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2 , BSc, ACGI, MBA, BSc, MBA, BEc, CA, BA, BA, LLL, JD, BSE, MA, MA, EdM, Solicitor, FCIS, FCS(PE), BSc, MBA, ACGI, MA, MBA, HonFCGI, BA, BMBCh, PhD, DM, DSc, FSB Panmure Gordon (UK) Limited Panmure Gordon (UK) Limited UBS Limited
3 *
4 2
5 3 100% 9,1804, ,110 4,6907,700 9,900 2,4802,950 AstraZeneca AB (Publ) ,4803,010 AZD b c-met AZD6094 c-met Fruquintinibb b Sulfatinib 32% b HMPL-523 Syk HMPL-523
6 4 - HMPL ,400 AZD6094 EGFR epitinib theliatinib b PI3Kδ HMPL-689FGFRHMPL % % 9,990 19% % 2,260 1,860-6% 1,3201, Earth s Best The Hain Celestial Group, Inc. HAINHain Celestial
7 5 (1) (2) Hain Celestial
8 6 +100% ,280 4,480 FDA AZD % % 1411,472
9 7 GMP 42 3, ,500 8 Hain Celestial 11,400 5,1104, ,030 5,320 (1) 2,630 (2) 2, Nutrition Science Partners LimitedNSP 7,700 9,900 2, ,380
10 8 100% 9,1804,600 5, , % 2, % , Hain Celestial %
11 9 710BT (b) HMPL-004 Anti-TNFα VEGF 1/2/ AZD6094 HMPL-523 VEGFR/FGFR EGFRm+ EGFR WT c-met Syk 2 EGFR 1 EGFR + AZD9291 EGFR + EGFR + c-met c-met c-met c-met c-met BT BT BT BT BT BT BT BT BT BT HMPL-689 HMPL-453 PI3Kδ FGFR
12 bpoc 10 1, % % HER2 trastuzumab FDA VEGF/VEGFR EGFR bevacizumab 71
13 ,730 gefitinib NSCLCEGFR 16,580rituximab TKIs VEGFR EGFR AbI c-met PI3K Syk FGFR TKI 24.8% 30.5% 19.7% 74 8% 23% 17 4% pemextredcapecitabine gemcitabine20% paclitaxel docetaxel 20% DNA oxaplatintemozolomide nedaplatin 11% letrozole bicalutamideanastrozole 6%
14 12 (1) AZD6094 c-methmpl-523 SykHMPL-453 FGFR (2) VEGFR EGFRHMPL-689 PI3Kδ (3)HMPL- 004 TNFα IL1-β NSP b PoC PoC PoC FDA ABTPAABTPA FDA (1) (2) (3) FDA ABTPA AZD6094 b PoC AZD6094HMPL-004 7,700 NSP 50/ AZD6094 HMPL ,4802,950 NSP NSP 7 4,480 3,010 PRCC AZD ,190 Hutchison MediPharma Holdings Limited 12.2% NSP 500
15 13 FTE NSP AZD6094 1, b FGFR HMPL-453 Syk HMPL-523 PI3Kδ HMPL-689 AZD6094 HMPL-504/volitinib / savolitinibazd6094 c-met c-met HGFR c-met c-met AZD6094 c-met c-met c-metc-met+ PRCC PRCC c-met 1~20% PRCC 40~75% AZD6094 c-met PRCC >30%) AZD6094 c-met c-met PRCCAZD c-metc-met O/E 40~92% c-metazd6094 c-met AZD c-met AZD6094 c-met c-met 1 PRCC27 PRCC 10~15% PRCC ASCO c-met AZD PRCC AZD PR>30% 1 AZD % 3SD 8 AZD6094PRCC ORR 38% PRCCORR 13.5% foretinib PRCC 74 AZD6094 PRCC ORR FDA AZD6094c-Met PRCC 5
16 NSCLCc-Met EGFR-TKI 140 NSCLC NSCLC 30% EGFR EGFRm+EGFREGFR- TKI EGFRm+ NSCLC 20 EGFR-TKI EGFR T790Mc-Met 45-50%15-20% erlotinib EGFRm+ EGFR-TKI EGFR-TKI AZD9291 FDA NSCLC T790MEGFR-TKI AZD9291 ORR64% %c-MetEGFR-TKI AZD9291AZD6094 EGFR-TKI 60-70% EGFRm+ c-met FDA ORR AZD c-met T790MEGFR-TKI NSCLC 10 4 EGFR c-met NSCLC 140 NSCLC 67% c-met 5 6 c-met %c-Met 40%c-Met 7 8 c-met AZD6094 c-met AZD6094 8AZD6094 c-met HMPL-504 volitinib 504 volitinib WHO INN volitinib INN savolitinib VEGF/VEGFR VEGF VEGFR
17 15 VEGF/ VEGFR TKI sorafenib sunitinib 1012 bevacizumab 71 VEGFR HMPL- 013 VEGFR VEGFR VEGFR 1, 2, 3 VEGFR b b 42 5 ORR 10.3% DCR 82.1% 9 OS 62% regoratenib 160 (n=136) ORR 4.4% DCR 51.5% 9 OS46%n=68ORR 0.0% DCR 7.4% 9OS24% b 11.9% 48.5% 71 = 2 1
18 16 b 420 VEGFR b PoC 18 IAS PoC (b) [1] Stivarga (b) 5 3/1 3 N = /1 N = 136 N = % 82.1% 66.7% 62% 4.4% 51.5% ~38% ~46% 0% 7.4% ~3% ~24% [1] = >30% = <20% =16 <20% = 9
19 17 2 NSCLC 80 NSCLC NSCLC NSCLC 90 NSCLC = 2 1 bevacizumab VEGFRNSCLC ramcirumab lenvatinib a 6 NSCLC 4 NSCLC NSCLC b 1 GMP VEGFR VEGFR FGFR VEGFR FGFR 3 50
