1,336,100 1,361,387... 1,404,942 1,336,101 1,361,388 I-13

II. 1. Maples Corporate Services Limited, PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman Islands (i)... (i)... (iv)... (ii)... Fortune Peak Company Ltd. Fortune Peak(iv)... 400,000,000 1995 7 100% 2006 7 100% 10,000,000 2009 11 100% 1,000,000 2011 10 100% 260,000,000 1 2015 12 100% I-14

(iii)... (i)... 100 2015 12 100% 2011 12 100% 2,000,000 (i) 2015 2016 2017 12 31 (ii) 2015 2016 2017 12 31 (iii) 2015 2016 2017 12 31 (iv) Fortune Peak 2.1 2015 12 2 2015 2016 2017 12 31 2018 6 30 I-15

2.2 2018 1 1 (a) (b) (c) I-16

(i) (ii) (iii) (i) (ii) (iii) 2.3 16 1 17 2 1 23 9 1 10 28 (2011) 3 19 1 28 1 2015 2017 3 11 11 23 1 1 2019 1 1 2 2021 1 1 3 2016 5 16 17 4 15 27 I-17

40 16 17 17 17 16 2019 1 1 16 16 33 2018 6 30 850,000 16 2.4 I-18

I-19

(a) (i) (ii) (iii) (b) (i) (ii) (iii) (iv) (v) (vi) (a) I-20

(vii) (a)(i) (viii)............... 20 3 10 3-5 4 I-21

... 3 I-22

(a) (b) (c) I-23

(a) (b) 90... 0% 90 1... 20% 1... 100% I-24

12 9 I-25

I-26

I-27

(a) I-28

(b) (c) (d) (e) I-29

3 2017 6 30 2015 2016 2017 12 31 2018 6 30 11,958,000 I-30

8,680,000 7,393,000 14,432,000 2015 2016 2017 12 31 2018 6 30 747,000 939,000 1,523,000 213,000 17 I-31

4 90 8 10% 5 I-32

12 31 6 30 2015 2016 2017 2017 2018... 5,045,174 5,432,960 6,185,537 2,974,855 3,774,196... 17,674 6,438 12,815 5,193 8,067... 55,889 64,725 54,307 9,186 12,227... 2,745 4,682 22,371 16,615 14,021... 1,965 2,645 1,597 829 894... 407 2 2 2 8... 2,811 7,319 2,138 344 727 81,491 85,811 93,230 32,169 35,944... 1,444 776 531 246 606... 45,004 7,481 8,338 2,402 10,579... (5,298) (6,212) (7,431) (4,136) (9,127)... 832 3,210 (4,689) (3,616) 2,768... (369) (2,033) 2,708 1,776 1,091... 463 2,052 3,557 3,618 1,624 42,076 5,274 3,014 290 7,541 I-33

6. 12 31 6 30 2015 2016 2017 2017 2018... 233,239 235,695 232,469 104,005 114,998... 107,705 115,358 131,382 62,776 69,687... 15 2,316 2,265 2,667 1,374 1,334... 16 2,618 3,679 3,964 2,334 3,246... 369 2,033 (2,708) (1,776) (1,091)... 1,857 3,687 2,879 1,355 996... 465 2,734 372 186 1,150. 5 (1,444) (776) (531) (246) (606)... 5 (407) (2) (2) (2) (8)... 5 (17,674) (6,438) (12,815) (5,193) (8,067)... 5 (45,004) (7,481) (8,338) (2,402) (10,579) 8... 608,642 688,292 778,376 388,960 471,073... 138,941 156,084 190,679 85,162 112,033 747,583 844,376 969,055 474,122 583,106 I-34

7 12 31 6 30 2015 2016 2017 2017 2018... 6 3,411 8 2017 6 30 12 31 6 30 2015 2016 2017 2017 2018...... 2,956 19,397 25,212 12,886 14,186... 65 207 219 111 114 3,021 19,604 25,431 12,997 14,300 I-35

2017 6 30 2015 12 31... (i) 2,956 65 3,021... (ii) 2,956 65 3,021 2016 12 31... (i) 14,169 69 14,238... (ii) 3,574 69 3,643... (iii) 1,654 69 1,723 19,397 207 19,604... (iv) 19,397 207 19,604 2017 12 31... (i) 17,413 73 17,486... (ii) 5,350 73 5,423... (iii) 2,449 73 2,522 25,212 219 25,431... (iv) 25,212 219 25,431 I-36

2018 6 30... (i) 10,065 38 10,103... (ii) 3,437 38 3,475... (iii) 684 38 722 14,186 114 14,300... (iv) 14,186 114 14,300 2017 6 30... 9,486 37 9,523... 2,754 37 2,791... 646 37 683 12,886 111 12,997... 12,886 111 12,997 (i) 2015 12 2 (ii) 2015 12 2 (iii) 2016 3 11 (iv) 2016 3 11 2017 6 30 I-37

9. 2017 6 30 13 33 3 8 4222 2 12 31 6 30 2015 2016 2017 2017 2018... 3,576 2,169 2,367 771 785... 260 138 146 74 76 3,836 2,307 2,513 845 861 12 31 6 30 2016 2016 2017 2017 2018 1,000,000... 3 2 2 1,000,000 1,500,000... 1 2 2 1,500,000 2,000,000... 4 2 2 2 2 10 16.5 I-38

2008 1 1 25% 2015 HNTE 2015 2017 15 2017 2018 2020 15 2017 2017 2019 15 12 31 6 30 2015 2016 2017 2017 2018... 219,770 256,219 244,283 131,369 189,370... 17 21,872 72,025 93,035 37,777 46,354... 241,642 328,244 337,318 169,146 235,724 I-39

12 31 6 30 2015 2016 2017 2017 2018... 1,690,233 1,804,278 1,932,791 945,252 1,278,031 25... 422,558 451,070 483,197 236,313 319,508... (154,707) (164,011) (168,445) (84,724) (120,917) (34,935) (39,910) (71,933) (28,015) (27,842)... 4,978 (361) 1,119 1,119 3,962... (1,997) (5,127) (632) (2) (8)... 1,552 7,270 8,051 2,442 5,726... 3,446 78,374 84,438 41,173 55,082... 747 939 1,523 840 213... 241,642 328,244 337,318 169,146 235,724 11 2015 12 31 4,023,000,000 12 13 2.1 2017 6 30 I-40

14 I-41 2015 12 31 2015 1 1... 694,457 5,514 410,881 56,083 55,135 76,134 1,298,204... (95,791) (1,897) (160,762) (31,703) (39,400) (329,553)... 598,666 3,617 250,119 24,380 15,735 76,134 968,651 2015 1 1 598,666 3,617 250,119 24,380 15,735 76,134 968,651... 5,788 170 44,385 9,178 7,369 78,040 144,930... (589) (2,133) (28) (2,750)... 57,509 1,713 1,499 (60,721)... (37,002) (1,479) (60,957) (10,149) (5,907) (115,494) 2015 12 31 624,372 2,308 233,127 24,880 17,197 93,453 995,337 2015 12 31... 756,993 5,683 448,154 64,982 52,338 93,453 1,421,603... (132,621) (3,375) (215,027) (40,102) (35,141) (426,266)... 624,372 2,308 233,127 24,880 17,197 93,453 995,337 2016 12 31 2015 12 31 2016 1 1... 756,993 5,683 448,154 64,982 52,338 93,453 1,421,603... (132,621) (3,375) (215,027) (40,102) (35,141) (426,266)... 624,372 2,308 233,127 24,880 17,197 93,453 995,337 2016 1 1 624,372 2,308 233,127 24,880 17,197 93,453 995,337... 18,802 65,029 9,436 8,974 74,318 176,559... (1,078) (346) (108) (459) (1,991)... 28,954 6,344 44,379 2,564 (82,241)... (38,171) (2,552) (61,493) (12,727) (6,877) (121,820) 2016 12 31 632,879 6,100 280,696 24,045 18,835 85,530 1,048,085 2016 12 31... 801,951 12,027 550,937 77,278 56,553 85,530 1,584,276... (169,072) (5,927) (270,241) (53,233) (37,718) (536,191)... 632,879 6,100 280,696 24,045 18,835 85,530 1,048,085

2017 12 31 2016 12 31 2017 1 1... 801,951 12,027 550,937 77,278 56,553 85,530 1,584,276... (169,072) (5,927) (270,241) (53,233) (37,718) (536,191)... 632,879 6,100 280,696 24,045 18,835 85,530 1,048,085 2017 1 1 632,879 6,100 280,696 24,045 18,835 85,530 1,048,085... 81,214 73,096 10,643 4,607 96,343 265,903... (1,715) (136) (86) (932) (2,869)... 7,026 1,144 42,349 1,055 (51,914) (340)... (43,432) (3,302) (72,148) (12,681) (7,726) (139,289) 2017 12 31 675,972 3,942 323,857 22,976 15,716 129,027 1,171,490 2017 12 31... 886,557 13,171 660,567 77,523 59,459 129,027 1,826,304... (210,585) (9,229) (336,710) (54,547) (43,743) (654,814)... 675,972 3,942 323,857 22,976 15,716 129,027 1,171,490 2018 6 30 2017 12 31 2018 1 1... 886,557 13,171 660,567 77,523 59,459 129,027 1,826,304... (210,585) (9,229) (336,710) (54,547) (43,743) (654,814)... 675,972 3,942 323,857 22,976 15,716 129,027 1,171,490 2018 1 1 675,972 3,942 323,857 22,976 15,716 129,027 1,171,490... 6,410 63,111 6,388 2,309 140,182 218,400... (161) (69) (812) (549) (1,591)... 58,236 91,675 4,820 (162,374) (7,643)... (26,460) (1,267) (38,655) (6,167) (3,841) (76,390) 2018 6 30... 713,997 2,675 439,919 28,017 13,372 106,286 1,304,266 2018 6 30 944,006 13,171 812,434 88,130 59,674 106,286 2,023,701 (230,009) (10,496) (372,515) (60,113) (46,302) (719,435) 713,997 2,675 439,919 28,017 13,372 106,286 1,304,266 I-42