20 18 NET octreotide/ everolimus/ sunitinib/ lanreotide/ NET (Ki67<10%) NET 15.6 / / / 5.5 NR / p <0.001 <0.001 < % / 2% 5% / 2% 9% / 0% NR 32% 67% / 37% 73% / 51% 63% / 60% NR 100% 12,000-15, everolimus 5% ORR10% DCR 70%octreotide 6% 35-45%lanreotide FDA Ki67 10% 0% 32% % 100% b / bb FDA b
21 19 FDA EGFR EGFR EGFR EGFR EGFR EGFR gefitinib erlotinib c-met c-met EGFR EGFR 53% 66-90% EGFREGFR 10 EGFR EGFR (1) EGFR (2) EGFR EGFR EGFR c-met EGFR EGFREGFR+ EGFREGFR O/E EGFR 10-30% EGFR EGFR EGFR EGFR EGFR 614 EGFR 27-54%EGFR EGFR EGFR EGFR 18 EGFR 62% 30-90%44-52%20-48%54-66%9-62% 68% EGFR HMPL-813 EGFR EGFR EGFR EGFR
22 b EGFR 10% 80% b b HMPL-309 EGFREGFR EGFR EGFR 60 EGFR 24 EGFR EGFR EGFR 90 T 120 RPTD b EGFREGFR HMPL-523 HMPL-004 HMPL- 523 Syk B HMPL-004 IBD HMPL-523 HMPL-523 Syk Syk T T B B B Syk Rigel Syk fostamatinib Syk R406 Syk Syk Syk
23 21 HMPL-523Syk IC 50( )* R788 R406 Rigel/ Syk, FLT-3, KDR, Src, Lyn, JAK rcia: 10/BID msle: 10/BID CLL: 80// 3 100BID 150QD 2ITP GS-9973 (Gilead) 55 * Syk 1NHL, CLL HMPL Syk rcia (QD) ED min = 0.7-1/ ED 50 = 1.4-2/ 1 Syk [1] Naive ph2.1 HCI HMPL- 523Syk Syk HMPL-523 HMPL MPK, QOD IP 10 MPK, BID, PO HMPL-523 (MPK, QD, PO) Enbrel R406 9 [1]MPK =QD = BID =QOD =PO = IP = Naïve = Fostamatinib Syk R406Enbrel TNF 46
24 22 [1] 1,800 HMPL [2] 1/3 HMPL-004 HMPL-004 NSP HMPL HMPL-004 HMPL-004 HMPL b HMPL-004 NSP NATRUL-3 HMPL HMPL-004 HMPL-004 NATRUL-3 NATRUL % b 2,400 HMPL NATRUL-3 5-
25 23 HMPL-004 2, b NATRUL % HMPL-004 2, % NATRUL NATRUL-3 HMPL-004 b NATRUL-3 NSP HMPL
26 24 HMPL-689 Gilead Sciences idelalisib PI3Kδ B PI3Kδ Infinityduvelisib PI3Kδ Bibrutinib ibrutinib BTK B HMPL-689 PI3K duvelisib PI3Kγ(gamma) HMPL-689 Idelalisib 150 HMPL-689 HMPL-689 P450 HMPL-689 idelalisib duvelisib IC 50 HMPL-689 Idelalisib Duvelisib PI3Kδ (n = 3) PI3Kγ (vs. PI3K δ) (142X) PI3Kα (vs. PI3K δ) >1 (>1,250X) PI3Kβ (vs. PI3Kδ) HMPL-453 FGFRHMPL (109X) (52X) (433X) (147X) (2X) (143X) (8X) HMPL- 523 HMPL-523 SykHMPL-079 Syk HMPL-689 idelalisib duvelisib Syk HMPL-523 Syk B
27 25 29% % % 9,9905,160 21% 2,2601,860 (i) %(ii) %(iii) 51% %(iv) % 20% 141 1,472 34%
28 % 5.6% 17.4% (1) (2) (3) (4) (5) - 12% %
29 % % 13.4% 16% 12% % 1,380 1,240 1,700 1,600 13,500 13,000 GMP 12 78, GMP
30 28 3,000 1,500 3, , % 3, ,500
31 29 19% % % 7% 6% 7,630 7, , % 5,560 H7N H3N % 4,140 3,050 13% 1,830 1,630 45% 1,470 1, ,3401,020
32 30 GMP 9 230,000 GMP 40 66, ,550-51% 49% 5, % 240 (1) 5.3 (2) 14 (3) 25% 60%
33 31 50% % 80% % [2] 50% % [1] 294 1,700 GSP [1] 50 GSP [1] 600 1, [1] GSP[2]
34 32-9% % , , % DHA omega-3 86,100 59,400 26, , , ,
35 33 6% 1,320 1, Hain Celestial Hain Celestial 14% 1,150 1,020 Earth s Best 125% % % % % % 1060 Earth s Best Earth s Best 250Hain Celestial Earth s Best
36 34 PoC b AZD6094 PRCC c-met bhmpl-523 b PoC HMPL-689 (PI3Kδ) HMPL-453 (FGFR) HMPL-004 Earth s Best
37 Hutchison MediPharma (Hong Kong) Limited Sen Medicine Company Limited
38 Hutchison Whampoa Japan K.K Hutchison Whampoa Europe Investments S.à r.l. (ITU) GSMA Limited Transport Initiatives Edinburgh Ltd. FPT Group Limited Railtrack Group plc Biological Reviews the Journal of Physiology Europace (BA) (BMBCh) (PhD) (DM) (DSc) (FSB) 56 Tempus Energy Limited GKN Evo edrive Systems Ltd Gasrec Limited NTR plc Current OpenGrid Limited Global Crossing Ltd. North West Water International Ltd. S.G. Warburg and Co. Ltd.
39
40 38 91(1) ,088, , ,600 41,000 30,542 20,000 2,475 (i)
41 (1) 768,182 (768,182) (3) 64,038 64, (1) 76,818 (76,818) (2) 26,808 26, (4) 40,857 40, (3) 102,628 (102,628) (3) 177,600 (77,600) 100, (3) 150, , (3) 896,386 (593,686) (5) 302, ,303,317 (1,025,228) (593,686) 684,403 (1) AIM 50% 25% (2) (3) 25% (4) (5) 593,686 (ii) Hutchison MediPharma Holdings Limited Hutchison MediPharma Holdings Limited
42 ,000 (40,000) (17,000) ,000 (30,000) (20,000) ,000 (300,000) (1) 25,000 (10,000) (10,000) 5, (2) 106,420 (924) (86,096) 19, (3) 1,187,372 1,187, ,420 1,187,372 (80,924) (433,096) (4) 1,211,772 (1) (2) 25% (3) 25% 25% (4) 433,096(a) 39,884(b) 393,212 3% Hutchison Healthcare Holdings Limited (1) HHHL 36,666, % Computershare Company Nominees Limited (2) CCNL 16,331, % (3) 2,640, % Slater Investments Limited (3) 2,263, % (1) HHHLHHHL (2) CCNL SC (3)
43 41 4th Floor, Hutchison House, 5 Hester Road, Battersea, London
44 42 AIM ( (
45 43 100% 4/4 4/4 4/4 4/4 4/4 4/4 4/4 4/4 4/4
46 44 AIMAIM AIM AIM 51
47 45 100% 3/3 3/3 3/3
48 46
49 47
50 48 AIM 100%
51 49 19,503 (1) (4) 19, ,888 (2) (4) 615,385 14,810 24,000 (5) 1,003, ,551 (2) 217,949 21,482 (5) 512,982 19,503 (3) 19,503 19,503 (1) 19,503 19,503 (3) (4) 19,503 51,488 51,488 51,488 51,488 51,488 51, , ,334 14,810 45,482 1,748,541 (1) (2) 19,503 (3) (4) (5) 100%
52 50 Investor Relations 4th Floor, Hutchison House, 5 Hester Road, Battersea, London 100% [email protected]
53
54 ,813 45,970 (72,049) (22,208) 19,764 23,762 (4,112) (3,452) (22,572) (21,295) 6 (182) 1, ,202 10, ,100 11,555 8 (1,516) (1,485) 6,584 10,070 9 (1,343) (1,050) 5,241 9, ,034 (1,978) 7,275 7,042 4,357 7,323 1,017 (1,408) 5,374 5, ,901 1,127 7,275 7,042 11(a) (b) (a) (b)
55 53 7,275 7,042 (2,819) 3,342 4,456 10,384 1,825 10,360 1,017 (1,503) 2,842 8,857 1,614 1,527 4,456 10,384
56 ,482 5, ,436 1, , , , , , ,405 1, ,446 14,789 2,563 1, ,591 1, ,125 46,863 94,130 67, , , ,076 52,051 41,813 36,819 94,889 88, ,994 15, , ,836
57 ,427 4, ,638 15, ,716 7, ,282 51, ,185 78, ,947 2, ,923 29,870 2,397 99,055 80,831 24,945 (11,400) 149, , , ,667
58 56 52,048 93,669 4,974 9, (89,989) 70,578 11,620 82,198 5,915 5,915 1,127 7, ,280 2, ,618 2,942 2, ,342 2,942 5,915 8,857 1,527 10,384 23(a) 3 6 (2) (168) (120) (243) 9,459 9,096 3,371 12,467 31(a) (577) (577) 52,051 93,675 5,016 12, (74,447) 88,870 15, ,836
59 57 52,051 93,675 5,016 12, (74,447) 88,870 15, ,836 5,374 5,374 1,901 7,275 (933) (933) (11) (944) (1,599) (1,599) (276) (1,875) (2,532) (2,532) (287) (2,819) (2,532) 5,374 2,842 1,614 4,456 23(a) 1,025 4,598 (2,943) 2,680 2, (182) (b) 7,526 7,526 23(b (ii)) (3) (4) (35) (42) (a) (1,179) (1,179) (234) (234) (234) 3,059 3,059 (2,250) (2,250) 53,076 98,273 2,661 9, (69,185) 94,889 24, ,883
60 58 29(a) (490) (4,065) (1,466) (1,485) (908) (1,181) 15,949 11,308 13,360 5,028 (3,729) (2,500) (5,000) (12,179) 29(b) 689 (20,219) (2,500) 3,059 (2,250) (1,179) (577) 8,205 14,261 (11,277) (568) 121 2,680 7 (641) 13,123 (7,500) 15,651 46,863 30,767 (417) ,946 46,863 38,946 46, , ,125 46,863
61 P.O. Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman Islands AIM 2 IFRS (a) 2(d) (b) 2(a)
62 60 2 (b) (c) (d)
63 61 2 (e) (f) 2(I)
64 62 2 (g) 2(f) (h) (i) (j) (k)
65 63 2 (l) (m) (n) (o) (p) (q)
66 64 2 (r) (s) (i) (ii) (t) (i)
67 65 2 (t) (ii) i)ii) iii) (u) (v) (w)
68 66 2 (x) (y) (i) (ii) (iii) (z)
69 (2) (2) (2) 19 (1) 27 (2) 9 (4) (2) (2) 11 (2) 14 (2) 15 (3) (1) (1) (2) (1) (2) (3) (4)
70 68 3 (a) (i) (ii) 28.5% 30.4%
71 69 3 (a) (iii) , ,000 (iv) ,000 69,000 (b)
72 70 3 (b) 27 53,205 51,508 94,889 88, % 58.0% (c) 4 2
73 71 4 (a)
74 72 4 (b) (c) 16 2(l) (d) (e) (f) 3 29(b)