2018 6 30 63,763,000 15 I-43 2015 1 1... 98,640...... (2,316) 2015 12 31... 96,324... (2,222)... 94,102 2016 1 1... 96,324... 28,901... (2,265) 2016 12 31... 122,960... (2,667)... 120,293 2017 1 1... 122,960...... (2,667) 2017 12 31... 120,293... (2,667)... 117,626 2018 1 1... 120,293...... (1,334) 2018 6 30... 118,959... (2,666)... 116,293

16 2015 12 31 2015 1 1... 6,214... (2,445)... 3,769 2015 1 1... 3,542... (2,618) 2015 12 31... 4,693 2015 12 31... 9,756... (5,063)... 4,693 2016 12 31 2016 1 1... 9,756... (5,063)... 4,693 2016 1 1... 5,662... (615)... (3,679) 2016 12 31... 6,061 2016 12 31... 14,191... (8,130)... 6,061 I-44

2017 12 31 2017 1 1... 14,191... (8,130)... 6,061 2016 1 1... 6,741... 340... (3,964) 2017 12 1... 9,178 2017 12 31... 21,273... (12,095)... 9,178 2018 6 30 2018 1 1... 21,273... (12,095)... 9,178 2016 1 1... 158... 7,643... (3,246) 2018 6 30... 13,733 2018 6 30... 29,074... (15,341)... 13,733 I-45

17. 2015 1 1... 11,010 2,742 36,164 6,934 3,614 239 60,703... (652) (803) (1,455)... 948 5,951 (29,855) 3,857 47 2,056 (16,996) 2015 12 31 2016 1 1... 11,958 8,041 6,309 9,988 3,661 2,295 42,252... (3,278) 11,444 (4,955) 2,712 172 1,845 7,940 2016 12 31 2017 1 1... 8,680 19,485 1,354 12,700 3,833 4,140 50,192... (1,287) (4,296) (24) 1,859 (1,262) (896) (5,906) 2017 12 31 2018 1 1... 7,393 15,189 1,330 14,559 2,571 3,244 44,286... 7,039 (3,253) (380) 5,843 (533) (987) 7,729 2018 6 30... 14,432 11,936 950 20,402 2,038 2,257 52,015 I-46

2015 1 1...... (1,430) (3,446) (4,876) 2015 12 31 2016 1 1... (1,430) (3,446) (4,876)... (1,591) (78,374) (79,965) 2016 12 31 2017 1 1... (3,021) (81,820) (84,841)... (2,691) (84,438) (87,129) 2017 12 31 2018 1 1... (5,712) (166,258) (171,970)... 999 (55,082) (54,083) 2018 6 30... (4,713) (221,340) (226,053) 2015 2016 2017 12 31 2018 6 30 11,958,000 8,680,000 7,393,000 14,432,000 2015 2016 2017 12 31 2018 6 30 747,000 939,000 1,523,000 213,000 10 2008 1 1 2007 12 31 5 2008 1 1 I-47

18 12 31 6 30 2015 2016 2017 2018... 38,941 63,541 82,321 104,380... 162,185 223,628 245,722 240,531... 50,443 65,882 111,312 161,785 251,569 353,051 439,355 506,696 19 12 31 6 30 2015 2016 2017 2018... 1,669,298 1,591,546 1,384,346 1,684,934... (18,127) (19,253) (12,598) (9,860) 1,651,171 1,572,293 1,371,748 1,675,074... 817,236 151,242 820,770 1,134,179 2,468,407 1,723,535 2,192,518 2,809,253 60 180 12 31 6 30 2015 2016 2017 2018 90... 1,539,675 1,447,414 1,343,096 1,640,396 91 180... 104,643 118,202 23,030 30,486 180... 6,853 6,677 5,622 4,192 1,651,171 1,572,293 1,371,748 1,675,074 I-48

12 31 6 30 2015 2016 2017 2018 90... 530,927 111,703 431,727 689,974 91 180... 284,509 39,539 389,043 441,600 180... 1,800 2,605 817,236 151,242 820,770 1,134,179 12 31 6 30 2015 2016 2017 2018 90... 8,261 16,462 2,568 8,808 9 2015 2016 2017 12 31 2018 6 30 91,439,000 892,333,000 242,535,000 37,137,000 I-49

20 12 31 6 30 2015 2016 2017 2018... 13,837 9,383 15,112 30,511... 2,222 2,667 2,667 2,666... 5,396 4,588 4,590 5,606... 19,139 10,142 19,157 23,499... 92,192 214,000... 784 5,078 7,744 5,723... 15,680 11,104 13,112 8,445 149,250 42,962 62,382 290,450 21 12 31 6 30 2015 2016 2017 2018... (a) 19,629 1,251 1,050 739... (b) 2,005,147 267,076 606,672 940,661 2,024,776 268,327 607,722 941,400 (a) (b) 1.35% 5.10% 22 12 31 6 30 2015 2016 2017 2018... 100,000 867,125 849,446 860,158 I-50

0.72 3.70 23 12 31 6 30 2015 2016 2017 2018... 130,722 196,973 256,925 289,515... 30,470 11,726 9,519 3,301... 161,192 208,699 266,444 292,816... 153,607 136,390 210,028 227,900... 7,585 72,119 54,933 64,659... 190 650 125... 833 132 161,192 208,699 266,444 292,816 24 12 31 6 30 2015 2016 2017 2018... 58,210 44,908 92,454 78,797... 6,340 104,848 58,210 44,908 98,794 183,645 I-51

12 31 6 30 2015 2016 2017 2018 90... 57,260 43,306 90,589 103,991 91 180... 160 132 7,627 78,296 181 1... 82 139 225 316 1... 708 1,331 353 1,042 58,210 44,908 98,794 183,645 90 25 12 31 6 30 2015 2016 2017 2018... 41,482 48,150 32,784 56,043... 214,657 252,910 275,620 340,096... 458,830 350,966 369,166 546,183... 241,439 147,781 204,015 105,346... 1,197,175 326,504 8,104... 128,995 130,271 134,317 161,181 2,282,578 1,256,582 1,024,006 1,208,849 26 12 31 6 30 2015 2016 2017 2018... 22,587 56,057 41,512 44,592 I-52

27 2015 12 31... 4.2 2016 50,000 12 31 6 30 2015 2016 2017 2018... 50,000 28 2015 2016 12 31 3,789,132,000 404,134,000 29 2015 12 100 0.01 2016 2 9,900 201,580,000 30 2017 6 30 I-53

(i) 10% 50% 25% (ii) 31 2015 12 31 2015 12 31 2015 12 31 2005 5 31 516,458,000 2015 12 31 I-54

... 1,455... 70,000... 681,723... 40,289... 12,730... (50,633)... (10,327)... 58,169 803,406 2015 12 31... (12,730)... (12,730)... 202,749... 31,994... 150,435... 46,229... 714 432,121... 215,368... 647,489 2016 12 31... (647,489)... (647,489) I-55

32 (a) 19 (b) 2015 1 1... 499,093 917 500,000... 50,000 50,000... (644,232) (644,232)... 50,000 (644,232) (594,232)... 647,489 647,489... 459,898 459,898... 110,597 110,597... 4,023,000 4,023,000... (88,719) 88,719... 6 6... 3,934,281 1,306,709 5,240,990 2015 12 31... 50,000 3,789,132 1,307,626 5,146,758 I-56

2016 1 1... 50,000 3,789,132 1,307,626 5,146,758... 400,000 400,000... (450,000) (450,000)... (3,417) (3,417)... (647,489) (647,489)... (135,557) (135,557)... (110,597) (110,597)... (2,278,871) (89,636) (2,368,507)... (50,000) (2,278,871) (986,696) (3,315,567)... 2,000 2,000... (1,106,127) (1,106,127)... 3,411 3,411... (1,106,127) 5,411 (1,100,716) 2016 12 31 2017 1 1... 404,134 326,341 730,475... (324,341) (324,341)... (2,000) (2,000)... (404,134) (404,134)... (404,134) (326,341) (730,475) 2017 12 31 2018 6 30... 2017 1 1... 404,134 326,341 730,475... (404,134) (404,134)... (404,134) (404,134) 2017 6 30... 326,341 326,341 I-57

33 12 31 6 30 2015 2016 2017 2018... 378 741 698 850... 403 59 378 1,144 757 850 34 12 31 6 30 2015 2016 2017 2018... 106,508 189,837 176,344 106,361 I-58

35 (a) East Pearl Holdings Limited East Pearl.............................. I-59

(b) 12 31 6 30 2015 2016 2017 2017 2018... 542 397 2 1... 3,492 4,401 262... 5,304... 98,617 64,516 33,355 11,883 2,306... 560 6,292 9,008 5 206... 50,428... 367,000 2018 7 31 I-60