75 73 5 (i) 66,985 16,470 (ii) 24,828 29,500 91,813 45,970 (40) 91,813 45,930 (i) 6, ,020.0 (ii) , , , (a) EBIT/(LBIT) 10
76 ,832 24, ,936 91,813 91,813 EBIT/(LBIT) 1,156 (2,614) (337) 999 (796) (6,865) (7,661) ,611 (8,409) 15,202 15,202 24,839 (10,990) (329) 1,002 14,522 (6,422) 8, ,410 1, , , , , , , ,767 52,606 1,173 7, ,596 21, ,938
77 75 5 EBIT 2,096 2,096 2,096 2,096 2,096 2,096
78 76 5 3,985 29, ,562 45,970 45,970 EBIT/(LBIT) 806 6,495 (80) (486) 6,735 (6,568) ,702 (8,765) 10,937 10,937 20,517 (2,239) (68) (484) 17,726 (6,171) 11, ,299 1, , , , ,271 50,272 1,768 8, ,623 27, ,736
79 (41) (40) (40) LBIT (1,141) (837) (1,978) (1,978) (1,141) (837) (1,978) (1,978) , ,000628,000 (LBIT)/EBIT (LBIT)/EBIT (796) 6,735 (6,865) (6,568) ,202 10,937 (1,516) (1,485) 6,584 10,070 11,458,000 6,823,000 79,000120,000
80 (480) 1, (281) (69) (182) 1, (i) 62,464 16,823 1, (ii) (ii) ,574 4, ,297 16,517 (i) 6, ,780.0 (ii) 88, ,00041,000
81 (a) 19 31(a) (a) ,516 1, , (136) 1,343 1,050 (a) 16.5% 16.5% (b)
82 80 9 (c) 6,584 10,070 4,464 5,115 (5,620) (4,453) 1, (1,062) (2,673) 1,161 1, ,343 1, % 50.8% 20.4% 10.4%
83 81 10 (i) 2,096 (31) (ii) (1,947) 2,096 (1,978) (62) 2,034 (1,978) 2,515 (1,239) 2,515 (1,239) (i) (40) 2, ,096 (31) (ii)
84 82 11 (a) 52,563,387 52,050,988 4,357 7,323 1,017 (1,408) 5,374 5, (0.0271) (b)
85 83 11 (b) 52,563,387 52,050, , ,438 52,901,145 52,878,426 4,357 7,323 1,017 (1,408) 5,374 5, ,432 1, ,748 1, ,864 12,953 1,370 1,096 3,195 2, ,297 16,517 9,442,0005,256,000
86 ,551 2, ,421 1,248 16,888 (60) (68) (2) (248) (28) (406) 29(b) ,215 2,380 3,729 (21) (388) (409) 1,671 1,097 (2,768) 2,491 4, , , , ,647 11,860 (19) (56) (2) (201) (278) 29(b) ,180 (19) (354) (373) 952 2, ,792 12,501 1,539 1, , ,482
87 ,472 2, ,059 14, ,211 1,230 2,500 (18) (148) (166) 2,551 2, ,421 1,248 16, , ,745 10, (17) (131) (148) 761 2, ,647 11,860 1, ,774 1,248 5,028
88 ,761 1,706 (41) 55 1,720 1, (6) ,436 1, (b) 1,546 1, ,000407,0001,546,000
89 % 5% 20% 11.0% 11.0% 11.6% 5% 5% 5% (b) GSP
90 ,883 61,883 46,131 49,522 31(b) 5, , ,405 40% (i) 50% Nutrition Science Partners Limited 43.79% (ii) NSP (i) 50% 20% (ii) NSP 50% 12.42% 12.24
91 89 18 (i) NSP 51,837 51,587 18,874 30,331 6,249 17,031 92,734 94,110 56,569 44,828 2, , ,697 75,443 75,159 8,548 17,061 73,552 59,446 67,731 35,646 30,000 30,000 (625) (7,476) (820) (10,000) (98,260) (91,760) (44,576) (38,484) (2,902) (4,604) (98,885) (91,760) (52,052) (39,304) (12,902) (4,604) (3,858) (3,180) (19,216) (5,025) 115, ,203 71,906 66,476 25,646 42,457
92 90 18 (ii) NSP 300, , , ,160 (3,645) (3,598) (2,651) (2,612) 1,317 1, (44) 24,553 20,386 31,505 26,620 (16,811) (17,543) (3,735) (3,408) (5,103) (4,196) 20,818 16,978 26,402 22,424 (16,811) (17,543) (2,352) 3,879 (1,895) ,466 20,857 24,507 23,272 (16,811) (17,543) 12,820 6,462 19,077 16,154 5,000 15,000 20,000 24,000
93 91 18 (iii) NSP ,203 95,808 66,476 59,358 42,457 60,000 (469) 20,818 16,978 26,402 22,424 (16,811) (17,543) (12,820) (6,462) (19,077) (16,154) (2,352) 3,879 (1,895) , ,203 71,906 66,476 25,646 42,457 50% 57,690 55,102 35,953 33,238 12,823 21,229 3,205 3,282 5,000 (1,901) (1,700) 55,789 53,402 39,158 36,520 17,823 21, ,000254,000 1,656 1,329 61,170 8,379
94 (2,947) (2,397) (2,690) (2,112) (2,112) (2,248) 29(b) (98) (363) (128) (2,690) (2,112) 7,877,000 9,036,000 23,531 14,855 8,647 10,098 10, ,097 5,672 1,148 1, ,507 41,198
95 , ,405 1, ,524 11,803 31(b) 1,922 2,986 34,446 14,789 3, , ,670 1, (62) 74 1,793 1,670 1,793,0001,670,000
96 ,130,0003,703,000 1, ,106 1,608 2,130 3, ,019 20,946 (a) 6,927 25,917 (a) 12,179 51,125 46,863 8,104 12,203 (b) 40,213 32, ,543 1, ,125 46,863 (a) % 2.1% (b)
97 95 23 (a) 1 75,000,000 75,000 52,048,448 52,048 3, ,051,448 52,051 52,051,448 52,051 1,025,228 1,025 53,076,676 53, , ,182 76, ,628 77, ,