(c) 12 31 6 30 2015 2016 2017 2018 (i)... 49 49... 92,192 214,000 92,192 214,000 (ii)... 46,227 22 16,797 46,227 22 16,797... 647,489 East Pearl... 374,862 311,644... 51,836... 2,000... 8,104 8,104... 114,321... 8,667 4,756 1,197,175 326,504 8,104... 1,612,152 East Pearl... 1,359,550 389,000... 233,423... 546,928... 37,079 15,134 3,789,132 404,134 I-61

(d) 12 31 6 30 2015 2016 2017 2017 2018... 11,267 28,870 35,734 16,348 17,706... 856 979 1,039 526 541... 12,123 29,849 36,773 16,874 18,247 8 36 2018 6 30... 2,809,253 2,809,253... 941,400 941,400... 76,450 76,450... 860,158 860,158... 292,816 292,816 941,400 4,244,573 4,980,077 I-62

2017 12 31... 2,192,518 2,192,518... 607,722 607,722... 62,382 62,382... 849,446 849,446... 266,444 266,444 607,722 3,370,790 3,978,512 2016 12 31... 1,723,535 1,723,535... 268,327 268,327... 42,962 42,962... 867,125 867,125... 208,699 208,699 268,327 2,842,321 3,110,648 2015 12 31... 2,468,407 2,468,407... 2,024,776 2,024,776... 149,250 149,250... 30,000 30,000... 100,000 100,000... 161,192 161,192 2,024,776 2,908,849 4,933,625 I-63

12 31 6 30 2015 2016 2017 2018... 58,210 44,908 98,794 183,645... 1,826,482 855,891 544,371 756,117... 3,789,132 404,134... 50,000 5,723,824 1,304,933 643,165 939,762 37 I-64

2018 6 30 1 2 3... 739 940,661 941,400 2017 12 31... 1,050 606,672 607,722 2016 12 31... 1,251 267,076 268,327 2015 12 31... 19,629 2,005,147 2,024,776 2015 2016 2017 12 31 2018 6 30 2015 2016 2017 12 31 2018 6 30 1 2 3 38 I-65

(a) 27 (b) 2018 6 30 %... 5 1,424 1,210... (5) (1,424) (1,210) 2017 12 31... 5 1,097 932... (5) (1,097) (932) 2016 12 31... 5 420 357... (5) (420) (357) 2015 12 31... 5 379 322... (5) (379) (322) I-66

2018 6 30 3 3 1 1 5 5... 756,117 756,117... 183,645 183,645 939,762 939,762 2017 12 31 3 3 1 1 5 5... 544,371 544,371... 98,794 98,794 643,165 643,165 2016 12 31 3 3 1 1 5 5... 855,891 855,891... 44,908 44,908... 404,134 404,134 1,304,933 1,304,933 I-68

2015 12 31 3 3 1 1 5 5... 1,826,482 1,826,482... 58,210 58,210... 50,000 50,000... 3,789,132 3,789,132 5,723,824 5,723,824 (e) 12 31 6 30 2015 2016 2017 2018... 6,307,911 1,846,613 1,355,358 1,671,438... 6,430,479 4,820,951 5,874,048 7,243,265... 98% 38% 23% 23% I-69

39 2015 2016 2017 12 31 2018 6 30 40 2018 7 31 4,000,000,000 41 2018 6 30 I-70

A. 4.29 [ ] 2018 6 30 [ ] [ ] 2018 6 30 2018 2018 6 30 6 30 [ ] [ ] 1 2 3 4 [ ] [ ]... 5,558,094 [ ] [ ] [ ] [ ] [ ] [ ]... 5,558,094 [ ] [ ] [ ] [ ] 1. 2018 6 30 2018 6 30 5,571,827,000 13,733,000 II-1

2. [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 3. [ ] 2018 6 30 [ ] [ ] 4. [ ] 1.00 II-2