98 96 23 (b) (i) ,038 (A) ,808 (B) ,857 (C) ,000 (A) ,000 (A) ,700 (A) 684,403
99 97 23 (b) (i) ,303, ,459, , (1,025,228) 1.54 (3,000) 4.97 (50,000) (D) 6.10 (593,686) , ,303,317 (A) 25% (B) (C) (D) 593,686 23(b)(ii)(D) (E) 684, ,000224,000 (A) 808,000206,000
100 98 23 (b) (i) (i (v) 38.8% 40.0% 35.0% 48.4% 46.6% 36.0% 4.766% 5.098% 4.700% 3.360% 3.130% 3.160% % 0% 0% 0% 0% 0% (i) (ii) (iii) (iv) (v)
101 99 23 (b) (ii) Hutchison MediPharma Holdings Limited ,000 (A) ,400 (B) ,187,372 (C) 1,211,772
102 (b) (ii) , ,144,505 (D) ,187,372 (E) 1.50 (80,924) 2.15 (393,212) 2.03 (120,896) (F) 1.70 (39,884) 1.79 (2,485,189) ,211, ,420 (A) (B) 25% (C) 25% 25% (D) 1,187,372 23(b)(i)(D) (E) 4.55 (F) (G) 1,211, ,000 60, ,000
103 (b) (ii) % 55% 48.4% 2.007% 2.439% 1.660% % 0% 0%
104 ,994,00015,966,000 11,068,000 10,587,000 Hutchison BYS (Guangzhou) Holding Limited5,598,000 3,626, ,0001,753,000 7,552,000 20% (i) 12.42% (ii) 50% (iii) 49 (i) 5 4 (ii) (iii) 5 3 (i) ,965 21,215 5,884 8,230 33,251 55,722 53,335 27,026 28, (897) (1,060) (11,456) (19,928) (4,253) (4,734) (18,346) (3,434) (3,265) (5,100) (9,600) (186) 51,598 49,182 43,535 29,391 (3,460) (6,059) 15,538
105 (ii) 24,828 29,500 11,531 10,157 50,202 10,272 8,286 (11,219) (2,238) 2,721 (1,215) 106 (489) (446) (21) (193) (51) 9,783 7,840 (11,219) (2,259) 2,528 (1,215) 55 (1,470) 1,352 (408) ,313 9,192 (11,627) (1,964) 2,599 (1,167) (a) 1,
106 (iii) (17,521) 2,903 3,516 (136) 6,858 (3,734) (2,457) 10,274 20,000 3,982 (4,500) (4,769) (1,255) 4,428 (984) (136) 12, ,969 8,227 4,525 4,609 (265) 314 (38) ,449 12,969 3,503 4,525 12,363 31
107 ,237 1,811 31(b) 2,190 2,352 20,427 4,163 1, , ,988 5,327 3,178 3,047 5,908 3,895 13,074 12, , ,120 13,638 15,389
108 (i) 26,923 (i) (ii) 26,282 51,508 53,205 51, % 1.80% (i) 26,923,000 (ii) (a) 26,282 51,508 26,923 53,205 51,508 (b) 53,205 48,718 2,790 53,205 51, , ,574, %87.76%
109 (a) 7,275 7,042 1,405 1, , (559) (451) (15,202) (10,937) 1,516 1, (2,903) (55) (451) (5,323) 1,412 (394) 89 (89) 324 (614) (19) (88) 2, (2,534) 160 1,320 1, (86) (490) (4,065) (3,005) (2,826) 10 2,515 (1,239) (490) (4,065)
110 (b) 9,597,000 51% 9,597 10, (i) ,208 21,105 (14,827) (105) (198) (4,769) (ii) (7,526) 8, (iii) 1,546 9,597 10,286 (9,597) 689
111 (b) (i) GSP (ii) (iii) 1,546,000 (iv) 50,202,000 55,000 71,344, ,000 (v) 23, (a) (b) ,425 1, ,734 2,888
112 (a) 7,823 7,803 4,191 3,612 6,727 6,304 2,480 9,207 6, ,
113 (b) 21 (i) 1,922 2, (i) 2,190 2,352 (i) (i) 89 (i) 1,484 1,808 1,591 1,985 (ii) 5,000 (iii) 8,694 7,374 (i) 22 8,716 7,374 (iv) (v) 2,550 4,800 3,129 5,379 (i) (ii) (iii) (iv) (v)
114 Hutchison Healthcare Holdings Limited ,500, % 87.76% 100% 100% 207,460,000 1,000,000 50% 50% 3,000,000 50% 50% 1 100% 100% 51% 63,570,000
115 % 40% 200,000,000 50% 50% 229,000,000 Nutrition Science 20, % 43.88% Partners Limited
116 114 AIM HCM P.O. Box 309, Ugland House Grand Cayman, KY Cayman Islands Computershare Investor Services PLC The Pavilions Bridgwater Road Bristol BS99 6ZY United Kingdom +44 (0) (0) Computershare Investor Services (Jersey) Limited Queensway House Hilgrove Street, St. Helier Jersey, Channel Islands JE1 1ES +44 (0) (0) (a) (b)
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, BSc, ACGI, MBA, BSc, MBA, BEc, CA, BA, BA, LLL, JD, BSE, MA, MA, EdM, Solicitor, FCIS, FCS (PE), BSc, MBA, ACGI, MA, MBA, HonFCGI, BA, BMBCh, PhD, DM, DSc, FSB Panmure Gordon (UK) Limited Panmure Gordon
2018 Hope Education Group Co., Ltd
2018 Hope Education Group Co., Ltd. 2018 7 14 2018 8 3 1 2018 Hope Education Group Co., Ltd. 2018 7 14 2018 8 3 2 2018 Hope Education Group Co., Ltd. 2018 7 14 2018 8 3 1 Hope Education Group Co., Ltd.
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0151 2011 6 30 6 30 2011 2010 % 1,279,454 1,002,392 +27.6 421,920 381,658 +10.5 203,595 195,451 +4.2 1 239,122 224,216 +6.6 167,018 161,259 +3.6 % % 33.0 38.1-5.1 15.9 19.5-3.6 13.1 16.1-3.0 15.3 16.6-1.3
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2014 2 3 7 11 14 23 30 32 34 35 37 38 39 114 1 2005 Cricket Square, Hutchins Drive P.O. Box 2681 GT, Grand Cayman KY1-1111, Cayman Islands 18 49 4902-03 Royal Bank of Canada Trust Company (Cayman) Limited
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Kingsoft Corporation Limited 03888 KINGSOFT CLOUD 2013 2 278 78 48 183 17M 2013 2 7 ......................................................................... 1 3 1..................................................................
20,232,000 4,310,000 0.33 20,232,000 19,134,000 5.7% 4,310,000 5,184,000 2014/15 2 100% 5.7% 20,232,000 19,134,000 3 2014/15 20,232,000 19,134,000 5.7% 14,351,000 13,032,000 16,783,000 16,326,000 4,310,000
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Boyaa Interactive International Limited 0434 238 1 2 12 15 183 17M 48 ... 1... 3... 4... 5... 7... 8... 8... 8... 8... 9... 12 i 238 1 2 12 15 1 5 571 0.00005 6 2 Boyaa Interactive International Limited
40% 6 1920 21 22 40 138 15 N-1 N-3 (http://www.hkexnews.hk) (http://www.tfkf.com.hk) 183 22 .................................................................. 1............................................................
2016 2 3 6 14 15 21 31 33 35 36 37 39 103 104 1 2016 * * * * 168 200 14 1407 http://arttextile.etnet.com.hk Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY1 1111 Cayman Islands Royal Bank of
,787,321 6,292,569 (3,178,103) (3,422,560) 2,609,218 2,870, ,824 85,775 (1,766,182) (2,108,497) (477,730) (536,273) (79,000) (98,0
Bosideng International Holdings Limited 3998 3 31 8.0% 5,787.3 0.5 45.1% 112.5% 280.9 708.7 2.6 3 313 31 1 3 31 3 31 3 5,787,321 6,292,569 (3,178,103) (3,422,560) 2,609,218 2,870,009 4 55,824 85,775 (1,766,182)
2 981, ,770 7 (240,945) (77,087) 740, ,683 (24,901) (1,014) 715, , , , , , , , , ,28
CNQC INTERNATIONAL HOLDINGS LIMITED 1240 2 3 4 11,053,456 7,302,293 5 (9,247,614) (6,227,767) 1,805,842 1,074,526 9,598 3,763 4,228 1,504 5 (165,624) (123,375) 5 (552,981) (389,389) 1,101,063 567,029 5,681
4. 27(2) 5. 6. 7. 8. 10,000,000 1,000,000,000 0.01 9. 2
Keen Ocean International Holding Limited 1. Keen Ocean International Holding Limited 2. Codan Trust Company (Cayman) Limited Cricket Square, Hutchins Drive, PO Box 2681, Grand Cayman, KY1-1111, Cayman
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GREAT WORLD COMPANY HOLDINGS LTD 8003 353 36 54 55 48 183 17M http://www.hkgem.com http://www.gwchl.com i ..................................................................... 1...............................................................
目 錄 頁 碼 定 義... I 董 事 會 函 件... 1 附 錄 I 財 務 信 息... I-1 附 錄 II 一 般 信 息... II-1 1
此 乃 要 件 請 即 處 理 閣 下 對 本 通 函 任 何 方 面 或 對 應 採 取 之 行 動 如 有 任 何 疑 問, 應 諮 詢 閣 下 之 註 冊 證 券 商 銀 行 經 理 律 師 專 業 會 計 師 或 其 他 專 業 顧 問 閣 下 如 已 售 出 或 轉 讓 名 下 全 部 康 哲 藥 業 控 股 有 限 公 司 股 份, 應 立 即 將 本 通 函 送 交 買 主 或 承 讓
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Reach New Holdings Limited () : 8471 2017 GEM GEM GEM GEM GEM GEM GEM GEM GEM 1 2017 2 3 4 10 11 14 15 24 25 34 35 38 39 40 41 42 43 44 79 80 PO Box 1350 Clifton House 75 Fort Street Grand Cayman KY1 1108
: 01250 Beijing Enterprises Clean Energy Group Limited 2015 2 3 5 10 11 12 13 14 15 24 28 01 2015 Clifton House 75 Fort Street, PO Box 1350 Grand Cayman, KY1-1108 Cayman Islands 18 67 6706-07 Appleby Trust
5 25,347 26,359 (9,642) (12,913) 15,705 13, ,951 3,954 (8,797) (43,127) 7 (53,776) (1,409) (6,837) (80,268) (84,388) 8 (12,581) (13,316) (31) 9
China Vanguard You Champion Holdings Limited ( ) GEMGEM GEM GEM GEM GEM GEM GEM GEM GEM 1 5 25,347 26,359 (9,642) (12,913) 15,705 13,446 6 13,951 3,954 (8,797) (43,127) 7 (53,776) (1,409) (6,837) (80,268)
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Modern Education Group Limited 1082 20121231 20121231 128,180,0002011167,060,00023.27% 4,050,000201110,590,00061.74% 2012123120110.025 20121231 2011 1 1231 2012 2011 4 128,176 167,056 5 21,555 1,050 7
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波 司 登 國 際 控 股 有 限 公 司 ( 於 開 曼 群 島 註 冊 成 立 之 有 限 責 任 公 司 ) 股 份 代 號 : 3998 2014/15 年 報 公 司 簡 介 目 錄 2 4 8 29 39 43 57 59 61 63 65 66 68 146 148 財 務 摘 要 ( 除 另 有 指 明 外, 所 有 金 額 以 人 民 幣 千 元 為 單 位 ) 3 31 2015
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KINGWELL GROUP LIMITED 1195 413 70 B1B68 18317M 48 ...................................................... 1................................................. 4.................................. 14...............................