[ ] II-3

[ ] II-4

[ ] II-5

1 [ ] 2 [ ] 2.1 [ ] [ ] 0.00001 2.2 (a) III-1

(b) (c) (d) (e) III-2

(f) (i) (ii) (iii) III-3

(iv) (A) (B) (v) (g) III-4

(h) (i) III-5

(ii) (iii) 12 (iv) (v) (vi) (vii) (i) (j) III-6

2.3 2.4 2.5 (a) III-7

(b) (c) 2.6 III-8

2.7 III-9

2.8 15 21 21 50% 2.9 III-10

21 2.10 21 14 III-11

(a) (b) 95% 2.11 (a) (b) (c) (d) (e) (f) III-12

10 6 30 60 2.12 2.13 2.14 III-13

(a) (b) III-14

2.15 12 48 III-15

48 12 2.16 14 15 14 III-16

15 2.17 10 6 30 60 2.18 III-17

2.4 2.19 2.20 III-18

2.21 (a) 12 (b) (d) (c) 12 (d) 12 1 2 2015 12 2 3 III-19

(a) (b) (c) 37 (d) (e) (f) III-20

4 34 34 3 5 Foss v. Harbottle (a) (b) (c) 6 III-21

7 8 (a) (b) (c) 9 III-22

10 11 12 13 (a) (b) (a) (b) III-23

14 75% 15 90% 16 III-24

17 (a) (b) 18 19 2018 6 (a) (b) (i) (ii) 2018 6(3) 20 III-25

21 III-26

A. 1. 2015 12 2 183 54 2018 9 13 16 183 54 2. 10,000 950,000 0.01 50,000 0.01 2015 12 2 Mapcal Limited 0.01 Mapcal Limited 0.01 2015 12 15 74 0.01 0.01 Apex Medical 20 0.01 2015 12 17 (i) 75 0.01 0.01 Stellar Infinity (ii) Apex Medical 0.01 Stellar Infinity (i)stellar Infinity 76 0.01 0.01 (ii)apex Medical 19 0.01 IV-1

2016 2 19 Apex Medical 1,881 0.01 Stellar Infinity 7,719 0.01 Stellar Infinity 0.01 0.01 10,000 950,005 0.01 49,995 0.01 300 0.01 (i) Stellar Infinity 7,800 0.01 (ii) Apex Medical 1,900 0.01 (iii) 300 0.01 [ ] 20,000,000,000 0.00001 10,000 950,005 0.01 49,995 0.01 10,000 200,000 (i)950,005 0.001 49,995 0.01 (ii)20,000,000,000 0.00001 [ ] 300 0.01 300 0.01 [ ]10,000 [ ] 10,000 0.01 950,005 0.01 49,995 0.01 200,000 20,000,000,000 0.00001 [ ] [ ] 50,000 [ ] 0.00001 [ ] 0.00001 [ ] [ ] [ ] [ ] 0.00001 [ ] IV-2

4. 3. 2018 8 16 10,000,000 100,000,000 4. [ ] (a) [ ] (b) 20,000,000,000 0.00001 10,000 950,005 0.01 49,995 0.01 10,000 200,000 (i)950,005 0.001 49,995 0.01 (ii)20,000,000,000 0.00001 (c) 300 0.01 300 0.01 (d) [ ] 10,000 (e) 950,005 0.01 49,995 0.01 200,000 20,000,000,000 0.00001 10,000 0.01 (f) (b) (e) [ ] [ ] 50,000 [ ] IV-3

[ ] [ ] [ ] (g) [ ] (i) [ ] [ ] (ii) [ ] (iii) [ ] [ ] [ ] (h) [ ] [ ] [ ] 20% IV-4

(i) [ ] [ ] 10% (j) (f) (g) (k) [ ] [ ] 5. [ ] 6. II 1 7. (a) [ ] (i) [ ] IV-5

[ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] 10% (ii) [ ] [ ] [ ] [ ] (iii) [ ] [ ] [ ] [ ] 10% 30 [ ] [ ] [ ] 5% IV-6

(iv) (v) (i) (ii) (vi) 30 (vii) IV-7

(b) [ ] (c) [ ] [ ] [ ] [ ] [ ] (1) (2) (3) (d) [ ] [ ] IV-8

26 25% B. 1. (a) [ ] (b) [ ] 2. IV-9

(a) 1 1032500 5 2017 6 21 2027 6 20 2 1134691 5 2017 12 14 2027 12 13 3 12515891 10 2014 10 7 2024 10 6 4 12515893 10 2014 10 7 2024 10 6 5 12515894 5 2014 10 7 2024 10 6 6 12516909 10 2014 10 7 2024 10 6 7 12516910 5 2014 10 7 2024 10 6 8 12516911 10 2014 10 7 2024 10 6 9 12882208 5 2014 12 28 2024 12 27 10 12882245 5 2014 10 28 2024 10 27 11 12882584 10 2015 3 14 2025 3 13 IV-10

12 12882595 10 2015 3 14 2025 3 13 13 1295275 5 2009 7 21 2019 7 20 14 13118866 10 2014 12 28 2024 12 27 15 13118867 5 2015 1 14 2025 1 13 16 13118868 10 2014 12 28 2024 12 27 17 13118869 5 2015 1 14 2025 1 13 18 13336594 5 2015 1 14 2025 1 13 19 13336639 5 2015 1 7 2025 1 6 20 13336771 5 2015 1 14 2025 1 13 21 13336786 5 2015 1 21 2025 1 20 22 13336807 5 2015 2 7 2025 2 6 IV-11

23 13336818 5 2015 2 7 2025 2 6 24 13336826 5 2015 2 7 2025 2 6 25 13336838 5 2015 2 7 2025 2 6 26 13336852 5 2015 3 28 2025 3 27 27 13336860 5 2015 1 21 2025 1 20 28 13336867 5 2015 1 21 2025 1 20 29 13336877 5 2015 1 21 2025 1 20 30 13336890 5 2015 1 21 2025 1 20 31 13336903 5 2015 1 21 2025 1 20 32 13336928 5 2015 1 21 2025 1 20 33 13338494 5 2015 1 28 2025 1 27 34 13338516 5 2015 1 14 2025 1 13 IV-12

35 13362080 10 2015 1 7 2025 1 6 36 13362223 5 2015 1 7 2025 1 6 37 13446105 10 2015 1 21 2025 1 20 38 13446130 10 2015 1 21 2025 1 20 39 13446141 10 2015 1 21 2025 1 20 40 13446164 10 2015 1 21 2025 1 20 41 13446177 10 2015 1 21 2025 1 20 42 13446378 10 2015 1 21 2025 1 20 43 13446404 10 2015 1 21 2025 1 20 44 13446421 10 2015 1 21 2025 1 20 45 13446436 10 2015 1 21 2025 1 20 46 13446446 10 2015 1 21 2025 1 20 IV-13

47 13446459 10 2015 1 21 2025 1 20 48 13446477 10 2015 1 21 2025 1 20 49 13446493 10 2015 1 21 2025 1 20 50 13446499 10 2015 3 7 2025 3 6 51 13446520 10 2015 1 21 2025 1 20 52 13446529 10 2015 1 21 2025 1 20 53 13446540 10 2015 1 21 2025 1 20 54 13446547 10 2015 1 21 2025 1 20 55 13446557 10 2015 1 21 2025 1 20 56 1362779 5 2010 2 14 2020 2 13 57 1362782 5 2010 2 14 2020 2 13 58 1362785 5 2010 2 14 2020 2 13 IV-14

59 1383431 5 2010 4 14 2020 4 13 60 1464527 5 2010 10 28 2020 10 27 61 1464528 5 2010 10 28 2020 10 27 62 14709290 10 2015 6 28 2025 6 27 63 14709337 10 2015 6 28 2025 6 27 64 14709386 10 2015 6 28 2025 6 27 65 14709415 10 2015 6 28 2025 6 27 66 14709458 10 2015 6 28 2025 6 27 67 14709497 10 2015 6 28 2025 6 27 68 14709532 10 2015 6 28 2025 6 27 69 14711025 5 2015 6 28 2025 6 27 70 14711078 5 2015 6 28 2025 6 27 IV-15

71 14711121 5 2015 6 28 2025 6 27 72 14711125 5 2015 6 28 2025 6 27 73 14711137 5 2015 6 28 2025 6 27 74 14848570 510 2015 7 21 2025 7 20 75 14848794 10 2015 10 14 2025 10 13 76 14848813 10 2015 10 14 2025 10 13 77 14848844 510 2015 7 21 2025 7 20 78 1504548 5 2011 1 14 2021 1 13 79 1556481 5 2011 4 21 2021 4 20 80 1664583 5 2011 11 14 2021 11 13 81 1672477 5 2011 11 28 2021 11 27 82 1672478 5 2011 11 28 2021 11 27 IV-16

83 3000738 5 2012 12 7 2022 12 6 84 3204039 5 2013 8 28 2023 8 27 85 3204040 5 2013 8 28 2023 8 27 86 3204041 5 2013 8 28 2023 8 27 87 3378067 5 2014 8 7 2024 8 6 88 3378068 5 2014 7 14 2024 7 13 89 3378388 5 2014 7 14 2024 7 13 90 3576918 5 2015 6 21 2025 6 20 91 3576919 5 2015 6 21 2025 6 20 92 3576920 5 2015 6 21 2025 6 20 93 3577126 5 2015 7 21 2025 7 20 IV-17

94 3608836 5 2018 4 14 2028 4 13 95 3608837 35 2015 6 7 2025 6 6 96 3608838 35 2015 6 7 2025 6 6 97 3608839 5 2015 12 7 2025 12 6 98 4149080 5 2007 4 14 2017 4 13 99 4149081 5 2007 4 14 2017 4 13 100 4361180 5 2018 1 7 2028 6 6 101 4580537 5 2018 7 21 2028 7 20 102 4580538 5 2018 7 21 2028 7 20 103 4580539 5 2018 7 21 2028 7 20 104 4664611 5 2008 10 7 2018 10 6 IV-18

105 4664612 5 2008 10 7 2018 10 6 106 4664613 5 2008 10 7 2018 10 6 107 4664614 5 2008 10 7 2018 10 6 108 4664615 5 2008 12 14 2018 12 13 109 4664616 5 2008 10 7 2018 10 6 110 4821918 5 2009 2 14 2019 2 13 111 4928153 5 2009 1 28 2019 1 27 112 4928454 5 2009 1 28 2019 1 27 113 4928460 5 2009 1 28 2019 1 27 114 4928461 5 2009 1 28 2019 1 27 115 4928462 5 2009 1 28 2019 1 27 116 4928463 5 2009 6 28 2019 6 27 IV-19