目 錄 頁 次 釋 義......................................................... 1 董 事 會 函 件..................................................... 3 言.............
此乃要件 請即處理 閣下如對本通函任何方面或應採取的行動有任何疑問 應諮詢 閣下的股票經紀 其他持牌證 券商 銀行經理 律師 專業會計師或其他專業顧問 閣下如已售出或轉讓名下所有金嗓子控股集團有限公司的股份 應立即將本通函連同隨附的代 表委任表格送交買主或承讓人 或經手買賣的銀行 股票經紀或其他代理人 以便轉交買主或 承讓人 香 交易及結算所有限公司及香 聯合交易所有限公司對本通函的內容概不負責 對其準確性
EJE (HONG KONG) HOLDINGS LIMITED * 8101 GEM GEM GEM GEM GEM GEM GEM GEM GEM GEM GEM GEM (1) (2) * 1
EJE (HONG KONG) HOLDINGS LIMITED * 8101 GEM GEM GEM GEM GEM GEM GEM GEM GEM GEM GEM GEM (1) (2) * 1 5 132,409 135,524 (90,801) (98,470) 41,608 37,054 5 1,905 1,674 (10,460) (8,142) (45,962) (40,726) (4,919)
4 37,919 40,859 6 (1,752) (10,323) 36,167 30,536 35,919 30, (430) 36,167 30,
RIVERINE CHINA HOLDINGS LIMITED 1417 2017 12 31 2017 12 31 2016 12 31 2017 12 31 3(a) 363,303 309,268 4(a) (296,434) (248,625) 66,869 60,643 3(b) 7,611 10,283 (4,682) (4,188) (42,690) (31,267) 5 (1,496)
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SHIFANG HOLDING LIMITED 1831 1 19,125 20,443 1,266 1,500 4 5 27,013 22,907 47,404 44,850 6,472 5,583 50,511 51,527 6 101,021 7 10,314 9,714 5 4,390 5,382 220 522 117,729 109,492 290,657 182,220 338,061
4. 27(2) 5. 6. 7. 8. 0.01 10,000,000,000 0.01 9.
1. 2. Codan Trust Company (Cayman) Limited Cricket Square, Hutchins Drive, PO Box 2681, Grand Cayman, KY1-1111, Cayman Islands 3. (a) (b) 4. 27(2) 5. 6. 7. 8. 0.01 10,000,000,000 0.01 9. A 1 2 3 4-7 8-9
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China Resources Healthcare Group Limited Phoenix Healthcare Group Co. Ltd 1515 (1) (2) (3) (4) (5) (6) 9 55 56 57 58 132 2016 10 31 6 E-825 301 304 183 17M 48 2016 10 7 ... 1... 9... 56... 58... 133...
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Overseas Chinese Town (Asia) Holdings Limited 03366 ... 1.... 4... 16... 19.... 143... 174... 180 i (i) (ii) 1 2 4 56 03366 1 2048 S 144A 73,371,900 Credit Suisse (Hong Kong) Limited 2 Pacific Climax Pacific
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Sun International Group Limited 8029 10% 22-2622 15 19 28 26 www.hkgem.com i ............................................................. 1........................................................ 3....................................................
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2 3 9 12 14 16 17 18 2 * 183 17 1712-1716 Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY1-1111 Cayman Islands 1 A 30 B&C www.inspur.com.hk 596 * Royal Bank of Canada Trust Company (Cayman)
2 4 7 23 30 44 55 57 58 60 61 63 136 137 Huang James Chih-Cheng Huang James Chih-Cheng Appleby Trust (Cayman) Ltd. Clifton House 75 Fort Street P.O. Box 1350 Grand Cayman KY1-1108 Cayman Islands 88 1306
A 20%
TIANNENG POWER INTERNATIONAL LIMITED 00819 18 1518 48 18 15 18 5A 20% 15 18 1 5B 10% 571 0.1 2 TIANNENG POWER INTERNATIONAL LIMITED 00819 Cricket Square Hutchins Drive P.O. Box 2681 Grand Cayman KY1-1111
2 4 6 20 27 46 57 59 60 62 63 65 150 151 Huang James Chih-Cheng Huang James Chih-Cheng Appleby Trust (Cayman) Ltd. Clifton House 75 Fort Street P.O. Box 1350 Grand Cayman KY1-1108 Cayman Islands 88 1306
企 業 簡 介.......................................................................... 2 公 司 資 料...........................................................
Intime Retail (Group) Company Limited ( ) : 1833 2013 企 業 簡 介.......................................................................... 2 公 司 資 料..........................................................................
1 2 4 5 16 21 23 24 25 26 27 28 1 CA Cricket Square Hutchins Drive PO Box 2681 Grand Cayman KY1-1111 Cayman Islands 43 19 10 1009 Butterfield Fulcrum Group (Cayman) Limited Butterfield House 68 Fort Street
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SINO BIOPHARMACEUTICAL LIMITED : 1177 2017 1 1177 www.sinobiopharm.com FCCA,CPA 166 1 43 SMP Partners (Cayman) Limited Royal Bank House 3rd Floor, 24 Shedden Road P.O. Box 1586 Grand Cayman KY1-1110 Cayman
Shineroad International Holdings Limited 1587 6 17 18 19 20 35 291103 06 43 44 (www.hkexnews.hk) (www.shineroad.com) 48 18322 ...................................................................... 1...............................................................
I-1... II-1... III-1... EGM-1 i
CHINA RUIFENG RENEWABLE ENERGY HOLDINGS LIMITED 527 3 10 23 18 1801 EGM-1 EGM-2 48 183 22 ... 1... 3... I-1... II-1... III-1... EGM-1 i 1 86.55% (36) 6 % 2 CHINA RUIFENG RENEWABLE ENERGY HOLDINGS LIMITED
2 4 7 8 9 10 21 26 36 50 52 53 55 56 58
2 4 7 8 9 10 21 26 36 50 52 53 55 56 58 (ACCA, HKICPA) Clifton House 75 Fort Street P.O. Box 1350 Grand Cayman KY1-1108 Cayman Islands 465 103 www.chinauton.com 23 24 2404 2014 2 26 33 Appleby Trust (Cayman)
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COUNTRY GARDEN HOLDINGS COMPANY LIMITED 2007 2015 5 20 10 88 JW 3(1-4) 19 23 48 183 22 2015 4 14 ... 1 1.... 4 2.... 4 3.... 4 4.... 5 5.... 5 6.... 5 7.... 6 8.... 6 9.... 6... 7... 11... 19 i 2015 5
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RICI HEALTHCARE HOLDINGS LIMITED : 1526 2016 2 6 8 9 10 12 16 28 48 67 81 88 2017 2017 6 2 2016 6 23 2015 5 20 2014 7 11 2013 11 6 500 2 2014 7 11 (i)(ii) 2015 2 16 2015 6 29 3 2016 10 6 2016 10 6 2008
3 51,115,551 37,662,173 14,041,946 14,048,008 (12,294,931) (13,969,624) (4,241,232) (5,114,524) 38,820,620 23,692,549 9,800,714 8,933,484 3,648,828 52
Link Holdings Limited * 8237 GEM GEM GEM GEM GEM GEM GEM * 1 3 51,115,551 37,662,173 14,041,946 14,048,008 (12,294,931) (13,969,624) (4,241,232) (5,114,524) 38,820,620 23,692,549 9,800,714 8,933,484 3,648,828
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20171231 20171231138.792016 46.2% 23.6%0.5 8.112016 101.3% 6.5%20164.3% 33.192016101.2% 12.299.93 * 1 20171231 20171231 2017 2016 3 13,879,207 9,495,022 (10,598,430) (7,202,155) 3,280,777 2,292,867 4 106,810
(1) (2) (3)
年報 (1) (2) (3) 2 3 4 7 10 13 21 32 34 35 36 37 38 39 CPA CPA 28 29 PO Box 309 Ugland House Grand Cayman KY1-1104 Cayman Islands 168 200 21 2115 2116 Royal Bank of Canada Trust Company (Cayman) Limited
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CHINA METAL INTERNATIONAL HOLDINGS INC. 319 1 2 1 1316 183 46 48 .................................................... ii........................................................ 1....................................................
,801,000 1,473,691 20,764 12,778 (548,084) (452,982) (483,269) (395,241) (97,289) (66,548) (278,473) (209,777) (85,45
Tsui Wah Holdings Limited 1314 2015 3 31 3 31 2015 2014 1,801,000 1,473,691 22.2% # 1,266,388 1,105,011 14.6% 522,188 355,412 46.9% ## 12,424 13,268 (6.4%) 157,591 156,043 1.0% 157,407 156,031 0.9% 184
02 04 05 07 15 17 18 19 20 41 43 02 GBS, OBE, JP GBS, OBE, JP Conyers Dill & Pearman GBS, OBE, JP GBS, OBE, JP Butterfield Fund Services (Cayman) Limited Butterfield House 68 Fort Street P.O. Box 705,
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CHINA METAL INTERNATIONAL HOLDINGS INC. 319 1 2 1 11 13 183 46 48 .......................................................... ii.............................................................. 1.........................................................
................................................................ 1 1....................................................... 4 2.......................
WAI CHI HOLDINGS COMPANY LIMITED 1305 11 17 21 183 22 ................................................................ 1 1....................................................... 4 2..................................................
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VITAR INTERNATIONAL HOLDINGS LIMITED 195 3 6 1 2607 13 16 48 28 26 .................................................................... 1 2..............................................................
2 4 8 12 21 31 33 34 35 36 37 38 1-2014 - 2014 2 Royal Bank of Canada Trust Company (Cayman) Limited 4th Floor, Royal Bank House 24 Shedden Road George Town Grand Cayman KY1-1110 Cayman Islands 183 22
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2 3 6 13 17 25 31 44 48 49 51 52 54 116 1 Cricket Square, Hutchins Drive P.O. Box 2681 Grand Cayman KY1-1111 Cayman Islands B 9-A 1 36 SMP Partners (Cayman) Limited 3rd Floor, Royal Bank House 24 Shedden