117 5483209 5 2009 9 28 2019 9 27 118 6483939 5 2010 3 28 2020 3 27 119 6483940 5 2010 3 28 2020 3 27 120 6483941 5 2010 3 28 2020 3 27 121 6550143 5 2010 4 7 2020 4 6 122 6550144 5 2010 4 7 2020 4 6 123 6550145 5 2010 4 7 2020 4 6 124 6723949 5 2010 5 21 2020 5 20 125 6797672 5 2010 6 7 2020 6 6 126 6797673 5 2010 6 7 2020 6 6 127 6797674 5 2010 6 7 2020 6 6 128 7897880 5 2011 1 28 2021 1 27 IV-20

129 8027076 5 2011 2 14 2021 2 13 130 13336442 5 2015 8 28 2025 8 27 131 13338603 5 2015 8 28 2025 8 27 132 14711067 5 2015 9 7 2025 9 6 133 15939272 5 2016 2 14 2026 2 13 134 15942707 5 2016 5 7 2026 5 6 135 15942727 10 2016 2 21 2026 2 20 136 15942728 5 2016 2 21 2026 2 20 137 15942832 10 2016 2 21 2026 2 20 138 15942855 10 2016 2 21 2026 2 20 139 17212055 5 2016 8 28 2026 8 27 140 17364886 5 2016 11 28 2026 11 27 IV-21

141 17383386 10 2016 10 21 2026 10 20 142 17665666 10 2016 9 28 2026 9 27 143 17665730 10 2016 9 28 2026 9 27 144 17665771 10 2016 9 28 2026 9 27 145 17665782 10 2016 10 7 2026 10 6 146 17665837 10 2016 10 7 2026 10 6 147 17669579 5 2016 10 7 2026 10 6 148 19552552 5 2017 5 28 2027 5 27 149 19558272 5 2017 5 28 2027 5 27 150 19558566 5 2017 5 21 2027 5 20 151 19558976 10 2017 5 28 2027 5 27 152 19726854 5 2017 6 14 2027 6 13 IV-22

153 19726910 5 2017 6 14 2027 6 13 154 20191658 5 2017 7 21 2027 7 20 155 20191822 5 2017 7 21 2027 7 20 156 19558804 10 2017 5 21 2027 5 20 157 19558859 10 2017 5 21 2027 5 20 158 19558915 10 2017 5 21 2027 5 20 159 19727050 10 2017 6 14 2027 6 13 160 19727064 10 2017 6 14 2027 6 13 161 20192097 10 2017 7 21 2027 7 20 162 20192248 10 2017 7 21 2027 7 20 IV-23

163 303686220 16 2016 2 16 2026 2 15 164 303774295 5 2016 5 13 2026 5 12 165 303774286 5 2016 5 13 2026 5 12 166 303686239 16 2016 2 16 2026 2 15 167 303774259 5 2016 5 13 2026 5 12 1 19552290 5 2016 4 7 2 19586182 5 2016 4 11 3 20191603 5 2016 6 3 4 20192295 10 2016 6 3 5 20192325 10 2016 6 3 IV-24

6 26025089 10 2017 8 23 7 26414720 5,10 2017 9 14 8 26788954 5,10 2017 10 10 9 26788967 5,10 2017 10 10 10 26789114 5,10 2017 10 10 11 26789337 5,10 2017 10 10 12 26790895 5,10 2017 10 10 13 26792377 5,10 2017 10 10 14 26792405 5,10 2017 10 10 15 26795407 10 2017 10 10 16 26795425 5,10 2017 10 10 17 26797473 10 2017 10 10 IV-25

18 26797482 5,10 2017 10 10 19 26797985 5,10 2017 10 10 20 26798727 10 2017 10 10 21 26799550 5,10 2017 10 10 22 26799557 5,10 2017 10 10 23 26800316 5,10 2017 10 10 24 26801840 5,10 2017 10 10 25 26804427 5,10 2017 10 10 26 26806649 5,10 2017 10 10 27 26808053 5,10 2017 10 10 28 28512194 35 2018 1 4 29 28648208 10 2018 1 11 IV-26

30 28652487 5 2018 1 11 31 28655846 5 2018 1 11 32 31118581 5 2018 5 23 33 31115150 10 2018 5 23 34 32395151 5 2018 7 21 35 32397067 10 2018 7 21 36 32703026 5 2018 8 6 37 26804427A 10 2017 10 10 38 26798727A 10 2017 10 10 39 26797473A 10 2017 10 10 40 26795407A 10 2017 10 10 41 304616587 16 2018 7 30 IV-27

42 304616604 5 2018 7 30 43 304616659 16 2018 7 30 44 304616668 5 2018 7 30 45 304616686 16 2018 7 30 46 304616695 5 2018 7 30 47 304617441 16 2018 7 31 48 304617432 5 2018 7 31 49 304617108 16 2018 7 31 50 304617261 5 2018 7 31 IV-28